ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Digitale Medien

Allo-immunization elicits CD8 + T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women (1999)

Wang, Yufei ; Tao, Louisa ; Mitchell, Elaine ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1004-1009

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners' mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 month of allo-immunization, there was significant upregulation in the concentrations of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12440

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2

Digitale Medien

Anti-cancer activity of targeted pro-apoptotic peptides (1999)

Ellerby, H. Michael ; Arap, Wadih ; Ellerby, Lisa M. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1032-1038

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have designed short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, and synthesized them by simple peptide chemistry. The 'homing' domain was designed to guide the peptide to targeted cells and allow ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12469

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3

Digitale Medien

Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils (1999)

Strausbaugh, Holly J. ; Green, Paul G. ; Lo, Ernest ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1057-1061

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Although the inflammatory response is essential for protecting tissues from injury and infection, unrestrained inflammation can cause chronic inflammatory diseases such as arthritis, colitis and asthma. Physiological mechanisms that downregulate inflammation are poorly understood. Potent ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12497

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4

Digitale Medien

The dangers of extended PCR in the clinic (1999)

Kajander, Olli A. ; Poulton, Joanna ; Spelbrink, Johannes N. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 965-966

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Rearranged mitochondrial (mt) DNA molecules are associated with an increasing spectrum of human diseases. To be pathologically important, such molecules must constitute a major fraction of total mtDNA, at least within affected tissues. Although this is easily demonstrated by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12379

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5

Digitale Medien

No increase in demyelinating diseases after hepatitis B vaccination (1999)

Weil, John G. ; Einhäupl, Karl M. ; Zipp, Frauke

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 964-965

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Anecdotal reports on recombinant hepatitis B vaccination have suggested that the vaccine may give rise to demyelination in the central nervous system. Some molecular features of both the virus and the vaccine could, theoretically, account for such adverse events. We report here ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12376

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6

Digitale Medien

India fast-tracks vaccine candidates (1999)

Jayaraman, K.S.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 970-970

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Indian government has launched an ambitious project to develop and manufacture new 'home-grown' vaccines against several communicable diseases within three years for just $4 million. The initiative marks the first time that the government has allocated funding specifically for vaccine R&D ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12389

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7

Digitale Medien

Indecision over human pesticide data (1999)

Dove, Alan

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 972-972

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A scientific advisory subcommittee convened by the US Environmental Protection Agency (EPA), Washington DC, to study the bioethics of testing pesticides on humans, has failed to reach a consensus, delaying EPA rulings on the issue. Even if the subcommittee eventually favors accepting data from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12393

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8

Digitale Medien

New rules for lazy professors (1999)

Simm, Michael

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 974-974

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A proposal to alter disciplinary regulations at universities so that professors can be fired has sparked a fierce debate in Germany. Abolishing the privileges that academic professors enjoy as civil servants is the only way to counter stagnation, insists Klaus Landfried, head of the assembly of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12401

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9

Digitale Medien

NBAC issues biosamples report (1999)

Ault, Alicia

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 974-974

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] While it agonizes over releasing its recommendations on the use of federal money for human embryonic stem cell research—a report that is certain to spark fury from one side or the other irrespective of the conclusion—the US National Bioethics Advisory Commission (NBAC) has published an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12403

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10

Digitale Medien

The Sceptical Witness (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 980-981

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ... This is an unusual book written by an 'elderly' man of forensic science. Be prepared to read an autobiography that carefully lays out a modest childhood in a pre-war Nottingham, UK, when many of the luxuries of modern day living such as electricity and en suite bathrooms were conspicuously ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12410

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11

Digitale Medien

Advocates push for new NIH Office (1999)

Novak, Kristine

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 972-972

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In keeping with the American penchant for public direction of the country's biomedical research strategy, Congressional representatives Henry Waxman (D-CA) and Connie Morella (R-MD) have introduced legislation requesting the creation of a permanent Office of Autoimmune Diseases within the Office ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12535

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12

Digitale Medien

Scientists react to government indecision (1999)

Brown, Phyllida

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 855-856

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Britain's "anti-science climate" is to blame for the government's delay in deciding whether to permit research into the therapeutic use of human embryonic stem cells. This is the conclusion of several leading UK researchers, including at least one for whom that atmosphere has now become ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11277

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13

Digitale Medien

China reorganizes research institutes... (1999)

Triendl, Robert

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 857-858

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Last month's official inauguration of the Shanghai Institutes for Biological Sciences (SIBS) testifies to the determination of the Chinese central government, and the Chinese scientific community, to reform public research organizations, increase overall research quality, and reinvigorate the ties ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11282

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14

Digitale Medien

New knowledge and opportunities, but no new money (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 859-859

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Australia's 30,000 postgraduate students will gain control of their research grants and be able to transfer the funds to universities of their choosing after the first year, according to proposals outlined in a government Green Paper on tertiary education released last month. The discussion ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11285

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15

Digitale Medien

California aims to direct global health (1999)

Spalding, B.J.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 860-860

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Universitites of California at San Francisco (UCSF) and Berkeley (UCB) have joined forces to establish the Institute for Global Health (IGH) to tackle international health policy, vaccine development and distribution and reproductive health. IGH, which will open for business next month in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11291

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16

Digitale Medien

The Wellcome Trust: Leadership and partnership in biomedical research (1999)

Dexter, Michael

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 861-864

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] box 1 The Wellcome Trust now has an asset base of more than £12 billion ($19 billion) and an annual expenditure of some £400 million, supporting more than 3,000 researchers, at 300 locations in 30 different countries. Put in context, this means that the Trust supports between 10 and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11294

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17

Digitale Medien

Linking innate and adaptive immunity (1999)

Palucka, Karolina ; Banchereau, Jacques

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 868-870

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Identification of precursor dendritic cells as the natural interferon-producing cells reveals their role in connecting two branches of the immune system (page ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11303

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18

Digitale Medien

Amyloid-β vaccine for Alzheimer d isease (1999)

Novak, Kristine

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 870-870

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Amyloid beta (Aβ) peptide, a 40-42 amino acid protein cleaved from the amyloid precursor protein (APP), is a main constituent of the amyloid plaques found in the brains of Alzheimer Disease (AD) patients. Much debate has revolved around the question of whether Aβ is part of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11307

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19

Digitale Medien

Febrile convulsions: a 'benign' condition? (1999)

Walker, Matthew C. ; Kullmann, Dimitri M.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 871-872

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A new rodent model of hyperthermia-induced seizures (page 888) raises questions about the role of GABAergic inhibition in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11308

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20

Digitale Medien

How the immune system puts the brain to sleep (1999)

Straub, Rainer H. ; Männel, Daniela N.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 877-879

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Tumor necrosis factor, an essential mediator of inflammation, inhibits degradation of the molecular switch RGS7 and may lead to the neurological changes that occur during inflammation (page ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11315

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21

Digitale Medien

Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits (1999)

Chen, Kang ; Baram, Tallie Z. ; Soltesz, Ivan

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 888-894

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Febrile (fever-induced) seizures affect 3–5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial. Combining a new rat model of complex febrile seizures and patch clamp ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11330

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22

Digitale Medien

The death and resurrection of tuberculosis (1999)

Bloom, Barry R. ; McKinney, John D.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 872-874

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DNA vaccines may be useful in overcoming persistent tuberculosis ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11309

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23

Digitale Medien

The great escape: Is immune evasion required for tumor progression? (1999)

Villunger, Andreas ; Strasser, Andreas

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 874-875

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A study on page 938 reports the identification of an ovarian and uterine tumor-associated ligand, RCAS1, which inhibits growth of activated T lymphocytes. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11311

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24

Digitale Medien

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon (1999)

Cella, Marina ; Jarrossay, David ; Facchetti, Fabio ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 919-923

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have identified two cell subsets in human blood based on the lack of lineage markers (lin–) and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and ILT3. One subset (lin –/ILT3+/ILT1+) is related to myeloid dendritic cells. The other subset ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11360

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25

Digitale Medien

Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves (1999)

Hoe, Nancy P. ; Nakashima, Kazumitsu ; Lukomski, Slawomir ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 924-929

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11369

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26

Digitale Medien

Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1 (1999)

Nakashima, Manabu ; Sonoda, Kenzo ; Watanabe, Takeshi

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 938-942

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Tumor-associated antigens that can be recognized by the immune system include the MAGE-family, p53, MUC-1, HER2/neu and p21ras (refs. 1, 2, 3, 4, 5, 6). Despite their expression of these distinct antigens, tumor elimination by the immune system is often inefficient. Postulated mechanisms ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11383

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27

Digitale Medien

Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury (1999)

Azbill, Robert D. ; Knapp, Pamela E. ; Springer, Joe E.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 943-946

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Traumatic spinal cord injury often results in complete loss of voluntary motor and sensory function below the site of injury. The long-term neurological deficits after spinal cord trauma may be due in part to widespread apoptosis of neurons and oligodendroglia in regions distant from and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11387

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28

Digitale Medien

A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency (1999)

Brini, Marisa ; Pinton, Paolo ; King, Michael P. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 951-954

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In recent years, genetic defects of the mitochondrial genome (mtDNA) were shown to be associated with a heterogeneous group of disorders, known as mitochondrial diseases, but the cellular events deriving from the molecular lesions and the mechanistic basis of the specificity of the syndromes are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/11396

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29

Digitale Medien

Does cyclosporin A cause cancer? (1999)

Landewé, Robert B.M. ; van den Borne, Ben E.E.M. ; Breedveld, Ferdinand C. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 714-714

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Hojo et al. described a tumor growth-promoting effect of the immunosuppressive drug cyclosporin A (CsA) in immunodeficient mice. The effect was attributed to the upregulation of the cytokine transforming growth factor beta by CsA. CsA is used not only in transplant medicine to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10417

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30

Digitale Medien

Clinical research, or classical clinical research? (1999)

Persson, Carl

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 714-715

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—In the May issue, Bell emphasized the enormous potential of molecular medicine. Iterating the view that classical, clinical investigations have had their day, the author were enthusiastic that the new molecular medicine will unravel "the nature of disease." However, knowledge ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10419

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31

Digitale Medien

Local people threaten chimp sanctuary (1999)

Novak, Kris

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 718-718

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The paper by Beatrice Hahn and colleagues (Nature 397, 436; 1999) announcing that AIDS came from chimps has caused problems for Gloria Grow, founder of Canada's first chimp sanctuary. Grow is now embroiled in a battle with locals of Carignan, Quebec, who believe they may become infected by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10424

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Lawsuit reveals academic conflict-of-interest (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 717-717

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Texan lawsuits against the manufacturer of the so-called 'phen-fen' diet drugs Redux and Pondimin, Wyeth Ayerst, have revealed yet another problem for the biomedical research community borne of conflict of interest issues. The Dallas Morning News has reported that Wyeth paid Excerpta ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10423

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Digitale Medien

US to make research marijuana more accessible (1999)

Cimons, Marlene

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 721-721

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In a major policy shift, the Clinton administration has decided to release its hold on "research grade" marijuana, making it available to scientists who seek to study its medical benefits. The decision, announced by the Department of Health and Human Services (HHS), will open the way to new ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10432

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Digitale Medien

Localized, direct plasmid gene delivery in vivo : prolonged therapy results in reproducible tissue regeneration (1999)

Smiley, Elizabeth ; Patil, Pravin ; Goldstein, Steven ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 753-759

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The inability to deliver growth factors locally in a transient but sustained manner is a substantial barrier to tissue regeneration. Systems capable of localized plasmid gene delivery for prolonged times may offer lower toxicity and should be well-suited for growth factor therapeutics. We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10473

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Digitale Medien

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis (1999)

Moore, Robert J. ; Owens, David M. ; Stamp, Gordon ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 828-831

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Given the associations between chronic inflammation and epithelial cancer we studied susceptibility to skin carcinogenesis in mice deficient for the pro-inflammatory cytokine TNF-α (refs. 5,6). TNF-α–/– mice were resistant to development of benign and malignant skin tumors, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10552

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Digitale Medien

ON THE MARKET (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 847-848

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] OLIGOS TO ORDER Beckman has a new oligo sequence server software product for its Oligo 1000M DNA synthesizer. BOSS, which stands for Beckman oligo sequence server, software is intended for core facilities that produce oligos for other labs. It downloads text sequence information into the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0799_847

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Digitale Medien

BMS offers some relief for Africa's AIDS crisis (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 599-599

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The pharmaceutical company Bristol Myers Squibb (BMS) has announced a $100 million, five-year initiative aimed at developing long-term strategies to deal with the escalating problem of HIV in southern Africa. It will fund clinical research, physician training and community education programs in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9433

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Digitale Medien

Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev (1999)

Reddy, T.R. ; Xu, W. ; Mau, J.K.L. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 849-849

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Med. 5, 635– 642 (1999). On page 636, Fig. 2a was labeled incorrectly. The corrected figure is shown below. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/10581

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Digitale Medien

Deal creates lead cloning company (1999)

Firn, David

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 595-595

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Roslin Institute, the UK government research center that cloned Dolly the sheep, has sold its spin-out company, Roslin Bio-Med, to Geron, the Californian biotech company that hit the headlines last year for its work in isolating human embryonic stem cells. The new company, called Geron ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9421

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40

Digitale Medien

Cartilage to bone—Angiogenesis leads the way (1999)

Harper, Jay ; Klagsbrun, Michael

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 617-618

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Vascular endothelial growth factor plays an important part in longitudinal bone growth by stimulating angiogenesis into the epiphyseal growth plate (pages ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9460

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Digitale Medien

COX-2 Inhibitors – Is there cause for concern? (1999)

Seibert, Karen ; Lefkowith, James ; Tripp, Catherine ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 621-622

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A new study calls for further investigation into the potential benefits and risks of COX-2 specific inhibitors (pages ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9465

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Digitale Medien

Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine (1999)

Cafaro, Aurelio ; Caputo, Antonella ; Fracasso, Claudio ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 643-650

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9488

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43

Digitale Medien

The intrinsic factor–vitamin B 12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein (1999)

Kozyraki, Renata ; Fyfe, John ; Kristiansen, Mette ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 656-661

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cubilin is the intestinal receptor for the endocytosis of intrinsic factor–vitamin B12. However, several lines of evidence, including a high expression in kidney and yolk sac, indicate it may have additional functions. We isolated apolipoprotein A-I (apoA-I), the main protein of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9504

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Digitale Medien

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients (1999)

Lee, Peter P. ; Yee, Cassian ; Savage, Peter A. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 677-685

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We identified circulating CD8+ T-cell populations specific for the tumor-associated antigens (TAAs) MART-1 (27-35) or tyrosinase (368-376) in six of eleven patients with metastatic melanoma using peptide/HLA-A*0201 tetramers. These TAA-specific populations were of two phenotypically distinct ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9525

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Digitale Medien

New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet (1999)

Ochiya, Takahiro ; Takahama, Yasushi ; Nagahara, Shunji ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 707-710

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Skeletal muscle is a likely site for the delivery and expression of exogenous genes, both to treat local diseases and to act as a 'bioreactor' for producing therapeutic proteins to treat systemic diseases. Plasmid DNA-based gene delivery vehicles, unlike viral ones, do not require foreign ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/9560

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46

Digitale Medien

Osteogenesis imperfecta calls for caution-second letter (1999)

Bishop, N.J.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 466-466

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Horwitz and colleagues are to be congratulated on the successful engraftment of mesenchymal cells from donor marrow. However, the clinical changes they reported require careful evaluation, particularly when considering the potentially hazardous nature of the procedure and the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8528

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47

Digitale Medien

Adeno-associated virus 2 co-receptors?-first reply (1999)

Qing, Keyun ; Hansen, Jonathan ; Srivastava, Arun

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 468-468

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Qing et al. reply—The conclusion by Qiu et al. that HEp-2 and A431 cells do not express FGFR is wrong. The Muggeridge et al . report they quote clearly shows that the FGFR number per cell is approximately 300. There are few details of how Qiu et al. generated the data presented in their ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8526

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48

Digitale Medien

The sun sets on the CVI (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 469-470

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Many delegates attending a mid-March closed meeting led by the World Bank in Bellagio, Italy expressed emotions from disgust to amazement at what seemed to be the destruction of, rather than the transformation of, the Children's Vaccine Initiative (CVI). The meeting sounded the termination of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8334

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Digitale Medien

Is research suffering at academic health centers? (1999)

Ault, Alicia

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 472-472

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Three new publications suggest that managed care's increased dominance is constricting the ability of America's 125 medical schools and teaching hospitals— collectively known as academic health centers (AHCs)—to carry out biomedical research. Although the publications provide no ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8340

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50

Digitale Medien

NIAID to begin clinical transplant tolerance trials (1999)

Novak, Kristine

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 470-471

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A substantial new federal grant to be issued by the National Institute of Allergy and Infectious Diseases (NIAID) looks certain to 'push the envelope' of academic transplantation research by focusing on clinical tolerance trials for organ transplants and autoimmune diseases. Apparently, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8336

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51

Digitale Medien

US lead in immunology research threatened (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 471-471

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Based on a subjective assessment by its members, the Committee on Science, Engineering and Public Policy (COSEPUP) panel on "International Benchmarking of US Immunology Research" has concluded that the US is the world leader in immunology research. Despite this, the panel voiced concern in a report ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8339

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52

Digitale Medien

Italian government rebuffs emerging biotechnology industry (1999)

Ballmaier, Martina

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 363-363

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Italian government has complained to the European Court of Justice claiming that the European Union (EU) directive on patenting biotechnological inventions needs revision because of its inadequate consideration for the right of life and health and for the preservation of nature. The action ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7339

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53

Digitale Medien

Finding funding for China's HIV research (1999)

Watanabe, Myrna E.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 364-365

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] As Nature Medicine went to press, pediatric immunologist Arthur Ammann was presenting a briefing to members of the US Congress on the status of the HIV/AIDS epidemic in China. Ammann, former president of the American Foundation for AIDS Research (AmFAR) and former director of research at the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7345

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54

Digitale Medien

Stem cell debate heats up as guidelines are prepared (1999)

Birmingham, Karen ; Dove, Alan

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 366-366

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The argument over whether US government funding can be used for human embryonic stem cell research has intensified, on paper at least, and looks likely to enter its most critical period in the next three months. Although the Department of Health and Human Services (HHS) gave the green light to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7350

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Digitale Medien

Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy (1999)

Finzi, Diana ; Blankson, Joel ; Siliciano, Janet D. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 512-517

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8394

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56

Digitale Medien

Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations (1999)

Montefiori, David C. ; Johnson, R. Paul ; Manson, Kelledy H. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 526-534

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8406

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57

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Global elimination of trachoma: How frequently should we administer mass chemotherapy? (1999)

Porco, Travis ; Dawson, Chandler ; Blower, Sally ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 572-576

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The World Health Organization has recommended repeat mass drug administration as part of their global initiative to eliminate blinding trachoma by the year 2020. The efficacy of repeat treatment will be tested empirically, but the results will not be available for many years, and recommendations ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8451

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58

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Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming (1999)

Lee, Edwin A.M. ; Hannan, Carolyn M. ; Flanagan, Katie L. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 565-571

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Variation in epitopes of infectious pathogens inhibits various effector functions of T lymphocytes through antagonism of the T-cell receptor. However, a more powerful strategy for immune evasion would be to prevent the induction of T-cell responses. We report here mutual 'interference' with the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8444

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59

Digitale Medien

...or not to treat? (1999)

van de Belt, Hilbrand ; Neut, Daniëlle ; van Horn, Jim R. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 358-359

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—An earlier article emphasized the need to carefully reconsider the use of antibiotics in medicine and to complete the body of scientific evidence before any specific prescribing or control policy is effected. In orthopedic surgery, the use of antibiotics is common in joint ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7330

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Digitale Medien

...while Canada faces the issue head-on (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 361-362

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Canada is rapidly becoming an international leader in xenotransplantation. The country's xenotransplantation research activity has intensified over the last 12 months and now the Canadian government is gearing up to run a public consultation exercise on animal- to-human transplants, in addition ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7471

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61

Digitale Medien

Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques (1999)

Baba, T.W. ; Liska, V. ; Khimani, A.H. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 590-590

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Med. 5, 194– 203 (1999). On page 200, Table 4 contained an error. The correct Table is shown below. We regret this error. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/8859

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62

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Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective (1999)

Young, Deborah ; Lawlor, Patricia A. ; Leone, Paola ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 448-453

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The mammalian brain has a high degree of plasticity, with dentate granule cell neurogenesis and glial proliferation stimulated by an enriched environment combining both complex inanimate and social stimulation. Moreover, rodents exposed to an enriched environment both before and after a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7449

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Enrichment of epithelial cells for molecular studies (1999)

Maitra, Anirban ; Wistuba, Ignacio I. ; Virmani, Arvind K. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 459-462

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Quelle: Nature Archives 1869 - 2009

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Notizen: [Auszug] Accurate molecular analysis of tumors and their precursor lesions requires the extraction of specific subpopulations of cells (normal, preneoplastic and tumor) from a composite background of multiple cell types. Attempts to obtain pure tumor cell samples have resulted in the genesis of several ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7458

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Chinese genetics and ethics (1999)

Wertz, Dorothty C.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 247-247

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor–As the principal investigator of the 37-nation survey of ethics and genetics discussed in your News section in October 1998 (Nature Medicine 4, 1096; 1998), I would like to correct some misperceptions in your report on the ethical views of Chinese geneticists. Your report ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6433

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Filing a complaint (1999)

Koren, Gideon

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 247-247

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor–In your January 1999 letter from Nancy Olivieri, I am mentioned as "an Apotex-paid research fellow." I wouldn't mind being a research fellow again, if only nature could give me back the 15 years that have elapsed. However, I suspect this is against nature. Needless to say, I ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6434

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Novo Nordisk invests in academic diabetes research (1999)

Brown, Phyllida

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 250-250

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Britain's National Health Service (NHS) is teaming up with a university and a pharmaceutical company to build a $16 million center for research and treatment in diabetes and other hormonal and metabolic diseases. The partners hope that by bringing clinicians, academics and patients under one ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6438

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Funds bolster Canadian research (1999)

Birmingham, Karen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 251-251

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] As Nature Medicine went to press, it was widely anticipated that the Canadian budget announced on February 16th would include provision for a Canadian Institutes of Health Research (CHIR; Nature Med. 4, 989; 1998). In a pre-budget speech, Finance Minister Paul Martin told the Canadian parliament ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6444

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Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector (1999)

Greelish, James P. ; Su, Leonard T. ; Lankford, Edward B. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 439-443

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Limb-girdle muscular dystrophies 2C–F represent a family of autosomal recessive diseases caused by defects in sarcoglycan genes. The cardiomyopathic hamster is a naturally occurring model for limb-girdle muscular dystrophy caused by a primary deficiency in δ-sarcoglycan. We show here ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7439

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Tau gene mutation in familial progressive subcortical gliosis (1999)

Spillantini, M.G. ; Crowther, R.A. ; Chen, S.G. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 454-457

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Familial forms of frontotemporal dementias are associated with mutations in the tau gene. A kindred affected by progressive subcortical gliosis (PSG), a rare form of presenile dementia, has genetic linkage to chromosome 17q21-22 (refs. 1,2, 3). This kindred (PSG-1) is included in the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/7454

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Gene therapy and the germline (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 245-245

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Germline gene therapy and somatic gene therapy are two quite different proposals, and the legitimate concerns and risks of the former should not be used to stall progress on the latter. The biomedical research community should act quickly and decisively to divorce the two before pushing ahead ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6429

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Heart Development (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 260-260

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The heart is a topic of fascination for poets and scientists alike. Although detailed anatomic analysis of the developing heart has been available for decades—perhaps because it is the first organ to form and function in the mammalian embryo—it is only relatively recently that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6466

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Wellcome Trust builds African research center (1999)

Cass, Stephen

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 253-253

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Liverpool School of Tropical Medicine and the Universities of Liverpool and Malawi have opened a malaria research facility in Blantyre, Malawi. The center was funded by a Wellcome Trust grant of £460,000 (US$770,000) and provides facilities for scientists studying malarial pathology, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6452

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In utero gene therapy: The case for (1999)

Schneider, Holm ; Coutelle, Charles

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 256-257

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] No patient has been cured so far by gene therapy, so why discuss a prenatal approach? First, for many conditions, postnatal gene therapy may not be delivered in time to avoid irreversible disease manifestation. In contrast, supplementation of a therapeutic gene in utero may prevent the original ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6458

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Born That Way (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 259-260

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] William Wright is not a scientist or even a science journalist and he freely admits that his knowledge of genetics and molecular biology comes largely from reading magazine articles and elementary textbooks. He is, however, intelligent, nosey and a bit of a gossip, and that is what makes Born ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6464

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New pieces to the prostate cancer puzzle (1999)

Visakorpi, Tapio

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 264-265

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Expression of different pp32 gene family members and cross-talk between the HER-2/neu and androgen receptor signaling pathways may be involved in prostate cancer development (pages ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6472

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Fas counter-attack–the best form of tumor defense? (1999)

O'Connell, Joe ; Bennett, Michael W. ; O'Sullivan, Gerald C. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 267-268

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] New in vivo evidence confirms that tumor-expressed Fas ligand impairs immune responses to cancer by inducing apoptosis of anti-tumor immune effector ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6477

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NOS: Modulator, not mediator of cardiac performance (1999)

Hare, Joshua M. ; Stamler, Jonathan S.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 273-274

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The 'endothelial' isoform of nitric oxide synthase modulates (but is not obligatory for) cardiac muscle function; signaling by NO in different cellular compartments coordinates diverse effects within the cardiac myocyte (pages ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6486

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Fas ligand (CD95 ligand) controls angiogenesis beneath the retina (1999)

Kaplan, Henry J. ; Leibole, Marc A. ; Tezel, Tongalp ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 292-297

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A principal cause of blindness is subretinal neovascularization associated with age-related macular degeneration. Excised neovascular membranes from patients with age-related macular degeneration demonstrated a pattern of Fas + new vessels in the center of the vascular complex, surrounded by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6509

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Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathy (1999)

Badorff, Cornel ; Lee, Gil-Hwan ; Lamphear, Barry J. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 320-326

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Enteroviruses such as Coxsackievirus B3 can cause dilated cardiomyopathy, but the mechanism of this pathology is unknown. Mutations in cytoskeletal proteins such as dystrophin cause hereditary dilated cardiomyopathy, but it is unclear if similar mechanisms underlie acquired forms of heart ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6543

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The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo (1999)

Guevara, Natalia V. ; Kim, Han-Seob ; Antonova, Ekaterina I. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 335-339

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The tumor suppressor protein p53 is an essential molecule in cell proliferation and programmed cell death (apoptosis), and has been postulated to play a principal part in the development of atherosclerosis. We have examined the effect of p53 inactivation on atherogenesis in apoE-knockout mice, an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6585

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CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue (1999)

Grivel, Jean-Charles ; Margolis, Leonid B.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 344-346

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A rapid decline in T-cell counts and the progression to AIDS is often associated with a switch from CCR5-tropic (R5) HIV-1 to CXCR4–tropic (X4) HIV-1 or R5/X4 HIV-1 variants. Experimental infection with R5 HIV-1 causes less T-cell depletion than infection with X4 or R5/X4 variants in T-cell ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6565

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The pathogenesis of familial hypertrophic cardiomyopathy: Early and evolving effects from an α-cardiac myosin heavy chain missense mutation (1999)

Georgakopoulos, Dimitrios ; Christe, Michael E. ; Giewat, Michael ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 327-330

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Familial hypertrophic cardiomyopathy (FHC) is a genetic disorder resulting from mutations in genes encoding sarcomeric proteins. This typically induces hyperdynamic ejection, impaired relaxation, delayed early filling, myocyte disarray and fibrosis, and increased chamber end-systolic stiffness. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6549

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Immunity to non-cerebral severe malaria is acquired after one or two infections (1999)

Gupta, Sunetra ; Snow, Robert W. ; Donnelly, Christl A. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 340-343

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In areas of stable transmission, clinical immunity to mild malaria is acquired slowly, so it is not usually effective until early adolescence. Life-threatening disease is, however, restricted to a much younger age group, indicating that resistance to the severe clinical consequences of infection ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6560

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Correction to “Gene expression profiles of laser-captured adjacent neuronal subtypes” (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 355-355

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Medicine 5, 120; 1999 In the New Technology article "Gene expression profiles of laser-captured adjacent neuronal subtypes," which appeared in the January issue (Nature Medicine 5, 120; 1999), a company name was misspelled. The correct spelling is Arcturus ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/6581

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The dangers of DNA vaccination (1999)

Górecki, D.C. ; Simons, J. Paul

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 126-126

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—DNA vaccination has entered clinical trials, and may ultimately be used on a large scale. It involves the injection of naked DNA that encodes antigens under the control of a eukaryotic promoter, and results in strong and sustained humoral and cell–mediated responses. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5473

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CRC forced to compromise over tobacco funding ban (1999)

Firn, David

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 129-129

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] After 15 months of wrangling, the Cancer Research Campaign (CRC) has reached agreement with British universities on a policy that it hopes will prevent tobacco companies from funding medical and scientific research in the UK. The policy, which comes into force on April 6th, rules out CRC funding ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5477

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Remembering MOG: Autoantibody mediated demyelination in multiple sclerosis? (1999)

Wekerle, Hartmut

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 153-154

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A comparative study of acute lesions in multiple sclerosis patients and in marmosets suggests that anti–MOG antibodies are responsible for the demyelination characteristic of this autoimmune disease ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5514

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Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo (1999)

Walczak, Henning ; Miller, Robert E. ; Ariail, Kiley ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 157-163

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To evaluate the utility of tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) as a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) TRAIL to promote and stabilize the formation of trimers. Both were biologically active, inducing ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5517

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Endotoxin opens the Toll gates to innate immunity (1999)

Ulevitch, Richard J.

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 144-145

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Mice that are resistant to lipopolysaccharide have mutations in a Toll–like receptor, implicating members of this family in bacterial endotoxin ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5504

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Human embryonic stem cells: The future is now (1999)

Keller, Gordon ; Snodgrass, H. Ralph

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 151-152

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The development of human embryonic stem cells as a research tool and therapeutic option offers a number of potential applications including the replacement of damaged ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5512

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Live attenuated AIDS vaccines: Hazards and hopes (1999)

Johnson, R. Paul

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 154-155

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Continuing studies in neonate and adult macaques vaccinated with a live attenuated (triple–deleted) SIV vaccine confirm that this virus can cause AIDS in some neonates and adults (pages ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5515

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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin ,a component of the presenilin protein complex (1999)

Nishimura, M. ; Yu, G. ; Levesque, G. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 164-169

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The presenilin proteins are components of high–molecular–weight protein complexes in the endoplasmic reticulum and Golgi apparatus that also contain β-catenin. We report here that presenilin mutations associated with familial Alzheimer disease (but not the non–pathogenic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/5526

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93

Digitale Medien

An association between viral genes and human oncogenic alterations: The adenovirus E1A induces the Ewing tumor fusion transcript EWS–FLI1 (1999)

Sanchez-Prieto, Ricardo ; Alava, Enrique de ; Palomino, Teresa ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1076-1079

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Malignant transformation of human cells requires the accumulation of multiple genetic alterations, such as the activation of oncogenes and loss of function of tumor suppressor genes or those related to genomic instability. Among the genetic alterations most frequently found in human tumors are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12516

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94

Digitale Medien

Correction to “Modulation of oncogenic potential by alternative gene use in human prostate cancer” (1999)

Kadkol, S.S. ; Brody, J.R. ; Pevsner, J. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1087-1087

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Med. 5, 275– 279 (1999). On page 278, the original Fig. 3, ommitted four gap symbols and two amino-acid changes. The correct figure is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12530

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95

Digitale Medien

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans (1999)

Jones, Christopher R. ; Campbell, Scott S. ; Zone, Stephanie E. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1062-1065

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Biological circadian clocks oscillate with an approximately 24-hour period, are ubiquitous, and presumably confer a selective advantage by anticipating the transitions between day and night. The circadian rhythms of sleep, melatonin secretion and body core temperature are thought to be generated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12502

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96

Digitale Medien

Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: Applications for universal detection and quantitation (1999)

Cao, Li ; Ty, Likia ; Arlie, Marine ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1081-1085

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Molecular methods are important in the diagnosis of viral infections and molecular measurements of viral load have been used successfully for evaluating the prognosis of viral infections and for monitoring the efficacy of antiviral therapies. So far, HIV viral load has been measured routinely ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12520

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97

Digitale Medien

Erratum to “Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis” (1999)

Moore, R.J. ; Owens, D.M. ; Stamp, G. ; [weitere]

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 1087-1087

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Med. 5, 828– 831 (1999). On page 829, the legend for Fig 1 was incorrect. The corrected figure and legend are shown here. We regret this ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12532

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98

Digitale Medien

Uganda gives lessons in stemming the AIDS epidemic (1999)

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 963-963

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Although many economically developed countries have managed to reduce the devastating effects of HIV/AIDS through the use of new antiviral drugs, in many less-developed parts of the world, the disease continues to wreak havoc. However, statistics from the World Bank reveal that Uganda, a country ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12375

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99

Digitale Medien

Grants will determine European malaria vaccine future (1999)

Birmingham, Karen ; Wunsch, Hannah

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 969-969

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] When Adrian Hill's team began Phase I clinical testing of its DNA malaria vaccine in Oxford last month, it became the first-ever academic group to study a malaria vaccine in clinical trials in the UK. "That tells you a lot about malaria vaccine research in Europe," says Hill, referring to the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12384

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100

Digitale Medien

German cutbacks hurt science (1999)

Simm, Michael

[s.l.] : Nature America Inc.

Nature medicine 5 (1999), S. 971-971

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In an effort to combat Germany's growing national deficit, the country's new Treasury Secretary, Hans Eichel, has announced a plan to slash next year's federal budget by DM30 billion (US$16.4 billion). This burden, Eichel demands, must be shouldered by all government departments equally, and for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/12534

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