ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2022-05-25
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Neurobiology of Aging 47 (2016): 113–126, doi:10.1016/j.neurobiolaging.2016.07.015.
    Description: Misfolded tau proteins are characteristic of tauopathies, but the isoform composition of tau inclusions varies by tauopathy. Using aggregates of the longest tau isoform (containing 4 microtubule-binding repeats and 4-repeat tau), we recently described a direct mechanism of toxicity that involves exposure of the N-terminal phosphatase-activating domain (PAD) in tau, which triggers a signaling pathway that disrupts axonal transport. However, the impact of aggregation on PAD exposure for other tau isoforms was unexplored. Here, results from immunochemical assays indicate that aggregation-induced increases in PAD exposure and oligomerization are common features among all tau isoforms. The extent of PAD exposure and oligomerization was larger for tau aggregates composed of 4-repeat isoforms compared with those made of 3-repeat isoforms. Most important, aggregates of all isoforms exhibited enough PAD exposure to significantly impair axonal transport in the squid axoplasm. We also show that PAD exposure and oligomerization represent common pathological characteristics in multiple tauopathies. Collectively, these results suggest a mechanism of toxicity common to each tau isoform that likely contributes to degeneration in different tauopathies.
    Description: This work was supported by NIH grants R01 AG044372 (Nicholas M. Kanaan), R01 NS082730 (Nicholas M. Kanaan and Scott T. Brady), BrightFocus Foundation (A2013364S, Nicholas M. Kanaan), the Jean P. Schultz Biomedical Research Endowment (Nicholas M. Kanaan), the Secchia Family Foundation (Nicholas M. Kanaan) and NS066942A (Gerardo Morfini).
    Keywords: Tauopathy ; Alzheimer's disease ; Oligomer ; Axon ; Aggregation ; Microtubule-associated protein ; Pathological conformations
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2022-05-25
    Description: © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 116 (2015): 283-302, doi:10.1016/j.dsr2.2014.11.019.
    Description: In this paper, we present, describe, and model the first size-fractionated (0.8–51 µm; 〉51 µm) water-column particulate trace metal results from the US GEOTRACES North Atlantic Zonal Transect in situ pumping survey, with a focus on the lithogenic tracer elements Al, Fe and Ti. This examination of basin-wide, full-depth distributions of particulate elements elucidates many inputs and processes—some for bulk lithogenic material, others element-specific—which are presented via concentration distributions, elemental ratios, size-fractionation dynamics, and steady-state inventories. Key lithogenic inputs from African dust, North American boundary interactions, the Mediterranean outflow, hydrothermal systems, and benthic nepheloid layers are described. Using the refractory lithogenic tracer Ti, we develop a 1-D model for lithogenic particle distributions and test the sensitivities of size-fractionated open-ocean particulate Ti profiles to biotically driven aggregation, disaggregation rates, vertical sinking speeds, and dust input rates. We discuss applications of this lithogenic model to particle cycling in general, and to POC cycling specifically.
    Description: International and US GEOTRACES Offices (OCE-0850963 and OCE-1129603), and fellowship assistance from the Williams College Tyng Fellowship and MIT/WHOI Academic Programs Office to DCO.
    Keywords: Marine particles ; Lithogenic ; Particulate trace metals ; Aluminum ; Iron ; Titanium ; GEOTRACES ; Aeolian dust ; Aggregation ; Disaggregation ; Sinking speed ; Scavenging
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
    Format: application/msword
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...