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  • Q1-390  (1,489)
  • thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology  (1,259)
  • English  (2,743)
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  • 1
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: Anthropogenic greenhouse gas (GHG) emissions are dramatically influencing the environment, and research is strongly committed to proposing alternatives, mainly based on renewable energy sources. Low GHG electricity production from renewables is well established but issues of grid balancing are limiting their application. Energy storage is a key topic for the further deployment of renewable energy production. Besides batteries and other types of electrical storage, electrofuels and bioderived fuels may offer suitable alternatives in some specific scenarios. This Special Issue includes contributions on the energy conversion technologies and use, energy storage, technologies integration, e-fuels, and pilot and large-scale applications.
    Keywords: Q1-390 ; QC1-999 ; n/a ; PV ; GHG savings ; lithium-ion battery (LIB) ; probability prediction ; decarbonization ; supercapacitor (SC) ; least squares support vector machine ; EV fleet forecasts ; alternative maritime power (AMP) ; Markov chain ; feasibility study ; D funding ; hybrid power system ; numerical analysis ; ship structure ; optimal sizing ; cellulosic ethanol ; electric vehicles EV ; biofuel ; green ship ; R&amp ; bulk carrier ; molten carbonate fuel cell system ; sparse Gaussian process regression ; power-to-gas ; combination method ; charging infrastructure ; jet fuel ; flow characteristics ; hybrid refinery ; LNG-fueled ship ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 3
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the fascination with shape memory alloys (SMAs) has grown across industries such as aerospace, automotive, naval, civil, and biology. SMAs possess unique properties, including the ability to recover from deformation when heated, exhibit pseudoelastic stress-strain behavior for large deformations, and exceptional biocompatibility for bioengineering applications. However, a comprehensive understanding of critical characteristics like transformation temperature and stress values is necessary to fully utilize SMAs. The shape memory effect, where SMAs regain their original shape after deformation under specific thermal conditions, has driven innovative applications in various sectors. In aerospace, SMAs are used in wing structures and actuation systems, enabling morphing and improving aerodynamics. In healthcare, they are integrated into orthopedic devices, simplifying surgical procedures and providing necessary support. The automotive industry also benefits from SMAs, using them in seatbelts and vibration damping systems for enhanced safety and comfort. Accurate knowledge of critical characteristics is essential for effective utilization of SMAs, unlocking their potential in different fields. The remarkable versatility of SMAs, with their deformation recovery, pseudoelasticity, and biocompatibility, positions them as a material of immense interest. As research and development continue, SMAs are poised to drive future innovations, shaping various industries.
    Keywords: shape memory alloy (SMAs) ; shape memory effect (SME) ; superelasticity ; smart materials ; constitutive models ; simulation and modeling ; smart devices ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mg alloy is the lightest metallic structural material and possesses the advantages of high specific strength, high specific stiffness, good electromagnetism shield, good damping capacity, good machinability, and easy recycling, etc. Therefore, it has extremely broad application prospects and has drawn considerable interest in the fields of automobile, electronics, electrical appliances, transportation, aerospace, and aviation. In addition, Mg alloys are gradually showing application potential in emerging industries, serving as biodegradable metals in the biomedical field, functional material for hydrogen storage, and so on. This Special Issue (SI), entitled “Research Progress in High-Performance Magnesium Alloy and Its Applications”, presents recent developments and excellent results in the field of Mg alloys, and includes 10 articles and one editorial covering some interesting aspects of the topic.
    Keywords: grain refinement ; high strength and toughness ; {10–12} twin ; Mg-Gd-Y alloy ; multidirectional impact forging ; Mg-Zn-Mn-Ca ; Ca2Mg6Zn3 phase ; corrosion behaviors ; SKPFM ; boride ; MgB2 ; mechanical alloying ; ignition ; combustion ; flame temperature ; magnesium alloy ; biocompatibility ; surface coating modification ; corrosion resistance ; implantable bio-metal materials ; filler material ; welding ; scandium ; microstructure modification ; mechanical properties ; microstructure ; texture ; stretch formability ; high temperature cross-rolling ; annealing ; wire arc additive manufacturing ; cold metal transfer ; Al-Mg alloys ; orthogonal experiment ; Mg-Bi-Ca alloy ; hot deformation ; constitutive model ; dynamic recrystallization kinetics ; Mg alloy ; twinning ; random orientation ; compression ; room temperature ; backward extrusion ; tensile strength ; failure mechanism ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 6
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Metalliferous minerals play a central role in the global economy. They will continue to provide the raw materials we need for industrial processes. Significant challenges will likely emerge if the climate-driven green and low-carbon development transition of metalliferous mineral exploitation is not managed responsibly and sustainably. Green low-carbon technology is vital to promote the development of metalliferous mineral resources shifting from extensive and destructive mining to clean and energy-saving mining in future decades. Global mining scientists and engineers have conducted a lot of research in related fields, such as green mining, ecological mining, energy-saving mining, and mining solid waste recycling, and have achieved a great deal of innovative progress and achievements. This Special Issue intends to collect the latest developments in the green low-carbon mining field, written by well-known researchers who have contributed to the innovation of new technologies, process optimization methods, or energy-saving techniques in metalliferous minerals development.
    Keywords: metallurgical slag-based binders ; solidification/stabilisation ; As(III) ; As(V) ; calcium hydroxide ; sublevel caving ; numerical simulation ; physical model ; structural parameter ; green mining ; limestone ; high temperature ; confining pressure ; SHPB ; constitutive model ; open-pit mine ; PLAXIS 3D ; dynamic load ; safety factor ; acceleration ; particle sedimentation ; filling mining ; degree of influence ; pipeline transportation ; solid waste utilization ; tailings ; reclamation risk ; hazard identification ; complex network ; hazard management ; digital mine ; mine short-term production planning ; haulage equipment dispatch plan ; ABCA ; NSGA ; settlement velocity measurement ; K-means ; tailings backfill ; unsupervised learning ; cemented paste backfill ; ESEM ; picture processing ; floc networks ; pumping agent ; fractal dimension ; backfill slurry ; strength of cemented backfill ; inhomogeneity of cemented backfill ; cemented tailings backfill ; copper ; zinc ; recovery ; sulfide concentrate ; artificial microbial community ; granular backfill ; bearing characteristics ; numerical model ; particle size ; surface subsidence ; blasting dust movement ; dust concentration ; particle size distribution ; blasting dust reduction ; backfill ; metal mine ; log-sigmoid ; tailings pond ; regional distribution ; dam break ; accident statistics ; causation analysis ; backfilling ; increasing resistance and reducing pressure ; computational fluid dynamics ; spiral pipe ; stowing gradient ; coal-based solid waste ; orthogonal experiment ; strength development ; regression analysis ; engineering performance ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTU Mining technology and engineering
    Language: English
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  • 8
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 9
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Elastomer materials are characterized by their high elongation and (entropy) elasticity, which makes them indispensable for widespread applications in various engineering and medical areas as well as consumer goods. This book focuses on the state-of-the-art of elastomers covering all aspects from their properties to applications. The development and testing of advanced elastomers is of particular interest. Attention is given to various aspects of elastomers, such as ever-increasing environmental concepts dealing with recyclability and reusability, incorporation of functional groups or additives to obtain novel functionality or bioelastomers, analytical description of mechanisms and structure relations of the fracture behavior of elastomers, and their external stimuli-responsive character. The scope of the book encompasses contributions at the frontier of science in polymer network synthesis, experimental and theoretical physics of polymer networks, and new structures and functionalities incorporated into elastomers leading to enhanced properties of crosslinked elastomeric materials, among others.
    Keywords: magnetorheological elastomer ; filler ; hetero-aggregation ; nanosized Ni-Mg cobalt ferrites ; electrical resistance ; resistivity ; rheological properties ; elastomers ; in-situ silica ; friction ; abrasion ; tear fatigue test ; buffing dust collagen (BDC) ; styrene–butadiene rubber (SBR) ; polymer composites ; biodegradation ; bio-oil ; bio-based plasticizer ; eco-friendly plasticizer ; acrylonitrile-butadiene rubber ; NBR ; mechanical testing ; thermo-oxidative aging ; vulcanized rubber ; rubber compounds ; carbon black ; vibration damping ; viscoelasticity ; magnetorheological ; elastomer ; magnetic particle ; viscoelastic ; rheological ; smart materials ; coating ; particle coating ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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