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  • 1
    ISSN: 0168-1591
    Keywords: Fear ; Handling ; Humans ; Poultry ; Productivity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Peptides 1 (1980), S. 55-57 
    ISSN: 0196-9781
    Keywords: ACTH ; Aging ; Attention ; Cognition ; Humans ; MSH ; Peptide ; Visual retention
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Peptides 5 (1984), S. 319-323 
    ISSN: 0196-9781
    Keywords: Blood flow ; Circulation ; Electromagnetic flowmetry ; Humans ; VIP
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Peptides 10 (1989), S. 489-492 
    ISSN: 0196-9781
    Keywords: Angiotensin II ; Blood ; Humans ; Radioimmunoassay ; Rats ; [des-Leu^1^0]-angiotensin I
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
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  • 5
    ISSN: 0196-9781
    Keywords: Autocrine feedback mechanism ; Cholecystokinin ; Feeding ; Humans ; Radioimmunoassay
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Peptides 4 (1983), S. 451-455 
    ISSN: 0196-9781
    Keywords: Biliary system ; Cat ; Guinea-pig ; Humans ; Mucosa ; Rabbit ; Radioimmunoassay ; Respiratory system ; Skin ; Substance P ; Sympathetic nervous system ; Urinary system
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0921-8734
    Keywords: Aging ; Humans ; Ionizing radiation ; Single cell electrophoresis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0921-8734
    Keywords: Ageing ; Humans ; Skin cells ; Telomeres
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Thermal Biology 5 (1980), S. 249-251 
    ISSN: 0306-4565
    Keywords: Humans ; exercise ; hyperthermia ; oesophageal temperature
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
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  • 10
    ISSN: 1573-9686
    Keywords: Work of breathing ; Inspiratory pressure-time integral ; Respiratory modeling ; Dogs ; Humans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract We hypothesized that the viscoelastic properties of the respiratory system should have significant implications for the energetically optimal frequency of breathing, in view of the fact that these properties cause marked dependencies of overall system resistance and elastance on frequency. To test our hypothesis we simulated two models of canine and human respiratory system mechanics during sinusoidal breathing and calculated the inspiratory work ( $$\dot W$$ ) and pressure-time integral (PTI) per minute under both resting and exercise conditions. The two models were a two-compartment viscoelastic model and a single-compartment model. Requiring minute alveolar ventilation to be fixed, we found that both models predicted almost identical optimum breathing frequencies. The calculated PTI was very insensitive to increases in breathing frequency above the optimal frequencies, while $$\dot W$$ was found to increase slowly with frequency above its optimum. In contrast, both $$\dot W$$ and PTI increased sharply as frequency decreased below their respective optima. A sensitivity analysis showed that the model predictions were very insensitive to the elastance and resistance values chosen to characterize tissue viscoelasticity. We conclude that the $$\dot W$$ criterion for choosing the frequency of breathing is compatible with observations in nature, whereas the optimal frequency predictions of the PTI are rather too high. Both criteria allow for a fairly wide margin of choice in frequency above the optimum values without incurring excessive additional energy expenditure. Furthermore, contrary to our expectations, the viscoelastic properties of the respiratory system tissues do not pose a noticeable problem to the respiratory controller in terms of energy expenditure.
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  • 11
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 10 (1991), S. 177-184 
    ISSN: 0891-5849
    Keywords: Free radicals ; Humans ; Noninvasive analytical techniques ; Oxidative stress status
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 0027-5107
    Keywords: Cotinine ; Genetic monitoring ; Hprt mutation ; Humans ; Lymphocytes ; Pregnancy ; Smoking ; Tobacco
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular evolution 33 (1991), S. 442-449 
    ISSN: 1432-1432
    Keywords: Humans ; Mouse ; Rat ; Codon usage ; Mutation bias ; Selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A new statistical test has been developed to detect selection on silent sites. This test compares the codon usage within a gene and thus does not require knowledge of which genes are under the greatest selection, that there exist common trends in codon usage across genes, or that genes have the same mutation pattern. It also controls for mutational biases that might be introduced by the adjacent bases. The test was applied to 62 mammalian sequences, the significant codon usage biases were detected in all three species examined (humans, rats, and mice). However, these biases appear not to be the consequence of selection, but of the first base pair in the codon influencing the mutation pattern at the third position.
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1432-1432
    Keywords: Genome composition ; Coding sequences ; Isochores ; Humans ; Murids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The compositional distributions of coding sequences and DNA molecules (in the 50-100-kb range) are remarkably narrower in murids (rat and mouse) compared to humans (as well as to all other mammals explored so far). In murids, both distributions begin at higher and end at lower GC values. A comparison of homologous coding sequences from murids and humans revealed that their different compositional distributions are due to differences in GC levels in all three codon positions, particularly of genes located at both ends of the distribution. In turn, these differences are responsible for differences in both codon usage and amino acids. When GC levels at first+second codon positions and third codon positions, respectively, of murid genes are plotted against corresponding GC levels of homologous human genes, linear relationships (with very high correlation coefficients and slopes of about 0.78 and 0.60, respectively) are found. This indicates a conservation of the order of GC levels in homologous genes from humans and murids. (The same comparison for mouse and rat genes indicates a conservation of GC levels of homologous genes.) A similar linear relationship was observed when plotting GC levels of corresponding DNA fractions (as obtained by density gradient centrifugation in the presence of a sequence-specific ligand) from mouse and human. These findings indicate that orderly compositional changes affecting not only coding sequences but also noncoding sequences took place since the divergence of murids. Such directional fixations of mutations point to the existence of selective pressures affecting the genome as a whole.
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1432-1432
    Keywords: Humans ; Mitochondrial DNA ; Nuclear polymorphisms ; Heteroplasmy ; Genetic differentiation ; Sickle cell ; Rain forest refuges
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The identification of genetically coherent populations is essential for understanding human evolution. Among the culturally uniform ethnic groups of west Africa, there are two geographically distinct populations with high frequencies of sickle-cell hemoglobin (HbS). Although the HbS mutation in each group is found on distinguishable chromosomes 11, these populations have been assumed to be parts of a single population. Analysis of mitochondrial DNA (mtDNA) in these populations demonstrated that the two populations identified by alternative chromosomes 11 bearing HbS have distinct distributions of mitochondrial genotypes, i.e., they are maternally separate. These studies also showed that, contrary to expectation, the mtDNA of some individuals is heteroplasmic. For nuclear loci, a comparison of the frequency of alternative alleles established that these populations are genetically distinct. Both the mitochondrial and nuclear data indicate that these populations have been separate for approximately 50,000 years. Although HbS in the two populations is usually attributed to recent, independent mutations, the duration of the separation and the observed geographic distribution of the population allow for the possibility of an ancient origin of HbS. Assuming an ancient mutation and considering the known biogeography, we suggest that HbS protected selected populations from malaria in rain forest refuges during the most recent ice age.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1432-1432
    Keywords: Alu source genes ; Humans ; Gorillas ; Retrotransposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A member of the young PV Alu sub-family is detected in chimpanzee DNA showing that the PV subfamily is not specific to human DNA. This particular Alu is absent from the orthologous loci in both human and gorilla DNAs, indicating that PV subfamily members transposed within the chimpanzee lineage following the divergence of chimpanzee from both gorilla and human. These findings and previous reports describing the transpositional activity of other Alu sequences within the human, gorilla, and chimpanzee lineages provide phylogenetic evidence for the existence of multiple Alu source genes. Sequences surrounding this particular Alu resemble known transcriptional control elements associated with RNA polymerase III, suggesting a mechanism by which cis-acting elements might be acquired upon retrotransposition.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1432-1254
    Keywords: Briths ; Humans ; Solar wind ; Geomagnetism ; Melatonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Data obtained from the literature on the annual pattern of human conceptions and plasma melatonin at high latitudes indicated that simple annual rhythms do not exist. Instead, prominent semiannual rhythms are found, with equinoctial troughs and solsticial peaks. A prominent semiannual environmental event is the magnetic disturbance induced by the solar wind. The semiannual magnetic disturbances are worldwide, but most pronounced in the auroral zones where the corpuscular radiation enters the atmosphere. Magnetic indices that predominantly reflect these events were obtained from the literature and correlated with the melatonin and conception data. Significant and inverse correlations were found for Inuit conceptions and the melatonin data. The correlations obtained for 48 contiguous states of the United States indicated that only the extreme northern states exhibited this relationship. These data were compared with a previous correlational study in the United States which established that sunshine was correlated with conceptions in the middle latitude and southern states. An hypothesis of dual control by electromagnetic and magnetic energies is proposed: melatonin is a progonadal hormone in humans controlled by both factors, depending on their relative strength. Other studies are reviewed regarding the possible factors involved in determining the annual pattern of human conceptions. Demographic studies of geographic variation in temporal patterns of conceptions, with particular regard to variations of the magnetic fields on the earth's surface, may provide some insight into the efficacy of these different factors.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 0165-7992
    Keywords: Cytochrome P-450 ; Dogs ; Humans ; Monkeys ; P-448-H ; Rats
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
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  • 19
    ISSN: 0168-1591
    Keywords: Cats ; Foraging ; Humans ; Livestock ; Predators ; Vampire bats
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Ethology and Sociobiology 6 (1985), S. 183-187 
    ISSN: 0162-3095
    Keywords: Assortative mating ; Genetic similarity ; Heritability ; Humans ; Kin recognition
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
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  • 21
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Ethology and Sociobiology 8 (1987), S. 215-220 
    ISSN: 0162-3095
    Keywords: Humans ; Paternity confidence ; Relatedness
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
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  • 22
    Electronic Resource
    Electronic Resource
    Springer
    Mycopathologia 124 (1993), S. 73-77 
    ISSN: 1573-0832
    Keywords: Assessment ; Cancer ; Humans ; Hydrazines ; Mushroom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract This assessment focuses on the concentrations of some chemicals present in theAgaricus bisporus mushroom, the cancer-inducing doses of these chemicals or mushroom used in the animal experiments, the total amounts of these chemicals or mushroom needed to induce cancer in these mice, and the estimated total amounts of these chemicals or mushroom needed to induce cancer in humans. By adding the estimated amounts of chemicals needed to induce cancer and by comparing it with the amount of raw mushroom needed to induce the same effect, it becomes obvious that we have accounted for less than 2% of the carcinogenic components of theAgaricus bisporus mushroom. Since some unavailable data handicapped this assessment, it should be regarded as tentative and subject to further adjustment.
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  • 23
    ISSN: 1432-0878
    Keywords: Skeletal muscles ; Ultrastructure ; Exercise ; Glycogen ; Humans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Distribution of glycogen particles in semithin and ultrathin sections of biopsy samples from human muscles subjected to either short- or long-term running were investigated using PAS and Periodic Acid-ThioSemiCarbazide-Silver Proteinate (PA-TSC-SP) staining methods. Glycogen particles were predominantly found immediately under the sarcolemma or aligned along the myofibrillar Iband. After long-term exhaustive exercise type-1 fibers with a few or no glycogen particles in the core of the fibers were frequently observed. The subsarcolemmal glycogen stores of these “depleted” type-1 fibers were about three times as large as after exhaustive short-time exercise. Another indication of utilization of subsarcolemmal glycogen stores during anaerobic exercise was that many particles displayed a pale, rudimentary shape. This observation suggests fragmental metabolization of glycogen. Thus, depending on type of exercise and type of fiber differential and sequential glycogen utilization patterns can be observed.
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  • 24
    ISSN: 1435-9456
    Keywords: Key words Shape from shading ; Visual search ; Texture segregation ; Chimpanzees ; Humans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The perception of shape from shading was tested in two chimpanzees (Pan troglodytes) and five humans (Homo sapiens), using visual search tasks. Subjects were required to select and touch an odd item (target) from among uniform distractors. Humans found the target faster when shading was vertical than when it was horizontal, consistent with results of previous research. Both chimpanzees showed the opposite pattern: they found the target faster when shading was horizontal. The same difference in response was found in texture segregation tasks. This difference between the species could not be explained by head rotation or head shift parallel to the surface of the monitor. Furthermore, when the shaded shape was changed from a circle to a square, or the shading type was changed from gradual to stepwise, the difference in performance between vertical and horizontal shading disappeared in chimpanzees, but persisted in humans. These results suggest that chimpanzees process shading information in a different way from humans.
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  • 25
    Publication Date: 2017-01-04
    Description: The primary objective of this publication is to share with a wider audience the valuable information and extensive dialogue that took place amongst over 140 individuals who attended the second in a series of planned workshops on the science and management of coastal landforms in Massachusetts. This workshop took place at the Woods Hole Oceanographic Institution on January 24, 2001. The individuals who attended this workshop are actively engaged in planning, managing, regulating, engineering, educating, and studying coastal landforms and their beneficial functions. This workshop titled, Can Humans & Coastal Landforms Co-exist?’, was a natural follow-up to a previous workshop, Coastal Landform Management in Massachusetts, held at WHOI October 9-10, 1997 (proceedings published as WHOI Technical Report #WHOI-98-16). The workshop had a very practical, applied focus, providing state-of-the-art scientific understanding of coastal landform function, case history management and regulation of human activities proposed on coastal landforms, a multi-faceted mock conservation commission hearing presented by practicing technical consultants and attorneys that involved all attendees acting as regulators in breakout sessions, and, at the conclusion of the workshop, an open discussion on all issues related to the science and management of coastal landforms, including future research needs.
    Description: Funding for these proceedings was provided by WHOI Sea Grant and the NOAA National Sea Grant College Program Office, Department of Commerce, under NOAA Grant No. M10-2, Woods Hole Oceanographic Institution Sea Grant Project No. NA86R60075.
    Keywords: Coastal ; Landforms ; Humans
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
    Format: 1574993 bytes
    Format: application/pdf
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  • 26
    Publication Date: 2018-04-17
    Description: © The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in International Journal of Environmental Research and Public Health 15 (2018): 723, doi:10.3390/ijerph15040723.
    Description: There has been a massive increase in recent years of the use of lead (Pb) isotopes in attempts to better understand sources and pathways of Pb in the environment and in man or experimental animals. Unfortunately, there have been many cases where the quality of the isotopic data, especially that obtained by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS), are questionable, resulting in questionable identification of potential sources, which, in turn, impacts study interpretation and conclusions. We present several cases where the isotopic data have compromised interpretation because of the use of only the major isotopes 208Pb/206Pb and 207Pb/206Pb, or their graphing in other combinations. We also present some examples comparing high precision data from thermal ionization (TIMS) or multi-collector plasma mass spectrometry (MC-ICP-MS) to illustrate the deficiency in the Q-ICP-MS data. In addition, we present cases where Pb isotopic ratios measured on Q-ICP-MS are virtually impossible for terrestrial samples. We also evaluate the Pb isotopic data for rat studies, which had concluded that Pb isotopic fractionation occurs between different organs and suggest that this notion of biological fractionation of Pb as an explanation for isotopic differences is not valid. Overall, the brief review of these case studies shows that Q-ICP-MS as commonly practiced is not a suitable technique for precise and accurate Pb isotopic analysis in the environment and health fields
    Keywords: Lead isotopes ; ICP-MS ; TIMS ; MC-ICP-MS ; Environment ; Humans ; Rats ; Fractionation
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boffey, P M -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1246-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663606" target="_blank"〉PubMed〈/a〉
    Keywords: Cuba ; Health Manpower ; Humans ; *National Health Programs ; Preventive Health Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-03-03
    Description: The risk of a person getting cancer from ingesting saccharin is compared with the risk of ingesting additional calories which cause excess body weight. It is found that, for a person who is 10% overweight, the risk of ingesting one diet soft drink, which would cause a decrease in life expectancy of 9 seconds, is approximately equal to the risk of ingesting one additional kilocalorie; that is, if ingesting a diet drink inhibits ingestion of more than 1 kilocalorie, its benefits exceed its risks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, B L -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):983.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622580" target="_blank"〉PubMed〈/a〉
    Keywords: *Diet ; *Energy Intake ; Humans ; Neoplasms/*chemically induced ; Obesity/*etiology ; Risk ; Saccharin/*adverse effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-04-14
    Description: The body shapes of humans and chimpanzees were compared quantitatively by criteria chosen for their capacity to discriminate well among the body shapes of frogs. By these criteria, the difference in body shape between humans and chimpanzees was found to be greater than that between the most dissimilar pairs of frogs examined--that is, frogs classified in separate taxonomic suborders. Even though the morphological diffference between the two primates is large by frog standards, the biochemical differences between the structural genes of these two species are small. The results of this study give quantitative support to the proposal that morphological evolution and biochemical evolution in structural genes can proceed at independent rates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cherty, L M -- Case, S M -- Wilson, A C -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):209-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthropometry ; Anura/*anatomy & histology ; *Biological Evolution ; Biometry ; Genes ; Humans ; Pan troglodytes/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, B -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):207-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619453" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Eye Movements ; Humans ; Motor Neurons/*physiology ; Reticular Formation/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Comroe, J H Jr -- New York, N.Y. -- Science. 1978 May 26;200(4344):931-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644335" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiac Surgical Procedures/history ; *Diagnosis ; Drug Evaluation ; Drug Evaluation, Preclinical ; Education, Medical, Continuing ; Humans ; Peer Review ; Periodicals as Topic ; Preventive Medicine ; *Research ; Research Support as Topic ; Terminology as Topic ; *Therapeutics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-01-06
    Description: The human brain is found to produce a magnetic field near the scalp which varies in synchrony with periodic electrical stimulation applied to a finger. Use of a highly sensitive superconducting quantum interference device as a magnetic field detector reveals that the brain's field is sharply localized over the primary projection area of the sensory cortex contralateral to the digit being stimulated. The phase of the response at the stimulus frequency varies monotonically with the repetition rate and at intermediate frequencies yields a latency of approximately 70 milliseconds for cortical response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brenner, D -- Lipton, J -- Kaufman, L -- Williamson, S J -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):81-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, New York University, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569490" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*physiology ; Brain Mapping ; Electric Stimulation ; *Electromagnetic Fields ; Fingers ; Humans ; Male ; Reaction Time ; Thumb
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 33
    Publication Date: 1978-07-14
    Description: Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, J L -- Epstein, J -- Fontaine, J H -- Forbes, G B -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):180-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663650" target="_blank"〉PubMed〈/a〉
    Keywords: Amniotic Fluid/cytology ; Cell Survival/drug effects ; Cystic Fibrosis/diagnosis/genetics/*physiopathology ; Dexamethasone/*toxicity ; Drug Resistance ; Female ; Heterozygote ; Homozygote ; Humans ; Pregnancy ; Prenatal Diagnosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, Barbara J -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):274-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643429" target="_blank"〉PubMed〈/a〉
    Keywords: Biology ; Consumer Participation ; *DNA, Recombinant ; Federal Government ; Government ; *Government Regulation ; Humans ; *Legislation as Topic ; *Politics ; *Research Personnel ; Risk ; Risk Assessment ; *Social Control, Formal ; Societies
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  • 35
    Publication Date: 1978-03-17
    Description: Concentrations of luteinizing hormone in the serums of human neonates were altered when the neonates were exposed to prolonged, intense illumination (phototherapy) with their eyes covered. Concentrations decreased after 48 to 72 hours of exposure, increased 6 to 9 days after phototherapy, and subsequently returned to levels similar to those of controls. These data suggest that light may affect pituitary-gonadal function in the human neonate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dacou-Voutetakis, C -- Anagnostakis, D -- Matsaniotis, N -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1229-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628840" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Infant, Newborn ; Jaundice, Neonatal/blood/*therapy ; Luteinizing Hormone/*blood ; *Phototherapy ; Time Factors ; Vision, Ocular
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  • 36
    Publication Date: 1978-07-21
    Description: Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, K L -- Mohs, R C -- Tinklenberg, J R -- Pfefferbaum, A -- Hollister, L E -- Kopell, B S -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):272-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351807" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Adolescent ; Adult ; Alzheimer Disease/drug therapy ; Clinical Trials as Topic ; Humans ; Male ; Memory/*drug effects/physiology ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use
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  • 37
    Publication Date: 1978-11-24
    Description: When whole human blood is subjected to viscometric flow, individual red cells are seen to be elongated and oriented in the shear field. In addition, a tank tread-like motion of the membrane around the cell content occurs. In dilute suspensions of erythrocytes in viscous media, the same behavior is better observed and can also be measured quantitatively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischer, T M -- Stohr-Lissen, M -- Schmid-Schonbein, H -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):894-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715448" target="_blank"〉PubMed〈/a〉
    Keywords: *Blood Viscosity ; Erythrocyte Membrane/*physiology ; Erythrocytes/*physiology/ultrastructure ; Humans ; Rheology
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  • 38
    Publication Date: 1978-08-18
    Description: Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5'-nucleotidase is further suggested by normal values for lymphocyte ecto-adenosinetriphosphatase and ecto-nonspecific phosphatase. The data provide evidence for an enzyme deficiency in this X-linked, B lymphocyte deficiency syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, N L -- Magilavy, D B -- Cassidy, J T -- Fox, I H -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):628-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27864" target="_blank"〉PubMed〈/a〉
    Keywords: Agammaglobulinemia/*enzymology/genetics ; Cell Membrane/enzymology ; Female ; Genetic Linkage ; Humans ; Hydrogen-Ion Concentration ; IgA Deficiency ; Lymphocytes/*enzymology ; Male ; Nucleotidases/blood/*deficiency ; Rosette Formation ; T-Lymphocytes/immunology ; X Chromosome
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  • 39
    Publication Date: 1978-10-20
    Description: Explants of human chorion-decidual tissue obtained at delivery from normal, full-term pregnancies synthesize and secrete prolactin. This hormone is indistinguishable from pituitary prolactin by chromatographic, electrophoretic, immunologic, and receptor assay techniques. These results suggest that chorion-decidua may be the source of the large quantities of prolactin in amniotic fluid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Golander, A -- Hurley, T -- Barrett, J -- Hizi, A -- Handwerger, S -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694535" target="_blank"〉PubMed〈/a〉
    Keywords: Amnion/metabolism ; Amniotic Fluid/*metabolism ; Chorion/*metabolism ; Decidua/*metabolism ; Female ; Humans ; In Vitro Techniques ; Pregnancy ; Prolactin/*biosynthesis ; Trophoblasts/metabolism
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  • 40
    Publication Date: 1978-06-23
    Description: In cultures made from disaggregated human epidermal cells, growth to a confluent cell layer is followed by the emergence of patterns resembling those of human dermatoglyphs. These patterns reflect intrinsic properties of kertinocytes. In vivo, only the epidermis of the volar surfaces forms patterns, but in culture, patterns are formed by epidermal cells from other sites as well. Patterns develop by a process of cell movement which first produces ridges and then curves the ridges into figures of increasing complexity, ultimately whorls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, H -- Thomas, J -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663617" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Movement ; Cells, Cultured ; *Dermatoglyphics ; Embryonic Induction ; Epidermis/*cytology ; Fibroblasts/cytology ; Humans ; Time Factors
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-01-20
    Description: An anencephalic infant, 3 to 6 weeks old, responded to acoustic stimulation with cardiac decelerations typical of the response pattern seen in normal, older infants. Such precocity implies unexpected competence of lower brain structures and suggests that, in the normal infant, feedback from immature higher centers may sometimes interfere with rather than modulate the functioning of lower centers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham, F K -- Leavitt, L A -- Strock, B D -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):322-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619460" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Age Factors ; Anencephaly/*physiopathology ; *Behavior/physiology ; Brain/*physiopathology ; Habituation, Psychophysiologic/physiology ; *Heart Rate ; Humans ; Infant ; Infant, Newborn ; Orientation/physiology ; Reflex/physiology ; Sleep/physiology
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-06-09
    Description: The average length of postpartum amenorrhea reported by breast-feeding women in rural Bangladesh in 1975 was 18 to 20 months. Its duration was found to be only slightly related to maternal nutritional status. There was no evidence of a threshold of weight for height necessary for the resumption of menses postpartum. Factors related to the duration of postpartum amenorrhea were maternal age, socioeconomic status, and supplemental feeding of the infant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huffman, S L -- Chowdhury, A K -- Mosley, W H -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653359" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology ; Body Water/metabolism ; Body Weight ; Female ; Humans ; Infant Nutritional Physiological Phenomena ; *Lactation ; Maternal Age ; Menstruation ; Nutrition Disorders/metabolism ; *Nutritional Physiological Phenomena ; *Postpartum Period ; Pregnancy ; Socioeconomic Factors ; Time Factors
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: Long-term care for the aged in the United States is overly dependent upon the nursing home. This hospital-like model for long-term care is particularly inappropriate since it imposes a medical solution on a variety of social problems. An adequate long-term care program requires a range of resources in the community as well as in institutions; sheltered housing options seem a desirable alternative to the nursing home. To ensure the quality of nursing home care, the present focus on setting standards for care activities should be abandoned in favor of a focus on care outcomes (physical, mental, and social). In an effort to change our present perverse incentives in the nursing home industry, the proposal is made that nursing homes be reimbursed according to the degree to which patient outcomes meet predicted outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kane, R L -- Kane, R A -- New York, N.Y. -- Science. 1978 May 26;200(4344):913-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417403" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Financing, Government ; Health Facilities, Proprietary ; *Homes for the Aged/economics ; Humans ; Long-Term Care/*methods ; *Nursing Homes/economics/standards ; Socioeconomic Factors ; United States
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  • 44
    Publication Date: 1978-03-24
    Description: Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon endogenous virus (BEV)--infected human fibroblasts. Responsiveness peaked during the second and third trimesters and corresponded temporally with elevated antibody levels to BEV antigens. Similar cell-mediated reactivity was not observed in nonpregnant individuals. Selective cell-mediated reactivity directed against cells infected with the simian sarcoma virus-simian sarcoma associated virus complex (SSV--SSAV) was observed in four of 20 healthy adults (three of 14 nonpregnant, one of six pregnant). These observations suggest that cell-mediated reactivity against primate C-type oncoviruses is occasionally detected in healthy nonpregnant adults, but that during pregnancy both cell-mediated and humoral reactivity against BEV may become selectively expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirsch, M S -- Kelly, A P -- Chapin, D S -- Fuller, T C -- Black, P H -- Kurth, R -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1337-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204010" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*analysis ; *Antigens, Viral ; Female ; Humans ; *Immunity, Cellular ; Papio/microbiology ; *Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Retroviridae/*immunology ; Sarcoma Virus, Woolly Monkey/immunology
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-11-24
    Description: A well-known solution of the diffusion equation gives an exponential square-root function as the frequency response for a one-dimensional diffusion or transmission process. When two or more such processes are cascaded, the result is still an exponential square-root characteristic, but with a longer time constant. This seems to explain why flicker thresholds obey the Kelly-Veringa diffusion model at high frequencies, even though the psychophysically inferred diffusion process is much slower than the first stage of visual transduction measured by, for example, late receptor potentials. Two such stages in tandem are sufficient to account for the psychophysical data, because the psychophysical time constant is proportional to the square of the number of stages involved. In addition, the nonlinear behavior of flicker thresholds under intense light adaptation can be explained if the loss factor in the first stage is proportional to the amount of the photopigment bleached. Apparently the flicker thresholds are governed by first- and second-order retinal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelly, D H -- Wilson, H R -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):896-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715449" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Diffusion ; Flicker Fusion/*physiology ; Humans ; Light ; Models, Biological ; Photoreceptor Cells/physiology ; Retina/*physiology ; Retinal Pigments/physiology ; Time Factors
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  • 46
    Publication Date: 1978-02-03
    Description: The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Stimulating Factors/*physiology ; Feedback ; Glycoproteins/*physiology ; Granulocytes/*cytology ; *Hematopoiesis ; Humans ; Leukocytes/*cytology ; Macrophages/cytology/*physiology ; Mice ; Models, Biological ; Monocytes/*physiology ; Prostaglandins E/*physiology
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):200-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694526" target="_blank"〉PubMed〈/a〉
    Keywords: Bromocriptine/therapeutic use ; Clomiphene/therapeutic use ; Female ; Humans ; Infertility/psychology/*therapy ; Infertility, Female/etiology ; Male ; Ovulation ; Prolactin/blood
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  • 48
    Publication Date: 1978-12-08
    Description: Nineteen epileptic patients were tested first under medium (week 1) and then under high (week 2) therapeutic levels of phenobarbital. Relative to response times of 20 controls with equivalent practice but without medication, response times of patients in a short-term memory scanning task were strikingly slowed during week 2. However, increased phenobarbital did not slow responses in a task requiring access to information in long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLeod, C M -- Dekabian, A S -- Hunt, E -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1102-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715461" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Dose-Response Relationship, Drug ; Epilepsy/*drug therapy ; Humans ; Memory, Short-Term/*drug effects ; Middle Aged ; Phenobarbital/adverse effects/*pharmacology
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1068-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715458" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*diagnosis/genetics ; DNA Restriction Enzymes/*metabolism ; Female ; Globins/genetics ; Humans ; Pregnancy ; Prenatal Diagnosis/*methods ; Thalassemia/*diagnosis
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):799-801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684407" target="_blank"〉PubMed〈/a〉
    Keywords: Botulinum Toxins/analysis ; Botulism/*complications/mortality ; Honey/adverse effects ; Humans ; Infant ; Sudden Infant Death/*etiology/microbiology
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1270-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725601" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Drug ; Estrogens/*adverse effects ; Female ; Hemorrhage/etiology ; Humans ; Risk ; Uterine Diseases/etiology ; Uterine Neoplasms/diagnosis/*etiology
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  • 52
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-06-02
    Description: Inoculation of the buffy coat of blood from guinea pigs infected with Creutzfeldt-Jakob disease resulted in passage of this disease to recipient animals. This demonstrates that there is a viremia in experimental Creutzfeldt-Jakob disease. These findings suggest that the hematogenous route may be implicated in the human infection and that the disease may possibly be transmitted by blood transfusions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manuelidis, E E -- Gorgacs, E J -- Manuelidis, L -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1069-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/349691" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood/*microbiology ; Creutzfeldt-Jakob Syndrome/blood/*microbiology/transmission ; *Disease Models, Animal ; Guinea Pigs ; Humans ; Leukocytes/microbiology
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):949-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715452" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants/toxicity ; Dose-Response Relationship, Drug ; Environmental Exposure ; Government Agencies ; Humans ; Industry ; Ozone/toxicity ; United States
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):515-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/307276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Cell Transformation, Neoplastic ; *Cocarcinogenesis ; Dietary Fats/adverse effects ; Epidermal Growth Factor/metabolism ; Humans ; Neoplasms/*chemically induced ; Ornithine Decarboxylase/metabolism ; Phenobarbital ; Plasminogen Activators/metabolism ; Receptors, Drug/metabolism ; Saccharin ; Smoking/complications ; Tetradecanoylphorbol Acetate
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-11-24
    Description: The concentration of the primary brain metabolite of norepinephrine is diminished in the lumbar spinal fluid of patients with Korsakoff's syndrome. The extent of its reduction is significantly correlated with measures of memory impairment for individual patients. These data suggest that the memory disorder of Korsakoff's syndrome may result from damage to ascending noradrenergic pathways by the diencephalic and brainstem lesions associated with this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McEntee, W J -- Mair, R G -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):905-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715450" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohol Amnestic Disorder/*cerebrospinal fluid/metabolism ; Brain/metabolism ; Glycols/*cerebrospinal fluid ; Homovanillic Acid/cerebrospinal fluid ; Humans ; Hydroxyindoleacetic Acid/cerebrospinal fluid ; Memory Disorders/*cerebrospinal fluid ; Methoxyhydroxyphenylglycol/*cerebrospinal fluid ; Norepinephrine/metabolism ; Vanilmandelic Acid/cerebrospinal fluid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 56
    Publication Date: 1978-09-01
    Description: Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonagh, A F -- Ramonas, L M -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):829-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/581101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bile/metabolism ; Bilirubin/blood/*metabolism/radiation effects ; *Disease Models, Animal ; Humans ; Infant, Newborn ; Jaundice, Neonatal/*therapy ; Kinetics ; Liver/metabolism ; *Phototherapy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 57
    Publication Date: 1978-07-28