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  • Nature Publishing Group  (47,695)
  • Springer Science + Business Media
  • 1995-1999  (12,082)
  • 1980-1984  (17,607)
  • 1975-1979  (18,006)
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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 2 (1995), S. 28-35 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Using the two-hybrid protein interaction reporter system, actin, profilin, Srv2p and two SH3-containing proteins are found to bind yeast actin in vivo. When tested for ability to interact with 35 actin mutations distributed over the monomer surface, distinct subsets of mutations characteristic for ...
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  • 2
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    [s.l.] : Nature Publishing Group
    Nature structural biology 2 (1995), S. 69-76 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The crystal structure of the phosphoglycerate dehydrogenase from Eschehchia coli is unique among dehydrogenases. It consists of three clearly separate domains connected by flexible hinges. The tetramer has approximate 222 symmetry with the principal contacts between the subunits forming between ...
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  • 3
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    [s.l.] : Nature Publishing Group
    Nature structural biology 2 (1995), S. 77-80 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The average contact distance between protein and solvent surface atoms in cubic insulin crystals has been determined from two sets of 15 Å resolution neutron diffraction data. A contact distance between the water hydrogen sites and the protein surface that is significantly shorter than the ...
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  • 4
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 729-730 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The requirements for any such "geological" experiment are that the interacting material has been sufficiently deeply buried that the neutrino effect is not swamped by cosmic-ray interactions, that the cover has been in place long enough for any previously produced 81Kr to decay, that the ...
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  • 5
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 732-733 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Consider a plot of the emission line width (for example, the full width at half maximum intensity, FWHM) of a specified spectral line against the redshift of a QSO. Assuming that all QSOs are intrinsically identical, and are at cosmological distances corresponding to their redshifts, the FWHM of a ...
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  • 6
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 735-736 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Visibility in a polluted atmosphere is determined primarily by the total scattering coefficient (bscat) of the ambient aerosol6. As part of the California Aerosol Characterisation Study (ACHEX)7, the scattering coefficient, mass concentration, and chemical composition of the Los Angeles aerosol ...
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  • 7
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 734-735 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The maximum thermodynamic efficiency permitted for extracting energy from direct sunlight must be higher than that permitted for diffuse sunlight of the same intensity, since loss of directivity is evidently an irreversible process. But what are the numerical values of these two maximum ...
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  • 8
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 739-740 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have determined the concentration of 241Am in surface waters of the Mediterranean Sea, collected from several stations covered during the 1975 cruises. The detailed analytical procedures employed were described by Ballestra et al.4. Briefly, 241Am together with plutonium isotopes were ...
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  • 9
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 740-742 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Furthermore, infrared spectra of phosphate adsorbed on goethite show differences according to the suspension pH at which the sample was prepared1,3. These probably arise from different states of protonation of the adsorbed phosphate, but the results have been difficult to interpret. The possibility ...
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  • 10
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 746-748 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To further confirm and generalise the original observation, new materials were prepared. A woman was filmed while she fixated a television camera lens and repeated ba-ba, ga-ga, pa-pa or ka-ka. Each utterance was repeated once per second, with an interval of approximately 0.5s between repetitions. ...
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  • 11
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 742-744 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The stratigraphy of the Teindland profile as described by FitzPatrick may be summarised as follows. The section showed at the top a semi-podsol in 2?2.4 m of sandy till and outwash gravel which overlay a fossil iron podsol developed in fluvioglacial outwash. The upper part of the buried soil which ...
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  • 12
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 753-754 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Data were obtained from 8 barn owls (Tyto alba) which had been hand-raised indoors. Six had relatively normal early visual experience in the laboratory and provided control data for this study in addition to detailed data presented elsewhere1. The ages of the 6 normal owls ranged from 1 to 7 years. ...
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  • 13
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 757-758 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Proteus bacteria are unusual in that they readily swarm out from the inoculum point on the surface of most agar media. Despite study by many workers there are several aspects of this swarming that are not understood. We have been considering one of these aspects, namely the behaviour of two swarms ...
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  • 14
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 760-762 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Since it has proved difficult to grow the tumour cells from primary human breast carcinomas8,9, we have begun by examining contact-dependent communication between human mammary fibroblasts (HumF) cultivated from ex-plants of terminal ducts, and human mammary epithelial cells (HumE) cultured by the ...
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  • 15
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 762-764 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The ubiquitous occurrence of gap junctions in vivo suggests that junctional integration is a widespread phenomenon, but one can conceive of instances where integration is a disadvantage and independence is important. Such situations would require specificity of junctional communication to ...
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  • 16
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 764-767 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cultures were made from stored frozen aliquots of uncultured cell suspensions from mechanically disrupted fibroadenomas removed in the ICRF Breast Unit at Guy's Hospital. The suspensions, which consisted predominantly of clusters of 10?100 cells were distributed in growth medium (see legend to Fig. ...
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  • 17
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 770-771 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] All experiments utilised heparinised human peripheral blood sedimented in 5% dextran. The leukocyte-rich plasma was layered onto a ficoll-hypaque gradient and centrifuged at 700g for 45 min. Separated cells were washed three times in Dulbecco's phosphate-buffered saline and resuspended at a final ...
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  • 18
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The rationale behind the present approach reads as follows. Lymphocytes carry on their surface idiotypic, antigen-binding receptors signifying their potential immune reactivity. To obtain the particular subpopulation carrying receptors with specificity for a given antigen in a pure form two steps ...
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  • 19
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We took advantage of two available model systems which utilise rats sensitised to nervous tissue-adjuvant emulsions. The first involves adult Buffalo strain rats bearing designated Morris hepatomas which produce diverse amounts of AFP12, and the second involves the diminished occurrence of EAE in ...
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  • 20
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 780-782 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 The effect of 48 h of preculture of spleen cells with DNP-polysaccharide conjugates on the frequency of precursors responding to 0.1 µg ml?1 TNP-LPS.l 107 spleen cells ml?1 from normal CBA mice were incubated with various conjugates in 50 mm tissue culture dishes (Falcon) in 5-ml ...
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  • 21
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 787-789 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Injections of botulinum toxin, denervation or control procedures were carried out in 148 female Sprague-Dawley rats (190?215g) under chloral hydrate anesthaesia (400 mg kg?1). Botulinum toxin (supplied by Dr E. Schantz), freshly diluted in Ringer solution, was injected into the right extensor ...
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  • 22
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The methodology has been described in detail elsewhere14,15. Briefly, female rats of an inbred Wistar strain (TNO, Zeist, The Netherlands) had plastic canulae implanted in the 3rd cerebral ventricle, 1 week before the observation session. The behavioural procedure consisted of a 15th-s sampling ...
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  • 23
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 795-796 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] At 3 d of age the serum progesterone concentration was ten times greater in female pups than in males (Table 1) and the adrenal progesterone concentration was also significantly greater in the neonatal females. Administration of pregnant mare serum gonadotropin (PMSG, which has both follicle ...
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  • 24
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 792-794 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] C-Fragment was isolated from pig pituitary glands as described previously2. Cannulae were implanted in the lateral ventricles of male Wistar rats weighing 150?170 g10. After a recovery period of at least 1 week, response latencies of the animals were measured on a hot plate (54.2 ± 0.2 C) ...
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  • 25
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The haemoglobin types of the sheep (Border Leicester Suffolk cross) used in this investigation were either AB or BB. A carotid or femoral artery of the foetuses was cathe-terised between 108 and 124d gestation7, and blood samples were obtained from this time up to birth at 139?144 d and from the ...
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  • 26
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 804-806 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male Long-Evans rats, aged 2 months, were used in all experiments. Conditions for surgery and animal maintenance have been described2. Livers were quickly excised from decapitated animals and homogenised using a loose-fitting Dounce homogeniser in 3 vol of cold Medium A (0.25 M sucrose, 0.05 M ...
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  • 27
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    Nature 264 (1976), S. 803-804 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To trace the evolutionary improvement of an enzyme in molecular terms and to watch the stepwise development of its catalytic apparatus, we need an enzyme susceptible to directed selective pressure towards an altered catalytic function. So that mutational changes may be fully inter-pretable, the ...
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  • 28
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 811-811 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the letter ?Stab initiation of explosions? by M. M. Chaudhri (Nature, 263, 121; 1976) the expression giving q1 in equation (2) should be q1=[1+ ?( ?/2 ? v(1-sin215o)Rpc)/4]- ...
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  • 29
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    Nature 264 (1976), S. 814-814 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SALIVARY ?IgA Immunoconglutinins?, which reportedly bind both altered and native C3, have generated considerable interest1,2. Unfortunately, the methods so far described for their purification are somewhat cumbersome, as they involve incubation of complement-coated sensitised sheep cells with ...
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  • 30
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 813-813 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MCHENRY AND CORRUCCINI REPLY ? The discussion here1 is about different fossils. We show that taken together the relative proportions of the proximal ends of KNM-ER 1481 and 1472 are distinguishable from those of SK 82 and 97 and KNM-ER 1504. Wolpoff argues1 that the reconstructed femoral head ...
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  • 31
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    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 815-815 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] COMPARED with many parts of the Solar System, the Earth is a protean creature, in a constant state of change. With such activity and destruction, Earth-bound geologists can never hope to find a landscape carpeted, as on the Moon, with fragments which have lain undisturbed for 3,000 Myr. Yet just ...
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  • 32
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    Nature 264 (1976), S. 816-816 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EDWARD GOLDBERG?S book arose as a result of a recommendation made in 1973 at the time of the first meeting of the Intergovernmental Oceanographic Commission?s International Coordination Group for the Global Investigation of Pollution in the Marine Environment. As originally conceived, it was ...
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  • 33
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    Nature 264 (1976), S. 817-817 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] POSSIBLY because this book arrived on my desk around holiday time I viewed it as a sort of tourist menu attempting to offer a wide array of characteristic foods as an introduction to the culinary arts of a new country. The broad title is perhaps a little misleading for the bulk of the book presents ...
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  • 34
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    Nature 264 (1976), S. 816-816 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WHEN Donald L. Lee wrote the first edition of this book it was a milestone. Although of modest size, it was the first attempt to organise the subject, stimulated great interest and highlighted critical areas for the research efforts of others. Now, with his colleague, Howard J. Atkinson, a second ...
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  • 35
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    Nature 264 (1976), S. 818-818 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The World Computer Chess Championship. Stockholm, 1974. By Jean E.Hayes and David N. L.Levy Pp. v+105. (Edinburgh University: Edinburgh, May 1976.) £3.75. THE first World Computer Chess Championship took place in Stockholm in August 1974, and resulted in a closely contested victory for the ...
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  • 36
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    Nature 264 (1976), S. 820-820 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Dr William Nordberg, internationally known space scientist and Director of Applications at NASA?s Goddard Space Flight Centre, near Washington, D.C., died on October 3, after a two year illness, from cancer. Born in 1930, Dr Nordberg was educated at the University of Graz in Austria, his native ...
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    Nature 264 (1976), S. 819-820 
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    Notes: [Auszug] Lars Onsager, who died on October 5, 1976, was undoubtedly one of the great scientists of the 20th century. His publications were neither lengthy nor numerous. When he was awarded the Nobel prize in Chemistry for 1968 for his discovery of ?Reciprocal relations in irreversible processes?, the ...
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  • 38
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    Nature 263 (1976), S. 195-198 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Clinical trials with negative-pion beams for cancer radiotherapy will begin soon at four special facilities in the USA, Canada, and Switzerland. Negative pions are elementary particles which can be produced in high energy accelerators and which have properties that make them seem promising as a new ...
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  • 39
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    Notes: [Auszug] Adipokinetic hormone, isolated from locust corpora cardiaca, has been identified as a blocked pep-tide : PCA–Leu–Asn–Phe–Thr–Pro–Asn–Trp–Gly–Thr–NH2. The detailed structure is based on mass spectrometric data, substantiated in ...
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  • 40
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    Nature 262 (1976), S. 629-630 
    ISSN: 1476-4687
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    Notes: [Auszug] HAM REPLIES?According to our best judgment, there are at least three types of radiation damage to the retina in the spectral range, near infrared to near ultraviolet (1,400?400nm). These are: sonic transient or shock damage from picosecond to nanosecond pulses1?2, thermal damage (independent to a ...
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  • 41
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    Nature 262 (1976), S. 633-633 
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    Notes: [Auszug] THE appearance of this book is a major archaeological event. As the list of ?Works cited in the text? shows, Professor Clark has devoted much of his academic life to the study of the economic basis of Prehistoric Europe, and in particular the material from Scandinavia. This book typifies his ...
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  • 42
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    Nature 262 (1976), S. 634-634 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] David Clarke, who died in Cambridge on June 28, after a short illness, was a rare, almost unique figure in the academic world: he was a theoretical archaeologist. At the age of only 38 he had already established an international reputation, largely as a result of the massive volume entitled ...
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  • 43
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    Nature 262 (1976), S. 431-431 
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    Notes: [Auszug] TEN thousand, a hundred thousand, a million dead in the latest earthquake at Tangshan in China? It seems as if the Chinese authorities are not at present going to talk about the scale of the disaster, maybe believing that details of fatalities will produce some sort of ghoulish exultation in other ...
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  • 44
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    Nature 262 (1976), S. 632-632 
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    Notes: [Auszug] THE Iversens? marriage of neuro- and psychopharmacology has produced a remarkably sophisticated, yet readable, text on behavioural pharmacology. The text is self-contained and appropriate for advanced undegraduate or first-year graduate students. A wide spectrum of drugs are included: amphetamines, ...
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  • 45
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    Nature 263 (1976), S. 131-132 
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    Notes: [Auszug] Two common alleles of esterase-6 exist in natural populations as a stable polymorphism. In addition, several rare electrophoretic variants, null alleles and heat-stability alleles have been reported9?15 The nomenclature of Franklin15 has been used for esterase-6 alleles. My results show that, in ...
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    Nature 262 (1976), S. 440-440 
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    Notes: [Auszug] THE well-known French-Canadian science broadcaster Fernand Seguin resigned from the Science Council recently when it would not publish his dissenting views on a council report on population, technology and resources. The report calls for a sharp reduction in immigration to slow Canada's population ...
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    Nature 262 (1976), S. 442-442 
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    Notes: [Auszug] SIR,We fully support the contention of Walton and Spooner (June 17, pages 5335) that there is a pressing need to identify further resources of lithium, but would take issue with them on a few points. In Table 2 some 50% of their total resources derives from North American brine deposits. However, ...
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    Nature 262 (1976), S. 443-444 
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    Notes: [Auszug] ONE of the most recent concepts emerging from the witches brew of present-day immunology is the exciting possibility that antibodies directed against the receptor sites of other antibodies may have a role in regulating the immune response. It is more than a decade ago that Oudin and Michel (C.r. ...
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    Nature 262 (1976), S. 479-481 
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    Notes: [Auszug] Though the part played by fulvic acids and other low molecular weight organic acids in weathering has been widely documented, the action of humic acids in these processes has been examined in only a few cases. Schalscha et al.5 extracted considerable amounts of Fe from minerals treated with humic ...
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    Nature 262 (1976), S. 484-485 
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    Notes: [Auszug] Lake Ndutu is the smaller of the two (Lake Masek had enough water during the dry season of 1974?September?November?to support a resident population of hippopotami), and shows very marked fluctuations in water level between the wet and dry seasons. During the wet season the whole lake shore is under ...
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    Nature 262 (1976), S. 491-493 
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    Notes: [Auszug] Whether the observed heterozygosity agrees with the above theoretical value or not is, in practice, however, very difficult to examine, since the exact values of Nc and v in a population are hardly obtainable. Recently, it was shown8,9 that the variance of single locus heterozygosities is given by ...
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    Nature 262 (1976), S. 502-504 
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    Notes: [Auszug] The experiments were done on microdissected islets of the mouse pancreas as described previously2. The islets were continuously perifused in a small Plexiglas chamber (volume 1 ml) with a KrebsHenseleit solution gassed with 95% O2 and 5% CO2. The temperature was kept constant at 37 C. The basal ...
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    Nature 262 (1976), S. 504-505 
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    Notes: [Auszug] Sciatic nervesartorius muscle preparations were isolated from frogs (Rana nigromaculatd). Conventional intracellular recording techniques and a voltage clamp circuit were as used previously11. Ionic composition of Ringer's solution was as follows (mM): NaCl, 115; KCl, 2.0; CaCl2, 1.8; NaH2PO4, 0.7; ...
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    Nature 263 (1976), S. 140-142 
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    Notes: [Auszug] As shown before20?22, quiescent CEF initiate DNA synthesis 6?8 h after exposure to insulin or serum. Based on the incorporation of 3H-thymidine into trichloroacetic acid (TCA)-insoluble material, the highest levels of DNA synthesis were initiated by insulin at a concentration of 1?5 µg ml?1 ...
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    Nature 262 (1976), S. 519-520 
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    Notes: [Auszug] A particularly simple and convenient route to conjugates of proteins with random copolymer amphipaths is shown in Fig. 1. A linear hydrophilic polymer such as the non-cross-linked types of ethylene-maleic anhydride copolymers previously used for enzyme immobilisation7,8 or the maleic ...
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    Nature 262 (1976), S. 516-519 
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    Notes: [Auszug] Here we examine whether two types of condensed chromatinmitotic chromosomes and the fraction of interphase chromatin that contains satellite DNAhave the same subunit structure as non-condensed chromatin. The experiments were performed on cells of Dipodomys ordii (kangaroo rat) because (1) mitotic ...
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    Nature 262 (1976), S. 522-522 
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    Notes: [Auszug] WHEN students start research on a particular topic in theoretical physics their first problem is to learn all the essentials of previous work in a finite time. This nearly impossible task is helped by providing them with courses of lectures in which early developments are outlined and more recent ...
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    Nature 263 (1976), S. 145-146 
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    Notes: [Auszug] Three fibre-blast lines were used: human lung fibroblasts (from 13-weekembryos) obtained from Gibco-Biocult (Paisley, Scotland); human skin fibroblasts (from 14?16-week embryos) and rat skin fibroblasts (from 16?18-day embryos) cultured in this laboratory. All cell lines were grown in air on glass ...
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    Nature 263 (1976), S. 148-149 
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    Notes: [Auszug] Table 1 Description of experimental groups Daily light-dark Group No. of males Courtship condition (LD) cycle (h) 1 10 Isolation* 14:10 2 10 Isolation 8:16 3 10 Brief courtship? 14:10 4 10 Brief courtship 8:16 5 10 Breeding? 14:10 * Males were housed individually in isolation ...
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    Nature 262 (1976), S. 353-356 
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    Notes: [Auszug] Recent work has clarified how different erythroid functions may be regulated during normal erythropoiesis, and have helped to define the role of the hormone erythropoietin. Studies with cell lines (Friend cells) capable of undergoing erythroid differentiation in culture have made possible a ...
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    Nature 262 (1976), S. 363-369 
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    Notes: [Auszug] A comparison of the crystal and the solution structure of yeast tRNAPhe has been carried out by calculating the low field NMR spectrum from refined X-ray structure coordinates. The similarity between the computed and observed spectra show that the crystal and solution structure are ...
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    Nature 262 (1976), S. 369-370 
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    Notes: [Auszug] Table 1 Flux densities in each channel Average flux densitiest? Relative flux densities? c??/?0* (Jy) (Jy) (km s?1) ?short? (50") ?long? (20") ?short? (50") ?long? (20") 8,085 10.86 9.37 ?0.039 ?0.053 8,126 10.62 9.14 ?0.285 ?0.291 8,167 10.89 9.41 ?0.013 ?0.017 ...
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    Nature 262 (1976), S. 373-374 
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    Notes: [Auszug] Fig. 1 The Santorini Group in the Aegean Sea, Greece. The old ring-islands Thera and Therasia surround the late-Minoan Santorini caldera and the post-Minoan Kameni islands. P, location of the schematic profile (Fig. 2). The Bo palaeosol is spread all over Thera and Therasia. Its thickness locally ...
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    Nature 262 (1976), S. 378-379 
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    Notes: [Auszug] Table 1 Data on relative plate motion (adapted from Kaula6) Boundary type Length(km) Assumed width (km) Mean transverse velocity (cm yr?1) μ (dyne) cm?2) Contribution to M0 (tot) (dyne cm) Ocean subducted under ocean 13,100 200 4.07 6 x 1011 0.64 x 1029 Ocean subducted under ...
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    Nature 262 (1976), S. 381-382 
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    Notes: [Auszug] The adhesion of rubber depends markedly on the roughness of the surface with which it is in contact4,5. Slight roughness can increase the adhesion compared with an ideally smooth surface, while larger values of roughness can greatly reduce it6. When a cylinder rolls on clean rubber, the two ...
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    Nature 262 (1976), S. 384-386 
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    Notes: [Auszug] W. smithii is found from the Gulf coast to Labrador and northern Manitoba3?6 where it confines its breeding site to the water-filled leaves of a single species of plant, Sarracenia purpurea. The larvae overwinter in the pitchers in a state of developmental arrest. Short days evoke and maintain, ...
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    Nature 262 (1976), S. 388-390 
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    Notes: [Auszug] It is now possible to create hydra which are virtually free of nerve cells, by treating the animals with colchicine12. Colchicine causes the endodermal digestive cells to send processes through the mesoglea and engulf ectodermal nerve cells, interstitial cells and nematoblasts, and draw them into ...
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    Nature 262 (1976), S. 393-394 
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    Notes: [Auszug] Stomata of C. communis have a complex structure with a number of subsidiary cells (Fig. 1). K+ and Cl? concentrations in each type of cell have been determined for stomata in both the open and closed states4,6. There seemed to be considerable transport of K+ and Cl? between the cells during opening ...
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    Nature 263 (1976), S. 153-154 
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    Notes: [Auszug] Fig. 1 Inhibitory postsynaptic current (i.p.s.c.) recorded at various membrane potentials. A, Superimposed i.p.s.c. at stimulation rate of 16 Hz: a, ? 37 mV; b, ?46 mV; c, ?57 mV; d, ?79 mV; e, ?90 mV. Upward deflection indicates the inside current. B, Train of i.p.s.c.s produced at 107 Hz: a, ?47 ...
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    Nature 263 (1976), S. 155-156 
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    Notes: [Auszug] The pacemaker potential in cardiac Purkinje fibres is generated by a time-dependent deactivation of a slow outward current, tea1,2 which allows the time-independent steady-state inward current to depolarise the membrane. Using the formalism of Hodgkin and Huxley3 this current component is described ...
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    Nature 262 (1976), S. 421-422 
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    Notes: [Auszug] The thickness, and therefore the specific electrical capacitance, of planar bilayer membranes3 depends strongly on temperature4,5, because the bilayer concentration of alkane solvent (used to form the bilayer) is temperature dependent. The bilayer is believed to be in physicochemical equilibrium ...
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    Nature 262 (1976), S. 425-425 
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    Notes: [Auszug] Branch of sacred sycomore or mulberry fig (Ficus sycomorus) from a 20th dynasty Egyptian tomb. The tree is ?not indigenous but (has been) cultivated in Egypt since times immemorial. It originates from Arabia and Somaliland. Its ancient name was Nehet-entep, and its fruits have been found in tombs ...
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    Nature 262 (1976), S. 427-427 
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    Notes: [Auszug] THE uptake of ions by plant roots is a subject which over the years has probably had more man-hours devoted to it than any other single aspect of plant physiology. In consequence an extensive, very diverse and often contradictory literature has accumulated. From time to time courageous individuals ...
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    Nature 262 (1976), S. 339-339 
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    Notes: [Auszug] "If JET goes to Ispra, it is better that it does not get done at all." Senior official, Culham fusion research centre. "If JET does not go to Ispra, it is not worth doing." Senior official, European Commission. Culham and Ispra are probably the two main contending sites for the JET project. ...
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    Nature 262 (1976), S. 251-251 
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    Notes: [Auszug] ? The State Committee of Supply (Gossnab) of the Soviet Union is holding up scientific progress, a recent Pravda editorial has implied. Soviet policy is, of course, committed to the idea of the scientific and technical revolution as the panacea for social and economic ills, but according to Pravda ...
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    Nature 262 (1976), S. 252-252 
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    Notes: [Auszug] ESA scientific programme The European Space Agency is in the process of selecting its future scientific satellite and shuttle payloads. Studies of 16 possible projects were presented to European scientists at the end of last month in Paris. The astronomy and solar system working groups ...
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    Nature 262 (1976), S. 255-256 
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    Notes: [Auszug] ONE of the most fascinating differences in the organisation of DNA in eukaryote cells (those with a distinct nucleus) from that in prokaryotes (bacteria and blue-green algae) is the abundant occurrencein higher eukaryotes at leastof long palindromes. When applied to nucleotide sequences in ...
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    Nature 262 (1976), S. 246-247 
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    Notes: [Auszug] WHEN it was published in 1972, The Limits to Growth was a kind of landmark, crystallising in a mathematical model the views of those who believed that the would had come to a turning-point in its profligate use of resources, its growing (pollution of the environment, and its inexorable population ...
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    Nature 262 (1976), S. 248-248 
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    Notes: [Auszug] GROWING doubts about the future of the British-designed Steam Generating Heavy Water Reactor (SGHWR) have led the House of Commons Select Committee on Science and Technology to call an inquiry into progress on the reactor system, now at the end of the design stage. The committee two years ago ...
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    Nature 262 (1976), S. 352-352 
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    Notes: [Auszug] THE question of how different types of aggression in animals are related to one another has been a source of continual controversy. Aggressive behaviour in natural conditions is usually seen in competitive social encounters 'between members of the same species, for example in territorial defence ...
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    Notes: [Auszug] THE name of sassafras tea conjures up thoughts of early days in North America, of folk medicine, and of a tree whose leaves, charmingly enough, grow in three different shapes on the same branch?some are three-fingered, some are mitten-shaped, and some are just oval. The name is Spanish, but the ...
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    Nature 262 (1976), S. 253-253 
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    Notes: [Auszug] SIR,We were interested to see Anthony Harris's measurements of asymmetry in young women (May 6, page 10) and the response of Connolly and Dangerfield (May 20, page 188), and have found our ratios right to left of ankle 1.006, calf 1.02, biceps 1.04, wrist 1.02. We conclude, assuming we are average ...
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    Notes: [Auszug] Fig. 1 Time course of RNA release from isolated nuclei. All experiments were carried out at 35 C in the following medium13: 50 mM Tris-HCl, pH 7.6, 25 mM KC1, 2.5 mM MgCl2, 0.3 mM MnCl2,0.5 mM CaCl2, 5.0 mM NaCl, 2.5 mM K2HPO4, 5.0 mM spermidine and 2.0 mM dithioerythrytol. O, Control; , release ...
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    Nature 262 (1976), S. 287-289 
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    Notes: [Auszug] An extract of OKl flies, a strain from Oklahoma that shows male recombination12, was prepared by homogenising together 10 each of newly emerged males and females in 4ml of Drosophila Ringer solution, and centrifuging at 2,000 r.p.m. for 2 min. The supernatant was injected into virgin females which ...
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    Nature 262 (1976), S. 295-296 
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    Notes: [Auszug] Fig. 1 Survival of Lew.lA skin grafts after treatment with Lew.lA serum (?), AVN serum (O), untreated controls (?). This study was designed to determine whether transplantation tolerance in rats can be induced by multiple massive doses of serum. Rats of the AVN strain were injected with allogeneic ...
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    Nature 262 (1976), S. 271-272 
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    Notes: [Auszug] Two outbursts of T CrB have been observed, in 1866 (JD 2,402,734) and in 1946 (JD 2,431,861), these being apparently remarkably similar5. In neither case was the eruption detected before the nova was already declining in brightness, but evidence exists suggesting that the initial rise is ...
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    Nature 262 (1976), S. 303-305 
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    Notes: [Auszug] For model membrane studies, various molar mixtures of cholesterol, dipalmitoyl phosphatidylcholine and natural phosphatidylserine (extracted from bovine brain)8 were used. The chloroform solution of the lipids were spread as monomolecular layers on the surface of the liquid subphase in a Langmuir ...
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    Notes: [Auszug] We established sympathetic neuronal networks by dissociating the SCG from perinatal rats by a method previously described9, but without antimitotic agents to suppress non-neuronal cell growth. In these conditions a substantial number of non-neuronal cells are present although these do not develop ...
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    Nature 262 (1976), S. 314-316 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Agar growth and tumorigenicity of cultures derived 138-145 d after exposure to ENU or buffer Average no. of Plating No. of animals Average time Culture Passage level colonies per efficiency Passage level with tumours/ before 104 cells plated inagar(%) No. ...
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    Nature 262 (1976), S. 318-319 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Yields of phytoalexins from V. faba pod endocarp tissue bearing limited lesions caused by B. cinerea 4 d after fungal inoculation Phytoalexin Yield (μg per g fresh tissue) Wyerone 217 Wyerone acid 219 Wyerone epoxide 30.7 Medicarpin 19.5 Fig. 1 a, Wyerone acid (R = H); ...
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    Nature 263 (1976), S. 176-176 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Electrolyte Chemistry of Organic Solutions? No, that will not do either; the title is strange and ill-chosen. The book's aim, according to the author, is to provide the organic chemist with everything he needs to know about electrolyte solutions, to treat all important solution chemistry ...
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    Nature 262 (1976), S. 329-329 
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    Notes: [Auszug] A RECENT report by Bird and Galvin1 has described experiments in which specimens of En 31 steel were immersed in solutions of zinc dialkyldithio-phosphates in white oil and either heated over a range of temperatures for 16 h or rubbed for 10 min against a disk of the same material. Electron ...
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    Nature 262 (1976), S. 330-330 
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    Notes: [Auszug] BRAY REPLIESThe main point of Francis1 is that the evidence of late Pleistocene and Holocene volcanism in southern South America2 is based on a small number of published radiocarbon dates. The reason I originally included the southern South America volcanic data was that both the radiocarbon-dated ...
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    Nature 263 (1976), S. 177-177 
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    Notes: [Auszug] FEW of the ?broad survey? books on energy that are now flooding the market focus with such admirable clarity, thoroughness and wide scope as does this on the hard-nosed physics and engineering of the subject. Aimed at university courses and the more numerate specialists, the emphasis is ...
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    Nature 262 (1976), S. 313-314 
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    Notes: [Auszug] Slices of rat neostriatum were incubated for 15min at 37 C in Krebs-Ringer bicarbonate buffer containing 1 mM isobutylmethylxanthine (IBMX) (a potent phospho-diesterase inhibitor) and added drugs, as previously described by Forn et al7 (see legend to Fig. 1). Cyclic AMP and cyclic GMP in boiled ...
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    Nature 262 (1976), S. 335-335 
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    Notes: [Auszug] Appointments Professor J. E. Enderby to the Chair of Physics at the University of Bristol. Dr H. K. Moffart to the Chair of Applied Mathematics at the University of Bristol. Professor D. L, Gardner to the Chair of Histopathology at the University of Manchester. Dr T. B. Grimley and Dr A. Ledwith ...
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    Nature 262 (1976), S. 162-163 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RELIABLE weather forecasts for a week or so ahead would be of great economic value; almost every industry, including agriculture, transport, building, shipping, fuel and power, would benefit in the planning of operations and, of course, the general public would be better able to plan outdoor ...
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    Nature 262 (1976), S. 167-167 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ● Brazilian engineers have now succeeded in modifying an automobile engine to run on pure alcohol. This could be significant in solving energy problems here, in view of the fact that Brazil imports more than 80% of the crude oil it uses for making petrol. The experimental engine, installed in a ...
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    Nature 262 (1976), S. 170-170 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] US export moratorium ? Proliferation of the international trade in nuclear technology is "very rapidly becoming a major political issue in the United States", Mr Llewellyn King, Editor of Weekly Energy Report, told the Financial Times conference on nuclear power last week. Hearings set for July 20 ...
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    Nature 262 (1976), S. 172-173 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EVER since the subject began, protein crystallographers have been complaining that they work for a long time on a project without obtaining any significant information and then, literally overnight, they are overwhelmed with information. The source of this surfeit of data is the electron density ...
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