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  • 1
    ISSN: 1434-193X
    Keywords: Flavonoids ; Catechin ; Isotopic labeling ; Carbon 13 ; Total synthesis ; French paradox ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -Racemic 4-[13C]catechin 14 has been synthesized in ten steps starting from potassium [13C]cyanide. The intermediate chalcone 9 was formed by acylation of the benzylated phloroglucinol 7 with the caffeic acid synthon 6, using the trifluoroacetic mixed anhydride. The flavonoid skeleton was then obtained by previously described reactions such as the reduction of chalcone 9 and dihydroxylation of flavene 11. Such [13C]-labelled polyphenols should prove to be useful tools for human biological investigations.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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