Publication Date:
1978-09-29
Description:
Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. Approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of P. falciparum. All immunized monkeys survived the challenge. The substitution of Freund's complete adjuvant is an encouraging step toward the development of an effective and safe vaccine for human malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siddiqui, W A -- Taylor, D W -- Kan, S C -- Kramer, K -- Richmond-Crum, S M -- Kotani, S -- Shiba, T -- Kusumoto, S -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99814" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylmuramyl-Alanyl-Isoglutamine/*immunology
;
*Adjuvants, Immunologic
;
Animals
;
Glycopeptides/*immunology
;
Haplorhini
;
Liposomes
;
Malaria/*prevention & control
;
Plasmodium falciparum/*immunology
;
*Vaccination
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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