Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract Calorimetric and potentiometric studies have been made at 25°C of the formation of zinc and cadmium complexes of diglycine and of the copper complexes of glycylsarcosine, glycineamide, glycylproline, glycyl-l-alanine, α-alanylglycine, and glycyl-γ-aminobutyric acid. In addition, a potentiometric investigation has been made of the formation of copperl-alanyl-l-alanine complexes. The data have been used to calculate ΔG, ΔH, and ΔS values for all the equilibria involved and, in the case of copper, these data strongly support a common structure for all the mono complexes at lower pH in which the copper is bound to the terminal—NH2 and the oxygen of the peptide group. At higher pH, thermodynamic functions have been determined for the dissociation of the peptide hydrogen atom which is labilized by the copper atom.
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