Publication Date:
1978-09-01
Description:
Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and in vivo for depletion of phenylalanine in circulating blood. Sustained reduction of phenylalanine was achieved in less than 30 minutes. A 50% decrease of phenylalanine was obtained with a 2-hour application of enzyme reactors and was maintained for more than 2 days. Similar enzyme reactors have therapeutic potential for temporary management of phenylketonuric patients when their circulating phenylalanine becomes exceedingly high because of infection, fever, or pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambrus, C M -- Ambrus, J L -- Horvath, C -- Pedersen, H -- Sharma, S -- Kant, C -- Mirand, E -- Guthrie, R -- Paul, T -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):837-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567372" target="_blank"〉PubMed〈/a〉
Keywords:
Ammonia-Lyases/*therapeutic use
;
Animals
;
*Disease Models, Animal
;
Dogs
;
Enzymes, Immobilized/*therapeutic use
;
Extracorporeal Circulation
;
Humans
;
Phenylalanine/blood
;
Phenylalanine Ammonia-Lyase/*therapeutic use
;
Phenylketonurias/*therapy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
