Publication Date:
1978-08-11
Description:
Diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (Macaca fascicularis) than in sham-vasectomized control monkeys fed the same diet. The effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries, and intracranial cerebral arteries. Antibodies to sperm developed in all vasectomized monkeys, and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals. The immunological response to sperm antigens that often accompanies vasectomy may exacerbate atherosclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alexander, N J -- Clarkson, T B -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):538-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96532" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arteries/immunology/pathology
;
Arteriosclerosis/*etiology/immunology/pathology
;
Autoantibodies
;
Cholesterol/metabolism
;
Cholesterol Esters/metabolism
;
Diet, Atherogenic
;
Haplorhini
;
Macaca fascicularis
;
Male
;
Spermatozoa/immunology
;
Vasectomy/*adverse effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
