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  • BIOSCIENCES  (1,698)
  • 1970-1974  (1,698)
  • 1
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    Space and man (1974)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The effects of man's entry into space on changes in economics and technology, politics and law, science, philosophy, and art are considered. A single world economy, extracting from the natural resources of the moon and other cosmic bodies raw materials and energy, will avoid terrestrial limitations and improve society by eliminating the inequalities of economic and social status. However, a spacecraft for interplanetary travel require thermonuclear engines that achieve an escape velocity of 0.1 times the speed of light in order to allow an astronaut stellar expedition corresponding to the active life of a single generation.
    Keywords: BIOSCIENCES
    Type: Inhabited Space, Pt. 2 (NASA-TT-F-820); p 128-134
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  • 2
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    Detection of life in space (1974)
    In:  CASI
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    Publication Date: 2006-01-11
    Description: The selection of spacecraft experiments and equipment to detect extraterrestrial life outside earth centers on observations of chemical compounds similar to amino acids and proteins, on signs of metabolism in the form of nutrient absorption, and life form impressions in fossiles or signs of civilization.
    Keywords: BIOSCIENCES
    Type: Inhabited Space, Pt. 2 (NASA-TT-F-820; p 42-52
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  • 3
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    Space psychology (1974)
    In:  CASI
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    Publication Date: 2006-01-11
    Description: Psychological selection of astronauts considers mental responses and adaptation to the following space flight stress factors: (1) confinement in a small space; (2) changes in three dimensional orientation; (3) effects of altered gravity and weightlessness; (4) decrease in afferent nerve pulses; (5) a sensation of novelty and danger; and (6) a sense of separation from earth.
    Keywords: BIOSCIENCES
    Type: Inhabited Space, Pt. 2 (NASA-TT-F-820); p 29-41
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  • 4
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    Life in space (1974)
    In:  CASI
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    Publication Date: 2006-01-11
    Description: Biotechnological aspects of manned space flight are reviewed and the basic biological problems of training and sustaining man in interplanetary flights are elaborated.
    Keywords: BIOSCIENCES
    Type: Inhabited Space, Pt. 2 (NASA-TT-F-820); p 17-28
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  • 5
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    Alterations in left ventricular volumes induced by Valsalva manoeuvre (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Five patients were studied with left ventriculography during different phases of the Valsalva manoeuvre. Small doses of contrast medium allowed adequate repetitive visualization of the left ventricle for volume calculation. During strain phase, the volume of the left ventricle decreased by nearly 50 per cent in each case, and stroke volume and cardiac output also dropped strikingly. Release of straining was attended by a sharp rebound of left ventricular volume to control levels, with a transient surge of increased cardiac output 42 per cent above that of the resting state.
    Keywords: BIOSCIENCES
    Type: British Heart Journal; 36; July 197
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  • 6
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    Apollo space crew cardiovascular evaluations (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Cardiovascular responses associated with pre- and postflight orthostatic tolerance evaluations of Apollo crewmen are presented with a brief historical survey and a discussion of their implications for future manned space flight. Heart rates were increased while systolic and pulse pressures were decreased during the immediate postflight orthostatic evaluation. A postflight elevation in resting heart rate was a less frequent finding.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Aug. 197
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  • 7
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    Recovery of medically important microorganisms from Apollo astronauts (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Microbiological samples were obtained from the crewmembers of the Apollo 13, 14, 15, 16, and 17 spaceflights. These specimens were analyzed for the presence of medically important microorganisms with Staphylococcus aureus, Pseudomonas aeruginosa, Tricophyton mentagrophytes, Tricophyton rubrum, and Candida albicans being discussed in detail. Preflight isolation of crewmembers was found to coincide with a complete absence of inflight disease events and is recommended for future spaceflights. No autoinfection response (microbial shock) occurred after any of the reported spaceflights.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Aug. 197
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  • 8
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    Alteration of pituitary-adrenal dynamics induced by a water deprivation regimen (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Experiments are described which were designed to assess the degree of adaptation that occurs in rats chronically exposed to the stress of a water-deprivation regimen and to determine if that adaptation represents a normalization of the hypothalamic-pituitary-adrenal axis. There were no significant differences in mean corticosterone concentrations among control nondeprived rats 1, 4, and 8 weeks after the start of the experiment. The water-deprived rats, however, had significantly elevated plasma steroids 1 and 4 weeks after the onset of deprivation as compared to controls, but not after 8 weeks. Thus, there was a significant decrease in mean plasma corticosterone levels during water deprivation from 1 week to 8 weeks.
    Keywords: BIOSCIENCES
    Type: Physiology and Behavior; 12; 1974
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  • 9
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    Effects of simulated weightlessness on responses of untrained men to +Gz acceleration (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: This study documents bedrest-induced metabolic and physiologic changes in six untrained men exposed, following a two-week period of simulated weightlessness, to possible +Gz acceleration profiles anticipated for Space Shuttle vehicle travel. All subjects demonstrated decreased +Gz tolerance following simulated weightlessness. While only one of six subjects could not tolerate the +Gz profile in the control phase of the study, three of the six could not complete the postbed-rest study. The use of an inflated standard Air Force cutaway G-suit improved +Gz tolerance in all subjects, but two of six subjects still failed to complete the profile. These findings are discussed in reference to the selection of untrained humans for Space Shuttle vehicle travel.
    Keywords: BIOSCIENCES
    Type: Journal of Applied Physiology; 36; June 197
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  • 10
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    Determination of left ventricular size and shape (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Significant advances have occurred over the past 15 years in the ability to measure ventricular dimensions. Angiocardiography still remains the most reliable method for overall determination of chamber size and shape and serves as a standard for calibration or comparison for newer methods. Improvements in the use of radiographic methods over the next few years are anticipated with more extensive use of multiplane studies associated with repeated injections of improved contrast materials that produce fewer physiological effects or with substances that adhere to the endocardial surfaces. It is also anticipated that existing methods for automatically obtaining dimensional information from X rays will be continued and improved.
    Keywords: BIOSCIENCES
    Type: Circulation Research; 34; Jan. 197
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  • 11
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    Serotonin and pituitary-adrenal function (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: An investigation is conducted to evaluate the response of the pituitary-adrenal system to a stress stimulus in the rat. In the investigation brain serotonin synthesis was inhibited with p-chlorophenylalanine. In other tests the concentration of serotonin was enhanced with precursors such as tryptophan or 5-hydroxytryptophan. On the basis of the results obtained in the study it is speculated that in some disease states there is a defect in serotonergic neuronal processes which impairs pituitary-adrenal feedback mechanisms.
    Keywords: BIOSCIENCES
    Type: Nature; 248; Mar. 29
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  • 12
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    Life span and fine structural changes in oxygen-poisoned drosophila melanogaster (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Mar. 197
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  • 13
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    Irregular bilayer structure in vesicles prepared from Halobacterium cutirubrum lipids (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Fluorescent probes were used to study the structure of the cell envelope of Halobacterium cutirubrum, and, in particular, to explore the effect of the heterogeneity of the lipids in this organism on the structure of the bilayers. The fluorescence polarization of perylene was followed in vesicles of unfractionated lipids and polar lipids as a function of temperature in 3.4 M solutions of NaCl, NaNO3, and KSCN, and it was found that vesicles of unfractionated lipids were more perturbed by chaotropic agents than polar lipids. The dependence of the relaxation times of perylene on temperature was studied in cell envelopes and in vesicles prepared from polar lipids, unfractionated lipids, and mixtures of polar and neutral lipids.
    Keywords: BIOSCIENCES
    Type: Biochimica et Biophysica Acta; 356; 1974
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  • 14
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    Human radiation tolerance (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The acute radiation syndrome in man is clinically bounded by death at high dose levels and by the prodromal syndrome of untoward physiological effects at minimal levels of clinically effective exposure. As in lower animals, man experiences principally three acute modes of death from radiation exposure (Bond et al., 1965). These are known collectively as the lethal radiation syndromes: central nervous system death, gastrointestinal death, and hematopoietic death. The effect of multiple exposure on lethality, the effect of multiple exposure on hematopoietic recovery, and quantitative aspects of cell and tissue repair are discussed.
    Keywords: BIOSCIENCES
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  • 15
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    Ultrastructural response of rat lung to 90 days' exposure to oxygen at 450 mm Hg (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Young Sprague-Dawley rats were exposed to 100% oxygen at 450 mm Hg in constant environment capsules for 90 days. Lung tissue examined by electron microscopy revealed a number of changes, many similar to those observed after exposure to oxygen at 760 mm Hg for shorter periods of time. Alterations in vesicle size and number and in mitochondrial matrix and cristae appear in both the endothelial and epithelial cells. Blebbing and rarefication of cytoplasm occur in both cell layers of the alveolo-capillary wall. Also seen are fluid in the basement membrane, platelets in the capillaries, and alveolar fluid and debris. All of these alterations occur at 1 atm exposure. However, after exposure to 450 mm Hg the changes are not as widespread nor as destructive as they are at the higher pressure.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Sept
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  • 16
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    Microbial detection method based on sensing molecular hydrogen (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: An approach involving the measurement of hydrogen evolution by test organisms was used to detect and enumerate various members of the Enterobacteriaceae group. The experimental setup for measuring hydrogen evolution consisted of a test tube containing two electrodes plus broth and organisms. The test tube was kept in a water bath at a temperature of 35 C. It is pointed out that the hydrogen-sensing method, coupled with the pressure transducer technique reported by Wilkins (1974) could be used in various experiments in which gas production by microorganisms is being measured.
    Keywords: BIOSCIENCES
    Type: Applied Microbiology; 27; May 1974
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  • 17
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    Treatment of the external epicondylitis of the humerus with a magnetic field (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The therapeutic effect of a constant and varying magnetic field on epicondylitis of the humerus is studied on ninety patients. Good results are obtained from the treatment (recovery of 80%, considerable improvement in 14.5%). The method is recommended for clinical application.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 191-197
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  • 18
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    Effect of magnetic bracelets on the coagulation and anticoagulation systems of the blood of patients with hypertension (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The data which have been obtained on the influence of magnetic bracelets on the coagulation and anticoagulation systems of the blood indicate that the wearing of magnetic bracelets results in a decrease in the coagulation activity of the blood and an increase in the activity of the anticoagulation system. These changes must be viewed as favorable for patients with cardiovascular pathology.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 167-190
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  • 19
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    Changes in the fibrinogen-fibrin system following a 20-hour exposure of rabbits to a magnetic field (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Prolonged exposure of animals to a constant magnetic field resulted in a sharp increase in the amount of fibrinogen. The addition of EACA to the plasma of experimental rabbits as well as protamine sulfate caused an additional increase in the amount of fibrinogen. A 20-hour exposure was accompanied by phenomena of paralysis of the pelvic limbs and death of some of the animals.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 163-166
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  • 20
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    Influence of a constant magnetic field on the fibrinogen-fibrin system (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The effect of a constant magnetic field with a strength of 2500 oersteds on the fibrinogen-fibrin system was studied in the organism of healthy rabbits with exposure times of 1 and 5 hours. The results obtained indicate disruptions in the stage of conversion of fibrinogen to fibrin and an increase in the amount of fibrinogen.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 157-161
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  • 21
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    Influence of a constant magnetic field on thrombocytes (1974)
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    Publication Date: 2011-08-16
    Description: In an experiment on white mice it was found that a constant electromagnetic field with strength of 250-275 oersteds is biologically active at an exposure of 55 minutes. Qualitative and morphological changes in thrombocytes 1-3 days following exposure reduced their numbers, prolonged blood coagulation time and increased the number of leucocytes.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 141-147
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  • 22
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    The protective effect of a constant magnetic field (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The protective effect of a constant magnetic field sharply reduced spontaneous lysis of E. coli cells when subjected to ultraviolet radiation. A protective effect of a CMF was found in a study of tissue cultures of normally growing cells (kidney epithelium) and cancer cells (cells from a cancer of the larynx). The protective effect of a CMF is also seen in a combined exposure of tissue cultures to X-rays and CMF energy (strength of the CMF was 2000 oersteds with a gradient of 500 oersteds/cm). The data obtained are of interest to experimental oncology (development of new methods of treating malignant tumors).
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 148-156
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  • 23
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    Method of magnetobiological indication in clinical laboratory practice (1974)
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    Publication Date: 2011-08-16
    Description: Data are presented on the use of the method of magnetobiological indication for defining the immunobiological state of patients with very serious diseases. It has been found that the enzymes of a patient react more sensitively to the energy from a magnetic field. It is important that the magnetoreactivity of the enzymes, like the cell forms of the blood in the patients, have a certain relationship to the clinical-nosological forms and the dynamics of the illness of the subject.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 129-140
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  • 24
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    Influence of a constant and variable magnetic field on the coagulation of human blood in vitro and in vivo (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The influence of constant and varying magnetic fields on the coagulation of the blood was studied in experiments performed in vitro and vivo. In the in vitro tests it was found that a constant magnetic field with a strength of 100 or 200 oersteds influences the coagulation of the blood, retarding it in some cases and speeding up the coagulation time in others. In the in vivo studies, both retarding and accelerating effects were likewise observed with respect to the coagulation of the blood, but the nature of the change was a function of the background. A normalizing effect of the magnetic field on the coagulation of the blood was observed.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 124-128
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  • 25
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    Change in fibrinolytic activity under the influence of a constant magnetic field (1974)
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    Publication Date: 2011-08-16
    Description: The fibrinolytic activity of plasma changes under the influence of a constant magnetic field (CMF) with a strength of 250 or 2500 oersteds. CMF shows a tendency toward normalization of fibrinolytic processes in the presence of pathological disturbances in fibrinolysis activation.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 117-123
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  • 26
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    Change in blood coagulation indices as a function of the incubation period of plasma in a constant magnetic field (1974)
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    Publication Date: 2011-08-16
    Description: The influence of a constant magnetic field (CMF) with a strength of 250 and 2500 oersteds on the recalcification reaction and the tolerance of plasma to heparin was studied as a function of the exposure time of the plasma to the CMF. The maximum and reliable change in the activation of the coagulatory system of the blood was observed after a 20-hour incubation of the plasma in a CMF. As the exposure time increased, the recalcification reaction changed insigificantly; the difference between the mean arithmetic of the experiment and control values was not statistically reliable. The tolerance of the plasma to heparin as a function of the exposure time to the CMF of the plasma was considerably modified, an was statistically reliable.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, aeronomy and Solar Phys. (NASA-TT-F-15862); p 109-116
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  • 27
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    Repeated action of a constant magnetic field on the blood coagulation system in artificially produced anemia (1974)
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    Publication Date: 2011-08-16
    Description: Changes are discussed in the coagulatory system of the blood in rabbits under the influence of a constant magnetic field of an intensity of 2500 oersteds against the background of artificially induced anemia. Reversibility of the changes produced and the presence of the adaptational effect are noted. Taking all this into consideration, the changes involving the coagulatory system of the blood which arise under the influence of a constant magnetic field may be considered to have a nerve-reflex nature.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 97-108
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  • 28
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    The influence of a constant magnetic field on the coagulatory system of the blood in an experiment (1974)
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    Publication Date: 2011-08-16
    Description: The influence of a constant magnetic field with a strength of 2500 oersteds on the coagulatory system of the blood in rabbits was studied; the animals were subjected to this field for one and five hours. The magnetic field acts on the coagulatory system of the blood after only one hour exposure. Repeated 5-hour exposures cause activation of the anticoagulatory system in the blood and causes distinctive effects on the subsequent changes in the coagulatory system of the blood. It is quite likely that in this instance the adaptational properties of the organism make themselves felt.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 82-96
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  • 29
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    Effect of a magnetic field of extremely low intensity on the coagulatory system of the blood (1974)
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    Publication Date: 2011-08-16
    Description: The influence of a magnetic field of 10,000 gamma on the conditions of the coagulatory system of rabbits was studied. The results from a number of experiments indicate that the action of a very weak magnetic field produces an increase in the coagulatory activity of the blood.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 73-81
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  • 30
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    Reactions of the nervous system to magnetic fields (1974)
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    Publication Date: 2011-08-16
    Description: This magnetobiological survey considers sensory, nervous, stress and genetic effects of magnetic fields on man and animals. It is shown that the nervous system plays an important role in the reactions of the organism to magnetic fields; the final biological effect is a function of the strength of the magnetic fields, the gradient, direction of the lines of force, duration and location of the action, and the functional status of the organism.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 59-72
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  • 31
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    Results of comparison of the dynamics of the epidemic process with changes in the planetary index of magnetic disturbance (1974)
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    Publication Date: 2011-08-16
    Description: Possible pathways for the action of factors related to solar activity and its magnetic effects on the epidemic process are discussed.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 31-38
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  • 32
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    Statistical evaluation of the significance of the influence of abrupt changes in solar activity on the dynamics of the epidemic process (1974)
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    Publication Date: 2011-08-16
    Description: Statistical evaluations of the significance of the relationship of abrupt changes in solar activity and discontinuities in the multi-year pattern of an epidemic process are reported. They reliably (with probability of more than 99.9%) show the real nature of this relationship and its great specific weight (about half) in the formation of discontinuities in the multi-year pattern of the processes in question.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 49-58
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  • 33
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    The problem of the periodicity of the epidemic process (1974)
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    Publication Date: 2011-08-16
    Description: An analysis of data from epidemics makes it possible to determine their principal causes, governed by environmental factors (solar activity, etc.) The results of an analysis of the periodicity of the epidemic process in the case of diphtheria are presented which was conducted with the aid of autocorrelation and spectral methods of analysis. Numerical data (annual figures) are used on the dynamics of diphtheria in 50 regions (points) with a total duration of 2,777 years.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 39-48
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  • 34
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    The influence of weather on fibrinolysis and fibrinogenolysis (1974)
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    Publication Date: 2011-08-16
    Description: Analysis of fibrinolysis and fibrinogenolysis indices by month showed an increase in the activity of these processes from winter to summer (1967-1968). At all seasons of the year, fibrinolysis and fibrinogenolysis increase during weather of the cyclonic type with passage of fronts and sharp fluctuations in meteorological factors in the atmosphere.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 24-30
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  • 35
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    Fibrinolysis and fibrinogenolysis on magnetically-active days (1974)
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    Publication Date: 2011-08-16
    Description: On magnetically-active days, activation of fibrinolysis and fibrinogenolysis is observed. The increase in fibrinolysis and fibrinogenolysis begins on the day of the onset of a magnetic storm, reaching a maximum in 24 hours. Activation is higher on days with magnetic storms with a sudden onset and a C index of 1.5-2.0.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 16-20
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  • 36
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    Influence of synoptic processes on fibrinolysis and fibrinogenolysis in healthy persons (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: It is shown that on days with frontal activity in the atmosphere the levels of fibrinolysis and fibrinogenolysis are increased. The reactions of fibrinolysis and fibrinogenolysis to the passage of warm and cold fronts varies with the season of the year.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 20-23
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  • 37
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    Influence of solar activity on fibrinolysis and fibrinogenolysis (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: During periods of high solar activity fibrinolysis and fibrinogenolysis are increased. A direct correlative relationship is established between the indices of fibrinolysis, fibrinogenolysis and solar flares which were recorded two days before the blood was collected for analysis.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 12-15
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  • 38
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    Notes on the concept of normal values employed in clinical practice (1974)
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    Publication Date: 2011-08-16
    Description: The question of the considerable variations in various blood parameters under the influence of changes in environmental factors is discussed. Recommendations are given that so-called normal values should be given special attention. Fibrinolytic and fibrinogenolytic activity studies on the blood in healthy human beings revealed significant differences for individual months and even on specific days. Changes in the activity of fibrinolysis and fibrinogenolysis show a correlation with changes in the meteorological conditions, seasonal variations and changes in solar activity.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 9-11
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  • 39
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    Heliobiology, its development, successes and tasks (1974)
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    Publication Date: 2011-08-16
    Description: Heliobiology studies the influence of changes in solar activity on life. Considered are the influence of periodic solar activity on the development and growth of epidemics, mortality from various diseases, the functional activity of the nervous system, the development of psychic disturbances, the details of the development of microorganisms and many other phenomena in the living world.
    Keywords: BIOSCIENCES
    Type: Studies in Geomagnetism, Aeronomy and Solar Phys. (NASA-TT-F-15862); p 1-8
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  • 40
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    Rhythmic variation in heart rate and respiration rate during space flight - Apollo 15 (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: As part of the operational biomedical monitoring for Apollo manned missions, ECG and respiration rate are telemetered at selected intervals to mission control. The data were collected as part of this monitoring program. These data were evaluated for circadian and ultradian rhythmicity because of their uniqueness. The ability to detect and quantitate biorhythms in living systems during space flight is an important aspect of evaluating hypotheses concerning the underlying mechanisms of these phenomena. Circadian variation in heart rate during space flight is demonstrated here. In analyzing generated time series data it has been found that period discrimination is much better than the theoretical limit.
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  • 41
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    Hydrocortisone and ACTH levels in manned spaceflight (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The plasma hydrocortisone, plasma ACTH, and urinary hydrocortisone values were recorded for each man of the crews of Apollo flights eight through fifteen, 30, 14, and 5 days before flight, immediately after spaceflight recovery, and on future days until the return of most variables to preflight values. The plasma and urinary preflight hydrocortisone values were significantly higher than the postflight values. This result is discussed in terms of three possible explanations: (1) the adrenal-cortical function is suppressed during spaceflight; (2) the activity in flight may amount to stressful exercise, which tests have shown can cause a decrease in plasma adrenocortical hormones; and (3) the in-flight work-rest cycles may be such as to affect the circadian periodicity of the pituitary-adrenal function.
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  • 42
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    Fine structure of tannin accumulations in callus cultures of Pinus elliotti /slash pine/ (1974)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Canadian Journal of Botany; 52; 3, 19; 1974
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  • 43
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    Auditory and visual evoked potentials during hyperoxia (1974)
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    Publication Date: 2011-08-16
    Description: Experimental study of the auditory and visual averaged evoked potentials (AEPs) recorded during hyperoxia, and investigation of the effect of hyperoxia on the so-called contingent negative variation (CNV). No effect of hyperoxia was found on the auditory AEP, the visual AEP, or the CNV. Comparisons with previous studies are discussed.
    Keywords: BIOSCIENCES
    Type: Electroencephalography and Clinical Neurophysiology; 37; Oct. 197
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  • 44
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    Phase relationships between circadian rhythms and the environment in humans during hypokinesis (1974)
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    Publication Date: 2011-08-16
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  • 45
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    The action of ultrasounds on Bezostaia 1 winter wheat grown in sand pots treated with Knop solution (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: The results of 3 years of research are presented concerning the increase in length and weight of the aerial biomass as compared with the underground biomass, as well as the productivity indexes of Bezostaia 1 winter wheat. The experiment involved two varieties, each of them with nine repetitions. Sterile sifted sand treated several times with a Knop solution during the vegetative period was used as a seed bed. The seeds were kept in water for 2 hours before treatment. Biometric and statistical measurements showed significant responses in the treated varieties.
    Keywords: BIOSCIENCES
    Type: the 4th Natl. Conf. on Acoustics, Vol. 2, B (NASA-TT-F-15663); p 244-249
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  • 46
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    New experimental contributions to understanding the effect of ultrasonic irradiation on tomatoes (1974)
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    Publication Date: 2011-08-16
    Description: Irradiation of Aurora 100 tomatoes by a hydrodynamic ultrasonic generator with a frequency of 25 kHz per sec intensifies seed germination and the growth of the plants, causing precosity and increasing the output by 15.63 to 37.65%. The most effective radiation time (between 20 and 40 min) intensifies the phenophases. It causes some increase in output and changes in the chemical compositions of the fruits.
    Keywords: BIOSCIENCES
    Type: The 4th Natl. Conf. on Acoustics, Vol. 2, B (NASA-TT-F-15663); p 238-242
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  • 47
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    Echocardiography of the aortic valve. I - Studies of normal aortic valve, aortic stenosis, aortic regurgitation, and mixed aortic valve disease (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: British Heart Journal; 36; Apr. 197
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  • 48
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    Effect of bioisolation and the intestinal flora of mice upon evaluation of an Apollo diet (1974)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; May 1974
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  • 49
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    Angiotensinase activity of dipeptidyl aminopeptidase I /cathepsin C/ of rat liver (1974)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Journal of Biological Chemistry; 249; Jan. 10
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  • 50
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    Role of gravity in preparative electrophoresis (1974)
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    Publication Date: 2019-01-25
    Description: Electrophoresis has contributed significantly to the methodology of biological sciences, and shows the potential for large scale fractionation of a wide range of medically important substances, including living cells. Gravity plays an important role in the electrophoretic process, and hence the importance of the NASA effort to develop a zero-gravity separation facility as part of its shuttle program. The current state of art in electrophoresis is reviewed with particular emphasis on the role of gravity and the possible use of istachophoresis. This technique utilizes a discontinuous buffer system, and appears to be the only high resolution electrophoretic technique currently available for separation of living cells.
    Keywords: BIOSCIENCES
    Type: Proc. of the 3d Space Processing Symp. on Skylab Results, Vol. 2; p 729-253
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  • 51
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    Quantitative values of blood flow through the human forearm, hand, and finger as functions of temperature (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: A literature search was made to obtain values of human forearm, hand and finger blood flow as functions of environmental temperature. The sources used include both government and laboratory reports and the research presented in the open literature. An attempt was made to review many of the more quantitative noninvasive determinations and to collate the results in such a way as to yield blood flow values for each body segment as continuous functions of temperature. A brief review of the various ways used to measure blood flow is included along with an abstract of each work from which data was taken.
    Keywords: BIOSCIENCES
    Type: NASA-TM-X-62342
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  • 52
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    Circadian, endocrine, and metabolic effects of prolonged bedrest: Two 56-day bedrest studies (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Two bedrest studies of 56 days each have been conducted to evaluate the effects of prolonged bedrest on circadian synchrony and endocrine and metabolic function. Measurements included the pituitary-adrenal, thyroid, parathyroid, insulin-glucose-growth hormones, catecholamine excretion, body temperature, and heart rate. The results indicated that a rigorous regimen of exercise did not prevent the endocrine and metabolic effects of prolonged bedrest. Changes in circadian, endocrine, and metabolic functions in bedrest appear to be due to changes in hydrostatic pressure and lack of postural cues rather than to inactivity, confinement, or the bleeding schedule. Prolonged bedrest, particularly beyond 24 days, resulted in rhythm desynchronization in spite of well regulated light/dark cycles, temperature, humidity, activity, and meal times and meal composition and in increased lability of all endocrine parameter measured. It also resulted in an apparent insensitivity of the glucose response to insulin, of cortisol secretion to ACTH, and of growth hormone secretion to hypoglycemia.
    Keywords: BIOSCIENCES
    Type: NASA-TM-X-3051 , A-5339
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  • 53
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    Enzyme activity in terrestrial soil in relation to exploration of the Martian surface (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Sensitive tests for the detection of extracellular enzyme activity in Martian soil was investigated using simulated Martian soil. Enzyme action at solid-liquid water interfaces and at low humidity were studied, and a kinetic scheme was devised and tested based on the growth of microorganisms and the oxidation of ammonium nitrite.
    Keywords: BIOSCIENCES
    Type: NASA-CR-138587
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  • 54
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    Bone mineral measurement from Apollo experiment M-078 (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Loss of mineral from bone during periods of immobilization, recumbency, or weightlessness is examined. This report describes the instrumentation, technique, and bone mineral changes observed preflight and postflight for the Apollo 14, 15, and 16 missions. The bone mineral changes documented during the Apollo Program are reviewed, and their relevance to future missions is discussed.
    Keywords: BIOSCIENCES
    Type: NASA-TM-X-58110 , JSC-08680
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  • 55
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    Test results on the Viking gas chromatograph-mass spectrometer experiment (1974)
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    Publication Date: 2019-06-27
    Description: The gas chromatograph-mass spectrometer instrument to be utilized in the Viking 1975 Molecular Analysis experiment has undergone preliminary testing in its flight configured version. A synthetic mixture of 24 components as well as a sample of the Murchison meteorite has been used for this purpose. The resulting data not only allowed the identification of most of the organic compounds known to be present, but also revealed the identity of a few unexpected ones. Thus, the sensitivity and reliability of the instrument and data system are satisfactorily demonstrated.
    Keywords: BIOSCIENCES
    Type: Origin of Life; 5; July-Oct
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  • 56
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    Intrathoracic and venous pressure relationships during responses to changes in body position (1974)
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    Publication Date: 2019-06-27
    Description: Simultaneous end-expiratory pressures, referred to midthoracic level, in the superior and abdominal venae cavae, pericardial space, and right and left heart, were recorded without thoracotomy in three anesthetized dogs during sudden changes from supine to vertical head-up or head-down body positions. Intrathoracic and dependent great vein pressures referred to midchest level (sixth thoracic vertebra) decreased and showed simple hydrostatic gradients in either vertical position. However, a discontinuity in the large vein hydrostatic gradient occurred just distal to the superior margin of the thorax in either body position and was resumed again above this level. It is concluded that, just as the cerebrospinal fluid and intraperitoneal pressures minimize the effects of gravitational and inertial forces on the cerebral and visceral circulations, the pericardial and pleural pressures have a similar role for the heart proper.
    Keywords: BIOSCIENCES
    Type: Journal of Applied Physiology; 37; Aug. 197
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  • 57
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    Oxygen effects on mortality of mice infected with Diplococcus pneumoniae (1974)
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    Publication Date: 2019-06-27
    Description: Mice infected by intraperitoneal injection of Diplococcus pneumoniae were held at 1 atm in either hypoxic (12%), hyperoxic (75%), or a normal (21%) oxygen environment. Mortality rates indicated prolongation of survival in hypoxia and shortened survival in hyperoxia. Exposure of mice to the experimental gas mixtures prior to inoculation did not alter the results.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; July 197
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  • 58
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    Regularity in the control of the free-running sleep-wakefulness rhythm (1974)
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    Publication Date: 2019-06-27
    Description: In the present experiment, rigid control over the sleep and wake-up times was employed in an attempt to contain the natural rhythm to a 24-hr cycle. Eight subjects were isolated from all time and social cues for 10 days. They were placed on a rigid schedule of sleep between 11 p.m. and 7 a.m. The results indicate that, for practical purposes, the free-running sleep-wakefulness rhythm can be contained to a 24-hr cycle by rigid control of the sleep portion of the cycle. When part of the control was released by allowing the subjects to sleep beyond 7 a.m., they slept an average of 67 min longer and showed sleep latencies which averaged 73 min. From these data it is concluded that control of the sleep portion of the sleep-wakefulness cycle, particularly control of the wake-up time, is sufficient to contain the free-running sleep-wakefulness rhythm to a 24-hr cycle.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; July 197
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  • 59
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    Parabarosis and experimental infections. II - Body temperatures of small animals; methods of observation and control (1974)
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Mar. 197
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  • 60
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    Parabarosis and experimental infections. III - Susceptibility of mice to influenza virus as modified by chilling and by hyperbaric helium atmosphere. IV - Effect of varying O2 tensions on chlamydial infection in mice and cell cultures (1974)
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Mar. 197
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  • 61
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    The effect of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Cellular response and cell population kinetics were studied during lymphopoiesis in the thymus of the mouse under continuous gamma irradiation using autoradiographic techniques and specific labeling with tritiated thymidine. On the basis of tissue weights, it is concluded that the response of both the thymus and spleen to continuous low dose-rate irradiation is multiphasic. That is, alternating periods of steady state growth, followed by collapse, which in turn is followed by another period of homeostasis. Since there are two populations of lymphocytes - short lived and long-lived, it may be that different phases of steady state growth are mediated by different lymphocytes. The spleen is affected to a greater extent with shorter periods of steady-state growth than exhibited by the thymus.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140114
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  • 62
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    Quantitative ecology and dry-heat resistance of psychrophiles (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Microorganisms capable of growth at 7 C were enumerated and isolated from soil samples from the manufacture area (Denver, Colorado) and assembly area (Cape Kennedy, Florida) of the Viking spacecraft. Temperature requirements were determined for these isolates, and those growing at 3 C, but not at 32 C were designated as obligate psychrophiles in this investigation. These were identified to major generic groups, and the population density of obligate psychrophiles from the various groups was determined. Dry heat D-values were found for those spores that demonstrated growth or survival under a simulated Martian environment.
    Keywords: BIOSCIENCES
    Type: NASA-CR-139667
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  • 63
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    Effects of prolonged acceleration with or without clinostat rotation on seedlings of Arabidopsis thaliana (L.) Heynh (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Three 21-day tests of the effects of chronic centrifugation were carried out on populations of Arabidopsis thaliana. In addition to 1 g the resultant g-forces tested were: 2,4,6,8,16, and 20 g. Observed end points included gross morphological characters such as size of plant organs and, at the other extreme, features of sub-cellular structure and ultrastructure. Plants were grown on banks of clinostats. The acceleration vector was directed either parallel with the plants' axes or transverse to the axes. Plant responses to chronic axial acceleration and to transverse acceleration with clinostated plants were determined. From the data obtained it was possible in some cases: (1) to determine the g-functions of specific plant developmental characters; (2) to extrapolate those functions to the hypothetical value at zero g in order to predict (tentatively) the morphology of a plant grown in space, (3) to describe morphological effects of clinostat rotation, (4) to determine which of those effects was influenced by the prevailing g-force, and (5) to put to direct test the assumption that clinostat rotation nullifies or compensates for the influence of gravity.
    Keywords: BIOSCIENCES
    Type: NASA-CR-139584
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  • 64
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    Utility of ERTS for monitoring the breeding habitat of migratory waterfowl (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Since 1968 the Bureau of Sport Fisheries and Wildlife (BSF&W) and the Environmental Research Institute of Michigan have cooperated on developing applications of remote sensing to the management of migratory waterfowl. Basically, this work has been concerned with (1) the assimilation of data on surface water conditions so that the data can be used as an index of annual waterfowl production, and (2) the collection of data on land use and wetland quality so that a measure of habitat carrying capacity is obtained. To date, efforts have been directed toward utilizing ERTS to monitor surface water conditions. An example of a model used for predicting the annual production of mallards (Anas platyrhynchos) is presented. The data inputs to this model and the potential for acquiring these data using ERTS are described.
    Keywords: BIOSCIENCES
    Type: PAPER-E12 , NASA. Goddard Space Flight Center 3d ERTS-1 Symp., Vol. 1, Sect. B; p 1671-1686
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    An evaluation of the use of ERTS-1 satellite imagery for grizzly bear habitat analysis (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Improved classification and mapping of grizzly habitat will permit better estimates of population density and distribution, and allow accurate evaluation of the potential effects of changes in land use, hunting regulation, and management policies on existing populations. Methods of identifying favorable habitat from ERTS-1 multispectral scanner imagery were investigated and described. This technique could reduce the time and effort required to classify large wilderness areas in the Western United States.
    Keywords: BIOSCIENCES
    Type: PAPER-E11 , NASA. Goddard Space Flight Center 3d ERTS-1 Symp., Vol. 1, Sect. B; p 1653-1670
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  • 66
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    ERTS surveys a 500 km squared locust breeding site in Saudi Arabia (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: From September 1972 to January 1973, ERTS-1 precisely located a 500 sq km area on the Red Sea coastal plain of Saudi Arabia within which the Desert Locust (Schistocerca gregaria, Forsk.) bred successfully and produced many small swarms. Growth of vegetation shown by satellite imagery was confirmed from ground surveys and raingauge data. The experiment demonstrates the feasibility of detecting potential locust breeding sites by satellite, and shows that an operational satellite would be a powerful tool for routine survey of the 3 x 10 to the 7th power sq km invasion area of the Desert Locust in Africa and Asia, as well as of other locust species in the arid and semi-arid tropics.
    Keywords: BIOSCIENCES
    Type: PAPER-A15 , NASA. Goddard Space Flight Center 3d ERTS-1 Symp., Vol. 1, Sect. A; p 233-246
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  • 67
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    Topography of aortic heart valves (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: The cooperative effort towards the development of a tri-leaflet prosthetic heart valve is described. The photogrammetric studies were conducted on silicone rubber molds. Information on data acquisition and data reduction phases is given, and certain accuracy aspects of the project are explained. The various outputs which are discussed include digital models, profiles, and contour maps.
    Keywords: BIOSCIENCES
    Type: NASA-CR-139566 , UILU-ENG-74-2017
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  • 68
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    Correlation of the Hippocampal theta rhythm to changes in hypothalamic temperature (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Warming and cooling the preoptic anterior hypothalamic area in awake, loosely restrained rabbits was found to evoke theta rhythm. This is consistent with previous studies indicating that theta rhythm is a nonspecific response evoked by stimulation of several sensory modalities. Several studies have correlated theta rhythm with alertness. A neural pathway involving the hypothalamus, the hippocampus, the septal area, and the reticular formation is proposed. Thus, a role of this pathway may be to alert the animal to changes in its body temperature.
    Keywords: BIOSCIENCES
    Type: NASA-CR-139526
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  • 69
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    Correlation of hippocampal theta rhythm with changes in cutaneous temperature (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: A possible role for the hippocampus in alerting an animal to changes in cutaneous temperature was examined. Following local warming or cooling of the ears of unanesthetized, loosely restrained rabbits, theta waves (4-7 Hz EEG waves) were recorded from electrodes straddling the hippocampus. The onset of the hippocampal theta rhythm was correlated with changes in cutaneous temperature, an observation consistent with studies indicating that the theta rhythm is a nonspecific response evoked by stimulation of several sensory modalities. Additional data from cats and rabbits were correlated with specific neurons within the hippocampus, namely pyramidal cells. Post stimulus time histograms obtained by excitation of the dorsal fornix were interpreted in terms of excitatory and inhibitory inputs to pyramidal cells. Thus, the theta rhythm, which appears to be evoked by changes in cutaneous temperature, can be related to a specific type of hippocampal neuron which is in turn connected with other areas of the brain involved in temperature regulation.
    Keywords: BIOSCIENCES
    Type: NASA-CR-139527
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    Preparative electrophoresis of living lymphocytes (1974)
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    Publication Date: 2019-06-27
    Description: Vertical liquid columns containing low molecular weight dextran density gradients can be used for preparative lymphocyte electrophoresis on earth, in simulation of 0 gravity conditions. Another method that has been tested at 1 G, is the electrophoresis of lymphocytes in a upward direction in vertical columns. By both methods up to 10 to the 7th power lymphocytes can be separated at one time in a 30 cm glass column of 8 mm inside diameter, at 12 v/cm, in 2 hours. Due to convection and sedimentation problems, the separation at 1 G is less than ideal, but it is expected that at 0 gravity electrophoresis will prove to be a uniquely powerful cell separation tool. The technical feasibility of electrophoresing inert particles at 0 G has been proven earlier, during the flight of Apollo 16.
    Keywords: BIOSCIENCES
    Type: Proc. of the 3d Space Processing Symp. on Skylab Results, Vol. 2; p 755-762
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    Aerospace medicine and biology: A continuing bibliography with indexes, supplement 129, June 1974 (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: This special bibliography lists 280 reports, articles, and other documents introduced into the NASA scientific and technical information system in May 1974.
    Keywords: BIOSCIENCES
    Type: NASA-SP-7011(129)
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  • 72
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    Peripheral visual response time to colored stimuli imaged on the horizontal meridian (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Two male observers were administered a binocular visual response time task to small (45 min arc), flashed, photopic stimuli at four dominant wavelengths (632 nm red; 583 nm yellow; 526 nm green; 464 nm blue) imaged across the horizontal retinal meridian. The stimuli were imaged at 10 deg arc intervals from 80 deg left to 90 deg right of fixation. Testing followed either prior light adaptation or prior dark adaptation. Results indicated that mean response time (RT) varies with stimulus color. RT is faster to yellow than to blue and green and slowest to red. In general, mean RT was found to increase from fovea to periphery for all four colors, with the curve for red stimuli exhibiting the most rapid positive acceleration with increasing angular eccentricity from the fovea. The shape of the RT distribution across the retina was also found to depend upon the state of light or dark adaptation. The findings are related to previous RT research and are discussed in terms of optimizing the color and position of colored displays on instrument panels.
    Keywords: BIOSCIENCES
    Type: NASA-TM-X-3086 , A-5435
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  • 73
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    Respiratory gas exchange of high altitude adapted chick embryos (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Study of gas exchange by embryos from chickens acclimatized to an altitude of 3800 m. The oxygen partial pressure and carbon dioxide partial pressure differences across the egg shell were measured and found to be less than the values previously reported for sea-level eggs by about a factor of two. Further measurements of embryonic oxygen consumption and shell conductivity to oxygen indicated that, compared to eggs at sea level, oxygen consumption was reduced by a factor of 0.58 while conductivity to oxygen was increased only by a factor of 1.07 in the high-altitude eggs. These independent measurements predict the change in oxygen partial pressure across the egg shell of the high-altitude eggs to be only 0.54 times that of sea-level eggs; the directly measured factor was 0.53. The authors conclude that at high altitude, a major adaptation of the chick embryo is a reduced metabolism which decreases the change in oxygen partial pressure across the egg shell since its gas conductivity remains essentially unchanged.
    Keywords: BIOSCIENCES
    Type: Respiration Physiology; 21; July 197
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  • 74
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    The effect of a visual indicator on rate of visual search Evidence for processing control (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Search rates were estimated from response latencies in a visual search task of the type used by Atkinson et al. (1969), in which a subject searches a small set of letters to determine the presence or absence of a predesignated target. Half of the visual displays contained a marker above one of the letters. The marked letter was the only one that had to be checked to determine whether or not the display contained the target. The presence of a marker in a display significantly increased the estimated rate of search, but the data clearly indicated that subjects did not restrict processing to the marked item. Letters in the vicinity of the marker were also processed. These results were interpreted as showing that subjects are able to exercise some degree of control over the search process in this type of task.
    Keywords: BIOSCIENCES
    Type: Perception and Psychophysics; 15; June 197
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  • 75
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    Renal parameter estimates in unrestrained dogs (1974)
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    Publication Date: 2019-06-27
    Description: A mathematical formulation has been developed to describe the hemodynamic parameters of a conceptualized kidney model. The model was developed by considering regional pressure drops and regional storage capacities within the renal vasculature. Estimation of renal artery compliance, pre- and postglomerular resistance, and glomerular filtration pressure is feasible by considering mean levels and time derivatives of abdominal aortic pressure and renal artery flow. Changes in the smooth muscle tone of the renal vessels induced by exogenous angiotensin amide, acetylcholine, and by the anaesthetic agent halothane were estimated by use of the model. By employing totally implanted telemetry, the technique was applied on unrestrained dogs to measure renal resistive and compliant parameters while the dogs were being subjected to obedience training, to avoidance reaction, and to unrestrained caging.
    Keywords: BIOSCIENCES
    Type: Medical and Biological Engineering; 12; July 197
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  • 76
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    The polyuria of paroxysmal atrial tachycardia (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Two patients with paroxysmal atrial fibrillation and an associated polyuria were studied to delineate the mechanism of the increase in urine flow. A striking saluresis was noted in both patients. The increased sodium excretion was probably due to decreased sodium reabsorption, perhaps at proximal tubular nephron sites. This inhibition of sodium reabsorption could explain both the saluresis and some part or all of the polyuria. Re-evaluation of earlier case reports reveals patterns of concomitant salt and water excretion consistent with this mechanism. The saluresis cannot be explained by the previously favored hypothesis of antidiuretic hormone inhibition.
    Keywords: BIOSCIENCES
    Type: Circulation; 50; Sept
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  • 77
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    Glossary of selected chronobiologic terms (1974)
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  • 78
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    Response-produced timeouts under a progressive-ratio schedule with a punished reset option (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: An attempt is made to extend the generality of timeouts from positive reinforcement to more complex performances. Pigeons were provided with three continuously available options. Responses on one key resulted in food reinforcement under a progressive-ratio schedule, which requires a larger number of responses for successive reinforcements; responses on a second key, which were shocked, reset the progressive-ratio schedule to its first step; and responses on a third key produced a 3-min timeout. Some of these conditions have been studied previously (Dardano, 1968, 1973; Findley, 1958). Questions of general interest included the frequency and stability of response-produced timeouts, changes in the properties of the progressive-ratio performance resulting from the occurrence of timeouts, and the similarity of the relationships between timeouts and the reinforced behavior to relationships found under simpler conditions of reinforcement.
    Keywords: BIOSCIENCES
    Type: Journal of the Experimental Analysis of Behavior; 22; July 197
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  • 79
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    Brain catechol synthesis - Control by brain tyrosine concentration (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Brain catechol synthesis was estimated by measuring the rate at which brain dopa levels rose following decarboxylase inhibition. Dopa accumulation was accelerated by tyrosine administration, and decreased by treatments that lowered brain tyrosine concentrations (for example, intraperitoneal tryptophan, leucine, or parachlorophenylalanine). A low dose of phenylalanine elevated brain tyrosine without accelerating dopa synthesis. Our findings raise the possibility that nutritional and endocrine factors might influence brain catecholamine synthesis by controlling the availability of tyrosine.
    Keywords: BIOSCIENCES
    Type: Science; 185; July 12
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  • 80
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    Role of central and peripheral adrenergic mechanisms in neurogenic hypertension produced by brainstem lesions in rat (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: Circulation Research; 34; Mar. 197
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  • 81
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    Systolic and diastolic time intervals in pulsus alternans - Significance of alternating isovolumic relaxation (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Systolic and diastolic time intervals in 14 cardiac patients with pulsus alternans revealed significant alternation of preinjection period (PEP), isovolumic contraction time (IVCT), left ventricular ejection time (LVET), ejection time index (ETI), PEP/LVET, and carotid dD/dt with better functional values in the strong beats. Cycle length, duration of electromechanical systole (EMS) and total diastole, i.e., isovolumic relaxation period (IRP) and diastolic filling period (DFP) occurred in 7 out of 8 patients. These diastolic intervals alternated reciprocally such that the IRP of the strong beats encroached upon the DFP of the next (weak) beats.
    Keywords: BIOSCIENCES
    Type: American Heart Journal; 87; Jan. 197
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  • 82
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    Microbiological aspects of clean room technology as applied to surgery, with special reference to unidirectional airflow systems (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: The microbiological aspects of clean room technology as applied to surgery were reviewed. The following pertinent subject areas were examined: (1) clean room technology per se and its utilization for surgery, (2) microbiological monitoring of the clean room surgical environment, (3) clean rooms and their impact on operating room environmental microbiology, and (4) the effect of the technology on surgical wound infection rates. Conclusions were drawn for each topic investigated.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140176 , JPL-SP-43-7
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  • 83
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    The origin of life in a cosmic context (1974)
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    Publication Date: 2019-06-27
    Description: It is shown that there is at present no aspect of contemporary biology where the contingent can be distinguished from the necessary, or the evolutionary accident from the biological sine qua non; and no amount of terrestrial experimentation alone is likely to make such distinctions possible. Hence, biology suffers from a deadening parochialism, much like the physics of falling bodies before Newton showed that the same laws applied to the motion of apples in England and to the planets about the sun. The deparochialization of biology can only come in the same way and must therefore await the search for extraterrestrial life. It is in this sense that the significance of explorations of the planets and their satellites, asteroids, comets, and the interplanetary medium for the origin of life is assessed.
    Keywords: BIOSCIENCES
    Type: Origins of Life; 5; July-Oct
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  • 84
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    Organic contamination problems in the Viking molecular analysis experiment (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: A principal problem in interpreting the results of an organic analysis of an extraterrestrial sample is that of distinguishing contaminating material from indigenous material when unknown types and amounts of contaminants make their way into the sample being analyzed. An approach to control of sample integrity in the Viking molecular analysis experiment has been devised which it is believed, will eliminate such problems. Basically this involves (1) placing an upper limit on the amount of terrestrial contamination that can be tolerated and still allow scientifically meaningful analysis, (2) identifying the potential sources of contamination and analyzing their relative significance, (3) establishing methods to control these sources, and (4) obtaining complete information on the chemical composition of potential contaminants. Previous experience in the Apollo mission has been of great value in developing the Viking program, perhaps the most important carryover being the recognition of the importance of establishing a comprehensive contamination control program in the early stages of mission planning and hardware design.
    Keywords: BIOSCIENCES
    Type: Origin of Life; 5; July-Oct
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  • 85
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    Inferences from protein and nucleic acid sequences - Early molecular evolution, divergence of kingdoms and rates of change (1974)
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    Publication Date: 2019-06-27
    Description: Description of new sensitive, objective methods for establishing the probable common ancestry of very distantly related sequences and the quantitative evolutionary change which has taken place. These methods are applied to four families of proteins and nucleic acids and evolutionary trees will be derived where possible. Of the three families containing duplications of genetic material, two are nucleic acids: transfer RNA and 5S ribosomal RNA. Both of these structures are functional in the synthesis of coded proteins, and prototypes must have been present in the cell at the inception of the fundamental coding process that all living things share. There are many types of tRNA which recognize the various nucleotide triplets and the 20 amino acids. These types are thought to have arisen as a result of many gene duplications. Relationships among these types are discussed. The 5S ribosomal RNA, presently functional in both eukaryotes and prokaryotes, is very likely descended from an early form incorporating almost a complete duplication of genetic material. The amount of evolution in the various lines can again be compared. The other two families containing duplications are proteins; ferredoxin and cytochrome c.
    Keywords: BIOSCIENCES
    Type: Origin of Life; 5; July-Oct
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  • 86
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    Effects of lower body negative pressure on plasma catecholamine, plasma renin activity and the vectorcardiogram (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: AD-785816 , Aerospace Medicine; 45; Aug. 197
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  • 87
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    Parabarosis and experimental infection. V - Effect of altered oxygen tension on Coxsackie B-1 infection in adult mice (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Aug. 197
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  • 88
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    Comments on papers by Reichert and Wong (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Papers of Reichert and Wong (1971) and Reichert (1972) are referred to as erroneous in stating that in their work with cytochrome c sequences they demonstrated that vertebrates have achieved a higher organized genetic message with a higher fidelity in the DNA-to-protein information processing channel. Arguments are given to contest that statement.
    Keywords: BIOSCIENCES
    Type: Journal of Molecular Evolution; 3; 3, 19; 1974
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  • 89
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    An improved method for echographic detection of left atrial enlargement (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Echographic dimensions of the aortic root and left atrium were compared in 170 patients in order to assess dilation of the left atrium with reference to the relatively nondistensible fibrous aortic root. In 50 patients without cause for left atrial or aortic enlargement, the ratio of left atrial/aortic root dimensions was 0.87 to 1.11. In 80 patients with known cause for left atrial enlargement, the left atrial/aortic root ratio was greater than or equal to 1.17. In 40 patients with isolated valve disease, dilation of both the aortic root and the left atrium resulted in a left atrial/aortic root dimension ratio less than 1.17 in some patients. Despite this consideration, the comparison of left atrial and aortic root dimension appears to be as specific as, and more sensitive than, previously proposed methods for the evaluation of left atrial enlargement.
    Keywords: BIOSCIENCES
    Type: Circulation; 50; July 197
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  • 90
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    Influence of bedrest and hypercapnia upon urinary mineral excretion in man (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Bedrest and hypercapnia affected urinary mineral excretion. An increase in the excretion of magnesium, calcium, and inorganic phosphorus was noted during bedrest. Zinc excretion decreased during hypercapnia; however, this decrease was not significant when the experimental and preexperimental periods were compared. The combined effect of bedrest and hypercapnia was not synergistic for calcium excretion.
    Keywords: BIOSCIENCES
    Type: AD-783157 , Aerospace Medicine; 45; July 197
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  • 91
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    Circadian rhythmometry of mammalian radiosensitivity (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: In the case of human bone marrow, the largest number of mitoses is seen in the evening in diurnally active men, mitotic activity being at a minimum in the morning. The opposite pattern is observed for nocturnal animals such as rats and mice on a regimen of light during the daytime alternating with darkness during the night hours. The entirety of these rhythms plays an important role in the organism's responses to environmental stimuli, including its resistance to potentially harmful agents. Conditions under which circadian rhythms can be observed and validated by inferential statistical means are discussed while emphasizing how artifacts of the laboratory environment can be shown to obscure circadian periodic variations in radiosensitivity.
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  • 92
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    Observations on saccules of rats exposed to long-term hypergravity (1974)
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    Publication Date: 2019-06-27
    Description: The saccules of 15 centrifuged rats and 15 control rats were examined for morphological alterations resulting from long-term exposure to hypergravity. Minimal changes were found confined to the otolithic membrane. They were a slight decrease in the overall volume of otolithic membrane, a redistribution of otoconia in the direction of the gravitational force, and a more pronounced 'accessory' membrane. These changes were interpreted as purely mechanical effects of hypergravity, causing accelerated displacement of otoconia and subsequent entrapment of some of them on inferior portions of the primary otolithic membrane and 'accessory' membrane.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; July 197
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  • 93
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    Sympathetic and parasympathetic components of reflex tachycardia induced by hypotension in conscious dogs with and without heart failure (1974)
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: Cardiovascular Research; 8; Mar. 197
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  • 94
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    Parabarosis and experimental infections. I - Effect of varying O2 tensions on influenza virus infection in mice (1974)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 45; Mar. 197
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  • 95
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    The metabolic and hemodynamic effects of prolonged bed rest in normal subjects (1974)
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    Publication Date: 2019-06-27
    Description: Investigation in six normal subjects of the effects of chronic bed rest on the interrelationships between cardiovascular hemodynamics, catecholamine metabolism, vascular reactivity, renin and aldosterone activity, and electrolyte and fluid balance. Negative sodium and potassium balances and reductions in plasma volume were observed in all subjects, but plasma renin activity and aldosterone secretory rate showed no significant change. Other findings included the observation that major decreases in sodium balance and plasma volume occurred in the early bed rest period and did not correlate closely with the degree of orthostatic intolerance.
    Keywords: BIOSCIENCES
    Type: Circulation; 49; Mar. 197
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  • 96
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    The rapid quantitation of the filamentous blue-green alga plectonema boryanum by the luciferase assay for ATP (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Plectonema boryanum is a filamentous blue green alga. Blue green algae have a procaryotic cellular organization similar to bacteria, but are usually obligate photoautotrophs, obtaining their carbon and energy from photosynthetic mechanism similar to higher plants. This research deals with a comparison of three methods of quantitating filamentous populations: microscopic cell counts, the luciferase assay for ATP and optical density measurements.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140486
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  • 97
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    Research on biophysical evaluation of the human vestibular system (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: The human vestibular function was studied by the combined approach of advanced measurement and mathematical modelling. Fundamental measurements of some physical properties of endolymph and perilymph, combined with nystagmus measurements and fluid mechanical analysis of semicircular canal function furthered the theory of canal mechanical response to angular acceleration, caloric stimulation and relating linear acceleration. The effects of adaptation seen at low frequency angular stimulation were studied and modelled to remove some shortcomings of the torsion pendulum models. Otolith function was also studied experimentally and analytically, leading to a new set of models for subjective orientation. Applications to special problems of space, including the case of rotating spacecraft were investigated and the interaction of visual and vestibular cues and their relation to proprioceptive information was explored relative to postural control.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140063
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  • 98
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    Cassette bacteria detection system (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: The design, fabrication, and testing of an automatic bacteria detection system, with a zero-g capability, based on the filter-capable approach, and intended for monitoring the sterility of regenerated water in spacecraft is discussed. The principle of detection is based on measuring the increase in chemiluminescence produced by the action of bacterial porphyrins on a luminol-hydrogen peroxide mixture. Viable organisms are detected by comparing the signal of an incubated water sample with an unincubated control. High signals for the incubated water sample indicate the presence of viable organisms.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140229 , REPT-1110F
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  • 99
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    Biomedical programs operations plans (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Operational guidelines for the space shuttle life sciences payloads are presented. An operational assessment of the medical experimental altitude test for Skylab, and Skylab life sciences documentation are discussed along with the operations posture and collection of space shuttle operational planning data.
    Keywords: BIOSCIENCES
    Type: NASA-CR-140223
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  • 100
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    Video requirements for remote medical diagnosis (1974)
    In:  CASI
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    Publication Date: 2019-06-27
    Description: Minimal television system requirements for medical telediagnosis were studied. The experiment was conducted with the aid of a simulated telemedicine system. The first step involved making high quality videotape recordings of actual medical examinations conducted by a skilled nurse under the direction of a physician watching on closed circuit television. These recordings formed the baseline for the study. Next, these videotape recordings were electronically degraded to simulate television systems of less than broadcast quality. Finally, the baseline and degraded video recordings were shown (via a statistically randomized procedure) to a large number of physicians who attempted to reach a correct medical diagnosis and to visually recognize key physical signs for each patient. By careful scoring and analysis of the results of these viewings, the pictorial and diagnostic limitations as a function of technical video characteristics were to be defined.
    Keywords: BIOSCIENCES
    Type: NASA-CR-134395
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