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  • Books  (130)
  • Cell & Developmental Biology
  • Chemical Engineering
  • Humans
  • Inorganic Chemistry
  • thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 1
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: In the past decade, we have witnessed innovation in surgical treatment for renal cell carcinoma (RCC), including robotic platforms with integration of imaging approaches, and advances in targeted therapy, immunotherapy, and combination therapy to treat patients with advanced RCC. This book presents updated information on the epidemiology, genetics, diagnosis, screening, and advances in the treatment and management of RCC. It is a useful resource for any clinician involved in the management of patients with RCC, as well as other physicians, researchers, and patients.
    Keywords: immunotherapy ; genetics ; ultrasound ; mri ; targeted therapy ; epigenetic ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 2
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Pancreatic Cancer - Updates in Pathogenesis, Diagnosis and Therapies presents the most recent knowledge on pancreatic cancer, which is a deadly, challenging and catastrophic tumor with a high mortality rate. It is the seventh leading cause of cancer-related mortality worldwide. Pancreatic cancer can be diagnosed clinically, by laboratory measures, by imaging, and by pathological detection. Understanding tumor pathogenesis as well as tumor risk factors is necessary for successful treatment, as is early detection and multidisciplinary treatment. This book provides a comprehensive overview of pancreatic cancer in four sections. Chapters address such topics as prevention, screening, and detection; pathogenesis and risk factors; and pathology and management.
    Keywords: pancreas ; obesity ; epidemiology ; risk factors ; screening ; pathology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 3
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book offers outstanding approaches to understanding the role of the tumor microenvironment (TME) in cancer development and metastasis. The TME, with its multifaced role, is fundamental in the control and exacerbation of almost all cancer types. The outcome of many solid tumors is dependent on the modulation of the TME. Local tumor immunity, which is crucial in the control of cancer promotion, is one of the leading compounds of the TME. This book presents new insights and provides detailed and updated descriptions of the role of the TME in the control and the development of almost all cancer types. This book is an authentic source of knowledge, useful for researchers, medical doctors, students, and all individuals interested in understanding the mechanisms of cancer control and development.
    Keywords: cancer ; metabolism ; lung cancer ; nutrients ; minimally invasive surgery ; liquid biopsy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 4
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book describes and discusses numerous new concepts and procedures for the diagnosis and management of all types of neurofibromatosis (NF). It includes five chapters that address numerous topics in the field, including the management of toxicities associated with NF treatment modalities. It provides useful information and data for both researchers and practitioners to develop new approaches for the management of NF.
    Keywords: Neurofibromatosis 1 ; Schwannomatosis ; Risk Factors ; Neurofibromatosis 2 ; Epidemiology ; Diagnosis ; Cancer Therapies ; Physiological Dysfunction ; Chemotherapy ; Surgery ; Monitoring ; Gene Immunotherapy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 5
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book provides a comprehensive overview of multiple myeloma. It is organized into three sections with chapters addressing topics such as diagnosis, risk stratification, and management of multiple myeloma; treatment of multiple myeloma at diagnosis and at relapse; management of disease complications; and stem cell therapies, including autologous and allogeneic hematopoietic stem cell transplantation with a focus on autologous grafting using non-cryopreserved stem cells and performance of stem cell transplantation in outpatient settings.
    Keywords: cryopreservation ; chemotherapy ; quality of life ; hematopoietic stem cell transplantation ; monoclonal antibodies ; adverse effects ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 6
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: There are many different types of cancer. Some are very common; others are rare. Having some similar features, each cancer has its own characteristics and symptoms, which vary according to the type of cancer and where it is in the body. The treatment selected may be influenced by the patient's age, concurrent health problems, life expectancy, characteristics of the individual's cancer, the patient's goals of treatment, and the bias of the treating physician. In preparing this book, we have considered and reflected on the concept of the recent advances in cancer management and therapy as well as molecular applications in cancer therapy. The readers can find detailed information about the treatment and management of specific cancers in these book chapters.
    Keywords: breast cancer, immunotherapy, apoptosis, colorectal cancer, lung cancer, targeted therapy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 7
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book covers specific chapters with fundamental and current concepts about the main primary intracranial tumors, aimed at general neurosurgeons, neurologists, oncologists, radiotherapists, and residents. They are everyday situations from the subspecialist routine that can become challenging for professionals outside referenced centers or working alone.
    Keywords: glioblastoma, magnetic resonance imaging, gliomas, immunotherapy, biomarker, chemotherapy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 8
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available. This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives.
    Keywords: neuroendocrine neoplasm ; neuroendocrine carcinoma ; Ki67 labeling index ; Ki67 proliferation index ; adrenocortical tissues ; EMT ; epithelial markers ; mesenchymal markers ; recurrence-free survival ; neuroendocrine neoplasms ; molecular targeted therapies ; mTOR inhibitors ; somatostatin analogs ; TPH inhibitors ; meta-analysis ; medullary thyroid cancer ; calcitonin ; MEN2 ; gene carriers ; adrenocortical cancer ; metastatic pheochromocytoma ; metastatic paraganglioma ; checkpoint inhibitors ; avelumab ; ipilimumab ; nivolumab ; pembrolizumab ; neuroendocrine tumor ; GEP-NET ; PET/CT ; PRRT ; DOTATOC ; crcinoid crisis ; neuroendocrine tumors ; hemodynamic instability ; octreotide ; neuroendocrine ; molecular profiling ; targeted therapies ; mutation ; fusion ; ctDNA ; anaplastic thyroid carcinoma ; chemotherapy ; immune checkpoint inhibitors ; tumors associated macrophages ; radiotherapy ; molecular targeted therapy ; gastroenteropancreatic neuroendocrine neoplasms ; patient-derived xenograft ; tumor spheroids ; somatostatin receptor-2 ; near infrared-labelled octreotide analog ; management ; Delphi ; consensus ; pancreatic neuroendocrine tumor ; everolimus ; angiogenesis ; circulating cells ; biomarkers ; n/a ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 10
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance.
    Keywords: immunotherapy, tumor microenvironment, irreversible electroporation, therapy, computer-assisted surgery ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 11
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book entitled Cervical Cancer - Screening, Treatment and Prevention Universal Protocols for Ultimate Control is the fourth successful endeavor of the Editor with InTech publisher. The four books serve as four pillars in cervical cancer control, globally. This book is unique and sensational. Public health "topics" are assuming a status of "phenomenon," through deliberations and research. Screening is riddled with global limitations of availability, affordability, acceptability, and accessibility. The treatment of precancers has questionable efficiency. Prevention is costly with the inclusion of HPV vaccine. This book helps to find the solutions. The authors, editor, and InTech publisher wish the readers a pleasant and purposeful reading. This book is a "readers' feast," "receivers' choice," and "respondents' delight." Enjoy and treasure the international facts and flavors.
    Keywords: human papillomavirus, biomarker, microbiome, carcinogenesis, radiation, genetic variation ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 12
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.
    Keywords: breast cancer, colorectal cancer, lung cancer, mirna, dna repair, arsenic ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 13
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Pheochromocytoma, paraganglioma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. These neoplasms are associated with significant morbidity and mortality. Some international studies currently underway are researching and evaluating the presence of any similarities and differences between these tumors. Hopefully, future results will reveal several potential novel genes and pathways that might have major roles in the pathogenesis and progression of these neoplasms. This book discusses epidemiology, genetics, and treatment of these malignancies.
    Keywords: chemotherapy, metastasis, mirna, dna methylation, epigenetic, laparoscopic surgery ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 14
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book discusses the application of bioinformatics in cancer disease management. It covers general aspects of cancer as a disease but also as a success story in the translation of omics data in clinical settings. It provides an overview of the specific applications of bioinformatics tools in cancer epidemiology, prevention, and screening and in the identification of novel genetic and molecular biomarkers involved in cancer development. This is accomplished through the inclusion of numerous examples of the use of bioinformatics in precision oncology.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 15
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Glioblastoma (GBM) is a common and aggressive brain cancer with features of necrosis and endothelial proliferation in the histopathologic examination. Its presentation and management depend on tumor location, size, grade, and underlying histopathological characteristics. GBM tumors have clinical features of increased intracranial pressure, focal neurological deficits, or seizures (generalized or partial) with rapid progression. This book discusses GBM and its diagnosis, treatment, and management.
    Keywords: immunotherapy ; chemotherapy ; glioma ; genetics ; biomarker ; elderly ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 16
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    Springer Nature | Springer Berlin Heidelberg
    Publication Date: 2024-04-01
    Description: This open access book will provide a foundation for the understanding of, and knowledge for a successful routine use of diagnostic Nuclear Medicine procedures in children through expertise and cases provided by representative busy pediatric nuclear medicine facilities. The book highlights important aspects of nuclear medicine in children and the differences between adult and pediatric practice where relevant. An introductory chapter provides general information detailing the advantages and limitations for performing nuclear medicine tests in children, as well as suggestions on how to approach and provide relevant data to the patients, their parents or next of kin. In the remaining 11 chapters, containing over 115 cases of children evaluated for various clinical indications, procedures are presented and subsequently detailed according to their clinical significance or prevalence based on the clinical experience of the contributors. The book is organized by organ systems, and also includes chapter on oncology and infection/ inflammation. Chapters are formatted to provide information regarding clinical indications, preparation including radiopharmaceutical doses and additional medications, study protocol, study interpretation, correlative imaging. Each chapter will include red flags warning and take home messages sections to emphasize important points. The case format is presented with patient history and then study report and impression. Based on practices explored by experts at the forefront of this field, the publication is directed at Nuclear Medicine physicians, radiologists, oncologists and clinicians in various pediatric specialties, medical physicists, medical technologists, radiopharmacists, laboratory medicine scientists and researchers.
    Keywords: Hybrid imaging ; Theranostics ; Management of childhood diseases ; SPECT/CT ; PET/CT ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKR Nuclear medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKD Paediatric medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology ; thema EDItEUR::M Medicine and Nursing::MN Surgery::MNS Surgical orthopaedics and fractures
    Language: English
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  • 17
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.
    Keywords: cancer, targeted therapy, obesity, immunotherapy, metabolism, microrna ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 18
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Metastasis is the major cause of cancer-related death. It is a multistep process. The mechanism underlying metastasis is complicated and poorly understood. Recent advances in tumor metastasis research have led to improved diagnosis and clinical management of cancer. However, new strategies on metastasis treatment are urgently needed, especially the novel biomarkers discovery and targeted therapy. This book is designed to present the most recent advances in tumor metastasis.
    Keywords: cancer, breast cancer, drug delivery, exosomes, extracellular matrix, ovarian cancer ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 19
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Melanoma is an aggressive type of cancer for which treatment has dramatically evolved during the last 15 years, improving response and survival figures. This book, written by a diverse panel of experts, presents a description of the most relevant aspects of the epidemiology, diagnosis, local treatment, prognostic biomarkers and treatment for advanced disease, including the most recent research on novel molecules that are either approved or are undergoing clinical development. It includes insights on such challenging topics as when immunotherapy should be started in BRAF mutant patients, or which is the most appropriate treatment algorithm in those cases, as well as how to handle difficult and poor-prognosis melanoma cases, such as patients with brain metastases or patients with the uveal disease.
    Keywords: immunotherapy ; targeted therapy ; histopathology ; cancer ; radiotherapy ; immune checkpoint inhibitors ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 20
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.
    Keywords: biomarkers, immunotherapy, chemotherapy, melanoma, targeted therapy, squamous cell carcinoma ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 21
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Hepatocellular carcinoma (HCC) is a common tumor type arising from several distinct etiologies. It is usually diagnosed late and is difficult to treat. This volume presents an overview of selected aspects of HCC pathogenesis, and research aimed at developing diagnostic biomarkers. It points to a number of putative therapeutic targets, including signal transduction pathways, metabolic and epigenetic alterations in tumor cells, the tumor microenvironment, the gut microbiome, and functions of immune effector cells. Given the multi-step nature of most cancers, including HCC, future drug development will most likely require combination therapies that will simultaneously target multiple steps in hepatocarcinogenesis.
    Keywords: hepatocellular carcinoma ; liver cirrhosis ; inflammation ; biomarkers ; immunotherapy ; gene expression ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 22
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects.
    Keywords: immunotherapy, doxorubicin, cancer immunotherapy, cancer, optimization, nanoparticles ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 23
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.
    Keywords: cytokines, pathogenesis, micrornas, dendritic cells, behçet’s disease, vasculitis ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 24
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.
    Keywords: hematopoietic stem cell transplantation, monoclonal antibodies, novel therapies, epidemiology, risk factors, angiogenesis ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 25
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book aims to foster collaboration between world-class bench scientists and clinicians in the fields of oncology, surgery, and pathology as they come together to highlight the complexity and diversity of soft tissue tumors as well as recent advances in their diagnosis and clinical management.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 26
    Publication Date: 2024-03-31
    Description: The aim of this book is to provide an overview of the importance of exosomes in the biomedical field, which involves in novel implications of exosomes in diagnosis and treatment of cancer and infectious diseases. The book would definitely be an ideal source of scientific information of exosomes to researchers and scientists involved in biomedicine, biology, and other areas involving cancer and infectious diseases.
    Keywords: biomarkers, extracellular vesicles, pathogenesis, multiple myeloma, liquid biopsy, endothelial cells ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 27
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.
    Keywords: minimally invasive surgery, robotic surgery, immunotherapy, radiotherapy, mirna, liquid biopsy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 28
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Cancer mortality and morbidity are primarily brought on by metastasis. The ability of neoplastic cells to spread and colonize distant tissues is their most dangerous trait. Most malignancies are curable when they are detected early and have not spread outside of the original tissue. However, cancer is frequently incurable when tumor cells have created colonies elsewhere. Thus, the book content This book provides comprehensive information on cancer metastasis, along with references to specific cancer cases. The topics discussed include invasion by perturbation of cell-cell and cell-matrix adhesion, matrix degradation, motility, intravasation, extravasation, metastatic colonization, metastasis and angiogenesis. Molecular mechanisms, the metastatic process, and palliative bone metastasis therapy are also considered.
    Keywords: breast cancer ; immunotherapy ; epigenetics ; lung cancer ; extracellular vesicles ; targeted therapy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 29
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance development to current therapies, among others. Together with advances in the understanding of molecular features, factors, and mechanisms involved in initiation and tumor progression, important improvements have occurred in diagnostics and therapeutics in the shape of advances in molecular genotyping, procedures for sampling, new potential, and less invasive sources of samples for the diagnosis and development of new targeted therapies. The aim of this book is to provide an exciting read on strategies in the diagnosis and therapy of lung cancer.
    Keywords: immunotherapy, biomarker, metabolomics, epigenetic, cancer stem cells, methylation ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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  • 30
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    Radboud University Press
    Publication Date: 2024-03-29
    Description: Morbidity in primary care' is a medical textbook that presents a selection of diseases, disorders and clusters of symptoms registered in 'Family Medicine Network' (FaMe-Net). FaMe-Net is a Dutch primary care registration network with decades of experience in the accurate registration of all morbidity presented to the GP. This registration is embedded in the daily practice of GPs providing regular care to their enrolled patients. All morbidity data from 2014 up to and including 2021 can be accessed at www.famenet.nl/morbidity-data. Each chapter presents the incidence and prevalence of the selected condition and the age and sex groups in which this condition is most common. Common reasons for encounter are described: symptoms, complaints or requests that patients present to their GP at the beginning of the episode of care. In addition, each chapter discusses common GP interventions (policy). The clinical course and registration of the condition are also described. Reading the chapters in this book familiarises the user with how epidemiological numbers can be found on the website. The chapters contain links to the web pages where the relevant data are displayed. This makes it an interactive textbook, as the user can apply their own selections and look up their own epidemiological question. For example, change the calendar period or answer the same question for a different condition, including conditions not yet described in this book. The accompanying text in the chapters helps interpret the numbers correctly and guard against potential pitfalls. This book is thus dynamically linked to the website. The topics have been carefully selected and present epidemiological data of both brief episodic and chronic conditions, harmless and more serious conditions, and also include so-called symptom diagnoses that occur regularly in primary care, such as 'sleep disorders'. The database and this book are updated periodically. The FaMe-Net registration network is unique in systematically recording the patient's reason for encounter in every contact with the GP (practice), and the interventions carried out, such as radiology/imaging, laboratory diagnostics, prescription of medication and referrals to primary and secondary care. This allows the correlation between reason for encounter, final diagnosis and interventions to be visualised. This book is written by general practitioners practising in registering practices, many of whom are also affiliated with Radboud University Medical Centre as researchers, lecturers or trainers. The book is intended for general practitioners, GPs in training, medical students and researchers.
    Keywords: Complaints; Family medicine; General practice; Symptoms; Primary care; Prognosis; Diseases; Practice Based Research Network; Epidemiology ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKS Social welfare & social services::JKSG Care of the elderly ; bic Book Industry Communication::V Health & personal development::VF Family & health ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPC General practice ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJX Geriatric medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCJ Infectious & contagious diseases::MJCJ3 Hospital infections ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJW Paediatric medicine ; bic Book Industry Communication::V Health & personal development::VF Family & health::VFX Advice on parenting::VFXC Child care & upbringing ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMH Psychiatry ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSG Care of the elderly ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPC General practice / Family medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKN Geriatric medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases::MJCJ3 Hospital-acquired infections ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPK Mental health services ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKD Paediatric medicine ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFX Parenting: advice and issues::VFXC Child care and upbringing: advice for parents ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKL Psychiatry ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: The aim of this second Eng Special Issue is to collect experimental and theoretical re-search relating to engineering science and technology. The general topics of Eng are as follows: electrical, electronic and information engineering; chemical and materials engineering; energy engineering; mechanical and automotive engineering; industrial and manufacturing engineering; civil and structural engineering; aerospace engineering; biomedical engineering; geotechnical engineering and engineering geology; and ocean and environmental engineering. Therefore, the following editorial is a selection of representative works of these topics.
    Keywords: &nbsp ; Environment Management ; Environmental Engineering ; Chemical Engineering ; Materials Engineering&nbsp ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Human life relies on two basic supplies from nature: oxygen and food. Oxygen can be utilized directly, but food has to go through a process of digestion to become usable nutrients. The esophagus represents the beginning of this long journey. Because of its critical location, esophageal cancer is one of the deadliest malignancies in the world, and furthermore its incidence has been rising steadily year after year while other cancers are declining. It is predicted that by the year 2035 the esophageal cancer population will increase by 77.4% and become one of top global concerns. This book covers many aspects of esophageal cancer, through which we hope to raise the awareness of professionals as well as non-professionals about this disease.
    Keywords: immunotherapy, regenerative medicine, tumor microenvironment, gerd, laryngectomy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: In this book the reader will find a collection of chapters written by different research teams describing different aspects of peripheral T-cell lymphoma pathobiology, classification, and treatment. This work is mainly addressed to researchers already working in this area, but it is also accessible to anyone with a scientific background who desires to have an updated overview of the recent progress in this domain. It will also be valuable to scientists and physicians who have become newly involved in this field. Each chapter is self-contained and can be read independently of the others. This book intends to provide highlights of the current research as well as the current gold standards for diagnosis and treatment of these diseases, showing the recent advances in the personalized approach to T-cell derived lymphomas.
    Keywords: epigenetics, genomics, targeted therapy, precision medicine, transcriptomics, tyrosine kinase inhibitors ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Colorectal cancer is the third most common cancer diagnosed in both men and women worldwide. This book examines state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. It emphasizes the importance of a multidisciplinary approach involving multiple specialties, including surgery, gastroenterology, radiology, biology, oncology, radiotherapy, nuclear medicine, and physiotherapy.
    Keywords: colon cancer, immunotherapy, mri, targeted therapy, mortality, imaging ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.
    Keywords: epigenetics, biomarker, mass spectrometry, proteomics, dna methylation, personalized medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Neoplasm refers to an abnormal tissue growth that arises as a consequence of rapid cell proliferation and continues to grow abnormally even after terminating the stimuli that had instigated the change. It lacks partial or complete functional coordination with that of the normal tissues. Neoplasms are classified depending on the degree and type of tissues involved. Carcinogenesis is a multistep process where a plethora of endogenous and exogenous factors turns out genetic and epigenetic modifications, which collectively amend some critical cellular pathways controlling the proliferation, apoptosis, and differentiation. The cells having aberrant modifications are transformed into malignant ones of which the clonal expansion results in the development of cancer. This book provides the reader with a comprehensive overview of various cancer types along with their molecular mechanisms of initiation and progression. It also describes the current knowledge about the state-of-the-art measures being employed in cancer diagnosis and therapeutics. Particular attention is paid to make this book equally useful for students, practitioners, and expert scientists.
    Keywords: cancer, biomarkers, immunotherapy, surgery, chemotherapy, metabolism ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Springer Nature | Springer International Publishing
    Publication Date: 2024-04-01
    Description: This open access book provides basic concepts on Integrated Diagnostics and Theranostics with special emphasis on different human thyroid diseases. Thyroid diseases are increasingly detected (incidentally in many cases) but are clinically negligible in a significant proportion of patients. Accordingly, it is urgent to move from the simple disease detection to a reliable disease characterization in order to concentrate efforts on patients in need of tailored disease management. The current scenario of in vitro and in vivo diagnostics, is fastly moving toward the Integrated Diagnostics (i.e. convergence of imaging, pathology and laboratory tests with advanced information technology). Furthermore, the integration of different information will aid clinicians to properly select treatments and stratify patients’ prognosis over time. Theranostics is a perfect paradigm of such integrated approach and radioiodine, indicated for benign and malignant thyroid disease management, was the first and is still the mostly used theranostic agent in medicine. Featuring basics concepts and clinical cases discussions the Atlas will be an invaluable tool for clinicians, laboratory specialists, imaging physicians and biomedical technologists involved in diagnosis and therapy of thyroid diseases.
    Keywords: Thyroid and Parathyroid Tumours ; Neuroendocrine Tumours ; Adrenal Tumours ; Integrated Diagnostics ; Theragnostics ; Artificial Intelligence ; Big Data Analysis ; Molecular Imaging ; Radiomics ; Biomarkers ; Liquid biopsy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKR Nuclear medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: This Special Issue covers a well-balanced collection of state-of-the-art topics in the prospering and competitive field of anticancer drug design and development, which can address and inspire oncologists, biologists, and medicinal chemists among the readership of this journal.
    Keywords: illudin M ; retinoic acid ; neuronal cells ; brain tumors ; anticancer agents ; PROTAC ; target protein ; protein degradation ; indication ; cinnamic acid derivatives ; antiproliferative activity ; microtubule ; tubulin stabilizer ; pterostilbene ; melanoma ; anticancer activity ; apoptosis ; proliferation ; hepatocellular carcinoma ; eIF4A1 ; translation inhibitors ; targeted therapies ; heat shock proteins ; Hsp70 ; Hsp40 ; anticancer ; eEF1A ; mechanism ; macrocycle ; heterocycle ; gold ; carbene ligands ; metal-based drugs ; esophageal cancer ; carbonic anhydrases ; colorectal cancer ; consensus molecular subtypes ; CMS ; SLC-0111 ; targeted inhibition of carbonic anhydrases ; chemotherapy ; curcumin ; difluorinated curcumin ; CDF ; pancreatic cancer ; PDAC ; 2-hydroxypropyl-β-cyclodextrin ; cyclodextrin ; adenosine deaminases acting on RNA (ADAR) ; anti-ADAR2 ; natural products ; cancer ; depression ; anxiety disorders ; autism spectrum disorder (ASD) ; molecular docking ; molecular dynamics simulation ; n/a ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: This reprint contains five original research papers and eight review articles for the Special Issue "Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components" which is guest edited by Prof. Dr. Anupam Bishayee. There is one item that indicated the correction of one review.
    Keywords: gastric cancer ; bioactive food components ; autophagy ; apoptosis ; angiogenesis ; metastasis ; chemo-resistance ; broccoli ; isothiocyanates ; sulforaphane ; cancer ; prevention ; intervention ; molecular mechanisms ; beta-caryophyllene ; cannabinoid receptor 2 ; multiple myeloma ; Wnt/β-catenin ; Nelumbo nucifera ; phytochemicals ; therapeutic benefits ; n/a ; breast cancer stem cells ; dietary phytochemical ; luminal A subtype ; signaling pathway ; cancer prevention ; therapeutic resistance ; prostate cancer ; green tea catechins ; microbiome ; chemoprevention ; inositol hexaphosphate ; cancer stem cells ; TRAMP ; anti-inflammation ; anti-carcinogenicity ; gut microbiota ; Riceberry ; rice bran oil ; short-chain fatty acids ; chemotherapy ; drugs resistance ; dietary phenolic compounds ; drugs sensibilization ; combination treatment ; castration-resistant prostate cancer ; polygodial ; taxane-resistant CRPC ; anoikis ; natural products ; dietary spices ; colorectal cancer ; gnetin C ; diet supplementation ; transgenic mice ; targeted interception ; MTA1 ; phenolic compounds ; treatment ; in vivo ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book includes useful and recent information to the readers regarding the following topics: Signs and symptoms and etiology and risk factors of head and neck cancer, Epidemiology and the role of microRNAs in nasopharyngeal carcinoma and oral carcinogenesis, History, classifications, and managements of salivary gland cancer, Considerations, classifications, and managements of thyroid gland cancer, Updates in the diagnosis and management of medullary thyroid carcinoma, Interventional techniques used for the relief of head and neck cancer pain, Oral side effects of head and neck irradiation, Health-related quality of life in maxillectomy patients rehabilitated with obturator prostheses
    Keywords: epidemiology, biomarker, chemotherapy, radiotherapy, micrornas, carcinoma ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and anticancer activity of protein kinase inhibitors on various cancer types. They also discuss new opportunities, challenges, and future perspectives in the field.
    Keywords: toxicity, targeted therapy, drug resistance, clustering, inhibitor, cancer therapy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book is a feast of knowledge, yet a balanced diet of healthy foods. There are high values of rich essential nutrients from top-quality medical research. But they are made easily digestible and absorbable, even by health care providers and planners, working in resource-limited settings, in all parts of the world, through social implications and community applications. All the chapters are value-added master pieces. The book would serve both as a scientific reference guide and a practical work manual. The authors, editor, and Intech publishers, together, are pleased to provide the readers a precious blend of scientific excellence and social relevance, for health empowerment, globally. We wish the readers great success, savoring science and sociology together.
    Keywords: cervical cancer, hpv, cancer, epidemiology, vaccine, colorectal cancer ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several chapters focus on the posttranscriptional modification of the proteins at the melanocyte cell surface, their role in tumorigenesis, and their potential as therapeutic targets. Specifically, extracellular modifications of integrins, glycosylation of cell surface proteins, and changes of cadherins are presented. In a very interesting approach, a potential to target the mitochondria of melanoma cells is investigated. In conclusion, this volume presents various aspects of human skin cancers, components of the large worldwide effort to combat and eradicate this growing health concern.
    Keywords: melanoma, glycosylation, epigenetics, metastasis, cytotoxicity, migration ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Brain tumors comprise a spectrum of histological patterns. Their presentation and management depend on their location, size, and grade of lesions. This book is a collection of high-quality research work from global experts on brain tumors, including meningiomas, and their treatment.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Oral cancer is a common disease with a high incidence of morbidity and mortality. Despite technological advancements in diagnosis and treatment, the five-year survival rate is low. Researchers worldwide are attempting to identify new and novel methods for early diagnosis and better treatment of oral cancer to improve survival rate and quality of life post recovery. This book examines current concepts in oral cancer and emphasizes future perspectives for diagnosis and treatment of disease for better clinical outcomes and patient care.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Publication Date: 2024-04-03
    Description: This book presents an up to date ethical framework for radiological protection in medicine. It is consistent with the requirements of the system of radiation protection and with the expectations of medical ethics. It presents an approach rooted in the medical tradition, and alert to contemporary social expectations. It provides readers with a practical framework against which they can assess the safety and acceptability of medical procedures, including patients’ concerns. It will be an invaluable reference for radiologists, radiation oncologists, regulators, medical physicists, technologists, other practitioners, as well as academics, researchers and students of radiation protection in medicine. Features: An authoritative and accessible guide, authored by a team who have contributed to defining the area internationally Includes numerous practical examples/clinical scenarios that illustrate the approach, presenting a pragmatic approach, rather than dwelling on philosophical theories Informed by the latest developments in the thinking of international organizations
    Keywords: Dosimetry;Health physics;Medical ethics;Morality in medicine;Radiation dose;Radiation risk ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-05
    Description: The essential principles of green chemistry are the use of renewable raw materials, highly efficient catalysts and green solvents linked with energy efficiency and process optimization in real-time. Experts from different fields show, how to examine all levels from the molecular elementary steps up to the design and operation of an entire plant for developing novel and efficient production processes.
    Keywords: Process Engineering ; Chemical Engineering ; Technical Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNU Sustainability ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    White Rose University Press | White Rose University Press
    Publication Date: 2022-12-06
    Description: In Hidden Depths, Professor Penny Spikins explores how our emotional connections have shaped human ancestry. Focusing on three key transitions in human origins, Professor Spikins explains how the emotional capacities of our early ancestors evolved in response to ecological changes, much like similar changes in other social mammals. For each transition, dedicated chapters examine evolutionary pressures, responses in changes in human emotional capacities and the archaeological evidence for human social behaviours. Starting from our earliest origins, in Part One, Professor Spikins explores how after two million years ago, movement of human ancestors into a new ecological niche drove new types of collaboration, including care for vulnerable members of the group. Emotional adaptations lead to cognitive changes, as new connections based on compassion, generosity, trust and inclusion also changed our relationship to material things. Part Two explores a later key transition in human emotional capacities occurring after 300,000 years ago. At this time changes in social tolerance allowed ancestors of our own species to further reach out beyond their local group and care about distant allies, making human communities resilient to environmental changes. An increasingly close relationship to animals, and even to cherished possessions, appeared at this time, and can be explained through new human vulnerabilities and ways of seeking comfort and belonging. Lastly, Part Three focuses on the contrasts in emotional dispositions arising between ourselves and our close cousins, the Neanderthals. Neanderthals are revealed as equally caring yet emotionally different humans, who might, if things had been different, have been in our place today. This new narrative breaks away from traditional views of human evolution as exceptional or as a linear progression towards a more perfect form. Instead, our evolutionary history is situated within similar processes occurring in other mammals, and explained as one in which emotions, rather than ‘intellect’, were key to our evolutionary journey. Moreover, changes in emotional capacities and dispositions are seen as part of differing pathways each bringing strengths, weaknesses and compromises. These hidden depths provide an explanation for many of the emotional sensitivities and vulnerabilities which continue to influence our world today.
    Keywords: Human demography ; Group size ; Lithic transfers ; Raw material movements ; Bonobos ; Dog burial ; Comfort ; Symbolic objects ; Symbolism ; Mobiliary art ; Attachment fluidity ; Hypersociability ; Human-animal relationships ; Dog domestication ; Attachment object ; Approachability ; Approach behaviour ; Avoidance behaviour ; Androgens ; Physiological responses ; Cognitive Archaeology ; Autism Spectrum Condition ; Handaxe ; Biface ; Neurodiversity ; Palaeolithic stone tools ; Evolution of neurodiversity ; Rock art ; Ice age art ; Material Culture ; Cultural transmission ; Emotional commitment ; Biopsychosocial approach ; Social tolerance ; Attachment ; Genus Homo ; Acheulian ; Cultural evolution ; Skeletal abnormality ; Injury ; Illness ; Interdependence ; Emotional sensitivity ; Moral emotions ; Evolution of Altruism ; Hominins ; Upper Palaeolithic ; Lower Palaeolithic ; Ecological niche ; Selective pressure ; Behavioural ecology ; Wolves ; Affective empathy ; Cognitive empathy ; Theory of mind ; Human Cognition ; Vulnerability ; Evolutionary Psychology ; Developmental psychology ; Helping behaviours ; Social cognition ; Social mammals ; Human Emotion ; Human social collaboration ; Generosity ; Emotional brain ; Social emotions ; Comparative behaviour ; Evolution ; Social carnivores ; Primate behavioural ecology ; Primate social systems ; Human Evolution ; Human ancestors ; Collaboration ; Evolutionary Biology ; Emotional vulnerability ; Social connection ; Decolonisation ; Social networks ; Middle Palaeolithic ; Community resilience ; Convergent evolution ; Chimpanzee ; Origin of modern humans ; Social safeness ; Wolf domestication ; Cherished possessions ; Compensatory attachment ; Loneliness ; Palaeolithic art ; Stress reactivity ; Bonding hormones ; Humans ; Hunter-gatherers ; Intergroup collaboration ; Tolerance ; Emotional connection ; Autism ; Trust ; Early Prehistory ; Palaeopathology ; Origins of healthcare ; Human self-domestication ; Palaeolithic Archaeology ; Social brain ; Care-giving ; Empathy ; Neanderthals ; Compassion ; Social Connection ; Evolution of Emotions ; Human Origins ; Adaptation ; Prehistory ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology ; bic Book Industry Communication::H Humanities::HD Archaeology ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAJ Evolution ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPW Political activism::JPWQ Revolutionary groups & movements ; bic Book Industry Communication::J Society & social sciences::JM Psychology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: MicroRNAs are the best representatives of the non-coding part of the genome and their functions are mostly linked to their target genes. During the process of carcinogenesis, both dysregulation of microRNAs and their target genes can explain the development of the disease. However, most of the target genes of microRNAs have not yet been elucidated. In this book, we add new information related to the functions of microRNAs in various tumors and their associated targetome.
    Keywords: miR526b ; miR655 ; breast cancer ; angiogenesis ; lymphangiogenesis ; EP4 ; PI3K/Akt ; microRNA-361 ; EMT ; tumor microenvironment ; cancer diagnosis ; cancer treatment ; Bladder cancer ; microRNA ; genetic marker ; progression ; ccRCC ; prognostic biomarker ; miRNA ; transcription factor ; interplay ; microRNAs ; exosomes ; liquid biopsy ; metastasis ; cancer ; liquid biopsies ; tumor ; SNAIL (SNAI1) transcription factor ; epithelial to mesenchymal transition (EMT) ; long non-coding RNAs (lncRNAs) ; circular RNAs ; viral miRNAs ; EBV ; HHV-8 ; HPV ; HCV ; HBV ; MCPyV ; glioblastoma ; MGMT ; survival ; radiotherapy ; chemotherapy ; temozolomide ; translational medicine ; oncomiRNA ; post-transcriptional regulation ; immune regulation ; adrenocortical carcinoma ; micro RNA ; non-coding RNA ; thyroid carcinoma ; radioactive iodine ; drug resistance ; prognosis ; Burkitt lymphoma ; miR-378a-3p ; cell growth ; pancreatic cancer ; radioresistance ; personalized medicine ; biomarker ; target ; n/a ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Springer Nature | Springer International Publishing
    Publication Date: 2024-04-05
    Description: This open access book reflects on matters of social and ethical concern raised in the daily practices of those working in and around precision oncology. Each chapter addresses the experiences, concerns and issues at stake for people who work in settings where precision oncology is practiced, enacted, imagined or discussed. It subsequently discusses and analyses bioethical dilemmas, scientific challenges and economic trade-offs, the need for new policies, further technological innovation, social work, as well as phenomenological research. This volume takes a broad actor-centred perspective as, whenever cancer is present, the range of actors with issues at stake appears almost unlimited. This perspective and approach opens up the possibility for further in-depth and diverse questions, posed by the actors themselves, such as: How are cancer researchers navigating biological uncertainties? How do clinicians and policy-makers address ethical dilemmas around prioritisation of care? What are the patients’ experiences with, and hopes for, precision oncology? How do policy-makers and entrepreneurs envisage precision oncology? These questions are of great interest to a broad audience, including cancer researchers, oncologists, policy-makers, medical ethicists and philosophers, social scientists, patients and health economists.
    Keywords: cancer biomarkers ; Sociology of medicine ; Science and Technology Studies ; Oncology ; Philosophy of medicine ; precision oncology ; personalised cancer treatments ; health technology assessment ; Open access ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVJ Health economics
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    De Gruyter | De Gruyter Open Poland
    Publication Date: 2022-11-22
    Description: This edited volume examines the opportunities to think, do, and/or create jointly afforded by digital storytelling. The contributors discuss digital storytelling in the context of educational programs, teaching anthropology, and ethnographic research involving a variety of populations and subjects that will appeal to researchers and practitioners engaged with qualitative methods and pedagogies that rely on media technology.
    Keywords: Discourse ; Climate Change ; Humans ; Nature ; Oceania ; Resilience ; Environmental Ethics ; Environmental Change ; Worldview ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFC Social impact of disasters ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFH Popular beliefs & controversial knowledge::JFHF Folklore, myths & legends ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies::JFSL9 Indigenous peoples ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBD Population & demography ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSX Human biology::PSXM Medical anthropology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: A multidisciplinary understanding of the various processes leading to colorectal cancer progression is important for creating promising methods of therapy. Therefore it is necessary to scrutinize the progression of cancer and the therapeutic process through various academic theories. This book examines colorectal cancer - its prevention, pathogenesis, and treatment - through a multidisciplinary lens in an effort to advance understanding of the disease and improve therapeutic efficacy.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: “Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book provides an excellent overview of how melanoma is treated in the clinic. Since oncologists and clinicians across the globe contributed to this book, each area also explores the unique burdens that geographical areas experience from melanoma subtypes and how these are treated in different settings. It also includes several chapters that illustrate novel methods for diagnosing melanoma in the clinic using new technologies, which are likely to significantly improve outcomes. Several chapters cover surgical techniques and other present very rare or challenging clinical cases of melanoma and how these were treated. The book is geared towards informing clinicians and even patients how melanoma arises, what tools are available and which decisions need to be made by patients and their families in order to treat this devastating disease.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Hematology encompasses the physiology and pathology of blood and of the blood-forming organs. In common with other areas of medicine, the pace of change in hematology has been breathtaking over recent years. There are now many treatment options available to the modern hematologist and, happily, a greatly improved outlook for the vast majority of patients with blood disorders and malignancies. Improvements in the clinic reflect, and in many respects are driven by, advances in our scientific understanding of hematological processes under both normal and disease conditions. Hematology - Science and Practice consists of a selection of essays which aim to inform both specialist and non-specialist readers about some of the latest advances in hematology, in both laboratory and clinic.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Colorectal cancer is a common disease, affecting millions worldwide and represents a global health problem. Effective therapeutic solutions and control measures for the disease will come from the collective research efforts of clinicians and scientists worldwide. This book presents the current status of the strides being made to understand the fundamental scientific basis of colorectal cancer. It provides contributions from scientists, clinicians and investigators from 20 different countries. The four sections of this volume examine the evidence and data in relation to genes and various polymorphisms, tumor microenvironment and infections associated with colorectal cancer. An increasingly better appreciation of the complex inter-connected basic biology of colorectal cancer will translate into effective measures for management and treatment of the disease. Research scientists and investigators as well as clinicians searching for a good understanding of the disease will find this book useful.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Publication Date: 2024-03-31
    Description: This open access book is a step-by-step introduction on how shell scripting can help solve many of the data processing tasks that Health and Life specialists face everyday with minimal software dependencies. The examples presented in the book show how simple command line tools can be used and combined to retrieve data and text from web resources, to filter and mine literature, and to explore the semantics encoded in biomedical ontologies. To store data this book relies on open standard text file formats, such as TSV, CSV, XML, and OWL, that can be open by any text editor or spreadsheet application. The first two chapters, Introduction and Resources, provide a brief introduction to the shell scripting and describe popular data resources in Health and Life Sciences. The third chapter, Data Retrieval, starts by introducing a common data processing task that involves multiple data resources. Then, this chapter explains how to automate each step of that task by introducing the required commands line tools one by one. The fourth chapter, Text Processing, shows how to filter and analyze text by using simple string matching techniques and regular expressions. The last chapter, Semantic Processing, shows how XPath queries and shell scripting is able to process complex data, such as the graphs used to specify ontologies. Besides being almost immutable for more than four decades and being available in most of our personal computers, shell scripting is relatively easy to learn by Health and Life specialists as a sequence of independent commands. Comprehending them is like conducting a new laboratory protocol by testing and understanding its procedural steps and variables, and combining their intermediate results. Thus, this book is particularly relevant to Health and Life specialists or students that want to easily learn how to process data and text, and which in return may facilitate and inspire them to acquire deeper bioinformatics skills in the future.
    Keywords: Medicine ; Cancer research ; Human genetics ; Database management ; Data mining ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology ; thema EDItEUR::U Computing and Information Technology::UN Databases ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNF Data mining ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology ; thema EDItEUR::U Computing and Information Technology::UN Databases ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNF Data mining
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Cell adhesion ; matrix stiffness ; cancer cell invasion ; solid stress ; metastasis ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: Echolocation has evolved in different groups of animals, from bats and cetaceans to birds and humans, and enables localization and tracking of objects in a dynamic environment, where light levels may be very low or absent. Nature has shaped echolocation, an active sense that engages audiomotor feedback systems, which operates in diverse environments and situations. Echolocation production and perception vary across species, and signals are often adapted to the environment and task. In the last several decades, researchers have been studying the echolocation behavior of animals, both in the air and underwater, using different methodologies and perspectives. The result of these studies has led to rich knowledge on sound production mechanisms, directionality of the sound beam, signal design, echo reception and perception. Active control over echolocation signal production and the mechanisms for echo processing ultimately provide animals with an echoic scene or image of their surroundings. Sonar signal features directly influence the information available for the echolocating animal to perceive images of its environment. In many echolocating animals, the information processed through echoes elicits a reaction in motor systems, including adjustments in subsequent echolocation signals. We are interested in understanding how echolocating animals deal with different environments (e.g. clutter, light levels), tasks, distance to targets or objects, different prey types or other food sources, presence of conspecifics or certain predators, ambient and anthropogenic noise. In recent years, some researchers have presented new data on the origins of echolocation, which can provide a hint of its evolution. Theoreticians have addressed several issues that bear on echolocation systems, such as frequency or time resolution, target localization and beam-forming mechanisms. In this Research Topic we compiled recent work that elucidates how echolocation – from sound production, through echolocation signals to perception- has been shaped by nature functioning in different environments and situations. We strongly encouraged comparative approaches that would deepen our understanding of the processes comprising this active sense.
    Keywords: QP1-981 ; Q1-390 ; bats ; Biosonar ; Humans ; marine mammals ; sensory biology ; Birds ; Behavior ; Communication ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: The Frontiers in Chemistry Editorial Office team are delighted to present the inaugural “Frontiers in Chemistry: Rising Stars” article collection, showcasing the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers featured within this collection were individually nominated by the Journal’s Chief Editors in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of the chemical sciences, and presents advances in theory, experiment and methodology with applications to compelling problems. This Editorial features the corresponding author(s) of each paper published within this important collection, ordered by section alphabetically, highlighting them as the great researchers of the future. The Frontiers in Chemistry Editorial Office team would like to thank each researcher who contributed their work to this collection. We would also like to personally thank our Chief Editors for their exemplary leadership of this article collection; their strong support and passion for this important, community-driven collection has ensured its success and global impact.
    Keywords: Green and Sustainable Chemistry ; Analytical Chemistry ; Theoretical and Computational Chemistry ; Polymer Chemistry ; Medicinal and Pharmaceutical Chemistry ; Organic Chemistry ; Nanoscience ; Catalysis and Photocatalysis ; Supramolecular Chemistry ; Electrochemistry ; Inorganic Chemistry ; Chemical Biology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Stomach cancers are 90% adenocarcinoma; lymphoma, carcinoid, and stromal tumours may occur. Adenocarcinoma can be subdivided into histological Lauren and the World Health Organization (WHO) classifications, but this information has not led to the development of histologic subtype-specific treatment options. One way to potentially improve treatment for gastric cancers is to better understand the pathogenesis of this disease, the contribution of Helicobacter pylori infection, and host immune response to lead to the development of integrated histological and molecular classification schemes for gastric cancer. The hope is that these studies may facilitate the development of clinical trials to explore therapies in defined sets of patients, ultimately improving survival from this deadly disease.
    Keywords: RC254-282 ; pathogenesis ; prognostic marker ; gastric cancer ; Helicobacter pylori ; proteomics ; immune response ; genomics ; diagnostic marker ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: In spite of advances in the cancer research field, cancer treatment still challenges researchers and clinicians, as proven by the still impressive and increasing number of worldwide cancer-related deaths. Updates on Cancer Treatment is an attempt to integrate into a book volume various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book offers significant coverage on different aspects of cancer from risk factors to the mechanisms leading to tumor progression and metastasis. Although tremendous progress has been made in cancer research and treatment, cancer metastasis remains a major unmet clinical need. The life and death of many cancer patients hangs on the degree of metastasis. This book provides new perspectives for diagnosis and cancer therapy. It includes new technologies and a new basis for current cancer therapies. To guarantee the high quality of this book, important topics are included and rigorously discussed in a simple and authentic way. The book addresses important challenges governing tumor progression and metastasis and brings new responses to both diagnosis and therapy. This book is a great source of knowledge and will be useful for researchers, medical doctors, oncologists, graduate and medical students, continued medical educators, health care providers, and all individuals interested in understanding cancer and its challenges.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of every one of its many facets, the chapters from many investigators from around the world nevertheless cover a number of relevant topics: aspects of the epidemiology of ALL in Hispanics, ophthalmologic manifestations of ALL, overviews of current therapy and drug-resistance mechanisms, novel biological pathways and targets, new drugs in development, and long-term consequences of CNS prophylaxis and therapy. The publishers and editor therefore hope that the prospective readers will find enough insight and information for their own endeavors.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Soft tissue tumors include a heterogeneous group of diagnostic entities, most of them benign in nature and behavior. Malignant entities, soft tissue sarcomas, are rare tumors that account for1% of all malignancies. These are predominantly tumors of adults, but 15% arise in children and adolescents. The wide biological diversity of soft tissue tumors, combined with their high incidence and potential morbidity and mortality represent challenges to contemporary researches, both at the level of basic and clinical science. Determining whether a soft tissue mass is benign or malignant is vital for appropriate management. This book is the result of collaboration between several authors, experts in their fields; they succeeded in translating the complexity of soft tissue tumors and the diversity in the diagnosis and management of these tumors.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. It is an enormous global health encumbrance, growing at an alarming pace. Global statistics show that in 2030 alone, about 21.4 million new cancer cases and 13.2 million cancer deaths are expected to occur, simply due to the growth, aging of the population, adoption of new lifestyles and behaviors. Amongst the several modes of treatment for cancer available, Radiation treatment has a major impact due to technological advancement in recent times. This book discusses the pros and cons of this treatment modality. This book "Modern Practices in Radiation Therapy" has collaged topics contributed by top notch professionals and researchers all around the world.
    Keywords: Radiotherapy ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Multiple myeloma is a malignant disorder characterized by the proliferation of plasma cells. Much insight has been gained into the molecular pathways that lead to myeloma and indeed much more remains to be done. The understanding of these pathways is closely linked to their therapeutic implications and is stressed upon in the initial chapters. Recently, the introduction of newer agents such as bortezomib, lenalidomide, thalidomide, liposomal doxorubicin, etc. has led to a flurry of trials aimed at testing various combinations in order to improve survival. Higher response rates observed with these agents have led to their integration into induction therapies. The role of various new therapies vis a vis transplantation has also been examined. Recent advances in the management of plasmacytomas , renal dysfunction, dentistry as well as mobilization of stem cells in the context of myeloma have also found exclusive mention. Since brevity is the soul of wit our attempt has been to present before the reader a comprehensive yet brief text on this important subject.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: In the ancient past, cocoa has been appreciated as a high-calorie food to boost energy in soldiers and for its undefined medicinal and mystical properties. During other times, chocolate has been considered as the forbidden “food of God”: a treasure of pleasure for the mind and the soul. The overall perception of the consumer for chocolate was of a “charming” and appealing food with lots of negative aspects related to high sugar content leading to consider chocolate as “junk food” for its “obesigen” calories. Recently, in association with the renewed interest of nutrition science in alternative source of health-promoting foods and ingredients, a large body of research has been conducted to unravel the pro and cons of cocoa in relation to human health. Epidemiological evidences indicate that cocoa consumption helps preventing cardiovascular disease for its high content in bioactive flavonoids. Clinical trials show that chocolate consumption might improve vascular function, decreasing platelet aggregation and display an antioxidant and anti-inflammatory effect. The putative protective action of cocoa seems to be multi-factorial and involving different aspects of vascular, antioxidant and endothelial function. However, the mechanism(s) that account for the benefits of cocoa it is still unclear. The aim of this Research Topic is therefore to provide the reader with an objective picture of the state of art on the association between cocoa and health, mainly through the evidences of human trials; overwhelmingly considered the golden standard for nutritional science. The Research Topic will cover the analysis of the manufacturing processes of the chocolate and the antioxidant effects in humans as well as the majority of the putative health effects of chocolate and cocoa, such as anti-inflammatory properties, effect on immunity, platelet aggregation, blood pressure, endothelial function and cognitive behavior. Unraveling the functional properties of cocoa will help to understand if the 'food of God' is a primordial gift for the health of mankind.
    Keywords: R5-920 ; RC581-607 ; TX341-641 ; Antioxidants ; Obesity ; Flavonoids ; Humans ; Chocolate ; Blood pressure ; Inflammation ; Cognitive function ; Cocoa ; Immunity
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Prostate cancer is one of the most common types of cancer in men and its treatment was constricted to surgery for confined state and androgen ablation for advanced disease until new options have become available. The present book covers a broad range of novel aspects of prostate cancer diagnosis, treatment and patient care, as well as new research on relevant cell biology. In detail, this special volume focusses on supportive modalities for prostate cancer patients, appropriate selection of novel therapeutic regimens, including inhibitors of steroidal synthesis, cytotoxic agents, as well as intermittent androgen suppression and the roles of prostate cancer stem cells and inflammatory processes.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    Publication Date: 2024-03-31
    Description: Metastasis is the main cause of cancer patient mortality. Local tumor invasion is a key step in metastatic dissemination whereby cancer cells dislodge from primary tumors, migrate through the peritumoral stroma and reach the circulation. This is a highly dynamic process occurring in three dimensions that involves interactions between tumor, stromal cells, and the extracellular matrix. Here we describe the organotypic culture system and its utility to study breast cancer cell invasion induced by cancer-associated fibroblasts. This is a three-dimensional model that reproduces the biochemical and physiological properties of real tissue and allows for investigating the molecular and cellular mechanisms involving tumor and its microenvironment, and their contribution to cancer cell invasion. This system provides a robust, accurate, and reproducible method for measuring cancer cell invasion and represents a valuable tool to improve the mechanistic understanding of the initial steps in metastasis.
    Keywords: RC254-282 ; Cancer-associated fibroblasts ; Organotypic ; Breast cancer ; Metastasis ; Invasion ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book is oriented towards clinicians and scientists in the field of the management of patients with liver tumors. As many unresolved problems regarding primary and metastatic liver cancer still await investigation, I hope this book can serve as a tiny step on a long way that we need to run on the battlefield of liver tumors.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Hodgkin's Lymphoma is the book consisting of 11 chapters: Recent insights into the biology of Hodgkin's lymphoma, including historical aspects, epidemiology, pathophysiology, genetic defects, and prognostic indicators are explained in the intro chapters. After a translational chapter from tumor microenvironment to immunotherapeutic approach, treatment of early stage, advanced, and refractory Hodgkin's lymphoma are explained in the following chapters. MALT lymphoma and adverse effects of chemotherapy and radiotherapy in the affected patients are discussed in the subsequent chapters, while the final chapter is focused on survivorship in Hodgkin's lymphoma. The book is intended to present recent advances in the pathophysiology of Hodgkin's lymphoma as well as practical approach to diagnosis and management in clinical practice, which is hoped to be welcomed by the physicians, who wish to learn more about Hodgkin's lymphoma.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    Springer Nature | Springer
    Publication Date: 2024-04-01
    Description: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
    Keywords: Pharmacology/Toxicology ; Neurosciences ; Cardiology ; Oncology ; Pharmacology ; Neuroscience ; Internal Medicine ; reproducibility ; study design ; data analysis ; data reporting ; data integrity ; quality management ; open access ; Cardiovascular medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Cancer remains a major clinical challenge as a cause of death due to its frequent poor prognosis and limited treatment options in many cases. Cancer management book addresses various cancer management related topics including new approaches for early cancer detection and novel anti-cancer therapeutic strategies. This book is a collection of studies and reviews written by experts from different parts of the world to present the most up-to-date knowledge on cancer management.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 79
    Publication Date: 2024-03-31
    Description: Venous Thromboembolism remains a major health challenge in many countries because of the morbidity and mortality it inflicts, mainly in hospitalized patients. This book, with contributions from distinguished experts in the field, depicts some hot aspects on aetilogics of VTE, the disease burden in neonates, renal disease and cancer patients as well as issues relevant to prophylaxis and the concept of VTE as patient injury content.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 80
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    Springer Nature | Springer
    Publication Date: 2024-03-31
    Description: This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.
    Keywords: Cancer Research ; Cancer Metabolism ; Cancer Therapy ; Cancer Biology ; open access ; personalized cancer treatment ; glucose metabolism ; glutamine metabolism ; metabolism biomarkers ; metabolic pathways ; drug treatments ; glioblastoma ; pancreatic cancer ; breast cancer ; renal cell carcinoma ; non-hodgkin's lymphoma ; cancer-associated fibroblasts ; tumor microenvironment ; covid-19 ; diabetes ; cardiovascular diseases ; gene profiles ; chemotherapeutic agenet ; clinical trials ; Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 81
    Publication Date: 2024-04-05
    Description: This eBook comprises s series of original research and review articles dealing with the anatomical, genetic, and physiological organization of the auditory system from humans to monkeys and mice.
    Keywords: RC321-571 ; Q1-390 ; audition ; monkeys ; gens ; translational ; Humans ; Rodents ; Memory ; Perception ; Physiology ; functional imaging ; Anatomy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: The book Cancer of the Uterine Endometrium - Advances and Controversies brings together an international collaboration of authors who share their contributions for the management of endometrial carcinoma. The scope of the text is not basic, but rather aims to provide a comprehensive and updated source of advances in the diagnosis and therapeutic strategies in this field of gynecologic cancer. Each section in the book attempts to provide the most relevant evidence-based information in the biology and genetics, modern imaging, surgery and staging, and therapies for endometrial cancer. It is hoped that future editions will bring additional authors to contribute to this endeavor. To this end, it is our patients who will benefit from this work.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Cervical cancer is the second most prevalent cancer among women worldwide, and infection with Human Papilloma Virus (HPV) has been identified as the causal agent for this condition. The natural history of cervical cancer is characterized by slow disease progression, rendering the condition in essence preventable and even treatable when diagnosed in early stages. Pap smear and the recently introduced prophylactic vaccines are the most prominent prevention options, but despite the availability of these primary and secondary screening tools, the global burden of disease is unfortunately still very high This book will focus on the clinical and diagnostic aspects of HPV and related disease, highlighting the latest developments in this field.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 85
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 86
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 87
    Publication Date: 2024-03-31
    Description: Cutaneous malignant melanoma (CMM), which is ranked as the 8th most common cancers in the US, makes 4–7% of skin cancers but it causes approximately 80% of skin cancer deaths. CMM is characterized by insidious and fast progression, heterogenic evolution, and significant resistance to numerous therapeutic strategies. CMM is the result of the uncontrolled proliferation of melanocytes, the cells which reside in the basal layer of the epidermis. The most efficient therapy is the surgical removal if the lesion is in an early stage. For metastatic melanomas, there are different strategies, extremely rarely leading to total cure. Tyrosinase-related protein-2 (TRP2) or L-Dopachrome tautomerase (L-DCT) is a member of Tyrosinase-related protein family known for many years for its enzymatic activity in the distal steps of melanogenesis. The modern DCT image is focusing more on processes and mechanisms related to cell development and response to environmental and therapeutic stressors in normal and transformed cell phenotypes. This chapter provides an extended, updated biological status of TRP2/L-DCT encompassing the structural and functional particularities within melanoma molecularity, in the attempt to get new insights into the complex mechanisms of this neoplasm and raise the interest for DCT unexplored yet potential in melanoma diagnosis/prognosis and therapy.
    Keywords: tyrosinase-related protein-2, L-Dopachrome tautomerase, melanoma biomarker, structural molecular model, melanoma therapy, melanoma progression, caveolin-1, melanoma signaling pathways ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book encompasses three sections pertaining to the topics of cancer biology, diagnostic markers, and therapeutic novelties. It represents an essential resource for healthcare professionals and scientist dedicated to the field of prostate cancer research. This book is a celebration of the significant advances made within this field over the past decade, with the hopes that this is the stepping stone for the eradication of this potentially debilitating and/or fatal malignancy.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 89
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: This book brings together the knowledge of eminent experts in the field of malignant mesothelioma, a highly invasive tumor of mesothelium that is the protective lining covering several body cavities. Malignant mesothelioma shows extremely poor progression and is refractory to almost any kind of therapy putting considerable challenges in its treatment. This book covers many important aspects of malignant mesothelioma like epidemiology, immunology, molecular mechanisms and clinical options and will be useful to anybody interested in its history, pathology, and treatment.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: In this book entitled "Prostate Cancer - Diagnostic and Therapeutic Advances", we highlight many of the significant advances made in our treatment armamentarium of prostate cancer. The book is subdivided into four sections termed: 1) novel diagnostic approaches, 2) surgical treatments options, 3) radiation therapy and its potential sequelae, and 4) medical management and its treatment complications. After reading the present book , readers will be very familiar with the major clinical advances made in our multifaceted treatment approach to prostate cancer over the past decade.This book is a tribute to our pioneering urologists and allied healthcare professionals who have continually pushed forward our traditional therapeutic envelope.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Hepatocellular Carcinoma represents a leading cause of cancer death and a major health problem in developing countries where hepatitis B infection is prevalent. It has also become increasingly important with the increase in hepatitis C infection in developed countries. Knowledge of hepatocellular carcinoma has progressed rapidly. This book is a compendium of papers written by experts to present the most up-to-date knowledge on hepatocellular carcinoma. This book deals mainly with the basic research aspect of hepatocellular carcinoma. The book is divided into three sections: (I) Biomarkers / Therapeutic Target; (II) Carcinogenesis / Invasion / Metastasis; and (III) Detection / Prevention / Prevalence. There are 18 chapters in this book. This book is an important contribution to the basic research of hepatocellular carcinoma. The intended readers of this book are scientists and clinicians who are interested in research on hepatocellular carcinoma. Epidemiologists, pathologists, hospital administrators and drug manufacturers will also find this book useful.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Management of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on pathological classification and complex treatment algorithms for each common tumor type. Additional detailed information is provided on selected CNS tumor associated disorders.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Harnessing the potential of the human body's own immune system to attack malignant tumor cells has been the goal of many scientific investigators in recent years, with advances in cancer biology and immunology enabling cancer immunotherapy to become a reality. World-class bench and clinical researchers have joined forces to collaborate and review current developments and trends in cancer immunology for the purposes of this book, and the result is a promising review of contemporary clinical treatments. In each chapter the authors present the scientific basis behind such therapeutic approaches, including cancer vaccines with special focus on prostate cancer, melanoma and novel approaches utilizing both innate and adaptive immune responses.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Cancer Stem Cells Theories and Practice does not 'boldly go where no one has gone before!' Rather, Cancer Stem Cells Theories and Practice boldly goes where the cutting edge of research theory meets the concrete challenges of clinical practice. Cancer Stem Cells Theories and Practice is firmly grounded in the latest results on cancer stem cells (CSCs) from world-class cancer research laboratories, but its twenty-two chapters also tease apart cancer's vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Head and Neck Cancer provides an interesting and comprehensive overview of all aspects of head and neck cancer including overviews of the disease, basic science aspects pertaining to the disease, diagnosis, treatment and outcomes for patients with this disease. The chapters written by world renowned experts cover the entire discipline of head and neck oncology and include discussions of regional disparity is, advances in basic science understanding, advances in her radiotherapy, chemotherapy and targeted agents as well as a focus on reconstruction, prostheses, and aspects of quality of life and health outcomes. The book is designed to be both practical and comprehensive for every physician treating his complex disease.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 96
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Oral cancer is a significant public health challenge globally. Although the oral cavity is easily accessible, early diagnosis remains slow compared to the enhanced detection of cancers of the breast, colon, prostate, and melanoma. As a result, the mortality rate from oral cancer for the past four decades has remained high at over 50% in spite of advances in treatment modalities. This contrasts with considerable decrease in mortality rates for cancers of the breast, colon, prostate, and melanoma during the same period. This book attempts to provide a reference-friendly update on the etiologic/risk factors, current clinical diagnostic tools, management philosophies, molecular biomarkers, and progression indicators of oral cancer.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Mesothelioma is an aggressive cancer with very poor survival and lack of treatment options. This book, written by a diverse panel of experts, presents a description of the most relevant topics on epidemiology, diagnosis, biomarkers, and treatment updates, including interesting discussion on molecular mechanisms, prognostic features, and novel therapies that are either approved or under clinical development for this challenging disease. It also discusses and explains genetic biomarkers, as there may be a role for some nuclear regulatory genes and proteins in development of mesothelioma, although targeted therapies so far have had limited impact.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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  • 98
    Publication Date: 2024-03-31
    Description: Diseases & disorders
    Keywords: Medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: The book "Advances in Cancer Therapy" is a new addition to the Intech collection of books and aims at providing scientists and clinicians with a comprehensive overview of the state of current knowledge and latest research findings in the area of cancer therapy. For this purpose research articles, clinical investigations and review papers that are thought to improve the readers' understanding of cancer therapy developments and/or to keep them up to date with the most recent advances in this field have been included in this book. With cancer being one of the most serious diseases of our times, I am confident that this book will meet the patients', physicians' and researchers' needs.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-03-31
    Description: Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.
    Keywords: Oncology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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