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Synthesis and α-Mannosidase Inhibitory Activity of Three Deoxy Derivatives of Mannostatin A (2000)

Ogawa, Seiichiro ; Morikawa, Takayuki

Weinheim : Wiley-Blackwell

Liebigs Annalen 2000 (2000), S. 1759-1765

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ISSN: 1434-193X

Keywords: Cyclitols ; Aminocyclitols ; Glycosidase inhibitors ; α-Mannosidase inhibitors ; Deoxygenation ; Chemistry ; General Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: ---Three deoxy derivatives 2-4 of the α-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean α-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives 2 and 3 retained some inhibitory activity, although reduced by a factor of about 100 relative to the parent, whereas it was completely lost with the 3-deoxy derivative 4. Structure and activity relationships are discussed in the light of these findings.

Additional Material: 1 Tab.

Type of Medium: Electronic Resource

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