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  • Springer Nature  (2.755)
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  • 1
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-04-03
    Beschreibung: This open access book deconstructs the core features of online misinformation and disinformation. It finds that the optimisation of emotions for commercial and political gain is a primary cause of false information online. The chapters distil societal harms, evaluate solutions, and consider what must be done to strengthen societies as new biometric forms of emotion profiling emerge. Based on a rich, empirical, and interdisciplinary literature that examines multiple countries, the book will be of interest to scholars and students of Communications, Journalism, Politics, Sociology, Science and Technology Studies, and Information Science, as well as global and local policymakers and ordinary citizens interested in how to prevent the spread of false information worldwide, both now and in the future.
    Schlagwort(e): media ecology ; emotional AI ; disinformation ; politics of emotion ; economies of emotion ; digital activism ; fake news ; political communication ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence
    Sprache: Englisch
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  • 2
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 3
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    Springer Nature
    Publikationsdatum: 2023-12-20
    Beschreibung: This book presents the most current research results and knowledge from five multidisciplinary themes: Vulnerability of Arctic Environments, Vulnerability of Arctic Societies, Local and Traditional Knowledge, Building Long-term Human Capacity, New Markets for the Arctic, including tourism and safety. The themes are those discussed at the first ever UArctic Congress Science Section, St. Petersburg, Russia, September 2016. The book looks at the Arctic from a holistic perspective; how the environment (both marine and terrestrial) and communities can adapt and manage the changes due to climate change. The chapters provide examples of the state-of-the-art research, bringing together both scientific and local knowledge to form a comprehensive and cohesive volume.
    Schlagwort(e): GE1-350 ; environment ; tourism ; vulnerability ; Arctic ; indigenous knowledge ; marine and terrestrial polar landscapes ; climate change ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
    Sprache: Englisch
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  • 4
    Publikationsdatum: 2024-04-05
    Beschreibung: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Schlagwort(e): QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Sprache: Englisch
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  • 5
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-08
    Beschreibung: This open access book makes a case for extending logic beyond its traditional boundaries, to encompass not only statements but also also questions. The motivations for this extension are examined in detail. It is shown that important notions, including logical answerhood and dependency, emerge as facets of the fundamental notion of entailment once logic is extended to questions, and can therefore be treated with the logician’s toolkit, including model-theoretic constructions and proof systems. After motivating the enterprise, the book describes how classical propositional and predicate logic can be made inquisitive—i.e., extended conservatively with questions—and what the resulting logics look like in terms of meta-theoretic properties and proof systems. Finally, the book discusses the tight connections between inquisitive logic and dependence logic.
    Schlagwort(e): Logic of Questions ; Inquisitive Logic ; Information Semantics ; Logic of Dependency ; Dependence Logic ; Intuitionistic Logic ; Proofs-as-Programs ; Information Types ; role of questions in logic ; Questions in propositional logic ; reasoning with questions ; Questions in first-order logic ; Questions in modal logic ; Connections with intuitionistic logic ; Connections with dependence logic ; how classical logic can be made inquisitive ; connection inquisitive, intuitionistic, dependence logic ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTL Philosophy: logic ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTL Philosophy: logic ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations
    Sprache: Englisch
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  • 6
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    Springer Nature
    Publikationsdatum: 2022-01-31
    Beschreibung: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
    Schlagwort(e): RC648-665 ; RC620-627 ; human brown adipose tissue plasticity ; type 2 diabetes ; Tryptophan-kynurenine metabolites ; metabolic diseases ; muscle glycogen ; AMPK ; skeletal muscle microRNAs ; FNDC5/irisin ; obesity
    Sprache: Englisch
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  • 7
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    Springer Nature | Springer
    Publikationsdatum: 2022-06-21
    Beschreibung: This open access book is about socio-spatial theory in, and the nature of, Nordic geography. From both historical and contemporary perspectives, the book engages with theorisations of geography in the Nordic countries. Including chapters by geographers from Denmark, Finland, Iceland, Norway and Sweden, it reflects how theories about the relations between the social and the spatial have been developed, adopted and critiqued in Nordic human geography in relation to a wide range of themes, concepts and approaches. The book also traces institutional developments, distinct geographical traditions and intellectual histories, as well as authors’ own experiences as geographers in and beyond the Nordic area. The chapters together introduce and engage with debates and discussions that permeate Nordic geography and allows readers a glimpse of geographical thinking and the role of socio-spatial theory in the Nordic countries. By providing insights into how geographical ideas emerge, travel and are translated and adapted in specific contexts, the book contributes to debates about historical-geographical situatedness and theorisations of geography.
    Schlagwort(e): History of Nordic geography ; Socio-spatial theory in Nordic Geography ; Debates within Nordic geography ; History of geographical thought ; Theoretical geographical perspectives and approaches ; Radical and Critical Geography ; History of university developments in the Nordic countries ; Auto-biographical reflections among Nordic geographers ; Nordic small state geopolitics ; Nordic racial exceptionalism ; Regional planning ; Geography and landscape ; Marxist theorisation of geography ; Mobility and rural-urban transformations ; Nordic gender geography ; Urban space ; Nordic social and cultural geography ; Politicisizing nature in Nordic geography ; Tourism studies in Nordic geography ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBA Social theory ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography
    Sprache: Englisch
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  • 8
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 9
    Publikationsdatum: 2024-04-11
    Beschreibung: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Schlagwort(e): TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 10
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    Springer Nature | Springer Nature Switzerland
    Publikationsdatum: 2024-04-05
    Beschreibung: In recent years, there has been an increased interest in exploring the connections between various disciplines of mathematics and theoretical physics such as representation theory, algebraic geometry, quantum field theory, and string theory. One of the challenges of modern mathematical physics is to understand rigorously the idea of quantization. The program of quantization by branes, which comes from string theory, is explored in the book. This open access book provides a detailed description of the geometric approach to the representation theory of the double affine Hecke algebra (DAHA) of rank one. Spherical DAHA is known to arise from the deformation quantization of the moduli space of SL(2,C) flat connections on the punctured torus. The authors demonstrate the study of the topological A-model on this moduli space and establish a correspondence between Lagrangian branes of the A-model and DAHA modules. The finite-dimensional DAHA representations are shown to be in one-to-one correspondence with the compact Lagrangian branes. Along the way, the authors discover new finite-dimensional indecomposable representations. They proceed to embed the A-model story in an M-theory brane construction, closely related to the one used in the 3d/3d correspondence; as a result, modular tensor categories behind particular finite-dimensional representations with PSL(2,Z) action are identified. The relationship of Coulomb branch geometry and algebras of line operators in 4d N = 2* theories to the double affine Hecke algebra is studied further by using a further connection to the fivebrane system for the class S construction. The book is targeted at experts in mathematical physics, representation theory, algebraic geometry, and string theory. This is an open access book.
    Schlagwort(e): Geometric representation theory ; Double affine Hecke algebra ; Topological quantum field theory ; Modular tensor category ; Symmetric functions ; Coulomb branch ; Fukaya category ; thema EDItEUR::P Mathematics and Science::PH Physics::PHU Mathematical physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBM Geometry::PBMW Algebraic geometry ; thema EDItEUR::P Mathematics and Science::PH Physics::PHQ Quantum physics (quantum mechanics and quantum field theory)
    Sprache: Englisch
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  • 11
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 12
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    Frontiers Media SA
    Publikationsdatum: 2023-12-21
    Beschreibung: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Schlagwort(e): R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 13
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    Springer Nature | Springer Singapore
    Publikationsdatum: 2022-03-16
    Beschreibung: This book is open access under a CC BY-NC-ND 4.0 license. Multinational corporations (MNCs) have long played a crucial role in the Chinese economy. This role is one that is set to continue in the post-pandemic era as China works to transit to a high-quality growth model that is more sustainable and innovation-driven. With global experience and front-line involvement in some of the most pressing economic, technological, and environmental issues of our day, leading figures in MNCs and chambers of commerce are well placed to share insights that could potentially contribute to policymaking and development strategies so that everyone can “make the most” of China’s future. This collection of essay aims to share these invaluable insights with a wider audience, offering balanced and diverse perspectives from companies and advocacy groups working on a range of issues related to China’s domestic development, international economic cooperation, and China-US competition. These insights are useful not only for the wider business community, but also for academics, policymakers, students, and anyone trying to deepen their understanding of this exciting period of “transition and opportunity,” and make the most of China’s bright future.
    Schlagwort(e): China Business Opportunity ; Multinationals Firms/MNCs in China ; Foreign Business in China ; CEO in China ; Chamber of Commerce in China ; International Business Leaders ; Economic Transformation ; Transition and Industry Opportunity ; Business Environment in China ; Global Business Strategy ; Open Access ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJK International business ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJS Sales & marketing::KJSM Market research
    Sprache: Englisch
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  • 14
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Schlagwort(e): RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 15
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Schlagwort(e): Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Sprache: Englisch
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  • 16
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    Frontiers Media SA
    Publikationsdatum: 2023-12-21
    Beschreibung: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Schlagwort(e): R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 17
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Schlagwort(e): RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 18
    Publikationsdatum: 2023-12-21
    Beschreibung: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Schlagwort(e): R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 19
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2022-07-14
    Beschreibung: This open access book describes strategies and experiences of highly skilled professionals in improving oncology care worldwide. The book is structured into three main sections with several chapters each, reflecting the authors' individual, real-life experiences. It explores ways to improve oncology education and scientific training, how to set up and run a clinical research facility ethically and efficiently in low- and middle-income settings, addressing the challenges that the workforce encounters in the real world. The main challenges of today’s oncologists seem to be the ever-growing patient care and administrative workload and the risk of burn-out. What are the best strategies to maintain a healthy work-life for the benefit of the patients, the physicians and society, taking into account the different needs, depending on factors like peace, social and gender equality? This book addresses oncologists all over the world and their allies throughout the associated industries to highlight the importance of shared and sustainable education, clinical research and global cancer care.
    Schlagwort(e): SDG3 ; Wellbeing ; Public Health ; Sustainable development ; Equal access ; Cancer care ; Medical education ; Clinical research ; Essential medicines ; Online learning ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::M Medicine::MQ Nursing & ancillary services::MQP Pharmacy / dispensing
    Sprache: Englisch
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  • 20
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Schlagwort(e): RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 21
    Publikationsdatum: 2023-12-21
    Beschreibung: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Schlagwort(e): R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 22
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Sprache: Englisch
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  • 23
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-11
    Beschreibung: This open access book will give insights into global issues of work and work systems design from a wide range of perspectives. Topics like the impact of AI in the workplace as well as design for digital sovereignty at the workplace or foresight processes for digital work are covered. Practical cases, empirical results and theoretical considerations are not only taken from Germany and Europe, but also from Southeast Asia, South Africa, Middle America, and Australia. The book intends to expand the so far national view on the aspects of digital work (e.g. like in Ernst Hartmann’s immensely successful work “Zukunft der Arbeit in Industrie 4.0”) into an international context – thus showing not only common challenges, but also offering suggestions, best practice examples or thoughts from different global regions.
    Schlagwort(e): Digital Work ; Digital Sovereignty ; Artificial Intelligence ; Capacity Building ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCD Economics of industrial organization ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence
    Sprache: Englisch
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  • 24
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-04-08
    Beschreibung: This edited collection explores the agency of women who do violence and have violence done to them. Topics covered include rape, pornography, prostitution, suicide bombing and domestic violence. The volume contributes to the philosophical and theoretical debate, as well as offering practical, social and political responses to the issues examined.
    Schlagwort(e): violence ; prostitution ; suicide bombing ; women ; rape ; pornography ; domestic violence ; bic Book Industry Communication::H Humanities::HP Philosophy::HPQ Ethics & moral philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFK Feminism & feminist theory ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKV Crime & criminology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls::JBSF11 Feminism and feminist theory ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology
    Sprache: Englisch
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  • 25
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Sprache: Englisch
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  • 26
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
    Sprache: Englisch
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  • 27
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    Frontiers Media SA
    Publikationsdatum: 2023-12-21
    Beschreibung: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Schlagwort(e): R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 28
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    Frontiers Media SA
    Publikationsdatum: 2024-03-29
    Beschreibung: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Schlagwort(e): BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Sprache: Englisch
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  • 29
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-03-29
    Beschreibung: This open access book makes a contribution to our understanding of one of the social challenges facing many western nations i.e. the challenge of an ageing population. It specifically addresses the issue of competence among older employees. Others have studied ageing populations in terms of the economic burden or the pressure on healthcare services and generally view the rising numbers of seniors more as a challenge than an opportunity. In this book, authors discuss ways of gaining positive benefits from our ageing and more experienced work force.
    Schlagwort(e): older employees ; active ageing ; lifelong learning ; competence ; ageing workers ; late careers ; Open Access ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBK Sociology: family and relationships
    Sprache: Englisch
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  • 30
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2022-07-14
    Beschreibung: This book is about making weather warnings more effective in saving lives, property, infrastructure and livelihoods, but the underlying theme of the book is partnership. The book represents the warning process as a pathway linking observations to weather forecasts to hazard forecasts to socio-economic impact forecasts to warning messages to the protective decision, via a set of five bridges that cross the divides between the relevant organisations and areas of expertise. Each bridge represents the communication, translation and interpretation of information as it passes from one area of expertise to another and ultimately to the decision maker, who may be a professional or a member of the public. The authors explore the partnerships upon which each bridge is built, assess the expertise and skills that each partner brings and the challenges of communication between them, and discuss the structures and methods of working that build effective partnerships. The book is ordered according to the “first mile” paradigm in which the decision maker comes first, and then the production chain through the warning and forecast to the observations is considered second. This approach emphasizes the importance of co-design and co-production throughout the warning process. The book is targeted at professionals and trainee professionals with a role in the warning chain, i.e. in weather services, emergency management agencies, disaster risk reduction agencies, risk management sections of infrastructure agencies. This is an open access book.
    Schlagwort(e): Weather warnings ; Hazard forecasts ; Science partnerships ; Risk perception ; Warning providers ; Disaster risk management ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences::RBP Meteorology & climatology ; bic Book Industry Communication::P Mathematics & science
    Sprache: Englisch
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  • 31
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-03-26
    Beschreibung: This open access book challenges the contemporary relevance of the current model of knowledge production. It argues that the full digitisation of society sharply accelerated by the COVID-19 pandemic has added extreme complexity to the world, conclusively exposing the inadequacy of our current model of knowledge creation. Addressing many of the different ways in which reality has been transformed by technology – the pervasive adoption of big data, the fetishisation of algorithms and automation, and the digitalisation of education and research – Viola examines how the rigid conceptualisation in disciplines’ division and competition is complicit of promoting a narrative which has paired computational methods with exactness and neutrality whilst stigmatising consciousness and criticality as carriers of biases and inequality. Taking the humanities as a focal point, the author retraces schisms in the field between the humanities, the digital humanities and critical digital humanities; these are embedded, she argues, within old dichotomies: sciences vs humanities, digital vs non-digital and authentic vs non-authentic. Through the analysis of personal use cases and exploring a variety of applied contexts such as digital heritage practices, digital linguistic injustice, critical digital literacy and critical digital visualisation, the book shows a third way: knowledge creation in the digital.
    Schlagwort(e): Digital Hermeneutics ; digital history ; data humanities ; digital turn ; computational methods ; metadata ; information technology ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies
    Sprache: Englisch
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  • 32
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2021-02-10
    Beschreibung: This third and last open access volume in the series takes the perspective of non-EU countries on immigrant social protection. By focusing on 12 of the largest sending countries to the EU, the book tackles the issue of the multiple areas of sending state intervention towards migrant populations. Two “mirroring” chapters are dedicated to each of the 12 non-EU states analysed (Argentina, China, Ecuador, India, Lebanon, Morocco, Russia, Senegal, Serbia, Switzerland, Tunisia, Turkey). One chapter focuses on access to social benefits across five core policy areas (health care, unemployment, old-age pensions, family benefits, guaranteed minimum resources) by discussing the social protection policies that non-EU countries offer to national residents, non-national residents, and non-resident nationals. The second chapter examines the role of key actors (consulates, diaspora institutions and home country ministries and agencies) through which non-EU sending countries respond to the needs of nationals abroad. The volume additionally includes two chapters focusing on the peculiar case of the United Kingdom after the Brexit referendum. Overall, this volume contributes to ongoing debates on migration and the welfare state in Europe by showing how non-EU sending states continue to play a role in third country nationals’ ability to deal with social risks. As such this book is a valuable read to researchers, policy makers, government employees and NGO’s.
    Schlagwort(e): Social Sciences, general ; Microeconomics ; Social Policy ; Sociology of Migration ; Open access ; Non-EU countries ; Immigrant social protection ; Migrant populations ; Argentina, China, Ecuador, India ; Lebanon, Morocco, Russia ; Senegal, Serbia, Switzerland ; Tunisia, Turkey ; Health care ; Unemployment ; Old-age pensions ; Guaranteed minimum resources ; Family benefits ; Migration and integration ; Sending states ; Society & Social Sciences ; Sociology ; Political economy ; Social & ethical issues ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCC Microeconomics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy
    Sprache: Englisch
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  • 33
    Publikationsdatum: 2024-04-14
    Beschreibung: Computer science
    Schlagwort(e): Computer science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Sprache: Englisch
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  • 34
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    Frontiers Media SA
    Publikationsdatum: 2024-03-31
    Beschreibung: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Schlagwort(e): QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Sprache: Englisch
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  • 35
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 36
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-03-23
    Beschreibung: This open access book examines how Pinewood came to be Britain’s dominant film studio complex, focusing on key years following the Second World War. It presents a revisionist, micro history of the studio and its longevity during a particularly turbulentperiod, explaining Pinewood’s survival at a time when other major film studios such as Denham closed. This book also provides contemporary insights into how Pinewood’s technologies, practices, and filmmaking methods compared to Hollywood’s. Thirteen films produced in1946–47 are analysed in detail, tracking how economic pressures engendered many creative techniques and innovative technologies. Prevailing cultures of management and labour organization are foregrounded, as well as insights into being a studio employee. These are vividly brought to life through an in-depthfocus on the in-house studio magazine Pinewood Merry-Go-Round, which provides rare details of sports and leisure activities organized at the studios.
    Schlagwort(e): Pinewood ; Film history ; British cinema ; Film studios ; Innovation ; Technology ; Leisure cultures ; Labour history ; Set design ; thema EDItEUR::A The Arts::AT Performing arts::ATF Films, cinema ; thema EDItEUR::A The Arts::AT Performing arts::ATJ Television ; thema EDItEUR::A The Arts::AT Performing arts::ATF Films, cinema::ATFX Filmmaking and production: technical and background skills
    Sprache: Englisch
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  • 37
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    Springer Nature | Springer Nature Switzerland
    Publikationsdatum: 2024-04-14
    Beschreibung: This open access book constitutes revised selected papers from the International Workshops held at the 4th International Conference on Process Mining, ICPM 2022, which took place in Bozen-Bolzano, Italy, during October 23–28, 2022. The conference focuses on the area of process mining research and practice, including theory, algorithmic challenges, and applications. The co-located workshops provided a forum for novel research ideas. The 42 papers included in this volume were carefully reviewed and selected from 89 submissions. They stem from the following workshops: – 3rd International Workshop on Event Data and Behavioral Analytics (EDBA) – 3rd International Workshop on Leveraging Machine Learning in Process Mining (ML4PM) – 3rd International Workshop on Responsible Process Mining (RPM) (previously known as Trust, Privacy and Security Aspects in Process Analytics) – 5th International Workshop on Process-Oriented Data Science for Healthcare (PODS4H) – 3rd International Workshop on Streaming Analytics for Process Mining (SA4PM) – 7th International Workshop on Process Querying, Manipulation, and Intelligence (PQMI) – 1st International Workshop on Education meets Process Mining (EduPM) – 1st International Workshop on Data Quality and Transformation in Process Mining (DQT-PM)
    Schlagwort(e): process mining ; process discovery ; process analytics ; process querying ; conformance checking ; predictive process monitoring ; data science ; knowledge graphs ; event data ; streaming analytics ; machine learning ; deep learning ; business process management ; health informatics ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNF Data mining ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJQ Business mathematics and systems ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQM Machine learning ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics::UBH Digital and information technologies: Health and safety aspects
    Sprache: Englisch
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  • 38
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2022-03-16
    Beschreibung: This book discusses and analyses global policies and practices aimed at promoting equity in higher education participation and attainment. Although the massification of higher education systems has facilitated the participation of students from deprived backgrounds, socioeconomic inequalities persist in access to the most prestigious institutions and programmes. Privileged students benefit from a number of advantages in the competition for selective and scarce places: access to information, lower aversion to debt, higher expectations, better previous schooling and higher academic achievement. The chapters present a critical analysis of equity policies in different countries – with or without affirmative action policies, within a context of neoliberal policies or within a social democratic model – and the reasons why they have failed to promote equity and fairness, preventing students from achieving their full educational potential. This is an open access book.
    Schlagwort(e): equity in higher education ; access to higher education ; participation in higher education ; attainment and retention ; higher education policy ; Open Access ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Sprache: Englisch
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  • 39
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-03-30
    Beschreibung: This open access book explores the idea that corporate rhetoric can be a force for good. In developing a new framework for analysis and discussion of green marketing, the authors argue that corporate environmental rhetoric can be harnessed to contribute to climate transition and a more sustainable market economy. The work explores the transformative power inherent in green promises and sets a vision of what green marketers should strive for. Engaging with selected research on organizational theory, the authors negotiate the conflicting paradigms of rhetorical theory and their relation to the study of corporate legitimation practices. The resulting theoretical framework provides an analytical scheme that can be useful in various disciplines – such as sociology, economics, law, marketing theory, and communication. It also illustrates how we can find new answers to contemporary challenges by re-imagining rhetoric. This is an open access book.
    Schlagwort(e): climate rhetoric ; Sustainability ; Greenwashing ; qualitative analysis of communication ; rhetorical studies ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJS Sales and marketing::KJSP Public relations ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJS Sales and marketing ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Sprache: Englisch
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  • 40
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-01-16
    Beschreibung: This open access book provides multidisciplinary perspectives on the potential of agroforestry to mitigate the negative impacts of climate change on cocoa production. Against the backdrop of increasingly precarious farmer livelihoods, it focuses on cocoa-agroforestry in Ghana – the second largest producer of cocoa in the world. Taking the reader on a journey across experimental plots and on-farm studies, the book delivers a holistic understanding of cocoa-agroforestry. Chapters examine historical yield and climate interactions, the effects of heat and drought on cocoa plants and the role of differing shade trees on soil fertility, yields, pests and diseases. The book discusses the socioeconomics of shade tree management, including cost-benefits, tree rights and competition for natural resources emphasizing policy implications and recommendations. Taking a multidisciplinary approach to climate-agriculture interactions, the book provides an innovative understanding of agroforestry and perennial cropping systems that goes beyond the Ghanaian cocoa belt. It is of relevance to students, researchers, farmers, practitioners and policymakers working with agroforestry and climate change adaptation. This is an open access book.
    Schlagwort(e): cocoa ; climate change ; multidisciplinary ; mitigation ; adaptation ; resilience ; climate-smart agriculture ; Ghana ; shade trees ; farming systems ; ecophysiology ; land rights ; tree use rights ; smallholder farming ; rural livelihoods ; technical efficiency ; perennial crop ; profitability ; sustainability ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNF Environmental management ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNU Sustainability
    Sprache: Englisch
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  • 41
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    Springer Nature
    Publikationsdatum: 2024-03-23
    Beschreibung: This book explores the interrelation between diversity in migrants’ internal relations and their experience of inequality in local and global contexts. Taking the case of Hamburg-based Iranians, it traces evaluation processes in ties between professionals – artists and entrepreneurs – since the 1930s, examining migrants’ potential to act upon hierarchical structures. Building on long-term ethnographic fieldwork and archival work, the book centers on differentiation, combining a diversity study with a focus on locality, with a transnational migration study, analysing strategies of capital creation and anthropological value theory. The analysis of migrants’ agency tackles questions of independence and cooperation in kinship, associations, transnational entrepreneurship and cultural events within the context of the position of Germany and Iran in the global politico-economic landscape. This material will be of interest to scholars and students of anthropology, sociology, migration, urbanism and Iranian studies, as well as Iranian-Germans and those interested in the entanglement of global and local power relations.
    Schlagwort(e): Social sciences ; Emigration and immigration ; Emigration and immigration ; Ethnography ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFH Migration, immigration and emigration ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PB Relating to peoples: ethnic groups, indigenous peoples, cultures and other groupings of people::5PBC Relating to migrant groups / diaspora communities or peoples ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Sprache: Englisch
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  • 42
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    Springer Nature | Springer
    Publikationsdatum: 2024-04-08
    Beschreibung: This book is open access under a CC BY 4.0 license. This book addresses the age-old problem of infinite regresses in epistemology. How can we ever come to know something if knowing requires having good reasons, and reasons can only be good if they are backed by good reasons in turn? The problem has puzzled philosophers ever since antiquity, giving rise to what is often called Agrippa's Trilemma. The current volume approaches the old problem in a provocative and thoroughly contemporary way. Taking seriously the idea that good reasons are typically probabilistic in character, it develops and defends a new solution that challenges venerable philosophical intuitions and explains why they were mistakenly held. Key to the new solution is the phenomenon of fading foundations, according to which distant reasons are less important than those that are nearby. The phenomenon takes the sting out of Agrippa's Trilemma; moreover, since the theory that describes it is general and abstract, it is readily applicable outside epistemology, notably to debates on infinite regresses in metaphysics. The book is a potential game-changer and a must for any advanced student or researcher in the field.
    Schlagwort(e): Epistemology ; Mathematical Logic and Foundations ; Statistical Theory and Methods ; History and Philosophical Foundations of Physics ; Operations Research/Decision Theory ; Philosophical Foundations of Physics and Astronomy ; Operations Research and Decision Theory ; Epistemic Justification ; Infinite Regress ; Regresses in Epistemology ; Regresses in Ethics ; Regresses in Metaphysics ; Regresses in Philosophy of Mind ; Open Access ; Philosophy: epistemology & theory of knowledge ; Mathematical foundations ; Mathematical logic ; Probability & statistics ; History of science ; Operational research ; Management decision making ; bic Book Industry Communication::H Humanities::HP Philosophy::HPK Philosophy: epistemology & theory of knowledge ; bic Book Industry Communication::P Mathematics & science::PB Mathematics::PBC Mathematical foundations ; bic Book Industry Communication::P Mathematics & science::PB Mathematics::PBT Probability & statistics ; bic Book Industry Communication::P Mathematics & science::PD Science: general issues::PDX History of science ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJT Operational research ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTK Philosophy: epistemology and theory of knowledge ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJT Operational research
    Sprache: Englisch
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  • 43
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    Frontiers Media SA
    Publikationsdatum: 2022-01-31
    Beschreibung: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Schlagwort(e): RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Sprache: Englisch
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  • 44
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Schlagwort(e): RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 45
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 46
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
    Sprache: Englisch
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  • 47
    Publikationsdatum: 2023-12-21
    Beschreibung: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Schlagwort(e): R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 48
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Sprache: Englisch
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  • 49
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-14
    Beschreibung: This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension. The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.
    Schlagwort(e): open access ; Statistical learning ; Bayesian regression ; Deep learning ; Non linear regression ; Plant breeding ; Crop management ; multi-trait multi-environments models ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TV Agriculture and farming::TVB Agricultural science ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics
    Sprache: Englisch
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  • 50
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    Springer Nature | Springer
    Publikationsdatum: 2024-04-05
    Beschreibung: This open access textbook aims at providing detailed explanations on how to design and construct image analysis workflows to successfully conduct bioimage analysis. Addressing the main challenges in image data analysis, where acquisition by powerful imaging devices results in very large amounts of collected image data, the book discusses techniques relying on batch and GPU programming, as well as on powerful deep learning-based algorithms. In addition, downstream data processing techniques are introduced, such as Python libraries for data organization, plotting, and visualizations. Finally, by studying the way individual unique ideas are implemented in the workflows, readers are carefully guided through how the parameters driving biological systems are revealed by analyzing image data. These studies include segmentation of plant tissue epidermis, analysis of the spatial pattern of the eye development in fruit flies, and the analysis of collective cell migration dynamics. The presented content extends the Bioimage Data Analysis Workflows textbook (Miura, Sladoje, 2020), published in this same series, with new contributions and advanced material, while preserving the well-appreciated pedagogical approach adopted and promoted during the training schools for bioimage analysis organized within NEUBIAS – the Network of European Bioimage Analysts. This textbook is intended for advanced students in various fields of the life sciences and biomedicine, as well as staff scientists and faculty members who conduct regular quantitative analyses of microscopy images.
    Schlagwort(e): Analyzing Image Data in Biology ; Building a Bioimage Analysis Workflow ; Computational Analysis ; Chosing the Correct Components for Given Biological Questions ; Data Handling and Plotting ; Deep Learning ; Fast Computation ; GPU-Acceleration ; Handling Biological data ; Machine Learning ; Phyton ; Processing Language ; Understanding Bioimage Analysis Software ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 51
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
    Sprache: Englisch
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  • 52
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    Springer Nature | Springer Nature Singapore
    Publikationsdatum: 2024-04-04
    Beschreibung: This open access book explores the past and present of Quanzhou (Zayton) and the rich diversity and tolerance that kindled Quanzhou’s innovativeness and helped it prosper both commercially and culturally—values that are today being embraced by China’s global trade partners. Quanzhou (Zayton), Marco Polo’s port of departure and Columbus’ goal in China, was not only the start of the Maritime Silk Road and the Middle Age’s greatest port but also centuries ahead of its time in its tolerance and diversity. The fabled “City of Light” had 7 mosques for its 40,000 Muslims, some of whom served in government, as well as 3 Franciscan cathedrals funded in part by the emperor, Jewish synagogues, and centers for Nestorian Christians, Hindus, Taoists, Manicheans, Jains, etc. As Franciscan Bishop Andrew of Perugia wrote in 1322, “Tis a fact that in this vast empire, there are people of every nation under heaven, and every sect, and all and sundry are allowed to live freely according to their creed.” In 2021, UNESCO designated “Quanzhou, Emporium of the World,” as a world heritage site, and the city is now the hub of the Belt and Road Initiative, the 21st Century Silk Road, which was inspired by ancient Quanzhou.
    Schlagwort(e): Maritime Silk Road ; Admiral Zheng He and Sinbad ; Chinese White Porcelain ; Chinese Marionettes ; Koxinga and Zhengchenggong ; Southern Shaolin Kung Fu ; Belt and Road Initiative ; Islam in China ; Ibn Battuta in China ; Nestorian Christians in China ; China UNESCO World Heritage ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBH Literary studies: c 1900 to c 2000
    Sprache: Englisch
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  • 53
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    Frontiers Media SA
    Publikationsdatum: 2024-03-30
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): biobank ; samples ; data ; biobank network ; BBMRI
    Sprache: Englisch
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  • 54
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Sprache: Englisch
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  • 55
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Sprache: Englisch
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  • 56
    Publikationsdatum: 2024-04-05
    Beschreibung: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Schlagwort(e): RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 57
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    Springer Nature | Apress
    Publikationsdatum: 2024-04-14
    Beschreibung: Create mods using the popular game Farming Simulator with Lua, a versatile scripting language that can run on various platforms and applications. This open access book is best suited for programmers who want to learn how to use Lua to write scripts that can enhance and extend the gameplay experience. You'll start by reviewing the basics of programming in Lua and then move on to advanced topics, such as object-oriented programming, vehicle and placeable specializations, network synchronization, and creating custom user interfaces. With step-by-step instructions and detailed explanations, you'll see how to create scripts that modify game mechanics and add new features to the game. The practical examples and projects are ideal for providing hands-on experience with Lua scripting. Whether you are a creator looking to take your skills to the next level or a game developer interested in learning a new programming language, Scripting Farming Simulator with Lua is the ultimate guide to mastering Lua scripting. What You'll Learn Understand the fundamentals of programming in LUA Implement a basic “Hello-World” mod Add a new graphical user interface to your mod Use hook scripts to extend base game features Publish your mod on the official Farming Simulator ModHub Who This Book Is For Creators who want to add new features to Farming Simulator; game developers who want to learn a new programming language for modding purposes, and anyone who wants to expand their knowledge of programming and scripting.
    Schlagwort(e): Modding ; Lua ; Farming Simulator ; Scripting ; GIANTS Editor ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMK Games development and programming
    Sprache: Englisch
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  • 58
    Publikationsdatum: 2024-04-05
    Beschreibung: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Schlagwort(e): RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 59
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    Springer Nature | Springer
    Publikationsdatum: 2021-02-10
    Beschreibung: This open access book provides anthropological insights into the arduous yet rewarding journeys involved in selected TESOL teachers’ pedagogical transition to teaching English for Academic Purposes (EAP) at universities in Shanghai, the largest metropolitan area in China. Applying a unique combination of ethnography and phenomenology, the book offers innovative new perspectives on teacher education research. Drawing on the latest language education theory, it outlines a practitioner-friendly approach to EAP literacy. Teacher readers will especially benefit from the case studies presented here, which provide role models for teacher change in educational reform, as well as advice on their academic careers. In addition to addressing a timely and important research gap on EAP teachers in non-Western countries, the book is the ideal choice for readers interested in an update on English education in China.
    Schlagwort(e): Philosophy of Education ; Language Education ; Teaching and Teacher Education ; Social Anthropology ; EAP Teacher Education ; EAP Teaching ; University English Teaching ; China Higher Education ; Teacher Change ; Open Access ; Philosophy & theory of education ; Language: reference & general ; Teacher training ; Social & cultural anthropology ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education ; bic Book Industry Communication::C Language::CB Language: reference & general ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMT Teacher training ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography
    Sprache: Englisch
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  • 60
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    Springer Nature | Apress
    Publikationsdatum: 2024-04-14
    Beschreibung: Computer science
    Schlagwort(e): Computer science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Sprache: Englisch
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  • 61
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-14
    Beschreibung: This is an open access book. Statistical machine learning (ML) has triggered a renaissance of artificial intelligence (AI). While the most successful ML models, including Deep Neural Networks (DNN), have developed better predictivity, they have become increasingly complex, at the expense of human interpretability (correlation vs. causality). The field of explainable AI (xAI) has emerged with the goal of creating tools and models that are both predictive and interpretable and understandable for humans. Explainable AI is receiving huge interest in the machine learning and AI research communities, across academia, industry, and government, and there is now an excellent opportunity to push towards successful explainable AI applications. This volume will help the research community to accelerate this process, to promote a more systematic use of explainable AI to improve models in diverse applications, and ultimately to better understand how current explainable AI methods need to be improved and what kind of theory of explainable AI is needed. After overviews of current methods and challenges, the editors include chapters that describe new developments in explainable AI. The contributions are from leading researchers in the field, drawn from both academia and industry, and many of the chapters take a clear interdisciplinary approach to problem-solving. The concepts discussed include explainability, causability, and AI interfaces with humans, and the applications include image processing, natural language, law, fairness, and climate science.
    Schlagwort(e): Computer Science ; Informatics ; Conference Proceedings ; Research ; Applications ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQM Machine learning
    Sprache: Englisch
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  • 62
    Publikationsdatum: 2024-04-05
    Beschreibung: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Schlagwort(e): RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 63
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    Springer Nature | Springer Nature Singapore
    Publikationsdatum: 2024-04-06
    Beschreibung: This open access book is the first of a two-volume series focusing on how people are being enabled or constrained to live well in today’s world, and how to bring into reality a world worth living in for all. The chapters offer unique narratives drawing on the perspectives of diverse groups such as: asylum-seeking and refugee youth in Australia, Finland, Norway and Scotland; young climate activists in Finland; Australian Aboriginal students, parents and community members; families of children who tube feed in Australia; and international research students in Sweden. The chapters reveal not just that different groups have different ideas about a world worth living in, but also show that, through their collaborative research initiative, the authors and their research participants were bringing worlds like these into being. The volume extends an invitation to readers and researchers in education and the social sciences to consider ways to foster education that realises transformed selves and transformed worlds: the good for each person, the good for humankind, and the good for the community of life on the planet. The book also includes theoretical chapters providing the background and rationale behind the notion of education as initiating people into ‘living well in a world worth living in'. An introductory chapter discusses the origins of the concept and the phrase.
    Schlagwort(e): Living well in a world worth living in ; Theory of practice architectures ; Cultural-discursive arrangements ; Material-economic arrangements ; Social-political arrangements ; Sayings, doings and relatings ; double purpose of education ; PEP International ; Pedagogy, education, and praxis ; Educational Praxis in Australia, Finland.. ; Global practices of social justice ; Global practices of sustainability ; Global practices of wellbeing ; Global practices of praxis ; Eco-social recognition through education ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::J Society and Social Sciences::JN Education::JNA Philosophy and theory of education
    Sprache: Englisch
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  • 64
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    Unbekannt
    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Sprache: Englisch
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  • 65
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-11
    Beschreibung: This open access book shows some of the highlights presented at the XV Ibero-American Congress of Mechanical Engineering. The papers explore the forefront of Mechanical Engineering, containing research into fluid mechanics, energy systems, tribology, materials science, robotics, mechatronics, biomechanics, instrumentation, thermodynamics, and mechanical sustainability.
    Schlagwort(e): Thermal engineering ; Manufacturing processes ; Numerical methods ; Robotics ; Metallurgy ; Fluid mechanics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGB Mechanical engineering
    Sprache: Englisch
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  • 66
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    Springer Nature | Springer Nature Singapore
    Publikationsdatum: 2024-04-11
    Beschreibung: This open access book introduces the magnesium resources in the world and the layout of this industry, the harmless handling/recycling of magnesium slag, and the process of magnesium silicothermic reduction (Pidgeon process) to produce the slag. Examples and experimental data in this book are from the author group’s research programs, as well as the recent researches in China. The book could provide precious reference to scientists and engineers in the field of recycling and environment friendly use of the industrial solid wastes. It could also be used for researchers and students who are interested in relevant field.
    Schlagwort(e): Magnesium Slag ; Harmless Treatment ; Solid Waste ; Comprehensive Utilization ; Pollution Control ; Magnesium Silicothermic Reduction ; Pidgeon Process ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNH Waste management ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment
    Sprache: Englisch
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  • 67
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    Unbekannt
    Springer Nature | Springer
    Publikationsdatum: 2024-04-04
    Beschreibung: This open access book introduces the modern tontine and its applications in retirement and decumulation. Personal financial management in the later stages of life presents unique challenges, and renowned retirement planning expert Dr. Milevsky proposes the modern tontine as a solution. With the goal of guiding professionals and retirees in more efficient decumulation, the book demonstrates how to build a modern tontine. It is technically oriented, employing a cookbook format, featuring R code, and examining retirement planning through a statistical lens. This how-to guide, which is a sequel to his 2020 book “Retirement Income Recipes in R”, will be invaluable for retirement planning professionals and advisors, as well as for PhD scholars in retirement planning, quantitative finance, and related fields. This book is open access.
    Schlagwort(e): tontine ; risk management ; retirement ; decumulation ; insurance ; Business Analytics ; Mathematical Finance ; Statistical Finance ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics
    Sprache: Englisch
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  • 68
    facet.materialart.
    Unbekannt
    Springer Nature | Springer Nature Singapore
    Publikationsdatum: 2024-04-11
    Beschreibung: This open-access book aims to highlight the coming surge of 5G network-based applications and predicts that the centralized networks and their current capacity will be incapable of meeting the demands. The book emphasizes the benefits and challenges associated with the integration of 5G networks with varied applications. Further, the book gathers and investigates the most recent 5G-based research solutions that handle security and privacy threats while considering resource-constrained wireless devices. The information, applications, and recent advances discussed in this book will serve to be of immense help to practitioners, database professionals, and researchers.
    Schlagwort(e): 5G Mobile Communication ; B5G Networks ; 6G Networks ; Mobile Computation ; Wireless Communication ; Satellite Broadcasting ; Cellular Networks ; Spectrum ; Data Analysis ; Convergence ; Security ; Quality of Service ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFC Electronics: circuits and components ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications ; thema EDItEUR::U Computing and Information Technology::UK Computer hardware::UKN Network hardware
    Sprache: Englisch
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  • 69
    facet.materialart.
    Unbekannt
    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 70
    facet.materialart.
    Unbekannt
    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
    Sprache: Englisch
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  • 71
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2023-08-17
    Beschreibung: This open access short reader investigates how migration has become an increasingly important issue in international relations since the turn of the 21st century. It investigates specific aspects of this migration diplomacy such as double citizenship or bilateral agreements on border controls which can become important tools for bargain or pressure. This short reader also discusses the intersections between migration and international relations concerning issues of global governance such as conflicts and refugees, development and mobility, or environmental migration. The book thereby shows the extent of bargaining involved in migration and international relations, the so called “soft diplomacy of migrations” as seen in the EU/Turkish agreement on borders in 2016, or the EU negotiations with Maghreb or Sub-Saharan countries on read missions against development programs and visas. As such this reader provides a must read to students, academics, researchers and policy makers and everyone who wants to learn more about the international relations aspects of migration governance.
    Schlagwort(e): Citizenship and multiculturalism ; Diasporas and transnationalism ; Refugee crises ; Bilateral agreements on border controls ; Double citizenship ; Conflicts and refugees ; Development and mobility ; Environmental migration ; Migrations policies ; Past refugee crises ; Migration as a soft diplomacy ; Externalization of borders ; Diasporic policies as transnational actors challenging states ; Citizenship in comparative perspective ; Development and migration ; International relations at North-South level ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration
    Sprache: Englisch
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  • 72
    Publikationsdatum: 2024-04-05
    Beschreibung: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Schlagwort(e): RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 73
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    Unbekannt
    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 74
    Publikationsdatum: 2024-04-05
    Beschreibung: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Schlagwort(e): QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Sprache: Englisch
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  • 75
    Publikationsdatum: 2024-04-14
    Beschreibung: This open access book provides a comprehensive treatment of recent developments in kernel-based identification that are of interest to anyone engaged in learning dynamic systems from data. The reader is led step by step into understanding of a novel paradigm that leverages the power of machine learning without losing sight of the system-theoretical principles of black-box identification. The authors’ reformulation of the identification problem in the light of regularization theory not only offers new insight on classical questions, but paves the way to new and powerful algorithms for a variety of linear and nonlinear problems. Regression methods such as regularization networks and support vector machines are the basis of techniques that extend the function-estimation problem to the estimation of dynamic models. Many examples, also from real-world applications, illustrate the comparative advantages of the new nonparametric approach with respect to classic parametric prediction error methods. The challenges it addresses lie at the intersection of several disciplines so Regularized System Identification will be of interest to a variety of researchers and practitioners in the areas of control systems, machine learning, statistics, and data science. This is an open access book.
    Schlagwort(e): System Identification ; Machine Learning ; Linear Dynamical Systems ; Nonlinear Dynamical Systems ; Kernel-based Regularization ; Bayesian Interpretation of Regularization ; Gaussian Processes ; Reproducing Kernel Hilbert Spaces ; Estimation Theory ; Support Vector Machines ; Regularization Networks ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQM Machine learning ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering ; thema EDItEUR::P Mathematics and Science::PH Physics::PHS Statistical physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics::PBTB Bayesian inference ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general::GPF Information theory::GPFC Cybernetics and systems theory
    Sprache: Englisch
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  • 76
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    Frontiers Media SA
    Publikationsdatum: 2023-12-21
    Beschreibung: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Schlagwort(e): R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 77
    Publikationsdatum: 2022-01-31
    Beschreibung: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Schlagwort(e): Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
    Sprache: Englisch
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  • 78
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-04-01
    Beschreibung: This book offers a provocative account of interdisciplinary research across the neurosciences, social sciences and humanities. Setting itself against standard accounts of interdisciplinary 'integration,' and rooting itself in the authors' own experiences, the book establishes a radical agenda for collaboration across these disciplines. Rethinking Interdisciplinarity does not merely advocate interdisciplinary research, but attends to the hitherto tacit pragmatics, affects, power dynamics, and spatial logics in which that research is enfolded. Understanding the complex relationships between brains, minds, and environments requires a delicate, playful and genuinely experimental interdisciplinarity, and this book shows us how it can be done.
    Schlagwort(e): neurosciences ; interdisciplinarity ; social sciences ; interdisciplinary research ; integration ; humanities ; Des Fitzgerald ; Epistemology ; Sociology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 79
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Schlagwort(e): QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Sprache: Englisch
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  • 80
    Publikationsdatum: 2023-12-21
    Beschreibung: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Schlagwort(e): R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 81
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    Springer Nature | Springer
    Publikationsdatum: 2024-04-14
    Beschreibung: This open access two-volume set constitutes the proceedings of the 26th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2020, which took place in Dublin, Ireland, in April 2020, and was held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2020. The total of 60 regular papers presented in these volumes was carefully reviewed and selected from 155 submissions. The papers are organized in topical sections as follows: Part I: Program verification; SAT and SMT; Timed and Dynamical Systems; Verifying Concurrent Systems; Probabilistic Systems; Model Checking and Reachability; and Timed and Probabilistic Systems. Part II: Bisimulation; Verification and Efficiency; Logic and Proof; Tools and Case Studies; Games and Automata; and SV-COMP 2020.
    Schlagwort(e): Software Engineering/Programming and Operating Systems ; Special Purpose and Application-Based Systems ; Computer System Implementation ; Control Structures and Microprogramming ; Mathematics of Computing ; open access ; specification and verification techniques ; software and hardware verification ; SAT and SMT solving ; theorem proving ; model checking ; static and dynamic program analysis ; testing ; system construction and transformation techniques ; tool environments and tool architectures ; abstraction techniques for modeling and verification ; compositional and refinement-based methodologies ; mathematics ; software engineering ; software design ; architecting ; software architecture ; embedded systems ; automata theory ; linguistics ; Software Engineering ; Operating systems ; Expert systems / knowledge-based systems ; Systems analysis & design ; Algorithms & data structures ; Mathematical theory of computation ; Maths for computer scientists ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQE Expert systems / knowledge-based systems ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYD Systems analysis and design ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMB Algorithms and data structures ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYA Mathematical theory of computation
    Sprache: Englisch
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  • 82
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-05
    Beschreibung: This Open Access book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.
    Schlagwort(e): Quantum Physics ; Atomic/Molecular Structure and Spectra ; Astronomy, Astrophysics and Cosmology ; History and Philosophical Foundations of Physics ; Physics, general ; Atomic and Molecular Structure and Properties ; History of Physics and Astronomy ; Philosophical Foundations of Physics and Astronomy ; Physics and Astronomy ; Open Access ; Molecular Beam History ; Precision Measurements ; Femto- and Atto-science ; Foundations of Quantum Mechanics ; Droplet Beams ; Molecular Beam Applications ; Matter Wave Interferometry ; Ultracold Atoms ; Quantum physics (quantum mechanics & quantum field theory) ; Nuclear physics ; Theoretical & mathematical astronomy ; History of science ; Physics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHQ Quantum physics (quantum mechanics and quantum field theory) ; thema EDItEUR::P Mathematics and Science::PH Physics::PHN Nuclear physics ; thema EDItEUR::P Mathematics and Science::PG Astronomy, space and time ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::P Mathematics and Science::PH Physics
    Sprache: Englisch
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  • 83
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Schlagwort(e): QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Sprache: Englisch
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  • 84
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Schlagwort(e): RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 85
    facet.materialart.
    Unbekannt
    Springer Nature
    Publikationsdatum: 2024-03-25
    Beschreibung: Environmental Economics; Climate Change/Climate Change Impacts; Green Development; Environmental Competitiveness; Environmental Coordination; Economy Transformation; Environmental Carrying; Environmental Management
    Schlagwort(e): Environmental Economics ; Climate Change/Climate Change Impacts ; Green Development ; Environmental Competitiveness ; Environmental Coordination ; Economy Transformation ; Environmental Carrying ; Environmental Management ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBC Engineering: general ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WC Antiques, vintage and collectables::WCF Collecting coins, banknotes, medals and other related items
    Sprache: Englisch
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  • 86
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-08
    Beschreibung: This open access book is the first ever collection of Karl Popper's writings on deductive logic. Karl R. Popper (1902-1994) was one of the most influential philosophers of the 20th century. His philosophy of science ("falsificationism") and his social and political philosophy ("open society") have been widely discussed way beyond academic philosophy. What is not so well known is that Popper also produced a considerable work on the foundations of deductive logic, most of it published at the end of the 1940s as articles at scattered places. This little-known work deserves to be known better, as it is highly significant for modern proof-theoretic semantics. This collection assembles Popper's published writings on deductive logic in a single volume, together with all reviews of these papers. It also contains a large amount of unpublished material from the Popper Archives, including Popper's correspondence related to deductive logic and manuscripts that were (almost) finished, but did not reach the publication stage. All of these items are critically edited with additional comments by the editors. A general introduction puts Popper's work into the context of current discussions on the foundations of logic. This book should be of interest to logicians, philosophers, and anybody concerned with Popper's work.
    Schlagwort(e): Karl R. Popper ; Deductive Logic ; Logical Constants ; Proof-theoretic Semantics ; Classical Logic ; Non-classical Logic ; Inferential Definitions ; Mathematical Logic ; Negation ; Modalities ; History of Logic ; L.E.J. Brouwer ; Paul Bernays ; Rudolf Carnap ; Alonzo Church ; Kalman Joseph Cohen ; Henry George Forder ; Harold Jeffreys ; Stephen Cole Kleene ; bic Book Industry Communication::H Humanities::HP Philosophy::HPL Philosophy: logic ; bic Book Industry Communication::U Computing & information technology::UY Computer science::UYA Mathematical theory of computation ; bic Book Industry Communication::P Mathematics & science::PB Mathematics::PBC Mathematical foundations ; bic Book Industry Communication::D Literature & literary studies::DS Literature: history & criticism::DSB Literary studies: general ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTL Philosophy: logic ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYA Mathematical theory of computation ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Sprache: Englisch
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  • 87
    Publikationsdatum: 2024-04-05
    Beschreibung: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Schlagwort(e): RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 88
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    Frontiers Media SA
    Publikationsdatum: 2024-03-29
    Beschreibung: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Schlagwort(e): BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Sprache: Englisch
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  • 89
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    Springer Nature | Springer
    Publikationsdatum: 2024-04-01
    Beschreibung: This open access book describes the latest advances in the anal incontinence diagnostic and therapeutic processes. Anal incontinence is a devastating condition heavily impacting on the patients’ lives. Those suffering from this disorder are generally very embarrassed and reluctant to undergo an appropriate clinical evaluation, thus becoming more isolated and worsening the quality of their life. Luckily, nowadays a wide range of treatments is available to improve this oppressive condition; however, the recognition of the related pathophysiological alterations is mandatory to grant its successful management. This volume will help the surgeons community to keep abreast of developments in diagnostics and treatment of this impairing condition. and will provide all health professionals with the appropriate tools to face this impairing condition.
    Schlagwort(e): Continence mechanism ; Fecal incontinence ; Pelviperineal disorders ; Anal sphincter ; Continence Surgery ; thema EDItEUR::M Medicine and Nursing::MN Surgery ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJH Gastroenterology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJS Urology and urogenital medicine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology
    Sprache: Englisch
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  • 90
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    Unbekannt
    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-14
    Beschreibung: This open access book presents a number of case studies on digital transformation in Norway, one of the fore-runners in the digital progress index established by the European Commission in 2020. They explore the process of adoption, diffusion and value generation from digital technologies, and how the use of different digital solutions has enabled Norwegian enterprises to digitally transform their operations and business models. The book starts with an introductory chapter summarizing a vast body of literature in order to synthesize what is already known about digital transformation before exploring the Norwegian context in more detail. Then a series of case studies from the private and public sector in Norway is presented. They document a process perspective which describes the sequence of events during and after adoption of digital solutions, as well as the types of business value that were realized. Through these single studies, the process of digital transformation is illustrated, a number of key findings highlighted, and eventually theoretical and practical recommendations based on these cases emphasized. The book closes with a brief overview of some emerging technologies, and comments on how they are likely to change different sectors. Digital transformation has been one of the priority areas for the Norwegian government over the past years and puts Norwegian enterprises upfront in adopting novel technologies and utilizing them for achieving organizational goals. This experience accumulated over the years makes the Norwegian context a particularly interesting one in understanding how private and public organizations make use of new digital solutions, what lessons can be learnt during the process, and what are some of the key success and failure factors. This way the book is written for practitioners who are currently involved in digital transformation projects in their organizations, researchers of information systems and management, as well as master students in degrees of informatics and technology management.
    Schlagwort(e): Digital Transformation ; Disruptive Technologies ; Innovation Management ; Digitization ; Digitalization ; Service Science ; Norwegian Industry ; Information Systems ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJQ Business mathematics and systems ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management
    Sprache: Englisch
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  • 91
    Publikationsdatum: 2024-04-05
    Beschreibung: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Schlagwort(e): RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 92
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    Springer Nature | Palgrave Macmillan
    Publikationsdatum: 2024-03-30
    Beschreibung: Ecosystem services; Sustainable development; Environmental management; Natural resource management; Coastal management; Bangladesh and sea-level rise research; Governance of ecosystem services; Regional climate change in South Asia
    Schlagwort(e): Ecosystem services ; Sustainable development ; Environmental management ; Natural resource management ; Coastal management ; Bangladesh and sea-level rise research ; Governance of ecosystem services ; Regional climate change in South Asia ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Sprache: Englisch
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  • 93
    Publikationsdatum: 2024-04-07
    Beschreibung: Mathematics Education, Philosophy of Education, Educational Philosophy
    Schlagwort(e): Mathematics Education ; Philosophy of Education ; Educational Philosophy ; thema EDItEUR::P Mathematics and Science
    Sprache: Englisch
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  • 94
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    Springer Nature
    Publikationsdatum: 2024-04-06
    Beschreibung: fuzzy arithmetic; defuzzyfication; fuzzy prediction models; analysis; trend processing; uncertainty modeling; propagation of uncertainty; Kosinski’s fuzzy numbers
    Schlagwort(e): fuzzy arithmetic ; defuzzyfication ; fuzzy prediction models ; analysis ; trend processing ; uncertainty modeling ; propagation of uncertainty ; Kosinski’s fuzzy numbers ; thema EDItEUR::P Mathematics and Science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Sprache: Englisch
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  • 95
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    Springer Nature | Springer International Publishing
    Publikationsdatum: 2024-04-14
    Beschreibung: This open access book is a practitioner's guide to smart, connected products and solutions. As a hands-on playbook, it combines the business and technical execution perspectives to help product companies, OEMs, manufacturers and equipment operators utilize the full potential of digital enablers, especially Artificial Intelligence (AI), Internet of Things (IoT) and Digital Twins. The Digital Playbook provides comprehensive and actionable guidance, helping to address the challenges of creating sustainable and scalable digital business models, managing cocreation and sourcing, setting up the digital organization, and handling the legal aspects. For the technical execution perspective, the playbook includes the AIoT Framework, which explains how to combine data science and AI engineering with Digital Twins, as well as software development for cloud and edge. The integration with physical product development and retrofit integration of existing equipment is included as well. A pragmatic, agile approach is introduced that takes common agile inhibitors into consideration. A holistic AIoT DevOps approach is described, which combines key elements of DevOps for cloud, edge and AI. Enterprise readiness is ensured by looking at trust and security as well as reliability and resilience for AIoT. A large number of real-world examples and case studies help ensure practical relevance. Readers should have a previous, general understanding of digital strategies and technologies. This book offers readers a clear understanding of the opportunities, as well as the challenges related to building and operating smart, connected products and solutions. They are given a set of tools and blueprints, which they can apply to their practical work in this space. ;
    Schlagwort(e): Artificial Intelligence of Things ; Digital OEM ; Product AI ; AIoT DevOps ; Data management ; agile cloud development ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THR Electrical engineering ; thema EDItEUR::U Computing and Information Technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering::TJFM1 Robotics
    Sprache: Englisch
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  • 96
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    Springer Nature
    Publikationsdatum: 2023-03-03
    Beschreibung: Cardiology; Pediatrics
    Schlagwort(e): Cardiology ; Pediatrics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBD Medical profession
    Sprache: Englisch
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  • 97
    Publikationsdatum: 2022-04-28
    Beschreibung: Urban Ecology; Urbanism; Sustainable Development; Complex Systems; Science, general; International Environmental Law
    Schlagwort(e): Urban Ecology ; Urbanism ; Sustainable Development ; Complex Systems ; Science, general ; International Environmental Law ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques::KJMV Management of specific areas ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology ; bic Book Industry Communication::T Technology, engineering, agriculture::TC Biochemical engineering ; bic Book Industry Communication::W Lifestyle, sport & leisure::WC Antiques & collectables::WCF Coins, banknotes, medals, seals (numismatics)
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    Publikationsdatum: 2023-12-21
    Beschreibung: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Schlagwort(e): R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    facet.materialart.
    Unbekannt
    Springer Nature | Springer Nature Switzerland
    Publikationsdatum: 2024-04-14
    Beschreibung: This open access book presents the proceedings of the 10th Machine Intelligence and Digital Interaction Conference. Artificial intelligence (AI) is rapidly affecting more aspects of our lives as a result of significant advancements in its research and the widespread usage of interactive technologies. This has led to the birth of several new social phenomena. Many nations have been working to comprehend these phenomena and discover solutions for moving artificial intelligence development in the proper direction to benefit individuals and communities at large. These efforts necessitate multidisciplinary approaches, encompassing not only the scientific fields involved in the creation of artificial intelligence and human–computer interaction but also strong collaboration between academics and practitioners. Because of this, the primary objective of the MIDI conference, which was conducted online on December 13–15, 2022, is to combine two up until recently distinct disciplines of research—artificial intelligence and human–technology interaction.
    Schlagwort(e): Computational Intelligence ; AI ; MIDI 2022 ; MIDI ; Machine Intelligence ; Digital Interaction ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence ; thema EDItEUR::U Computing and Information Technology::UN Databases ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQM Machine learning
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Publikationsdatum: 2024-04-05
    Beschreibung: Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different polypeptides and over 80 co-factors. While there have been major advances in understanding the mature structure of this photosystem many key protein factors involved in the assembly of the complex do not appear in the holoenzyme. The mechanism for assembling this super-complex is a very active area of research with newly discovered assembly factors and subcomplexes requiring characterization. Additionally the ability to split water is inseparable from light-induced photodamage that arises from radicals and reactive O2 species generated by Photosystem II chemistry. Consequently, to sustain water splitting, a “self repair” cycle has evolved whereby damaged protein is removed and replaced so as to extend the working life of the complex. Understanding how the biogenesis and repair processes are coordinated is among several important questions that remain to be answered. Other questions include: how and when are the inorganic cofactors inserted during the assembly and repair processes and how are the subcomplexes protected from photodamage during assembly? Evidence has also been obtained for Photosystem II biogenesis centers in cyanobacteria but do these also exist in plants? Do the molecular mechanisms associated with Photosystem II assembly shed fresh light on the assembly of other major energy-transducing complexes such as Photosystem I or the cytochrome b6/f complex or indeed other respiratory complexes? The contributions to this Frontiers in Plant Science Research Topic are likely to reveal new details applicable to the assembly of a range of membrane-protein complexes, including aspects of self-assembly and solar energy conversion that may be applied to artificial photosynthetic systems. In addition, a deeper understanding of Photosystem II assembly — particularly in response to changing environmental conditions — will provide new knowledge underpinning photosynthetic yields which may contribute to improved food production and long-term food security.
    Schlagwort(e): QK1-989 ; Q1-390 ; Arabidopsis thaliana ; photoactivation ; photosynthesis ; Chlamydomonas reinhardtii ; cyanobacteria ; biogenesis ; Photosystem II ; photodamage ; Nicotiana tabacum ; Synechocystis sp. PCC 6803 ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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