ISSN:
1434-193X
Keywords:
Metabolism
;
Biosynthesis
;
Glycosides
;
Carbohydrates
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---The ability of Streptomyces griseoviridis (strain Tü 3634) to glycosylate various carboxylic acids with L-rhamnose was investigated by feeding mainly heteroaromatic and aromatic carboxylic acids to growing cultures. The special application of the precursor-directed biosynthesis (PDB) gave rise to a wide variety of acyl α-L-rhamnopyranosides as novel metabolites. The experiments resulted in furanyl, pyrrolyl, thienyl, indolyl, and pyridyl derivatives (1-8), the analogues 9-24 were generated by feeding fluoro-, hydroxy- or aminobenzoic acids or cinnamic acids. All results are discussed with respect to the substrate specificity of the corresponding enzyme system.Supporting information for this article is available on the WWW under //http://www.wiley-vch.de/contents/jc_2046/2000/99567_s.pdf or from the author.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
