Publication Date:
1978-03-24
Description:
A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horton, J E -- Wezeman, F H -- Kuettner, K E -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1342-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204011" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bone Resorption/*drug effects
;
Calcium/metabolism
;
Cartilage/*metabolism
;
Enzyme Inhibitors/pharmacology
;
Microbial Collagenase/*antagonists & inhibitors
;
Organ Culture Techniques
;
Osteoclasts/physiology/ultrastructure
;
Parathyroid Hormone/antagonists & inhibitors
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
