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  • Biochemistry and Biotechnology  (13,095)
  • JFC
  • 1
    Publication Date: 2024-01-18
    Description: Turkic World studies seem to be a topic that attracts scientific attention day by day. The continuous increase in cooperation, rapprochement, and mobility between Turkish-speaking countries and communities since 1991 might be shown as the main dynamic behind this interest. The richness of the Turkic Republics in terms of natural resources, their location on the energy and transportation corridors, the change of the balances in the Caucasus with the Second Karabakh War in 2020, and the transition of the Turkic Council from a cooperation organization to an interstate organization in 2021 under the name of the "Organization of Turkic States" also accelerate the work of the Turkic World. In the meantime, the popularization of some geopolitical determinations and predictions in the context of scientific interest in the region can be shown as an important factor. Similar to the rise of Europe in the industrial age, we can talk about the rise of Asia in the information age. The sources of political and economic power are shifting to Asian geopolitics and this process continues to strengthen. Such analyses and predictions, which bring to the agenda that in the 2050s, Asia will regain its former central position also encourage academic interest in Central Asia. This book is the product of the goal of creating an original work for the Turkish World with gap-filling parameters and process analyses determined by a meticulous preliminary study in the light of the mentioned background. In this direction, three basic perspectives such as the effort to determine the capacities of the countries with comparative analyses, to look at the Turkish World from the perspective of problems, and to embody the Turkish World based on the community, autonomous region, and country sections dominate the work. With comparative analyses, it has been tried to embody the capacities of the countries within the parameters such as sustainable development potential, transportation systems, scientific performance, evolution in the political system, education system, and values of education. On the other hand, the crises affecting the Turkic World were discussed with the analysis of Karabakh, which is the main crisis, and the Russia-Ukraine War, which is the current crisis. On the other hand, the analysis of the thirty-year process in the Turkish World, starting from the scales of the community, autonomous region, and country, was carried out through the examples of Georgia, Tatarstan, and Uzbekistan.
    Description: Published
    Description: Türk Dünyası çalışmaları bilimsel ilgiyi giderek üzerine çeken bir konu başlığı görünümündedir. Bu ilginin arka planında yer alan başlıca dinamik olarak, Türkçe konuşan ülke ve topluluklar arasında 1991 yılından bugüne; iş birliği, yakınlaşma ve mobilitedeki sürekli artış gösterilebilir. Türk Cumhuriyetlerinin doğal kaynaklar bakımından zengin olması, aynı zamanda enerji ve ulaşım koridorları üzerinde yer almaları, 2020’deki İkinci Karabağ Savaşıyla Kafkasya’daki dengelerin değişmesi ve Türk Konseyi’nin 2021 yılında “Türk Devletleri Teşkilatı” adını alarak bir iş birliği örgütünden devletlerarası teşkilata geçiş süreci içine girmesi gibi gelişmeler de Türk Dünyası çalışmalarına ivme kazandırmaktadır. Bu arada bölgeye olan bilimsel ilgi bağlamında bazı jeopolitik tespit ve öngörülerin popülerleşmesinden de bahsedilebilir. Buna göre sanayi çağında Avrupa’nın yükselişine benzer bir şekilde bilgi çağında da Asya’nın yükselişi söz konusudur. Politik ve ekonomik güç kaynakları Asya jeopolitiğine kaymakta ve bu süreç güçlenerek devam etmektedir. Asya’nın 2050’li yıllarda eski merkezi konumuna tekrar ulaşacağını gündeme taşıyan bu tarz analiz ve öngörüler Orta Asya’ya yönelik akademik ilgiyi de teşvik edici niteliktedir. Bu kitap bahsedilen arka planın ışığı altında, titiz bir ön çalışmayla belirlenen boşluk doldurucu parametreler ve süreç analizleriyle Türk Dünyasına yönelik özgün bir eser oluşturma hedefinin ürünüdür. Bu doğrultuda; karşılaştırmalı analizlerle ülke kapasitelerini belirleme çabası, Türk Dünyasına sorunlar penceresinden bakma ve yine Türk Dünyasını topluluk, özerk bölge ve ülke kesitlerinden hareketle somutlaştırma gibi üç temel bakış açısı esere hâkimdir. Karşılaştırmalı analizlerle ülke kapasitelerini somutlaştırma; sürdürülebilir kalkınma potansiyeli, ulaşım sistemleri, bilimsel performans, siyasal sistemdeki evrim, eğitim sistemi ve değerler eğitimi gibi parametreler dâhilinde gerçekleştirilmeye çalışılmıştır. Türk Dünyasını etkileyen krizler ise; başlıca kriz konumunda olan Karabağ ve güncel kriz olan Rusya-Ukrayna Savaşına yönelik analizlerle ele alınmıştır. Türk Dünyasındaki otuz yıllık sürece topluluk, özerk bölge ve ülke ölçeklerinden hareketle göz atma ise; Gürcistan, Tataristan ve Özbekistan örnekleri üzerinden gerçekleştirilmiştir.
    Keywords: Turkic World ; JFC
    Language: Turkish
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  • 2
    Publication Date: 2023-12-17
    Description: Turkic World studies seem to be a topic that attracts scientific attention day by day. The continuous increase in cooperation, rapprochement, and mobility between Turkish-speaking countries and communities since 1991 might be shown as the main dynamic behind this interest. The richness of the Turkic Republics in terms of natural resources, their location on the energy and transportation corridors, the change of the balances in the Caucasus with the Second Karabakh War in 2020, and the transition of the Turkic Council from a cooperation organization to an interstate organization in 2021 under the name of the "Organization of Turkic States" also accelerate the work of the Turkic World. In the meantime, the popularization of some geopolitical determinations and predictions in the context of scientific interest in the region can be shown as an important factor. Similar to the rise of Europe in the industrial age, we can talk about the rise of Asia in the information age. The sources of political and economic power are shifting to Asian geopolitics and this process continues to strengthen. Such analyses and predictions, which bring to the agenda that in the 2050s, Asia will regain its former central position also encourage academic interest in Central Asia. This book is the product of the goal of creating an original work for the Turkish World with gap-filling parameters and process analyses determined by a meticulous preliminary study in the light of the mentioned background. In this direction, three basic perspectives such as the effort to determine the capacities of the countries with comparative analyses, to look at the Turkish World from the perspective of problems, and to embody the Turkish World based on the community, autonomous region, and country sections dominate the work. With comparative analyses, it has been tried to embody the capacities of the countries within the parameters such as sustainable development potential, transportation systems, scientific performance, evolution in the political system, education system, and values of education. On the other hand, the crises affecting the Turkic World were discussed with the analysis of Karabakh, which is the main crisis, and the Russia-Ukraine War, which is the current crisis. On the other hand, the analysis of the thirty-year process in the Turkish World, starting from the scales of the community, autonomous region, and country, was carried out through the examples of Georgia, Tatarstan, and Uzbekistan.
    Description: Published
    Description: Türk Dünyası çalışmaları bilimsel ilgiyi giderek üzerine çeken bir konu başlığı görünümündedir. Bu ilginin arka planında yer alan başlıca dinamik olarak, Türkçe konuşan ülke ve topluluklar arasında 1991 yılından bugüne; iş birliği, yakınlaşma ve mobilitedeki sürekli artış gösterilebilir. Türk Cumhuriyetlerinin doğal kaynaklar bakımından zengin olması, aynı zamanda enerji ve ulaşım koridorları üzerinde yer almaları, 2020’deki İkinci Karabağ Savaşıyla Kafkasya’daki dengelerin değişmesi ve Türk Konseyi’nin 2021 yılında “Türk Devletleri Teşkilatı” adını alarak bir iş birliği örgütünden devletlerarası teşkilata geçiş süreci içine girmesi gibi gelişmeler de Türk Dünyası çalışmalarına ivme kazandırmaktadır. Bu arada bölgeye olan bilimsel ilgi bağlamında bazı jeopolitik tespit ve öngörülerin popülerleşmesinden de bahsedilebilir. Buna göre sanayi çağında Avrupa’nın yükselişine benzer bir şekilde bilgi çağında da Asya’nın yükselişi söz konusudur. Politik ve ekonomik güç kaynakları Asya jeopolitiğine kaymakta ve bu süreç güçlenerek devam etmektedir. Asya’nın 2050’li yıllarda eski merkezi konumuna tekrar ulaşacağını gündeme taşıyan bu tarz analiz ve öngörüler Orta Asya’ya yönelik akademik ilgiyi de teşvik edici niteliktedir. Bu kitap bahsedilen arka planın ışığı altında, titiz bir ön çalışmayla belirlenen boşluk doldurucu parametreler ve süreç analizleriyle Türk Dünyasına yönelik özgün bir eser oluşturma hedefinin ürünüdür. Bu doğrultuda; karşılaştırmalı analizlerle ülke kapasitelerini belirleme çabası, Türk Dünyasına sorunlar penceresinden bakma ve yine Türk Dünyasını topluluk, özerk bölge ve ülke kesitlerinden hareketle somutlaştırma gibi üç temel bakış açısı esere hâkimdir. Karşılaştırmalı analizlerle ülke kapasitelerini somutlaştırma; sürdürülebilir kalkınma potansiyeli, ulaşım sistemleri, bilimsel performans, siyasal sistemdeki evrim, eğitim sistemi ve değerler eğitimi gibi parametreler dâhilinde gerçekleştirilmeye çalışılmıştır. Türk Dünyasını etkileyen krizler ise; başlıca kriz konumunda olan Karabağ ve güncel kriz olan Rusya-Ukrayna Savaşına yönelik analizlerle ele alınmıştır. Türk Dünyasındaki otuz yıllık sürece topluluk, özerk bölge ve ülke ölçeklerinden hareketle göz atma ise; Gürcistan, Tataristan ve Özbekistan örnekleri üzerinden gerçekleştirilmiştir.
    Keywords: Turkic World ; JFC
    Language: Turkish
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  • 3
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    Edward Elgar Publishing | Edward Elgar Publishing
    Publication Date: 2023-03-21
    Description: Academic literature on cultural districts has skyrocketed. In parallel, the development of cultural districts has become a standard practice in policy-making worldwide at different scales. Government bodies have used cultural districts policies to regenerate and rebrand urban areas, sometimes focusing on increasing cultural consumption, other times fostering innovation and entrepreneurship. This chapter first provides a definition of cultural district and discusses its roots in the Marshallian industrial district. Secondly, it looks at the agglomeration economies that firms, organizations and individuals enjoy because they are not only co-located in the same area but highly interconnected among each other. In conclusion, the study of cultural districts offers a challenging and fertile ground to advance theories on cultural industries and urban development while re-affirming the importance of intense face-to-face interaction and spatial proximity in the production, distribution and consumption of cultural goods and services.
    Description: Published
    Keywords: Economics ; culture ; arts ; creative industries ; digitization ; copyright ; JFC ; KCK ; GBC
    Language: English
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  • 4
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    Nomos Verlagsgesellschaft mbH & Co. KG | Rombach Verlag
    Publication Date: 2023-07-10
    Description: By applying the theoretical concepts of ‘discourse’ and ‘mental schema’ to textual analysis, the author presents an innovative analysis of important Spanish novels and essays from the recent past, focusing on the relationship between literary text and collective knowledge. Considering aspects such as power, memory, modernisation, etc., he brings to light contextual references between literary and non-literary contemporary texts and consequent correlations between literary and social developments. This volume is aimed primarily at literary and cultural scholars. Horst Rien, born in 1948, is a Romance scholar who has taught at the universities of Göttingen and Hamburg. His research focuses on Spanish and French literature from the 18th and 20th centuries.
    Description: Published
    Description: Mit Hilfe einer textanalytischen Anwendung der theoretischen Konzepte „Diskurs“ und „mentales Schema“ legt der Autor eine innovative Analyse wichtiger spanischer Romane und Essays der jüngeren Vergangenheit vor, die sich auf die Beziehung zwischen literarischem Text und kollektivem Wissen konzentriert. Unter Gesichtspunkten wie Macht, Erinnerung, Modernisierung etc. werden kontextuelle Bezüge zwischen literarischen und nicht-literarischen, zeitgenössischen Texten und damit Korrelationen zwischen literarischen und gesellschaftlichen Entwicklungen sichtbar gemacht. Der Band richtet sich vor allem an Literatur- und Kulturwissenschaftler:innen. Horst Rien, geb. 1948, hat als Romanist an den Universitäten Göttingen und Hamburg unterrichtet. Seine Forschungsschwerpunkte liegen auf der spanischen und französischen Literatur des 18. und 20. Jahrhunderts.
    Keywords: 20. Jahrhundert ; Diskurs ; französische Literatur ; Korrelationen ; Kulturwissenschaft ; Macht ; Modernisierung ; Romanistik ; spanische Literatur ; zeitgenössische Texte ; DNF ; DSK ; DSBH ; JFC ; 2ACG ; 2ADS
    Language: German
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 57 (1998), S. 590-599 
    ISSN: 0006-3592
    Keywords: protein refolding ; hollow-fibre membrane ; dialysis ; carbonic anhydrase ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: We have used a cellulose acetate, hollow-fibre (HF) ultrafiltration membrane to refold bovine carbonic anhydrase, loaded into the lumen space, by removing the denaturant through controlled dialysis via the shell side space. When challenged with GdnHCl-denatured carbonic anhydrase, 70% of the loaded protein reptated through the membrane into the circulating dialysis buffer. Reptation occurred because the protein, in its fully unfolded configuration, was able to pass through the pores. The loss of carbonic anhydrase through the membrane was controlled by the dialysis conditions. Dialysis against 0.05 M Tris-HCl for 30 min reduced the denaturant around the protein to a concentration that allowed the return of secondary structure, increasing the hydrodynamic radius, thus preventing protein transmission. Under these conditions a maximum of 42% of carbonic anhydrase was recovered (from a starting concentration of 5 mg/mL) with 94% activity. This is an improvement over refolding carbonic anhydrase by simple batch dilution, which gave a maximum reactivation of 85% with 35% soluble protein yield. The batch refolding of carbonic anhydrase is very sensitive to temperature; however, during HF refolding between 0 and 25°C the temperature sensitivity was considerably reduced. In order to reduce the convection forces that give rise to aggregation and promote refolding the dialyzate was slowly heated from 4 to 25°C. This slow, temperature-controlled refolding gave an improved soluble protein recovery of 55% with a reactivation yield of 90%. The effect of a number of additives on the refolding system performance were tested: the presence of PEG improved both the protein recovery and the recovered activity from the membrane, while the detergents Tween 20 and IGEPAL CA-630 increased only the refolding yield. ©1998 John Wiley & Sons, Inc. Biotechnol Bioeng 57: 590-599, 1998.
    Additional Material: 8 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 119-120 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: No abstract.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 658-662 
    ISSN: 0006-3592
    Keywords: T4 lysozyme ; silica nanoparticles ; synthetic enzyme variants ; surface-induced conformational change ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Maintaining a specific molecular conformation is essential for the proper functioning of an enzyme. A substantial loss of catalytic activity can occur from the displacement caused by even a single amino acid substitution. Activity may also be lost as an enzyme undergoes a conformational change during adsorption. In this study, we investigated the effect of thermostability on the activities of three T4 lysozyme variants after adsorption to 9 nm colloidal silica particles. Less-stable T4 lysozyme variants lost more activity after adsorption than did more stable variants, apparently because they experienced more extensive structural alteration. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 58: 658-662, 1998.
    Additional Material: 4 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 139-148 
    ISSN: 0006-3592
    Keywords: metabolic engineering ; pathway analysis ; metabolic and energetic model ; physiological state ; Saccharomyces cerevisiae ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In this work, an integrated modeling approach based on a metabolic signal flow diagram and cellular energetics was used to model the metabolic pathway analysis for the cultivation of yeast on glucose. This approach enables us to make a clear analysis of the flow direction of the carbon fluxes in the metabolic pathways as well as of the degree of activation of a particular pathway for the synthesis of biomaterials for cell growth. The analyses demonstrate that the main metabolic pathways of Saccharomyces cerevisiae change significantly during batch culture. Carbon flow direction is toward glycolysis to satisfy the increase of requirement for precursors and energy. The enzymatic activation of TCA cycle seems to always be at normal level, which may result in the overflow of ethanol due to its limited capacity. The advantage of this approach is that it adopts both virtues of the metabolic signal flow diagram and the simple network analysis method, focusing on the investigation of the flow directions of carbon fluxes and the degree of activation of a particular pathway or reaction loop. All of the variables used in the model equations were determined on-line; the information obtained from the calculated metabolic coefficients may result in a better understanding of cell physiology and help to evaluate the state of the cell culture process. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 58:139-148, 1998.
    Additional Material: 9 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 149-153 
    ISSN: 0006-3592
    Keywords: Metabolic Control Analysis ; flux control coefficients ; top down MCA ; metabolic engineering ; Corynebacterium glutamicum ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Grouping of reactions around key metabolite branch points can facilitate the study of metabolic control of complex metabolic networks. This top-down Metabolic Control Analysis is exemplified through the introduction of group (flux, as well as concentration) control coefficients whose magnitudes provide a measure of the relative impact of each reaction group on the overall network flux, as well as on the overall network stability, following enzymatic amplification. In this article, we demonstrate the application of previously developed theory to the determination of group flux control coefficients. Experimental data for the changes in metabolic fluxes obtained in response to the introduction of six different environmental perturbations are used to determine the group flux control coefficients for three reaction groups formed around the phosphoenolpyruvate/pyruvate branch point. The consistency of the obtained group flux control coefficient estimates is systematically analyzed to ensure that all necessary conditions are satisfied. The magnitudes of the determined control coefficients suggest that the control of lysine production flux in Corynebacterium glutamicum cells at a growth base state resides within the lysine biosynthetic pathway that begins with the PEP/PYR carboxylation anaplorotic pathway. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 58:149-153, 1998.
    Additional Material: 3 Ill.
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 154-161 
    ISSN: 0006-3592
    Keywords: central carbon pathways ; metabolic optimization ; ethanol production ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Many attempts to engineer cellular metabolism have failed due to the complexity of cellular functions. Mathematical and computational methods are needed that can organize the available experimental information, and provide insight and guidance for successful metabolic engineering. Two such methods are reviewed here. Both methods employ a (log)linear kinetic model of metabolism that is constructed based on enzyme kinetics characteristics. The first method allows the description of the dynamic responses of metabolic systems subject to spatiotemporal variations in their parameters. The second method considers the product-oriented, constrained optimization of metabolic reaction networks using mixed-integer linear programming methods. The optimization framework is used in order to identify the combinations of the metabolic characteristics of the glycolytic enzymes from yeast and bacteria that will maximize ethanol production. The methods are also applied to the design of microbial ethanol production metabolism. The results of the calculations are in qualitative agreement with experimental data presented here. Experiments and calculations suggest that, in resting Escherichia coli cells, ethanol production and glucose uptake rates can be increased by 30% and 20%, respectively, by overexpression of a deregulated pyruvate kinase, while increase in phosphofructokinase expression levels has no effect on ethanol production and glucose uptake rates. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 58:154-161, 1998.
    Additional Material: 7 Ill.
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