ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles  (57)
  • Data
  • Photodynamic therapy  (57)
  • Technology  (57)
  • 1
    Electronic Resource
    Electronic Resource
    A comparison of gold-vapour and dye lasers for photodynamic therapy (1986)
    Springer
    Lasers in medical science 1 (1986), S. 117-120 
    Details
    ISSN: 1435-604X
    Keywords: Gold-vapour laser ; Argon-pumped dye laser ; Photodynamic therapy ; Cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract This paper compares the relative merits of the continuous wave argon-pumped dye laser and the pulsed gold-vapour laser as used clinically for photodynamic therapy. At comparable power and energy outputs, the biological effect of the two appears to be the same. However, for 1 W output (a suitable level for clinical use), the gold laser is simpler and easier to install and run, although it requires a larger diameter fibre for light delivery (0.6 mm v. 0.2 mm). The wavelength of the dye laser is tunable, whereas that of the gold is not, although the gold laser can be easily converted to a copper-vapour laser which can pump a tunable dye laser.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02038960
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Role of photodynamic therapy in the management of early cancers of the upper aerodigestive tract (1986)
    Springer
    Lasers in medical science 1 (1986), S. 217-220 
    Details
    ISSN: 1435-604X
    Keywords: Upper respiratory tract cancer ; Oronasopharyngeal cancer ; Photodynamic therapy ; Argon pumped dye laser ; Gold-vapour laser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Photodynamic therapy has been effective in the management of cancers arising in multiple sites, particularly skin, bronchi and bladder. In head and neck cancer, however, its use has been confined to the palliation of advanced lesions that have proved refractory to conventional therapy. While this use is unquestionably valid, the true therapeutic value of photodynamic therapy appears to be in managing early mucosal cancers of the upper aerodigestive tract. These include early superficial cancers and ‘condemned mucosa’. At the University of Cincinnati, photodynamic therapy has been used on a variety of such early cancers where, for a variety of reasons, conventional therapy was not possible, and with most encouraging results. The first 20 cases are reported here, to highlight the technical aspects encountered in management, together with the pitfalls and problems. This experience has led to the development of a multi-institutional study to compare the safety and efficacy of photodynamic therapy with those of carbon dioxide laser excision of superficial carcinoma of the oral cavity and oropharynx.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02040242
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Photodynamic therapy in the management of malignant gliomas: a review (1986)
    Springer
    Lasers in medical science 1 (1986), S. 163-174 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Malignant glioma ; Laser ; Haematoporphyrin derivative ; Photosensitizer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Interest in photodynamic therapy in the treatment of malignant gliomas began in the 1950s. Following the publication of papers showing that haematoporphyrin was excluded from the intact blood-brain barrier and that glioma cells grown in culture and subcutaneously could be killed by a combination of light and haematoporphyrin, a number of clinical trials was started, none of which has shown any measurable improvement in patient survival. The reason for this may relate to a lack of understanding of the mechanisms of photodynamic therapy and a lack of the scientific data needed to optimize photodynamic selectivity. This review discusses the potential role of photodynamic therapy in glioma treatment, and reviews the current clinical and experimental work in the field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02040233
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Photodynamic therapy and γ-irradiation of tumours: Effect of tumour-cell reoxygenation (1986)
    Springer
    Lasers in medical science 1 (1986), S. 193-195 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; γ-Irradiation ; Hypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The presence of adequate oxygen appears to be essential for photodynamic therapy (PDT) of tumours (1, 2). We used the mouse sarcoma 180 tumour model to investigate how the reoxygenation of the tumour cell population after a single exposure to γ-irradiation influenced the effect of photodynamic therapy. The combination of γ-irradiation with PDT leads to a significant enhancement of the therapeutic effect. The best effect is observed when the γ-irradiation precedes the PDT by 24 h, at which time reoxygenation of the tumour is greatest. Also, there is some enhancement of the effect when PDT is given before γ-irradiation, although the mechanism of this is not yet clear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02040237
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Development of an alternative light source to lasers for photodynamic therapy: 2. Comparative in vivo tumour response characteristics (1995)
    Springer
    Lasers in medical science 10 (1995), S. 121-126 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Haematoporphyrin derivative ; In vivo ; Laser ; Light source ; Murine tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The performance of a low cost, table-top/portable light source was tested against an argon ion pumped dye laser for in vivo photodynamic therapy (PDT). The prototype delivers up to 1 W via a 4 mm flexible lightguide within a 30 nm bandwidth centred at any wavelength from 300 nm to 1200 nm at fluence rates of up to 8 W cm−2. An in situ bioassay using regrowth delay of tumour T50/80 was used to quantify the relative efficacy of the prototype with a laser. The tumours were sensitized with haematoporphyrin derivative (HpD) and externally irradiated. There was no significant difference in the response of the tumour to treatment between the two light sources (p = 0.69). Mean growth delays ranged from 2 days (light dose 10 J cm−2) to 20 days (light dose 100 J cm−2). The estimate for the difference in means (laser minus prototype growth delay) was only 0.66 days and was not statistically significant. This in vivo study demonstrates that the prototype is equivalent to a laser in PDT effect. The device has low capital/running cost, is simple to use and is one of the most powerful, spectrally efficient non-laser PDT sources available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150849
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Construction, quality assurance and calibration of spherical isotropic fibre optic light diffusers (1995)
    Springer
    Lasers in medical science 10 (1995), S. 137-147 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Isotropic fibre optic light diffusers ; Construction of diffusers ; Quality assurance of diffusers ; Calibration of diffusers ; Goniometer ; Integrating sphere
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Spherical isotropic fibre optic light diffusers are used in photodynamic therapy either as a light source or as a light detector. The construction of light diffusers using different materials is described, viz. an optical method involving local polymerization of a dental fissure sealant, which is referred to as the Henderson method, and a second method using plastic or ceramic pre-fabricated spheres. Quality tests necessary for reliable clinical use are presented for the mechanical strength, output power and isotropy. The maximum pull-off force and blow-off output power for the different kinds of diffusers were determined. The calibration procedures are given for measurement of the output power and wavelength of the light emitted by a diffuser and for measurement of the fluence rate by a light-detecting diffuser, using a compact integrating sphere device. With all types of diffusers described, an isotropy can be obtained of better than ± 20% measured over a 320° angle for spheres as small as ≈ 1 mm. Larger ceramic diffusers are particularly suitable for delivering high output powers. A 3-mm-diameter ceramic diffuser mounted on a 600-μm-core fibre can emit up to ≈ 5 W of continuous wave (CW) visible light in air. Diffusers used for light detection can measure the light fluence rate in tissue with ≈15% accuracy or better if calibration factors are determined for each individual probe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150852
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Time-resolved confocal fluorescence microscopy of porphyrins for phototherapy (1996)
    Springer
    Lasers in medical science 11 (1996), S. 237-246 
    Details
    ISSN: 1435-604X
    Keywords: Fluorescence ; Time-resolved confocal microscopy ; Porphyrins ; Fluorescence polarization ; Photodynamic therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The application of a novel time-resolved confocal fluorescence microspectrometer to studies of the distribution and speciation of porphyrin photosensitizers in rat C6 cerebral glioma cells is described. The instrument combines a mode-locked argon ion laser excitation source with time-correlated single photon counting fluorescence detection and has sub-micron spatial and sub-nanosecond temporal resolution. The porphyrins studied were haematoporphyrin derivative (HpD), haematoporphyrin IX (HP), porphyrinc (Pc) and the tetrakiscarborane carboxylate ester of 2,4-(α,β-dihydroxyethyl) deuteroporphyrin IX (BOPP). From the heterogeneous emission observed in vitro, assignments and spatial location of various porphyrin species are proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02134914
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Photodynamic therapy in gynaecological cancer (1989)
    Springer
    Lasers in medical science 4 (1989), S. 155-158 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Gynaecological oncology ; Lasertherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Tumour recurrences in the gynaecological field after conventional therapy are a big problem because there is little choice for other therapies without inflicting further damage. Photodynamic therapy (PDT) is indicated because it is selective and without side-effects in flat or small recurrences. We treated 15 patients with vaginal and vault recurrences of cervix carcinoma, adenocarcinoma in the corpus uteri and rectum. The PDT was performed after 24–48 h with Hp, 5 mg/kg body weight, injection, and an argon-dye laser for 13 cases, tungsten and xenon lamps in 2 cases. All patients were previously treated with conventional therapy (i.e. surgery, radiotherapy, chemotherapy). Doses ranged from 60 to 500 J cm−2. The results were: 8 complete local responses, 6 partial responses, 1 no change. Four patients died because of distant metastases or progression. One partial response was treated with brachytherapy and is now disease free. All the other patients are still living. In all cases we have seen no side-effects from PDT. The patients were sheltered from the sunlight for 20–30 days after therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032429
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Misonidazole combined with photodynamic therapy of rat 9L gliosarcoma tumours (1989)
    Springer
    Lasers in medical science 4 (1989), S. 79-84 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Haematoporphyrin derivative ; Misonidazole ; Radiosensitizers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Fifty-six Fischer 344 rats bearing subcutaneous 9L-gliosarcoma tumours were studied to determine if Misonidazole (MISO), combined with photodynamic therapy (PDT), would be more effective than PDT alone. PDT, like conventional radiation, is potentiated by oxygen, and if there are areas of hypoxic cells within the tumour it is possible that the addition of the radiosensitizing drug should make the treatment more effective. Thirty-nine rats were divided into eight groups as controls. Seventeen rats were divided into three groups and received MISO combined with PDT, five rats were exposed to a laser dose of (nm = 630) 300 J at 300 mW, seven rats to a laser dose of 600 J at 600 mW and five rats to a laser dose of 2160 J at 600 mW. The tumours were approximately 1 cm3 when treated. Animals treated with either PDT at 300 J or 600 J failed to show any effect on growth of the tumour. At 2160 J a definite delay in growth was observed but addition of MISO did not potentiate this effect. The results indicate this combined therapy did not slow the growth rate of the tumours in this model. The implication of these results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032602
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    The spectral dependence of the optical properties of human brain (1989)
    Springer
    Lasers in medical science 4 (1989), S. 221-227 
    Details
    ISSN: 1435-604X
    Keywords: Optical properties ; Photodynamic therapy ; Glioma ; Brain tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The in vitro optical properties of slices of human brain tissue were measured. The experiments were performed with an integrating sphere and covered the wavelength range from 400 to 1100 nm. Both normal brain tissue (white and grey matter) and tumour tissue (a malignant glioma and a melanotic melanoma) were investigated. From the experimental data the Kubelka-Munk absorption and scattering coefficients were determined. From these data we calculated the transport absorption and scattering coefficients by using the diffusion approximation. Blood and water appeared to be the dominant chromophores. In the wavelength range mentioned, the absorption coefficients varied over more than two orders of magnitude. The scattering coefficients increased slowly towards the shorter wavelengths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032451
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...