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  • Macmillan Magazines Ltd.  (2,892)
  • 2015-2019
  • 1995-1999  (2,892)
  • 1980-1984
  • 1965-1969
  • 1999  (2,892)
Collection
Publisher
Years
  • 2015-2019
  • 1995-1999  (2,892)
  • 1980-1984
  • 1965-1969
Year
  • 1
    Electronic Resource
    Electronic Resource
    Dual personality of memory T cells (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 3-4 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Originally published as Nature 401, 659–660; 1999 Often, when a pathogen first infects the body, nothing happens — at least, not for several days. But when the same pathogen is encountered a second time, the response is rapid ...
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    URL: http://dx.doi.org/10.1038/402d003a0
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  • 2
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    ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 21-24 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Originally published as Nature 397, 263–266; 1999 The T-cell-specific cell-surface receptors CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances those T-cell functions that are essential for ...
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    URL: http://dx.doi.org/10.1038/402d021a0
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  • 3
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    Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 29-34 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Originally published as Nature 398, 84—90; 1999 Cbl is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface. The evolutionarily conserved ...
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    URL: http://dx.doi.org/10.1038/402d029a0
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  • 4
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    Hospital merger leaves clinical science intact (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 842-842 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir The News article by Rex Dalton about the merger between the hospitals of Stanford and the University of California, San Francisco (UCSF) is misleading (Nature 400, 300; 1999). First, it gives the impression that ...
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    URL: http://dx.doi.org/10.1038/44680
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  • 5
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    IBM promises scientists 500-fold leap in supercomputing power… (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 705-706 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Paris Biologists are hailing IBM's US$100 million project to build a ‘petaflop’ computer as likely to revolutionize our understanding of cellular biology. The computer, nicknamed ‘Blue Gene’, would be around 500 times faster than today's most ...
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    URL: http://dx.doi.org/10.1038/45312
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  • 6
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    Gaps in the Human Genome Project (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 843-845 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The adage ‘Buy now, pay later’ reflects the current operational strategy of the Human Genome Project (HGP). Thirteen per cent of the sequence is now available, and the project seems to be ahead of schedule and under budget. But the looming costs associated with gap closure in the final ...
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    URL: http://dx.doi.org/10.1038/44684
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  • 7
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    Feeling the neurobiological self (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 847-848 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The American philosopher Susan Langer, one of the most insightful commentators on emotion, proposed in her book Mind: An Essay on Human Feeling (Johns Hopkins University Press, 1988) that the most vexing question in the philosophy of the biological sciences is how something called ...
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    URL: http://dx.doi.org/10.1038/44690
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  • 8
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    Have NASA's scientists been the victims of excessive expectations? (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 711-711 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Officials at the US space agency NASA were quick to admit after the Mars Polar Lander was pronounced dead last week that the Mars programme is in trouble and needs a complete rethink.... Their hints that the next lander, scheduled for launch in 2001, may be postponed must have had engineers at the ...
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    URL: http://dx.doi.org/10.1038/45344
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  • 9
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    Dogs, telepathy and quantum mechanics (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 849-850 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Rupert Sheldrake is steadfastly incorrigible in the particular sense that he persists in error. That is the chief import of his eighth and latest book. Its main message is that animals, especially dogs, use telepathy in routine communication. The interest of this case is that the author was a ...
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    URL: http://dx.doi.org/10.1038/44696
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  • 10
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    Eccentricities of an everyday substance (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 850-851 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Linking human perceptions of water in mythology, cosmology, politics, literature and the physical and biological sciences (and pseudosciences) may seem to be an idiosyncratic objective. Yet that is just what Philip Ball, until recently a senior editor at Nature, has undertaken. With the possible ...
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    URL: http://dx.doi.org/10.1038/44698
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  • 11
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    New rhythms of our lives (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 851-852 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The moment that Neil Armstrong and Buzz Aldrin took humankind's first steps on the Moon, 30 years ago, characterizes one of the peaks of human technological progress. The event concerned everyone from an intellectual and moral point of view, but the technological impact on our everyday lives ...
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    URL: http://dx.doi.org/10.1038/44701
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  • 12
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    Know thyself genetically (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 852-853 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Genetics, I believe, will stand alongside computing and nuclear physics as one of the outstanding areas of development by which this century will be remembered. The century started precisely with the rediscovery of Mendelism and it will finish with a first draft of the complete DNA sequence of ...
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    URL: http://dx.doi.org/10.1038/44704
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  • 13
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    Darwin's evolution (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 853-854 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gilbert White, writing in 1773 in his Natural History and Antiquities of Selborne, understood why owls have unusually “soft and pliant” feathers on the tips of their wings, but he could not begin to comprehend why “some females of the brute creation … devour their ...
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    URL: http://dx.doi.org/10.1038/44707
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  • 14
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    Coelacanth à la Marseillaise (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 854-856 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In December 1938, the first living coelacanth (Latimeria chalumnae) to become known to science was accidentally caught near East London in South Africa. Coelacanths were thought to have been extinct for 70 million years — since the late Cretaceous — hence the sensational impact of ...
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    URL: http://dx.doi.org/10.1038/44710
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  • 15
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    Pogo-centricity (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 856-857 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is certainly an odd sight in the early light of an Arizona desert morning to see a number of people digging themselves into the dry soil, crawling around with their noses close to the ground, hunting for something that is invisible from even a short distance. Still, the inhabitants of Paradise ...
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    URL: http://dx.doi.org/10.1038/44713
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  • 16
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    An exobiologist's life search (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 857-858 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The astronomer Carl Sagan died of pneumonia in December 1996, following a two-year struggle with the bone-marrow disease myelodysplasia. Sagan had directed the Laboratory for Planetary Studies at Cornell University, where his research group pursued questions related to the organic chemistry of ...
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    URL: http://dx.doi.org/10.1038/44716
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  • 17
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    Innovation machine on the boil (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 859-859 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One of the most exciting recent success stories of science began in September 1986 with the appearance in the Zeitschrift für Physikof an article with the cautious title “Possible high-Tc superconductivity in the Ba–La–Cu–O system”. A few weeks ...
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    URL: http://dx.doi.org/10.1038/44721
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  • 18
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    Earth science Role reversal in geomagnetism (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 861-862 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A record of the Earth's magnetic field over geological time is preserved in rocks that are magnetized at the time of their formation. Changes in the direction and intensity of this fossil magnetism indicate that the Earth's magnetic field has repeatedly reversed its polarity. More remarkable is ...
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    URL: http://dx.doi.org/10.1038/44724
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  • 19
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    Neurobiology Exciting neurotrophins (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 862-863 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The neurotrophins are a family of secreted proteins named after their ability to regulate the survival and differentiation of nerve cells (‘neuron’ means nerve and ‘trophe’ means nutrient). But there is also evidence that neurotrophins are involved in the processes ...
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    URL: http://dx.doi.org/10.1038/44727
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  • 20
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    Mathematics Holes and hot spots (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 863-865 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the rapid development of mathematical physics between 1750 and 1825, the most important single element was the Laplace operator 〉Δ=∂ 2/∂x2+∂2/∂ y2 and its three-dimensional analogue. Even now, study of ...
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  • 21
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    Ecology Scaling, energetics and diversity (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 865-866 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There are few established laws in ecology. Most ecologists have to contend with systems of bewildering complexity, in which it is hard to separate the wood from the trees. Scientific disciplines without a good framework of rules and laws are generally considered the poor relations of their ilk, ...
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    URL: http://dx.doi.org/10.1038/44732
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  • 22
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    100 and 50 years ago (1999)
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    Nature 401 (1999), S. 865-865 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 100 YEARS AGO The long-standing question as to the admittance of women into full fellowship of scientific societies was brought before a meeting of the Lady Warwick Agricultural Association for Women on Thursday last, and the following resolution, supported by a paper by Mrs. ...
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  • 23
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    Mutation Enzymes of evolutionary change (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 401 (1999), S. 866-869 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The future is unpredictable. Survival therefore depends on the generation of a large repertoire of biological diversity — the evolutionary equivalent of buying a large number of lottery tickets. Natural selection can be compared with drawing the lottery, in that a strong selection event ...
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    URL: http://dx.doi.org/10.1038/44738
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  • 24
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    Building on failed planetary missions (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 563-563 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The likely fate of the Mars Polar Lander, coming on top of September's loss of the Mars Climate Orbiter, again calls into question the ‘better, faster, cheaper’ approach to planetary missions that the US space agency NASA has embraced under the leadership of its director, Dan Goldin ...
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    URL: http://dx.doi.org/10.1038/45012
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  • 25
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    Ultraviolet vision The colourful world of the mantis shrimp (1999)
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    Nature 401 (1999), S. 873-874 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Humans cannot see ultraviolet light, but many arthropods and vertebrates can because they have a single photo-receptor with a peak sensitivity to light at wavelengths of around 350 nanometres (ref. 1). Here we use electrophysiological methods to investigate the vision of the ...
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    US close to funding stem-cell work (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402 (1999), S. 566-566 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Washington The US National Institutes of Health (NIH) could provide funding for research on human embryonic stem cells as early as the spring if new guidelines, published by the NIH last week after widespread public consultation, are formally approved. The guidelines try to ...
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    … as Europeans lobby for reactor construction (1999)
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    Nature 402 (1999), S. 570-570 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Munich European proponents of the International Thermonuclear Experimental Reactor (ITER) have launched a campaign to win support for the construction of the fusion reactor in the run-up to key budget decisions due next year.... The first of a series of public seminars took ...
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    Seeking clarity in the debate over the safety of GM foods (1999)
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    Nature 402 (1999), S. 575-575 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir A more rigorous analysis of the debate over GM versus non-GM crops is now needed. A fundamental flaw in most arguments (for example, the debate on substantial equivalence) is the erroneous treatment of all genetically modified (GM) plants as one homogeneous group. This ...
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    Seeking a guide to the quality of web writing (1999)
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    Nature 402 (1999), S. 576-576 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir The Opinion article “Dangers of over-dependence on peer-reviewed publication” presents an interesting perspective on an important debate (Nature 401, 727; 1999). It refers to a study on the problem of ...
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    Story of an obsession (1999)
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    Nature 402 (1999), S. 581-581 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] By my count, this is the fifth time Stanley Prusiner has edited a multi-authored book on the subject of his life-long obsession: the prion, a proteinaceous–infectious particle responsible for the transmissible spongiform encephalopathies (Creutzfeldt–Jakob disease (CJD) and kuru in ...
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    Spawn of Satan? (1999)
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    Nature 402 (1999), S. 585-585 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Egg donation has begun to bias the new and controversial Raswani Social Intelligence scale and the more traditional Stanford–Binet IQ test. Nationwide testing has been prompted by what some educators are calling an exponential change in the behaviour of kindergarten children. “We ...
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    Volcanology Magma fragmentation in eruptions (1999)
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    Nature 402 (1999), S. 589-591 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Some volcanic eruptions are gentle and effusive, and even (as on Hawaii) support a tourist trade. Others, such as the eruptions of Mount St Helens in 1980 and of Mount Pinatubo in 1991, are violent and terrifying, causing severe damage, loss of life and even temporary climate change. The difference ...
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    Nuclear physics Taking serious risks seriously (1999)
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    Nature 402 (1999), S. 596-597 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Risk management is not a new idea: miners once used caged canaries as methane detectors. But modern technologies have made worldwide catastrophes imaginable — disasters so dreadful that we demand proof-in-principle that they cannot happen. Failures at nuclear reactors and chemical plants ...
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    Astrophysics Chaotic planet formation (1999)
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    Nature 402 (1999), S. 599-600 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our understanding of how planets formed around the Sun is far from complete, and is increasingly challenged by new discoveries of unusual planetary-mass companions around other stars. The idea that chaotic dynamics — or extreme sensitivity to initial conditions — plays a large role in ...
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    Keeping time (1999)
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    Nature 402.1999, 6761supp, C17-, (1 S.) 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] How finely can time be measured? The answer might define our capacity to conduct precise tests of general relativity, as demonstrated already in the observed increase in clock rate with distance from the Earth's surface, or the measurement of relativistic effects in binary pulsar ...
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    Flashes in femtoseconds (1999)
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    Nature 402.1999, 6761supp, C30-, (1 S.) 
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    Notes: [Auszug] For the molecule, time ticks in picoseconds, or even femtoseconds — respectively 10−12 and 10−15 s. On such timescales, a molecule tumbles through space, an atom vibrates back and forth in a crystal, a chemical bond is forged or broken. ...
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    The future of evolutionary developmental biology (1999)
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    Nature 402.1999, 6761supp, C41-, (4 S.) 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Evolutionary biology and developmental biology, or embryology, have had a stormy relationship over the past hundred years. At the end of the nineteenth century and the start of the twentieth, they were inseparable; comparisons of the embryonic development of different species were used as ...
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    From molecular to modular cell biology (1999)
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    Nature 402.1999, 6761supp, C47-, (6 S.) 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although living systems obey the laws of physics and chemistry, the notion of function or purpose differentiates biology from other natural sciences. Organisms exist to reproduce, whereas, outside religious belief, rocks and stars have no purpose. Selection for function has produced the living ...
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    Transitions still to be made (1999)
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    Nature 402.1999, 6761supp, C73-, (4 S.) 
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    Notes: [Auszug] Physics in the twentieth century will probably be remembered for quantum mechanics, relativity and the Standard Model of particle physics. Yet the conceptual framework within which most physicists operate is not necessarily defined by the first of these and makes reference only rarely to the ...
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    Human chromosome 22 and the virtues of collaboration (1999)
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    Nature 402 (1999), S. 445-445 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Geneticists and many others have cause to celebrate this week. The consortium behind the publicly funded international Human Genome Project has just put the one-billionth base pair of sequence into the public databases, and today is publishing the first sequence of a human chromosome, number 22 ...
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    Dangers of over-dependence on peer-reviewed publication (1999)
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    Nature 401 (1999), S. 387-387 
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    Notes: [Auszug] Like it or not, the days of ink on paper are numbered — and the number is smaller than many people imagine. This may sound regrettable: no one can comfortably read even a laptop computer in bed, whereas Nature's Millennium Essays, for example, are just the sort of erudite relief that ...
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    Venter's Drosophila ‘success’ set to boost human genome efforts (1999)
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    Nature 401 (1999), S. 729-730 
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    Notes: [Auszug] Paris Maverick, dreamer or visionary? The jury is still out on Craig Venter, head of Celera Genomics Systems, whose ambition is to sequence and piece together the entire human genome by 2001 using a controversial ‘whole-genome shotgun’ strategy.... But Venter, who ...
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    Wellcome funds cancer database (1999)
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    Nature 401 (1999), S. 729-729 
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    Notes: [Auszug] London Britain's Wellcome Trust is to provide up to £10 million ($16.5 million) over the next five years to detect the genes that are mutated in human cancers and release the information to a public database.... The project, to be based at the Sanger Centre near ...
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    Journal under attack over controversial paper on GM food (1999)
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    Nature 401 (1999), S. 731-731 
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    Notes: [Auszug] London The medical journal The Lancet has been criticized by Britain's Royal Society for publishing a paper on genetically modified (GM) potatoes by controversial author Arpad Pusztai. The study has been a source of continuing furore in Britain following a statement by ...
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    Japanese guidelines specify the terms of gene patents (1999)
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    Nature 401 (1999), S. 731-731 
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    Notes: [Auszug] Tokyo The Japanese Patent Office (JPO) has released guidelines on human gene patents. These outline its view of the patentability of expressed sequenced tags (ESTs), single nucleotide polymorphisms (SNPs) and full-length complementary DNA (cDNA) clones. Although the office ...
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    Research chair bonanza in Canada (1999)
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    Nature 401 (1999), S. 731-732 
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    Notes: [Auszug] Montreal Canadian prime minister Jean Chrétien has announced that the federal government is to fund 2,000 new research chairs at universities, 1,200 of them over the next three years.... “This is incredibly exciting,” commented Robert Prichard, president of ...
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    US university fears allayed over access to research data (1999)
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    Nature 401 (1999), S. 732-732 
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    Notes: [Auszug] Washington Final regulations covering access to university researchers' data under the Freedom of Information Act were published in Washington last week. They seem to have gone some way towards satisfying both sides in a bitter dispute over how far such access rights should ...
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    PNAS joins peer-reviewed PubMed Central (1999)
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    Nature 401 (1999), S. 733-733 
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    Notes: [Auszug] Washington The Proceedings of the National Academy of Sciences (PNAS) will appear on PubMed Central, the US National Institutes of Health's (NIH) new research archive, one month after the publication of the journal. But the academy's governing council will only allow this if ...
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    Funding changes aim to reform German universities (1999)
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    Nature 401 (1999), S. 733-733 
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    Notes: [Auszug] Munich Germany's Bund-Länder Kommission (BLK), which negotiates joint financing of education and research between federal and state governments, will discuss next week the implementation of a new special fund for financing reforms in universities and other ...
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    French students continue to turn away from science (1999)
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    Nature 401 (1999), S. 732-732 
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    Notes: [Auszug] Paris The number of students studying science in French universities and high schools has fallen for the fourth year in a row, according to figures released last week by the ministry for national education, research and technology. Between 1995 and 1999, the number of ...
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    Genetic variations can point the way to disease genes (1999)
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    Nature 401 (1999), S. 734-734 
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    Notes: [Auszug] London Researchers have shown for the first time that the search for human genes can be substantially narrowed using maps of small variations in the genome, according to a presentation this week at the American Society of Human Genetics (ASHG). They also claim that the density ...
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    Induction and regulation of the IgE response (1999)
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    Nature 402 (1999), S. 18-23 
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    Notes: [Auszug] Immunoglobulin E (IgE) is believed to be one of the major mediators of immediate hypersensitivity reactions that underlie atopic conditions such as urticaria, seasonal allergy, asthma and anaphylaxis. Factors that control IgE production are therefore essential to the pathogenesis of these ...
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    Allergy and asthma: Glossary (1999)
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    Nature 402 (1999), S. 39-39 
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    Notes: [Auszug] Adjuvant. Any agent that augments or facilitates a desired immune outcome. Immune adjuvants amplify immune responses to discrete antigens and often determine the direction (Th1 or Th2) of the response. Airway or bronchial hyperresponsiveness. Characteristic physiological ...
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    News in brief (1999)
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    Nature 401 (1999), S. 736-737 
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    Notes: [Auszug] US guidelines widen the net on scientific misconduct London President Bill Clinton's administration last week proposed new guidelines for investigating scientific misconduct involving government-funded research. The long-awaited guidelines, issued by ...
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    US Senate ignores scientific advice in failing to ratify test ban treaty (1999)
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    Nature 401 (1999), S. 735-735 
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    Notes: [Auszug] Washington When the US Senate announced on 1 October that it would vote on the Comprehensive Test Ban Treaty within 12 days, senior researchers with a stake in the treaty wasted little time.... Frank Von Hippel, professor of public and international affairs at Princeton ...
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    Millions at risk as big cities grow apace in earthquake zones (1999)
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    Nature 401 (1999), S. 738-738 
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    Notes: [Auszug] Sir The recent earthquakes in Taiwan, Turkey and Greece are a reminder that the world's urban population is increasingly vulnerable to earthquakes. About one-third of the world's supercities — those with populations of more than two million — are located near ...
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    Where are the high-tech entrepreneurs? (1999)
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    Nature 401 (1999), S. 738-738 
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    Notes: [Auszug] Sir Craig Pickering argues that a culture of venture capitalism must be created in Europe (Nature 401, 209–210; 1999). I do not believe that lack of government support or venture capital is the reason for the ...
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    The birth of Big Biology (1999)
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    Nature 401 (1999), S. 738-738 
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    Notes: [Auszug] Sir Your editorial “Big Science comes of age” suggests that, in my writings of 40 years ago, I neglected Big Biology. On the contrary, I argued that “We are entering an age of biomedical science and biomedical technology that could rival in magnitude and ...
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    Corot would put more planets in the picture (1999)
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    Nature 401 (1999), S. 738-738 
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    Notes: [Auszug] Sir Declan Butler reports on the difficulties the French satellite Corot is facing owing to budgetary reductions (Nature 401, 202; 1999). This report is mainly correct, but I must respond to comments made by David Hughes and cited ...
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    What is a wave? (1999)
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    Nature 401 (1999), S. 739-740 
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    Notes: [Auszug] Ask your colleagues and students to define a wave, and you may be surprised at the answers you get. Even wave professionals are prone to confusion and vagueness when confronted with such an apparently simple question. Students often begin circularly: “a wave is a solution to the wave ...
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    Giants' footprints in the greenhouse (1999)
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    Nature 401 (1999), S. 741-742 
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    Notes: [Auszug] It is a rare opportunity for a scientist to be offered a chance to review the work of historians; more often, it is the other way around. In this case, two professors of history have written about the development of our scientific understanding of global warming. My interest is in their choices ...
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    Confessions of a modern roué (1999)
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    Nature 401 (1999), S. 743-744 
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    Notes: [Auszug] Gunter Siegmund Stensch was born into a prosperous Jewish family in Berlin during the turbulent days of the Weimar Republic. In later life he cast off the heroic Wagnerian encumbrance of names his parents had wished on him, and as Gunther Stent became a phage geneticist of note and latterly a ...
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    Planting the evidence (1999)
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    Nature 401 (1999), S. 742-743 
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    Notes: [Auszug] Many scientific scandals result from incompetence, poor methodology or the unexpected behaviour of equipment, but why might a researcher deliberately falsify results? As the pressure to produce results and publish has given just about every academic a motive, perhaps cases from the past might ...
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    New in paperback (1999)
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    Nature 401 (1999), S. 743-743 
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    Notes: [Auszug] “Christopher McGowan clearly loves animals and their adaptations, and this is a thoroughly enjoyable popular account, written for the reader who likes something meatier than a TV wildlife spectacular… McGowan is at his best with the sheer physicality of hunting: the magnificence of ...
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    Science in culture (1999)
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    Nature 401 (1999), S. 744-744 
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    Notes: [Auszug] Animal arts ... As soon as ancient philosophers attempted to differentiate human from animal intelligence, a few celebrated cases of ‘animal geometers’ attracted avid attention. The webs of spiders, the honeycombs of bees and the spiral shells of molluscs are the classic ...
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    Spark ignites physicists (1999)
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    Nature 401 (1999), S. 745-745 
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    Notes: [Auszug] Physics textbooks tell us that Heinrich Hertz discovered electromagnetic waves in 1888. In so doing, Hertz proved experimentally that it was James Clerk Maxwell's theory of electromagnetic radiation, and not the idea of electrical action at a distance, defended by continental physicists such as ...
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    Life on the road (1999)
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    Nature 401 (1999), S. 747-747 
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    Notes: [Auszug] To form the connections of the nervous system, axons must find their targets by setting out on a journey that may be long and complicated. How do they select the right path? What happens to those that stray off in the wrong direction? Intermediate targets are known to act as signposts along the ...
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    100 and 50 years ago (1999)
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    Nature 401 (1999), S. 748-748 
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    Notes: [Auszug] 100 YEARS AGO A bicycle ride will be none the less enjoyable if you train yourself, not merely to travel far, but to take an interest in the sights and scenes through which you pass. For the sake of example, let me remind you that no country is so rich as England in the ...
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    Protein crystallography Frozen in time (1999)
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    Nature 401 (1999), S. 748-748 
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    Notes: [Auszug] Biochemical reactions are extremely rapid, but the methods for imaging the enzymes that catalyse them can take hours. To get round this problem, structures can be determined at temperatures around 100 K, literally freezing an enzyme's movements and allowing the intermediates in its reaction cycle ...
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    Chemical physics Molecules are cool (1999)
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    Nature 401 (1999), S. 749-751 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Under ordinary conditions, atoms and molecules of a gas zigzag in all directions and have a wide distribution of speeds related to temperature. At room temperature, for instance, gaseous atoms or molecules are most likely to move at the speed of rifle bullets. Such restlessness puts a limit on the ...
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    Pharmacology Towards better benzodiazepines (1999)
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    Nature 401 (1999), S. 751-752 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sleeplessness and anxiety afflict us all — sometimes to the point of breakdown. The usual treatment is drugs of the benzodiazepine family, such as diazepam (Valium), which have helped millions of patients since they were introduced in the late 1950s. Benzodiazepines induce relaxation, but ...
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    How head-hunters track down the winners for science's top jobs (1999)
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    Nature 401 (1999), S. 407-409 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...Business is booming for head-hunters. More and more directors of industrial research and development, heads of research organizations and university vice-chancellors are being selected through executive search agencies — companies that typically charge £35,000 (US$56,200) to ...
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    Immunology Toll gates for pathogen selection (1999)
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    Nature 401 (1999), S. 755-756 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] All species need an immediate, systemic reply to the microbial pathogens in their environment. This reply — known as the innate immune response — is characterized by the de novo production of mediators that either kill the pathogen directly or induce phagocytic cells to ingest and kill ...
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    Earth science Mercurial vents (1999)
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    Nature 401 (1999), S. 755-756 
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    Notes: [Auszug] On the land, many hot springs are enriched in trace metals, and have laid down economically important deposits of gold, silver and mercury. Now, Peter Stoffers from Kiel University and co-workers from Canada and New Zealand have discovered the first mercury-producing hot springs under the sea, in ...
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    Fluid dynamics Order in chaos (1999)
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    Nature 401 (1999), S. 756-758 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Vast quantities of fluid are mixed every day, both naturally and for industrial purposes, and one might think that mixing processes are fully understood scientifically. That is far from the case. New insights are continually emerging, as exemplified by the paper by Rothstein, Henry and Gollub on ...
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    Iranian visit fosters links with US (1999)
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    Nature 401 (1999), S. 199-199 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] San Diego A group of Iranian scientific leaders last week visited the US National Academy of Sciences in Washington DC in the first scientific exchange since the two nations broke diplomatic relations 20 years ago. After the visit, academy officials said they plan to send a ...
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    Kansas evolution ban under attack (1999)
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    Nature 401 (1999), S. 200-200 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Washington Two professional biology organizations have added their voices to criticisms of the decision by the Kansas Board of Education to eliminate the teaching of evolution from the school science curriculum (see Nature 400, 701; ...
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    HIV See a pocket, block it (1999)
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    Nature 401 (1999), S. 759-759 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although drugs such as protease and reverse-transcriptase inhibitors have had a huge effect on treating AIDS in the developed world, they are not without their problems: they do not eradicate HIV-1 from infected people; long-term side effects have been observed; and drug-resistant variants of HIV-1 ...
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    France set to cut search for small extrasolar planets (1999)
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    Nature 401 (1999), S. 202-202 
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    Notes: [Auszug] Paris Only a few years after the discovery of giant, extrasolar planets, a proposed French mission to extend the search to smaller planets in ‘habitable’ orbits is at risk of being axed. The project (see Nature 400, ...
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    erratum (1999)
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    Nature 401 (1999), S. 760-760 
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    Notes: [Auszug] erratum Due to an editorial oversight, the picture accompanying the article “Neurobiology: Cognition by a mini brain” (Nature 400, 718–719; 1999), did not carry the correct attribution. It should have been credited to ...
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    Daedalus Setting and upsetting (1999)
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    Nature 401 (1999), S. 760-760 
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    Notes: [Auszug] Last week Daedalus presented his ‘Wet Cement’, a hygroscopic concrete which set but never dried out. A building made from it could creep rather than crack while settling into the soil. He is now taking the idea to extremes. His new, even more advanced cement does not merely creep under ...
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    Hox genes and the making of sphincters (1999)
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    Nature 401 (1999), S. 761-762 
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    Notes: [Auszug] As well as their shared role in the anteroposterior patterning of vertebrates, particular Hox gene com-plexes have evolved specific functions. For example, four consecutive genes of the HoxD cluster contribute to making proper digits. Functional studies of such traits are difficult because ...
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    Evolution Dicyemids are higher animals (1999)
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    Nature 401 (1999), S. 762-762 
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    Notes: [Auszug] Dicyemids, which are microscopic parasites of squids and octopuses, have among the simplest body plans of all multicellular animals. They lack body cavities and almost all the organs that characterize animals, such as a gut or nervous system, and their development proceeds without germ layers ...
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    Insect behaviour Male beetles attracted by females mounting (1999)
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    Nature 401 (1999), S. 762-763 
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    Notes: [Auszug] Intrasexual mounting is performed by males and females of many taxa, and female–female mounting occurs in insects, lizards, birds and mammals. Although the adoption by females of other male-like characters, such as mimicry of male colour patterns, is known to be advantageous, the benefits ...
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    Environmental toxins Exposure to bisphenol A advances puberty (1999)
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    Nature 401 (1999), S. 763-764 
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    Notes: [Auszug] Plastics and pesticides are examples of products that contain oestrogenic endocrine-disrupting chemicals, or EEDCs, which can interfere with mammalian development by mimicking the action of the sex hormone oestradiol. For instance, the exposure of developing rodents to high doses of EEDCs ...
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    Perceiving confluent disciplines (1999)
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    Nature 401 (1999), S. 213-214 
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    Notes: [Auszug] This is an impressive, well-produced and easy-to-read textbook of visual science, even though it is quite technical in places. It is enlivened with historical asides and has underlying philosophical themes, although its main thrust is to present the current experimental understanding of how we ...
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    Prosaic poetics (1999)
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    Nature 401 (1999), S. 214-214 
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    Notes: [Auszug] In giving his book the title The Poetics of Natural History, Christoph Irmscher's aim seems to be to intrigue and impress literary historians with the writings of early American naturalists. He claims that the book is about the daydreams of American naturalists from 1730 to 1868. These ...
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    Cracking anaerobic bacteria (1999)
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    Nature 401 (1999), S. 217-218 
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    Notes: [Auszug] At any one moment, some ten billion tons of particulate organic matter is sinking down through the world's oceans. This organic matter stimulates microbial activity to such an extent that only a small proportion of it — less than 0.5% — survives the long descent through the water column ...
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    Microbiology Salmonella strikes a balance (1999)
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    Nature 401 (1999), S. 218-219 
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    Notes: [Auszug] In landmark studies done more than 30 years ago, Takeuchi described the invasion of intestinal cells by Salmonella at an ultrastructural level. His careful observations detailed not only the dramatic alterations in a cell's architecture that accompany bacterial entry, but also the equally striking ...
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    Cosmology Universal peekaboo (1999)
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    Nature 401 (1999), S. 219-221 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Near the end of the millennium, new observations and analyses are suggesting answers to some of the most profound and ageless questions. What is the extent of the Universe? How old is it? What is its shape? What is its ultimate fate? The answers to these questions have come from philosophers and ...
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    Atmospheric chemistry Clouds and climate (1999)
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    Nature 401 (1999), S. 223-225 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Soapy components of air pollutants lower the surface tension of tiny, wetted, aerosol particles. This could make the particles more likely to turn into cloud drops, through condensation of water vapour on their surface, and lead to a larger number of cloud drops of smaller size. The upshot — ...
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    Biophysics Singular take on molecules (1999)
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    Nature 401 (1999), S. 225-226 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] What is life? At its most basic, it is the subtle interplay of large numbers of proteins that interact through enzymatic reactions and complex signalling pathways. The description of this molecular machinery becomes more detailed by the day, yet our understanding of biological processes at the most ...
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    Developmental biology Antagonists on the left flank (1999)
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    Nature 401 (1999), S. 222-223 
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    Notes: [Auszug] The early development of vertebrate embryos is, essentially, a sequence of switches in cell fate. These switches are triggered by signals that cells receive from their neighbours. We used to think of these signals as operating directly and in isolation. Then, some signals were discovered to be ...
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    Food contamination by PCBs and dioxins (1999)
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    Nature 401 (1999), S. 231-232 
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    Notes: [Auszug] In February 1999, a poisoning episode broke out in several poultry farms in Belgium. The Belgian authorities took immediate safeguards to protect public health and implemented a large-scale food-monitoring programme. Here we analyse the scale of the contamination and assess the likelihood of ...
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    Reproductive biology Pheromones and regulation of ovulation (1999)
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    Nature 401 (1999), S. 232-232 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There is controversy surrounding the issue of whether there is menstrual synchrony in women who live together, particularly in the case of the coupled-oscillator model developed to explain similar data from rats. Stern and McClintock have proposed that the rat model applies to women, with the ...
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    reply: Reproductive biology Pheromones and regulation of ovulation (1999)
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    Nature 401 (1999), S. 232-233 
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    Notes: [Auszug] McClintock replies We first reported menstrual synchrony almost three decades ago, and it has since been verified repeatedly. But synchrony does not always occur, and the circumstances in which it does not occur tell us a great deal about the social and physical conditions ...
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    Touching a nerve (1999)
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    Nature 401 (1999), S. 827-828 
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    Notes: [Auszug] Neurotransmissions newsletter Sigma RBIwww.sigma-aldrich.comReader Service No. 100 Latest edition of this free quarterly Neurotransmissions Vol. 15, No. 2, published by Sigma ...
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    Financial flexibility the key to Germany's scientific prosperity (1999)
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    Nature 401 (1999), S. 623-623 
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    Notes: [Auszug] A glance across Central and Eastern Europe quickly reveals how well east German science has done since the Berlin Wall fell ten years ago. Without the generous subsidies from the German federal government after reunification and the tough imposition of Western standards of research, east German ...
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    Caution: traditional knowledge (1999)
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    Nature 401 (1999), S. 623-623 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] What makes knowledge ‘scientific’, and thus distinguishable from other forms? This question has a relevance well beyond the philosophical, with the scientific nature of data having an increasing significance in issues ranging from the reproducibility of discoveries for which patents are ...
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    Medicine Nobel goes to pioneer of protein guidance mechanisms (1999)
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    Nature 401 (1999), S. 625-625 
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    Notes: [Auszug] London This year's Nobel Prize for Physiology or Medicine has been awarded to Günter Blobel, of the Rockefeller University in New York, for his discovery that proteins are manufactured with in-built address labels that guide them to their destinations in the cell.... ...
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