ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Other Sources  (71)
  • Articles (OceanRep)  (71)
  • MDPI  (61)
  • American Meteorological Society
  • Springer Nature
  • 2015-2019  (71)
  • 1
    facet.materialart.
    Unknown
    Unusual marine unicellular symbiosis with the nitrogen-fixing cyanobacterium UCYN-A (2016)
    Springer Nature
    In:  Nature Microbiology, 2 (16214).
    Details
    Publication Date: 2020-06-24
    Description: Nitrogen fixation — the reduction of dinitrogen (N2) gas to biologically available nitrogen (N) — is an important source of N for terrestrial and aquatic ecosystems. In terrestrial environments, N2-fixing symbioses involve multicellular plants, but in the marine environment these symbioses occur with unicellular planktonic algae. An unusual symbiosis between an uncultivated unicellular cyanobacterium (UCYN-A) and a haptophyte picoplankton alga was recently discovered in oligotrophic oceans. UCYN-A has a highly reduced genome, and exchanges fixed N for fixed carbon with its host. This symbiosis bears some resemblance to symbioses found in freshwater ecosystems. UCYN-A shares many core genes with the 'spheroid bodies' of Epithemia turgida and the endosymbionts of the amoeba Paulinella chromatophora. UCYN-A is widely distributed, and has diversified into a number of sublineages that could be ecotypes. Many questions remain regarding the physical and genetic mechanisms of the association, but UCYN-A is an intriguing model for contemplating the evolution of N2-fixing organelles.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 2
    facet.materialart.
    Unknown
    Bifurcatriol, a New Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata (2017)
    MDPI
    In:  Marine Drugs, 15 (8). Art.Nr. 245.
    Details
    Publication Date: 2020-02-06
    Description: Linear diterpenes that are commonly found in brown algae are of high chemotaxonomic and ecological importance. This study reports bifurcatriol (1), a new linear diterpene featuring two stereogenic centers isolated from the Irish brown alga Bifurcariabifurcata. The gross structure of this new natural product was elucidated based on its spectroscopic data (IR, 1D and 2D-NMR, HRMS). Its absolute configuration was identified by experimental and computational vibrational circular dichroism (VCD) spectroscopy, combined with the calculation of 13C-NMR chemical shielding constants. Bifurcatriol (1) was tested for in vitro antiprotozoal activity towards a small panel of parasites (Plasmodium falciparum, Trypanosoma brucei rhodesiense, T. cruzi, and Leishmania donovani) and cytotoxicity against mammalian primary cells. The highest activity was exerted against the malaria parasite P. falciparum (IC50 value 0.65 μg/mL) with low cytotoxicity (IC50 value 56.6 μg/mL). To our knowledge, this is the first successful application of VCD and DP4 probability analysis of the calculated 13C-NMR chemical shifts for the simultaneous assignment of the absolute configuration of multiple stereogenic centers in a long-chain acyclic natural product.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 3
    facet.materialart.
    Unknown
    Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus (2018)
    MDPI
    In:  Antibiotics, 7 (3). Art.Nr. 53.
    Details
    Publication Date: 2021-02-08
    Description: The structural repertoire of bioactive naphthacene quinones is expanded by engineering Streptomyces albus to express the lysolipin minimal polyketide synthase II (PKS II) genes from Streptomyces tendae Tü 4042 (llpD-F) with the corresponding cyclase genes llpCI-CIII. Fermentation of the recombinant strain revealed the two new polyaromatic tridecaketides lysoquinone-TH1 (7, identified) and TH2 (8, postulated structure) as engineered congeners of the dodecaketide lysolipin (1). The chemical structure of 7, a benzo[a]naphthacene-8,13-dione, was elucidated by NMR and HR-MS and confirmed by feeding experiments with [1,2-13C2]-labeled acetate. Lysoquinone-TH1 (7) is a pentangular polyphenol and one example of such rare extended polyaromatic systems of the benz[a]napthacene quinone type produced by the expression of a minimal PKS II in combination with cyclases in an artificial system. While the natural product lysolipin (1) has antimicrobial activity in nM-range, lysoquinone-TH1 (7) showed only minor potency as inhibitor of Gram-positive microorganisms. The bioactivity profiling of lysoquinone-TH1 (7) revealed inhibitory activity towards phosphodiesterase 4 (PDE4), an important target for the treatment in human health like asthma or chronic obstructive pulmonary disease (COPD). These results underline the availability of pentangular polyphenolic structural skeletons from biosynthetic engineering in the search of new chemical entities in drug discovery
    Type: Article , PeerReviewed
    Format: text
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 4
    facet.materialart.
    Unknown
    Phase Equilibria of the CH4-CO2 Binary and the CH4-CO2-H2O Ternary Mixtures in the Presence of a CO2-Rich Liquid Phase (2017)
    MDPI
    In:  Energies, 10 (12, Art. No. 2034).
    Details
    Publication Date: 2020-02-06
    Description: The knowledge of the phase behavior of carbon dioxide (CO2)-rich mixtures is a key factor to understand the chemistry and migration of natural volcanic CO2 seeps in the marine environment, as well as to develop engineering processes for CO2 sequestration coupled to methane (CH4) production from gas hydrate deposits. In both cases, it is important to gain insights into the interactions of the CO2-rich phase—liquid or gas—with the aqueous medium (H2O) in the pore space below the seafloor or in the ocean. Thus, the CH4-CO2 binary and CH4-CO2-H2O ternary mixtures were investigated at relevant pressure and temperature conditions. The solubility of CH4 in liquid CO2 (vapor-liquid equilibrium) was determined in laboratory experiments and then modelled with the Soave–Redlich–Kwong equation of state (EoS) consisting of an optimized binary interaction parameter kij(CH4-CO2) = 1.32 × 10−3 × T − 0.251 describing the non-ideality of the mixture. The hydrate-liquid-liquid equilibrium (HLLE) was measured in addition to the composition of the CO2-rich fluid phase in the presence of H2O. In contrast to the behavior in the presence of vapor, gas hydrates become more stable when increasing the CH4 content, and the relative proportion of CH4 to CO2 decreases in the CO2-rich phase after gas hydrate formation.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 5
    facet.materialart.
    Unknown
    Nitric Oxide Isotopic Analyzer Based on a Compact Dual-Modulation Faraday Rotation Spectrometer (2015)
    MDPI
    In:  Sensors, 15 (10). pp. 25992-26008.
    Details
    Publication Date: 2018-02-05
    Description: We have developed a transportable spectroscopic nitrogen isotopic analyzer. The spectrometer is based on dual-modulation Faraday rotation spectroscopy of nitric oxide isotopologues with near shot-noise limited performance and baseline-free operation. Noise analysis indicates minor isotope (15NO) detection sensitivity of 0.36 ppbv·Hz−1/2, corresponding to noise-equivalent Faraday rotation angle (NEA) of 1.31 × 10−8 rad·Hz−1/2 and noise-equivalent absorbance (αL)min of 6.27 × 10−8 Hz−1/2. White-noise limited performance at 2.8× the shot-noise limit is observed up to ~1000 s, allowing reliable calibration and sample measurement within the drift-free interval of the spectrometer. Integration with wet-chemistry based on acidic vanadium(III) enables conversion of aqueous nitrate/nitrite samples to gaseous NO for total nitrogen isotope analysis. Isotopic ratiometry is accomplished via time-multiplexed measurements of two NO isotope transitions. For 5 μmol potassium nitrate samples, the instrument consistently yields ratiometric precision below 0.3‰, thus demonstrating potential as an in situ diagnostic tool for environmental nitrogen cycle studies.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 6
    facet.materialart.
    Unknown
    Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B (2017)
    MDPI
    In:  Marine Drugs, 15 (6). p. 191.
    Details
    Publication Date: 2020-02-06
    Description: In the frame of studies on secondary metabolites produced by fungi from deep-sea environments we have investigated inhibitors of enzymes playing key roles in signaling cascades of biochemical pathways relevant for the treatment of diseases. Here we report on a new inhibitor of the human protein tyrosine phosphatase 1B (PTP1B), a target in the signaling pathway of insulin. A new asperentin analog is produced by an Aspergillus sydowii strain isolated from the sediment of the deep Mediterranean Sea. Asperentin B (1) contains an additional phenolic hydroxy function at C-6 and exhibits an IC50 value against PTP1B of 2 μM in vitro, which is six times stronger than the positive control, suramin. Interestingly, asperentin (2) did not show any inhibition of this enzymatic activity. Asperentin B (1) is discussed as possible therapeutic agents for type 2 diabetes and sleeping sickness.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 7
    facet.materialart.
    Unknown
    What genomic data can reveal about eco-evolutionary dynamics (2017)
    Springer Nature
    In:  Nature Ecology & Evolution, 2 . pp. 9-15.
    Details
    Publication Date: 2020-06-25
    Description: Recognition that evolution operates on the same timescale as ecological processes has motivated growing interest in eco-evolutionary dynamics. Nonetheless, generating sufficient data to test predictions about eco-evolutionary dynamics has proved challenging, particularly in natural contexts. Here we argue that genomic data can be integrated into the study of eco-evolutionary dynamics in ways that deepen our understanding of the interplay between ecology and evolution. Specifically, we outline five major questions in the study of eco-evolutionary dynamics for which genomic data may provide answers. Although genomic data alone will not be sufficient to resolve these challenges, integrating genomic data can provide a more mechanistic understanding of the causes of phenotypic change, help elucidate the mechanisms driving eco-evolutionary dynamics, and lead to more accurate evolutionary predictions of eco-evolutionary dynamics in nature.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 8
    facet.materialart.
    Unknown
    Open discussion of negative emissions is urgently needed (2017)
    Springer Nature
    In:  Nature Energy, 2 (12). pp. 902-904.
    Details
    Publication Date: 2020-06-25
    Description: Although nearly all 2 °C scenarios use negative CO2 emission technologies, only relatively small investments are being made in them, and concerns are being raised regarding their large-scale use. If no explicit policy decisions are taken soon, however, their use will simply be forced on us to meet the Paris climate targets.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 9
    facet.materialart.
    Unknown
    Isolation of Petrocidin A, a New Cytotoxic Cyclic Dipeptide from the Marine Sponge-Derived Bacterium Streptomyces sp. SBT348 (2017)
    MDPI
    In:  Marine Drugs, 15 (12, Article Number 383).
    Details
    Publication Date: 2020-02-06
    Description: A new cyclic dipeptide, petrocidin A (1), along with three known compounds—2,3dihydroxybenzoic acid (2), 2,3-dihydroxybenzamide (3), and maltol (4)—were isolated from the solid culture of Streptomyces sp. SBT348. The strain Streptomyces sp. SBT348 had been prioritized in a strain collection of 64 sponge-associated actinomycetes based on its distinct metabolomic profile using liquid chromatography/high-resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonance (NMR). The absolute configuration of all α-amino acids was determined by HPLC analysis after derivatization with Marfey’s reagent and comparison with commercially available reference amino acids. Structure elucidation was pursued in the presented study by mass spectrometry and NMR spectral data. Petrocidin A (1) and 2,3-dihydroxybenzamide (3) exhibited significant cytotoxicity towards the human promyelocytic HL-60 and the human colon adenocarcinoma HT-29 cell lines. These results demonstrated the potential of sponge-associated actinomycetes for the discovery of novel and pharmacologically active natural products.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
  • 10
    facet.materialart.
    Unknown
    Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. (2018)
    MDPI
    In:  Marine Drugs, 16 (6, Article Nr. 187).
    Details
    Publication Date: 2021-03-19
    Description: The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of three new (1–3) and four known (4–7) N-terminal glycine- or serine-bearing iso-fatty acid amides esterified with another iso-fatty acid through their C-3 hydroxy groups. The chemical structures of the new compounds were elucidated using a set of spectroscopic (NMR, [α]D and FT-IR) and spectrometric (HRMS, HRMS/MS) methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5) showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22–145 µg/mL). This is the first in-depth chemistry and biological activity study performed on the microbial genus Aequorivita.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OCEANREP)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...