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  • 1
    Electronic Resource
    Electronic Resource
    Regulation of gene expression in vivo following transduction by two separate rAAV vectors (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 757-761 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Control of gene expression is important to gene therapy for purposes of both dosing and safety. In vivo regulation of gene expression was demonstrated following co-injection of two separate recombinant adeno-associated virus vectors, one encoding an inducible murine erythropoietin transgene and the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0898-757
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  • 2
    Electronic Resource
    Electronic Resource
    Epstein-Barr–based episomal chromosomes shuttle 100 kb of self-replicating circular human DNA in mouse cells (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 762-768 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We describe the microcell fusion transfer of 100–200 kb self-replicating circular human minichromosomes from human into mouse cells. This experimental approach is illustrated through the shuttling of the latent 170 kb double-stranded DNA genome from the human herpesvirus, Epstein-Barr virus, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0898-762
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  • 3
    Electronic Resource
    Electronic Resource
    IGF in the clinic (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 601-602 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In response to John Fowlkes' letter concerning my “one-sided analysis” of IGF-1 in the March issue, I would propose that in fact it is his analysis which is biased in favor of the drug. In my article, I presented the research of numerous scientists who had used IGF-1 in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0798-601b
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  • 4
    Electronic Resource
    Electronic Resource
    Chloroplast-transgenic plants: Panacea-No! Gene Containment-Yes! (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 602-602 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: It is unfortunate that Stewart and Prakash have missed the point of maternal inheritance of foreign genes in MOST crops, when .they are engineered via the chloroplast genome. Such false and irresponsible statements, solely based on speculation and cursory knowledge or understanding ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0798-602
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  • 5
    Electronic Resource
    Electronic Resource
    Business and Regulatory News (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 603-605 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Swiss reject gene ban On June 7, Swiss voters overwhwlmingly rejected a proposal for a moratorium on the cultivation of genetically modified crops and bans on research on transgenic animals and the patenting of genetically modified organisms. Althrough the turnout was low (∼40%), almost ...
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    URL: http://dx.doi.org/10.1038/nbt0798-603
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  • 6
    Electronic Resource
    Electronic Resource
    Research News (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 606-606 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Rolling circles stay put With the help of a novel enzyme and a clever DNA. microarray-based assay, researchers at Yale University School of Medicine (New Haven, CT) and Oncor (Gaithersburg, MD) have developed a system that can detect rare single base changes in a large pool of DNA. The approa uses ...
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    URL: http://dx.doi.org/10.1038/nbt0798-606b
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  • 7
    Electronic Resource
    Electronic Resource
    This Month in Nature Biotechnology (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 607-607 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Designer blood Engineered hemoglobin—artificial blood—is currently in the clinic, but hurdles remain to its wide application. One problem is'ironically due to its extreme purity. In ischemia, caused by the lack of oxygen, hypoxanthine and xanthine oxidase are produced. When the ...
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    URL: http://dx.doi.org/10.1038/nbt0798-607
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacogenomics at work (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 885-885 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On a related note, the approval of Herceptin by the US Food and Drug Administration's (FDA's) Oncologic Drugs Advisory Committee, and its likely approval by the FDA itself for commercialization later this fall, is a window on the opportunities that will be afforded by pharmacogenomic approaches to ...
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    URL: http://dx.doi.org/10.1038/nbt1098-885b
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular Genetics: Silver as a biocide: Will resistance become a problem? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 888-888 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human encounters with silver-containing products are surprisingly numerous worldwide1–3, primarily as a biocide or antimicrobial agent. In water usage, silver- and copper-based disinfectants are used in hospital and hotel distribution systems to control infectious agents (for example, ...
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    URL: http://dx.doi.org/10.1038/nbt1098-888
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  • 10
    Electronic Resource
    Electronic Resource
    Business and Regulatory News (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 891-892 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Agbiotech endows Dow Four deals announced at the start of September involving Dow Chemical Company (Midland, MI) suggest the company is taking serious steps into the world of agricultural biotechnology. Dow AgriSciences (Indianapolis, IN), the Dow subsidiary focusing on agriculture, announced it ...
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    URL: http://dx.doi.org/10.1038/nbt1098-891
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  • 11
    Electronic Resource
    Electronic Resource
    NeXstar seeks better valuation through disintegration (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 898-898 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On August 19, NeXstar Pharmaceuticals (Boulder, CO) announced the potential spin-off of its drug-discovery operations, and the resignation of NeXstar president and CEO, Patrick Mahaffy. A spin-off would disassemble the company into two publicly traded entities, effectively undoing the original 1995 ...
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    URL: http://dx.doi.org/10.1038/nbt1098-898a
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  • 12
    Electronic Resource
    Electronic Resource
    Japanese abandon domestic trials (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 898-899 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A growing number of Japanese pharmaceutical companies are carrying out clinical trials of new drugs in Europe rather than in Japan, where regulations are notoriously rigorous and testing more expensive, according to a report released in August by the Japan External Trade Organization (JETRO; ...
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    URL: http://dx.doi.org/10.1038/nbt1098-898b
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  • 13
    Electronic Resource
    Electronic Resource
    FDA urged to comply with 1997 Reform Act (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 901-902 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mindful of requirements stipulated by the PDA Modernization Act of 1997 (FDAMA), officials from the Center for Biologies Evaluation and Research (CBER) of the US Food and Drug Administration (PDA; Rockville, MD) recently began consulting with “stakeholders,” including industry ...
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    URL: http://dx.doi.org/10.1038/nbt1098-901
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  • 14
    Electronic Resource
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    Roslin falsely accused of biopiracy (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 904-904 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] UK researchers at the Roslin Institute (Roslin, UK) have been falsely accused of biopiracy, because protesters incorrectly interpreted the address given on a patent. More importantly, the description of the patent at the center of the furor turns out not to support the allegations. However, other ...
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    URL: http://dx.doi.org/10.1038/nbt1098-904
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  • 15
    Electronic Resource
    Electronic Resource
    When blind is better: Protein design by evolution (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 617-618 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The road to wisdom? Well, it's plain and simple to express: Err and err and err again but less and less and less. PietHem, quoted in Darwin's dangerous idea: Evolution and the meanings of life Simon 6- Schuster, New York, p. 200. According to Darwin's staunchest supporters, all ...
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    URL: http://dx.doi.org/10.1038/nbt0798-617
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  • 16
    Electronic Resource
    Electronic Resource
    A freeze-dryer and a fertile imagination (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 618-619 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Only the most robust sperm can complete the long and arduous journey to the egg. Just how tough these little packages of DNA are has now become apparent in experiments reported in this issue by Wakayama and Yanagimuchi1. These authors were able to freeze-dry mouse sperm, keep them at room ...
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    URL: http://dx.doi.org/10.1038/nbt0798-618
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  • 17
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    Maize faces new hurdle in EU (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 11-12 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In a move that dazzles with brinkmanship, the European Commission (EC; Brussels) has put yet another barrier in front of the progress of food-related biotechnology products to the market and turned up the heat on a trade war with the US. It is the turn of the Scientific Committee on Plants of the ...
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    URL: http://dx.doi.org/10.1038/nbt0198-11b
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  • 18
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    Electronic Resource
    Latent HIV needs second knockout punch (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 15-15 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Two recently published studies by AIDS research teams led by Anthony Fauci at the US National Institutes of Health (Bethesda, MD) and David Ho of the Aaron Diamond Research Center (New York, NY) show that powerful antivirals seem only to suppress HIV, and not to knock it out. To complete the job, ...
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    URL: http://dx.doi.org/10.1038/nbt0198-15
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  • 19
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    Combinatorial chemistry at the crossroads (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 2-3 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The combinatorial chemistry field has evolved tremendously over the past five years. It has moved from nascent science to a technology platform that is changing the drug discovery process. From 1995 to 1997 alone, more than 60 agreements were completed between pharmaceutical companies and ...
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    URL: http://dx.doi.org/10.1038/nbt0198-2
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  • 20
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    Label this science science-free (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 1-1 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A spate of reports has once again propelled agricultural biotechnology products into the spotlight. In one instance, science continues to go by the wayside in the assessment of genetically engineered food plants; in another, a bid for political power has pitted one committee of scientists against ...
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    URL: http://dx.doi.org/10.1038/nbt0198-1b
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  • 21
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    Structural genomics: Bioinformatics in the driver's seat (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 625-627 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “Structural genomics” is not simply the latest piece of investor jargon. It describes the high-throughput generation of new protein structures and their analysis in the context of emerging genome sequence data. The term was first used in the context of solving structures across whole ...
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    URL: http://dx.doi.org/10.1038/nbt0798-625
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  • 22
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    This month in Nature Biotechnology (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 10-10 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Monitoring bacterial mRNA expression As the number of bacterial genomes sequenced continues to rise, the ability to identify genes expressed in response to different environmental stimuli will facilitate the engineering of those bacteria producing important metabolites as well as the discovery of ...
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    URL: http://dx.doi.org/10.1038/nbt0198-10
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  • 23
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    Either DNA or protein, dummy (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 12-12 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] How should one test whether a food contains genetically engineered ingredients or not? At the beginning of November, the Standing Committee on Foodstuffs—a committee comprising representatives of national food regulatory bodies within the EU—rejected EC proposals that tests should be ...
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    URL: http://dx.doi.org/10.1038/nbt0198-12a
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  • 24
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    Toward a global filamentous fungus genome sequencing effort (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 5-5 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Last year, “The First Fungal Genome Workshop” was held at the Center for International Trade and Development of Oklahoma State University (OSU; Stillwater, OK). Supported by OSU and several companies representing both industrial biotechnology and the traditional pharmaceutical ...
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    URL: http://dx.doi.org/10.1038/nbt0198-5
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  • 25
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    Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 59-63 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Antisense experiments are often complicated by the lack of reliable methods for selecting effective antisense sequences. Chimeric oligodeoxynucleotide (ODN) libraries and ribonuclease H (RNase H) were used to identify regions on the 1253 nucleotide angiotensin type-1 receptor (AT1) mRNA that are ...
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    URL: http://dx.doi.org/10.1038/nbt0198-59
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  • 26
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    Making genomics functional (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 1-1 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Although biology in the postgenomic era is still grist for Hollywood's science fiction mill—witness such current films as GATTACA, for example—events like the recently completed sequencing of the genome of the human Lyme disease pathogen (Nature 390:580–586, 1997) remind us that ...
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    URL: http://dx.doi.org/10.1038/nbt0198-1a
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  • 27
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    Sugaring the pill by design (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 19-20 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recently, there has been a dramatic increase in our knowledge of the biosynthetic pathways by which microorganisms produce antibiotics and other bioactive secondary metabolites. This has triggered many research groups to undertake the genetic manipulation of these pathways, in attempts to produce ...
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    URL: http://dx.doi.org/10.1038/nbt0198-19
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  • 28
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    A panoramic view of bacterial transcription (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 23-23 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The availability of whole genome sequences has ushered in a new era in the biological sciences. For the first time in human history, all (or most) of the genes of an organism can be represented. Translating this into useful functional information represents one of the greatest challenges to the ...
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    URL: http://dx.doi.org/10.1038/nbt0198-23
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  • 29
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    Sleeping beauty awakes (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 20-21 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In a paper published in Cell at the end of last year, Ivies et al. report the reconstruction of the gene for a novel transposase using information from the fossilized remains of transposable elements lying in the genomes of teleost fishes1. Not on a par with the creation of dinosaurs from DNA in ...
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  • 30
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    Urine as a substitute for milk? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 21-22 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In the early days of biopharming, three body fluids—milk, blood, and urine—were proposed for transgenic protein production and, over the past 10 years, several different proteins have been produced in the milk (and blood) of transgenic animals. With milk-produced antithrombin III ...
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    URL: http://dx.doi.org/10.1038/nbt0198-21
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  • 31
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    DNA variation and the future of human genetics (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 33-39 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The use of DNA variants in the mapping of the human genome and in the positional cloning of monogenie disease genes is well established. Determining the genetic bases of the more common “multifactorial” diseases, however, presents a major challenge. The genetics of these diseases are ...
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    URL: http://dx.doi.org/10.1038/nbt0198-33
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  • 32
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    Microbial natural products: Alive and well in 1998 (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 3-4 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The selective action exerted on pathogenic bacteria and fungi by microbial secondary metabolites ushered in the antibiotic era, and for 50 years we have benefitted from this remarkable property of the wonder drugs. The successes of the antibiotics—usually defined as low molecular weight ...
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    URL: http://dx.doi.org/10.1038/nbt0198-3
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  • 33
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    Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 45-48 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have used high-density oligonucleotide probe arrays (chips) for bacterial transcript imaging. We designed a chip containing probes representing 106 Hemophilus influenzae genes and 100 Streptococcus pneumoniae genes. The apparent lack of polyadenylated transcripts excludes enrichment of mRNA by ...
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    URL: http://dx.doi.org/10.1038/nbt0198-45
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  • 34
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    Accurate sequencing by hybridization for DNA diagnostics and individual genomics (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 54-58 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Medical DNA diagnostics will increasingly rely on an accurate and inexpensive identification of mutations that affect the function of a gene. To validate diagnostic sequencing by hybridization (SBH), a number of p53 samples were analyzed with the complete set of 8192 noncomplementary 7-mer ...
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  • 35
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    Theoretical design of antisense RNA structures substantially improves annealing kinetics and efficacy in human cells (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 64-68 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The success of antisense therapeutics is not predictable despite their widespread use in biotechnology and molecular medicine. The relationship between RNA structure and biological effectiveness is largely not understood; however, antisense RNA-mediated effects in vivo seem to be related to ...
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    The bladder as a bioreactor: Urothelium production and secretion of growth hormone into urine (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 75-79 
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    Notes: [Auszug] Uroplakin genes are expressed in a bladder-specific and differentiation-dependent fashion. Using a 3.6-kb promoter of mouse uroplakin II gene, we have generated transgenic mice that express human growth hormone (hGH) in their bladder epithelium, resulting in its secretion into the urine at ...
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    Patent applications in automation and robotics (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 89-89 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Patent # Subject Assignee Author Date : Status* WO 9732892 Composite for combinatorial organic synthesis comprising material bound to support—has readable marker identifying the material, and similar markers to identify materials used in each synthesis step, particularly for ...
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    Methods for extracting and amplifying genomic DNA isolated from frozen serum (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 91-94 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A variety of biological materials have been used as sources of genomic DNA for PCR. Human genetic studies commonly use genomic DNA extracted from buffy coats1,2. Genomic DNA extracted from whole blood is also used in PCR by forensic laboratories3–5. However, buffy coats or whole blood for DNA ...
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    People (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 689-689 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Genome Pharmaceuticals (Munich, Germany) has announced the appointment of Metin Colpan to its supervisory board. Dr. Colpan is cofounder, CEO, and president of Qiagen NV. He will take the board seat vacated by Hans Lehrach, one of Genome Pharmaceuticals' scientific founders. Leonard R. Borrmann ...
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    New Products (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 688-688 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Centrifuges Swinging rotor A new centrifuge from Heraeus (Hanau, Germany) has a swing-out rotor but remains low cost. The Labofuge 300 is especially useful for the centrifugation of blood collection tubes with a gel barrier, often used for the testing of viral particles in the sample. The ...
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    Combinatorial chemistry (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 691-693 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A little over a year ago, Nature Biotechnology published the first-ever map of the combinatorial chemistry universe based on data gathered by the author of this column1. Since that time, both the biotechnology and pharmaceutical industries have continued to recognize combinatorial chemistry as a ...
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    Gene knockouts galore (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 519-520 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The human genome effort has several goals. One of them is the generation of the complete nucleotide sequence, which is slated for completion at the end of 2005. In the meantime, efforts are under way to construct cDNA libraries, sequence portions of them, and deposit the 3′- or 5′-end ...
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    NIH peer review: Time for some changes (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 395-395 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US universities guarantee academic freedom to scholars who have demonstrated their professional excellence by means of a tenure system that protects them from reigning intellectual and political pressures. But in the biomedical sciences, tenure has lost much of its meaning since the cost of ...
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    Taking stock of scientific fraud (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 395-395 
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    Notes: [Auszug] The potential for conflict of interest by academic researchers now extends into a realm of outright fraud that is very much the biotechnology industry's business—and should make biotechnology executives and industry officials active partners in setting standards to help curb such behavior. ...
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    Telomerase and cellular lifespan: Ending the debate? (1998)
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    Nature biotechnology 16 (1998), S. 396-397 
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    Notes: [Auszug] Gerontology received a strong stimulus in the early 1960s when it was established that mass cultures of fetal human fibroblasts would undergo no more than about 50 population doublings in cell culture1,2. Studies of three clones indicated to the author that this was characteristic of all the ...
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    Agriculture: Biotechnology and food security for the 21st century: A real-world perspective (1998)
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    Nature biotechnology 16 (1998), S. 399-400 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Despite long-standing concerns about balancing population and food supplies, and many population control measures, world population continues to grow at about 1.5% a year, and is projected to reach 8 billion by 2020, and 11 billion by 2050. Almost all of this growth will occur in the already ...
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    Letter 1: Chloroplast-transgenic plants are not a gene flow panacea (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 401-401 
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    Notes: [Auszug] The assertion has been made recently by Daniell et al.' that chloroplast (cp) transformation will be a practical solution to the problem of crop transgenes flowing to related weeds. This is an overstatement. They argued that transformed cp DNA, which they apparently assumed to be exclusively ...
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    Letter 2: Chloroplast-transgenic plants are not a gene flow panacea (1998)
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    Nature biotechnology 16 (1998), S. 401-401 
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    Notes: [Auszug] There is chloroplast gene flow through pollen in higher plants. Two articles in Nature Biotechnology1-2 make the blanket claim that there is a lack of gene flow through pollen. The original research was done with tobacco in which there is clear evidence of gene flow through tobacco pollen under ...
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    Genetic ID (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 401-402 
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    Notes: [Auszug] To the editor: I am writing to correct a number of inaccuracies in the article, “Firms sleuth out transgenic foods,” (Nature Biotechnology 15:1331, December 1997). A central theme in the article was that, although Genetic ID provides world-class GMO testing services, we subscribe to ...
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    Reply to 'Genetic ID' (1998)
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    Nature biotechnology 16 (1998), S. 402-402 
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    Notes: [Auszug] John Hodgson replies: Dr. Fagan argues a number of points in a lawyerly fashion. Lawyers often seek to unpick the fabric of an arguments by pulling peripheral threads from its hem. I will add a few restorative stitches. First, I have no doubt that the recorded correspondence between Genetic ID ...
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    Erratum (1998)
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    Nature biotechnology 16 (1998), S. 402-402 
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    Notes: [Auszug] Last month's Business and Regulatory News Brief “Birth control for alley cats“ incorrectly reported that researchers have successfully immunized female cats against pregnancy and that the vaccine causes eggs to be destroyed by the immune system prior to implantation. The Salmonella ...
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    Germline gene therapy contemplated (1998)
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    Nature biotechnology 16 (1998), S. 407-407 
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    Notes: [Auszug] A group of leading academic scientists met early this spring at the University of California, Los Angeles (UCLA) to consider what technical obstacles need to be overcome before trying germline gene therapy experiments in humans. The participants agree that researchers probably will not be ready for ...
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    Researchers wary of fear-based ban on lentivirus gene therapy (1998)
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    Nature biotechnology 16 (1998), S. 407-408 
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    Notes: [Auszug] Some researchers who are developing lentivirus-based gene therapies fear that, despite assurances from officials at the US Food and Drug Administration (FDA, Rockville, MD), policy decisions about clinical uses of lentivirus-based vectors may depend more on emotional responses from the public than ...
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    Human artificial chromosomes coming into focus (1998)
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    Nature biotechnology 16 (1998), S. 415-416 
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    Notes: [Auszug] An ideal vector for gene transfer would be capable of introducing a gene(s) of interest with high efficiency into a wide range of cell types, achieving sustained and regulated gene expression, and maintaining the therapeutic gene(s) stably through many cell divisions'. While such a ...
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    Laboratory strategies for the year 2000 problem (1998)
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    Nature biotechnology 16 (1998), S. 482-483 
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    Notes: [Auszug] Many information technology experts fear the onset of the year 2000 because much long-standing computer code uses inexact formulas to keep track of the year. In many programs, the computer knows only that it is the year 98, leaving the question of the century in doubt. The computer's underlying ...
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    Mining for biogold (1998)
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    Nature biotechnology 16 (1998), S. 485-485 
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    Notes: [Auszug] Biomining: Theory, Microbes, and Industrial Processes by Douglas E. Rawlings (ed.) Springer-Verlag, Berlin, 1997. This 14-chapter, multiauthored monograph is the current “gold standard” for this relatively new subject. A previous 1990 volume, edited by Ehrlich and Brierley (both ...
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    People (1998)
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    Nature biotechnology 16 (1998), S. 487-487 
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    Notes: [Auszug] Hyal Pharmaceutical (Mississauga, Ontario, Canada) has announced the resignation of Samuel S. Asculai as president and CEO and the appointment of Zenas B. Noon Jr. to the position of interim president and CEO. Dr. Asculai will continue as a member of Hyal's board of directors. David Beier, ...
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    A shot in the arm for DNA vaccines (1998)
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    Nature biotechnology 16 (1998), S. 309-309 
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    Notes: [Auszug] In biotechnology, one can never quite tell where the next commercial opportunity is going to come from, as the story of the Oxford-based drug delivery company, Powder Ject Pharmaceuticals, illustrates. Powderject is a small company that has leveraged itself into a strong intellectual property ...
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    The Biological Weapons Convention and the biopharmaceutical industry: The views of the United Kingdom (1998)
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    Nature biotechnology 16 (1998), S. 310-310 
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    Notes: [Auszug] Reflecting perhaps the political realities of its time, the Biological and Toxin Weapons Convention (BWC), which entered into force in April 1975, contains no measures—such as inspections or declarations—to ensure compliance. Since the mid 1980s, however, there have been sustained ...
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    In hot pursuit of extremophiles (1998)
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    Nature biotechnology 16 (1998), S. 312-312 
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    Notes: [Auszug] When US Interior Secretary Bruce Babbitt and Vice President Al Gore traveled to Yellowstone National Park to commemorate its 125th anniversary last August, they also presided over a little-noticed milestone in the brief history of the biotechnology industry. For the first time ever, a private US ...
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    The emerging role of the genomics revolution in agricultural biotechnology (1998)
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    Nature biotechnology 16 (1998), S. 311-311 
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    Notes: [Auszug] Although those involved in the therapeutics and agricultural businesses rarely acknowledge the similarities of their enterprises, the impact of genomics is forcing this realization. In our view, the agrichemical industry is on the verge of shifting from chemistry-based, whole organism screening ...
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    Remune response (1998)
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    Nature biotechnology 16 (1998), S. 314-314 
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    Notes: [Auszug] To the editor: I would like to draw your attention to a misprint that appeared in a recent article entitled “Latent HIV needs a knockout punch”1. The therapy currently being developed by The Immune Response Corporation, under the trade name Remune, is not a “version of the HIV ...
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    Furry flasks? (1998)
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    Nature biotechnology 16 (1998), S. 314-314 
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    Notes: [Auszug] To the editor: Krensky writes that the human skin xenograft model of Sultan et al.1 is a “step forward” over other heterochimeric mouse models because it, as opposed to others, has a physiologic human microenvironment, i.e., the skin. This distinction may apply to those models that are ...
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    Business and Regulatory News (1998)
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    Nature biotechnology 16 (1998), S. 315-317 
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    Notes: [Auszug] Lidak upset; board stays Lidak Pharmaceutical (La Jolla, CA), which is seeking approval of its topical treatment for oral herpes, Lidakol, experienced a series of upheavals last month. The company had accepted a $130 million loan deal in January from privately held HealthMed (Santa Monica, ...
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    Research News (1998)
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    Nature biotechnology 16 (1998), S. 318-318 
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    Notes: [Auszug] Self-assembling combinatorials Combining the principles of molecular self-assembly with those of affinity chromatography, researchers have selected and amplified a DNA-binding compound from a combinatorial library. In a report in Tetrahedron Letters (38:8639–8643, 1998), Benjamin Miller and ...
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    This month in Nature Biotechnology (1998)
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    Nature biotechnology 16 (1998), S. 319-319 
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    Notes: [Auszug] Detecting drug resistance in a tube The control of tuberculosis (TB) worldwide begins with detection. The difficulty of identifying drug-resistant strains of Mycobacterium tuberculosis compounds the problem. The development of molecular beacons—reporter molecules that fluoresce upon ...
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    EU and EPC prepare for patent fight (1998)
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    Nature biotechnology 16 (1998), S. 321-321 
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    Notes: [Auszug] The European Directive on the Patenting of Biotechnology Inventions (the directive) is widely expected to pass the European Parliament (Strasbourg, France) in early summer. That will mark the end of a 10-year gestation period for this legislation, which is intended to harmonize patenting practice ...
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    Pharming cloning ban could spread (1998)
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    Nature biotechnology 16 (1998), S. 321-322 
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    Notes: [Auszug] The Dutch government's ban on nuclear transfer experiments at Pharming (Leiden, The Netherlands) could have implications for animal cloning across the whole of Europe. On February 17 of this year, two nontransgenic female calves cloned by nuclear transfer were born on a farm Ellen Peerenboom is a ...
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    Irish cook whisks up opposition to Monsanto's sugar (1998)
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    Nature biotechnology 16 (1998), S. 323-323 
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    Notes: [Auszug] Dorina Alien, Ireland's most famous TV cook, has added her voice to the protests against plans to expand trials in the Irish Republic involving sugar beet genetically modified to be resistant to Monsanto's (St Louis, MO) herbicide, Roundup. Five new trials of the crop are planned, and the Irish ...
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    UCS says EPA Bts around the bush (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 324-324 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Officials at the US Environmental Protection Agency (EPA, Washington, DC) expect to receive by mid-March a major new EPA-commissioned report from the EPA advisory panel—drawn from academia and the US Department of Agriculture—on insecticide-resistance management strategies for crop ...
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    DeKalb family makes Monsanto pay market valuation (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 325-325 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The heirs to DeKalb Genetics (DeKalb, IL) decided to sell their controlling interest in the family business in early February. Although the company is facing eight litigation cases involving genetically altered crops, the family cited “estate planning needs” when announcing their ...
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    OGS tests mettle of merit-based investors in UK (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 326-326 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In mid-February, Oxford GlycoSciences (OGS; Abingdon, UK) announced that it planned to raise £30 million (US$49.5 million) through a public share offering on the London Stock Exchange (LSE). This made it the third UK company in 1998 to seek public finance, after Quadrant Healthcare ...
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    UCSF targets cancer IND (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 328-328 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Following several studies in tumor-grafted nude mouse models that have demonstrated tumor inhibition, regression, and cures, researchers at the University of California–San Francisco (UCSF) are plan­ning to move an immunoliposome agent that targets breast cancer cells into clinical trials ...
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    Japan plans economic growth through biotechnology (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 329-330 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Despite the continuing economic struggle in Japan, which has spurred the government to reduce the budgets of most of its ministries considerably, support for biotechnology is still on the increase. Furthermore, there are now several government efforts to ensure that the technology it supports is ...
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    Detecting drug-resistant tuberculosis: Beacons in the dark (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 331-331 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The control of tuberculosis remains one of the more elusive goals of medical science. With the disease reaching epidemic proportions in Africa, Asia, Eastern Europe, and South and Central America, few new treatments on the horizon, and new vaccine development still the subject of sessions at ...
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    PNA, antisense, and antimicrobials (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 332-332 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A key objective for those interested in the discovery of new antimicrobial agents is the determination of the genes essential for survival of pathogenic organisms. Novel micro-bial genes and their function have been the focus of intense research over the past two decades, and the publication and ...
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    Containing excitement over transplastomic plants (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 333-334 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Several traits engineered into agricultural crops require high-level expression of the newly introduced gene(s). Many transgenic plants never even reach the farmer because expression of the new trait is either not strong enough or insufficiently reliable. Plants with new genetic information ...
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    WAPping gastroenteritis with transgenic antibodies (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 334-335 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In this issue, Luis Enjuanes and colleagues1 present an interesting, innovative, and original application of transgenic technology to a common and economically significant problem of livestock producers, namely how to effectively provide immunity against enteric pathogens to neonate animals. ...
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    Transfected human dendritic cells as cancer vaccines (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 335-336 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since the declaration of President Nixon's war against cancer in the 1970s, great advances have been made in the design of therapies to specifically induce or exploit immune responses against tumor cells, complementing more traditional anticancer agents that target cellular metabo­lism. A recent ...
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    Mining the genetic riches of human populations (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 337-340 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In human genetic studies, one person's genetic resource is another's cultural heritage. New ethical approaches may be needed to resolve current conflicts. Isolated and inbred human populations are a valuable resource for biotechnology and pharmaceutical companies. It is certainly undeniable that ...
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    Therapeutic repair of mutated nucleic acid sequences (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 341-344 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The principle of therapeutic nucleic acid repair has been demonstrated in cell-free and cell culture experiments, in which compounds bind to and repair mutated sequences, thereby treating the primary defects of genetic disease. The mechanisms used to promote repair are diverse, encompassing ...
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    Containment of herbicide resistance through genetic engineering of the chloroplast genome (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 345-348 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Glyphosate is a potent herbicide. It works by competitive inhibition of the enzyme 5-enol-pyruvyl shikimate-3-phosphate synthase (EPSPS), which catalyzes an essential step in the aromatic amino acid biosynthetic pathway. We report the genetic engineering of herbicide resistance by stable ...
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    Engineering passive immunity in transgenic mice secreting virus-neutralizing antibodies in milk (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 349-354 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Protection against enteric infections can be provided by the oral administration of pathogen-neutralizing antibodies. To provide passive immunity, 18 lines of transgenic mice secreting a recombinant monoclonal antibody (Mab) neutralizing transmissible gastroenteritis coronavirus (TGEV) into the ...
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    Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 355-358 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptide nucleic acid (PNA) is a DNA mimic with attractive properties for developing improved gene-targeted antisense agents. To test this potential of PNA in bacteria, PNAs were designed to target the start codon regions of the Escherichia coli β-galactosidase and β-lactamase genes. ...
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    Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 359-363 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We developed a new approach to DNA sequence analysis that uses fluorogenic reporter molecules—molecular beacons—and demonstrated their ability to discriminate alleles in real-time PCR assays of genomic DNA. A set of overlapping molecular beacons was used to analyze an 81-bp region of ...
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    Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 364-369 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Dendritic cells (DC) generated from the peripheral blood mononuclear cells of healthy individuals or from cancer patients transfected with carcinoembryonic antigen (CEA) mRNA stimulate a potent CD8+ cytotoxic T lymphocyte (CTL) response in vitro. DCs are effectively sensitized with RNA in the ...
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    Genetic engineering of proteins with cell membrane permeability (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 370-375 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The discovery of methods for generating proteins with inherent cell membrane-translocating activity will expand our ability to study and manipulate various intracellular processes in living systems. We report a method to engineer proteins with cell-membrane permeability. After a 12–amino acid ...
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    Selection for a periplasmic factor improving phage display and functional periplasmic expression (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 376-380 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The efficiency of both phage display in Escherichia coli and periplasmic expression of recombinant proteins may be limited by the same periplasmic folding steps. To search for E. coli factors that improve the efficiency of both procedures, a library of E. coli proteins was coexpressed in a phagemid ...
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    Sequencing exons 5 to 8 of the p53 gene by MALDI-TOF mass spectrometry (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 381-384 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Matrix-assisted laser desorption ionization time of flight mass spectrometry was used to sequence exons 5 to 8 of the human p53 gene. A single tube procedure was established for target amplification and mass spectrometric (MS) sequencing. The MS sequencing scheme is designed for high throughput and ...
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    Building a fast–track patent portfolio in the UK and Europe (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 385-386 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Obtaining patent rights in Europe first may yield a handsome return on investment.For both start-up biotechnology companies and academic institutions, a fast track for patenting confers numerous advantages in the marketplace. For biotechnology companies, a granted patent, as opposed to an ...
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    Selected patent applications in carbohydrate sequencing (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 387-387 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Patent ♯ Subject Assignee Author Date Status* WO 963941 7 Performing chemical, biochemical, or biological reactions by trapping a particle in an optical trap and moving it through various reagents in regions of thin film; useful in the synthesis and sequencing of oligonucleotides, ...
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    Contract research organizations on the Web (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 388-388 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In the late 1990s, conventional wisdom holds that to become and stay successful, businesses need to have a presence on the Web. This is paticularly important for service companies, a category that includes contract research organizations (CROs). But exactly what kind of Web presence is needed, and ...
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    Microscopy (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 390-390 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Automated microscopes Nikon's (Badhoevedorp, The Netherlands) Eclipse microscopes are fully motorized and have a host of automatic functions. They can choose the ideal setting automatically for each magnification, automatically adjust the height of the stage, change the field diaphragm, and ...
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    People (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 392-392 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Jeremy Curnock Cook, director of International Biotechnology Trust pic, has been elected chairman of the board of Targeted Genetics (Seattle), a newly created position. Mr. Curnock Cook currently serves as director of Rothschild Asset Management Ltd. Idun Pharmaceuticals (La Jolla, CA) has ...
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    Proteomics (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 393-394 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An ambitious drug development platform attempts to link gene sequence to expressed phenotype under various physiological states.If there is one criticism that can be lodged against genomics as a tool for drug discovery, it is that DNA sequence information provides only a static snapshot of all the ...
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    Geron's vision: Less than 20/20 (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 211-211 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Working on the problems of aging seems to have dulled the vision of the scientific staff and associates of Geron, a biotechnology company attempting to develop diagnostics and therapeutics for cancer and age-related diseases based on the biology of telomeres and telomerase. Instead of the ...
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    Genomics and developmental biology (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 211-211 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nature Biotechnology's conference, “PharmacoGenesis: Postgenomic Drug Discovery through Developmental Biology,” to be held March 26-27 in Boston, MA, may be a harbinger of a future method of drug design that will join the tool sets of genomics for discovering and validating therapeutic ...
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    How will the Human Genome Project improve our quality of life? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 212-213 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] By itself, DNA sequence information can rarely provide definitive information about the function of particular genes. Studies of gene function include where and when a given gene is expressed and what the gene actually does. Function is complicated since it inevitably involves the interplay of many ...
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    Genetically engineered organic food? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 214-214 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Some 4000-odd letter writers have lambasted the US Department of Agriculture's (USDA; Washington, DC) proposed national standards for organic foods. The mantra of the organic farmers, granola eaters, and others who responded to the USDA's proposed standards amounts to a thunderous rejection of the ...
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    Helicobacter pylori : A surprisingly conserved bacterium (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 216-217 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It is one of the dogmas of the pharmaceutical industry that antiviral agents are developed to be virus specific, whereas antibacterials should be broad spectrum in nature. Very few bacteria justify themselves as standalone targets for pharmaceuticals. Such a designation requires that the organism ...
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