Publication Date:
2012-09-12
Description:
The conserved diagonal docking mode observed in structures of T-cell receptors (TCRs) bound to peptide–MHC ligands is believed to reflect coevolution of TCR and MHC genes. This coevolution is supported by the conservation of certain interactions between the germ-line–encoded complementarity-determining region (CDR)1 and CDR2 loops of TCR and MHC. However,...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General