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  • Articles  (10,175)
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  • Articles  (10,175)
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  • 1
    Electronic Resource
    Electronic Resource
    Earthquake induced damage in an historic area: the September–October 1997 seismic sequence which affected Assisi, Central Italy (1998)
    Springer
    Bulletin of engineering geology and the environment 57 (1998), S. 101-109 
    Details
    ISSN: 1435-9537
    Keywords: Key words Assisi Earthquake ; Seismology ; Historic buildings ; Umbria-Marche ; Seismic microzonation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé La sequence sismique de septembre–octobre 1997 qui a affecté l'une des régions historiques les plus importantes d'Italie Centrale a mis en évidence que l'impact économique des tremblements de terre de magnitude modérée peut être considérable. En ce qui concerne la vulnerabilité du patrimoine artistique et architectural, on a constaté que des trésors inestimables pouvaient subir des dégâts importants même lors de secousses modérées. On attire l'attention sur le fait qu'un microzonage sismique ne pourra être efficace que si l'on prend en compte non seulement l'activité sismique passée mais aussi l'historique des développements urbains.
    Notes: Abstract  The September–October 1997 seismic sequence in one of the most important historic areas of Central Italy showed that the economic impact of earthquakes of only moderate magnitude can be high. In view of the vulnerability of the artistic and architectural heritage, priceless treasures in such towns as Assisi are very susceptible to damage as a consequence of such seismic events. Attention is drawn to the fact that for seismic microzonation to be effective, it is essential that not only the past seismic activity but also the history of the urban developments is taken into account.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100640050026
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  • 2
    Electronic Resource
    Electronic Resource
    Immobilization osteoporosis and active vitamin D: Effect of active vitamin D analogs on the development of immobilization osteoporosis in rats (1981)
    Springer
    Calcified tissue international 33 (1981), S. 623-630 
    Details
    ISSN: 1432-0827
    Keywords: Osteoporosis ; Immobilization ; Rats ; Vitamin D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The therapeutic effects of vitamin D analogs, 1,24(R)-dihydroxycholecalciferol [1,24(R)(OH)2D3], 1,24(S)-dihydroxycholecalciferol [1,24(S)(OH)2D3], and 1,25-dihydroxycholecalciferol [1,25(OH)2D3] on immobilization osteoporosis were studied in rats. The right hind limb was immobilized through application of a plaster cast following the section of the sciatic nerve. The left hind limb was intact. Vitamin D analogs were orally administered for 6 weeks at dose levels of 0.02 and 0.10µg/kg/day, respectively. The mean lengths of the immobilized femurs were not significantly different from those of the intact femurs in all the experimental groups. In the immobilized femur of animals treated with 1,24(R)(OH)2D3, 0.10µg/kg, dry and ash weights were heavier and calcium and phosphorus contents greater than those in the nontreated group. Furthermore, the amount of calcified bone mass and the cortical thickness of the femurs of the immobilized limb in 1,24(R)(OH)2D3-treated animals were greater than those in the nontreated animals. Treatment with 1,25(OH)2D3 at 0.10µg/kg caused an increase of the bone mass in both immobilized and intact femurs when compared with those of the control group. It was concluded that the administration of 1,24(R)(OH)2D3 diminished the effect of immobilization in the development of osteoporosis without any side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409500
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  • 3
    Electronic Resource
    Electronic Resource
    Maintenance of a calcemic response to parathyroid hormone in D-deficient rats by the prevention of severe hyperparathyroidism (1977)
    Springer
    Calcified tissue international 23 (1977), S. 277-281 
    Details
    ISSN: 1432-0827
    Keywords: PTH ; Vitamin D ; Pituitary ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Parathyroid gland transplanted rats and hypophysectomized rats were raised from weaning on a diet without vitamin D and low in calcium (0.02%) for 4 weeks. At the end of this period the animals of both experimental groups, when compared to their respective controls (i.e., sham-operated animals for parathyroid-transplanted ones, and hypophysectomized plus bovine growth hormone-supplemented ones for hypophysectomized rats) were characterized by (a) moderate or absent secondary hyperparathyroidism; (b) near normal bone calcium content; and (c) a maintained responsiveness to the calcemic effect of parathyroid extract (PTE). The PTE action is a bone effect that does not require the presence of the kidneys and is not related to changes in serum calcium and/or phosphorus concentrations. These results indicate that when severe hyperparathyroidism is prevented, the sensitivity of bone to the calcemic action of PTE can be maintained in D-deficient calcium-deprived rats. They also suggest that in these animals the main factor leading to resistance to PTH is the state of severe chronic hyperparathyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012797
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  • 4
    Electronic Resource
    Electronic Resource
    Dissociation of renal cyclic AMP and phosphate responses to parathyroid hormone in uremia (1979)
    Springer
    Calcified tissue international 29 (1979), S. 147-154 
    Details
    ISSN: 1432-0827
    Keywords: Vitamin D ; Chronic uremia ; Rats ; Renal responsivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Various investigators have shown that chronic uremia is associated with a normal or exaggerated phosphaturic response to parathyroid hormone (PTH). To explore the relationship between progressive uremia, renal tubular cyclic AMP (cAMP), and inorganic phosphate (Pi) response to PTH and acidosis, in vivo and in vitro experiments were designed in rats with experimental uremia of 4–6 weeks’ duration. Both uremic and pair-fed control rats were treated with 1,25-dihydroxycholecalciferol (1,25(OH)2D3) and/or chronic NH4Cl feeding. Urinary Pi and cAMP and plasma immunoreactive PTH (iPTH) were measured as well as PTH- and NaF-stimulated cAMP from isolated renal tubules. Excretion of cAMP decreased by 30% in uremic as compared to control rats despite a 3-fold rise in Pi excretion. Acidosis superimposed on uremia did not further decrease cAMP excretion, nor did it significantly alter the elevated Pi excretion. 1,25(OH)2D3 treatment of uremic rats further lowered cAMP excretion although Pi excretion rose, hypercalcemia occurred, and plasma iPTH fell. In nonuremic control rats, 1,25(OH)2D3 treatment led to hypercalcemia, a progressive decrease in cAMP, and increase in Pi excretion. Isolated renal tubules from uremic or acidotic uremic rats revealed a 50% reduction in both PTH- and NaF-stimulated cAMP generation compared to control rat renal tubules. This observation was unchanged by 1,25(OH)2D3 treatment. Renal tubules of 1,25(OH)2D3-treated control rats demonstrated a decreased cAMP production in response to both PTH and NaF which was inversely related to the calcium content of the renal tubules. Renal tubular calcium levels of uremic rats, initially 3-fold elevated, also increased during 1,25(OH)2D3 treatment. These results are consistent with the hypothesis that progressive uremia results in a dissociation between PTH, urinary cAMP, and Pi excretion which cannot be explained by either metabolic acidosis or 1,25(OH)2D3 deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408070
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  • 5
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of castrate rat bone (1982)
    Springer
    Calcified tissue international 34 (1982), S. 547-552 
    Details
    ISSN: 1432-0827
    Keywords: Rats ; Osteoporosis ; Anorganic ; Femur ; Castrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The study describes the SEM appearances of endosteal and periosteal surfaces of anorganic femoral diaphyses from 16-month-old normal and castrate male rats. Different types of surfaces could be recognized in both groups. Percentage areas occupied by each surface type were analyzed with a Ladd Data Analyzing Digitizer. Endosteal surfaces were composed of significantly more (P〈0.05) incompletely mineralized, forming surface and significantly less (P〈0.05) completely mineralized, resting surface in castrates than in controls. Both endosteal and periosteal surfaces from experimental bone demonstrated significantly more (P〈0.05) osteoblast lucunae than did control surfaces, and vascular canal entrances were significantly wider (P〈0.001) on castrate endosteal surfaces than on control endosteal surfaces. There was a greater proportion of small nodule forming surface/large nodule forming surface in castrate endosteal bone than in control, and a greater proportion prolonged resting surface/fibrous resting surface in control periosteal bone than in castrate. The results indicate that, when viewed in the SEM, anorganic endosteal and periosteal bone surfaces from femoral diaphyses of old castrate male rats demonstrate appearances characteristic of changes in bone turnover that occur with osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411302
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  • 6
    Electronic Resource
    Electronic Resource
    Verapamil induces increased bone volume and osteopenia in female rats but has the opposite effect in male rats (1992)
    Springer
    Calcified tissue international 50 (1992), S. 524-526 
    Details
    ISSN: 1432-0827
    Keywords: Verapamil ; Bone ; Osteopenia ; Rat ; Female ; Intestinal calcium absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Verapamil inhibits the intestinal absorption of calcium (Ca) and increases serum parathyroid hormone in rats. The effects of verapamil on bone tissue after long-term treatment is, however, not well described. Adult female and male Sprague-Dawley rats received verapamil in their drinking water at a dosage of 0.075 mg/ml (low dose) or 0.75 mg/ml (high dose) for 12 weeks; control rats received only drinking water. All rats were fed a diet containing 0.1% Ca and 0.5% P. In female rats, the amount of bone ash per volume was significantly reduced from 0.742 g/ml in controls to 0.713 g/ml after low-dose treatment of verapamil, and to 0.667 g/ml following high-dose treatment (P〈0.01). The tibial length was increased from 39.7 mm in controls to 40.3 mm or to 40.7 mm after low or high doses (P〈0.01). The tibial volume increased from 0.385 ml in controls to 0.397 ml after low doses and to 0.429 ml after high doses (P〈0.01). In contrast, in male rats the amount of bone ash per volume was significantly increased from 0.578 g/ml in controls to 0.580 g/ml after low doses and to 0.620 g/ml after high doses of verapamil (P〈0.01). The tibial bone volume in males as decreased from 0.633 ml in controls to 0.641 ml after low doses and to 0.583 ml after high doses (P〈0.05). The tibial length in the males was not changed by verapamil. The intestinal absorption of Ca was reduced in male rats from 5.28 in controls to 4.03 (serosa/mucosa) after low-dose treatment and to 2.46 after high-dose treatment with verapamil (P〈0.05). In female rats, the intestinal absorption of Ca did not change after verapamil treatment. Thus, chronic treatment with verapamil in female rats induced osteopenia whereas in male rats bone growth was inhibited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582167
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  • 7
    Electronic Resource
    Electronic Resource
    Cigarette smoking, steroid hormones, and bone mineral density in young women (1992)
    Springer
    Calcified tissue international 50 (1992), S. 300-305 
    Details
    ISSN: 1432-0827
    Keywords: Female ; Smoking ; Estradiol ; Testosterone ; Sex hormone-binding globulin ; Cortisol ; Bone density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary There are few studies of the effect of smoking on bone density in young women. The reported antiestrogenic effect of smoking could be a mechanism for a possible effect of smoking on bone. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry (whole body, proximal femur, lumbar spine), and serum levels (midfollicular phase) of testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), and cortisol in 52 women (25 smokers, 27 nonsmokers) aged 20–35 years. The two groups did not differ significantly in age, height, weight, or the sum of eight skinfold thicknesses. The mean number of cigarettes smoked per day and the number of years of smoking were 16.9 and 12.9, respectively. There were no significant differences in BMD between smokers and nonsmokers at any site. For both smokers and nonsmokers, SHBG and the free androgen index (T/SHBG) made significant contributions (P〈0.005) to the variance in BMD at all sitesexcept the lumbar spine. The free estradiol index (E2/SHBG) contributed to whole body BMD (P〈0.05). For all subjects, there were significant inverse relationships between SHBG and BMD (P〈0.002), and positive relationships between T/SHBG and BMD (P〈0.02) for all sites except the lumbar spine. These data suggest that moderate smoking in young women is not associated with low BMD at any site. However, smokers had lower free estradiol and higher SHBG, both of which have been related to increased bone loss in older women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301626
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  • 8
    Electronic Resource
    Electronic Resource
    Localized, multiform, sub-periosteal hyperplasia and generalized osteomyelosclerosis in magnesium-deficient rats (1972)
    Springer
    Calcified tissue international 9 (1972), S. 17-27 
    Details
    ISSN: 1432-0827
    Keywords: Periosteal Hyperplasia ; Osteomyelosclerosis ; Magnesium ; Parathyroid ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Un régime contenant 0.8 à 2 mg de Mg pour 100 g, administré à des rats jeunes ou adultes pendant 18 à 21 jours, provoque une croissance généralisée d'os médullaire (ostéomyélosclérose), ainsi que des tumeurs périostées de type desmoide, au niveau de la linea aspera du fémur. Ces modifications s'accompagnent d'une décroissance du magnésium osseux de 52 à 71%, déterminée par spectrophotométrie d'absorption atomique. Au niveau des tumeurs périostées, la parathyroidectomie favorise la formation de cartilage. L'administration d'extrait parathyroidien inhibe la formation de cartilage en faveur de la formation de tissue fibreux et d'os. L'adjonction de magnésium au régime restitue rapidement l'apparence normale des tissus.
    Abstract: Zusammenfassung Eine Nahrung mit 0,8–2 mg Mg per 100 g wurde jungen oder ausgewachsenen Ratten während 18–21 Tagen verfüttert; sie verursachte ein generalisiertes medulläres Knochenwachstum (Osteomyelosklerose) und ebenso desmoidartige Tumoren, des Periosts an der femoralen Linea aspera. Diese Veränderungen waren von einer Abnahme von 52–71% der Magnesium-Konzentration im Knochen begleitet (Bestimmung am Atomabsorptions-Spektrophotometer). Bei Tumoren des Periosts wurde die Knorpelbildung durch Parathyreoidektomie begünstigt. Durch Verabreichung von Parathyreoidea-Extrakt wurde die Knorpelbildung gehemmt und an deren Stell fibröses Gewebe und Knochen gebildet. Wurde der Nahrung Magnesium zugesetzt, so bekamen die Gewebe rasch ein normales Aussehen.
    Notes: Abstract A diet containing from 0.8 to 2 mg Mg/100 g, fed to young or adult rats for 18 to 21 days produced generalized medullary bone growth (osteomyelosclerosis) and also periosteal tumours of the desmoid type, at the femoral linea aspera. These changes were accompanied by decreases in bone magnesium concentration of 52 to 71% as measured by atomic absorption spectrophotometry. In the periosteal tumours, parathyroidectomy favoured cartilage formation. The administration of parathyroid extract inhibited cartilage formation in favour of fibrous tissue and bone production. The addition of magnesium to the diet quickly restored the normal appearance of the tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02061942
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  • 9
    Electronic Resource
    Electronic Resource
    The detection and recognition of underground nuclear explosions (1995)
    Springer
    Surveys in geophysics 16 (1995), S. 495-532 
    Details
    ISSN: 1573-0956
    Keywords: Nuclear explosion detection and recognition ; Seismology ; Remote sensing ; Radioactivity ; Ionospheric effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract This paper reports on a joint meeting of the Royal Astronomical Society's Joint Association for Geophysics and VERTIC (the Verification Technology Information Centre) held in London in 1992. The topics presented focused on the detection and recognition of underground nuclear explosions. The objective of the meeting was to emphasize the multi-methodological approach that is important in verifying compliance with test-ban treaties. An overview of seismological monitoring was followed by a discussion of the technical and scientific aspects of a global seismic monitoring network, and in particular of the 1991 experiment to test the large-scale international exchange of seismic data between recording stations and data centres world-wide. The current capabilities of satellite remote-sensing were presented, and their use explained in terms of both the provision of information for monitoring the development of foreign nuclear testing programmes and also for providing sufficient information for the evaluation of treaty compliance. A review of radio-isotope sampling showed how the isotopic signature of both air and ground based sampling programmes can be diagnostic of the nuclear source. Finally, previously classified research on the ionospheric effects of underground nuclear explosions was presented, the generated acoustic waves disturbing the ionosphere and producing detectable changes in the reflection of radio and radar signals which have potential as a monitoring technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00665683
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  • 10
    Electronic Resource
    Electronic Resource
    Higher mode dispersion measurement (1978)
    Springer
    Pure and applied geophysics 116 (1978), S. 1274-1283 
    Details
    ISSN: 1420-9136
    Keywords: Seismology ; Surface-wave dispersion ; Higher mode surface waves ; Italy, phase vel. of surface waves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A new method is presented for the determination of higher mode dispersion over small distances, using two stations. From an intermediate focus earthquake it has been possible to measure the dispersion of the first and second Rayleigh modes in the period range 25–35 sec and 25–70 sec respectively. Using the almost linear array of Italian long-period stations TRI, BLZ, OLB an estimate of the average errors is also made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874686
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