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  • Nature Publishing Company
  • 1990-1994  (1,972)
  • 1
    Electronic Resource
    Electronic Resource
    Protropin and Public Opinion (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 847-847 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Protropin, Genentech's genetically engineered human growth hormone, has sprouted a big problem—a U.S. federal grand jury indictment charging a Minneapolis, MN physician, a Genentech marketing executive, and Caremark, Protropin's distributor, with engaging in a million-dollar prescription drug ...
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    URL: http://dx.doi.org/10.1038/nbt0994-847
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  • 2
    Electronic Resource
    Electronic Resource
    Environmentally Correct Biotechnology (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 850-850 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “Biotechnology entails the harnessing of organisms or their components to undertake specific processes thatare, in principle, advantageous to society. There are many applications of biotechnology in fields as diverse as medicine, agriculture, industry, and resource recovery and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-850
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  • 3
    Electronic Resource
    Electronic Resource
    BioChem Pharma's big push into diagnostics (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 854-855 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—BioChem Pharma (BCP, Laval, Quebec) has been busy as of late. Its majority-owned subsidiary, BioChem ImmunoSystems, purchased most of the diagnostics business of Ares-Serono (Geneva) for $61 million. Also, BCP announced that it was planning to sell almost half of its 38 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-854
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  • 4
    Electronic Resource
    Electronic Resource
    Going public boosts executive compensation (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 860-860 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—It pays for U.S. biotech companies to go public, at least as far as executive compensation goes. Indeed, biotech executives at the smaller U.S. public companies—a ranking that excludes the 20 public companies with the biggest market capitalizations—currently make annual ...
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    URL: http://dx.doi.org/10.1038/nbt0994-860
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  • 5
    Electronic Resource
    Electronic Resource
    EU plans to streamline GMO regulations (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 864-864 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] OXFORD—The European Union's (EU, Brussels) European Commission (EC)—the EU's regulation-drafting body—is preparing to streamline the regulations governing the contained use of genetically modified organisms (GMOs) and the deliberate release into the environment of GMOs. Indeed, ...
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    URL: http://dx.doi.org/10.1038/nbt0994-864
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  • 6
    Electronic Resource
    Electronic Resource
    Transgene Inactivation: Plants Fight Back! (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 883-888 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Desirable new phenotypes created by the introduction of foreign DNA into plants are frequently unstable following propagation, leading to a loss of the newly acquired traits. This genetic instability is due not to deletion or mutation of the introduced DNA but rather to the inactivation of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-883
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  • 7
    Electronic Resource
    Electronic Resource
    Enzymatic Separation of High–Quality Uninked Pulp Fibers from Recycled Newspaper (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 905-908 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a novel process for the separation of uninked from inked fibers in old newspaper (ONP). The process consists of two connected batch reactors in which ONP is pulped in one with the enzyme, cellulase. After several hours, uninked pulp fibers are retained in one vessel by means of a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-905
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  • 8
    Electronic Resource
    Electronic Resource
    Herbicide Resistant Turfgrass ( Agrostis palustris Huds.) by Biolistic Transformation (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 919-923 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have obtained transgenic plants from three cultivars of creeping bentgrass, a type of turfgrass used for golf greens. Two different vectors containing the bar gene, which confers resistance to the herbicide bialaphos, were used in the transformations. Transgenic plants were recovered from both ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-919
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  • 9
    Electronic Resource
    Electronic Resource
    Hope on the Horizon (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 944-944 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Is it possible to be a startup in today's marketplace or add value to a company while the market's down? Faced with investors still shell-shocked from failed clinical trials, the reality of long-term cash burn, and rampant speculation about the impact of healthcare reform, several biotech stock ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-944
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  • 10
    Electronic Resource
    Electronic Resource
    BST: Science and politics, Letter 2 (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 744-745 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In the June edition of Bio/Technology, Russ Hoyle describes how “FDA's BST policy wreaks havoc in the market” (12:570–571). Europeans dealing with registration of animal health products in Europe generally consider the FDA system an example for European regulators: ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0894-744b
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  • 11
    Electronic Resource
    Electronic Resource
    Debating Biotechnology (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 746-746 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On September 2,1994,16 lay people will gather at St. Anne's College, Oxford, for stage one of the first U.K. National Consensus Conference on Plant Biotechnology. The venue is ironically appropriate for an exercise marking a mutation in the relationship between science and society in Britain. In a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0894-746
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  • 12
    Electronic Resource
    Electronic Resource
    RNA–Related Tools (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 929-929 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] RNA synthesis Cruachem (Glasgow, U.K.) offers isomerically pure 2′-O-Fpmp-protected phosphoramidites. Fpmp groups are stable under ammonolytic conditions used to cleave synthetic RNA from CPG. 2′-O-Fpmp RNA is stable to alkali and endonucleases and can be purified by HPLC and stored ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0994-929
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  • 13
    Electronic Resource
    Electronic Resource
    Putting Value on Biotech Drugs (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 743-743 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Drug makers, large and small, must put cost containment and global health-care reform considerations into any equation about clinical drug development. It is no longer enough to prove that your drug is safe and effective to get it through the clinic and into the market. You also need to show that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0894-743
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  • 14
    Electronic Resource
    Electronic Resource
    Tech names (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 745-745 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: What's in a name? For biotech companies living in the illuminated goldfish bowl of the investment community, quite a lot. The term biotech may not be precise, but it does convey a particular image to the medical and investing public. Biotech company is shorthand for a research-based ...
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    URL: http://dx.doi.org/10.1038/nbt0894-745a
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  • 15
    Electronic Resource
    Electronic Resource
    Ciba-Geigy sinks up to $99 million in CoCensys (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 750-751 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] FORT COLLINS, CO—You need a scorecard to keep the players straight in the recent deal between CoCensys (Irvine, CA), Acea Pharmaceuticals (Irvine, CA), Ciba-Geigy (Basel), and Ciba Pharmaceuticals (Summit, NJ). But the long and the short of it is that CoCensys has completed its outright ...
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    URL: http://dx.doi.org/10.1038/nbt0894-750
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  • 16
    Electronic Resource
    Electronic Resource
    Second quarter sees stock continue to slide (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 754-755 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology stocks continued to decline in the second quarter of 1994, with the overall Montgomery biotechnology index down 19.5 percent for the quarter and 33 percent for the year. The first tier fell 4.3 percent in the second quarter and is down 16.1 percent for the year. The second tier, for ...
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    URL: http://dx.doi.org/10.1038/nbt0894-754
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  • 17
    Electronic Resource
    Electronic Resource
    Did FDA's Kessler tar genetic engineering? (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 760-761 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “In 1983, Brown & Williamson contracted with DNA Plant Technology to work on tobacco breeding. Much of the developmental work on Y-l took place in the laboratories, greenhouses, and fields owned by DNA Plant Technology. The high-nicotine tobacco variety, Y-l, was developed by a ...
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    URL: http://dx.doi.org/10.1038/nbt0894-760
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  • 18
    Electronic Resource
    Electronic Resource
    Is corporate and analyst hype unethical? (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 763-765 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “Investing in biotech stocks isn't for the timid. But the potential payoff may be worth it,” stated a recent headline in The Wall Street Journal. The writer, Anne Newman, pointed out that, because most biotech companies have no products or earnings, their stocks are “enormously ...
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    URL: http://dx.doi.org/10.1038/nbt0894-763
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  • 19
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    Electronic Resource
    Why Not New York? (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 776-777 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One city's attempts to get beyond complacency and into the biotech game. It began in an office in mid-town Manhattan, buoyed by a streak of promising advances. More equipment was added— personnel, too—and the space quickly filled. So when M6 Pharmaceutical's (New York, NY) CEO David ...
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    URL: http://dx.doi.org/10.1038/nbt0894-776
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  • 20
    Electronic Resource
    Electronic Resource
    The Changing Bulk Biocatalyst Market (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 789-790 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recombinant DNA techniques have changed bulk enzyme production dramaticallyIt was Steen Riisgaard, president of Novo Nordisk's (Bagsvaerd, Denmark) Bioindustrial Group (BIG), who proclaimed in 1990 that within five years virtually all industrial enzymes would be produced using recombinant DNA ...
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    URL: http://dx.doi.org/10.1038/nbt0894-789
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  • 21
    Electronic Resource
    Electronic Resource
    High-level Expression of Functional Glutamate Receptor Channels in Insect Cells (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 802-806 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have expressed glutamate-gated ion channels in Spodoptera frugiperda Sf21 insect cells using a recombinant baculovirus system. Cells infected with recombinant baculoviruses encoding the α-amino-3-hydroxy-5-methyIisoxazole-4-propionate (AMPA)-selective glutamate receptor channel subunits ...
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    URL: http://dx.doi.org/10.1038/nbt0894-802
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  • 22
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    Electronic Resource
    Questions About Genomes and Genome Projects (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 840-840 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] After many years, one of the genome projects has shed some light on the sequence organization—beyond the order of consecutive bases—of the eukaryotic genome. A recent paper in Nature (Dujon, B., et al. 1994.Nature 369: 371–378) shows that chromosome XI from the yeast Saccharomyces ...
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    URL: http://dx.doi.org/10.1038/nbt0894-840
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  • 23
    Electronic Resource
    Electronic Resource
    Can EPA handle commercial-release requests? (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 660-661 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—In an exercise that they hope will not continue to be Sisyphean, officials of the Environmental Protection Agency (EPA, Washington, DC) recently submitted revised draft rules for regulating genetically engineered microorganisms for review by the White House Office of ...
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    URL: http://dx.doi.org/10.1038/nbt0794-660b
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  • 24
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    Electronic Resource
    Europe at Bio Work: Challenges and Prospects (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 667-670 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Are Europe's education systems anticipating the needs of the growing biotech ...
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    URL: http://dx.doi.org/10.1038/nbt0794-667
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  • 25
    Electronic Resource
    Electronic Resource
    Agracetus' cotton patent draws opposition (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 659-659 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As Calgene's (Davis, CA) newly released Flavr Savr tomato now simmers in the spotlight of consumer scrutiny, a quieter controversy is bubbling in the agbiotech industry. For certain, this subject will be less public, but probably as profound in its implications, as Calgene's genetically enginereed ...
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    URL: http://dx.doi.org/10.1038/nbt0794-659
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  • 26
    Electronic Resource
    Electronic Resource
    Let's finally get the threat of virus-resistant plants straight (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 662-663 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Back in March, Keith Schneider of The New York Times wrote a story that raised consternation among researchers and regulators who are versed in the arcana of plants genetically engineered to resist viruses. As noted in this space at the time, the worst-case dangers posed to the environment by ...
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    URL: http://dx.doi.org/10.1038/nbt0794-662
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  • 27
    Electronic Resource
    Electronic Resource
    NIST will fund new DNA-diagnostics program (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 664-664 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—This spring the U.S. Department of Commerce's National Institute of Standards and Technology (NIST, Washington, DC) announced that it would begin supporting five new “focused areas of technology,” with one of these efforts involving a five-year, $145 ...
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    URL: http://dx.doi.org/10.1038/nbt0794-664
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  • 28
    Electronic Resource
    Electronic Resource
    Antibody-targeted Photolysis of Bacteria In Vivo (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 703-706 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have evaluated the efficacy of antibody-targeted photolysis to kill bacteria in vivo using specific antibacterial photosensitizer (PS) immunoconjugates. After infecting the dorsal skin in mice with Pseudomonas aeruginosa, both specific and nonspecific tin (IV) chlorin e6-monoclonal antibody ...
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    URL: http://dx.doi.org/10.1038/nbt0794-703
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  • 29
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    Biopharmaceutical R&D Success Rates and Development Times (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 674-677 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What are drugs in development worth? A snapshot of biophar-maceutical development between 1983 and 1991 shows, for instance, that compounds making it from preclinical studies to clinical phase I increase their chances of eventually reaching the market by 1.8-fold. Furthermore, the same data reveals ...
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    URL: http://dx.doi.org/10.1038/nbt0794-674
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  • 30
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    Biodegradable Polymer Scaffolds for Tissue Engineering (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 689-693 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Synthetic polymer scaffolds designed for cell transplantation were reproducibly made on a large scale and studied with respect to biocompatibility, structure and biodegradation rate. Polyglycolic acid (PGA) was extruded and oriented to form 13 μm diameter fibers with desired tenacity. Textile ...
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    URL: http://dx.doi.org/10.1038/nbt0794-689
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  • 31
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    TB: An old enemy (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 552-552 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mycobacterium tuberculosis scythed through generations in five continents without regard to the social position, wealth, or ability of its victims. Many, including young mothers, died from the disease in the 1940s and 1950s generating armies of affected relatives who, even now, still live in its ...
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    URL: http://dx.doi.org/10.1038/nbt0694-552c
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  • 32
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    Sepracor spins out BioSepra and HemaSure (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 562-562 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Sepracor (Marlborough, MA) may have dodged a bullet. This spring, it conducted two initial public offerings (IPOs), spinning off its chromatography business as BioSepra in a $21.0 million IPO in March and then spinning off its blood-separations business as HemaSure in a ...
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  • 33
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    Biotech's clinical trials and tribulations (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 564-565 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Week by week, it seems, we learn of another clinical disaster on Wall Street. In most cases, nobody died from taking the drug. But investors exposed to the stock suffer greatly. Yet investors can draw at least six lessons from the clinical trials and tribulations of emerging biotechnology ...
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  • 34
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    BIO's effective lobbying efforts (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 567-568 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—For months, the Biotechnology Industry Organization (BIO, Washington, DC) has waged a relentless lobbying campaign on drug pricing issues, remonstrating against the Clinton administration's healthcare-reform proposal. Somewhat less vocally, BIO has also sought ...
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    Clinton's malign neglect batters biotechnology (1994)
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    Nature biotechnology 12 (1994), S. 571-573 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The actions of U.S. presidential administrations have often not matched their words. Abraham Lincoln said that he would not free the slaves. Woodrow Wilson and Franklin Roosevelt swore that they would keep the U.S. out of wars. Ronald Reagan promised that he would eliminate the federal budget ...
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    Product Update (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 577-579 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Company Product Development Advanced Tissue Sciences Dermagraft Data from a multiple-dose, 50-patient trial suggests that Dermagraft, cultured human dermis, is efficacious in enhancing the healing of diabetic foot ulcers. Patients were enrolled in one of four treatment arms, with the most ...
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    Amyloid Plaque and Diabetes (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 591-594 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] New research suggests Alzheimer's disease and type II diabetes share a similar ...
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    Alliance Update (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 579-580 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Companies Agreementnt Advanced Tissue Sciences & Smith & Nephew The two will enter into a 50/50 joint venture for the worldwide development of human-tissue-engineered cartilage for orthopedic applications. The joint venture will have an initial capitalization of $20 million, with ...
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    Low-dimensional Chaos in Biological Systems (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 596-600 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] During the past five years general rules have been developed for the application of chaos theory to biology and medicine, which enable investigators to avoid the pitfalls that invalidated and trivialized many earlier results. The importance of biological chaos is that the variables governing the ...
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    Generation of Transgenic Dairy Cattle from Transgene-Analyzed and Sexed Embryos Produced In Vitro (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 606-608 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have generated a transgenic calf from in vitro produced bovine embryos which had undergone transgene analysis and sexing prior to the embryo transfer. Bovine oocytes were isolated from slaughterhouse-derived ovaries, matured and fertilized in vitro and subsequently microinjected with a ...
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    Probing Diagnostics (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 624-624 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Imagine that you have a magic reagent to which you add a little droplet of a body fluid from a patient; you wait for a moment and a glow appears in the tube holding the mixture; the glow not only tells you which pathogen is responsible for the patient's illness, it also suggests which drug to use ...
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    Health-Care Reform and Intellectual Property (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 639-640 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Clinton administration' s health-care reform legislation was introduced to Congress in July 1993, as H.R. 2624, H a bill entitled “Comprehensive Health Care and Cost Containment Act of 1993.” Discussions of the impact of that legislation have been widespread and will continue ...
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    Terminology evolution (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 433-433 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] To the editor: It is a small point, but could people writing about what David Stone calls “molecular diversity” stop calling the process of selecting random collections of combinatorially synthesized molecules “molecular evolution?”1 “Molecular evolution” means ...
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    FDA nears approval of Calgene's Flavr Savr (1994)
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    Nature biotechnology 12 (1994), S. 439-439 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—During a sometimes tumultuous three-day meeting last month, members of the Food and Drug Administration's (FDA, Rockville, MD) Food Advisory Committee (FAC) agreed with FDA officials that Calgene's (Davis, CA) Flavr Savr tomato is safe for consumers and the environment. FDA ...
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    Sacrificing current profits for future gains (1994)
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    Nature biotechnology 12 (1994), S. 444-445 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fiscal 1993 should have been a year of clinched teeth and white knuckles for executives in the agbiotech industry. After all, though the 16 agbiotech companies surveyed by Bio/Technology achieved aggregate sales of almost $410 million, they still lost a total of $153.7 million, or ...
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    MedLine update (1994)
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    Nature biotechnology 12 (1994), S. 432-433 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We wish to alert the readers of “Turning on Tumor-Fighting Cells” (Bio/Technology 11: 1117–1119, October) to a series of observations that are very relevant to the problem of lack of effectiveness of anti-tumor “killer cells” in the tumor-bearing host. ...
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    Keeping an Eye on B. thuringiensis (1994)
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    Nature biotechnology 12 (1994), S. 435-435 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “The safety record of Bacillus thuringiensis is impeccable⃜ There have been no reports of harm associated with its use for pest control⃜ It has proved totally safe for use even on food crops harvested the same day for human consumption.” (M.P. Meadows, Release of ...
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    Alliance Update (1994)
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    Nature biotechnology 12 (1994), S. 465-466 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Companies Agreement Amgen & Amcell Amgen and Amcell will commercialize products based on Amcell's cell-separation and characterization technology to treat cancer, AIDS, and other life-threatening diseases. Amgen, which has made an equity investment in Amcell, gets exclusive, worldwide rights ...
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    Biotech's New Nanotools (1994)
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    Nature biotechnology 12 (1994), S. 468-471 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Developing nanoscale approaches to biological problems is now within the reach of every ...
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    Apoptosis and Its Role in Human Disease (1994)
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    Nature biotechnology 12 (1994), S. 487-493 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In a landmark paper published over two decades ago, Kerr et al. proposed the term apoptosis “for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations”1. In the ...
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    Antibodies as Thermolabile Switches: High Temperature Triggering for the Polymerase Chain Reaction (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 506-509 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] We demonstrate the utility of antibodies to the DNA polymerase from Thermus aquaticus (TaqPol) as thermolabile inhibitors of TaqPol activity. One of the limitations of the polymerase chain reaction (PCR) is the co-amplification of non-specific products caused by TaqPol activity on low stringency ...
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    In Pursuit of Rational Drug Design (1994)
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    Nature biotechnology 12 (1994), S. 521-521 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In The Billion-Dollar Molecule: One Company's Quest for the Perfect Drug, Barry Werth tells the story of Vertex Pharmaceuticals (Cambridge, MA) through the personal histories of the people around, on, and over whom the now-public company was built. Werth centers his narrative on Joshua Boger, ...
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    Selecting Somatic Hybrid Plants Using Magnetic Protoplast Sorting (1994)
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    Nature biotechnology 12 (1994), S. 511-515 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have used a magnetic cell sorter (MACS) technique designed for animal cells to produce large samples of potato somatic hybrids. Selected biotinylated lectins are used to mediate, via streptavidin, the binding of superparamagnetic microbeads to the protoplasts of one fusion partner. The other ...
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    Fermentation & Cell Culture (1994)
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    Nature biotechnology 12 (1994), S. 529-529 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Space saver The ISF-300 series from Infers AG (Bottmingen, Switzerland) is designed so that 50-, 70-, or 100-liter fermentors can be installed in a footprint not exceeding 1.5 square meters. It features an automated sterilization facility capable of running without causing a loss of media through ...
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    Ecologically Sustainable Biotechnology (1994)
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    Nature biotechnology 12 (1994), S. 544-544 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology, as it is used now, may be clean technology—but it is not really clean enough. Better than bad is not good. Biotechnology only scratches the surface of the environmental problems that we now face. This is partly because it is only patchily applied—usually in situations in ...
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    TB is Back, But the Pipeline is Empty (1994)
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    Nature biotechnology 12 (1994), S. 327-327 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] After the discovery of streptomycin by Selman Waksman and his colleagues at New Jersey's Rutgers University in 1944, and the subsequent development of para-aminosali-cylic acid, isoniazid, and rifampin, tuberculosis' long siege finally seemed broken. In Living in the Shadow of Death, Sheila M. ...
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    Computer Products (1994)
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    Nature biotechnology 12 (1994), S. 195-195 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Easy menu Biochem Easy Menu software from Varian (Surrey, U.K.), for its Cary UV-Vis-NlR spectrophotometers, allows measurements that were previously done on chart paper to be performed on-screen. Kinetic data can be rescaled and slope calculations performed on data during a run so analyses are ...
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    Announcements (1994)
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    Nature biotechnology 12 (1994), S. 199-199 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Meetings Feb. 18–23. American Association for the Advancement of Science annual meeting. San Francisco, CA. Tel: 1 202 326 6450. Feb. 19–24. American Association for Cancer Research conference on perturbations in cell cycle control and genomic integrity. Alberta, Canada. Tel: 1 215 ...
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    Taking Aim at Sexually Transmitted Diseases (1994)
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    Nature biotechnology 12 (1994), S. 1314-1314 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Immunization has obliterated smallpox, set measles and polio melitis on the road to extinction, and curbed our fear of many other maladies. Yet not a single vaccine is commercially available to combat any one of the wide range of dangerous bacteria and viruses that can infect the human reproductive ...
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    Will Biogen and Teva challenge Berlex in MS? (1994)
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    Nature biotechnology 12 (1994), S. 1317-1318 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] FORT COLLINS, Colo.—The battle over multiple sclerosis (MS) treatments is about to be joined. Since October 1993, Berlex Laboratories (Wayne, NJ), the U.S. arm of Schering (Berlin), has had the marketplace to itself with Betaseron, a synthetic beta-interferon licensed from and manufactured by ...
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    European firms get new financing opportunities (1994)
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    Nature biotechnology 12 (1994), S. 1318-1319 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] OXFORD, U.K.—European biotech companies may soon face an embarrassment of financing opportunities. The London Stock Exchange (LSE) recently unveiled proposals to help biotech companies raise public equity. Also, a number of European financial institutions and venture capitalists have unveiled ...
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    Plant Biotechnology: The “Jury” Decides (1994)
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    Nature biotechnology 12 (1994), S. 1346-1348 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The U.K. recently tried out a Danish model of democracy and found that ordinary people can make rational judgments on ...
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    A gutsy map of the future of agbiotech (1994)
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    Nature biotechnology 12 (1994), S. 1064-1065 
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    Notes: [Auszug] It's a gutsy move when any organization forecasts things that will affect the development and commercialization of technology, even short term. But just listen to Neil Johnston of the Center for the Exploitation of Science and Technology (CEST, London): “We wanted to identify, rank, and map ...
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    NIH panel gives green light to embryo research (1994)
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    Nature biotechnology 12 (1994), S. 1067-1067 
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    Notes: [Auszug] WASHINGTON, D.C.—During the first four years of clinical tests involving human gene therapy, the technology has steadily gained acceptance. Yet more recent efforts at the National Institutes of Health (NIH, Bethesda, MD) to seek acceptance for proposals involving preclinical research on human ...
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    Antisense Expression of Polyphenol Oxidase Genes Inhibits Enzymatic Browning in Potato Tubers (1994)
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    Nature biotechnology 12 (1994), S. 1101-1105 
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    Notes: [Auszug] Spoilage caused by post–harvest enzymatic browning is a problem of considerable importance to food growers, processors and retailers. Here we show that antisense inhibition of polyphenol oxidase (PPO) gene expression abolishes discoloration after bruising of potato tubers in individual ...
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    Construction and Characterization of a Set of E. coli Strains Deficient in All Known Loci Affecting the Proteolytic Stability of Secreted Recombinant Proteins (1994)
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    Nature biotechnology 12 (1994), S. 1107-1110 
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    Notes: [Auszug] Even though secretion offers numerous advantages for the production of proteins in Escherichia coli, the expression of many heterologous proteins is severely limited by degradation in the periplasmic space. We found that mutations in rpoH, the RNA polymerase sigma factor responsible for heat shock ...
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    Large Scale, In Situ Isolation of Periplasmic IGF–I from E. coli (1994)
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    Nature biotechnology 12 (1994), S. 1113-1117 
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    Notes: [Auszug] Human insulin–like growth factor I (IGF–I) accumulates in both folded and aggregated forms in the fermentation medium and cellular periplasmic space when expressed in E. coli with an endogenous secretory signal sequence. Due to its heterogeneity in form and location, low yield of ...
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    Adverse Event Reporting (1994)
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    Nature biotechnology 12 (1994), S. 1025-1026 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] If you thought the regulatory pressures in biotechnology were already high, think again. In an industry reeling from a string of clinical failures, the pressure to monitor and demonstrate a product's safety and efficacy with impeccable data is only going to get tougher. In this regard, one of the ...
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    New Products (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 1030-1030 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Energy measurement The Stirring Intensity Measuring Device SIMD from ESD Electronic System Design (Hannover, Germany) is designed to measure the specific kinetic energy of flow fluctuations in various points of the reactor volume. One main feature is it measures the kinetic energy in multiphase ...
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    Enabling Biodiversity (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 1040-1040 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Earth Summit in Rio de Janeiro, Brazil in 1991 led to an international recognition that the preservation of biodiversity was the responsibility of every government and, ultimately, of every individual person in each nation, A fine sentiment, indeed. But the words ring hollow, especially when ...
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    Reply to “Viral recombination” (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 952-952 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mr. Hoyle replies: We owe Professor Allison an apology: The July column in question incorrectly stated that the Michigan State experiment involved cowpea plants rather than tobacco plants. However, the commentary never disputed that viral recombination had occurred, nor that researchers had ...
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    Canada knows biotech (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 953-953 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: I am writing with respect to the article by B.J. Spalding, “Canadian biotech lags behind U.S. biotech” (Bio/Technology 12:756–757, August). Even though B.J. Spalding has primarily used information from the Ernst & Young report, “Capitalizing on ...
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    Analyzing EU and U.S. agbiotech field trials (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 967-968 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] OXFORD—The European Union (EU, Brussels) has approved—since the introduction in October 1991 of its directive regulating the deliberate release of genetically modified organisms into the environment— more than 250 field trials of these organisms. Interestingly, genetically ...
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    Stem–cell–factor race heats up (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 974-974 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—The race to develop the quintessential blood-cell growth factor—if one even exists—is heating up. Such a factor, called a stem cell factor (SCF), would stimulate the replication and differentiation of stem cells, the mothers of all blood cells, as they give rise to ...
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    Surviving the '90s: Can Biotech Master Clinical Trials? (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 977-981 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Opportunities still exist for companies willing to work at making drug development work for ...
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    Still Waters Run Deep (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 983-987 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Technology improvement and greater quality awareness is changing the way water is produced for ...
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    Recombinant Reproduction (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 988-992 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The importance of gonadotrophic and related hormones in veterinary and human medicine may increase with the adoption of recombinant production ...
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    Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 994-998 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recently, there has been an increasing interest in stoichiometric analysis of metabolic flux distributions. Flux balance methods only require information about metabolic reaction stoichiometry, metabolic requirements for growth, and the measurement of a few strain–specific parameters. This ...
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    Two firms tackle cord–blood transplants (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 23-24 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] FORT COLLINS, Colo.—It was an act of desperation, one that became a topic of discussion on nearly every talk show. Marissa Ayala, a teenager with chronic myelogenous leukemia, was going to die unless she received a bone-marrow transplant. A search of the U.S. National Marrow Donor Program ...
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    NIHRAC okays nine gene–therapy proposals (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 24-25 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Last month members of the National Institutes of Health Recombinant DNA Advisory Committee (NIHRAC, Bethesda, MD) recommended approving nine gene-therapy clinical proposals, five for cancer patients, three for individuals with inherited diseases, and one for AIDS patients. In ...
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  • 81
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    Alliance Update (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 28-28 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Companies Agreement Aastrom Biosciences &Cobe The two will commercialize Aastrom's Stem Cell Expansion System, focusing on bone-marrow and stem-cell transplantation resulting from high-dose chemotherapy, with an aim of transforming these transplants from acute-care procedures into simplified ...
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    FDA derails Immunomedics' ImmuRAID–CEA (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 863-863 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Immunomedics (Morris Plains, NJ) has received a letter from the Food and Drug Administration (FDA, Rockville, MD) indicating that its product license application for ImmuRAID-CEA for colorectal cancer imaging—an application that the firm filed with the FDA in April ...
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    What the Public Thinks About Biotechnology (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 870-875 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Over the past ten years or so, more than seventy thousand people have been asked what they think of biotechnology (Table 1). The data that came out of those surveys should be enough to paint a “big picture” of the public's opinion. However, strictly speaking, it's not possible to ...
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    Mammalian Cell Expression of Single–Chain Fv (sFv) Antibody Proteins and Their C–terminal Fusions with Interleukin–2 and Other Effector Domains (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 890-897 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The production of several single–chain Fv (sFv) antibody proteins was examined by three modes of mammalian cell expression. Our primary model was the 741F8 anti–c–erbB–2 sFv, assembled as either the VH–VL or VL–VH, and expressed alone, with C–terminal ...
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    Expansion of Hematopoietic Progenitor Cell Populations in Stirred Suspension Bioreactors of Normal Human Bone Marrow Cells (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 909-914 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have investigated the potential of stirred suspension cultures to support hematopoiesis from starting innocula of normal human bone marrow cells. Initial studies showed that the short–term maintenance of both colony–forming cell (CFC) numbers and their precursors, detected as ...
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    Doubt and Certainty in Genetic Diagnosis (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 925-925 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As any clinically oriented geneticist already knows, there is often only the finest of dividing lines between “latest research,” “clinical protocols,” and “currently available techniques.” The technical and ethical issues surrounding preimplantation diagnosis are ...
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    New Products (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 930-930 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bioreactor The Tricentric bioreactors, part of the MabMAX line from Setec (Livermore, CA), use a fiber-within-fiber geometry to ensure that no cells are at a greater distance than 200 μm from oxygen and nutrients, allowing cell viabilities of over 90% throughout the bioreactor run. Write in ...
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    BST: Science and politics, Letter 1 (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 744-744 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Russ Hoyle' s article (Bio/Technology 12:570–571, June) on the U.S. Food and Drug Administration's (FDA, Rockville, MD) bovine somatotropin (BST) policy unwittingly strikes at the heart of the dilemma posed by the assessment of veterinary medicinal products and production ...
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    Proper credit (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 745-745 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The article entitled “Biotech's New Nanotools” (Bio/Technology 12: 468–471, May) provided a timely introduction to the new technologies that may result from the marriage of nanofabrication and biotechnology. It is clear that the miniaturization of diagnostic and ...
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    FDA advisory panel okays Centocor's ReoPro (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 751-753 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—In one corner of an ordinarily subdued federal auditorium, several young men in dark suits hopped up and slapped hands in “high fives,” as if they were at a sporting event and their team had unexpectedly claimed victory in overtime. Their antics came just after ...
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    Agbiotech firms increase R&D spending 43.6% (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 755-756 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The products of agbiotech should be gold plated if their caliber can be measured by their cost of research and development (R&D). U.S. agbiotech companies cranked up R&D spending an astonishing 43.6 percent in fiscal 1993, according to Bio/Technology's survey of 15 companies (Table 1). The ...
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    USDA likely to okay Asgrow's engineered squash (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 761-762 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Officials of the U.S. Department of Agriculture (USDA, Washington, D.C.) appear poised to exempt a transgenic variety of yellow crookneck squash from being further regulated. Such a decision would move Asgrow Seed's (Kalamazoo, MI) new virus-resistant line, known as ZW-20 ...
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    Establishing the utility of biotech inventions (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 766-768 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ex parte Balzarini and Ex parte Brana—two recent decisions of the U.S. Patent and Trademark Office (PTO, Arlington, VA)—illustrate why it has proven increasingly difficult to convince the PTO that a bio-technological invention satisfies the usefulness criterion of the patent laws. In ...
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    Transgenic Pea Seeds Expressing the α -Amylase Inhibitor of the Common Bean are Resistant to Bruchid Beetles (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 793-796 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Infestations of stored legume seeds by bruchid beetles, such as the cowpea weevil and the Azuki bean weevil cause substantial economic and nutritional losses of these food crops, especially in developing countries. Seeds of the common bean are resistant to these bruchids largely because of the ...
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    Overexpression of the Gene for Polyubiquitin in Yeast Confers Increased Secretion of a Human Leucocyte Protease Inhibitor (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 819-823 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have found an influence of cellular ubiquitin levels over the secretion of human leucocyte elastase inhibitor (elafin) by Saccharomyces cerevisiae. Inactivation of the UBI4 polyubiquitin gene reduced elafin secretion 3 to 4-fold. Conversely ubiquitin overexpression, by galactose induction of an ...
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    Cell-binding Peptides Conjugated to Poly(ethylene glycol) Promote Neural Cell Aggregation (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 797-801 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a method for promoting cell aggregation with bifunctional macromolecules synthesized by coupling cell-binding peptides to an inert, water-soluble polymer. The peptides Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) were conjugated through their amino termini to both ends of ...
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    Enhanced Protection Against Fungal Attack by Constitutive Co–expression of Chitinase and Glucanase Genes in Transgenic Tobacco (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 807-812 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plants respond to pathogen attack by the induction of a battery of defenses, suggesting that different protective mechanisms may have complementary roles in the overall expression of disease resistance. We have investigated possible functional interactions between two different hydrolytic enzymes, ...
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    A Risk Analysis Model for Experimental Veterinary Vaccines (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 826-827 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Assessing risk for any biomedical product is always a difficult task. Clearly defined standards are needed that both the regulatory agencies and the drug manufacturers agree to. For the vast majority of human drugs these standards are not yet available. But as a consequence of regulating new ...
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    Biotech's Role in Science Education (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 647-647 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A widely quoted set of surveys conducted by the National Science Foundation indicate that a scant 7 percent of U.S. citizens are scientifically literate—in command of a basic vocabulary and grammar of scientific terms and concepts. A subsequent poll undertaken by the National Institutes of ...
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    ABRAC brickbats (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 648-648 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Henry Miller's diatribe in the May issue Biol Technology contains errors of fact and interpretation which should not go unanswered. He says, for example, in reference to the USDA Office of Agricultural Biotechnology (OAB) and the Agricultural Biotechnology Research Advisory ...
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