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Synthesis of 99m Tc-Radiolabeled Uridine as a Potential Tumor Imaging Agent (2018)

Springer

In: Radiochemistry

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Publication Date: 2018-03-09

Description: Uridine, a pyrimidine nucleoside essential for the synthesis of RNA and biomembranes, was radiolabeled with 99 m Tc to obtain a potential tumor imaging agent. The maximal radiochemical yield of about 96.5%, as determined by paper chromatography and instant thin-layer chromatography, was reached under the following optimum conditions: 1 mg of uridine, 20 μg of SnCl 2 ·2H 2 O as reducing agent, 20 mg of mannitol as a stabilizer, and pH 8. 99 m Tc-uridine is stable in vitro at room temperature for up to 6 h post labeling. The biodistrbution study in tumor-bearing mice shows high target-to-nontarget ratio. These results match with the high docking score of the complex on uridine phosphorylase enzyme. 99 m Tc-uridine shows promise as a tumor imaging agent.

Print ISSN: 1066-3622

Electronic ISSN: 1608-3288

Topics: Chemistry and Pharmacology

Published by Springer

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