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  • Chemistry  (43,309)
  • METEOROLOGY AND CLIMATOLOGY  (1,773)
  • 1980-1984  (35,488)
  • 1930-1934
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Keywords
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Years
Year
  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
    Print ISSN: 0036-8075
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Joint Airport Weather Studies (AWS) project (1983)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The joint airport weather studies (JAWS) project is discussed. The major objectives of the JAWS Project are a fundamental description of the phenomenon, a determination of the hazard potential and a definition of a protection and warning system, all of which are relative to low level wind shear. Aspects of the low level wind shear phenomenon. The principal focus, however, is the microburst. The microburst is fundamentally a rather simple atmospheric flow. It is a downdraft that, upon approaching the surface, spreads out horizontally, producing a diverging radial flow in all directions. For any direction that an aircraft flies through the microburst, it will first encounter increasing head winds; then the remnants of the downdraft; and then, increasing tail wind.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 85-95
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    Lightning strike experience in the NASA F-106B storm hazards program (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A heavily instrumented F-106B aircraft was flown in thunderstorms to gather data for characterizing lightning at aircraft operating altitudes. Conventional weather finding techniques are supplemented with UHF lightning mapping radar to select the most active storm cells and the most likely altitude for obtaining direct lightning strikes to the airplane. One hundred seventy-six strikes were obtained in a 3 year period, mostly at an altitude of above 25,000 feet.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 63-65
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    Wind shear and vortex wake research in UK, 1982 (1983)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A wind shear and vortex wake and their impact on aircraft were investigated. The systems and advice to help pilots, and rational scientific methods to assist in advising certification authorities and those interested in improving flight safety were developed. Wind Shear and Vortex Wakes are related, they are both invisible enemies of aircraft in the form of large disturbances in the atmosphere, both cause major accidents. Problems of building wakes at airports are is considered. Research on wind shear was initiated by the American FAA following the Boston, New York and Denver accidents to civil airliners. This resulted in: useful advice to pilots about wind shear; better attempts by the meteorologists at forecasting wind shear conditions; and useful ideas for wind shear measurement and warning systems. Three major research tasks are outstanding: (1) Worldwide measurements to give reliable estimates of probability and details of the forms of large wind shears; (2) Developments of real time wind shear measuring systems for ground or airborne use; and (3) Establishing relationships between measured wind shear and the potential hazard to an aircraft, or class of aircraft.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 66-83
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    Marked surface inversions and wind shear: A safety risk for departing aircraft (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Marked surface inversions occur most frequently in dry continental climates, where low atmospheric humidity allows heat transfer by long wave thermal radiation. In the northern latitudes, surface inversions reach their maximum intensity during the winter, when the incoming Sun's radiation is negligible and radiative cooling is dominant during the long nights. During winter, air mass boundaries are sharp, which causes formation of marked surface inversions. The existence of these inversions and sharp boundaries increase the risk of wind shear. The information should refer to marked inversions exceeding a temperature difference of 10 deg C up to 1000 feet. The need to determine the temperature range over which he information is operationally needed and the magnitude of the inversion required before a notification to pilots prior to departure is warranted are outlined.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 61-62
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  • 39
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    A cursory glance at results from NASA's B-57B gust gradient program (1983)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The Gust Gradient Program is a data intensive effort involving tripple Doppler radar, a surface weather station mesonet and other aircraft. The Joint Airport Weather Studies was utilized to gain additional data. The data were used to fill in the gap in turbulence modeling.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 38-42
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  • 40
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    GEM: Statistical weather forecasting procedure (1983)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The objective of the Generalized Exponential Markov (GEM) Program was to develop a weather forecast guidance system that would: predict between 0 to 6 hours all elements in the airways observations; respond instantly to the latest observed conditions of the surface weather; process these observations at local sites on minicomputing equipment; exceed the accuracy of current persistence predictions at the shortest prediction of one hour and beyond; exceed the accuracy of current forecast model output statistics inside eight hours; and be capable of making predictions at one location for all locations where weather information is available.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 42-44
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    Department of Defense meteorological and environmental inputs to aviation systems (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Recommendations based on need, cost, and achievement of flight safety are offered, and the re-evaluation of weather parameters needed for safe landing operations that lead to reliable and consistent automated observation capabilities are considered.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 19-20
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  • 42
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    Aviation weather services (1983)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The primary responsibilities of the National Weather Service (NWS) are to: provide warnings of severe weather and flooding for the protection of life and property; provide public forecasts for land and adjacent ocean areas for planning and operation; and provide weather support for: production of food and fiber; management of water resources; production, distribution and use of energy; and efficient and safe air operations.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 14-16
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    Federal Aviation Administration weather program to improve aviation safety (1983)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The implementation of the National Airspace System (NAS) will improve safety services to aviation. These services include collision avoidance, improved landing systems and better weather data acquisition and dissemination. The program to improve the quality of weather information includes the following: Radar Remote Weather Display System; Flight Service Automation System; Automatic Weather Observation System; Center Weather Processor, and Next Generation Weather Radar Development.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 21-25
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    On the effect of temporal sampling on the observation of mean rainfall (1981)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Rainfall characteristics using data from dense recording raingage networks is reviewed. Data from such networks have quantified temporal and spatial rainfall distributions, and have supplied specialized information about local and orographic effects. The natural variability, temporally and spatially, for annual, seasonal, monthly, and individual events is treated. Especially important are the spatial variations of precipitation as a function of synoptic type, precipitation type, amount, and duration. Results from dense raingage networks in Illinois, and some data from other climatic regions is also treated.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Precipitation Meas. from Space:; 8 p
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    Prospects for measuring phytoplankton bloom extent and patchiness using remotely sensed color images: An example (1981)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: A 10 channel scanning radiometer, built as a prototype for the coastal zone color scanner on the Nimbus 7 satellite, was flown on a high altitude aircraft during a Gymnodium breve bloom along the west coast of Florida. The remotely measured ocean color imagery shows what is probably the patchy structure of a G. breve bloom extending over a 60 km by 100 km area. This conclusion is based on visual inspection of bathymetry to infer bottom reflection trends and on a single growth truth measurement of B G. breve obtained the previous day. The image shows coherent blooms which extend scales up to 60 km in length.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints 1978 - 1979, Vol. 2; p 680-685
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    Application of a snowmelt-runoff model using LANDSAT data (1980)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: The snowmelt-runoff model developed for two small central European watersheds simulate daily streamflow on the 228 sq km Dinwoody Creek basin in Wyoming, using snowcover extent for LANDSAT and conventionally measured temperature and precipitation. For the six-month snowmelt seasons of 1976 and 1974, the simulated seasonal runoff volumes were within 5 and 1%, respectively, of the measured runoff. Also the daily fluctuations of discharge were simulated to a high degree by the model. Thus far the limiting basin size for applying the model has not been reached, and improvements can be expected if the hydrometeorological data can be obtained from a station inside the basin. LANDSAT provides an efficient way to obtain the critical snowcover input parameter required by the model.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints 1978 - 1979, Vol. 2; p 745-760
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  • 47
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    Arctic Sea ice decay simulated for a CO2-induced temperature rise (1981)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: A large scale numerical time-dependent model of sea ice that takes into account the heat fluxes in and out of the ice, the seasonal occurrence of snow, and ice motions was used in an experiment to determine the response of the Arctic Ocean ice pack to a warming of the atmosphere. The degree of warming specified is that expected for a doubling of atmospheric carbon dioxide with its associated greenhouse effect, a condition that could occur before the middle of the next century. The results of three 5-year simulations with a warmer atmosphere and varied boundary conditions were: (1) that in the face of a 5 K surface atmospheric temperature increase the ice pack disappeared completely in August and September but reformed in the central Arctic Ocean in mid fall; (2) that the simulations were moderately dependence on assumptions concerning cloud cover; and (3) that even when atmospheric temperature increases of 6-9 K were combined with an order-of-magnitude increase in the upward heat flux from the ocean, the ice still appeared in winter. It should be noted that a year-round ice-free Arctic Ocean has apparently not existed for a million years or more.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints 1978 - 1979, Vol. 2; p 687-700
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    The 1977 tundra fire at Kokolik River, Alaska (1981)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: During the summer of 1977, fire totaled 44 sq km of tundra vegetation according to measurements using LANDSAT imagery. Based on the experience gained from analysis of this fire using ground observations, satellite imagery, and topographic maps, it appears that natural drainages form effective fire breaks on the subdued relief of the Arctic coastal plain and northern foothills. It is confirmed that the intensity of the fire is related to vegetation type and to the moisture content of the organic rich soils.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints 1978 - 1979, Vol. 2; p 660-670
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    Development of the operational program for satellite meteorology (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: The geostationary and polar satellites comprising the current operational system are discussed. The data acquisition capabilities of both satellite types and their complementary functions are reviewed. The advanced very high resolution radiometer on the TIROS N satellites is particularly addressed along with the imaging and atmospheric sounding instrumentation aboard the GOES satellites. The dissemination of the satellite data to the prospective users is also discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 34-40
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  • 50
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    The utilization of spaceborne microwave radiometers for monitoring snowpack properties (1980)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Snow accumulation and depletion at specific locations can be monitored from space by observing related variations in microwave brightness temperatures. Using vertically and horizontally polarized brightness temperatures from the Nimbus 6 electrically scanning microwave radiometer, a discriminant function can be used to separate snow from no snow areas and map snowcovered area on a continental basis. For dry snow conditions on the Canadian high plains, significant relationships between snow depth or water equivalent and microwave brightness temperature were developed which could permit remote determination of these snow properties after acquisition of a wider range of data. The presence of melt water in the snowpack causes a marked increase in brightness temperature which can be used to predict snowpack priming and timing of runoff. As the resolutions of satellite microwave sensors improve the application of these results to snow hydrology problems should increase.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints 1978 - 1979, Vol. 2; p 745-760
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    Seasonal and daily snowmelt runoff estimates utilizing satellite data (1980)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Methods using snowcovered area to update seasonal forecasts as snowmelt progresses are also being used in quasi-operational situations. The input of snowcovered area to snowmelt models for short term perdictions was attempted in two ways; namely, the modification of existing hydrologic models and/or the use of models that were specifically designed to use snowcovered area. A daily snowmelt runoff model was used with LANDSAT data to simulate discharge on remote basins in the Wind River Mountains of Wyoming. Daily predicted and actual flows compare closely, and, summarized over the entire snowmelt season (April 1 - September 30), the average difference is only three percent. The model and snowcovered area data are currently being tested on additional watersheds to determine the method's transferability.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci. Collected Reprints 1978 - 1979, Vol. 2; p 742
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    The 1977 tundra fire in the Kokolik River area of Alaska (1981)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Presumably caused by lightning, a large fire occurred due east of Point Lay several kilometers southwest of the Kokolik River, the farthest north a fire was ever fought by Bureau of Land Management personnel in Alaska. The progress and area extent of the fire were determined by analysis of LANDSAT MSS band 5 and 7 imagery. Low altitude observations from helicopter showed the fire burned a range of vegetation and relief types which included low polygonized and upland tussock tundras. The burned area appeared wetter on the surface than the unburned area, due to a lack of moisture absorbing organic matter and the possible release of moisture from the deeper thawed zone. Suggestions for future investigations of the effects of fire on tundra and permafrost terrains are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints 1978 - 1979, Vol. 2; p 671-675
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    Early program development and implementation (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: Programs for the development and operation of meteorological satellites from the TIROS 1 satellite and the establishment of NASA through the 1960's are described. The technical problems confronted in the development of the early satellite systems are discussed in addition to issues in international involvement and program support. The TIROS and Nimbus series satellites are primarily addressed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 5-33
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    The climatic effect of explosive volcanic activity: Analysis of the historical data (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: By using the most complete available records of direct beam radiation and volcanic eruptions, an historical analysis of the role of the latter in modulating the former was made. A very simple fallout and dispersion model was applied to the historical chronology of explosive eruptions. The resulting time series explains about 77 percent of the radiation variance, as well as suggests that tropical and subpolar eruptions are more important than mid-latitude eruptions in their impact on the stratospheric aerosol optical depth. The simpler climatic models indicate that past hemispheric temperature can be stimulated very well with volcanic and CO2 inputs and suggest that climate forecasting will also require volcano forecasting. There is some evidence that this is possible some years in advance.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 191-202
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    Distribution of Mount St. Helens dust inferred from satellites and meteorological data (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: Visible and infrared pictures from two Geostationary Operational Environmental Satellite Systems satellites, in circular orbits at about 19,000 nautical miles, are available continuously at approximately 30 minute intervals. Still pictures and film loops from this system vividly depict the events associated with the May 18, 1980 eruption of Mount St. Helens. The initial explosion, shock wave, and visible horizontal dust distribution during the following week are readily apparent. Meteorological wind and height fields permit the inference of the vertical distribution of volcanic dust as well as explain the atmospheric behavior which caused the visible and nonvisible dust distribution.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 131-140
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    Comments on satellite meteorology from geostationary satellites (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: Examples of the use of geostationary satellites in meteorology are given. Studies of the rate of change of cumulus clouds and cloud systems and wind parameter determination from cloud motions are reviewed. Computer processed imagery products are also discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 72-83
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    Military applications evolution and future (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: The Defense Meteorological Satellite Program is described with particular emphasis on the military applications of METSAT data. Satellite operational support, data processing and image quality requirements are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 41-47
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    Early satellite program developments (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: A historical overview of the pioneer projects for the development of meteorological satellites is given. In addition, the parallel development of the responsible space agencies and panels is addressed. The Vanguard 2 satellite, the first Earth radiation experiment, and the vidicon equipped TIROS-1 satellite are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 1-4
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    Problems in the climatology of the 1980 Mount St. Helens eruptions (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: A brief review of the effects of climate and weather on the 1980 Mount St. Helens eruptions and the subsequent dispersion of ash and gases and the reciprocal influences of the eruptions on climate and climatology is presented. The effects of mesoscale destruction of snow fields and vegetation, a revised mountain profile, and ash deposits are addressed along with impacts on hemispheric climate and disruption of normal climatological observations, in the areas directly affected by the explosions and ashfall. Environmental and economic consequences are also considered.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 203-209
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    Lightning research: A user's lament (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: As a user of devices and procedures for lightning protection, the author is asking the lightning research community for cookbook recipes to help him solve his problems. He is lamenting that realistic devices are scarce and that his mission does not allow him the time nor the wherewithal to bridge the gap between research and applications. A few case histories are presented. In return for their help he is offering researchers a key to lightning technology--the use of the Eastern Test Range and its extensive resources as a proving ground for their experiment in the lightning capital of the United States. A current example is given--a joint lightning characterization project to take place there. Typical resources are listed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Intern. Aerospace and Ground Conf. on Lightning and Static Elec.; 6 p
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    A study of the geographic coverage properties of a satellite borne Doppler lidar wind velocity measuring system (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Geographic coverage frequency and geographic shot density for a satellite borne Doppler lidar wind velocity measuring system are measured. The equations of motion of the light path on the ground were derived and a computer program devised to compute shot density and coverage frequency by latitude-longitude sections. The equations for the coverage boundaries were derived and a computer program developed to plot these boundaries, thus making it possible, after an application of a map coloring algorithm, to actually see the areas of multiple coverage. A theoretical cross-swath shot density function that gives close approximations in certain cases was also derived. This information should aid in the design of an efficient data-processing system for the Doppler lidar.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 26 p
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    The Joint Airport Weather Studies Project (1981)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A block diagram of the joint airport weather studies program is presented. Background leading to the development of the program is reviewed. Basic studies, aircraft performance, and detection and warning techniques used to develop fine scale structure of thunderstorm dynamics and kinematics in the vicinity of a major airport; effect of thunderstorm low level wind shear on aircraft performance; and development of real time testing of flow level wind shear detection and warning techniques and displays are described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 5th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 91-95
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    Prototype Regional Observation and Forecast System (PROFS) (1981)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The prototype regional observation and forecast system (PROFS) outputs are demonstrated, functional design specifications to be used to procure and implement operational systems are outlined. Advanced candidate technologies are evaluated as an integral part of the process that leads to these outputs. Evaluation insures that future weather service systems will contain the optimum mix of technologies to be most cost effective in reducing the annual losses and deaths that are directly attributed to severe weather.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 5th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 81-85
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  • 64
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    Progress on low altitude cloud icing research (1981)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The icing environment at altitudes below 10,000 feet were studied. The following questions are asked, are: (1) existing aircraft certification criteria applicable; (2) too stringent on icing for helos; (3) based on accurate data; (4) appropriate for low (10,000 ft) altitudes? The research plan is outlined: review historical icing data, obtain new measurements, collect modern icing data from other groups, and recommend LWC, OAT, and MVD criteria for helicopters. Estimated accuracies and known sources of error are included. It is concluded that the net effect of possible sources of error of both signs is uncertain.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 5th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 59-63
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  • 65
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    The program of the Techniques Development Laboratory in aviation weather forecasting (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Some operational and experimental products developed for aviation weather forecasting are briefly described. Experimental products include surface dew point, obstructions to vision, boundary layer model, computer-worded terminal forecasts, terminal alerting procedure, generalized equivalent Markov, and radar forecasts (0-2 hours).
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 209-212
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  • 66
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    Doctor Fujita's microburst analysis at Chicago (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Doppler radar measurements of an intense wind shear occurance are discussed. The data suggest the presence of an incredibly strong low level jet outflow component of the microburst event, reaching 60 knots only 50 meters above the surface. Evidence also suggests that microbursts more typically occur in very weak thunderstorms that have hardly reached thunderstorm stage.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 201-202
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  • 67
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    The microburst: Common factor in recent aircraft accidents (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The phenomenology of one class of strong thunderstorm downdrafts, microbursts, is described. Several aircraft accidents are analyzed in which a microburst was involved and a concept for an early warning wind shear sensor is presented.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 186-200
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  • 68
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    Clear air turbulence forecasting techniques (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: A method to improve clear air turbulence (CAT) forecasting by more effectively using the currently operational rawinsonde (RW) system is discussed. The method is called the Diagnostic Richardson Number Tendency (DRT) technique. The technique does not attempt to use the RW as a direct detector of the turbulent motion or even of the CAT mechanism structure but rather senses the synoptic scale centers of action which provide the energy to the CAT mechanism at the mesoscale level. The DRT algorithm is deterministic rather than statistical in nature, using the hydrodynamic equations (equations of motion) relevant to the synoptic scale. However, interpretation, by necessity, is probabilistic. What is most important with respect to its operational implementation is that this method uses the same input data as currently used by the operational National Meteorological Center prognostic models.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 203-208
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  • 69
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    The 1979 clear air turbulence flight test program (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: A clear air turbulence (CAT) flight test to evaluate and test four different sensors in the detection and measuring of CAT and other meteorological targets that relate to turbulence is discussed. The primary types of CAT investigated were mountain wave CAT, jetstream CAT, CAT in cirrus clouds, and CAT in frontal wind shears, troughs, and ridges. The sensors included the CO2 pulsed Doppler lidar and three radiometers. One of the radiometers, at a frequency of 55.5 GHz, looked at atmospheric temperature structure. Another, at a frequency of 180.1 GHz, looked at atmospheric water vapor and investigated the feasibility of measuring at the microwave frequency the turbulence features seen in the infrared (IR) frequencies. An IR radiometer at 27 to 33 microns was the fourth sensor. This last device and the temperature structure radiometer worked well at all flight levels.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 171-179
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  • 70
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    Very short range forecasts of visibility and ceiling (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The development of methods for the short range forecasting of visibility and ceiling conditions is discussed. Short range forecasts of one hour or less (5 or 30 minutes), immediately after a series of local observations can be expected to be more accurate and reliable than any forecast of more than one hour. These forecasts can be accomplished by the operational implementation of fully automated aviation observation systems and the utilization of statistical techniques such as the Generalized Equivalent Markov model.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 180-185
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  • 71
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    Measuring weather for aviation safety in the 1980's (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Requirements for an improved aviation weather system are defined and specifically include the need for (1) weather observations at all airports with instrument approaches, (2) more accurate and timely radar detection of weather elements hazardous to aviation, and (3) better methods of timely distribution of both pilot reports and ground weather data. The development of the discrete address beacon system data link, Doppler weather radar network, and various information processing techniques are described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 162-167
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  • 72
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    Observing lightning from ground-based and airborne stations (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The operational designs and performance capabilities of ground-based and airborne lightning detection systems are reviewed. The airborne Stormscope system is described and compared with onboard radar and the lightning detection and ranging system (LDAR). Two examples of difference-in-time-of-arrival systems for detecting spherics from discharges in electrified clouds are described: (1) The LDAR system and (2) Taylor's lightning mapping system. Next, an interferometric system adapted to lightning location is discussed. Finally, systems that are based upon crossed-loop magnetic direction finding principles but which have been refined and improved to accurately locate lightning discharges to ground are reviewed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 130-139
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    Aeronautical concerns and National Aeronautics and Space Administration atmospheric electricity projects (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The phenomenology of lightning and lightning measurement techniques are briefly examined with a particular reference to aeronautics. Developments made in airborne and satellite detection methods are reported. NASA research efforts are outlined which cover topics including in-situ measurements, design factors and protection, remote optical and radio frequency measurements, and space vehicle design.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc.: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 140-160
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  • 74
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    Remote probing of wind and wind shears (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The ability of various types of remote probes to measure wind is discussed. Two important advantages over in-situ sensors are reported: (1) their ability to measure atmospheric parameters without disturbing the air flow; (2) their ability to scan through large volumes of the atmosphere with relative ease. Direct measurement sensors such as anemometers and wind vanes are categorized into two groups; active and passive. Acoustic radar, microwave radar, and lidar are included in the first group and the latter group is typified by the infrared radiometers.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 109-124
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  • 75
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    Winds and wind shear in-situ sensors (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The problem of development of instrumentation for providing wind speed and direction information directly or indirectly to a pilot in the cockpit is considered. The pilots need for horizontal wind information at various stages of flight (i.e., at liftoff, in approach and departure corridors, and even in flight outside the terminal area) are emphasized.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 82-108
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  • 76
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    Clear air turbulence: Historical comments (1980)
    In:  CASI
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    Description: The basic reference material for gust design criteria are cited. The status of clear air turbulence meteorology (forecasting and detection) is discussed. The directions of further research technology is indicated.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc: Fourth Ann. Workshop on Meterol. and Environ. Inputs to Aviation Systems; p 71-81
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  • 77
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    Aircraft icing instrumentation: Unfilled needs (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: A list of icing instrumentation requirements are presented. Because of the Army's helicopter orientation, many of the suggestions are specific to rotary wing aircraft; however, some of the instrumentation are also suitable for general aviation aircraft.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 61-65
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  • 78
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    Icing instrumentation (1980)
    In:  CASI
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    Description: The types and usage categories of icing instrumentation are discussed. The state-of-the-art for the technology governing the use of icing instrumentation is reported with particular emphasis on ground based facilities for icing tests.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 49-60
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  • 79
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    Turbulence: From a pilot's viewpoint (1980)
    In:  CASI
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    Description: The measurement of atmospheric turbulence is discussed in terms of a pilots viewpoint. Two areas of measurement are considered: frequency and severity of turbulence. Suggestions are given for helping the pilot solve the turbulence problem.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 66-70
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  • 80
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    Federal Aviation Administration and National Weather Service Aviation Research and Development (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: An overview is given of the developmental status of aviation weather services. Particular attention is given to justifying the need for better, more reliable service. The accomplishments of several automatic weather stations are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 45-48
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  • 81
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    Aviation meteorology research and development: A status report (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The dynamic and rapid growth of technology in the area of aviation meteorology research and development are described with emphasis on the measurement of hazardous weather phenomena. Aspects of both onboard instrumentation and ground based facilities are evaluated in terms of their effectiveness of in avoiding hazards due to atmospheric electricity and lightning. Methods of alleviating terminal are hazards such as fog, low visibility and ceilings are also described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 40-44
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  • 82
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    Survey of Workshops on Meteorological and Environmental Inputs to Aviation Systems (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Various aspects of aviation meteorology are discussed with respect to their relative effects on aircraft terminal operations. Existing data on turbulence and wind shear from aircraft and towers are summarized. The significance of obtaining more real time wind and temperature information is emphasized. The application and testing of various radiometer devices are also described. Airborne methods to indicate wind differences at flight altitude and at touchdown are reported.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc: Fourth Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 23-39
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  • 83
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    First Scientific Working Group Meeting of Airborne Doppler Lidar Wind Velocity Measurement Program, appendix J (1980)
    In:  CASI
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    Description: Three projects are suggested which could be done using the Doppler lidar. The first is a cooperative effort at BAO, the purpose of which is to check out instrumentation and contribute to boundary layer investigations at BAO. The second concerns unintended weather modification. Its purpose is to detect mechanisms by which regions of industry and urbanization modify weather. The cirrus cloud study proposes to characterize cirrus clouds by their lidar signal and to compare lidar and visually observed characteristics.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center First Sci. Working Group Meeting of Airborne Doppler Lidar Wind Velocity Meas. Program; 5 p
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  • 84
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    Report of secondary flows, boundary layers, turbulence and wave team, report 1 (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: General criteria for a flight test option are that: (1) there be a good opportunity for comparison with other measurement techniques; (2) the flow to be measured is of considerable scientific or practical interest; and (3) the airborne laser Doppler system is well suited to measure the required quantities. The requirement for comparison, i.e., ground truth, is particularly important because this is the first year of operation for the system. It is necessary to demonstrate that the system does actually measure the winds and compare the results with other methods to provide a check on the system error analysis. The uniqueness of the laser Doppler system precludes any direct comparison, but point measurements from tower mounted wind sensors and two dimensional fields obtained from radars with substantially different sampling volumes are quite useful.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: First Sci. Working Group Meeting of Airborne Doppler Lidar Wind Velocity Meas. Program; 8 p
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  • 85
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    Cooperative convective precipitation experiment (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The experiment strives to improve understanding of the physics of convective precipitation. Major emphasis is placed on obtaining a good description of the whole convective precipitation system. A framework is presented within which single, significant, tractable problems are investigated.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center First Sci. Working Group Meeting of Airborne Doppler Lidar Wind Velocity Meas. Program; 25 p
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    Severe storms measurement system real time data processing and displays (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The objectives of the system are to provide the system operator with real time system performance check and to provide data recording of all SSMS data. Meteorologists are provided with real time indication of meteorological data measurements including aid for directing flight profiles in real time and aid for directing SSMS operations. A day-to-day feedback is provided to meteorologists, system operators, and flight crews for flight planning on subsequent flight tests days.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center First Sci. Working Group Meeting of Airborne Doppler Lidar Wind Velocity Meas. Program; 15 p
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    First Scientific Working Group Meeting of Airborne Doppler Lidar Wind Velocity Measurement Program, appendix C (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The problem is to operate on two scalar fields to produce a vector field, to produce user products from the vector field, and to establish reliability of results. Data problems encountered include sparse measurements, irregular distribution, varying quality, imperfect orthogonality, aliasing due to sampling volume, and measurements not simultaneous. Desired algorithm characteristics, solution elements, and characteristics of the model are listed. The seven simulation elements, eight algorithm steps and the required user inputs are given.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center First Sci. Working Group Meeting of Airborne Doppler Lidar Wind Velocity Meas. Program; 8 p
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  • 88
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    Report of convective phenomena team (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: A group meeting was assembled to focus on the planning of specific experiments, to establish some priorities, identify interested scientists who would like to participate, establish any special requirements, make recommendations on data processing, and to prepare flight plan outlines. Since the number of convective storms in the CCOPE (Cooperative Convective Precipitation Experiment) field experiment area are limited to only a few days during the operational time period the flight plans must be designed with a hierarchy of abort experiments so that the easily identified and lowest probability events should take priority until their quota is filled.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: First Sci. Working Group Meeting of Airborne Doppler Lidar Wind Velocity Meas. Program; 10 p
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  • 89
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    The MSFC Doppler lidar system, appendix B (1980)
    In:  CASI
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    Description: The development of pulsed and continuous wave Doppler lidars for atmospheric measurement is discussed. A description of how the lidar systems operate is presented. The scanning mode is also described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 40-42
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    Possible applications of MSFC Doppler lidar system, appendix C (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: An interpretation of the Doppler lidar return is presented. Possible applications of the system to severe storm research are discussed. The present project schedule of the Doppler lidar system is outlined.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 43-46
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    Wind field measurement in the nonprecipitous regions surrounding storms by an airborne pulsed Doppler lidar system, appendix A (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Coherent Doppler lidar appears to hold great promise in contributing to the basic store of knowledge concerning flow field characteristics in the nonprecipitous regions surrounding severe storms. The Doppler lidar, through its ability to measure clear air returns, augments the conventional Doppler radar system, which is most useful in the precipitous regions of the storm. A brief description of the Doppler lidar severe storm measurement system is provided along with the technique to be used in performing the flow field measurements. The application of the lidar is addressed, and the planned measurement program is outlined.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 31-39
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  • 92
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    Application of the Doppler lidar system to agricultural burning and air-sea interactions (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The Doppler lidar system is potentially a very powerful measurement system. Three areas concerning the system are discussed: (1) error analysis of the system to verify the results; (2) application of the system to agricultural burning in California central valley; and (3) oceanographic possibilities of the system.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 25
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    Measurement of phenomena associated with water clouds using Doppler lidar (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Doppler lidar measurements of phenomena associated with water clouds (such as aerosols) are discussed. The purpose of the measurements and details of executing the experiment are described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 20-24
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  • 94
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    Potential uses of the airborne Doppler lidar wind velocity measurement system (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Four aspects of the Doppler lidar are discussed: (1) error analysis of the system; (2) design of the first field program; (3) potential areas of application; and (4) verification of Doppler lidar data by independent measurements.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 16-17
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  • 95
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    Potential scientific research which will benefit from an airborne Doppler lidar measurement system (1980)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Areas of research which can be significantly aided by the Doppler lidar airborne system are described. The need for systematic development of the airborne Doppler lidar is discussed. The technology development associated with the systematic development of the system will have direct application to satellite systems for which the lidar also promises to be an effective instrument for atmospheric research.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 13-15
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    Potential applications of the Doppler lidar measurements (1980)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: The potential application of the Doppler lidar measurements to the determination of material (e.g., water vapor) and energy budgets, momentum transports, etc., in the environment at all stages and in the development of convective clouds are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 18-19
    Format: text
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  • 97
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    Airborne Doppler lidar wind measuring system: Application to atmospheric problems (1980)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: The ability to map velocities over a large area on one side of the aircraft flight path offers a number of opportunities to elucidate scientific questions related to atmospheric dynamics. Several types of experiments which are possible are described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Exploratory Meeting on Airborne Doppler Lidar Wind Velocity Meas.; p 11-12
    Format: text
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  • 98
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    Thunderstorm electric field modelling (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Calculation of eletric field vectors within and near an isolated thundercloud (which has a given volume charge distribution) is envisaged. The maximum field strength within the thundercloud is calculated. The effects of screening layers, both above and below the thundercloud may be investigated, as well time-dependent potential problem. The study can lead to a better understanding of the charge distributions in a thundercloud, which in turn may shed some light on the actual mechanism of charging of a thundercloud.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 10 p
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  • 99
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    Statistical Analysis of daily mean temperatures (1980)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Data of daily mean temperatures recorded at the Kennedy Center during the period of 1957-1977 were analyzed to forecast daily mean temperatures and their thirty-day moving averages for a period of ten to fifteen days in a given month. Since it is found that the standard deviation is linear in the mean, a logarithmic transformation of the data is used for finding an integrated moving average process IMA by the Box-Jenkins aproach. The first differences of the transformed data seem to fit a moving average model with parameter value 2, MA(2). The consideration of seasonality factor makes the fit worse.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: The 1981 NASA(ASEE Summer Fac. Fellowship Program; 13 p
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  • 100
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    Some experiments on the effect of remote sounding temperatures upon weather forecasting (1981)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: A time-continuous statistical method is presented for the four dimensional assimilation of remote sounding temperatures based on radiance measurements from polar orbiting satellites. This method is applied to DST 6 data from the NOAA 4 and Nimbus 6 satellites. The state of the atmosphere throughout the test period was determined using a varying amount of satellite data from the NOAA 4 satellite only, from Nimbus 6 only, and from both satellites together. The methods tested included different variations of the statistical method, as well as more traditional methods. It is concluded that satellite derived temperature data can have a modest, but statistically significant positive impact on numerical weather prediction in the two to three day range, and that this impact is highly sensitive to the quantity of data available and to the assimilation method used.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Goddard Lab. for Atmospheric Sci., Collected Reprints, 1978 - 1979, Vol. 1; p 175-199
    Format: text
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