Publication Date:
1978-06-16
Description:
Antibodies to insulin receptors purified from rat liver membranes do not complete with [125I]insulin for binding to the insulin receptor but do precipitate solubilized receptors labeled with [125I]insulin. These antibodies have the insulin-like activities of enhancing glucose oxidation and inhibiting epinephrine-induced lipolysis in rat adipocytes. Thus, antibody binds to the receptor at a different site from that to which insulin binds, yet the interaction can initiate an effective biological response. These results indicate that the previously studied insulin-binding sites are the physiological macromolecular receptors for insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, S -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1283-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663609" target="_blank"〉PubMed〈/a〉
Keywords:
Acanthosis Nigricans/physiopathology
;
Adipose Tissue/metabolism
;
Animals
;
*Antibodies
;
Antigen-Antibody Reactions
;
Binding Sites
;
Binding, Competitive
;
Biological Transport
;
Epinephrine/pharmacology
;
Glucose/metabolism
;
Insulin/metabolism
;
Lipid Mobilization
;
Liver/immunology
;
Rats
;
Receptor, Insulin/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
