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  • stability  (198)
  • Springer  (198)
  • International Union of Crystallography (IUCr)
  • 1990-1994  (198)
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  • Springer  (198)
  • International Union of Crystallography (IUCr)
  • Wiley-Blackwell  (13)
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Year
  • 1
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    Journal of mathematical biology 32 (1994), S. 395-426 
    ISSN: 1432-1416
    Keywords: Uniform persistence ; stability ; Lyapunov functional ; level-crossing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Dynamical characteristics of an integrodifferential system modelling two species competition with hereditary effects are investigated; in particular we derive sufficient conditions for the persistence of the species, existence of an attracting periodic solution and ‘level-crossings’ of solutions about the periodic solution.
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  • 2
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    Journal of mathematical biology 32 (1994), S. 515-520 
    ISSN: 1432-1416
    Keywords: Gametophytic incompatibility ; model ; equilibrium ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The deterministic dynamics of the classical single-locus multiple-allele model of gametophytic incompatibility is analyzed with the intention to prove the conjecture that the symmetric state (uniform distribution of genotypes) is the only polymorphic equilibrium and that this equilibrium is globally asymptotically stable in the interior of the frequency simplex. It is shown that the minimum allelic frequency increases strictly over the generations as long as a uniform allelic distribution is not realized. Hence, the minimum allelic frequency is a Ljapunov function for the invariant set of genotypic frequencies characterized by a uniform allelic distribution. Within this set, the uniform genotypic distribution is approached in an exponential fashion, which proves the assertion. An evolutionary optimization rule associated with the global convergence to the symmetric state is implied by the fact that at this state the overall amount of pollen elimination resulting from incompatible crosses is minimized.
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  • 3
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    Machine learning 8 (1992), S. 363-395 
    ISSN: 0885-6125
    Keywords: Connectionism ; reinforcement learning ; robot path finding ; stability ; reactive systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper presents a reinforcement connectionist system which finds and learns the suitable situation-action rules so as to generate feasible paths for a point robot in a 2D environment with circular obstacles. The basic reinforcement algorithm is extended with a strategy for discovering stable solution paths. Equipped with this strategy and a powerful codification scheme, the path-finder (i) learns quickly, (ii) deals with continuous-valued inputs and outputs, (iii) exhibits good noise-tolerance and generalization capabilities, (iv) copes with dynamic environments, and (v) solves an instance of the path finding problem with strong performance demands.
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  • 4
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    Machine learning 8 (1992), S. 363-395 
    ISSN: 0885-6125
    Keywords: Connectionism ; reinforcement learning ; robot path finding ; stability ; reactive systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper presents a reinforcement connectionist system which finds and learns the suitable situation-action rules so as to generate feasible paths for a point robot in a 2D environment with circular obstacles. The basic reinforcement algorithm is extended with a strategy for discovering stable solution paths. Equipped with this strategy and a powerful codification scheme, the path-finder (i) learns quickly, (ii) deals with continuous-valued inputs and outputs, (iii) exhibits good noise-tolerance and generalization capabilities, (iv) copes with dynamic environments, and (v) solves an instance of the path finding problem with strong performance demands.
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  • 5
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    Aquatic sciences 52 (1990), S. 330-344 
    ISSN: 1420-9055
    Keywords: Flood ; phytoplankton succession ; reversion ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of the August 1987 River Reuss flood event on the phytoplankton biocoenosis in Lake Uri (Urnersee, part of Lake Lucerne, Switzerland) was investigated firstly by comparing biological, chemical and physical data sampled before the event with equivalent data sampled after the event; and secondly by comparing the phytoplankton succession in 1987 with that occurring in the “floodfree” year 1989. As a consequence of the flood, the physical and chemical environment of the phytoplankton was found to have undergone a change which resulted in an alteration in the composition of the phytoplankton community. The phytoplankton community existing previous to the flood event, which had been dominated byTabellaria fenestrata sensu Husted 1930 (K-strategist), was replaced by a biocoenosis characterized mainly by various species of flagellates, which represent a typical spring successional stage (r-strategists). After the externally-imposed perturbation, the return to stable physical and chemical conditions was followed by the re-establishment of the successional stage which had existed before the flood (termed “reversion” by Reynolds, 1980).
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  • 6
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    Journal of intelligent manufacturing 4 (1993), S. 183-198 
    ISSN: 1572-8145
    Keywords: Assembly planning ; subassembly ; liaison graph ; geometric reasoning ; assembly cost ; stability ; partial-order graph
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The distribution of assembly workstations enables assembly operations to be done in parallel, while the multiple routing of parts in flexible assembly systems allows the opportunistic scheduling of assembly operations. This paper presents an assembly planning system, called the Assembly Coplanner, which automatically constructs an assembly partial order and generates a set of assembly instructions from a liaison graph representation of an assembly based on the extraction of preferred subassemblies. Assembly planning in Coplanner is carried out by the co-operation of multiple planning agents, such as the geometric reasoner, the physical reasoner, the resource manager and the plan coordinator, under the constraints of finding a cost-effective assembly plan in a flexible assembly system. The Coplanner identifies spatial parallelism in assembly as a means of constructing temporal parallelism among assembly operations. This is achieved in the following way: (1) the selection of a set of tentative subassemblies by decomposing a liaison graph into a set of subgraphs based on feasibility and difficulty of disassembly; (2) the evaluation of each of the tentative subassemblies in terms of assembly cost represented by subassembly selection indices; and (3) the construction of a hierarchical partial order graph (HPOG) as an assembly plan. A case study applying the Coplanner to a mechanical assembly is illustrated in this paper.
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  • 7
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    Acta biotheoretica 39 (1991), S. 1-14 
    ISSN: 1572-8358
    Keywords: Hematological diseases ; first order partial differential equations ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract To address the possibility that proliferative disorders may originate from interactions between multiple populations of proliferating and maturing cells, we formulate a model for this process as a set of coupled nonlinear first order partial differential equations. Using recent results for the asymptotic behaviour of the solutions to this model, we demonstrate that there exists a region of coupling coefficients, maturation rates, and proliferation rates that will guarantee the stable coexistence of coupled cellular populations. The analysis shows that increases in the coupling between populations may ultimately lead to a loss of stability. Furthermore, the analysis indicates that increases (decreases) in the maturation and/or proliferation rates above (below) critical levels will lead either to instability in the populations or the destruction of one population and the persistence of the other.
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  • 8
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    Mathematical programming 47 (1990), S. 117-141 
    ISSN: 1436-4646
    Keywords: Bifurcation ; singularity ; parametric programming ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract The structure of solutions to the nonlinear parametric programming problem with a one dimensional parameter is analyzed in terms of the bifurcation behavior of the curves of critical points and the persistence of minima along these curves. Changes in the structure of the solution occur at singularities of a nonlinear system of equations motivated by the Fritz John first-order necessary conditions. It has been shown that these singularities may be completely partitioned into seven distinct classes based upon the violation of one or more of the following: a complementarity condition, a constraint qualification, and the nonsingularity of the Hessian of the Lagrangian on a tangent space. To apply classical bifurcation techniques to these singularities, a further subdivision of each case is necessary. The structure of curves of critical points near singularities of lowest (zero) codimension within each case is analyzed, as well as the persistence of minima along curves emanating from these singularities. Bifurcation behavior is also investigated or discussed for many of the subcases giving rise to a codimension one singularity.
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  • 9
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    Mathematical programming 61 (1993), S. 197-214 
    ISSN: 1436-4646
    Keywords: Epi-convergence ; epi-distance ; stability ; convex optimization ; approximate solutions ; subgradients ; level sets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract We prove that theε-optimal solutions of convex optimization problems are Lipschitz continuous with respect to data perturbations when these are measured in terms of the epi-distance. A similar property is obtained for the distance between the level sets of extended real valued functions. We also show that these properties imply that theε-subgradient mapping is Lipschitz continuous.
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  • 10
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    Computing 51 (1993), S. 271-292 
    ISSN: 1436-5057
    Keywords: 65N15 ; 65N99 ; 35A40 ; Box method ; boundary value problem ; finite volume method ; variational formulation ; stability ; error bounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Box-Methoden (Finite-Volumen-Methoden) sind verbreitete Verfahren zur Lösung physikalischer Erhaltungsgleichungen, insbesondere in der Strömungsmechanik. In dieser Arbeit werden zwei Methoden für elliptische Differentialgleichungen untersucht, die Diagonal-Boxen und die Schwerpunkt-Boxen. Da die Box-Methoden im Sinne von Petrov-Galerkin-Verfahren interpretiert werden können, erhält man vergleichbar zur Finiten-Element-Methode eine variationsrechnerische Stabilitäts- und Fehleranalyse. Damit werdenO(h)- undO(h 2)-Fehlerabschätzungen hergeleitet. Lokale Eigenwertprobleme führen zu Stabilitätsaussagen. Allerdings ergibt sich eine Abhängigkeit von der Anzahl und Art gestörter Vierecke. Insbesondere die Diagonal-Boxen sind anfällig für lokale Störungen.
    Notes: Abstract Box schemes (finite volume methods) are widely used in fluiddynamics, especially for the solution of conservation laws. In this paper two box-schemes for elliptic equations are analysed with respect to quadrilateral meshes. Using a variational formulation, we gain stability theorems for two different box methods, namely the so-called diagonal boxes and the centre boxes. The analysis is based on an elementwise eigenvalue problem. Stability can only be guaranteed under additional assumptions on the geometry of the quadrilaterals. For the diagonal boxes unsuitable elements can lead to global instabilities. The centre boxes are more robust and differ not so much from the finite element approach. In the stable case, convergence results up to second order are proved with well-known techniques.
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  • 11
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    Journal of inorganic and organometallic polymers and materials 2 (1992), S. 79-85 
    ISSN: 1572-8870
    Keywords: Phthalocyanines ; polymers ; siloxanes ; conductivity ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The author's work on the incorporation of phthalocyanines into inorganic polymers is reviewed. The synthesis of poly(siloxane phthalocyanines) and the synthesis and characterization of fluoro(phthalocyanine) Group III compounds and their conducting derivatives are described.
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  • 12
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    Journal of solution chemistry 22 (1993), S. 1151-1158 
    ISSN: 1572-8927
    Keywords: Molecular complexes ; solvent effect ; stability ; solid CT complexes ; nicotine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Interaction of nicotine with tetracyanoethylene and iodine was investigated spectrophotometrically and found to form strong CT complexes (n−π and n-σ*, respectively). The donor site involved in CT interaction is the pyrrolidine nitrogen. The nicotine-I2 complex exists as the ionic structure (nicotine) I+-I 3 − . Formation constants of the CT complexes in various solvents were determined from 10 to 25°C and are discussed in terms of the nature of the electron acceptor and solvent polarity. Solid CT complexes were synthesized and were characterized by microchemical analysis and infrared spectra techniques.
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  • 13
    ISSN: 1572-8900
    Keywords: Chemiluminescence ; oxidation ; stability ; acrylonitrile-butadiene-styrene (ABS)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The influence of lubricants, UV stabilizers, antioxidants, and metal deactivators on the resistance of ABS to thermal oxidation was studied by means of the chemiluminescence technique. Neither of the additives seems to affect significantly the induction period of oxidation. At the same time, the influence of various additives on the oxidation rate constant is remarkably different: the introduction of lubricants and UV stabilizers increases its value, while antioxidants and metal deactivators have the opposite effect. For the particular systems studied durability is decreased in samples containing the lubricant and UV stabilizers and increased in samples stabilized with the antioxidant and metal deactivator.
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  • 14
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    Catalysis letters 28 (1994), S. 25-31 
    ISSN: 1572-879X
    Keywords: vanadia/alumina ; stability ; NO x selective reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Changes of the V2O5/Al3O3 catalyst aged for up to 10 years under real conditions of the selective catalytic reduction of NO x by ammonia (SCR) at the tail gases of the nitric acid plant were characterized by51V NMR spectroscopy, porosimetry, temperature programmed reduction (TPR) and catalytic activity measurements. The catalytic activity and the redox properties of the catalyst were found intact. Only small variations of the ratio of the octahedral and tetrahedral vanadia species were documented by51V NMR on aged catalyst.
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  • 15
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    Celestial mechanics and dynamical astronomy 53 (1992), S. 219-226 
    ISSN: 1572-9478
    Keywords: Artificial satellite ; dissipative forces ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The effects of small external dissipative and disturbing forces on the non-linear planar oscillation of a cable connected satellites system in the central gravitational field of earth have been studied. Typical non-linear oscillation's phenomena arizing from the aforesaid external forces are shown to take place. The presence of these forces enables the application of asymptotic methods of the theory of non-linear oscillations due to Bogoliubov and Mitropolsky to the equation characterizing the non-linear oscillation of the system.
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  • 16
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    Celestial mechanics and dynamical astronomy 56 (1993), S. 45-50 
    ISSN: 1572-9478
    Keywords: Restricted problem ; stability ; planets of double stars
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Numerical simulations are made within the framework of the plane restricted three-body problem, in order to find out if stable orbits for planets around one of the two components in double stars can exist. For any given set of initial parameters (the mass ratio of the two stars and the eccentricity of their orbit around each other), the phase-space of initial positions and velocities is systematically explored. In previous works, systematic exploration of the circular model as well as studies of more realistic (elliptic) cases such as Sun-Jupiter and the nearby α Centauri and Sirius systems, large stable planetary orbits were found to exist around both components of the binary, up to distances from each star of the order or more than half the binary's periastron separation. The first results presented here for the η Coronae Borealis system confirm the previous studies.
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  • 17
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    Celestial mechanics and dynamical astronomy 58 (1994), S. 203-213 
    ISSN: 1572-9478
    Keywords: libration points ; resonances ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The stability of the triangular libration points in the case when the first and the second order resonances appear was investigated. It was proved that the first order resonances do not cause instability. The second order resonances may lead to instability. Domains of the instability in the two-dimensional parameter space were determined.
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  • 18
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    Celestial mechanics and dynamical astronomy 59 (1994), S. 345-374 
    ISSN: 1572-9478
    Keywords: Lagrangian points ; stability ; oblate primary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The non-linear stability of the libration pointL 4 in the restricted problem has been studied when there are perturbations in the potentials between the bodies. It is seen that the pointL 4 is stable for all mass ratios in the range of linear stability except for three mass ratios depending upon the perturbing functions. The theory is applied to the following four cases: (i) There are no perturbations in the potentials (classical problem). (ii) Only the bigger primary is an oblate spheroid whose axis of symmetry is perpendicular to the plane of relative motion (circular) of the primaries. (iii) Both the primaries are oblate spheroids whose axes of symmetry are perpendicular to the plane of relative motion (circular) of the primaries. (iv) The primaries are spherical in shape and the bigger is a source of radiation.
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  • 19
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    Celestial mechanics and dynamical astronomy 53 (1992), S. 145-150 
    ISSN: 1572-9478
    Keywords: Monodromy matrix ; Gauss hypergeometric equation ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new class of linear ordinary differential equations with periodic coefficients is found which can be transformed to the Gauss hypergeometric equation, and therefore the monodromy matrices are computable explicitly. These equations appear as the variational equations around a straight-line solution in Hamiltonian systems of the form H = T(p) + V(q), where T(p) and V(q) are homogeneous functions of p and q, respectively.
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  • 20
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    Journal of intelligent and robotic systems 6 (1992), S. 51-63 
    ISSN: 1573-0409
    Keywords: Scheduling ; flexible manufacturing systems ; stability ; feedback
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A genetic manufacturing environment is considered. The emphasis is on small-lot, discrete, and asynchronous type of manufacturing systems rather than high volume and continuous type. Two classes of scheduling policies are proposed to render the machine stable. The policies are of feedback type. The decision is made in real-time and on-line.
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  • 21
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    K-Theory 4 (1991), S. 363-397 
    ISSN: 1573-0514
    Keywords: Nonabelian K 1 ; noncommutative homotopy ; general linear group ; superspecial linear groups ; descending central series ; stability ; relative normal subgroups ; nilpotent sandwich classifications ; quasi-finite algebras
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract A functorial filtration GL n =S−1L n $$ \supseteq$$ S0L n $$ \supseteq$$ ⋯ $$ \supseteq$$ S i L n $$ \supseteq$$ ⋯ $$ \supseteq$$ E n of the general linear group GL n, n ⩾ 3, is defined and it is shown for any algebra A, which is a direct limit of module finite algebras, that S−1 L n (A)/S0L n (A) is abelian, that S0L n (A) $$ \supseteq$$ S1L n (A) $$ \supseteq$$ ⋯ is a descending central series, and that S i L n (A) = E n(A) whenever i ⩾ the Bass-Serre dimension of A. In particular, the K-functors k 1 S i L n =S i L n /E n are nilpotent for all i ⩾ 0 over algebras of finite Bass-Serre dimension. Furthermore, without dimension assumptions, the canonical homomorphism S i L n (A)/S i+1 L n (A)→S i L n+ 1(A)/S i+1 L n + 1 (A) is injective whenever n ⩾ i + 3, so that one has stability results without stability conditions, and if A is commutative then S0L n (A) agrees with the special linear group SL n (A), so that the functor S0L n generalizes the functor SL n to noncommutative rings. Applying the above to subgroups H of GL n (A), which are normalized by E n(A), one obtains that each is contained in a sandwich GL′ n (A, ρ) $$ \supseteq$$ H $$ \supseteq$$ E n(A, ρ) for a unique two-sided ideal ρ of A and there is a descending S0L n (A)-central series GL′ n (A, ρ) $$ \supseteq$$ S0L n (A, ρ) $$ \supseteq$$ S1L n (A, ρ) $$ \supseteq$$ ⋯ $$ \supseteq$$ S i L n (A, ρ) $$ \supseteq$$ ⋯ $$ \supseteq$$ E n(A, ρ) such that S i L n (A, ρ)=E n(A, ρ) whenever i ⩾ Bass-Serre dimension of A.
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    K-Theory 7 (1993), S. 333-367 
    ISSN: 1573-0514
    Keywords: Locally flat embedding ; pointed Hermitian module ; splitting ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We prove an existence result for topologically locally flat embeddings of 2-spheres in simply connected 4-manifolds. This topological result is deduced from a splitting theorem for pointed Hermitian modules over a cyclic group ring. A stability result for such modules is also proved. This applies to the isotopy classification of locally flat embeddings.
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    Human ecology 20 (1992), S. 145-167 
    ISSN: 1572-9915
    Keywords: agriculture ; development ; diversity ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Ethnic Sciences
    Notes: Abstract This paper reconsiders two widely held hypotheses about the effects of the green revolution, that it led to biological simplification and instability. The hypothesis of biological simplification (genetic erosion) is tested with evidence from Andean agriculture, where farmers maintain a significant degree of crop diversity even as they adopt modern crop varieties. The hypothesis of increased instability is tested with evidence from Asia where wheat and rice yields show no general pattern of increased instability. Neither of these hypotheses is confirmed. The conventional wisdom about the green revolution should be reconsidered with emphasis on resilience and variation in modernizing farming systems.
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    Journal of statistical physics 65 (1991), S. 725-745 
    ISSN: 1572-9613
    Keywords: Aggregation ; injection ; power law distribution ; stability ; relaxation ; stable distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We study a generalized aggregation process in which charged particles diffuse and coalesce randomly on a lattice. For one-dimensional and mean-field models, we show that there exists a statistically-invariant steady state when randomly charged particles are continuously injected. The steady-state charge distribution obeys a power law with the exponent depending both on the type of the injection and on the spatial dimension. The response of the system to a perturbation (i.e., relaxation) is characterized by either a power law decay (t −β ,β⩽1) or a compressed exponential decay [exp(−t α ),α〉1].
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    Journal of statistical physics 66 (1992), S. 1557-1574 
    ISSN: 1572-9613
    Keywords: Boltzmann ; chemical kinetics ; stability ; chaos ; entropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We consider the most general chemical reaction of the typen 1 A 1+...+n N A N ⇌m 1 B 1+...+m M B M whereN,M⩾1,n 1,...,n N andm 1,...,m M are positive integers defining the stoichiometry, andA 1,...,A N andB 1,...,B M are the names of chemicals or ions. We assume that ∑ i=1 N ni=∑ j=1 M mj. The time evolution of the concentrations is given by the law of mass action and leads to a dynamical system (with discrete or continuous time) which is governed by a polynomial map of the interval [B, C], where B⩾0 and C⩽1. We define the physically meaningful range for the parameters of the map, and we show that, within such a range, the map has a unique fixed point, which is stable and a global attractor, with the exception of one particular case, where bifurcation is observed.
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    Journal of superconductivity 6 (1993), S. 55-57 
    ISSN: 1572-9605
    Keywords: Superconductivity ; Bi-2223 ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract A general acid-base equilibrium theory was proposed to explain the formation and stability of the Bi-2223 phase based on the Lewis acid-base theory, and principle of metallurgical physical chemistry. The acid-base nature of oxide was defined according to the electrostatic force between cation and oxygen anion. A series of experimental facts were systematically explained based on the theory: substitution of Bi for Ca in. the Pb-free 2223 phase, and the effect of substitution of the high-valent cation for Bi3+; oxygen-pressure atmosphere, and the heat-schocking technique on the formation and stability of the 2223 phase.
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    Multidimensional systems and signal processing 4 (1993), S. 91-101 
    ISSN: 1573-0824
    Keywords: Bilinear transformation ; polynomial ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The paper presents a unified approach to calculation, for a given, nominal,G-stable polynomial, a corresponding stability region in the space of perturbed coefficients
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    Journal of intelligent and robotic systems 3 (1990), S. 259-289 
    ISSN: 1573-0409
    Keywords: Nonlinear decoupling ; feedback linearization ; functional analysis ; elastic robots ; robustness ; stability ; pole assignment ; nonlinear systems ; robot control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A robustness analysis and synthesis for incomplete nonlinear decoupling for a class of nonlinear systems is discussed. Rigid and elastic-joint robot models belong to this class. For the elastic case, a transformation facilitates the robustness analysis under a weak assumption. Charts with H 1- and H ∞- norms of closed-loop disturbance transfer functions of the nonlinear-decoupled system are presented for a robust pole assignment.
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    Journal of intelligent and robotic systems 6 (1992), S. 219-240 
    ISSN: 1573-0409
    Keywords: Force control ; slip-stick friction ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper explores two practical issues related to the force control of manipulators. The first issue examined is how system stability is effected by commonly occurring manipulator nonlinearities, such as sampled-data, control signal saturation and slip-stick friction. It is shown that discretely implemented force control algorithms can drive the feedback force controlled manipulator into a limit cycle, even for a very small sampling period that by far satisfies Shannon's sampling theorem. The bounds of stability are enhanced by the presence of control signal saturation and slip stick friction. The second issue investigated is the inclusion of a high gain inner position loop as a means to minimize the unpredictability in the steady state error due to slip-stick friction. In order to support the theoretical conclusions, experiments were performed with the PUMP 560 industrial robot testbed facility developed at Colorado State University.
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    Colloid & polymer science 271 (1993), S. 793-798 
    ISSN: 1435-1536
    Keywords: Cholesterol colloids ; surfactants ; surface charge ; zeta potential ; stability ; shape ; size ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Cholesterol colloids stabilised by Tween 20 (Colloid I), SDS-Et4 NBr (Colloid II), and CTAB-Nac (Colloid III) were prepared. Moving boundary electrophoresis established Colloid III to be positively charged with a zeta potential of 12.2 mV. Addition of 5 mmol dm−3 Na2SO4 and 0.1 mmol dm−3 bilirubin dye (Na-salt) decreased the zeta potential to 9.7 mV and 9.5 mV, respectively, by screening the surface charge of the colloidal particles. Higher concentrations of Na2SO4 and bilirubin (Na-salt) made making electrophoretic measurements difficult, and such a situation was also faced in the case of Colloid II even without external addition of an electrolyte. Addition of several electrolytes revealed that Colloids II and II were coagulated by the neutralisation of their positive charge, but Colloid I was destabilised by salting-out effect. Measured intrinsic viscosity values and electron microscopic measurements supported overall spherical shape of the colloid particles. Colloid II exibited structural viscosity; higher concentration of NaSO4 decreased the viscosities of Colloid II and II by electroviscous effect which helped indirect determination of the electrokinetic potential (23.7 mV) of Colloid II.
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    ISSN: 1435-1536
    Keywords: Microgel ; poly(N-isopropyl-acrylamide) ; surface methylation ; stability ; aggregation
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    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The stability of thermoreversible microgel particles of poly(N-isopropylacrylamide) having carboxylate surface charge groups has been studied in the presence of electrolyte and non-adsorbing polymer. Methylation of the surface charge groups leads to a decrease in the electrophoretic mobility of the particles and also the interparticle electrostatic repulsive potential, resulting in the material becoming more susceptible to flocculation. The Hamaker constant of the microgel particles increases with the decrease in the hydrodynamic size of the particles following heating. This brings about an increase in the van der Waals attractive energy which results in the particles aggregating in the presence of sufficient electrolyte. Under conditions of flow through membranes, where shearing forces are operative, the flocculation observed following the heating of the dispersions results in the blockage of pores.
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    Colloid & polymer science 272 (1994), S. 1166-1173 
    ISSN: 1435-1536
    Keywords: Gel-emulsions ; ESR spin-probe method ; order parameter ; isotropic hyperfine splitting constant ; correlation time ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract W/O gel-emulsions (high-internal-phase-volume-ratio emulsions) form in water (or brine) /tetraethyleneglycol dodecyl ether/heptane system above the HLB (hydrophile-lipophile balance) temperature of the system. A salt, which largely decreases cloud temperature in a water-nonionic surfactant system, makes the surfactant film rigid and the gel-emulsions hence become very stable. The effect of aded salt on the apparent order parameter “S”, and the isotropic hyperfine splitting constant “a N” in gel-emulsions was determined by the ESR spin probe method using 5-doxyl stearic acid as the spin probe. The apparent order parameter “S”, and the isotropic hyperfine splitting constant “a N” increase with increasing salinity in Na2SO4, CaCl2, and NaCl systems. It is considered that the surfactant molecules are tightly packed in these systems and this tendency is highly related to the stability of gel-emulsions. The salt dehydrates the hydrophilic moiety of surfactant and hence the lateral interactions of surfactant molecular layer at the water-oil interface increases. The observed difference in the apparent order parameter between the ordinary emulsions and the gel-emulsions suggests that most of the surfactant molecules are adsorbed at the oil-water interface (the surface of the water droplet) in gel-emulsions.
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    Mathematical programming 54 (1992), S. 57-67 
    ISSN: 1436-4646
    Keywords: Matchings ; stability ; extreme points ; polytope
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    Topics: Computer Science , Mathematics
    Notes: Abstract The purpose of this paper is to extend a modified version of a recent result of Vande Vate (1989) which characterizes stable matchings as the extreme points of a certain polytope. Our proofs are simpler and more transparent than those of Vande Vate.
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    Computing 44 (1990), S. 187-196 
    ISSN: 1436-5057
    Keywords: 65M10 ; Spectral method ; stability ; stability threshold
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    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Zur numerischen Lösung einer nichtlinearen Differentialgleichung dritter Ordnung, herrührend aus einem Strömungsproblem bei Gasteilchen, wird ein zeitdiskreter Pseudo-spektral-Algorithmus vorgeschlagen. Stabilität und Konvergenz des neuen Differenzenverfahrens werden analysiert. Numerische Vergleiche mit bestehenden Differenzenschemata sprechen klar zugunsten des neuen Verfahrens.
    Notes: Abstract A time-discrete pseudospectral algorithm is suggested for the numerical solution of a nonlinear third order equation arising in fluidization. The nonlinear stability and convergence of the new scheme are analyzed. Numerical comparisons with available finite-difference methods are also reported which clearly indicate the superiority of the new scheme.
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    European journal of nutrition 29 (1990), S. 219-228 
    ISSN: 1436-6215
    Keywords: Vitamin K ; Menadion ; Menadiol ; Bioverfügbarkeit ; Stabilität ; Geflügel ; vitamin K ; menadione ; menadiol ; bioavailability ; stability ; poultry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary A bioassay of vitamin K is described, based on the prothrombin clotting time of 3-week-old, vitamin-K-depleted, and cumatetralyl-sensitized male broiler chicks, using a homologous thrombokinase preparation. With this test it could be shown that the diacetate and dibutyrate esters of menadiol are vitamin-K-active. The bioactivity of menadione from these menadiolesters amounted to about 70 % of the standard menadione from a coated menadione sodium bisulfite (Dohyfral). Menadiol seems to be temperature-resistant under such conditions, whereby two uncoated MSB preparations lost about 60 % of their activity.
    Notes: Zusammenfassung In einem biologischen Testverfahren an Cumatetralyl sensibilisierten Küken konnte in 3 Versuchen anhand des Parameters Thromboplastinzeit mit homologer Thrombokinase gezeigt werden, da\ Menadioldiacetat und Menadioldibutyrat Vitamin-K-wirksam sind. Die biologische Wirksamkeit von Menadion aus diesen Menadiolestern betrug ca. 70 % der Menadionaktivität aus gecoatetem Menadionbisulfit (Dohyfral®). Im Gegensatz zu 2 ungeschützten MSB-Präparationen, welche bei Wärmebelastung ca. 60 % ihrer ursprünglichen Wirkung verloren, waren die Menadiolester temperaturstabil.
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    Journal of nonlinear science 1 (1991), S. 289-311 
    ISSN: 1432-1467
    Keywords: cytogel ; mechanochemical ; two-dimensional patterns ; cellular differentiation ; pattern formation ; stability
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    Topics: Mathematics , Physics
    Notes: Summary Contractile actomyosin systems play a central role in the generation of intracellular patterns. Models for pattern formation have benefited greatly from the application of mechanochemical theory. However, investigations of the patterns have been primarily qualitative in nature; the two-dimensional nature of the evolving patterns has not yet been addressed mathematically, nor has the evolution of stable heterogeneous steady-state solutions. We consider these issues, supporting our analytical predictions with numerical simulations in one and two spatial dimensions. We show how, for certain gels, the two and three-dimensional tensor equation which describes a balance of forces can be reduced to a reaction-diffusion equation.
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    Journal of nonlinear science 3 (1993), S. 477-539 
    ISSN: 1432-1467
    Keywords: nearly integrable systems ; spectral transform ; attractors ; traveling waves ; stability ; numerical methods
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    Topics: Mathematics , Physics
    Notes: Summary In this paper we rigorously show the existence and smoothness inε of traveling wave solutions to a periodic Korteweg-deVries equation with a Kuramoto-Sivashinsky-type perturbation for sufficiently small values of the perturbation parameterε. The shape and the spectral transforms of these traveling waves are calculated perturbatively to first order. A linear stability theory using squared eigenfunction bases related to the spectral theory of the KdV equation is proposed and carried out numerically. Finally, the inverse spectral transform is used to study the transient and asymptotic stages of the dynamics of the solutions.
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    Journal of nonlinear science 3 (1993), S. 307-327 
    ISSN: 1432-1467
    Keywords: bifurcation ; saddle node ; Hopf ; stability ; robustness ; optimization ; numerical methods ; transcritical ; pitchfork ; extended systems
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    Topics: Mathematics , Physics
    Notes: Summary Engineering and physical systems are often modeled as nonlinear differential equations with a vector λ of parameters and operated at a stable equilibrium. However, as the parameters λ vary from some nominal value λ0, the stability of the equilibrium can be lost in a saddle-node or Hopf bifurcation. The spatial relation in parameter space of λ0 to the critical set of parameters at which the stable equilibrium bifurcates determines the robustness of the system stability to parameter variations and is important in applications. We propose computing a parameter vector λ* at which the stable equilibrium bifurcates which is locally closest in parameter space to the nominal parameters λ0. Iterative and direct methods for computing these locally closest bifurcations are described. The methods are extensions of standard, one-parameter methods of computing bifurcations and are based on formulas for the normal vector to hypersurfaces of the bifurcation set. Conditions on the hypersurface curvature are given to ensure the local convergence of the iterative method and the regularity of solutions of the direct method. Formulas are derived for the curvature of the saddle node bifurcation set. The methods are extended to transcritical and pitchfork bifurcations and parametrized maps, and the sensitivity to λ0 of the distance to a closest bifurcation is derived. The application of the methods is illustrated by computing the proximity to the closest voltage collapse instability of a simple electric power system.
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    Journal of nonlinear science 4 (1994), S. 449-470 
    ISSN: 1432-1467
    Keywords: solitary waves ; stability ; nonlinear dispersive wave equations ; model equations for long waves ; Korteweg-de Vries-type equations ; regularized long-wave equations ; nonlinear Schrödinger equations ; 35B35 ; 35B40 ; 35Q35 ; 35Q51 ; 35Q53 ; 35Q55 ; 35S10 ; 76B15 ; 76B25 ; 76E30 ; 86A05
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    Topics: Mathematics , Physics
    Notes: Summary After a review of the existing state of affairs, an improvement is made in the stability theory for solitary-wave solutions of evolution equations of Korteweg-de Vries-type modelling the propagation of small-amplitude long waves. It is shown that the bulk of the solution emerging from initial data that is a small perturbation of an exact solitary wave travels at a speed close to that of the unperturbed solitary wave. This not unexpected result lends credibility to the presumption that the solution emanating from a perturbed solitary wave consists mainly of a nearby solitary wave. The result makes use of the existing stability theory together with certain small refinements, coupled with a new expression for the speed of propagation of the disturbance. The idea behind our result is also shown to be effective in the context of one-dimensional regularized long-wave equations and multidimensional nonlinear Schrödinger equations.
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    Rheologica acta 29 (1990), S. 98-102 
    ISSN: 1435-1528
    Keywords: Fluid of differential type ; normal stresses ; thermodynamic consistency ; Trouton viscosity ; stability
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    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract A fairly simple generalization of the grade 2 fluid is described. However, unlike the grade 2 fluid, this fluid of differential type can accomodate extremely general viscometric data and still be consistent with commonly held ideas of energy dissipation and stability.
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    Celestial mechanics and dynamical astronomy 60 (1994), S. 307-315 
    ISSN: 1572-9478
    Keywords: Asteroid ; libration ; resonance ; stability
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    Topics: Physics
    Notes: Abstract It is known that an abridged case of the averaged planar general three-body problem, at first-order resonance, is analytically integrated, using an expansion of the disturbing function linear in the eccentricities. There exist different methods with the help of which the integration can be performed. For the first time Sessin and Ferraz-Mello in the years 1981–88 (Sessin, 1981, 1983; Ferraz-Mello and Sessin, 1984; Ferraz-Mello, 1987, 1988) did an analytic integration for the restricted elliptic three-body problem, in terms of the variablesK andH (K=ΣD j e j cos (ψ1−π j ),H=ΣD j e j sin (ψ1−π j ),D j = const, wheree j and π j are, respectively, the eccentricity and the longitude of the periapsis of thei-th planet, ψ1 is the Delaunay's anomaly), which is inconvenient for the analytical investigation of the evolution of the major semi-axesa j , the eccentricitiese j and the resonance phases ϕ j =ψ1−π j . Later, a different method for the analytical integration of the general three-body problem, in the variablesa j ,e j and ϕ j , was considered by the author (Shinkin, 1993). A disadvantage of both methods is the fact that they use non-canonical changes of variables. But there exists a third very beautiful canonical method of analytical integration of the general planetary problem, which is briefly considered in the present paper and allows us to describe the bifurcations of separatrices (i.e. appearance, disappearance, splitting and confluence of separatrices) separating the domains of libration and circulation of the resonance phase on the phase plane in the averaged planar general three-body problem at first-order resonance. The bifurcation parameter is analytically found and plays an important role in a qualitative description of all kinds of motion in the examined problem.
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    Journal of dynamics and differential equations 6 (1994), S. 325-334 
    ISSN: 1572-9222
    Keywords: Nonlinear Schrödinger equations ; anisotropic standing waves ; stability ; concentration compactness principle ; Davey-Stewartson system ; 35Q35 ; 35B35
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    Topics: Mathematics
    Notes: Abstract We study the stability of standing waves for a nonlinear Schrödinger equation, which derives from the generalized Davey-Stewartson system in the elliptic-elliptic case. We prove the existence of stable standing waves under certain conditions.
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    Journal of dynamics and differential equations 6 (1994), S. 447-486 
    ISSN: 1572-9222
    Keywords: Free boundary problems ; gasless combustion ; stability ; Hopf bifurcation ; 35R35 ; 35B40 ; 80A25
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper, we analyze a simple free boundary model associated with solid combustion and some phase transition processes. There is strong evidence that this “one-phase” model captures all major features of dynamical behavior of more realistic (and complicated) combustion and phase transition models. The principal results concern the dynamical behavior of the model as a bifurcation parameter (which is related to the activation energy in the case of combustion) varies. We prove that the basic uniform front propagation is asymptotically stable against perturbations for the bifurcation parameter above the instability threshold and that a Hopf bifurcation takes place at the threshold value. Results of numerical simulations are presented which confirm that both supercritical and subcritical Hofp bifurcation may occur for physically reasonable nonlinear kinetic functions.
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    Annals of operations research 27 (1990), S. 343-369 
    ISSN: 1572-9338
    Keywords: Bifurcation ; singularities ; continuation ; parametric nonlinear programming ; stability
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    Topics: Mathematics , Economics
    Notes: Abstract Bifurcation and continuation techniques are introduced as a class of methods for investigating the parametric nonlinear programming problem. Motivated by the Fritz John first-order necessary conditions, the parametric programming problem is first reformulated as a closed system of nonlinear equations which contains all Karush-Kuhn-Tucker and Fritz John points, both feasible and infeasible solutions, and relative minima, maxima, and saddle points. Since changes in the structure of the solution set and critical point type can occur only at singularities, necessary and sufficient conditions for the existence of a singularity are developed in terms of the loss of a complementarity condition, the linear dependence constraint qualification, and the singularity of the Hessian of the Lagrangian on a tangent space. After a brief introduction to elementary bifurcation theory, some simple singularities in this parametric problem are analyzed for both branching and persistence of local minima. Finally, a brief introduction to numerical continuation and bifurcation procedures is given to indicate how these facts can be used in a numerical investigation of the problem.
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    Queueing systems 15 (1994), S. 211-238 
    ISSN: 1572-9443
    Keywords: polling system ; stability ; Markov chain ; stochastic monotonicity ; heavy traffic ; nonpreemptive local priority
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper deals with the stability of periodic polling models with a mixture of service policies. Customers arrive according to independent Poisson processes. The service times and the switchover times are independent with general distributions. The necessary and sufficient condition for the stability of such polling systems is established. The proof is based on the stochastic monotonicity of the state process at the polling instants. The stability of only a subset of the queues is also analyzed and, in case of heavy traffic, the order of explosion of the queues is given. The results are valid for a model with set-up times, and also when there is a local priority rule at the queues.
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    Queueing systems 17 (1994), S. 317-345 
    ISSN: 1572-9443
    Keywords: Single-server queue ; spatially distributed arrival points ; travelling server ; Brownian motion ; embedded Markov chain ; stability ; Tweedie's lemma ; regenerative processes ; stochastic decomposition ; equilibrium equations ; mean queue length
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    Topics: Computer Science
    Notes: Abstract Consider a queueing system where customers arrive at a circle according to a homogeneous Poisson process. After choosing their positions on the circle, according to a uniform distribution, they wait for a single server who travels on the circle. The server's movement is modelled by a Brownian motion with drift. Whenever the server encounters a customer, he stops and serves this customer. The service times are independent, but arbitrarily distributed. The model generalizes the continuous cyclic polling system (the diffusion coefficient of the Brownian motion is zero in this case) and can be interpreted as a continuous version of a Markov polling system. Using Tweedie's lemma for positive recurrence of Markov chains with general state space, we show that the system is stable if and only if the traffic intensity is less than one. Moreover, we derive a stochastic decomposition result which leads to equilibrium equations for the stationary configuration of customers on the circle. Steady-state performance characteristics are determined, in particular the expected number of customers in the system as seen by a travelling server and at an arbitrary point in time.
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    Celestial mechanics and dynamical astronomy 56 (1993), S. 323-324 
    ISSN: 1572-9478
    Keywords: chaos ; stability ; asteroids
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    Topics: Physics
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    Celestial mechanics and dynamical astronomy 56 (1993), S. 51-68 
    ISSN: 1572-9478
    Keywords: Planetary orbits ; stability
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    Topics: Physics
    Notes: Abstract A comparison is made between the stability criteria of Hill and that of Laplace to determine the stability of outer planetary orbits encircling binary stars. The restricted, analytically determined results of Hill's method by Szebehely and co-workers and the general, numerically integrated results of Laplace's method by Graziani and Black are compared for varying values of the mass parameter μ=m 2/(m 1+m 2). For 0≤μ≤0.15, the closest orbit (lower limit of radius) an outer planet in a binary system can have and still remain stable is determined by Hill's stability criterion. For μ〉0.15, the critical radius is determined by Laplace's stability criterion. It appears that the Graziani-Black stability criterion describes the critical orbit within a few percent for all values of μ.
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    Celestial mechanics and dynamical astronomy 57 (1993), S. 59-94 
    ISSN: 1572-9478
    Keywords: asteroids ; libration ; proper elements ; stability ; chaos ; families
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    Topics: Physics
    Notes: Abstract I have computed proper elements for 174 asteroids in the 1 : 1 resonance with Jupiter, that is for all the reliable orbits available (numbered and multi-opposition). The procedure requires numerical integration, under the perturbations by the four major planets, for 1,000,000 years; the output is digitally filtered and compressed into a “synthetic theory” (as defined within theLONGSTOP project). The proper modes of oscillation of the variables related to eccentricity, perihelion, inclination and node define proper elements. A third proper element is defined as the amplitude of the oscillation of the semimajor axis associated with the libration period; because of the strong nonlinearity of the problem, this component cannot be determined by a simple Fourier transform to the frequency domain. I therefore give another definition, which results in very good stability with time. For 87% of the computed orbits, the stability of the proper elements-at least over 1M yr-is within the following bounds: 0.001AU in semimajor axis, 0.0025 in eccentricity and sine of inclination. Half of the cases with degraded stability of the proper elements are found to be chaotic, with e-folding times between 16,000 and 660,000yr; in some other cases, chaotic behaviour does not result in a significantly decreased stability of the proper elements (stable chaos). The accuracy and stability of these proper elements is good enough to allow a search for asteroid families; however, the dynamical structure of the Trojan belt is very different from the one of the main belt, and collisional events among Trojans can result in a distribution of fragments difficult to identify. The occurrence of couples of Trojans with very close proper elements is proven not to be statistically significant in almost all cases. As the only exception, the couple 1583 Antilochus — 3801 Thrasimedes is significant; however, it is not easy to account for it by a conventional collisional theory. The Menelaus group is confirmed as a strong candidate collisional family; Teucer and Sarpedon could be considered as significant clusters. A number of other clumps are detected (by the same automated clustering method used for the main belt by Zappalà et al., 1990, 1992), but the total number of Trojans with reliable orbits is not large enough to detect many significant candidate families.
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    Celestial mechanics and dynamical astronomy 60 (1994), S. 249-271 
    ISSN: 1572-9478
    Keywords: Chaos ; periodic orbits ; stability ; asymptotic curves ; homoclinic points ; heteroclinic points
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    Topics: Physics
    Notes: Abstract We study the structure of chaos in a simple Hamiltonian system that does no have an escape energy. This system has 5 main periodic orbits that are represented on the surface of section $$(y,\dot y)$$ by the points (1)O(0,0), (2)C 1,C 2(±y c, 0), (3)B 1,B 2(O,±1) and (4) the boundary $$y^2 + \dot y^2 = 1$$ . The periodic orbits (1) and (4) have infinite transitions from stability (S) to instability (U) and vice-versa; the transition values of ε are given by simple approximate formulae. At every transitionS →U a set of 4 asymptotic curves is formed atO. For larger ε the size and the oscillations of these curves grow until they destroy the closed invariant curves that surroundO, and they intersect the asymptotic curves of the orbitsC 1,C 2 at infinite heteroclinic points. At every transitionU →S these asymptotic curves are duplicated and they start at two unstable invariant points bifurcating fromO. At the transition itself the asymptotic curves fromO are tangent to each other. The areas of the lobes fromO increase with ε; these lobes increase even afterO becomes stable again. The asymptotic curves of the unstable periodic orbits follow certain rules. Whenever there are heteroclinic points the asymptotic curves of one unstable orbit approach the asymptotic curves of another unstable orbit in a definite way. Finally we study the tangencies and the spirals formed by the asymptotic curves of the orbitsB 1,B 2. We find indications that the number of spiral rotations tends to infinity as ε → ∞. Therefore new tangencies between the asymptotic curves appear for arbitrarily large ε. As a consequence there are infinite new families of stable periodic orbits that appear for arbitrarily large ε.
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    Journal of dynamics and differential equations 4 (1992), S. 161-190 
    ISSN: 1572-9222
    Keywords: Delay differential equations ; equilibrium ; stability ; limiting equations ; population dynamics ; 34K20 ; 34K25 ; 92A15
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Applying an analytical method and several limiting equations arguments, some sufficient conditions are provided for the existence of a unique positive equilibriumK for the delay differential equationx=−γx+D(x t ), which is the general form of many population models. The results are concerned with the global attractivity, uniform stability, and uniform asymptotic stability ofK. Application of the results to some known population models, which shows the effectiveness of the methods applied here, is also presented.
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    Journal of dynamics and differential equations 5 (1993), S. 105-128 
    ISSN: 1572-9222
    Keywords: Delay system ; stability ; relative variance ; dynamical disease
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    Topics: Mathematics
    Notes: Abstract A new approach to the study of delay systems, applicable to physiological control systems and other systems where little information about the time delays is available, is examined. The method is based on the fact that stability information can be deduced from the statistical properties of the probability distribution that encodes the structure of the time delay. The main statistical variables used are the usual expectation parameter,E, and a modified variance, calledrelative variance and denotedR, that is invariant under time scale changes. Recent work of the author has shown that stability often improves asR increases whileE remains fixed. A four-parameter family of delay models is analysed in this paper, and the (E, R) pair is found to be a reliable indicator of stability over the global parameter domain of the family.
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    Journal of dynamics and differential equations 6 (1994), S. 631-637 
    ISSN: 1572-9222
    Keywords: stability ; fixed point index ; periodic solutions
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    Topics: Mathematics
    Notes: Abstract In this paper, we prove that a stable isolated fixed point of an orientation preserving local homeomorphism onR 2 has fixed point index 1. We also give a number of applications to differential equations. In particular, we deduce that a number of existence methods for producing periodic solutions of differential equations in the plane always produce unstable solutions.
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    Journal of dynamics and differential equations 6 (1994), S. 639-658 
    ISSN: 1572-9222
    Keywords: Symmetry ; parabolic equations ; positive solutions ; stability
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    Topics: Mathematics
    Notes: Abstract Symmetry properties of positive solutions of a Dirichlet problem for a strongly nonlinear parabolic partial differential equation in a symmetric domainD ⊂ R n are considered. It is assumed that the domainD and the equation are invariant with respect to a group {Q} of transformations ofD. In examples {Q} consists of reflections or rotations. The main result of the paper is the theorem which states that any compact inC(D) negatively invariant set which consists of positive functions consists ofQ-symmetric functions. Examples of negatively invariant sets are (in autonomous case) equilibrium points, omega-limit sets, alpha-limit sets, unstable sets of invariant sets, and global attractors. Application of the main theorem to equilibrium points gives the Gidas-Ni-Nirenberg theorem. Applying the theorem to omega-limit sets, we obtain the asymptotical symmetrization property. That means that a bounded solutionu(t) asr→∞ approaches subspace of symmetric functions. One more result concerns properties of eigenfunctions of linearizations of the equations at positive equilibrium points. It is proved that all unstable eigenfunctions are symmetric.
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    Queueing systems 16 (1994), S. 115-137 
    ISSN: 1572-9443
    Keywords: Polling systems ; stability ; stochastic continuity ; general arrival process ; functional limit theorems.
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    Topics: Computer Science
    Notes: Abstract The stability of a polling system with exhaustive service and a finite number of users, each with infinite buffers is considered. The arrival process is more general than a Poisson process and the system is not slotted. Stochastic continuity of the stationary distributions, rates of convergence and functional limit theorems for the queue length and waiting time processes have also been proved. The results extend to the gated service discipline.
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    Journal of dynamics and differential equations 5 (1993), S. 189-218 
    ISSN: 1572-9222
    Keywords: Equivariant bifurcation ; symmetry ; singularity ; equivariant jets and transversality ; normal forms ; universal unfolding ; stability ; structural stability ; 58F14 ; 58E07 ; 58C27
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    Topics: Mathematics
    Notes: Abstract The theoretical machinery from singularity theory introduced by Golubitsky, Stewart, and Schaeffer, to study equivariant bifurcation problems, is completed and expanded while generalized to the multiple parameter context. In this setting the finite determinacy theorems or normal forms, the stability of equivariant bifurcation problems, and the structural stability of the universal unfolding are discussed.
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    Journal of dynamics and differential equations 6 (1994), S. 37-51 
    ISSN: 1572-9222
    Keywords: Celestial mechanics ; relative equilibria ; stability
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    Topics: Mathematics
    Notes: Abstract A criterion for the linear stability of relative equilibria of the Newtoniann-body problem is found in the case whenn−1 of the masses are small. Several stable periodic orbits of the problem are presented as examples.
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    Journal of dynamics and differential equations 5 (1993), S. 625-671 
    ISSN: 1572-9222
    Keywords: Scalar reaction-diffusion equation ; singular perturbation methods ; internal layer ; Neumann layer ; stability ; 35K57 ; 35B25 ; 35B35
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    Topics: Mathematics
    Notes: Abstract The multiple existences and their stability properties of stationary solutions with a single transition layer in some scalar reaction-diffusion equation are shown. Each solution is constructed by using classical singular perturbation methods and its stability property is determined by a simple algebraic quantity, say index, appearing in the construction of a solution.
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    Set-valued analysis 1 (1993), S. 393-402 
    ISSN: 1572-932X
    Keywords: Primary: 49J40, 65K10, 47A55, 47H05, 65L20 ; Variational inequality ; perturbation ; unbounded and nonsmooth operators ; convex sets ; Hausdorff distance ; regularization ; monotonicity ; convergence ; stability
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    Topics: Mathematics
    Notes: Abstract The stability and convergence of the solutions of perturbed and regularized variational inequality to the solutions of the primary (unstable a priori) variational inequality with proper monotone operator are investigated. All the objects of inequality: the operatorA, the right-hand partf and the set of constrains Ω are to be perturbed. At the same time no assumptions of boundedness and smoothness of the operatorA are used. The connection between the parameters of perturbations, which guarantees strong convergence of approximate solutions, is established. It is proved that the existence of the solution to the unperturbed variational inequality is necessary and sufficient condition for convergence of the regularized perturbed inequality solutions.
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    Queueing systems 12 (1992), S. 369-389 
    ISSN: 1572-9443
    Keywords: Perturbation analysis ; stability ; stochastic difference equations ; simulation
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    Topics: Computer Science
    Notes: Abstract We investigate the stability of waiting-time derivatives when inputs to a queueing system-service times and interarrival times-depend on a parameter. We give conditions under which the sequence of waiting-time derivatives admits a stationary distribution, and under which the derivatives converge to the stationary regime from all initial conditions. Further hypotheses ensure that the expectation of a stationary waiting-time derivative is, in fact, the derivative of the expected stationary waiting time. This validates the use of simulation-based infinitesimal perturbation analysis estimates with a variety of queueing processes. We examine waiting-time sequences satisfying recursive equations. Our basic assumption is that the input and its derivatives are stationary and ergodic. Under monotonicity conditions, the method of Loynes establishes the convergence of the derivatives. Even without such conditions, the derivatives obey a linear difference equation with random coefficients, and we exploit this fact to find stability conditions.
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    Queueing systems 15 (1994), S. 279-288 
    ISSN: 1572-9443
    Keywords: Sample-path ; point processes ; workload ; stability
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    Topics: Computer Science
    Notes: Abstract In this paper, by exploiting recent results on the pathwise behavior of the workload process in single server, work conserving queues of theG/G/1/∞ type, we show that the workload of multiserver, work conserving queues ofG/G/m/∞ (m〈∞) (andG/G/∞) queues satisfies an o(t) growth condition, provided that the time average of the work brought into the system is less thanm form 〈 ∞ (and finite form=∞).
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    Queueing systems 11 (1992), S. 7-33 
    ISSN: 1572-9443
    Keywords: Token passing rings ; stability ; substability ; ergodicity ; Markov chains ; Loynes' scheme ; stochastically dominant ; Little's formula ; regenerative processes
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    Topics: Computer Science
    Notes: Abstract A sufficient stability condition for the standard token passing ring has been “known” since the seminal paper by Kuehn in 1979. However, this condition was derived without formal proof, and the proof seems to be of considerable interest to the research community. In fact, Watson observed that in the performance evaluation of token passing rings, “it is convenient to derive stability conditions ... (without proof)”. Our intention is to fill this gap, and to provide a formal proof of thesufficient and necessary stability condition for the token passing ring. In this paper, we present the case when the arrival process to each queue is Poisson but service times and switchover times are generally distributed. We consider in depth a gatedl-limited (l≤ ∞) service discipline for each station. We also indicate that the basic steps of our technique can be used to study the stability of some other multiqueue systems.
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    Queueing systems 6 (1990), S. 335-351 
    ISSN: 1572-9443
    Keywords: State-dependent service and interarrival times ; Lindley equation ; recursive stochastic equations ; stability ; stochastic comparisons ; normal approximations ; scheduling arrivals
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    Topics: Computer Science
    Notes: Abstract We consider a modification of the standardG/G/1 queue with unlimited waiting space and the first-in first-out discipline in which the service times and interarrival times depend linearly and randomly on the waiting times. In this model the waiting times satisfy a modified version of the classical Lindley recursion. We determine when the waiting-time distributions converge to a proper limit and we develop approximations for this steady-state limit, primarily by applying previous results of Vervaat [21] and Brandt [4] for the unrestricted recursionY n+1=C n Y n +X n . Particularly appealing for applications is a normal approximation for the stationary waiting time distribution in the case when the queue only rarely becomes empty. We also consider the problem of scheduling successive interarrival times at arrival epochs, with the objective of achieving nearly maximal throughput with nearly bounded waiting times, while making the interarrival time sequence relatively smooth. We identify policies depending linearly and deterministically upon the work in the system which meet these objectives reasonably well; with these policies the waiting times are approximately contained in a specified interval a specified fraction of time.
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    Order 9 (1992), S. 163-175 
    ISSN: 1572-9273
    Keywords: Primary 06A07 ; secondary 05C70 ; Partial order ; interval ; stability ; covering ; Sperner property ; symmetric chains ; NP-completeness
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    Topics: Mathematics
    Notes: Abstract Given a finite ranked posetP, let α(P) be the maximum size of a subset ofP such that no two elements of it belong simultaneously to some interval ofP and let ϱ(P) be the minimum number of intervals covering all elements ofP. We say thatP has the strong interval stability property (resp. the strong interval covering property) if for each subposetP′ induced by consecutive levels ofP, i.e.,P′=P (l)∪...∪P (u), one has α(P′)=max{|P (l)|, |P (u)|} (resp. ϱ(P′)=max{|P (l)|, |P (u)|}). We prove these properties for several classes of posets and discuss some general facts concerning the numbers α(P) and ϱ(P), e.g., NP-completeness and min-max relations.
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    Queueing systems 13 (1993), S. 87-110 
    ISSN: 1572-9443
    Keywords: Manufacturing systems ; semiconductor manufacturing ; thin film lines ; re-entrant lines ; scheduling policies ; queueing networks ; buffer priority policies ; due date policies ; stability ; stochastic control ; mean delay ; variance of delay ; machine failures ; set-up times
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    Topics: Computer Science
    Notes: Abstract Traditionally, manufacturing systems have mainly been treated as either job shops or flow shops. In job shops, parts may arrive with random routes, with each route having a low volume. In flow shops, the routes are fixed and acyclic, as in assembly lines. With the advent of semiconductor manufacturing plants, and more recently, thin film lines, this dichotomy needs to be expanded to consider another class of systems, which we call “re-entrant lines”. The distinguishing feature of these manufacturing systems is that parts visit some machines more than once at different stages of processing. Scheduling problems arise because several parts at different stages of processing may be in contention with each other for service at the same machine. There may be uncertainties in the form of random service or set-up times, as well as random machine failures and repairs. The goal of scheduling is to improve performance measures such as mean sojourn time in the system, which is also known as the mean “cycle-time”, or the variance of the cycle-time. In this paper we provide a tutorial account of some recent results in this field. We describe several scheduling policies of interest, and provide some results concerning their stability and performance. Several open problems are suggested.
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    Queueing systems 14 (1993), S. 159-175 
    ISSN: 1572-9443
    Keywords: Queueing networks ; nonproduct form networks ; stability ; stochastic continuity ; functional limit theorems
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    Topics: Computer Science
    Notes: Abstract A finite number of nodes, each with a single server and infinite buffers, is considered in discrete time. The service may be FIFO and the service times are constant. The external arrivals and the routing decision variables form a general stationary sequence. Stability of the system is proved under these assumptions. Extension to multiple servers at a node and general stationary distributions holds. If the external input is i.i.d. and the routing is Markovian then stochastic ordering, continuity of stationary distributions, rates of convergence, a functional CLT and a functional LIL and various other limit theorems for the queue length process are also proved. Generalizations to multiple servers at nodes, customers with priority, multiple customer classes, general service length and Markov modulated external arrival cases are discussed.
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    Catalysis letters 10 (1991), S. 225-232 
    ISSN: 1572-879X
    Keywords: VPI-5 ; stability ; molecular sieve ; post-synthesis treatments
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    Topics: Chemistry and Pharmacology
    Notes: Abstract Thorough washing of a VPI-5 synthesized with n-dipropylamine as template improves greatly its thermal stability while no major change is observed in the template content. A detailed study of the influence of the pretreatment conditions shows that in order to obtain a high thermal stability (up to at least 960 °C) two parameters are of importance. The removal of both the template and the adsorbed water requires either a low heating rate at atmospheric pressure or a low pressure (less than 3 Torr) when the heating rate is 300 ° per hour.
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    BIT 32 (1992), S. 634-649 
    ISSN: 1572-9125
    Keywords: AMS(MOS): 65L20 ; CR: 5.17 ; delay differential equations ; numerical solution ; Runge-Kutta methods ; interpolation procedures ; stability
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    Topics: Mathematics
    Notes: Abstract This paper deals with adapting Runge-Kutta methods to differential equations with a lagging argument. A new interpolation procedure is introduced which leads to numerical processes that satisfy an important asymptotic stability condition related to the class of testproblemsU′(t)=λU(t)+μU(t−τ) with λ, μ ε C, Re(λ)〈−|μ|, and τ〉0. Ifc i denotes theith abscissa of a given Runge-Kutta method, then in thenth stept n−1→t n :=t n−1+h of the numerical process our interpolation procedure computes an approximation toU(t n−1+c i h−τ) from approximations that have already been generated by the process at pointst j−1+c i h(j=1,2,3,...). For two of these new processes and a standard process we shall consider the convergence behaviour in an actual application to a given, stiff problem.
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    BIT 33 (1993), S. 74-84 
    ISSN: 1572-9125
    Keywords: 65J10 ; 65M12 ; Analytic semigroup ; Banach space ; rational approximation ; A-acceptable ; A(θ)-acceptable ; stability ; Crank-Nicolson method
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    Topics: Mathematics
    Notes: Abstract It is shown thatA-acceptable and, more generally,A(θ)-arational approximations of bounded analytic semigroups in Banach space are stable. The result applies, in particular, to the Crank-Nicolson method.
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    BIT 30 (1990), S. 332-346 
    ISSN: 1572-9125
    Keywords: 65D05 ; polynomial interpolaton ; Newton form ; stability ; Leja points ; ordering of interpolation points
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    Topics: Mathematics
    Notes: Abstract The Newton form is a convenient representation for interpolation polynomials. Its sensitivity to perturbations depends on the distribution and ordering of the interpolation points. The present paper bounds the growth of the condition number of the Newton form when the interpolation points are Leja points for fairly general compact sets K in the complex plane. Because the Leja points are defined recursively, they are attractive to use with the Newton form. If K is an interval, then the Leja points are distributed roughly like Chebyshev points. Our investigation of the Newton form defined by interpolation at Leja points suggests an ordering scheme for arbitrary interpolation points.
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    BIT 34 (1994), S. 62-79 
    ISSN: 1572-9125
    Keywords: AMS(MOS) 65D30 ; 65B05 ; adaptive ; cubature ; singularity ; extrapolation ; stability
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    Topics: Mathematics
    Notes: Abstract A new approach to the integration of vertex singularities is described. This approach is based on a non-uniform subdivision of the region of integration and the technique fits well to the subdivision strategy used in many adaptive algorithms. A nice feature with this approach is that it can be used in any dimension and on any region of integration which can be subdivided into subregions of the same form. The strategy can be applied both to vertex singularities and internal point singularities. In the latter case this can be done without an initial subdivision of the region in order to put the singular point in a vertex. It turns out that the technique has excellent numerical stability properties.
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    Acta applicandae mathematicae 28 (1992), S. 1-42 
    ISSN: 1572-9036
    Keywords: 35R30 ; Inverse scattering ; stability ; noisy data
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    Topics: Mathematics
    Notes: Abstract An algorithm is given for calculating the solution to the 3D inverse scattering problem with noisy discrete fixed energy data. The error estimates for the calculated solution are derived. The methods developed are of a general nature and can be used in many applications: in nondestructive evaluation and remote sensing, in geophysical exploration, medical diagnostics, and technology.
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    Annals of global analysis and geometry 11 (1993), S. 221-235 
    ISSN: 1572-9060
    Keywords: Second variation formula ; Morse index ; stability ; 53C
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    Topics: Mathematics
    Notes: Abstract Iff is a minimal, isometric immersion of the Riemannian manifoldM of dimensionn in a Riemannian manifold $$\overline M$$ of dimensionm and ifI N is the „differential Jacobi operator” acting on the cross sections of the normal bundleN(M), we obtain some information on the Morse index and on the stability ofM through a detailed geometric analysis of the immersionf obtained when considering the higher fundamental forms off.
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    Annals of global analysis and geometry 11 (1993), S. 387-395 
    ISSN: 1572-9060
    Keywords: Curvatures of hypersurfaces ; Reilly's inequality ; stability ; 53 A 10 ; 53 C 42
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    Topics: Mathematics
    Notes: Abstract We generalize Reilly's inequality for the first eigenvalue of immersed submanifolds ofIR m +1 and the total (squared) mean curvature, to hypersurfaces ofIR m +1 and the first eigenvalue of the higher order curvatures. We apply this to stability problems. We also consider hypersurfaces in hyperbolic space.
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    BIT 33 (1993), S. 285-303 
    ISSN: 1572-9125
    Keywords: 65L05 ; stiffness ; stability ; pseudospectra
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    Topics: Mathematics
    Notes: Abstract It is argued that even for a linear system of ODEs with constant coefficients, stiffness cannot properly be characterized in terms of the eigenvalues of the Jacobian, because stiffness is a transient phenomenon whereas the significance of eigenvalues is asymptotic. Recent theory from the numerical solution of PDEs is adapted to show that a more appropriate characterization can be based upon pseudospectra instead of spectra. Numerical experiments with an adaptive ODE solver illustrate these findings.
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    Celestial mechanics and dynamical astronomy 49 (1990), S. 249-264 
    ISSN: 1572-9478
    Keywords: Solar sails ; radiation pressure ; stability
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    Topics: Physics
    Notes: Abstract The form of the solar radiation pressure on a heliocentric orbiting solar sail is obtained for a finite angular sized and limb darkened solar disk by the use of the radiation pressure tensor. It is found that the usual inverse square variation of the solar radiation pressure is modified by the finite angular size, and to a lesser extent by the solar limb darkening. The actual magnitude of the modification is in itself small, except at close heliocentric distances. However, its existence has implications for the dynamical stability of solar sails both in parked and circular orbital configurations and for the accuracy of trajectory calculations, particularly for sails in the inner solar system.
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    Celestial mechanics and dynamical astronomy 55 (1993), S. 249-259 
    ISSN: 1572-9478
    Keywords: Asteroid ; libration ; resonance ; stability
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    Topics: Physics
    Notes: Abstract This paper investigates the stability of the motion in the averaged planar general three-body problem in the case of first-order resonance. The equations of the averaged motion of bodies near the resonance surface is obtained and is analytically integrated by quadratures. The stability of the averaged motion is analytically investigated in relation to the semi-major axes, the eccentricities and the resonance phases. An autonomous second-order equation is obtained for the deviation of semiaxes from the resonance surface. This equation has an energy integral and is analytically integrated by quadratures. The quasi-periodic dependence on time with two-frequency basis of the averaged motion of bodies is found. The basic frequencies are analytically calculated. With the help of the mean functionals calculated along integral curves of the averaged problem the new analytic first integrals are constructed with coefficients periodic in time. The analytic conditions of librations of resonance phases are obtained.
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    Celestial mechanics and dynamical astronomy 55 (1993), S. 351-367 
    ISSN: 1572-9478
    Keywords: Sitnikov's problem ; invariant rotational curves ; stability
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    Topics: Physics
    Notes: Abstract The Sitnikov's Problem is a Restricted Three-Body Problem of Celestial Mechanics depending on a parameter, the eccentricity,e. The Hamiltonian,H(z, v, t, e), does not depend ont ife=0 and we have an integrable system; ife is small the KAM Theory proves the existence of invariant rotational curves, IRC. For larger eccentricities, we show that there exist two complementary sequences of intervals of values ofe that accumulate to the maximum admissible value of the eccentricity, 1, and such that, for one of the sequences IRC around a fixed point persist. Moreover, they shrink to the planez=0 ase tends to 1.
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    Celestial mechanics and dynamical astronomy 60 (1994), S. 99-129 
    ISSN: 1572-9478
    Keywords: Sitnikov motions ; periodic orbits ; stability ; bifurcations
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    Topics: Physics
    Notes: Abstract In this paper we deal with the circular Sitnikov problem as a subsystem of the three-dimensional circular restricted three-body problem. It has a first analytical part where by using elliptic functions we give the analytical expressions for the solutions of the circular Sitnikov problem and for the period function of its family of periodic orbits. We also analyze the qualitative and quantitative behavior of the period function. In the second numerical part, we study the linear stability of the family of periodic orbits of the Sitnikov problem, and of the families of periodic orbits of the three-dimensional circular restricted three-body problem which bifurcate from them; and we follow these bifurcated families until they end in families of periodic orbits of the planar circular restricted three-body problem. We compare our results with the previous ones of other authors on this problem. Finally, the characteristic curves of some bifurcated families obtained for the mass parameter close to 1/2 are also described.
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    Celestial mechanics and dynamical astronomy 55 (1993), S. 323-330 
    ISSN: 1572-9478
    Keywords: Periodic orbits ; rigid body dynamics ; stability
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    Topics: Physics
    Notes: Abstract The equations of motion of a rigid body about a fixed point in a central Newtonian field is reduced to the equation of plane motion under the action of potential and gyroscopic forces, using the isothermal coordinates on the inertia ellipsoid. The construction of periodic solutions near the equilibrium points, by using the Lipaunov theorem of holomorphic integral, is obtained and the necessary and sufficient conditions for the stability of the system are given.
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    Celestial mechanics and dynamical astronomy 49 (1990), S. 219-231 
    ISSN: 1572-9478
    Keywords: n-body problem ; stability ; relative equilibrium
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    Topics: Physics
    Description / Table of Contents: Abstract We prove in this paper the instability, for all n ⩾ 4, of the configurations of relative equilibrium in the n-body problem where the n bodies submitted to newtonian mutual attractions are at the vertices of a regular polypon with n sides. For this proof we show that the equations of variations projected to the n bodies plan P have at least two conjugate characteristic exponents with a strictly positive real part; while these equations projected to an orthogonal axis to P have some solutions with secular terms.
    Notes: Resumé On démontre dans cet article l'instabilité, pour tout n ⩾ 4, des configurations d'équilibre relatif dans le problème des n corps, oú les n corps soumises aux attractions newtonniennes mutuelles se trouvent aux sommets d'un polygone régulier de n cotés. La preuve consiste à montrer que les équations aux variations, projetées sur le plan P des n corps, possèdent au moins deux exposants caractéristiques complexes connugués dont la parr'e réelle est strictement positive; alors que ces equations projetées sur un axe orthogonal à P possèdent des solutions ayant des termes séculaires.
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    BIT 33 (1993), S. 332-350 
    ISSN: 1572-9125
    Keywords: AMS(MOS): 65L06 ; Multistep collocation method ; continuous solution ; stability
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    Topics: Mathematics
    Notes: Abstract This paper describes an implementation of multistep collocation methods, which are applicable to stiff differential problems, singular perturbation problems, and D.A.E.s of index 1 and 2. These methods generalize one-step implicit Runge-Kutta methods as well as multistep one-stage BDF methods. We give numerical comparisons of our code with two representative codes for these methods, RADAU5 and LSODE.
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  • 83
    ISSN: 1573-904X
    Keywords: cyclodextrines ; cyclodextrin derivatives ; indomethacin ; stability ; 1H-NMR.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect of various cyclodextrins (CD) and cyclodextrin derivatives on indomethacin stability in phosphate buffer, pH 7.4, was investigated. The influence of CD-ring size, type of substituent, degree of substitution, substitution pattern, and influence of CD concentration were monitored. The indomethacin complex in solution was studied by 1H-NMR spectroscopy to develop a molecular inclusion model. The most favorable ring size for the stabilization of indomethacin was the β-CD. The β-CD derivatives inhibited the hydrolysis of indomethacin more effectively than the parent CD. Among the studied CD derivatives, those with lipophilic substituents, such as ethyl or methyl, were superior to those with hydrophilic substitutents. The more hydroxyl groups of the glucose moiety are substituted, the better is the stabilizing effect. Further, the p-chlorobenzoic part of the indomethacin molecule is included in the CD channel.
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    ISSN: 1573-904X
    Keywords: ibutilide ; shelf life ; stability ; Arrhenius analysis ; nucleophilic substitution
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    Topics: Chemistry and Pharmacology
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    Pharmaceutical research 9 (1992), S. 1521-1523 
    ISSN: 1573-904X
    Keywords: salmon calcitonin ; stability ; kinetics ; peptide ; degradation ; pH–rate profile ; HPLC
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    Topics: Chemistry and Pharmacology
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    Pharmaceutical research 9 (1992), S. 939-944 
    ISSN: 1573-904X
    Keywords: calorimetry ; microcalorimetry ; stability ; kinetics, solid state ; degradation
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    Topics: Chemistry and Pharmacology
    Notes: Abstract A new technique has been developed to calculate rapidly the solid-state room-temperature degradation rate of drugs and drug candidates. The technique utilizes measurements of the initial rate of heat output at several elevated temperatures by isothermal calorimetry and the degradation rate of the compound determined at a single elevated temperature by chromatography. The activation energies and degradation rates at 25°C calculated by conventional methods and by isothermal calorimetry are compared and discussed. The compounds studied were phenytoin, triamterene, digoxin, tetracycline, theophylline, diltiazem, and several proprietary ICI compounds.
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    Pharmaceutical research 8 (1991), S. 547-549 
    ISSN: 1573-904X
    Keywords: hydrocortisone 17-butyrate ; steroids ; stability ; topical cream ; high-performance liquid chromatography (HPLC)
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    Topics: Chemistry and Pharmacology
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  • 88
    ISSN: 1573-904X
    Keywords: 2-hydroxypropyl-β-cyclodextrin ; ovine growth hormone ; interleukin-2 ; insulin ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A chemically modified, amorphous β-cyclodextrin, namely, 2-hydroxypropyl-β-cyclodextrin (HPCD), was examined as a solubilizing and stabilizing agent for protein drugs. The aqueous solubility of ovine growth hormone at pH 7.4 was increased through the use of HPCD. This effect was manifested by higher UV transparency at 600 nm. Interleukin-2 (IL-2) is rendered insoluble upon lyophilization in the absence of stabilizers. Use of aqueous HPCD provides a clear solution, as indicated by fluorometric light scattering, and inhibits aggregate formation, as shown by ultracentrifugation and Western blot analyses. In addition, there were no major conformational changes of IL-2 in HPCD formulation as indicated by fourth-derivative ultraviolet spectroscopy. Finally, IL-2 retained 100% of its biopotency when prepared in HPCD solutions. Aggregation of insulin was also suppressed by HPCD. These data, as well as the i.v. safety of HPCD and its well-characterized chemical composition, suggest that this starch derivative may be a potentially useful excipient for protein drugs intended for parenteral use.
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  • 89
    ISSN: 1573-904X
    Keywords: liposome ; differential scanning calorimetry (DSC) ; stability ; freezing/thawing ; cryopreservation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The thermal behavior of water in liposome dispersions and in liposome dispersions containing mannitol at subzero temperatures was investigated with differential scanning calorimetry (DSC). The cooling curves from 20 down to - 60°C for a liposome dispersion (bilayer composition PL100H/DCP), monitored at cooling rates of 5 and 10°C/min, showed several heat flows related to water crystallization. All lipid-containing dispersions showed water crystallization at temperatures below −40°C. The magnitude of this heat flow strongly depended on the experimental variables. Cooling rate, particle size, lipid concentration, and location and nature of the cryoprotectant all influenced the water crystallization behavior as shown in the DSC cooling curve. Different fractions of water–presumably related to their location in the dispersion–could be distinguished. It is concluded that DSC provides a valuable tool for the detection of changes in the physical state of water in liposome dispersions during freezing/thawing. The insights gained from these DSC studies may make it possible to select–on the basis of rational considerations rather than by trial and error–optimum conditions for the cryopreservation of liposomes containing water-soluble drugs.
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  • 90
    ISSN: 1573-904X
    Keywords: monoclonal antibody ; lyophilization ; freeze-drying ; stability ; formulation ; cyclodextrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The influence of lyophilization on the stability of a monoclonal antibody (MN12) was investigated. MN12 was freeze-dried in different formulations [without lyoprotectant or in the presence of sucrose, dextran, or hydroxypropyl-β-cyclodextrin (HPβCD)] and under varying conditions (with or without secondary drying). Subsequently, the monoclonal antibody was stored for 18 or 32 days at various temperatures (4, 37, or 56°C). For comparison, solutions of MN12 were stored under the same conditions. Regardless of the lyoprotectant used, precipitation and a concomitant reduction of the antigen-binding capacity by about 10% were observed upon recon-stitution of lyophilized MN12. HPβCD proved to be the most effective stabilizer to prevent degradation of lyophilized MN12 during storage. Compared with MN12 solutions, HPβCD-containing lyophilized MN12 cakes were more resistant to heat-induced charge alterations and loss of antigen-binding capacity.
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  • 91
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    Pharmaceutical research 9 (1992), S. 312-315 
    ISSN: 1573-904X
    Keywords: controlled drug delivery system ; chronotherapeu-tics ; electrically modulated ; electrophoresis ; degradation of propranolol hydrochloride ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A number of factors affecting the stability of propranolol HC1 during electrophoretic control were investigated. It was found that significant degradation of propranolol HC1 and hydrolysis of water occurred when a current of 15 mA was used with platinized electrodes. This degradation was thought to be due to decomposition of propranolol HC1 at the electrodes. Degradation could be significantly reduced by using uncoated platinum electrodes and currents in the range of 0 to 2.5 mA, while still allowing control of drug delivery rates. Electrode reaction processes were found at high ionic strengths and high drug concentrations but were not thought to be associated with drug decomposition.
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  • 92
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    Pharmaceutical research 9 (1992), S. 406-409 
    ISSN: 1573-904X
    Keywords: centrifugation ; emulsification ; perfluorocarbon ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect of preparation temperature on the emulsification efficiency of perfluoro-3-butyltetrahydrofuran (FC-75) was investigated. Polyoxyethylene (POE) oleyl ether surfactants were used as the emulsifier(s) in a range of HLB values of 7.5 to 9.5. The emulsions were prepared by paddle mixing as a method of low-shear emulsification. After centrifugation of the resulting O/W emulsions, the volume of FC-75 which separated was utilized as a measure of the emulsification efficiency. In general, emulsions prepared at temperatures where the surfactant was in a lamellar-to-isotropic surfactant solution transition, Lα→ L3, displayed a better emulsification efficiency than those prepared with other surfactant phases.
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  • 93
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    Pharmaceutical research 10 (1993), S. 1466-1470 
    ISSN: 1573-904X
    Keywords: p-chloro-m-xylenol ; 4-chloro-3,5-dimethylphenol (PCMX) ; radiolabel synthesis ; isotopes ; stability ; reaction kinetics ; in vitro studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The synthesis, reaction kinetics, and pH stability of isotopically labeled p-chloro-m-xylenol (PCMX) were evaluated. While base catalysis was more rapid than acid catalysis, the latter allowed the use of a cosolvent for deuterium and tritium labeling using as little as 250 µL labeled water. Both acid and base catalysis were markedly more rapid than that reported previously for the deuteration of PCMX and related phenols. Isotopic labeling occurred only at the 2 and 6 ring positions, ortho to the phenolic group of PCMX. No deuterium loss was observed after storage for 21 days at 37°C over a pH range of 2 – 14. Isotopic loss was observed only below pH 2. The prepared 3H-labeled PCMX had a specific activity of 1.18 mCi/mmol, a radiochemical purity of 99.0%, and a chemical purity exceeding 99.0%, with a high stability during prolonged cold storage.
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  • 94
    ISSN: 1573-904X
    Keywords: α-chymotrypsin ; fatty acid ; insulin ; mixed micelles ; proteolytic degradation ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The proteolytic degradation of porcine zinc insulin by α-chymotrypsin was previously found to depend markedly on the state of insulin aggregation (Pharm. Res. 9:864–869, 1992). In this study, the effect of bile salt-unsaturated fatty acid mixed micelles on α-chymotryptic degradation of insulin was further characterized. The incorporation of linoleic acid has greatly accelerated insulin degradation with the apparent first order rate constant being linearly related to the concentration of linoleic acid. At a 10 mM linoleic acid concentration solubilized in 10 mM sodium glycocholate, the proteoly tic degradation rate constant increased by 16 times, which could not be explained solely by the mechanism of insulin oligomer dissociation. Further, this effect is significantly reduced when the free carboxylic group of linoleic acid is methylated. The catalytic role of mixed micelles on chemical degradation of insulin was found to depend on the concentration of linoleic acid incorporated. When solubilized in the form of mixed micelles, linoleic acid chemically catalyzes peptide bond cleavage in a concentration-dependent manner.
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  • 95
    ISSN: 1573-904X
    Keywords: emulsions ; stability ; field-flow fractionation ; size distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The combination of sedimentation field-flow fractionation (SedFFF) and photon correlation spectroscopy (PCS) is shown to provide a detailed record of the droplet sizes present in fat emulsions commonly used in parenteral nutrition. The technique presented has been used to record size distribution data for a particular emulsion (Liposyn-II), demonstrating its high stability and lot-to-lot uniformity. The technique is also able to demonstrate how additions of small amounts of electrolytes [0.45% (w/v) NaCl, 0.05% (w/v) CaCl2] tend to destabilize the emulsion, suggesting some caution in the use of total parenteral nutrition (TPN) mixtures. In contrast, a 1:1 mixture with human serum caused no sign of instability in the Liposyn-II. Using the emulsion as a carrier for lipophilic drugs necessitates adding solutions of the drug in nonaqueous solvents, such as DMSO (dimethyl sulfoxide). This solvent's destabilizing effect results in a droplet coalescence that becomes severe after 3–5 days following a 10% (v/v) addition, while a 5% (v/v) addition reaches the same level of coalescence in 10 days.
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  • 96
    ISSN: 1573-904X
    Keywords: peptides ; liquid crystals ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 97
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    Pharmaceutical research 10 (1993), S. 1174-1180 
    ISSN: 1573-904X
    Keywords: aspartame ; stability ; pH – rate profile ; peptide ester ; hydrolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The kinetics of demethylation of aspartame and L-phenylalanine methyl ester were studied in aqueous solution at 25°C over the pH range 0.27–11.5. The pseudo-first-order rate constant for aspartame was resolved into individual contributions from methyl ester hydrolysis and diketopiperazine formation. pH – rate profiles were quantitatively described by chemically reasonable kinetic schemes. Aspartame is maximally stable at pH 4 (t 90 = 53 days at 25°C); phe-nylalanine methyl ester, at pH 3. The potentiometrically measured pK a values were pK a1 3.19 and pK a2 7.87 fr aspartame and pKa 7.11 for phenylalanine methyl ester.
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  • 98
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    Pharmaceutical research 10 (1993), S. 156-159 
    ISSN: 1573-904X
    Keywords: aspirin ; hydroxypropyl-β-cyclodextrin ; complexation ; stability ; activation energies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 99
    ISSN: 1573-904X
    Keywords: biodegradation ; stability ; α-chymotrypsin ; cyclodextrins ; enteral absorption ; histology ; insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The relative effectiveness of two β-cyclodextrin derivatives, i.e., dimethyl-β-cyclodextrin (DMβCD) and hydroxypropyl-β-cyclodextrin (HPβCD), in enhancing enteral absorption of insulin was evaluated in the lower jejunal/upper ileal segments of the rat by means of an in situ closed loop method. The incorporation of 10% (w/v) DMβCD to a 0.5 mg/ml porcine-zinc insulin solution dramatically increased insulin bioavailability from a negligible value (~0.06%) to 5.63%, when administered enterally at a dose of 20 U/kg. However, addition of 10% (w/v) HPβCD did not improve enteral insulin uptake significantly with a bioavailability of only 0.07%. Similarly, the pharmacodynamic relative efficacy values obtained after the enteral administration of 20 U/kg insulin, 20 U/kg insulin with 10% HPβCD, and 20 U/kg insulin with 10% DMβCD were 0.24%, 0.26%, and 1.75%, respectively. Biodegradation studies of 0.5 mg/ml insulin hexamers by 0.5 µM α-chymotrypsin revealed no inhibitory effect on the enzymatic activity by the two cyclodextrins. On the contrary, the apparent first-order rate constant increased significantly in the presence of 10% DMβCD, suggesting insulin oligomer dissociation by DMβCD. Histopathological examination of the rat intestine was performed to detect tissue damage following enteral administration of the β-cyclodextrin derivatives. Light microscopic inspection indicated no observable tissue damage, thereby arguing direct membrane fluidization as the primary mechanism for enhanced insulin uptake. This study indicates the feasibility of using cyclodextrins as mucosal absorption promoters of proteins and peptide drugs.
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  • 100
    ISSN: 1573-904X
    Keywords: cyclodextrin ; equilibrium model ; nasal delivery ; peptides ; peptidase ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Leucine enkephalin (YGGFL) undergoes rapid degradation in sheep nasal mucosa to yield GGFL which is further degraded to FL. The activity of the nasal mucosal homogenate against YGGFL and GGFL (t1/212 and 7 min) was significantly greater than that observed with a nasal wash fluid (t1/2 40 and 13 min). The effect of cyclodextrins on the rate of degradation of FGG and YGGFL by leucine aminopeptidase (LAP) and of GGF by carboxypeptidase A (CPA) was monitored. Little effect was observed with FGG (with LAP) but the half-life of YGGFL (with LAP) was extended from ~44 min to ~75 min in the presence of a 25-fold excess of β-cyclodextrin. The stability of GGF (with CPA) was also enhanced; an effect was observable with a 5-fold excess of cyclodextrin and the half-life could be extended by 40–75%. An equation is presented which allows the estimation of the concentration of free peptide in the peptide-cyclodextrin solutions.
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