Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Great advances have been made in the past decade in the field of NMR spectroscopy. Apart from the development of completely new areas of application, such as in solid-state chemistry, in materials science, in physiological chemistry, and in medicine, with the introduction of new pulse spectroscopic methods and the application of high magnetic field strengths important progress has also been made in the traditional field of high-resolution NMR spectroscopy. Thus, among other things, the observation of metal resonances has been facilitated and new areas of application have been opened up in inorganic and organometallic chemistry. In this review, recent detection methods for spin-1/2 and quadrupolar metal nuclei are presented and discussed. The use of metal-NMR spectroscopy with respect to problems of a typical chemical nature, mainly from the field of organometallics, is demonstrated for a number of selected metal nuclei (25Mg, 27Al, 49Ti, 57Fe, 59Co, 61Ni, 91Zr, 103Rh, and 195Pt). Relations found empirically between chemical shifts and coordination number, oxidation number, and electronic configuration of a metal bound in a complex are emphasized. Furthermore, cases in which the chemical shifts of metal nuclei can be interpreted in terms of the energy difference of frontier orbitals are presented. This aspect leads to the establishment of a relationship between chemical reactivity and NMR parameters for a series of related compounds.
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