Publication Date:
2002-05-04
Description:
There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-d-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sillaber, Inge -- Rammes, Gerhard -- Zimmermann, Stephan -- Mahal, Beatrice -- Zieglgansberger, Walter -- Wurst, Wolfgang -- Holsboer, Florian -- Spanagel, Rainer -- New York, N.Y. -- Science. 2002 May 3;296(5569):931-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany. sillaber@mpipsykl.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988580" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
*Alcohol Drinking
;
Alcoholism/*etiology/genetics
;
Animals
;
Brain/metabolism
;
Corticotropin-Releasing Hormone/physiology
;
Ethanol/blood
;
Female
;
Hippocampus/physiology
;
In Vitro Techniques
;
Male
;
Mice
;
Mice, Knockout
;
Models, Animal
;
Mutation
;
Receptors, AMPA/metabolism
;
Receptors, Corticotropin-Releasing Hormone/*genetics/*physiology
;
Receptors, Kainic Acid/metabolism
;
Receptors, N-Methyl-D-Aspartate/*metabolism
;
Signal Transduction
;
Stress, Physiological/physiopathology
;
Stress, Psychological/*physiopathology
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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