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  • Cell Line  (157)
  • American Association for the Advancement of Science (AAAS)  (157)
  • Annual Reviews
  • 1980-1984  (157)
  • 1930-1934
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (157)
  • Annual Reviews
Years
Year
  • 1
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    T-1 cells are HeLa and not of normal human kidney origin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson-Rees, W A -- Flandermeyer, R R -- Daniels, D W -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):719-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394535" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Chromosome Banding ; HLA Antigens/analysis ; HeLa Cells/*cytology/immunology ; Humans ; Karyotyping ; Kidney/*cytology/immunology ; Metaphase
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Estrogen and the growth of breast cancer: new evidence suggests indirect action (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafie, S M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):701-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/metabolism/*physiopathology ; Castration ; Cell Division/drug effects ; Cell Line ; Cytosol/metabolism ; Estradiol/metabolism/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Renin and angiotensin: the complete system within the neuroblastoma x glioma cell (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, M C -- Zimmerman, E A -- Slater, E E -- HL-21247/HL/NHLBI NIH HHS/ -- HL-24105/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272392" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin I/*analysis ; Angiotensin II/*analysis ; Angiotensins/*analysis ; Animals ; Cell Line ; Cricetinae ; Glioma/*metabolism ; Hybrid Cells/*metabolism ; Mice ; Neuroblastoma/*metabolism ; Peptidyl-Dipeptidase A/metabolism ; Radioimmunoassay ; Rats ; Renin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Insulin as a potent, specific growth factor in a rat hepatoma cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koontz, J W -- Iwahashi, M -- AM 24047/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):947-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Line ; *Growth Substances ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/*pathology ; Mitosis/drug effects ; Proinsulin/pharmacology ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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  • 7
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    A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnani, J L -- Brockhaus, M -- Smith, D F -- Ginsburg, V -- Blaszczyk, M -- Mitchell, K F -- Steplewski, Z -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):55-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209516" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*immunology ; Antibodies, Neoplasm/*immunology ; Antibody Specificity ; Antigens, Neoplasm/*immunology/isolation & purification ; Cell Line ; Chromatography, Thin Layer ; Colonic Neoplasms/*immunology ; Gangliosides/*immunology/isolation & purification ; Humans ; Melanoma/immunology ; Neuraminidase/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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  • 9
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    Human lupus inclusions and interferon (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: Raji cells, a human B lymphoblastoid cell line of Burkitt lymphoma origin, formed lupus inclusions when grown in a medium conditioned by the growth of Raji cells whose DNA thymidine residues had been unifilarly (single-strandedly) substituted with bromodeoxyuridine. Ultracentrifugation of this medium in excess of that required to remove Epstein-Barr virus and all other known mammalian viruses did not prevent the formation of the inclusions, and treatment of the conditioned medium with pronase destroyed the activity. These results demonstrate the presence of a protein that is secreted from bromodeoxyuridine-substituted Raji cells and is capable of inducing nonbromodeoxyuridine-substituted cells to form lupus inclusions. Interferon (100 units per milliliter) was found in the conditioned medium. Inclusions also formed in Raji cells grown in fresh medium supplemented with human leukocyte or fibroblast interferon (100 units per milliliter).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, S A -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):772-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6166984" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/*metabolism ; Burkitt Lymphoma ; Cell Line ; Culture Media ; Cytoplasmic Granules/ultrastructure ; DNA Replication ; Humans ; Interferons/*biosynthesis ; Lupus Erythematosus, Systemic/*pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 10
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    Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzmann, G -- Wiegandt, H -- Rose, B -- Zimmerman, A -- Ben-Haim, D -- Loewenstein, W R -- CA 14464/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chironomidae ; Fluorescent Dyes ; Glycopeptides/*metabolism ; Intercellular Junctions/*ultrastructure ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligosaccharides/*metabolism ; Protein Conformation ; Salivary Glands/*ultrastructure ; Species Specificity
    Print ISSN: 0036-8075
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  • 11
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    Tumor cell killing by phorbol ester--differentiated human leukemia cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, J B -- 27070-02/PHS HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cell Line ; *Cytotoxicity, Immunologic ; Humans ; Immunity, Cellular ; Leukemia, Experimental/immunology/*pathology ; Macrophages/cytology/*immunology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
    Print ISSN: 0036-8075
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  • 12
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    Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoneda, T -- Pratt, R M -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017936" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cell Line ; DNA Replication/drug effects ; Embryo, Mammalian ; Epidermal Growth Factor/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Kinetics ; Organ Specificity ; Ornithine Decarboxylase/metabolism ; Palate/drug effects/*physiology ; Peptides/*pharmacology ; Pregnancy
    Print ISSN: 0036-8075
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  • 13
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    Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: The ability of murine tumor cells to metastasize spontaneously from subcutaneous sites is positively correlated with the total sialic acid content of the cells in culture, the degree to which the sialic acid is exposed on the tumor cell surface, and, most strongly, with the degree of sialylation of galactosyl and N-acetylgalactosaminyl residues in cell surface glycoconjugates. These findings suggest that sialic acid on the cell surface may play a role in tumor cell metastasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yogeeswaran, G -- Salk, P L -- CA19312-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233237" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/*physiology ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Mice ; *Neoplasm Metastasis ; Neoplasms, Experimental/*physiopathology ; Sialic Acids/*analysis
    Print ISSN: 0036-8075
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  • 14
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    Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- Summerhayes, I C -- Chen, L B -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*drug therapy ; Cell Line ; Cell Survival/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasms, Experimental/drug therapy ; Rhodamine 123 ; Rhodamines/metabolism/therapeutic use ; Time Factors ; Urinary Bladder Neoplasms/drug therapy
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  • 15
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
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  • 16
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    Evidence for the clonal origin of spontaneous metastases (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmadge, J E -- Wolman, S R -- Fidler, I J -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6953592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Aberrations ; Genetic Markers ; Karyotyping ; Lung Neoplasms/secondary ; Melanoma ; Mice ; Mice, Inbred C3H ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology
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  • 17
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    Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: The transmission of adult T cell leukemia virus, a human retrovirus, into fresh leukocytes from normal humans was examined. One of three virus-carrying cell lines, tested after being subjected to lethal x-irradiation, consistently transformed leukocytes from adult peripheral blood and umbilical cord blood. All the transformed cell lines expressed adult T cell leukemia virus-associated antigen, but transformed lines originating from adult and umbilical cord blood exhibited T cell and non-T, non-B cell surface natures, respectively. Efforts to transform human leukocytes with cell-free virus were unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, N -- Okada, M -- Koyanagi, Y -- Kannagi, M -- Hinuma, Y -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6980467" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Cell Line ; Fetal Blood ; Genes, Viral ; Humans ; Karyotyping ; Leukocytes/*physiology ; Retroviridae/*genetics ; T-Lymphocytes/immunology ; *Transformation, Genetic
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  • 18
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    High efficiency DNA-mediated transformation of primate cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-05
    Description: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
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  • 19
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    Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-09
    Description: Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis. Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magrath, I -- Erikson, J -- Whang-Peng, J -- Sieverts, H -- Armstrong, G -- Benjamin, D -- Triche, T -- Alabaster, O -- Croce, C M -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1094-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316501" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/complications ; Antigens, Viral/analysis ; Burkitt Lymphoma/complications/*genetics ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/analysis ; Homosexuality ; Humans ; Immunoglobulin Light Chains/*biosynthesis ; Immunoglobulin kappa-Chains/*biosynthesis ; Male ; Oncogenes
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  • 20
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    DNA methylation decreases in aging but not in immortal cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-03
    Description: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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  • 21
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    Bacterial contamination of human tumor samples (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 Aug 17;225(4663):670-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087452" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinoma, Hepatocellular/genetics ; Cell Line ; DNA, Bacterial ; *DNA, Neoplasm ; DNA, Viral ; Hepatitis B virus/genetics ; Humans ; Liver Neoplasms/genetics ; Oncogenes
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  • 22
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    Biotechnology as an intellectual property (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-27
    Description: Recent advances in biotechnology have created many public policy and legal issues, one of the most significant of which is the treatment of biotechnological industrial products, particularly under the patent system. Patents represent one of several types of intellectual property; their ownership confers the right to exclude others from benefitting from the tangible products of a proprietary subject matter. Intellectual property law and its protections will play a major role in the rate at which biotechnology develops in the United States. In this article biotechnological intellectual property issues are reviewed in the context of their underlying legal requirements. The implications of other factors, such as international competition, research funding, and gene ownership, are also considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, R G -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):357-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6584975" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Cell Line ; Copyright ; DNA, Recombinant ; Economic Competition ; Federal Government ; *Genetic Engineering ; *Genetics, Microbial ; Government Regulation ; Legislation as Topic ; Ownership ; *Patents as Topic ; Research ; *Technology ; United States ; as a question of intellectual property rights. Attention is focused on the major ; role played by the U.S. patent system in establishing such rights, as illustrated ; by the case of products of recombinant DNA research. Trade secret, copyright, and ; trademark protections are also considered, as are policy issues such as ; international competition in the development of biomedical technologies and ; financing arrangements.
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  • 23
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    Stress hormones: their interaction and regulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: Stress stimulates several adaptive hormonal responses. Prominent among these responses are the secretion of catecholamines from the adrenal medulla, corticosteroids from the adrenal cortex, and adrenocorticotropin from the anterior pituitary. A number of complex interactions are involved in the regulation of these hormones. Glucocorticoids regulate catecholamine biosynthesis in the adrenal medulla and catecholamines stimulate adrenocorticotropin release from the anterior pituitary. In addition, other hormones, including corticotropin-releasing factor, vasoactive intestinal peptide, and arginine vasopressin stimulate while the corticosteroids and somatostatin inhibit adrenocorticotropin secretion. Together these agents appear to determine the complex physiologic responses to a variety of stressors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Axelrod, J -- Reisine, T D -- New York, N.Y. -- Science. 1984 May 4;224(4648):452-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6143403" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Adrenal Cortex/metabolism ; Adrenal Medulla/metabolism ; Adrenocorticotropic Hormone/*metabolism ; Animals ; Brain/metabolism ; Catecholamines/*metabolism ; Cell Line ; Corticotropin-Releasing Hormone/metabolism ; Cyclic AMP/metabolism ; Glucocorticoids/*metabolism ; Humans ; Phospholipases A/metabolism ; Pituitary Gland, Anterior/metabolism ; Receptors, Adrenergic, alpha/metabolism ; Receptors, Adrenergic, beta/metabolism ; Receptors, Cell Surface/metabolism ; Receptors, Corticotropin-Releasing Hormone ; Receptors, Somatostatin ; Somatostatin/pharmacology ; Stress, Physiological/*metabolism ; Stress, Psychological/metabolism ; Sympathetic Nervous System/metabolism ; Vasoactive Intestinal Peptide/pharmacology ; Vasopressins/pharmacology
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    Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-12
    Description: A novel eukaryotic hybrid gene has been constructed from the 5' sequence of a rat gene and the bacterial neomycin-resistance gene. After transfection into hamster fibroblasts, the neo transcripts can be induced to high levels by the absence of glucose. Furthermore, this hybrid gene can be regulated by temperature when it is introduced into a temperature-sensitive mutant cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Attenello, J W -- Lee, A S -- CA-27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):187-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cricetinae ; DNA, Recombinant ; Drug Resistance, Microbial ; Fibroblasts ; *Gene Expression Regulation ; Genes, Bacterial ; *Genes, Regulator ; Glucose/*pharmacology ; *HSP70 Heat-Shock Proteins ; Membrane Proteins/biosynthesis/*genetics ; Mutation ; Neomycin/pharmacology ; Rats ; Temperature ; Transcription, Genetic ; Transfection
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  • 25
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    T-cell growth factor gene: lack of expression in human T-cell leukemia-lymphoma virus-infected cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: Activated mature T cells require T-cell growth factor (TCGF) for continuous proliferation. However, many mature T cells infected with human T-cell leukemia-lymphoma virus grow independently of exogenously added TCGF. It is now reported that cells infected with this virus also lack detectable TCGF messenger RNA (less than one copy per cell) and thus do not produce their own growth factor. The results apparently rule out an autostimulation mechanism of growth control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arya, S K -- Wong-Staal, F -- Gallo, R C -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1086-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320374" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Deltaretrovirus/*physiology ; *Gene Expression Regulation/drug effects ; Humans ; Interferon-gamma/genetics ; Interleukin-2/*genetics ; Phytohemagglutinins/pharmacology ; RNA, Messenger/*genetics ; T-Lymphocytes/metabolism/*microbiology ; Tetradecanoylphorbol Acetate/pharmacology
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  • 26
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    Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: Bromodeoxyuridine (BrdUrd) treatment of the prolactin nonproducing subclone of GH cells (rat pituitary tumor cells) induces amplification of a 20-kilobase DNA fragment including all of the prolactin gene coding sequences. This amplified DNA segment, which is flanked by two unamplified regions, thus designates a unit of BrdUrd-induced amplified sequence. Cloned DNA segments, 10.3 kilobases long, from the 5' end of the rat prolactin gene of BrdUrd-responsive and -nonresponsive cells, were ligated to the thymidine kinase gene of herpes simplex virus type 1 (HSV1TK), and the hybrid DNA was transferred to thymidine kinase-deficient mouse fibroblast cells by transfection. The HSV1TK gene and the rat prolactin gene were amplified together in drug-treated transfectants carrying the hybrid DNA HSV1TK gene and rat prolactin gene of BrdUrd-responsive GH cells. These results suggest that the 10.3-kilobase DNA segment at the 5' end of the rat prolactin gene of BrdUrd-responsive GH cells carries the information for drug-induced gene amplification (amplicon) and that another gene, such as the HSV1TK gene, is also amplified when the latter is placed adjacent to this segment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biswas, D K -- Hartigan, J A -- Pichler, M H -- CA28218/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):941-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089335" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Bromodeoxyuridine/*pharmacology ; Cell Line ; Cloning, Molecular ; DNA/*genetics ; DNA, Recombinant ; *Gene Amplification ; Genes, Viral ; Mice ; Prolactin/genetics ; Rats ; Simplexvirus/genetics ; Thymidine Kinase/genetics ; Transfection
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    Insulin receptor: evidence that it is a protein kinase (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-21
    Description: Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor. This subunit of the insulin receptor was also labeled with [alpha-32P]8-azidoadenosine 5'-triphosphate, a photoaffinity label for adenosine triphosphate binding sites. The identity of the 95,000-dalton band was confirmed in both cases by precipitation with a monoclonal antibody to the insulin receptor. These results suggest that the insulin receptor is itself a protein kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, R A -- Cassell, D J -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849137" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Cell Line ; Cells, Cultured ; Lymphocytes ; Molecular Weight ; Phosphoproteins/physiology ; Protein Kinases/*physiology ; Receptor, Insulin/*physiology
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  • 28
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    Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: Normal bone marrow cells from a donor positive for herpes simplex virus were transformed with Epstein-Barr virus. The resulting lymphoblastoid cell line has secreted immunoglobulin G1 of the kappa type continuously for 2 years. This immunoglobulin, detected both on the cell surface and in the cytoplasm, reacts with cells infected with herpes simplex virus. It defines an antigen that comigrates with the 55-kilodalton glycoprotein D of herpes simplex virus type 1 and neutralizes the infectivity of herpes simplex viruses 1 and 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seigneurin, J M -- Desgranges, C -- Seigneurin, D -- Paire, J -- Renversez, J C -- Jacquemont, B -- Micouin, C -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304881" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Antibodies, Monoclonal/*immunology ; B-Lymphocytes/immunology ; Bone Marrow/*immunology ; Bone Marrow Cells ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/immunology ; Simplexvirus/*immunology ; Viral Envelope Proteins ; Viral Proteins/*immunology
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  • 29
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    Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-06
    Description: Expression of the cellular abl (c- abl ) oncogene was studied in K-562 and other chronic myelogenous leukemia (CML) cells and cell lines by means of Northern blot hybridization. In contrast to non-CML cells, which contained 7.4- and 6.8-kilobase abl -related transcripts, the CML cells contained a predominant and novel 8.2-kilobase abl -related RNA. In addition, the levels of abl -related message were up to eight times higher in CML cell lines from patients at the blast crisis stage of the disease compared with CML cells obtained during the chronic phase and with non-CML cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, S J -- Kubonishi, I -- Miyoshi, I -- Groudine, M T -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):72-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; DNA, Neoplasm/genetics ; Humans ; Leukemia, Myeloid/*genetics ; Mice ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/genetics ; *Transcription, Genetic
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  • 30
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    Bovine x mouse hybridomas that secrete bovine immunoglobulin G1 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: The interspecific fusion of normal bovine lymphocytes with a nonsecreting mouse hybridoma produced stable cell lines secreting bovine immunoglobulins. One of these lines has continued to secrete immunoglobulin G1 (5 to 10 micrograms per milliliter) for over 16 months. The bovine x mouse hybrid cells can be expected to provide bovine monoclonal immunoglobulins for sequencing studies and for use as serological standards as well as to provide messenger RNA for cloning bovine immunoglobulin genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Srikumaran, S -- Guidry, A J -- Goldsby, R A -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):522-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/biosynthesis ; Cattle ; Cell Line ; Hybridomas/*immunology ; Immunoglobulin G/*biosynthesis/immunology/isolation & purification ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Immunoglobulin M/immunology ; Mice ; Radioimmunoassay
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  • 31
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    Serological visualization of interleukin 2 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: Interleukin 2, a lymphokine that acts as a second signal of cellular immune response by way of its action as a T-cell growth factor, was morphologically identified by immunoperoxidase staining. With the use of a monoclonal antibody to interleukin 2 and several complex-forming antisera, the lymphokine was readily distinguished in cytocentrifuge preparations of peripheral blood leukocytes stimulated with a T-cell mitogen. When preparations of cloned interleukin 2 producer and responder cells were stained by the same procedures, discrete patterns of both responder and producer cell phenotypes were revealed. Interleukin 2 producer T cells exhibited a characteristic intense, ringlike cytoplasmic staining, whereas the responder cells (as exemplified by interleukin 2-dependent cell lines) exhibited a less intensive, spotlike membrane staining. In addition, intense membrane localization of interleukin 2, reminiscent of potential capping phenomena, could be observed in stained preparations of cloned responder cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinmann, G -- Conlon, P -- Hefeneider, S -- Gillis, S -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344215" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/immunology ; Cell Line ; Humans ; Immunoenzyme Techniques ; Interleukin-2/*physiology ; Leukocytes/physiology ; Mice ; T-Lymphocytes/physiology
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  • 32
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    Reinitiation of growth in senescent mouse mammary epithelium in response to cholera toxin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: Several lines of mouse mammary tissue that had been serially transplanted until mitotic senescence was reached were exposed in vivo to plastic implants that slowly released cholera toxin. Gland tissue surrounding the implants displayed new end buds, indicating reinitiation of growth and morphogenesis. The ability of cholera toxin, which elevates intracellular adenosine 3',5'-monophosphate, to temporarily reverse the senescent phenotype suggests that this mitotic dysfunction results not from generalized cellular deterioration but from specific changes in cell regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniel, C W -- Silberstein, G B -- Strickland, P -- 1050/PHS HHS/ -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1245-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328652" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*drug effects ; Cell Line ; Cholera Toxin/*pharmacology ; Cyclic AMP/physiology ; DNA/biosynthesis ; Epithelium/drug effects ; Female ; Fibroblasts/drug effects ; Humans ; Mammary Glands, Animal/*drug effects ; Mice ; Mice, Inbred BALB C ; Mitosis/drug effects
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    A new type D retrovirus isolated from macaques with an immunodeficiency syndrome (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-02-10
    Description: Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniel, M D -- King, N W -- Letvin, N L -- Hunt, R D -- Sehgal, P K -- Desrosiers, R C -- R01-A1 20729/PHS HHS/ -- RR00168/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):602-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burkitt Lymphoma ; Cell Line ; Humans ; Immunologic Deficiency Syndromes/*microbiology ; Macaca ; Nucleic Acid Hybridization ; Retroviridae/genetics/immunology/*isolation & purification
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  • 34
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    Nucleotide sequence of a human Blym transforming gene activated in a Burkitt's lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-03
    Description: The nucleotide sequence of a human Blym-1 transforming gene activated in a Burkitt's lymphoma cell line was determined. This sequence predicts a small protein of 58 amino acids that is 33 percent identical to the predicted product of chicken Blym-1, the activated transforming gene of chicken B cell lymphomas. Both the human and chicken Blym-1 genes exhibit significant identity to an amino-terminal region of transferrins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, A -- Devine, J M -- Cooper, G M -- CA 07250/CA/NCI NIH HHS/ -- CA 28946/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):516-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330897" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Burkitt Lymphoma/*genetics ; Cell Line ; *Cell Transformation, Neoplastic ; DNA Restriction Enzymes ; Humans ; *Oncogenes ; Structure-Activity Relationship ; Transcription, Genetic ; Transferrin/genetics
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  • 35
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    Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-14
    Description: Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is a lymphokine that acts to localize granulocytes. Medium conditioned by the Mo human T-lymphoblast cell line was used to purify NIF-T, a glycoprotein with a molecular weight of 22,000. The NIF-T was found to potently stimulate the growth of granulocyte and macrophage colonies from human bone marrow and colony formation by the KG-1 myeloid leukemia cell line. Thus a human lymphokine (NIF-T) that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gasson, J C -- Weisbart, R H -- Kaufman, S E -- Clark, S C -- Hewick, R M -- Wong, G G -- Golde, D W -- CA 30280/CA/NCI NIH HHS/ -- CA 30388/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1339-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6390681" target="_blank"〉PubMed〈/a〉
    Keywords: Bone Marrow Cells ; Cell Division ; Cell Line ; Chromatography, High Pressure Liquid ; Colony-Stimulating Factors/*isolation & purification ; Electrophoresis, Polyacrylamide Gel ; Granulocytes/*cytology ; Humans ; Leukocyte Migration-Inhibitory Factors/*pharmacology ; Lymphokines/*pharmacology ; Macrophages/*cytology ; Molecular Weight
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  • 36
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    Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-13
    Description: To study the mode of action of human cytomegalovirus, an important teratogenic agent in human populations, the susceptibility of a pluripotent human embryonal carcinoma cell line to the virus was investigated. Viral antigens were not expressed nor was infectious virus produced by human embryonal carcinoma cells after infection, although the virus was able to penetrate these cells. In contrast, retinoic acid-induced differentiated derivatives of embryonal carcinoma cells were permissive for antigen expression and infectious virus production. Replication of human cytomegalovirus in human teratocarcinoma cells may therefore depend on cellular functions associated with differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonczol, E -- Andrews, P W -- Plotkin, S A -- AI-14927/AI/NIAID NIH HHS/ -- CA-29894/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 13;224(4645):159-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322309" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Transformation, Neoplastic/drug effects/metabolism ; Cell Transformation, Viral/drug effects ; Cytomegalovirus/*physiology ; Embryonal Carcinoma Stem Cells ; Humans ; Neoplastic Stem Cells/*microbiology ; Stem Cells/*microbiology ; Teratoma/*microbiology ; Tretinoin/pharmacology ; *Virus Replication
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  • 37
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    Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-23
    Description: Platelet-derived growth factor (PDGF) has been previously shown to be homologous to the transforming gene of simian sarcoma virus (v-sis), and inappropriate expression of the cellular counterpart of the v-sis gene (c-sis) has been implicated in the generation of mesenchymal tumors. The U-2 OS human osteosarcoma line was shown to contain multiple c-sis transcripts. Immunoprecipitation experiments with antiserum to PDGF identified a variety of polypeptides ranging in size from 18,000 to 165,000 daltons that were immunoprecipitated specifically from U-2 OS cell extracts. The osteosarcoma also was shown to secrete a 29,000-dalton protein having the serological and structural characteristics of PDGF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graves, D T -- Owen, A J -- Barth, R K -- Tempst, P -- Winoto, A -- Fors, L -- Hood, L E -- Antoniades, H N -- CA30101/CA/NCI NIH HHS/ -- HL27607/HL/NHLBI NIH HHS/ -- HL29583/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):972-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6209798" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; DNA Replication ; Humans ; Molecular Weight ; Neoplasm Proteins/*genetics ; *Oncogenes ; Osteosarcoma/*genetics ; *Platelet-Derived Growth Factor ; Poly A/genetics/isolation & purification ; RNA/genetics/isolation & purification ; RNA, Messenger ; *Transcription, Genetic
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  • 38
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    Activated expression of the N-myc gene in human neuroblastomas and related tumors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-14
    Description: In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in the absolute amount of expression of each N-myc gene and (ii) an increase in the copy number of the N-myc gene. A second gene--which is amplified in many of the same lines as N-myc--is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N-myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N-myc gene copy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohl, N E -- Gee, C E -- Alt, F W -- 2-P01 CA 23767-06/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1335-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505694" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; *Gene Amplification ; Gene Expression Regulation ; Humans ; Neuroblastoma/*genetics ; *Oncogenes ; RNA, Messenger/metabolism
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  • 39
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    Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-05
    Description: Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, T H -- Coligan, J E -- Sodroski, J G -- Haseltine, W A -- Salahuddin, S Z -- Wong-Staal, F -- Gallo, R C -- Essex, M -- 2-T32-CA0903/CA/NCI NIH HHS/ -- CA07094/CA/NCI NIH HHS/ -- CA13885/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):57-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089350" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antigens, Viral/*genetics ; Base Sequence ; Cell Line ; Cyanogen Bromide ; Deltaretrovirus/*genetics/immunology ; *Genes, Viral ; Humans ; Peptide Fragments ; Trans-Activators ; Viral Proteins/*genetics
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  • 40
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    Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-24
    Description: Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, J A -- Hoffman, A D -- Kramer, S M -- Landis, J A -- Shimabukuro, J M -- Oshiro, L S -- CA-34980/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):840-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206563" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/immunology/*microbiology ; Antibodies, Viral/analysis ; Bone Marrow/microbiology ; California ; Cell Line ; Cells, Cultured ; Cross Reactions ; Cytopathogenic Effect, Viral ; Deltaretrovirus/immunology/*isolation & purification/physiology/ultrastructure ; *Homosexuality ; Humans ; Leukocytes/microbiology ; Lymphatic Diseases/immunology ; Male ; RNA-Directed DNA Polymerase/metabolism ; Syndrome ; T-Lymphocytes ; Virus Cultivation
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  • 41
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    Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: In order to further define the mechanisms by which polypeptide growth factors regulate gene transcription and cellular growth, expression cloning techniques were used to select human epidermal growth factor (EGF) receptor complementary DNA clones. The EGF 3' coding domain shows striking homology to the transforming gene product of avian erythroblastosis virus (v-erbB). Over-expression of EGF receptors in A431 cell lines correlates with increased EGF receptor mRNA levels and amplification (up to 110 times) of the apparently singular EGF receptor gene. There appear to be three cytoplasmic polyadenylated RNA products of EGF receptor gene expression in A431 cells, one of which contains only 5' (EGF binding domain) sequences and is postulated to encode the secreted EGF receptor-related protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, C R -- Chen, W S -- Kruiger, W -- Stolarsky, L S -- Weber, W -- Evans, R M -- Verma, I M -- Gill, G N -- Rosenfeld, M G -- New York, N.Y. -- Science. 1984 May 25;224(4651):843-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326261" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cell Line ; Cloning, Molecular ; DNA/*genetics ; Gene Amplification ; Gene Expression Regulation ; Polymorphism, Genetic ; RNA, Messenger/genetics ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*genetics
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  • 42
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    Transfection of the DNA polymerase-alpha gene (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-16
    Description: DNA polymerase-alpha is the major replicative DNA polymerase in animal cells. The gene coding for a mutant DNA polymerase-alpha was transferred from one cell to another by transfection of DNA from mutant cells. The DNA was isolated from a mutant hamster cell line resistant to aphidicolin, a specific inhibitor of DNA polymerase-alpha, and transferred into an aphidicolin-sensitive cell line. The resulting transfectants exhibited increased survival in the presence of aphidicolin and contained an aphidicolin-resistant DNA polymerase-alpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, P K -- Loeb, L A -- CA07418/CA/NCI NIH HHS/ -- CA24845/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):833-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436977" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aphidicolin ; Cell Line ; Clone Cells ; Cricetinae ; Cricetulus/genetics ; DNA Polymerase II/*genetics ; Diterpenes/pharmacology ; Escherichia coli/genetics ; Humans ; Mice ; Mutation ; Salmon/genetics ; *Transfection
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  • 43
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    Proliferation of astroglia and oligodendroglia in response to human T cell-derived factors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-29
    Description: Human T lymphocytes transformed by human T cell leukemia-lymphoma viruses or activated by lectins were found to produce stimulating factors that promoted both proliferation and maturation of oligodendroglial and astroglial cells in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merrill, J E -- Kutsunai, S -- Mohlstrom, C -- Hofman, F -- Groopman, J -- Golde, D W -- CA 30388/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1428-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6610212" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Astrocytes/*drug effects ; Cell Division/*drug effects ; Cell Line ; Growth Substances/*pharmacology ; Humans ; Lymphocyte Activation ; Lymphokines/pharmacology ; Neuroglia/*drug effects ; Oligodendroglia/*drug effects ; Rats ; Receptors, Fc/metabolism ; T-Lymphocytes/*physiology
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  • 44
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    Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-27
    Description: The sequence of the human epidermal growth factor (EGF) receptor shows great homology with the avian erythroblastosis virus v-erb B oncogene, raising the possibility that the receptor gene is identical to the c-erb B protooncogene. Human A431 epidermoid carcinoma cells, which have an unusually high number of EGF receptors, were examined to determine whether elevated EGF receptor levels correlate with gene amplification. Southern blots of genomic DNA's from A431 and other human cell lines were probed with either a v-erb B gene fragment or a human EGF receptor complementary DNA clone (pE7), previously isolated from an A431 complementary DNA library. When either probe was used to analyze Eco RI- or Hind III-generated DNA fragments, EGF receptor DNA sequences were amplified about 30-fold in A431. Differences in the banding pattern of A431 DNA fragments relative to normal fibroblast DNA indicate the occurrence of a rearrangement in the region of the receptor gene. Furthermore, A431 cells contain a characteristic, prominent 2.9-kilobase RNA. These results are consistent with the hypothesis that, in A431 cells, gene amplification, possibly associated with a translocation event, may result in the overproduction of EGF receptor protein or the appearance of the transformed phenotype (or both).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merlino, G T -- Xu, Y H -- Ishii, S -- Clark, A J -- Semba, K -- Toyoshima, K -- Yamamoto, T -- Pastan, I -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200934" target="_blank"〉PubMed〈/a〉
    Keywords: Alpharetrovirus/genetics ; Base Sequence ; Carcinoma, Squamous Cell ; Cell Line ; Dna ; DNA Restriction Enzymes ; Epidermal Growth Factor/metabolism ; *Gene Amplification ; Genes, Viral ; Humans ; Nucleic Acid Hybridization ; Oncogenes ; Poly A/genetics ; RNA/genetics ; RNA, Messenger ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/biosynthesis/*genetics ; Translocation, Genetic
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  • 45
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    Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-10
    Description: 3-Aminobenzamide and benzamide, purported to be specific inhibitors of the synthesis of poly(adenosine diphosphate-ribose), were used to elucidate possible functions of this biopolymer. These compounds, at frequently used experimental concentrations, not only inhibited the action of poly(adenosine diphosphate-ribose) synthetase but also affected cell viability, glucose metabolism, and DNA synthesis. Thus, the usefulness of 3-aminobenzamide and benzamide may be severely restricted by the difficulty of finding a dose small enough to inhibit the synthetase without producing additional metabolic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Milam, K M -- Cleaver, J E -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):589-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6420886" target="_blank"〉PubMed〈/a〉
    Keywords: Benzamides/*toxicity ; Cell Line ; DNA Replication/drug effects ; Humans ; Kinetics ; Lymphocytes ; Nucleoside Diphosphate Sugars/*biosynthesis ; Poly Adenosine Diphosphate Ribose/*biosynthesis ; Poly(ADP-ribose) Polymerases/metabolism ; Structure-Activity Relationship
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  • 46
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    Infectious and selectable retrovirus containing an inducible rat growth hormone minigene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: A growth hormone minigene carrying its natural promoter (237 nucleotides of chromosomal DNA) was stably propagated in a murine retrovirus containing hypoxanthine-guanine phosphoribosyltransferase as a selectable marker. Glucocorticoid and thyroid hormone inducibility was transferred with the growth hormone gene. Recombinant virus with titers of 10(6) per milliliter was recovered. This demonstration that retroviruses can be used to transfer a nonselectable gene under its own regulatory control enlarges the scope of retroviral vectors as potent tools for gene transfer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, A D -- Ong, E S -- Rosenfeld, M G -- Verma, I M -- Evans, R M -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):993-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; DNA, Recombinant ; DNA, Viral/analysis ; Dexamethasone/pharmacology ; Gene Expression Regulation ; *Genes ; Genes, Viral ; Genetic Markers ; *Genetic Vectors ; Growth Hormone/biosynthesis/*genetics ; Hypoxanthine Phosphoribosyltransferase/genetics ; Mice ; Operon ; Phenotype ; RNA, Viral/genetics ; Rats ; Retroviridae/*genetics ; Transcription, Genetic ; Transfection ; Triiodothyronine/pharmacology
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  • 47
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    Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-06
    Description: A strain of lymphadenopathy associated retrovirus ( LAV ) passaged in vitro was used to infect a lymphoblastoid cell line obtained by transformation with Epstein-Barr virus of B lymphocytes from a healthy donor. The virus produced from this line (B- LAV ) was also able to grow at a high rate in some other lymphoblastoid lines and in a Burkitt lymphoma line. This adapted strain retained the biochemical, ultrastructural, and antigenic characteristics of the original strain, as well as its tropism for normal T4+ lymphocytes. It is thus possible to grow LAV in large quantities that can be used for the preparation of diagnostic reagents. The interaction between such a human retrovirus and Epstein-Barr virus, a DNA virus, may have some implication for the pathology of the acquired immunodeficiency syndrome and related diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Montagnier, L -- Gruest, J -- Chamaret, S -- Dauguet, C -- Axler, C -- Guetard, D -- Nugeyre, M T -- Barre-Sinoussi, F -- Chermann, J C -- Brunet, J B -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):63-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328661" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/microbiology ; Antibodies, Monoclonal/immunology ; B-Lymphocytes/*microbiology ; Cell Line ; Cell Transformation, Viral ; Deltaretrovirus/metabolism ; Herpesvirus 4, Human/*metabolism ; Humans ; Retroviridae/*growth & development ; T-Lymphocytes/microbiology ; *Virus Replication
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    Organ-specific adhesion of metastatic tumor cells in vitro (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: Binding of tumor cells to cryostat sections of host organs was studied. B16-F10 melanoma cells and reticulum cell sarcoma cells demonstrated an organ specificity in their binding in vitro that reflected the organ specificity of their metastatic distribution 25 days after intravenous injection. These results provide evidence for specific binding of tumor cells to the tissues that they selectively colonize in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Netland, P A -- Zetter, B R -- 5 T32 GM 07258/GM/NIGMS NIH HHS/ -- R01 CA 28540/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1113-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372098" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesiveness ; Animals ; Cell Line ; Humans ; Liver/physiopathology ; Lung/physiopathology ; Lymphoma, Large B-Cell, Diffuse/physiopathology ; Melanoma/physiopathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasm Metastasis/physiopathology ; Neoplasms/*physiopathology ; Neoplasms, Experimental/physiopathology ; *Organ Specificity
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    Lymphokine production by cultured human T cells transformed by human T-cell leukemia-lymphoma virus-I (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-17
    Description: Cell-free conditioned media from human T cells transformed by human T-cell leukemia-lymphoma virus (HTLV-I) were tested for the production of soluble biologically active factors, including several known lymphokines. The cell lines used were established from patients with T-cell leukemia-lymphoma and from human umbilical cord blood and bone marrow leukocytes transformed by HTLV-I in vitro. All of the cell lines liberated constitutively one or more of the 12 biological activities assayed. These included macrophage migration inhibitory factor (MIF), leukocyte migration inhibitory factor (LIF), leukocyte migration enhancing factor (MEF), macrophage activating factor (MAF), differentiation inducing factor (DIF), colony stimulating factor (CSF), eosinophil growth and maturation activity (eos. GMA), fibroblast activating factor (FAF), gamma-interferon and, in rare instances, T-cell growth factor (TCGF). Some cell lines produced interleukin 3 (IL-3), platelet-derived growth factor (PDGF), or B-cell growth factors (BCGF). Such cells should prove useful for the production of lymphokines and as sources of specific messenger RNA's for their genetic cloning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salahuddin, S Z -- Markham, P D -- Lindner, S G -- Gootenberg, J -- Popovic, M -- Hemmi, H -- Sarin, P S -- Gallo, R C -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):703-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320367" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal ; Antigens, Neoplasm/analysis ; Bone Marrow ; Cell Line ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Deltaretrovirus/*genetics ; Female ; Humans ; Leukemia/*microbiology ; Lymphokines/*biosynthesis ; Lymphoma/*microbiology ; Phenotype ; Pregnancy ; T-Lymphocytes/*immunology
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    Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-07
    Description: The human T-cell leukemia (lymphotropic) virus type III (HTLV-III) appears to be central to the causation of the acquired immune deficiency syndrome (AIDS). Two full-length integrated proviral DNA forms of HTLV-III have now been cloned and analyzed, and DNA sequences of the virus in cell lines and fresh tissues from patients with AIDS or AIDS-related complex (ARC) have been characterized. The results revealed that (i) HTLV-III is an exogenous human retrovirus, approximately 10 kilobases in length, that lacks nucleic acid sequences derived from normal human DNA; (ii) HTLV-III, unlike HTLV types I and II, shows substantial diversity in its genomic restriction enzyme cleavage pattern; (iii) HTLV-III persists in substantial amounts in cells as unintegrated linear DNA, an uncommon property that has been linked to the cytopathic effects of certain animal retroviruses; and (iv) HTLV-III viral DNA can be detected in low levels in fresh (primary) lymphoid tissue of a minority of patients with AIDS or ARC but appears not to be present in Kaposi's sarcoma tissue. These findings have important implications concerning the biological properties of HTLV-III and the pathophysiology of AIDS and Kaposi's sarcoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, G M -- Hahn, B H -- Arya, S K -- Groopman, J E -- Gallo, R C -- Wong-Staal, F -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1165-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6095449" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Base Sequence ; Cell Line ; Child ; Cloning, Molecular ; Cytopathogenic Effect, Viral ; DNA Restriction Enzymes/metabolism ; DNA, Viral/*analysis ; Deltaretrovirus/*genetics ; Humans ; Male ; Nucleic Acid Hybridization
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    Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-06-08
    Description: A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma cell lines but not in cell lines from other tumor types. N-myc has now been found to be amplified in neuroblastoma tissue from 24 of 63 untreated patients (38 percent). The extent of amplification appears to be bimodal, with amplification of 100- to 300-fold in 12 cases and 3- to 10-fold in 10 others. Amplification was found in 0 of 15 patients with stage 1 or 2 disease, whereas 24 of 48 cases (50 percent) with stage 3 or 4 had evidence of N-myc amplification. These data indicate that N-myc amplification is a common event in untreated human neuroblastomas. Furthermore, N-myc amplification is highly correlated with advanced stages of disease (P less than 0.001) and with the ability to grow in vitro as an established cell line, both of which are associated with a poor prognosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodeur, G M -- Seeger, R C -- Schwab, M -- Varmus, H E -- Bishop, J M -- CA02971/CA/NCI NIH HHS/ -- CA13539/CA/NCI NIH HHS/ -- CA17829/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1121-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719137" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Cell Line ; Child ; Child, Preschool ; DNA, Neoplasm/genetics ; Eye Neoplasms/genetics ; *Gene Amplification ; Humans ; Infant ; Lymphatic Metastasis ; Middle Aged ; Neuroblastoma/*genetics/physiopathology ; Nucleic Acid Hybridization ; *Oncogenes ; Prognosis ; Retinoblastoma/genetics
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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    O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-24
    Description: Monoclonal antibody Mab D1.1 recognizes on human melanoma cells a ganglioside antigen characterized by an alkali-labile O-acetylated sialic acid residue. Immunochemical analysis showed that this molecule is an O-acetylated product of the neuroectoderm-associated disialoganglioside GD3. Controlled chemical O-acetylation of purified GD3 resulted in the generation of this same epitope. Lysates of human melanoma cells were found to contain O-acetyltransferase activity capable of generating the antigenic epitope recognized by Mab D1.1. Thus, the addition of a single O-acetyl group to a common cell surface-associated ganglioside can create a potentially tumor-specific antigen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheresh, D A -- Reisfeld, R A -- Varki, A P -- CA 07544/CA/NCI NIH HHS/ -- CA 28420/CA/NCI NIH HHS/ -- GM32373/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):844-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206564" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Acetyltransferases/metabolism ; Antibodies, Monoclonal ; Antigens, Neoplasm/*immunology ; Cell Line ; Epitopes/immunology ; Gangliosides/analysis/*immunology/metabolism ; Humans ; Melanoma/enzymology/*immunology
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    Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chafouleas, J G -- Bolton, W E -- Means, A R -- RR-05425/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6203171" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bleomycin/*pharmacology ; Calmodulin/*antagonists & inhibitors/*physiology ; Cell Division/drug effects ; Cell Line ; Cell Survival/drug effects ; Cricetinae ; Cricetulus ; DNA Repair/*drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Sulfonamides/pharmacology
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    Appearance of a new nucleosomal protein during differentiation of human leukemia (HL-60) cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-30
    Description: A 60-kilodalton protein was identified in chromatin digested by micrococcal nuclease during retinoic acid-induced differentiation of human leukemia (HL-60) cells to mature-like granulocytes. The protein was not detected in a retinoic acid-resistant variant of the HL-60 cell line treated with retinoic acid, in HL-60 cells induced with dimethyl sulfoxide, or in normal human granulocytes. This protein may have an important role in the regulation of retinoic acid-induced leukemic cell differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou, R H -- Chervenick, P A -- Barch, D R -- CA14278-08/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1420-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6583846" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Transformation, Neoplastic/drug effects ; Centrifugation, Density Gradient ; Dimethyl Sulfoxide/pharmacology ; Electrophoresis, Polyacrylamide Gel ; Granulocytes/metabolism ; Humans ; Leukemia, Myeloid, Acute/*metabolism ; Neoplasm Proteins/*isolation & purification ; Nucleosomes/*metabolism ; Tretinoin/pharmacology
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    Estrogen-dependent Leydig cell protein recognized by monoclonal antibody to MCF-7 cell line (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-26
    Description: A protein (27,000 molecular weight) was previously found in rat Leydig cells after treatment with estradiol (E2) and human chorionic gonadotropin (hCG) in vitro. The effect of hCG occurred through increased E2 production. This hormone-regulated rat testicular protein was compared to an estrogen-regulated protein of similar physical characteristics isolated from a human mammary cancer cell line (MCF-7) and present in normal human estrogen target organs. The Leydig cells from rat and human tissue showed specific immunofluorescence and immunoperoxidase staining in the cytoplasm upon incubation with a monoclonal antibody (C11) to the estrogen-regulated protein from MCF-7 cells. Leydig cells after exposure to E2 or hCG showed the highest fluorescence intensity; this intensity was reduced by treatment with Tamoxifen. No reaction was associated with other testicular cells. The estrogen-regulated protein from human cell lines is therefore immunologically similar to that from the rat Leydig cell. The monoclonal antibody should be useful for further characterization of the Leydig cell protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ciocca, D R -- Dufau, M L -- CA 11378/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):445-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387908" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; *Antibodies, Monoclonal ; Breast Neoplasms/metabolism ; Cell Line ; Chorionic Gonadotropin/pharmacology ; Cross Reactions ; Estradiol/pharmacology ; Fluorescent Antibody Technique ; Humans ; Immunoenzyme Techniques ; Leydig Cells/*analysis ; Male ; Middle Aged ; Proteins/*analysis ; Rats
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    Mo cell case has its first court hearing (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):813-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494909" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; California ; Cell Line ; *Human Body ; Humans ; *Jurisprudence ; Patents as Topic/legislation & jurisprudence ; *Patient Rights ; Spleen/cytology ; *Tissue and Organ Procurement ; Regents of the University of California on the grounds that two researchers at ; the Los Angeles campus took unfair advantage of him by misappropriating cells ; derived from his spleen in the course of leukemia therapy--cells that were then ; used in research that led to a patent. A federal court procedural hearing on 29 ; October 1984 yielded a ruling that the case will be heard in California state ; court, though it will probably be at least three years before a trial date can be ; scheduled. University officials and scientists see the case as an "outrageous" ; and legally unjustified attempt to assert a claim to the patent. Nevertheless, ; policy makers and university institutional review boards now face the question of ; whether, and how, consent forms should be rewritten to clarify the issue.
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    Induction of interleukin 2 messenger RNA inhibited by cyclosporin A (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-12-21
    Description: Cyclosporin A blocked production of the lymphokine interleukin 2 by activated T lymphocytes. In a human and a murine cell line this inhibition reflected an absence of interleukin 2 messenger RNA. Under conditions in which these cells are normally stimulated to secrete high levels of interleukin 2, they failed to do so in the presence of cyclosporin A. In both cell lines this failure was accompanied by an absence of interleukin 2 messenger accumulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elliott, J F -- Lin, Y -- Mizel, S B -- Bleackley, R C -- Harnish, D G -- Paetkau, V -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1439-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6334364" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cyclosporins/*pharmacology ; Humans ; Interleukin-2/biosynthesis/*genetics ; Mice ; Protein Biosynthesis/drug effects ; RNA, Messenger/*metabolism ; T-Lymphocytes/metabolism
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    Somatic activation of rasK gene in a human ovarian carcinoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-17
    Description: A tumor isolate from a patient with serous cystadenocarcinoma of the ovary contained an activated rasK gene detected hy transfection of NIH/3T3 cells. In contrast, DNA from normal cells of the same patient lacked transforming activity, indicating that activation of this transforming gene was the consequence of somatic mutation in the neoplastic cells. The transforming gene product displayed an electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gels that differed from the mobilities of rasK transforming proteins in other tumors, indicating that a previously undescribed mutation was responsible for activation of rasK in this ovarian carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feig, L A -- Bast, R C Jr -- Knapp, R C -- Cooper, G M -- CA07101/CA/NCI NIH HHS/ -- CA18689/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):698-701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Cell Transformation, Neoplastic ; Cystadenocarcinoma/*genetics ; DNA, Neoplasm/genetics/isolation & purification ; Female ; Humans ; Lung Neoplasms/genetics ; Mice ; *Oncogenes ; Ovarian Neoplasms/*genetics ; Transfection
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    Antigenic similarity between cells transformed by ultraviolet radiation in vitro and in vivo (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-02-10
    Description: Cells of the 10T 1/2 mouse fibroblast line transformed in vitro by ultraviolet radiation are antigenically similar to those from skin cancers produced in mice by repeated exposure to ultraviolet radiation. Both types of tumor cells grew preferentially in ultraviolet-irradiated syngeneic mice relative to untreated animals, and both were recognized by ultraviolet radiation-induced tumor-specific suppressor lymphocytes. These properties were not shared by 10T 1/2 cells transformed in vitro by x-rays or 3-methylcholanthrene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, M S -- Kripke, M L -- Chan, G L -- CA-09078/CA/NCI NIH HHS/ -- CA-11751/CA/NCI NIH HHS/ -- N01-CO-23909/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):593-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695169" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/*analysis ; Carcinogens ; Cell Line ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Mice ; Mice, Inbred C3H ; Neoplasm Transplantation ; Transplantation, Isogeneic ; *Ultraviolet Rays
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    A cell line expressing vesicular stomatitis virus glycoprotein fuses at low pH (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-17
    Description: A stable cell line expressing a complementary DNA clone encoding the vesicular stomatitis virus glycoprotein fused and formed polykaryons at pH 5.5. The formation of polykaryons was dependent on the presence of glycoprotein anchored at the cell surface and could be prevented by incubation of cells with a monoclonal antibody to the glycoprotein. Fusion occurred at a pH 0.5 unit lower than that observed for cells infected with vesicular stomatitis virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Florkiewicz, R Z -- Rose, J K -- 1 F32 AI06911-01/AI/NIAID NIH HHS/ -- AI15481/AI/NIAID NIH HHS/ -- CA 14195/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):721-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087454" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/metabolism ; *Cell Fusion ; Cell Line ; Cell Membrane/*metabolism ; Glycoproteins/*metabolism ; Hydrogen-Ion Concentration ; *Membrane Glycoproteins ; Mice ; Vesicular stomatitis Indiana virus/*metabolism ; *Viral Envelope Proteins ; Viral Proteins/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: Treatment of mice with the carcinogen N-methylnitrosourea results in the development of thymic lymphomas with frequent involvement of the N-ras oncogene. The activated mouse N-ras gene was isolated from one of these lymphomas and, by transformation in concert with restriction digestion, a map of the gene was prepared and its approximate boundaries were determined. By means of somatic cell hybrids the normal N-ras gene was found to be unlinked to other members of the ras gene family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero, I -- Villasante, A -- D'Eustachio, P -- Pellicer, A -- CA-16239/CA/NCI NIH HHS/ -- GM-32105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1041-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089339" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic ; Chromosome Mapping ; Cloning, Molecular ; Cricetinae ; DNA Restriction Enzymes ; Deoxyribonuclease EcoRI ; Genetic Linkage ; Hybrid Cells ; Lymphoma/chemically induced/*genetics ; Methylnitrosourea ; Mice ; Mice, Inbred Strains ; *Oncogenes ; Thymus Neoplasms/chemically induced/*genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Novel viral sequences related to human T-cell leukemia virus in T cells of a seropositive baboon (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Antibodies reactive with proteins of human T-cell leukemia virus (HTLV) can be found in Old World monkeys. A T-lymphocyte cell line established from a seropositive baboon (Papio cynocephalus) was analyzed for the presence of viral DNA sequences. The provirus found in these cells was related to but distinct from HTLV subgroup I. These results add to recent evidence from human studies that HTLV represents a spectrum of infectious T-lymphotropic retroviruses that includes closely and distantly related members.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guo, H G -- Wong-Stall, F -- Gallo, R C -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322297" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/analysis ; Antigens, Viral/immunology ; Base Sequence ; Cell Line ; DNA Restriction Enzymes ; DNA, Viral/*analysis ; Deltaretrovirus/*genetics/immunology ; *Genes, Viral ; Humans ; Nucleic Acid Hybridization ; Papio/immunology/*microbiology ; Repetitive Sequences, Nucleic Acid ; T-Lymphocytes/*analysis/microbiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Common region on chromosome 14 in T-cell leukemia and lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-21
    Description: Chromosome 14 breakpoints in malignant human lymphocytes cluster on the long (q) arm near bands q11 and q32. An inversion of chromosome 14 due to breaks in q11.2 and q32.3 has now been found in a newly established childhood T-cell lymphoma cell line and confirmed in T-cell chronic lymphocytic leukemia. A translocation was also found between chromosomes 10 and 14 with a breakpoint at 14q11.2 in another T-cell lymphoma cell line. It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function. Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T-cell malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hecht, F -- Morgan, R -- Hecht, B K -- Smith, S D -- 25055/PHS HHS/ -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1445-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6438800" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; *Chromosome Aberrations ; Humans ; Immunoglobulin Heavy Chains/genetics ; Leukemia, Lymphoid/*genetics ; Lymphoma/*genetics ; Male ; Middle Aged ; T-Lymphocytes ; Translocation, Genetic
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    Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: The ability of clonally derived lines of B16F1 and B16F10 melanoma cells to form experimental metastases in C57BL mice after intravenous injection was examined. Luria- Delbruck fluctuation analysis was applied to the results obtained with parallel subclones grown to small population sizes before testing for metastatic ability. The analysis demonstrated that variant cells capable of forming experimental metastases were generated in B16F1 cell populations at an effective rate of about 1.3 X 10(-5) per cell per generation while in B16F10 cell populations the effective rate of production was about 5 X 10(-5) per cell per generation. These results are consistent with a dynamic heterogeneity model of tumor progression. They suggest that the majority of cells in both lines are effectively nonmetastatic and that the higher metastatic ability of the B16F10 population may be due in part to a higher rate of generation of metastatic variants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, R P -- Chambers, A F -- Ling, V -- Harris, J F -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):998-1001.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Clone Cells ; Humans ; Melanoma/genetics/*physiopathology ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/physiopathology ; Neoplasms, Experimental/genetics/physiopathology ; Phenotype
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    Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: The tumor promoters 12-O-tetradecanoyl-phorbol-13-acetate and teleocidin markedly enhanced the transformation of C3H 10T1/2 mouse fibroblasts when these cells were transfected with the cloned human bladder cancer c-rasH oncogene. Transfection studies with the drug resistance marker gpt and time course studies indicate that this enhancement is not simply an effect on the process of DNA transfection. These findings, together with parallel studies with NIH 3T3 fibroblasts, also indicate that the competence of animal cells for DNA transfection is a function of the recipient cell line, the transfected marker, and the growth conditions. Our findings suggest that during multistage carcinogenesis tumor promoters may complement the function of activated cellular oncogenes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsiao, W L -- Gattoni-Celli, S -- Weinstein, I B -- CA 26056/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*pharmacology ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; DNA, Neoplasm/metabolism ; Humans ; Lyngbya Toxins/pharmacology ; Mice ; Mice, Inbred C3H ; Oncogenes/*drug effects ; Tetradecanoylphorbol Acetate/pharmacology ; Transfection/drug effects
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    Rat transforming growth factor type 1: structure and relation to epidermal growth factor (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: The complete amino acid sequence of rat transforming growth factor type 1 has been determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is structurally and functionally related to mouse epidermal growth factor and human urogastrone. Production of this polypeptide by various neoplastic cells might contribute to the continued expression of the transformed phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marquardt, H -- Hunkapiller, M W -- Hood, L E -- Todaro, G J -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1079-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320373" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; *Cell Transformation, Neoplastic ; DNA/biosynthesis ; Epidermal Growth Factor/*metabolism/pharmacology ; Humans ; Idoxuridine/metabolism ; Mice ; Peptide Biosynthesis ; Peptides/*metabolism/pharmacology ; Rats ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; Structure-Activity Relationship ; Transforming Growth Factors
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    Oncogenes amplified in cancer cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):40-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic ; Chromosome Aberrations ; *Gene Amplification ; Humans ; Leukemia/genetics ; Lung Neoplasms/genetics ; Neoplasms/*genetics/metabolism ; Neuroblastoma/genetics ; *Oncogenes ; RNA, Messenger/biosynthesis ; RNA, Neoplasm/biosynthesis ; Translocation, Genetic
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    Functional properties of antigen-specific T cells infected by human T-cell leukemia-lymphoma virus (HTLV-I) (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-28
    Description: Tetanus-toxoid specific helper-inducer T-cell clones, which had been infected and transformed by human T-cell leukemia-lymphoma virus (HTLV-I), were obtained from an antigen-specific human T cell line by using a limiting dilution technique in the presence of the virus. These HTLV-I-infected T-cell clones proliferated specifically in response to soluble tetanus toxoid but, unlike normal T cells, they could do so in the absence of accessory cells. The HTLV-I-infected T-cell clones did not present the antigen to autologous antigen-specific T cells that were not infected with HTLV-I. The capacity of helper-inducer T cells to retain antigen-specific reactivity after infection by HTLV-I, while losing the normal T-cell requirement for accessory cells, has clinical and theoretical implications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitsuya, H -- Guo, H G -- Cossman, J -- Megson, M -- Reitz, M S Jr -- Broder, S -- New York, N.Y. -- Science. 1984 Sep 28;225(4669):1484-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206569" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/analysis ; Binding Sites ; Cell Line ; Cell Transformation, Viral ; Deltaretrovirus/genetics/*physiology ; Epitopes/metabolism ; Genes, Viral ; Humans ; *Lymphocyte Activation ; Phenotype ; T-Lymphocytes/*immunology/microbiology ; Tetanus Toxoid/immunology ; Viral Proteins/biosynthesis
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    Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-12
    Description: A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitsuya, H -- Popovic, M -- Yarchoan, R -- Matsushita, S -- Gallo, R C -- Broder, S -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):172-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6091268" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Survival/drug effects ; Clone Cells ; Cytopathogenic Effect, Viral/drug effects ; Deltaretrovirus/*drug effects/physiology ; Humans ; Suramin/*pharmacology ; T-Lymphocytes/*microbiology/physiology ; T-Lymphocytes, Helper-Inducer/*microbiology/physiology ; Virus Replication/drug effects
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    High-resolution proton nuclear magnetic resonance analysis of metastatic cancer cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-21
    Description: High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio of cholesterol to phospholipid and an increased amount of plasma membrane-bound cholesterol ester. High-resolution NMR spectroscopy could therefore be used to assess the metastatic potential of primary tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mountford, C E -- Wright, L C -- Holmes, K T -- Mackinnon, W B -- Gregory, P -- Fox, R M -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1415-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505699" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/analysis ; Cholesterol Esters/analysis ; *Magnetic Resonance Spectroscopy ; Membrane Lipids/analysis ; Neoplasm Metastasis/*etiology ; Neoplasms, Experimental/*analysis/pathology ; Rats ; Rats, Inbred Strains ; Triglycerides/analysis
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    Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-09
    Description: Antisera to synthetic peptides representing sequences of both chains of platelet-derived growth factor (PDGF) were used to structurally analyze PDGF isolated from outdated human platelets and PDGF-like proteins in normal and transformed cells. Most PDGF isolated from platelets did not contain the carboxyl portion of PDGF-2 in contrast to p20sis, the major form of p28sis detected in simian sarcoma virus-transformed cells. In addition, higher molecular weight forms of molecules containing PDGF-1 and PDGF-2 sequences were detected in all cell lines tested. These lines were heterogeneous with respect to species, cell type, and transforming agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niman, H L -- Houghten, R A -- Bowen-Pope, D F -- CA 25803/CA/NCI NIH HHS/ -- HL 18645/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 9;226(4675):701-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494905" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Electrophoresis, Polyacrylamide Gel ; Humans ; Immune Sera/immunology ; Molecular Weight ; Platelet-Derived Growth Factor/*immunology/isolation & purification ; Rats
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  • 73
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    Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: Amplification is one of the mechanisms by which cellular oncogenes may be altered in their function, possibly leading to neoplastic transformation. The oncogenes c-myc, c- abl , and c-Ki-ras are amplified in several different human neoplasias. The oncogene c-myb, which is specifically expressed and regulated in hematopoietic cells, was found to be amplified in cell lines ML-1, ML-2, and ML-3, which were separately cultured from cells of a patient with acute myelogenous leukemia (AML). A five- to tenfold amplification was correlated with high levels of expression of normal size c-myb messenger RNA and with chromosomal abnormalities in the region 6q22 -24, where the c-myb locus is normally located. Amplification and cytogenetic abnormalities were detected in DNA's from primary and secondary cultures of ML cells, suggesting that they may have contributed to leukemogenesis. The similar AML cell lines HL-60 and ML's contain different amplified oncogenes: c-myc and c-myb, respectively. Alternative activation of structurally and possibly functionally similar oncogenes may distinguish--at the pathogenetic level--phenotypically similar tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelicci, P G -- Lanfrancone, L -- Brathwaite, M D -- Wolman, S R -- Dalla-Favera, R -- P30 CA-16087/CA/NCI NIH HHS/ -- RR 05399/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1117-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585957" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; DNA, Neoplasm/genetics ; *Gene Amplification ; Humans ; Karyotyping ; Leukemia, Myeloid, Acute/*genetics ; Nucleic Acid Hybridization ; *Oncogenes
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    Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: A cell system was developed for the reproducible detection of human T-lymphotropic retroviruses (HTLV family) from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS). The cells are specific clones from a permissive human neoplastic T-cell line. Some of the clones permanently grow and continuously produce large amounts of virus after infection with cytopathic (HTLV-III) variants of these viruses. One cytopathic effect of HTLV-III in this system is the arrangement of multiple nuclei in a characteristic ring formation in giant cells of the infected T-cell population. These structures can be used as an indicator to detect HTLV-III in clinical specimens. This system opens the way to the routine detection of HTLV-III and related cytopathic variants of HTLV in patients with AIDS or pre-AIDS and in healthy carriers, and it provides large amounts of virus for detailed molecular and immunological analyses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popovic, M -- Sarngadharan, M G -- Read, E -- Gallo, R C -- New York, N.Y. -- Science. 1984 May 4;224(4648):497-500.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200935" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Cell Division ; Cell Line ; Cell Nucleus/ultrastructure ; Cell Survival ; Clone Cells/microbiology ; Cytopathogenic Effect, Viral ; Deltaretrovirus/growth & development/*isolation & purification ; Genetic Variation ; Humans ; RNA-Directed DNA Polymerase/metabolism ; T-Lymphocytes/microbiology ; Virus Cultivation
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-08
    Description: The involvement of plasma fibronectin in phagocytosis of bacteria was investigated by testing the binding of fibronectin to several species of bacteria and by evaluating the ability of fibronectin to promote binding and endocytosis of two species of these bacteria by phagocytic cells. Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Water, L -- Destree, A T -- Hynes, R O -- R01CA17007/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338594" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*metabolism ; Cell Line ; Cricetinae ; Endocytosis ; Fibronectins/*metabolism ; Humans ; Macrophages/physiology ; Mice ; Opsonin Proteins/physiology ; *Phagocytosis ; Rabbits ; Salmonella typhimurium/metabolism ; Sepsis/immunology ; Staphylococcus aureus/metabolism
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    Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: Four surface antigens previously recognized only in macrophages are present on human small cell lung carcinoma cells and tumors. Cancerous cells may arise from macrophage precursors in bone marrow, and these precursors migrate to lung to participate in the repair of damaged tissue produced by continuous heavy smoking. The characteristic presence of neuropeptides such as bombesin in small cell carcinoma, when considered along with these findings, presents new possibilities for the role of such peptides in nervous, endocrine, and immune system function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruff, M R -- Pert, C B -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1034-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089338" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Neoplasm/*analysis ; Antigens, Surface/*analysis ; Carcinoma, Small Cell/etiology/*immunology/pathology ; Cell Line ; Cell Transformation, Neoplastic ; *Hematopoietic Stem Cells ; Humans ; Lung Neoplasms/etiology/*immunology/pathology ; Macrophages/*immunology ; Monocytes/pathology ; Smoking
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 77
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    Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-05
    Description: The human T-cell leukemia viruses HTLV-I and HTLV-II are unique among the transforming retroviruses of vertebrates in their ability to transform human T cells in vitro and in their close association with human malignancies (T-cell lymphomas and leukemia). Their genomes are relatively simple, containing the genes gag, pol, env, and a 3' region termed "X." This 3' region may be responsible for the transforming potential of the viruses. The existence of proteins encoded by the 3' region has been postulated on the basis of multiple open reading frames. In the present study this region is shown to contain a gene encoding a protein of 40 kilodaltons in HTLV-I and 37 kilodaltons in HTLV-II. It is proposed that these proteins be called, respectively, p40xI and p37xII.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slamon, D J -- Shimotohno, K -- Cline, M J -- Golde, D W -- Chen, I S -- CA 16042/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- RR 00865/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):61-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089351" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; B-Lymphocytes/microbiology ; Cell Line ; *Cell Transformation, Viral ; Deltaretrovirus/analysis/*genetics/physiology ; *Genes, Viral ; Humans ; Immune Sera ; Molecular Weight ; T-Lymphocytes/*microbiology ; Trans-Activators ; Viral Proteins/genetics/immunology/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 78
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    Hemoglobin switching: a cellular model (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alter, B P -- Goff, S C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):647-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; Clone Cells/metabolism ; Dimethyl Sulfoxide/pharmacology ; Globins/*biosynthesis/genetics ; Leukemia, Erythroblastic, Acute/metabolism ; Mice
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  • 79
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    Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Backer, J M -- Weinstein, I B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):297-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770466" target="_blank"〉PubMed〈/a〉
    Keywords: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide ; Animals ; Benzopyrenes/*metabolism ; Cell Line ; Cell Nucleus/metabolism ; DNA Replication/drug effects ; DNA, Mitochondrial/*metabolism ; Embryo, Mammalian ; Embryo, Nonmammalian ; L Cells (Cell Line) ; Liposomes
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    The case of the unmentioned malignancy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1229-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434022" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Survival/radiation effects ; Cell Transformation, Neoplastic/radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Humans ; Neoplasms, Radiation-Induced/*etiology
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  • 81
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    Vertebrate cells express protozoan antigen after hybridization (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-11
    Description: Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol. Hybrid cells were selected on the basis of T. cruzi DNA complementation of biochemical deficiencies in the vertebrate cells. Some clones of the hybrid cells expressed T. cruzi-specific antigen. It might be possible to use selected antigens obtained from the hybrids as vaccines for immunodiagnosis or for elucidation of the pathogenesis of Chagas' disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crane, M S -- Dvorak, J A -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):194-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6987737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antigens/isolation & purification ; *Cell Fusion ; Cell Line ; Clone Cells ; Hybrid Cells/*immunology ; Hybridization, Genetic ; Mammals ; Polyethylene Glycols ; Trypanosoma cruzi/genetics/*immunology
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  • 82
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    Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: A biologically active rhodamine conjugate of thyrotropin binds at 4 degrees C to diffusely distributed membrane thyrotropin receptors which patch and become endocytosed into thyroid cells in a temperature-sensitive process. When the cells are first incubated with 8-bromo-cyclic adenosine monophosphate at 37 degrees C, the conjugate also binds to clustered receptors at 4 degrees C. Furthermore, 8-bromo-cyclic adenosine monophosphate reduces the amount of adenosine 3',5'-monophosphate (cyclic AMP) induced by thyrotropin. Hence, increased intracellular cyclic AMP induces receptor patching and reduces the concentration of cyclic AMP normally induced by thyrotropin. This suggests that cyclic AMP acts both as the second messenger of thyrotropin and also as the regulator of the level of thyrotropin receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Avivi, A -- Tramontano, D -- Ambesi-Impiombato, F S -- Schlessinger, J -- CA-25820/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272396" target="_blank"〉PubMed〈/a〉
    Keywords: 8-Bromo Cyclic Adenosine Monophosphate ; Animals ; Cell Line ; Cell Membrane/drug effects/metabolism ; Cyclic AMP/*analogs & derivatives/*metabolism/pharmacology ; Rats ; Receptors, Cell Surface/drug effects/*metabolism ; Receptors, Thyrotropin ; Thyroid Gland/metabolism ; Thyrotropin/*metabolism/pharmacology
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  • 83
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    Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-06
    Description: The etiologic agent of Korean hemorrhagic fever has been propagated in a human cultured cell line derived from a carcinoma of the lung. The cells, described as type II, alveolar epithelial, support replication of the agent and successive passages. Antigen of the Korean hemorrhagic fever agent is readily detected in infected cells by means of direct or indirect fluorescent antibody techniques. Previous attempts to propagate this agent in vitro had been unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉French, G R -- Foulke, R S -- Brand, O A -- Eddy, G A -- Lee, H W -- Lee, P W -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1046-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6110243" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Viral/analysis ; Cell Line ; Hantavirus/*growth & development/immunology ; Hemorrhagic Fever with Renal Syndrome/*microbiology ; Humans ; Pulmonary Alveoli/microbiology ; RNA Viruses/*growth & development
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    Somatic cell hybrids from frog lymphocytes and mouse myeloma cells (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-05-29
    Description: Stable somatic cell hybrids were obtained by fusing Xenopus lymphocytes with mouse myeloma cells. These hybrids contained one to four Xenopus chromosomes and expressed Xenopus gene products, one of which was a lymphocyte membrane protein of 85,000 daltons precipitated by a monoclonal antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hengartner, H -- Du Pasquier, L -- New York, N.Y. -- Science. 1981 May 29;212(4498):1034-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Antibodies, Monoclonal ; Cell Line ; Clone Cells ; Genes ; Hybrid Cells/*physiology ; Lymphocytes/*physiology ; Membrane Proteins/biosynthesis ; Mice ; Molecular Weight ; Neoplasms, Experimental/physiopathology ; Plasmacytoma/*physiopathology ; Xenopus
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  • 85
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    Purified reduced nicotinamide adenine dinucleotide: responses to lactate dehydrogenase isozymes from three cell sources (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinucleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purified from rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not account for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The results suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, A E -- Weiss, E R -- Byrne, S T -- El-Torkey, N M -- Margolis, S A -- New York, N.Y. -- Science. 1981 May 1;212(4494):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/enzymology ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Liver Neoplasms, Experimental/enzymology ; NAD/analysis/*metabolism ; Rabbits ; Rats
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  • 86
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    Owl monkey cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, S J -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1214.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus ; Cell Line ; Hodgkin Disease/*pathology ; Humans ; Phenotype
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  • 87
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    Anomalous patterns in cultured cell monolayers (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, E M -- Flunk, L J -- Mullin, J M -- Kleinzeller, A -- 2 T32 GM07229-07/GM/NIGMS NIH HHS/ -- AM 12619-13/AM/NIADDK NIH HHS/ -- HL07027-07/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7048529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Count ; Cell Line ; Cells, Cultured/*cytology ; Cricetinae ; *Cytological Techniques ; Dogs ; Mice ; Temperature
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  • 88
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    Migration inhibition of endothelial cells by lymphokine-containing supernatants (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-15
    Description: Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M C -- Picciano, P T -- Douglas, W J -- Yoshida, T -- Kreutzer, D L -- Cohen, S -- AI-12477/AI/NIAID NIH HHS/ -- HL-25015/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797069" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Migration Inhibition ; Cell Movement/drug effects ; Endothelium/cytology/*drug effects ; Humans ; Leukocyte Migration-Inhibitory Factors/pharmacology ; Lymphokines/*pharmacology ; Macrophages/drug effects ; Mast-Cell Sarcoma/physiopathology
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  • 89
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    Coupling of histone and DNA synthesis in the somatic cell cycle (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-01
    Description: The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Delegeane, A M -- Lee, A S -- 2S07RR05356/RR/NCRR NIH HHS/ -- CA27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cricetinae ; DNA/biosynthesis ; *DNA Replication ; Histones/*biosynthesis ; Mutation
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  • 90
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    Biological diversity in metastatic neoplasms: origins and implications (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-10
    Description: Whether neoplasms are unicellular or multicellular in their origin, the process of tumor evolution and progression can rapidly generate biological diversity. Metastases result from the survival and proliferation of specialized subpopulations of cells within the parent tumor. Metastases may have a clonal origin and different metastases may develop from different progenitor cells. However, as with the primary tumor, the origin of metastases is unimportant since the process of tumor evolution and progression can generate biological diversity within and among different metastatic foci.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- Hart, I R -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):998-1003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112116" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/pathology ; Clone Cells ; Humans ; Immunity ; Melanoma/genetics/pathology ; Mice ; Mice, Inbred Strains ; Mutation ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology ; Phenotype ; Skin Neoplasms/genetics/pathology
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  • 91
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    Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavelle, D -- Ostro, M J -- Giacomoni, D -- GM 27935/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Escherichia coli ; Kinetics ; *Liposomes ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Plasmacytoma/*metabolism ; RNA, Bacterial/metabolism ; RNA, Ribosomal/*metabolism ; Saccharomyces cerevisiae ; Species Specificity
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  • 92
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    Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-22
    Description: A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, K M -- Goldberger, G -- Colten, H R -- Aden, D P -- Knowles, B B -- AM 16392/AM/NIADDK NIH HHS/ -- CA 18470/CA/NCI NIH HHS/ -- CA 25875/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):399-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7199205" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Complement C3/*biosynthesis ; Humans ; Liver Neoplasms, Experimental/*metabolism ; Macromolecular Substances ; Molecular Weight ; Protein Precursors/metabolism
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  • 93
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    Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: Inhibiting protein synthesis by incubating C6-2B rat astrocytoma cells with cycloheximide or emetine for periods up to 24 hours caused a progressive decrease in the accumulation of adenosine 3',5'-monophosphate (cyclic AMP) when the cells were challenged for 30 minutes with 100 microM forskolin. In contrast, cholera toxin-stimulated (6 nM, 3 hours) cyclic AMP accumulation was not diminished in cycloheximide-treated cells, and cyclic AMP was only minimally diminished in response to a 30-minute challenge with 10 microM (-)-isoproterenol. These experiments suggest the presence of a previously unrecognized cyclase component, which is essential for forskolin-stimulated cyclic AMP accumulation and has a shorter half-life than the beta-adrenergic receptor, the guanine nucleotide regulatory proteins, or the cyclase catalytic component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooker, G -- Pedone, C -- Barovsky, K -- HL 06330/HL/NHLBI NIH HHS/ -- HL 28940/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1169-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6190226" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytoma/metabolism ; Cell Line ; Cholera Toxin/pharmacology ; Colforsin ; Cyclic AMP/*biosynthesis/physiology ; Cycloheximide/pharmacology ; Dichlororibofuranosylbenzimidazole/pharmacology ; Diterpenes/*pharmacology ; Emetine/pharmacology ; Isoproterenol/pharmacology ; *Protein Biosynthesis ; RNA/biosynthesis ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Ethanol modulation of opiate receptors in cultured neural cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charness, M E -- Gordon, A S -- Diamond, I -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Ethanol/*pharmacology ; Glioma ; Hybrid Cells ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Rats ; Receptors, Opioid/*drug effects/metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eva, A -- Aaronson, S A -- New York, N.Y. -- Science. 1983 May 27;220(4600):955-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302839" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; DNA Restriction Enzymes ; DNA, Neoplasm/genetics ; Fibrosarcoma/chemically induced/*genetics ; Humans ; Methylcholanthrene/*pharmacology ; Mice ; Oncogenes/*drug effects ; Retroviridae/genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Shark cartilage contains inhibitors of tumor angiogenesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-16
    Description: Shark cartilage contains a substance that strongly inhibits the growth of new blood vessels toward solid tumors, thereby restricting tumor growth. The abundance of this factor in shark cartilage, in contrast to cartilage from mammalian sources, may make sharks an ideal source of the inhibitor and may help to explain the rarity of neoplasms in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, A -- Langer, R -- EY04002/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6193581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cartilage/*physiology ; Cell Line ; Cornea ; Neoplasms/*blood supply ; *Neovascularization, Pathologic ; Rabbits ; Sharks
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-23
    Description: The plasma membranes of hamster, mouse, and human tumor cell lines that display multiple resistance to drugs were examined by gel electrophoresis and immunoblotting. In every case, increased expression of a 170,000-dalton surface antigen was found to be correlated with multidrug resistance. This membrane component is of identical molecular size and shares some immunogenic homology with the previously characterized P-glycoprotein of colchicine-resistant Chinese hamster ovary cells. This finding may have application to cancer therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kartner, N -- Riordan, J R -- Ling, V -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1285-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6137059" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane Permeability ; *Drug Resistance ; Glycoproteins/immunology/*physiology ; Membrane Proteins/*physiology ; Molecular Weight ; P-Glycoprotein
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Dissections and reconstructions of genes and chromosomes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, P -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):296-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosomes/*physiology/ultrastructure ; DNA Restriction Enzymes ; DNA, Recombinant ; DNA, Viral/genetics ; *Genes ; Histones ; Humans ; Plasmids ; RNA, Messenger/genetics ; Simian virus 40/genetics ; Transduction, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Hydra mesoglea: a model for investigating epithelial cell--basement membrane interactions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-16
    Description: Isolated hydra mesoglea served as a suitable substrate for the attachment and spreading of hydra cells in vitro, irrespective of the species tested. Hydra cells did not attach and spread on substrates typically used for culturing mammalian cells. Mammalian and Drosophila cells attached and spread on plastic culture dishes but not on isolated mesoglea. Xenopus epithelial cells spread on both plastic and mesoglea. Because of the similarities of hydra mesoglea to vertebrate basement membranes, suggestions are offered for using mesoglea to study the interactions of epithelial cells with their basement membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Day, R M -- Lenhoff, H M -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):291-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444468" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/physiology ; Biological Evolution ; Cell Adhesion ; Cell Line ; Epithelial Cells ; Extracellular Space/physiology ; Hydra/*cytology ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kazmers, I S -- Mitchell, B S -- Dadonna, P E -- Wotring, L L -- Townsend, L B -- Kelley, W N -- AM 19045/AM/NIADDK NIH HHS/ -- CA 26032/CA/NCI NIH HHS/ -- CA 26284/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1137-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795718" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/enzymology ; Cell Line ; Deoxyguanosine/pharmacology ; Guanosine/*analogs & derivatives/pharmacology ; Humans ; Kinetics ; Pentosyltransferases/*antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/*antagonists & inhibitors ; T-Lymphocytes/drug effects/*enzymology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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