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  • Cham :Springer International Publishing :  (3,224)
  • English  (3,224)
  • German
  • 1
    Online Resource
    Online Resource
    Fuzzy Sets Methods in Image Processing and Understanding : Medical Imaging Applications (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Computer vision. ; Radiology. ; Biotechnology. ; Computer Vision. ; Radiology.
    Description / Table of Contents: Introduction -- Preliminaries -- Fuzzy spatial objects (fuzzy geometry and topology, set theoretic operations) -- Mathematical morphology -- Distances and similarities between fuzzy sets -- Machine learning in image processing and understanding -- Fusion -- Spatial relations -- Structural representations.
    Abstract: This book provides a thorough overview of recent methods using higher level information (object or scene level) for advanced tasks such as image understanding along with their applications to medical images. Advanced methods for fuzzy image processing and understanding are presented, including fuzzy spatial objects, geometry and topology, mathematical morphology, machine learning, verbal descriptions of image content, fusion, spatial relations, and structural representations. For each methodological aspect covered, illustrations from the medical imaging domain are provided. This is an ideal book for graduate students and researchers in the field of medical image processing. This book also: Enriches reader understanding of the latest fuzzy sets methods using higher level information (object or scene level) for advanced tasks, such as image understanding Shares many insights into fuzzy spatial objects, including fuzzy geometry and topology as well as set theoretical operations Covers in detail machine learning in image processing and understanding, with special focus on clustering, classification, and basic and advanced fuzzy methods .
    Type of Medium: Online Resource
    Pages: XIII, 302 p. 97 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194252
    URL: https://doi.org/10.1007/978-3-031-19425-2
    DOI: 10.1007/978-3-031-19425-2
    DDC: 660.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    Sustainable Forest Management in the Himalaya (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Forestry. ; Geography. ; Biotic communities. ; Forestry. ; Regional Geography. ; Ecosystems.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Forest Land Use/Cover Change -- Chapter 3. Forest Classifications and Working Circles -- Chapter 4. National Parks, Wildlife Sanctuaries, and Conservation Reserves -- Chapter 5. Forest Diversity and Distribution -- Chapter 6. Forest Stocks and Products -- Chapter 7. Environmental Index -- Chapter 8. Ecosystem Goods and Services -- Chapter 9. Drivers of Forest Degradation and Conservation Measures -- Chapter 10. Climate Change and Forests -- Chapter 11. Cultural and Socio-Economic Significance of Forests -- Chapter 12. Sustainable Forest Management -- Chapter 13. Conclusions.
    Abstract: This volume presents a comprehensive description of forests of the Uttarakhand Himalaya. It looks into the major drivers of forest depletion and suggests paths toward sustainable forest management. The book comprises thirteen chapters, which together describe forest land use/cover change; forest classification and working circles; national parks, wildlife sanctuaries, and conservation reserves; forest diversity and distribution; forest stocks and products; ecosystem goods and services; environmental index; drivers of forest degradation and conservation; climate change and forests; cultural and economic significance of forests, and sustainable forest management. The text is richly complemented by nearly seventy photographs and figures.
    Type of Medium: Online Resource
    Pages: XXX, 172 p. 71 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219368
    URL: https://doi.org/10.1007/978-3-031-21936-8
    DOI: 10.1007/978-3-031-21936-8
    DDC: 634.9
    Language: English
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  • 3
    Online Resource
    Online Resource
    Mexican Fauna in the Anthropocene (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biodiversity. ; Biotic communities. ; Conservation biology. ; Ecology . ; Vertebrates. ; Invertebrates. ; Biodiversity. ; Ecosystems. ; Conservation Biology. ; Vertebrate Zoology. ; Invertebrate Zoology.
    Description / Table of Contents: 1.1 General Introduction Principal -- 2. Zoloogical Groups -- 2.1 Arachnids -- 2.2 Insects: Migrants, endemics, and old to new pests -- 2.3 Freshwater decapod crustaceans: the challenges of documenting and preserving a very diverse fauna -- 2.4 Mexican molluscs: In the process of a 'silent extinction' -- 2.5 Amphibians and reptiles -- 2.6 Anthropocene impacts on the Mexican freshwater fish fauna -- 2.7 Mexican avifaunas of the Anthropocene -- 2.8 Marine birds -- 2.9 Terrestrial mammals -- 2.10 Marine mammals -- 2.11Mexican bats: conservation challenges in the Anthropocene -- 3. Ecosytems -- 3.1 The impact of the growth of urban environments on Mexican fauna -- 3.2 Anchialine fauna of the Yucatan Peninsula -- 3.3 Semi-terrestrial and aquatic invertebrates and fish in mangroves in México -- 3.4 Defaunation of Mexican tropical forests3.5 Mezcal boom and extinction debts in Mexican arid ecosystems -- 3.6 Deep sea life -- 3.7 The importance of agroecosystems for the Mexican fauna -- 3.8 The salamanders of the Mexican cloud forest -- 3.9 Human effects on caves in Mexico -- 3.10 Fauna of lakes and rivers -- 3.11 Coral reef faunal assemblages in the Mexican Caribbean: assessing the cryptic biodiversity -- 4 Processes -- 4.1 Contemporary climate change impacts on Mexican fauna -- 4.2 Invasive alien species of invertebrates and fishes introduced to Mexican freshwater systems -- 4.3 Are marine fisheries sustainable? -- 4.4 Pest dynamics in Mexican forests -- 4.5 Pollination by wild and managed animal vectors -- 4.6 Social participation strategies for the conservation of Mexican fauna -- 4.7 Citizen science for deep ocean biodiversity: a crowdsourcing tool in support of conservation -- 4.8 Legal actions for the conservation of fauna.
    Abstract: This contributed volume presents an analysis of the current conservation status of major faunal groups in Mexico. The chapters describe a prognosis of future challenges, and also explore the expanding threats inherent in the Anthropocene within the context of the unique physical, biological and cultural aspects of the nation. Covering 27 chapters, and written by Mexican and international authors, this book analyzes a wide range of vertebrate and invertebrate animal taxa, their ecosystems and the critical processes related to their present conservation status. This volume is an important reference material for researchers, conservationists and students interested in the biological and ecological processes shaping the Mexican fauna.
    Type of Medium: Online Resource
    Pages: XVII, 597 p. 50 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031172779
    URL: https://doi.org/10.1007/978-3-031-17277-9
    DOI: 10.1007/978-3-031-17277-9
    DDC: 333.95
    Language: English
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  • 4
    Online Resource
    Online Resource
    Southern Baltic Coastal Systems Analysis (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Biotic communities. ; Social sciences. ; Humanities. ; Environmental management. ; Freshwater and Marine Ecology. ; Water. ; Ecosystems. ; Humanities and Social Sciences. ; Environmental Management.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.
    Abstract: This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and are in relation to social ideals. The assessment will not only be economically and ethically but also the mechanisms that are used for the valorisation of the ecosystem services will be evaluated. Both sub-areas, the classic natural science part as well as the part of social science aspects, deal with the changes caused by increasing anthropogenic influence and social (including demographic) changes. This will be among others in the sense of an exemplary historical outline. The final chapter of the synthesis therefore not only presents a summary of the level of knowledge gained and a deduction of the research needs. It further contains a presentation of the application aspects resulting from the analysis of the social relevance gained from basic scientific research. The book is aimed at scientists (and students) of natural, life and social sciences, analysing functioning and structures of coastal ecosystems with regard to sustainable use and nature protection, including aspects of coastal protection. Besides, it is thought to become a reference for all levels of decision makers and stakeholders in coastal and marine management of the Baltic and North Sea region, providing also a blueprint for system analysis respecting for societal as well as biological aspects world-wide.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031136825
    Series Statement: Ecological Studies, Analysis and Synthesis, 246
    URL: https://doi.org/10.1007/978-3-031-13682-5
    DOI: 10.1007/978-3-031-13682-5
    DDC: 577.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Prions and Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Description / Table of Contents: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Abstract: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Type of Medium: Online Resource
    Pages: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031205651
    URL: https://doi.org/10.1007/978-3-031-20565-1
    DOI: 10.1007/978-3-031-20565-1
    DDC: 612.8
    Language: English
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  • 6
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    Online Resource
    Primates in Anthropogenic Landscapes : Exploring Primate Behavioural Flexibility Across Human Contexts (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Zoology. ; Human evolution. ; Anthropology. ; Physical anthropology. ; Animal culture. ; Zoology. ; Evolutionary Anthropology. ; Physical-Biological Anthropology. ; Animal Science.
    Description / Table of Contents: Introduction -- Part 1-Human Influences on Primate Habitats -- Forest Fragmentation -- Primates in Regenerating Forest -- Responses of primates to roads: Dispersal barriers, mortality, and secondary effects -- Hunting by humans -- Primate-dog interactions -- Primate Tourism -- Infectious disease -- Climate change impacts on non-human primates – what have we modelled and what do we do now? -- PART 2: PRIMATES IN HUMAN-DOMINATED LANSCAPES -- Community-based conservation strategies to promote primate conservation in agricultural landscapes -- Translocated primate populations -- Translocated primate populations -- Exploring the human-primate interface -- Planning primate conservation in shared landscapes -- Non-pathogenic influences on primate health and behaviour -- PART 3: PRIMATES IN CAPTIVITY -- Anthropogenic and observer effects on primate behaviour: Perspectives on the continuum of wild-captive behaviour -- The primate pet trade -- Rescue, rehabilitation, and reintroduction.
    Abstract: The field of primatology has expanded substantially in the last twenty years, particularly with regard to studies of primates in human-altered landscapes. This text aims to review the recent literature on anthropogenic (of human origin) influences on non-human primates, bringing an overview of this important area of primatology together for students. Chapters are grouped into three sections, representing the many ways anthropogenic activities affect primate populations. The first section, ‘Human Influences on Primate Habitat’, covers ways in which wild primates are affected by human actions, including forest fragmentation, climate change, and the presence of dogs. Section two, ‘Primates in Human-Dominated Landscapes’, looks at situations where non-human primates and humans share space; this includes primates in urban environments, primate tourism, and primates in agroecosystems. The final section, ‘Primates in Captivity’, looks at primate behaviour and welfare in captive situations, including zoos, the primate pet trade, and in entertainment.
    Type of Medium: Online Resource
    Pages: XIII, 346 p. 36 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031117367
    Series Statement: Developments in Primatology: Progress and Prospects,
    URL: https://doi.org/10.1007/978-3-031-11736-7
    DOI: 10.1007/978-3-031-11736-7
    DDC: 590
    Language: English
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  • 7
    Online Resource
    Online Resource
    Basic and Clinical Immunology by Names : From the Biblical Time Until the Present (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    URL: https://doi.org/10.1007/978-3-031-14529-2
    DOI: 10.1007/978-3-031-14529-2
    DDC: 571.96
    Language: English
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  • 8
    Online Resource
    Online Resource
    The Secret Lives of Transcription Factors : In Heterochromatin Regulation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Physiology. ; Medical genetics. ; Cell Biology. ; Physiology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.
    Abstract: This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
    Type of Medium: Online Resource
    Pages: VI, 45 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031290299
    Series Statement: SpringerBriefs in Biochemistry and Molecular Biology,
    URL: https://doi.org/10.1007/978-3-031-29029-9
    DOI: 10.1007/978-3-031-29029-9
    DDC: 571.6
    Language: English
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  • 9
    Online Resource
    Online Resource
    Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Aging. ; Cytology. ; Clinical biochemistry. ; Proteins . ; Ageing. ; Cell Biology. ; Medical Biochemistry. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1:Introduction: Historical Development and Progression of Clinical Research on Ageing -- Chapter 2:Bone Cells Metabolic Changes Induced by Ageing -- Chapter 3:Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-related Diseases -- Chapter 4: Heart Disease and Ageing: The roles of Senescence, Mitochondria and Telomerase in Cardiovascular Disease -- Chapter 5: Chronic Kidney Disease and the Exposome of Ageing -- Chapter 6: Sarcopenia and Ageing -- Chapter 7: Tendon Ageing -- Chapter 8: Virus Infections in Older People -- Chapter 9: Models and Biomarkers for Ovarian Ageing -- Chapter 10: Ageing and the Autonomic Nervous System -- Chapter 11: Astrocytes in Ageing -- Chapter 12: Hearing and Ageing -- Chapter 13: Melatonin and Ageing -- Chapter 14: Protein and Energy Supplements for the Elderly -- Chapter 15: Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants -- Chapter 16: Clinical Ageing.
    Abstract: This book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of ageing as seen in clinical practice. To this end, the reader learns about the historical development and progression of clinical ageing research. All chapters address the biochemistry or cell biology of various ageing events (to the extent that the data are available) and work their way to the clinical understanding we have of ageing. The focus of this volume is on how dietary restriction, virus infection and chronic inflammation affect the ageing process. Additionally, this book discusses how phosphate metabolism and metabolic dysfunction contribute to ageing events and how various organs and tissues (e.g. tendons, ears, heart muscle, and the endocrine system) age. This book follows on from Parts I, II and III of Biochemistry and Cell Biology of Ageing within the Subcellular Biochemistry book series and aims to bring the subcellular and clinical areas into closer contact by including interesting and significant biomedical ageing topics that were not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.
    Type of Medium: Online Resource
    Pages: VIII, 458 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031265761
    Series Statement: Subcellular Biochemistry, 103
    URL: https://doi.org/10.1007/978-3-031-26576-1
    DOI: 10.1007/978-3-031-26576-1
    DDC: 571.878
    Language: English
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  • 10
    Online Resource
    Online Resource
    Marine Mammals : A Deep Dive into the World of Science (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Zoology. ; Veterinary medicine. ; Freshwater ecology. ; Marine ecology. ; Zoology. ; Veterinary Science. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Chapter 1. Who are the marine mammals? -- Chapter 2. Marine mammal acoustics -- Chapter 3. Whaling, seal culling, and the effect of fisheries on marine mammals -- Chapter 4. Plastic debris and its impacts on marine mammals -- Chapter 5. Chemical pollution and diseases of marine mammals -- Chapter 6. How to become a marine mammal scientist.
    Abstract: This highly-readable Open Access textbook provides basic background information about marine mammals and anthropogenic impacts on them. The book includes inspiring exercises for education school programs in natural sciences. The book also provides advice on career paths using case studies of marine scientists and veterinarians describing their journeys from student to profession. By sharing real-life career paths, readers find answers to questions such as “What needs to be considered when choosing a career in science?” and “What kind of tasks do scientists undertake on a daily basis?” Marine mammals are amongst some of the most celebrated creatures on Earth, with their high intelligence, social and communicating skills, and capacity for deep diving. Alongside general information about marine mammals, the book aims at generating awareness of the impact of litter and noise pollution on the marine environment using marine mammals as an example. Huge numbers of marine animals, including marine mammals, die every year from entanglement in fishing gear, by ingestion of litter or because of chemical pollution. In the last decade many technological and scientific tools have been developed to aid research, for instance miniaturised sound recorders which can be attached to cetaceans and seals and record noise levels around them, their vocal production as well as their diving behaviour. This Open Access textbook can be used by undergraduate students interested in the fundamentals of marine mammal biology and medicine, and in pursuing the profession of a marine scientist. .
    Type of Medium: Online Resource
    Pages: X, 95 p. 32 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031068362
    URL: https://doi.org/10.1007/978-3-031-06836-2
    DOI: 10.1007/978-3-031-06836-2
    DDC: 590
    Language: English
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  • 11
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    Online Resource
    Neuroimmune Interactions in Pain : Mechanisms and Therapeutics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Description / Table of Contents: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Abstract: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Type of Medium: Online Resource
    Pages: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031292316
    URL: https://doi.org/10.1007/978-3-031-29231-6
    DOI: 10.1007/978-3-031-29231-6
    DDC: 612.8
    Language: English
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  • 12
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    Online Resource
    Machine Learning and Deep Learning in Computational Toxicology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Toxicology. ; Machine learning. ; Artificial intelligence. ; Toxicology. ; Machine Learning. ; Artificial Intelligence.
    Description / Table of Contents: Machine Learning and Deep Learning Promotes Predictive Toxicology for Risk Assessment of Chemicals -- Multi-Modal Deep Learning Approaches for Molecular Toxicity prediction -- Emerging Machine Learning Techniques in Predicting Adverse Drug Reactions -- Drug Effect Deep Learner Based on Graphical Convolutional Network -- AOP Based Machine Learning for Toxicity Prediction -- Graph Kernel Learning for Predictive Toxicity Models -- Optimize and Strengthen Machine Learning Models Based on in vitro Assays with Mecha-nistic Knowledge and Real-World Data -- Multitask Learning for Quantitative Structure-Activity Relationships: A Tutorial -- Isalos Predictive Analytics Platform: Cheminformatics, Nanoinformatics and Data Mining Applications -- ED Profiler: Machine Learning Tool for Screening Potential Endocrine Disrupting Chemicals -- Quantitative Target-specific Toxicity Prediction Modeling (QTTPM): Coupling Machine Learning with Dynamic Protein-Ligand Interaction Descriptors (dyPLIDs) to Predict Androgen Receptor-mediated Toxicity -- Mold2 Descriptors Facilitate Development of Machine Learning and Deep Learning Models for Predicting Toxicity of Chemicals -- Applicability Domain Characterization for Machine Learning QSAR Models -- Controlling for Confounding in Complex Survey Machine Learning Models to Assess Drug Safety and Risk. .
    Abstract: This book is a collection of machine learning and deep learning algorithms, methods, architectures, and software tools that have been developed and widely applied in predictive toxicology. It compiles a set of recent applications using state-of-the-art machine learning and deep learning techniques in analysis of a variety of toxicological endpoint data. The contents illustrate those machine learning and deep learning algorithms, methods, and software tools and summarise the applications of machine learning and deep learning in predictive toxicology with informative text, figures, and tables that are contributed by the first tier of experts. One of the major features is the case studies of applications of machine learning and deep learning in toxicological research that serve as examples for readers to learn how to apply machine learning and deep learning techniques in predictive toxicology. This book is expected to provide a reference for practical applications of machine learning and deep learning in toxicological research. It is a useful guide for toxicologists, chemists, drug discovery and development researchers, regulatory scientists, government reviewers, and graduate students. The main benefit for the readers is understanding the widely used machine learning and deep learning techniques and gaining practical procedures for applying machine learning and deep learning in predictive toxicology. .
    Type of Medium: Online Resource
    Pages: XIX, 635 p. 149 illus., 124 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031207303
    Series Statement: Computational Methods in Engineering & the Sciences,
    URL: https://doi.org/10.1007/978-3-031-20730-3
    DOI: 10.1007/978-3-031-20730-3
    DDC: 615.90072
    Language: English
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  • 13
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    Online Resource
    A Field Guide to Tropical Plant Families (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Botany. ; Plant anatomy. ; Biodiversity. ; Plant Science. ; Plant Anatomy and Morphology. ; Biodiversity.
    Description / Table of Contents: Part I – User manual and architectural concepts. Chapter 1. Introduction -- Chapter 2. How to use this book 6 -- Chapter 3. Architectural concepts and key to the models -- Part II. Identification keys -- Chapter 4. Key to the groups of families of trees and shrubs (groups 1 to 52) -- Chapter 5. Keys to families of trees and shrubs -- Chapter 6. Supplementary keys -- Chapter 7. Keys to the groups of families of lianas and woody epiphytic (groups 53 to 57) -- Chapter 8. Keys to families of lianas and woody epiphytes -- PART III. Description of the families -- Chapter 9. Acanthaceae to Asteraceae -- Chapter 10. Bignoniaceae to Buxaceae -- Chapter 11. Cactaceae to Cycadaceae -- Chapter 12. Dichapetalaceae to Dipterocarpaceae -- Chapter 13. Ebenaceae to Euphorbiaceae -- Chapter 14. Fagaceae -- Chapter 15. Gentianaceae to Goupiaceae -- Chapter 16. Hamamelidaceae to Humiriaceae -- Chapter 17. Icacinaceae s.l. to Irvingiaceae -- Chapter 18. Juglandaceae -- Chapter 19. Lamiaceae to Lythraceae -- Chapter 20. Magnoliaceae to Myrtaceae -- Chapter 21. Nyctaginaceae,- Chapter 22. Ochnaceae to Oxalidaceae -- Chapter 23. Pandaceae to Putranjivaceae -- Chapter 24. Rhabdodendraceae to Rutaceae -- Chapter 25. Sabiaceae to Symplocaceae -- Chapter 26. Tetramelaceae to Torricelliaceae -- Chapter 27. Ulmaceae s.l. to Urticaceae -- Chapter 28. Verbenaceae to Vochysiaceae -- Chapter 29. Zygophyllaceae s.l -- Chapter 30. Herbaceous versus arborescent habit in the families and orders of flowering plants - evolutionary trends.
    Abstract: This book provides an identification system permitting recognition of plant families in all seasons by means of morphological and macroanatomical features which are easily observable, such as bark, exudates, stems and leaves characters. Studies of forest vegetation may differ in their underlying objectives, but they all require taxonomic knowledge. The process of taxonomy begins with an inventory of the flora, which has been based to a large extent on reproduction-related organs, such as flowers and fruits. But, those are often difficult to observe and may not exist in the field at a given time. Unlike most such guides or keys, this book can be used anywhere in the tropics and provides, in a straightforward two or three-step process, identification to the level of families, which are now circumscribed according to molecular as well as morphological characters in the universally accepted scheme of the Angiosperm Phylogeny Group. Plant architecture is not a prerequisite theme for plant identification; however, we think that an introduction to this subject is not out of place in this book (architectural traits are taxonomically sound): it is now time for botanists working in the tropics to have an idea on how the whole organism keeps growing. Within the family accounts, there is information concerning important economic plants with notes on the larger genera and, particularly helpfully, discussion of families readily confused and how to separate them. Descriptions of the families rely on short diagnosis bolstered by many photographic pictures, lines drawings and extracts from the author’s field books, all showing features of plants as they are found in the forest.
    Type of Medium: Online Resource
    Pages: XVII, 494 p. 909 illus., 850 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031059421
    URL: https://doi.org/10.1007/978-3-031-05942-1
    DOI: 10.1007/978-3-031-05942-1
    DDC: 580
    Language: English
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  • 14
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    Online Resource
    Smart Livestock Nutrition (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Veterinary medicine. ; Agriculture. ; Physiology. ; Agricultural genome mapping. ; Animal welfare Moral and ethical aspects. ; Veterinary Science. ; Agriculture. ; Animal Physiology. ; Agricultural Genetics. ; Animal Ethics.
    Description / Table of Contents: Chapter 1. Putting Smart into Nutrition -- Chapter 2. Mozatching Feed Characteristics to Animal Requirements Through Plant Breeding -- Chapter 3. Circular Feed Production and Consumption in The Context Of Smart Animal Nutrition -- Chapter 4. Assessment of The Nutritive Value of Individual Feeds and Diets by Novel Technologies -- Chapter 5. Large Scale Phenotyping and Genotyping: State of The Art and Emerging Challenges -- Chapter 6. Mathematical and Statistical Approaches to The Challenge of Forecasting Animal Performance for The Purposes of Precision Livestock Feeding -- Chapter 7. Smart Pig Nutrition in the Digital Era -- Chapter 8. Smart Poultry Nutrition -- Chapter 9. Advanced Technology in Aquaculture – Smart Feeding in Marine Fish Farms -- 10. Smart Nutrition of Extensively Kept Ruminants -- Chapter 11. The Potential Contribution of Smart Animal Nutrition in Reducing The Environmental Impacts of Livestock Systems.
    Abstract: This book highlights the latest findings and techniques related to nutrition and feed efficiency in animal agriculture. It addresses the key challenges facing the nutrition industry to achieve high animal productivity with minimal environmental impact. The concept of smart nutrition involves the use of smart technologies in the feeding and management of livestock. The first chapters focus on advances in biological fields such as molecular agriculture and genotype selection, as well as technologies that enhance or enable the collection of relevant information. The next section highlights applications of smart nutrition in a variety of livestock systems, ranging from intensive indoor housing of broilers and pigs to extensive outdoor housing of cattle and sheep, and marine fish farms. Finally, because of the worldwide attention to this issue, the authors address the environmental consequences. This work, which takes a serious look at how nutrition can be used to improve sustainability in animal agriculture, is a key literature for readers in animal and veterinary sciences, the food industry, sustainability research, and agricultural engineering.
    Type of Medium: Online Resource
    Pages: VIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031225840
    Series Statement: Smart Animal Production, 1
    URL: https://doi.org/10.1007/978-3-031-22584-0
    DOI: 10.1007/978-3-031-22584-0
    DDC: 636.089
    Language: English
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  • 15
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    Online Resource
    Baking Business Sustainability Through Life Cycle Management (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Food science. ; Sustainability. ; Family-owned business enterprises. ; Economics. ; Food Science. ; Sustainability. ; Family Business. ; Economics.
    Description / Table of Contents: Chapter 1 Bread Industry Sustainability Life Cycle Assessment -- Chapter 2 Product Environmental Footprint and Bread Industry -- Chapter 3 Life Cycle Assessment and Product Environmental Footprint - recommendations for integral optimization of economic and environmental performance -- Chapter 4 Ensuring sustainability of baking industry in North Macedonia -- Chapter 5 Sustainability approach of the baking industry along the food supply chain -- Chapter 6 Sustainability assessment of the baking industry complying with standards requirements: a case of Romania -- Chapter 7 Across American overview on sustainability approach throughout baking industry: An analytical-descriptive approach -- Chapter 8 Asian Overview on Sustainability Approach in Baking Industry -- Chapter 9 African Experience in Ensuring Sustainability in Baking -- Chapter 10 Indian experience in ensuring sustainability in baking industry -- Chapter 11 Measuring Baking Business Performance -- Chapter 12 Forming the efficient business model for bakery -- Chapter 13 Assessment of the sustainable competitiveness of agricultural enterprises on the grain market: case of Ukraine -- Chapter 14 Economic viability and sustainability in baking industry/ Simeuna - bread producer with own grain production -- Chapter 15 Impact of Bakery Innovation on Business Resilience Growth -- Chapter 16 Innovation in the commercial system of the small bakery industry -- New business models in food systems for farmers and companies, based on multi-actor approach -- Chapter 18 The role of rural women in bread industry – Job creation and retention in rural areas.
    Abstract: This timely and comprehensive text focuses on important recent advances in applied sustainability in the baking industry, connecting all of the current methods and strategies into a single book. Those involved in bread production will find the latest developments at the theoretical and practical levels, including information and communication requirements, reporting and regulatory aspects, economic and environmentally sustainable business models, supply chain management, life cycle assessment, product and organizational environmental footprints and more. For small bakery business owners to industry leaders and policymakers, governmental authorities, regulatory authorities and standardization bodies, this book offers a compilation of technical information about sustainability in the market for the bakery sector. Baking Business Sustainability Through Life Cycle Management begins by presenting basic information on the life cycle assessment and product environmental footprint of the bread industry, proposing an analysis of sustainability assessment using environmental and social footprints and providing recommendations for integral optimization of economic and environmental performance. A second section focuses on sustainability in the baking industry, providing a regional focus from Europe to the Americas to Africa and Asia. The third section takes a deep look at economic feasibility and efficiency in the bread industry, including the economic viability of different scenarios for bread-based value chains, and forming efficient business models for bakeries. A final section zeroes in on the most up-to-date innovations in the current bakery industry, including the impact of bakery innovation on business resilience growth, commercial systems, and new business models in regional food systems for farmers and companies, based on multi-actor approach. Innovations within the bakery industry are at an all-time high, with new sustainability and economic models being introduced, along with associated market risks. This timely and ambitious text aims to cover all the most recent advances and methods for successful incorporation into bakery businesses. .
    Type of Medium: Online Resource
    Pages: VIII, 313 p. 74 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031250279
    URL: https://doi.org/10.1007/978-3-031-25027-9
    DOI: 10.1007/978-3-031-25027-9
    DDC: 641.3
    Language: English
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  • 16
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    Online Resource
    Metabolism of Alimentary Compounds by the Intestinal Microbiota and Health (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Nutrition   . ; Medical microbiology. ; Human physiology. ; Medicine, Preventive. ; Health promotion. ; Nutrition. ; Medical Microbiology. ; Human Physiology. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Chapter 1. Physiological and Metabolic Functions of the Intestinal Epithelium: From the Small to the Large Intestine -- Chapter 2. Intestine Offers Board and Lodging for Intestinal Microbes on a Short- or Long-Term Stay -- Chapter 3. Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine -- Chapter 4. Alimentation, Bacterial Metabolites, and Host Intestinal Epithelium -- Chapter 5. Modification of the Bacterial Metabolites by the Host after Absorption, and Consequences for the Peripheral Tissues’ Metabolism, Physiology, and Pathophysiology -- Chapter 6. Lessons to Be Learned from Clinical and Experimental Research on the Intestinal Microbiota Metabolic Activity for Health Benefit and Perspectives.
    Abstract: This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues. Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented. Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.
    Type of Medium: Online Resource
    Pages: XIII, 254 p. 57 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263224
    URL: https://doi.org/10.1007/978-3-031-26322-4
    DOI: 10.1007/978-3-031-26322-4
    DDC: 613.2
    Language: English
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  • 17
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    Online Resource
    Engineering Translational Models of Lung Homeostasis and Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Regenerative medicine. ; Biomedical engineering. ; Cytology. ; Biomaterials. ; Cells. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering. ; Cell Biology. ; Biomaterials-Cells. ; Biotechnology. ; Biomaterials.
    Abstract: Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: X, 326 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031266256
    Series Statement: Advances in Experimental Medicine and Biology, 1413
    URL: https://doi.org/10.1007/978-3-031-26625-6
    DOI: 10.1007/978-3-031-26625-6
    DDC: 612.028
    Language: English
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  • 18
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    Online Resource
    The Renin Angiotensin System in Cardiovascular Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    URL: https://doi.org/10.1007/978-3-031-14952-8
    DOI: 10.1007/978-3-031-14952-8
    DDC: 610.72
    Language: English
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  • 19
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    Online Resource
    Social and Affective Neuroscience of Everyday Human Interaction : From Theory to Methodology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Cognitive neuroscience. ; Psychobiology. ; Human behavior. ; Sociology. ; Neuroscience. ; Cognitive Neuroscience. ; Behavioral Neuroscience. ; Sociology.
    Description / Table of Contents: Molecular imaging of the human emotion circuit -- The neurocognitive mechanisms of unconscious emotional responses -- Social and Affective Neuroscience of Embodiment -- The neuroscience of beauty -- Mirror Neurons … in action: ERPs and neuroimaging evidence -- Sex differences in social cognition -- Development of morality and emotional processing -- Trust in Social Interaction: From Dyads to Civilizations -- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode -- Social Cognition development and socio affective dysfunction in childhood and adolescence -- Clinical neuroscience meets second-person neuropsychiatry -- EEG and ERPs in the study of Language and Social Knowledge -- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities -- Modulating the Social and Affective Brain with transcranial stimulation techniques -- What our eyes can tell us about our social and affective brain? -- Facial EMG – Investigating the interplay of facial muscles and emotions.
    Abstract: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Type of Medium: Online Resource
    Pages: XXXIII, 302 p. 55 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031086519
    URL: https://doi.org/10.1007/978-3-031-08651-9
    DOI: 10.1007/978-3-031-08651-9
    DDC: 612.8
    Language: English
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  • 20
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    Online Resource
    Careers in Food Science: From Undergraduate to Professional (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Food science. ; Chemistry. ; Food Science. ; Chemistry.
    Description / Table of Contents: Section 1: Introduction -- 1. Introduction: Career Preparation for the Food & Beverage Industry -- 2. The Equilibrium of Life-Career Planning -- 3. First Jobs for Food Science -- Section 2: The undergraduate student experience -- 4. Making the Most of Your Undergraduate Experience -- 5. Campus Career Services and Centers -- 6. Professionalism and Leadership -- 7. Is Food Science Right For Me? The Transfer Experience -- 8. The Decision to Pursue an Internship -- 9. IFT Student Association -- Section 3: A successful industry career -- 10. Finding and negotiating a job -- 11. Employer expectations/Managing corporate life -- 12. Could a small company be for you? -- 13. A successful industry career or Making your way in a company -- Section 4: Careers with a degree in food science -- 14. Quality -- 15. Production management -- 16. Product development -- 17. Technical sales -- 18. R&D -- 19. Regulatory and food law -- 20. Careers in Traceability -- 21. Using food science in special interest groups -- 22. Food for Good: Leveraging Food Science to Feed the World -- 23. Careers that combine Culinary and Food Science -- 24. Entrepreneurship and Consulting: Taking a Different Path -- 25. Careers in Sensory Science -- 26. Food Science in Community-Based Food Systems -- 27. Working for a Startup Company -- 28. Careers in Sustainability -- 29. A Career in Management -- Section 5: The graduate student experience -- 30. Is grad school right for me? -- 31. Finding and getting into the right grad program -- 32. The transition from undergraduate to graduate student -- 33. Faculty expectations of graduate students.
    Abstract: Careers in Food Science provides detailed guidelines for students and new employees in the food industry to ensure a successful start to their career. Every step towards a rewarding career in this rapidly evolving industry is covered, from which classes to take in college and which degrees to earn, to internships, and finally how to land, and keep, the first job. This book also provides day-to-day examples of what to expect from the many jobs available to help students decide what to do and where to go. This second edition includes nine new chapters covering research chefs, food systems, social justice, food waste, start-ups, sustainability, and management. Several new authors offer fresh perspectives. Provides detailed guidelines for students as well as new employees in food industry; Includes perspectives from school years through how to succeed at new job; Written by individuals who have just gone through that experience or who are working in that particular sector.
    Type of Medium: Online Resource
    Pages: XII, 411 p. 5 illus., 1 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031143533
    URL: https://doi.org/10.1007/978-3-031-14353-3
    DOI: 10.1007/978-3-031-14353-3
    DDC: 641.3
    Language: English
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  • 21
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    Online Resource
    Emerging Nanomaterials : Opportunities and Challenges in Forestry Sectors (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Forestry. ; Nanotechnology. ; Botany. ; Biotechnology. ; Anatomy. ; Genetics. ; Forestry. ; Nanotechnology. ; Plant Science. ; Biotechnology. ; Anatomy. ; Genetics and Genomics.
    Description / Table of Contents: Preface -- Chapter. 1. Emerging nanomaterials for forestry and associated sectors: An overview -- Chapter. 2. Potential of Nanomaterials in Bio-Based Wood Adhesives: An Overview -- Chapter. 3. Nanomaterials to improve fire properties in wood and wood-based composite panels -- Chapter. 4. Wood Plastic Composites (WPC): Applications of Nanomaterials -- Chapter. 5. Nanomaterials to improve properties in wood-based composite panels -- Chapter. 6. Nanomaterials to improve the strength of wooden joints -- Chapter. 7. Application of nanomaterials for wood protection -- Chapter. 8. Nanocellulose in paper and board coating -- Chapter. 9. Green Materials for Radiation Shielding: An overview -- Chapter. 10. Formaldehyde emissions from wood-based composites: Effects of nanomaterials.
    Abstract: Bio-based materials, including those containing wood, will become increasingly important as we move to a bio-based economy. Among their many attributes, it is vitally important that these materials are renewable, sustainable with proper management and environmentally benign. Wood remains one of our most important bio-based materials. While it is an amazing material, wood still has negative attributes and drawbacks that can affect performance, including dimensional instability when wetted, vulnerability to fire and high temperatures, and susceptibility to biodeterioration. A variety of treatments have been developed to overcome these weaknesses. Among the most exciting of these treatments are nanomaterials. These materials have some exceptionally attractive properties for improving timber performance and have been the subject of intensive research over the past decade. There is a tremendous need for a single comprehensive source of information on this rapidly emerging subject with tremendous potential to enhance the performance of a variety of bio-based materials. This book contains 10 chapters, each compiled by different author(s) who are considered the top researcher(s) in their respective fields. The chapters begin with some basic background on nanomaterials and their synthesis, then explore different areas for potential applications and conclude with a review of the emerging questions about nanomaterial safety. The book is designed to provide the latest information and know-how on application and utilization of different nanomaterials to improve the properties of wood and wood-based composite panels. The contents cover some main topics in the industry including improving physical and mechanical properties, increasing resistance to biodegradation (including fungi and insects), developing wood-plastic composites (WPC), applying nanomaterials in paper and board industry, and emergence of transparent wood and radiation shielding. It also covers the use of nanomaterials to improve the performance of paints and finishes used for forest products. The book provides a single location for those interested in the field to begin.
    Type of Medium: Online Resource
    Pages: X, 362 p. 85 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173783
    URL: https://doi.org/10.1007/978-3-031-17378-3
    DOI: 10.1007/978-3-031-17378-3
    DDC: 634.9
    Language: English
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  • 22
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    Online Resource
    Plant Relationships : Fungal-Plant Interactions (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Plant diseases. ; Microbial genetics. ; Plant physiology. ; Fungi. ; Mycology. ; Plants. ; Microbiology. ; Plant Pathology. ; Microbial Genetics. ; Plant Physiology. ; Fungi. ; Plant Signalling.
    Description / Table of Contents: Part I. Pathogenic Fungus – Plant Interactions -- Modulation of Host Immunity and Development by Ustilago Maydis -- RNA Dialogues in Fungal-Plant Relationships -- The Role of Tox Effector Proteins in the Parastagonospora Nodorum-Wheat Interaction -- Part II. Mutualistic Fungus – Plant Interactions -- Genomes of Arbuscular Mycorrhizal Fungi -- Diversity of Seed Endophytes: Causes and Implications -- Lichens and Their Allies Past and Present -- Lichen Fungal Secondary Metabolites: Progress in the Genomic Era Towards Ecological Roles in the Interaction -- Part III. Sensing and Signalling in Fungus-Plant Interactions -- Regulation of Plant Infection Processes by MAP Kinase Pathways in Ascomycetous Pathogens -- Role of pH in the Control of Fungal MAPK Signalling and Pathogenicity -- Role of Volatile Organic Compounds in Establishment of the Trichoderma-Plant Interaction -- Part IV. Regulation of Fungal Gene Expression and Development -- Epigenetic Regulation of Fungal Genes Involved in Plant Colonization -- Toward Understanding the Role of Chromatin in Secondary Metabolite Gene Regulation in the Rice Pathogen Fusarium Fujikuroi -- The Rice Blast Fungus Magnaporthe Oryzae Uses a Turgor-Dependent, Septin-Mediated Mechanism to Invade Rice -- Role of Light in the Life Cycle of Botrytis Cinerea -- Part V. Genomes and Evolution -- Species of Zymoseptoria (Dothideomycetes) as a Model System to Study Plant Pathogen Genome Evolution -- Accessory Chromosomes of the Fusarium Oxysporum Species Complex and Their Contribution to Host Niche Adaptation -- Part VI. Global Pandemics and Food Security -- Global Landscape of Rust Epidemics by Puccinia Species: Current and Future Perspectives -- Magnaporthe oryzae and Its Pathotypes: A Potential Plant Pandemic Threat to Global Food Security.
    Abstract: This fully revised 3rd edition provides a comprehensive overview of the biology of fungi associated with plants. Since the publication of the 2nd Edition in 2009, tremendous new knowledge has been gained in the field of fungal-plant interactions, which is reflected in the contributions of this book. World-leading scientists in the field provide authoritative insights into fungal-plant interactions covering the following main topics: Mutualistic and pathogenic fungal-plant interactions in natural and agricultural ecosystems Sensing and signalling in fungus-plant interactions Regulation of fungal gene expression and development Fungal genomes and evolution Global pandemics caused by fungal pathogens and their implications for food security This volume will be of great interest to both specialists and generalists. It is an indispensable resource for researchers, lecturers and students in microbiology, mycology, and plant sciences, as well as agriculture and biotechnology.
    Type of Medium: Online Resource
    Pages: XXII, 462 p. 70 illus., 62 illus. in color. , online resource.
    Edition: 3rd ed. 2023.
    ISBN: 9783031165030
    Series Statement: The Mycota, A Comprehensive Treatise on Fungi as Experimental Systems for Basic and Applied Research, 5
    URL: https://doi.org/10.1007/978-3-031-16503-0
    DOI: 10.1007/978-3-031-16503-0
    DDC: 579
    Language: English
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  • 23
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    Online Resource
    The Basics of Molecular Biology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Molecular biology. ; Cytology. ; Genetics. ; Virology. ; Cancer. ; Enzymology. ; Molecular Biology. ; Cell Biology. ; Genetics. ; Virology. ; Cancer Biology. ; Enzymology.
    Description / Table of Contents: Introduction -- The major processes in the biological world -- Enzymes, conformational changes, energy, and molecular motors -- The cells -- Genome -- Regulation of gene expression and protein activity -- DNA replication, its fidelity, mutations, and repair -- Transduction of signals -- Multicellular organisms and their development -- Biological defense I. Protection from foreign nucleic acids -- Biological defense II. The immune system of vertebrates -- Pathogens -- Cancer -- Index.
    Abstract: Accessible and comprehensive, this book describes the universal cellular nature of living organisms and is an indispensable tool for anyone in the sciences who wishes to get a quick overview of molecular biology. Individual chapters cover nucleic acids and proteins, genetic code and protein synthesis, the fidelity of transferring genetic information to the next generations, and the regulation of various processes inside the cells. Special attention is paid to new areas rising from modern DNA sequencing technologies which transform biology. The book also touches on developing areas, such as cures for cancer and CRISPR, which are important for medicine and the future of humankind. .
    Type of Medium: Online Resource
    Pages: XIV, 184 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194047
    URL: https://doi.org/10.1007/978-3-031-19404-7
    DOI: 10.1007/978-3-031-19404-7
    DDC: 572
    Language: English
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  • 24
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    Online Resource
    Matrix Pathobiology and Angiogenesis (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Blood-vessels Growth. ; Cytology. ; Clinical biochemistry. ; Angiogenesis. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Fibronectin Fibrillogenesis during Angiogenesis -- Chapter 2: Functional Interplay Between Fibronectin and Matricellular Proteins in the Control of Endothelial Tubulogenesis -- Chapter 3: Endothelial Cell-Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors -- Chapter 4: Collagens and collagen-degrading enzymes in the regulation of angiogenesis -- Chapter 5: Kruppel-like factor 2 and matrix metalloproteinases in the context of vasculature -- Chapter 6: Extracellular Matrix-Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds -- Chapter 7: Cell - extracellular matrix adhesions in vascular endothelium -- Chapter 8: Hypoxia: a potent regulator of angiogenesis through extracellular matrix remodeling -- Chapter 9: Leading roles of heparan sulfate in angiogenesis and cancer -- Chapter 10: The role of pericytes in tumor angiogenesis -- Chapter 11: Lymphatic Mechanoregulation in Development and Disease.
    Abstract: In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: XXVII, 320 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031196164
    Series Statement: Biology of Extracellular Matrix, 12
    URL: https://doi.org/10.1007/978-3-031-19616-4
    DOI: 10.1007/978-3-031-19616-4
    DDC: 571.8
    Language: English
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  • 25
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    Online Resource
    Advances in Research on Vegetable Production Under a Changing Climate Vol. 2 (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Agriculture. ; Environment. ; Plant genetics. ; Agriculture. ; Environmental Sciences. ; Plant Genetics.
    Description / Table of Contents: Chapter 1 Advances in research trends in vegetables under a changing climate: A way forward -- Chapter 2 Emerging obstacles of vegetable production due to climate change and mitigation strategies -- Chapter 3 Impact of climate change on nutraceutical properties of vegetables -- Chapter 4 Nutritional stress management in vegetable crops under changing climate scenario -- Chapter 5 Impact of climate change on tuber crops production and mitigation strategies -- Chapter 6 Impact of climate change on leafy vegetables and mitigation strategies -- Chapter 7 Impact of climate change on perennial vegetable production and mitigation strategies -- Chapter 8 Impact of climate change on vegetables seed production and mitigation strategies -- Chapter 9 Protected cultivation of high-value vegetables crop under changing climate -- Chapter 10 Impact of climate change on underexploited vegetable crops production and mitigation strategies -- Chapter 11 Improvement of vegetables through grafting techniques in changing climate scenario -- Chapter 12 Improvement of vegetables through molecular breeding in changing climate scenario -- Chapter 13 Kitchen gardening for nutritional security under changing climate -- Chapter 14 Emerging insect-pests of vegetables due to changing climate -- Chapter 15 Emerging diseases of vegetables due to changing climate -- Chapter 16 Impact of climate change on postharvest quality of vegetables.
    Abstract: This second volume on the topic will be extremely useful for the researchers and postgraduate students working on vegetable crops with a special focus on climate change. Today, the entire world is suffering from global warming and its consequent, climate change. This has emerged as the most prominent global environmental issue and there is an urgent need to mitigate its impact on agriculture. Over the past 20 years South Asia has had a robust economic growth, yet it is home to more than one fourth of the world’s hunger and 40% of the world’s malnourished children and women. Persistent climatic variability, which results in frequent drought and flood, is among the major reasons for this phenomenon. Vegetables are in general more succulent (have 90% water) and more sensitive to climatic vagaries and sudden changes in temperature, as well as irregular precipitation at any phase of crop growing, can affect the normal growth, flowering, pollination, fruit setting, fruit development and fruit ripening which eventually decreases the yield. The irregular precipitation also causes the soil salinity and is a major challenge in many vegetable growing areas. To mitigate the harmful impact of climatic change there is an urgent need to develop adequate adaptation strategies for adverse effect of climate change and preference should be given to the development of heat, cold, drought, flood and salinity stress tolerant genotypes along with climate proofing through conventional and non-conventional breeding techniques, as well as exploiting the beneficial effects of CO2 enhancement on crop growth and yield. Available evidence shows that there is high probability of increase in the frequency and intensity of climate related natural hazards due to climate change and hence increase the potential threat due to climate change related natural disasters in the world. At present protected cultivation and grafted seedlings are also popularizing among vegetable growers because of the huge scope as well as, molecular breeding, emerging insect-pests & diseases and postharvest quality of vegetables under this climate change scenario. Moreover, underexploited vegetables, perennial vegetable and tuber crops have a more tolerant ability to climate vagaries compare to major vegetables which are also discussed in this book.
    Type of Medium: Online Resource
    Pages: XVII, 369 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031208409
    Series Statement: Advances in Olericulture,
    URL: https://doi.org/10.1007/978-3-031-20840-9
    DOI: 10.1007/978-3-031-20840-9
    DDC: 630
    Language: English
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    Priority-Zone Mapping for Reforestation : Case Study in the Montane Dry Forests of Bolivia (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Forestry. ; Environmental management. ; Geographic information systems. ; Sustainability. ; Forestry. ; Environmental Management. ; Geographical Information System. ; Sustainability.
    Abstract: Andean dry forest ecosystems are threatened by deforestation and unsustainable land use methods. The negative effects for the livelihood of the local population, biodiversity, and the regional climate could be countered by reforestation measures; however, dry land forests have not attracted the same level of interest and investment like other ecosystems. This book describes the development of a priority-zone map for reforestation measures, showing where reforestation might have the greatest social and ecological benefits. To achieve this, a problem analysis of a case study region is conducted and thematic reforestation benefits are determined. Using remote sensing and GIS, the areas where benefits can be obtained are mapped in individual layers and compiled into a summarizing priority-zone map. It is thus possible to identify areas where reforestation would achieve multiple benefits. The concept of priority maps could be used to facilitate reforestation strategies by local communities and municipal governments and could thus contribute to initiate an integrated forest and landscape restoration of the Bolivian montane dry forests.
    Type of Medium: Online Resource
    Pages: XVII, 97 p. 42 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031203756
    Series Statement: SpringerBriefs in Geography,
    URL: https://doi.org/10.1007/978-3-031-20375-6
    DOI: 10.1007/978-3-031-20375-6
    DDC: 634.9
    Language: English
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    Online Resource
    History of Arbovirology: Memories from the Field : Volume I: Personal Reflections (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    URL: https://doi.org/10.1007/978-3-031-21999-3
    DOI: 10.1007/978-3-031-21999-3
    DDC: 579.2
    Language: English
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    Online Resource
    Multispecies Biofilms : Technologically Advanced Methods to Study Microbial Communities (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biofilms. ; Microbial populations. ; Bacteria. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Biofilms. ; Microbial Communities. ; Bacteria. ; Fungi. ; Medical Microbiology.
    Description / Table of Contents: 3M’s of Multi-Species Biofilms: Microbial Pathogens, Microenvironments and Minimalist Laboratory Approaches to Study Multi-Species Biofilms under Microenvironmental Conditions -- Methods for the visualization of multispecies biofilms -- In vitro, in vivo and ex vivo models to study mixed bacterial and fungal biofilms -- Current and emerging in vitro and in vivo biofilm models in investigating fungal-bacterial polymicrobial communities: Fungal-bacterial biofilm models -- Involvement of bacterial outer membrane vesicles in cell-cell interactions and their role in multi-species communities -- Polymicrobial biofilm models: the case of periodontal disease as an example -- Polymicrobial biofilms in cystic fibrosis lung infections: effects on antimicrobial susceptibility -- High resolution methods to study microbial interactions in biofilms -- Unity in Diversity: Interkingdom Polymicrobial Biofilms in Disease.
    Abstract: In an age of antibiotic resistant infections, the study of biofilms is increasingly important. Microbes more than often exist in complex multi-species or polymicrobial communities, making infections difficult to detect, diagnose and treat. Given the increased focus on studying biofilms in research and laboratory settings, particularly under conditions that closely mimic the clinical state, it is important to get an overview of the recent methods, model systems and tools being developed and employed in this context. This book offers readers the opportunity to learn more about current methods being used in the investigation of multi-species biofilms, both in vivo and in vitro. For this, the book highlights new technologies built and designed for the study of multiple species within biofilm communities, including those that can be leveraged for the evaluation of antimicrobial treatment approaches. The application of these state-of-the-art techniques to further our understanding of multi-species biofilms will be discussed and the reader will learn how the clinical microenvironment and the development of biofilm communities are considered when developing such tools. With cutting-edge contributions from experts in the respective domains, this book will benefit translational and basic research scientists, as well as clinicians, and is an informative resource for educators and their students. .
    Type of Medium: Online Resource
    Pages: VI, 321 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031153495
    Series Statement: Springer Series on Biofilms, 12
    URL: https://doi.org/10.1007/978-3-031-15349-5
    DOI: 10.1007/978-3-031-15349-5
    DDC: 579.17
    Language: English
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    Pharmacoresistance in Epilepsy : From Genes and Molecules to Promising Therapies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Pharmacology. ; Neuroscience. ; Neurology. ; Pharmacology.
    Description / Table of Contents: Chapter 1: Why study Drug Resistant Epilepsy? -- Chapter 2: Pharmacoresistance in Epilepsy -- Chapter 3: Experimental models for the study of drug-resistant epilepsy -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- Chapter 5: Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- Chapter 6: Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level? -- Chapter 7: Changes in Targets as an Explanation for Drug Resistance in Epilepsy -- Chapter 8: Cellular and molecular mechanisms of neuroinflammation in drug-resistant epilepsy -- Chapter 9: Contribution of the antiepileptic drug administration regime to avoid the development and/or establishment of pharmacoresistant epilepsy -- Chapter 10: Pharmacogenetics in Epilepsy and Refractory Epilepsy -- Chapter 11: Seizures Induce Hypoxia or Hypoxia Induces Seizures. A Perverse Relationship that Increases the Risk of SUDEP -- Chapter 12: Neonatal excitotoxicity triggers degenerative processes related to seizure susceptibility and pharmacoresistance -- Chapter 13: Cerebrovascular remodeling and the role of vascular endothelial growth factor in the epileptic brain and pharmacoresistance -- Chapter 14: The Role of JNK3 in Epilepsy and Neurodegeneration -- Chapter 15: Application of proteomics in the study of molecular markers in epilepsy -- Chapter 16: GABAergic neurotransmission abnormalities in pharmacoresistant epilepsy: experimental and human studies -- Chapter 17: Genes involved in pharmacoresistant epilepsy -- Chapter 18: Drug-resistant Epilepsy and the Influence of Age, Gender and Comorbid Disorders -- Chapter 19: Indications for Intracerebral Recording in Candidates for Epilepsy Surgery -- Chapter 20: On the Development of New Drugs for the Treatment of Drug Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses -- Chapter 21: Physical exercise as a strategy to reduce seizure susceptibility -- Chapter 22: Ketogenic Diet and Drug-resistant Epilepsy -- Chapter 23: Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy -- Chapter 24: Vagus Nerve Stimulation for Intractable Seizures -- Chapter 25: Non Invasive Brain Stimulation as a potential Therapeutic Procedure in drug-resistant epilepsy -- Chapter 26: Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.
    Abstract: This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
    Type of Medium: Online Resource
    Pages: XV, 596 p. 84 illus., 79 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031365263
    URL: https://doi.org/10.1007/978-3-031-36526-3
    DOI: 10.1007/978-3-031-36526-3
    DDC: 612.8
    Language: English
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    Online Resource
    Therapeutic Applications of Dopamine D3 Receptor Function : New Insight After 30 Years Of Research (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.
    Abstract: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031230585
    Series Statement: Current Topics in Behavioral Neurosciences, 60
    URL: https://doi.org/10.1007/978-3-031-23058-5
    DOI: 10.1007/978-3-031-23058-5
    DDC: 615
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    Biomedical Visualisation : Volume 14 ‒ COVID-19 Technology and Visualisation Adaptations for Biomedical Teaching (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Abstract: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Type of Medium: Online Resource
    Pages: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031171352
    Series Statement: Advances in Experimental Medicine and Biology, 1397
    URL: https://doi.org/10.1007/978-3-031-17135-2
    DOI: 10.1007/978-3-031-17135-2
    DDC: 610.72
    Language: English
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    Dose Optimization in Digital Radiography and Computed Tomography : An Essential Guide (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Radiation dosimetry. ; Radiology. ; Radiography, Medical. ; Nuclear medicine. ; Radiation Dosimetry and Protection . ; Radiology. ; Radiography. ; Nuclear Medicine.
    Description / Table of Contents: Dose Optimization: A Useful Tool in Radiation Protection -- Digital Radiography: A Technical Review -- Optimization Strategies in Digital Radiography -- Computed Tomography: A Technical Review.
    Abstract: This book addresses radiation protection of patients having digital radiography and computed tomography (CT) examinations. The literature on radiation doses to patients from these two modalities have reported that the doses to patients are high. As a result, the radiology community has focused on methods and procedures to keep these doses as low as reasonably achievable (ALARA) without compromising the diagnostic image quality. This book outlines the motivation for dose optimization in radiology, identifies and describes the ICRP principle of optimization, outlines the factors affecting the dose in digital radiography and in CT, and identifies and describes strategies used in digital radiography and in CT for dose optimization. This book is intended for all those working in digital radiography and CT environments including radiological technologists, and radiographers, radiologists, biomedical engineering technologists, and student medical physicists. It is best used as a supplement to radiologic science textbooks, and in particular, radiation protection textbooks. Furthermore, this book lays the foundations for students and practitioners engaged in research on dose reduction and dose optimization in radiology.
    Type of Medium: Online Resource
    Pages: XIII, 102 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031228711
    URL: https://doi.org/10.1007/978-3-031-22871-1
    DOI: 10.1007/978-3-031-22871-1
    DDC: 571.45
    Language: English
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    Development of the Cerebellum from Molecular Aspects to Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Developmental neurobiology. ; Neuroscience. ; Neurology. ; Development of the Nervous System.
    Description / Table of Contents: The development of the cerebellum: from the beginnings -- Part I: Responsibilities and liabilities -- Chapter2. The embryology and anatomy of the cerebellum -- Chapter 3. Cellular and genetic programs underlying cerebellum development -- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. - Chapter 5. Development of the Fish Cerebellum. -Chapter 6. Cerebellar developmental disorders and cerebellar nuclei -- Chapter 7. Motor circuit abnormalities during cerebellar development -- Chapter8. Developmental disorders of the cerebellum and neurotrophic factors -- Chapter9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development -- Chapter10. The ubiquitin proteasome system and cerebellar developmental disease -- Chapter11. Epigenetics and Cerebellar Neurodevelopmental Disorders -- Chapter12.. Hormonal regulation of cerebellar development and its disorders -- Chapter13. Infections of the Cerebellum -- Chapter14. Neuroimmune mechanisms of cerebellar development and its developmental disorders -- Chapter15. Teratogenic influences on cerebellar development -- Chapter16. Primary pediatric brain tumors of the posterior fossa -- Chapter17. Primary pediatric brain tumors of the posterior fossa -- Chapter18. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa -- Chapter19. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder -- Chapter20. Congenital cerebellar disease -- Chapter21. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders -- Chapter22. Epidemiology of cerebellar disorders -- Chapter23. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum. - Chapter 24. Non-coding RNAs and cerebellar development. - Chapter 25. Defining the Cerebellar Cytoarchitecture Using MRI. .
    Abstract: This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.
    Type of Medium: Online Resource
    Pages: IX, 639 p. 116 illus., 88 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031231049
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-23104-9
    DOI: 10.1007/978-3-031-23104-9
    DDC: 612.8
    Language: English
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    Online Resource
    The Flax Genome (2023)
    Cham :Springer International Publishing :
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    Keywords: Botany. ; Genetics. ; Biotechnology. ; Plant Science. ; Genetics and Genomics. ; Biotechnology.
    Description / Table of Contents: Reference genome sequence of flax -- Repeat DNA sequences in flax genomes -- Pale flax (Linum bienne): an underexplored flax wild relative -- Flax breeding -- QTL mapping: strategy, progress and prospects in flax -- Genetics of abiotic stress in flax. QTL and candidate genes for flax disease resistance -- Key stages of flax bast fiber development through the prism of transcriptomics -- Metabolomics and transcriptomics-based tools for linseed improvement.
    Abstract: The Flax Genome is a comprehensive compilation of most recent studies focused on reference genome, genetic resources and molecular diversity, breeding, QTL mapping, gene editing tools, functional genomics and metabolomics, molecular breeding via genomic selection, and genomic resources. The flax genome reference sequences and the new genome assemblies are presented. A list of flax QTL and candidate genes associated with more than 35 traits, including yield and agronomic, seed quality and fatty acid composition, fibre quality and yield, abiotic stress, and disease resistance traits, are summarized. A QTL- based genomic selection strategy and genome–editing tools are systematically introduced. In addition, huge amounts of flax genomic resources generated in the last decade are summarized. The book contains 13 chapters with about 390 pages authored by globally reputed researchers in the relevant fields to this crop The book is intended to be useful to students, teachers, and researchers interested in traditional and molecular breeding, pathology, molecular genetics and breeding, bioinformatics and computational biology, and functional genomics.
    Type of Medium: Online Resource
    Pages: XII, 294 p. 74 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031160615
    Series Statement: Compendium of Plant Genomes,
    URL: https://doi.org/10.1007/978-3-031-16061-5
    DOI: 10.1007/978-3-031-16061-5
    DDC: 580
    Language: English
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    Online Resource
    Malarial Drug Delivery Systems : Advances in Treatment of Infectious Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Drug delivery systems. ; Nanobiotechnology. ; Pharmaceutical chemistry. ; Tropical medicine. ; Pharmacology. ; Medical microbiology. ; Drug Delivery. ; Nanobiotechnology. ; Pharmaceutics. ; Tropical Medicine. ; Pharmacology. ; Medical Microbiology.
    Description / Table of Contents: Malaria: Cellular Understanding of Disease -- Drug Resistance, Statistics and Patent Status -- Malaria: Current Treatment Options -- Polymeric Nanoparticles in Malaria -- Solid Lipid Nanoparticles in Malaria -- Dendrimers in Malaria -- Liposomes in Malaria -- Micro and Nano Emulsions in Malaria -- Nanosuspension in Malaria -- Alginate and Gelatin Nanoparticles in Malaria -- Niosomes in Malaria -- Metal Nanoparticles in Malaria -- Nanotechnology in Malaria Diagnosis -- Nanotechnology-based Vaccination -- Herbal Platforms in Malaria -- Surface-modified Drug Delivery Systems in Malaria,- Clinical Trials in Malaria -- Malaria-Overall Picture -- New Drugs in Synthesis Research for Malaria -- Disease Models In Malaria Research.
    Abstract: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause of significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at the cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The theme of the first book is Malaria. This book compiles the complete road map of malarial drug delivery systems by understanding the pathophysiology of the disease, the current state of malaria across the globe, new clinical trials, emerging drugs, and the development of novel drug delivery platforms. Various novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of malarial research.
    Type of Medium: Online Resource
    Pages: X, 395 p. 55 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031158483
    URL: https://doi.org/10.1007/978-3-031-15848-3
    DOI: 10.1007/978-3-031-15848-3
    DDC: 615.6
    Language: English
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  • 36
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    Online Resource
    Health and Welfare of Captive Reptiles (2023)
    Cham :Springer International Publishing :
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    Keywords: Veterinary medicine. ; Physiology. ; Animal welfare Moral and ethical aspects. ; Ecology . ; Zoology. ; Veterinary Science. ; Animal Physiology. ; Animal Ethics. ; Ecology. ; Zoology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Physiology and Functional Anatomy -- Chapter 3. Sensory Systems -- Chapter 4. Biology of Stress -- Chapter 5. Normal Behaviour -- Chapter 6. Social Behaviour as a Challenge for Welfare -- Chapter 7. Brains, Behaviour, and Cognition: Multiple Misconceptions -- Chapter 8. Psychological and Behavioural Principles and Problems -- Chapter 9. Effects of Ontogeny, Rearing Conditions, and Individual Differences on Behaviour: Welfare, Conservation, and Invasive Species Implications -- Chapter 10. Controlled Deprivation and Enrichment -- Chapter 11. Effects of Noise and Light -- Chapter 12. Ethologically Informed Design and DEEP Ethology in Theory and Practice -- Chapter 13. Spatial and Thermal Factors -- Chapter 14. Nutritional Considerations -- Chapter 15. Naturalistic Versus Unnaturalistic Environments -- Chapter 16. Evidential Thresholds for Species Suitability in Captivity -- Chapter 17. Record Keeping as an Aid to Captive Care -- Chapter 18. Arbitrary Husbandry Practices and Misconceptions -- Chapter 19. Miscellaneous Factors.
    Abstract: This extensively revised and expanded new edition offers concepts, principles and applied information that relates to the wellbeing of reptiles. As a manual on health and welfare in a similar vein to volumes addressing the sciences of anatomy, behaviour or psychology, this book thoroughly examines the biology of reptile welfare and is about meeting biological needs. The editors, acknowledged experts in their own right, have once again drawn together an extremely impressive international group of contributors. Positive and negative implications of general husbandry and research programs are discussed. In addition to greatly revised original content are nine new chapters offering readers novel insight into: • sensory systems • social behaviour • brain and cognition • controlled deprivation and enrichment • effects of captivity-imposed noise and light disturbance on welfare • spatial and thermal factors • evidential thresholds for species suitability in captivity • record keeping as an aid to captive care • arbitrary husbandry practices and misconceptions The authors have adopted a user-friendly writing style to accommodate a broad readership. Although primarily aimed at academic professionals, this comprehensive volume is fundamentally a biology book that will also inform all involved in captive reptile husbandry. Among others, zoo personnel, herpetologists, veterinarians, lab animal scientists, and expert readers in animal welfare and behavioural studies will benefit from this updated work.
    Type of Medium: Online Resource
    Pages: XI, 638 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783030860127
    URL: https://doi.org/10.1007/978-3-030-86012-7
    DOI: 10.1007/978-3-030-86012-7
    DDC: 636.089
    Language: English
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    Online Resource
    Garden Plants Taxonomy : Volume 2: Angiosperms (Eudicots) (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Plant anatomy. ; Plant physiology. ; Landscape architecture. ; Plant diseases. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Physiology. ; Landscape Architecture. ; Plant Pathology. ; Agriculture.
    Description / Table of Contents: Part-Dicotyledons -- 1. Basal Lineages -- 2. Magnoliids -- 3. Eudicots -- Index.
    Abstract: Horticulture has remained far behind in understanding of botanical principles. Recent phylogenetic (DNA-based) reorganization of higher plants has revolutionized taxonomic treatments of all biological entities, even when morphology does not completely agree with their organization. This book is an example of applying principals of botanical phylogenetic taxonomy to assemble genera, species, and cultivars of 200 vascular plant families of ferns, gymnosperms, and angiosperms that are cultivated for enhancement of human living space; homes, gardens, and parks. The emphases are on cultivated species but examples of some plants are often shown in the wild and in landscapes. In providing descriptions, it is assumed that students and other interested individuals have no background in general botany (plant characteristics), or nomenclature. Fundamental features of all plant groups discussed are fully illustrated by original watercolor drawings or photographs. Discussion of the families is grounded on recent botanical phylogenetic treatments, which is based on common ancestry (monophyly). Of course, phylogenetic taxonomy is not a new concept, and was originally based on morphological characteristics; it is the DNA-based phylogeny that has revolutionized modern biological classifications. In practical terms, this book represents the horticultural treatment that corresponds to phylogenetic-based botanical taxonomy, to which is added cultigens and cultivated genera and species. Hence, the harmony between horticultural and botanical taxonomy. This book covers phylogenetic-based taxonomy of Angiosperms (Eudicots). A companion volume covers Ferns, Gymnosperms, and Angiosperms (Monocots).
    Type of Medium: Online Resource
    Pages: XXXV, 1493 p. 1326 illus., 1325 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115653
    URL: https://doi.org/10.1007/978-3-031-11565-3
    DOI: 10.1007/978-3-031-11565-3
    DDC: 571.32
    Language: English
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    Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    URL: https://doi.org/10.1007/978-3-031-22903-9
    DOI: 10.1007/978-3-031-22903-9
    DDC: 571.978
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    Regulatory Aspects of Gene Therapy and Cell Therapy Products : A Global Perspective (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Medical genetics. ; Genetics. ; Cell Biology. ; Medical Genetics. ; Clinical Genetics. ; Genetics.
    Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .
    Abstract: This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization. This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
    Type of Medium: Online Resource
    Pages: IX, 242 p. 37 illus., 36 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031345678
    Series Statement: Advances in Experimental Medicine and Biology, 1430
    URL: https://doi.org/10.1007/978-3-031-34567-8
    DOI: 10.1007/978-3-031-34567-8
    DDC: 571.6
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  • 40
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    Online Resource
    Tubercular Drug Delivery Systems : Advances in Treatment of Infectious Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Drug delivery systems. ; Diseases. ; Pharmaceutical chemistry. ; Nanomedicine. ; Drug Delivery. ; Diseases. ; Pharmaceutics. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Global health and Tuberculosis past, present and Future -- Tuberculosis: cellular understanding of disease.-Metal nanoparticles in TB -- TB: current treatment options -- Polymeric nanoparticles in TB -- Solid lipid nanoparticles in TB -- Dendrimers in TB -- Liposomes in TB -- Micro, nano emulsions in TB -- Nano suspension in TB -- Alginate, gelatin nanoparticles in TB -- Niosome in TB -- Surface modified drug delivery systems in TB -- Clinical trials in TB -- Herbal platforms in TB.
    Abstract: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the microorganisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious diseases. • Malarial drug delivery systems • Tubercular drug delivery systems • Viral drug delivery systems • Infectious disease drug delivery systems The theme of the second book is Tuberculosis (TB). This book addresses the recent trends in drug delivery for treating TB using new formulation technologies, and the mechanism how it can prevent or delay the drug resistance. It covers current drug therapy and new drug targeting approaches focusing on innovative trend-defining technologies and drug delivery platforms. It is essential to understand the relationship between host pathogens for better treatment. Various novel and nano-formulations using promising technologies are being explored to deliver TB drugs via different administration routes at right pathological site. This book addresses the gap between new and old treatment TB modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of TB research.
    Type of Medium: Online Resource
    Pages: X, 337 p. 51 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031141003
    URL: https://doi.org/10.1007/978-3-031-14100-3
    DOI: 10.1007/978-3-031-14100-3
    DDC: 615.6
    Language: English
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    Online Resource
    Hereditary Gastric and Breast Cancer Syndrome : CDH1: One Genotype with Multiple Phenotypes (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer Genetic aspects. ; Cancer Treatment. ; Cancer. ; Medical screening. ; Oncology. ; Cancer Genetics and Genomics. ; Cancer Therapy. ; Cancer Screening. ; Oncology.
    Description / Table of Contents: Part I. Epidemiology -- Family History and the Risk of Breast and Gastric Cancer -- Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis -- Hereditary Lobular Breast Cancer: A Newly Defined Syndrome -- Part II. Genetics -- Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes -- CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes -- Revisiting the Biological and Clinical Impact of CDH1 Missense Variants -- Other Syndromes and Genes Associated with Gastric Cancer Predisposition -- Computer-Assisted Interpretation of Cancer-Predisposing Variants -- Part III. Pathology -- Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling -- HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations -- Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers -- Part IV. Endoscopy and Imaging -- Endoscopy: Is there Anything New? -- Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families -- Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon -- Part V. Surgery -- Prophylactic Total Gastrectomy: Techniques -- Prophylactic Total Gastrectomy: How Many? -- Hereditary Lobular Breast Cancer Syndrome: Role of Surgery -- Breast Reconstruction -- Part VI. New Issues -- Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis -- Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives -- The Chemoprevention of Hereditary Diffuse Gastric Cancer -- Malformations and Malformative Syndromes Associated with CDH1 -- Hereditary Breast Cancer Non-CDH1 Associated -- Part VII. Patient Advocacy -- My Hereditary Gastric Cancer -- Hereditary Breast Cancer Syndrome, My Experience -- Part VIII. Miscellaneous -- β-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.
    Abstract: In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
    Type of Medium: Online Resource
    Pages: XV, 422 p. 58 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031213175
    URL: https://doi.org/10.1007/978-3-031-21317-5
    DOI: 10.1007/978-3-031-21317-5
    DDC: 576.5
    Language: English
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    Nanotoxicology in Nanobiomedicine (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Toxicology. ; Nanomedicine. ; Nanobiotechnology. ; Toxicology. ; Nanomedicine and Nanotoxicology. ; Medical Toxicology. ; Nanobiotechnology.
    Description / Table of Contents: Introduction -- Terminology -- nano -- polymer nanoparticles -- Nonpolymer nanoparticles -- Nanodevices -- Hybrid materials -- Nanocomposite -- Biomedical -- Further Reading -- Historical Development and Future Trends -- introduction -- Early Period -- Premodern period -- Middle Ages -- Modern Nanotechnology -- Regulations.-Scientific Trends -- Future Trends.-Small Systems Big Applications -- Smart Pills -- Beating the Big C -- Further Reading -- Sources and Classifications -- Introduction -- Properties -- Nanomaterials and Bulk Materials -- Sources -- Naturally produced -- Incidental -- Engineered Nanomaterials.-Classifications -- Natural NPs/NMs -- Incidental NPs -- Synthetic (Engineered) Nanomaterials (NMS) -- Dimensions Based Nanomaterials -- Nanoparticles -- Nanoclays -- nanoemulsions -- Further Reading -- Synthesis, Detection and Characterization -- Introduction -- Production Approaches -- Synthesis -- Physical Methods -- Chemical Methods -- Biological Approach -- magnetic nps -- Hybrid nanomaterials -- nanocomposites.-Detection -- Characterization and isolation -- Direct Techniques -- indirect Techniques -- Key Issues in Fabrication -- Further Reading -- Mechanisms of Nanotoxicty -- introduction -- Entry Sites and Uptake -- Elimination -- Phagocytosis -- Macropinocytosis -- Other Entry Mechanisms -- Intracellular Trafficking -- Trojan Horse Mechanism -- Cellular Exocytosis -- Cellular Dysfunction -- Inorganic Nanomaterial Toxicity -- Cell Deaths -- Further Readings -- Applications-. Introduction -- Nanoparticle-Based Technologies-. Agriculture -- Energy and Environment -- Materials Science and Engineering -- Materials Science and Engineering -- Health and Medicine -- Hybrid Nanomaterials -- Nanocomposites -- Further Reading -- Nano Based Drug Delivery Systems -- Introduction -- Overview in Biomedical Science -- properties of NP Drug Delivery -- Factors influencing Drug Laden Nanocarriers -- pH Specificity -- Temperature Specificity -- Temperature Specificity -- Advantages of Delivery Vehicles -- Nanocarriers -- Passive Targeting -- Active Targeting -- Uses and Applications -- Delivery Vehicles -- Organic Nanomaterials.-Poly-alkyl-cyano-acrylates (PAC) -- Artificial DNA Nanostructures -- Nanocomposites -- Hybrid nanoparticles -- Further Reading.-Tissue Engineering in Dentistry -- Introduction -- Materials for Dental Applications -- Structure and Periodontal Tissue -- Factors Affecting Bone Tissue Regeneration -- Periodontal Diseases -- Tissue Engineering -- Procedure -- Assembly Methods -- Bone Tissue Engineering -- Stem Cell Sources -- Signaling Molecules -- Scaffold/Matrices -- Bioactive Glasses -- Metal-Based materials -- Polymers -- Composites -- Scaffoldfree Techniques -- Biocompatibility -- Drug or Signaling Molecules Delivery -- Future Prospectives -- Further Reading -- Nanobiosensors -- Introduction -- Variations and Types -- Nanoparticle Based Sensors -- Nanotube Based Sensors -- Nanowire Based Sensors -- Components of a typical Biosensors -- Selection and Optimization -- -- Applications -- Cancer -- Detection of diabetes -- Immunoassay (detection of Ab-Ag reaction) -- Detection of pathogenic bacteria -- Future Prospects -- Further Reading -- Health and Medicine -- Introduction -- Keywords -- Nanostructures -- Polymers or Organic NPs -- Nonpoymers or Inorganic Nanoparticles -- Health and Medicine -- Neurodegenerative Disorders -- Tuberculosis -- Ophthalmology -- Respiratory diseases -- Surgery -- Toxicity -- Conclusion -- Further Reading Multiple Choice Questions. .
    Abstract: This book provides that knowledge needed to introduce individuals to the most important research and content on nanotoxicology in nanobiomedicine. Nanotechnology is helping to considerably improve, even revolutionize many technology and industry sectors: information technology, homeland security, medicine, transportation, energy, food safety, and environmental science, among many others. There is an urgent need for a general reference textbook that presents the most recent information on the toxicity and its effects in all these sectors, biomedicine in particular. It includes historical information, nanotoxicology by subject area and or disease, sources of nanomaterials, drug delivery systems and more. Scientists, researchers, and students in all fields that use nanotechnology will find this book essential reading.
    Type of Medium: Online Resource
    Pages: XVII, 179 p. 45 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031242878
    URL: https://doi.org/10.1007/978-3-031-24287-8
    DOI: 10.1007/978-3-031-24287-8
    DDC: 615.90072
    Language: English
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    Online Resource
    New Horizons in Meiobenthos Research : Profiles, Patterns and Potentials (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Invertebrates. ; Biotic communities. ; Biodiversity. ; Applied ecology. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Invertebrate Zoology. ; Ecosystems. ; Biodiversity. ; Applied Ecology. ; Water.
    Description / Table of Contents: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.
    Abstract: Since research on meiobenthos was last compiled in a textbook (2008/2009), the number of theoretical and applied studies has been growing rapidly. Supported by new methods and digital evaluation, meiobenthology has developed into a wide field, with more and more researchers studying cross-disciplinary aspects. New perspectives were summarized in a booklet (2019) to draw attention to promising research directions. The present book, written by leading experts, is a compilation of new thinking, data, methods and approaches in many relevant fields of recent meiobenthos research. The topics addressed range from bacteria and biofilms to globally changing processes, from polar regions to the deep-sea and from freshwater ecosystems to the ocean. So, this book is not simply another meiobenthos textbook - it is an attempt to identify new horizons in meiobenthos research, driven by the vision of advancing knowledge and understanding of benthic ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 407 p. 49 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031216220
    URL: https://doi.org/10.1007/978-3-031-21622-0
    DOI: 10.1007/978-3-031-21622-0
    DDC: 577.6
    Language: English
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    Visceral Pain (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    Description / Table of Contents: Tools for optogenetic probing of nociceptive pathways; Monitoring activity -- An open science model to accelerate the generation, implementation and distribution of optogenetics and viral tools -- Vagal neuroinflammation accompanying respiratory viral infection: An overview of mechanisms and possible clinical significance -- Stress-induced Visceral Analgesia: Concept and Pathways -- Evidence of early life stress exposure and epigenetic modifications in functional chronic pain disorders -- EPIGENETIC REGULATION OF STRESS-INDUCED VISCERAL PAIN -- The biomechanics and mechanotransduction in visceral nociception -- VISCERAL NOCICEPTION IN GASTROINTESTINAL DISEASE -- Epithelial-Neuronal Communication in Visceral Pain -- Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome -- A fentanyl analogue that activates u-opioid receptors in acidified tissues inhibits colitis pain without opioid side effects -- Signalling in the Gut -- Translating colonic sensory afferent peripheral mechanosensitivity into the spinal cord dorsal horn -- Translating colonic afferent peripheral sensitivity into the spinal cord dorsal horn -- Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain -- Pre-clinical Models of Endometriosis -- Spinal afferent innervation of the uterus -- Post-infectious bladder hypersensitivity in the development of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
    Abstract: The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
    Type of Medium: Online Resource
    Pages: VIII, 255 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257025
    URL: https://doi.org/10.1007/978-3-031-25702-5
    DOI: 10.1007/978-3-031-25702-5
    DDC: 612.8
    Language: English
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  • 45
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    Sex Differences in Brain Function and Dysfunction (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: Part 1: Considering sex and gender in research studies -- Sex and Gender Science -- Best practices in the study of sex? -- Best practices in the study of Gender Differences -- The special case of a lack of sex differences – the naked mole rat? -- Lateralization and -- Part 2: Sex differences in cognitive and mental health across the lifespan -- Depression -- Schizophrenia -- Immune and neurodevelopmental disorders – autism? -- Social Cognition -- Cognition and cognitive ageing -- Part 3: Diseases of the brain and relevance of sex -- Epilepsy -- Stroke -- AD -- Parkinson’s -- Multiple Sclerosis.
    Abstract: Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mental health and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.
    Type of Medium: Online Resource
    Pages: X, 373 p. 70 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031267239
    Series Statement: Current Topics in Behavioral Neurosciences, 62
    URL: https://doi.org/10.1007/978-3-031-26723-9
    DOI: 10.1007/978-3-031-26723-9
    DDC: 612.8
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  • 46
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    Trials for Cerebellar Ataxias : From Cellular Models to Human Therapies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-24345-5
    DOI: 10.1007/978-3-031-24345-5
    DDC: 612.8
    Language: English
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    Potency Assays for Advanced Stem Cell Therapy Medicinal Products (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Medical microbiology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Medical Microbiology.
    Description / Table of Contents: The Art of Cell Therapy -- Scope and Applicability of Autologous Cell Therapies -- Scale and Accessibility of Allogeneic Cell Therapies -- Acellular Stem Cell Products. Potency Assays: The Buggy Boo of Stem Cell Therapy -- Potency Assay Development: A Keystone for Clinical Use -- Quantifying Critical Quality Attributes -- Advanced Technologies for Potency Assay Measurement -- Potency Quality by Design: Tailoring for Specific Therapy -- Contract Research Organizations Expediting Therapeutic Availability -- Regulatory Authority Perspectives for Potency Release Criteria -- Illustrative Potency Assay Examples from Approved Therapies -- The Integrity of Potency Assays and Safe Intervention -- The Evolving Landscape of Potency Assays.
    Abstract: This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors from clinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved. Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potency assay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs. —Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology .
    Type of Medium: Online Resource
    Pages: XIX, 214 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031300400
    Series Statement: Advances in Experimental Medicine and Biology, 1420
    URL: https://doi.org/10.1007/978-3-031-30040-0
    DOI: 10.1007/978-3-031-30040-0
    DDC: 571.6
    Language: English
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    The Nature of Living Being : From Distinguishing Distinctions to Ethics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biology Philosophy. ; Philosophy of nature. ; Ontology. ; Philosophy of Biology. ; Philosophy of Nature. ; Ontology.
    Description / Table of Contents: Chapter 1 Distinction-Distinguishing -- Chapter 2 Distinguishing Distinctions -- Chapter 3 ב and the Emergence of Living Being -- Chapter 4 Empirical Evidence for ב -- Chapter 5 Formal Definition of Distinction -- Chapter 6 The Mathematical Ideal and the Elision of the Subject -- Chapter 7 Four Kinds Of Things -- Chapter 8 [Subjects] -- Chapter 9 Living Being -- Chapter 10 The Paradoxical Nature of Aliveness and [Ethics].
    Abstract: This book proposes a bold idea. Living beings are distinguishing distinctions. Single cells and multicellular organisms maintain themselves distinct by drawing distinctions. This is what organisms are and what they do. From this starting point, key issues examined range across ontology, epistemology, phenomenology, logic, and ethics. Topics discussed include the origin of life, the nature and purpose of biology, the relation between life and logic, the nature and limits of formal logic, the nature of subjects, the subject-object relation, subject-subject relationships and the deep roots of ethics. The book provides a radical new foundation to think about philosophy and biology and appeals to researchers and students in these fields. It powerfully debunks mechanical thinking about living beings and shows the vast reservoir of insights into aliveness available in the arts and humanities. .
    Type of Medium: Online Resource
    Pages: XIX, 320 p. 36 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031247897
    Series Statement: Biosemiotics, 26
    URL: https://doi.org/10.1007/978-3-031-24789-7
    DOI: 10.1007/978-3-031-24789-7
    DDC: 570.1
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    Neurobiological and Psychological Aspects of Brain Recovery (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Chapter 1: Understanding the Mechanisms of Dendritic Arbor Development: Integrated Experimental and Computational Approaches -- Chapter 2: Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive -- Chapter 3: Environmental enrichment and functional plasticity in the hippocampus, an update on the mechanisms involved -- Chapter 4: Translatable Models of Brain and Cognitive Reserve -- Chapter 5: Cognitive Reserve: A Life-Course Perspective -- Chapter 6: Neural Correlates of Brain Reserve: A Neuroimaging Perspective -- Chapter 7: Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans -- Chapter 8: Roles of Synaptic Plasticity in Functional Recovery After Brain Injury -- Chapter 9: Integrated Methods of Neuromodulation for Guiding Recovery Following Stroke -- Chapter 10: Resilience in Brain Networks After Stroke -- Chapter 11: Epigenetics and brain plasticity: back to function -- Chapter 12: Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders -- Chapter 13: BRAIN RECOVERY IN CHILDHOOD: THE INTERACTION BETWEEN DEVELOPMENTAL PLASTICITY AND REGENERATIVE MECHANISMS -- Chapter 14: Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury -- Chapter 15: Making Meaning of Acquired Brain Injury: Resources for Functional Recovery -- Chapter 16: An Update on Premorbid Personality Traits and Brain Recovery - Another Aspect of Resilience -- Chapter 17: Psychological Aspects of Recovery After Brain Injury: A Focus on Psychodynamic Factors -- Chapter 18: Artificial Intelligence applications for Traumatic Brain Injury research and clinical management.
    Abstract: The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.
    Type of Medium: Online Resource
    Pages: XXIV, 406 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031249303
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-24930-3
    DOI: 10.1007/978-3-031-24930-3
    DDC: 612.8
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    The Citron Compendium : The Citron (Etrog) Citrus medica L.: Science and Tradition (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Botany. ; Judaism. ; Religion and science. ; Arts. ; Plant Science. ; Judaism. ; Religion and Sciences. ; Arts.
    Description / Table of Contents: The Biology of the Citron -- Citron Genomics -- Citron Phytochemistry -- Selected Aspects of Commercial Production in Etrog Orchards -- Preserving Etrog Quality After Harvest: Doctrine and Practice -- Citron Arthropod Pests in the Mediterranean, Their Origin and Notes On Their Biology and Management -- Diseases of the Etrog Citron and Other Citrus Trees -- The Citron ( Citrus medica L.) in China -- The Citron in Italy and Its cultivation in Calabria -- The Citron in Corsica -- The Citron in the United States -- The Citron in Mediterranean Food and Beverages -- 'Fruit of the Goodly Trees’: The Talmudic Discourse on the Etrog Citron -- From Theophrastus to the Present: The Citron in Medicine -- The Etrog Citron in Art -- The Etrog Citron in Midrashic and Kabbalistic Literature -- From ‘An Etrog’ to ‘One's Etrog’: A Literary Analysis of S.Y. Agnon’s Story -- History of the Citron in Ancient Israel and the Near East -- The Etrog Citron Trail to the North: Genoa and Trieste -- The Corfu Etrog Citron Polemic -- The Grafted Etrog Citron Controversy -- Etrog Citrons of the Land of Israel in Modern Times.
    Abstract: This comprehensive book covers the theoretical and practical aspects of citron trees and fruit. The citron (Citrus medica L.), one of the three primary species ancestral to most citrus types, is used for traditional medicine and is highly revered in the Jewish religion during the Tabernacles feast, referred to by the name 'Etrog'. This book’s three sections address biology (botany, genomics, Chinese and Mediterranean citrons, diseases, pests, and horticulture), tradition (Talmudic discourse, mysticism, medicine, literature, art, food, and beverages) and history (archaeology, trade, grafting controversies); these sections are supplemented by a glossary and pictorial album. The 22 chapters, some new and some translated and considerably expanded from the 2018 Hebrew edition, were written by world-renowned specialists from Israel, Italy, France, the U.S.A., China and Australia. The book is written in an accessible scientific style aimed at a wide range of readers. .
    Type of Medium: Online Resource
    Pages: XVIII, 607 p. 228 illus., 196 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257759
    URL: https://doi.org/10.1007/978-3-031-25775-9
    DOI: 10.1007/978-3-031-25775-9
    DDC: 580
    Language: English
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    Heart Valves : From Design to Clinical Implantation (2023)
    Cham :Springer International Publishing :
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    Keywords: Cardiovascular system. ; Physiology. ; Biomedical engineering. ; Heart Surgery. ; Cardiology. ; Cardiovascular Physiology. ; Biomedical Engineering and Bioengineering. ; Cardiac Surgery. ; Cardiology.
    Description / Table of Contents: ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE. - The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Complex repair of CHD requiring conduits OR valve replacement outside of the ROSS procedure -- VALVE REPAIR AND REPLACEMENT -- Heart valve disease -- History of heart valve repair -- The Ross Procedure -- The Use of Echocardiographic imaging of Valves -- Advanced 3D imaging (CT and MRI) and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Post TAVR PCI -- Complex Procedures in TAV, SAV, HARPOON, BASILICA w/ case studies -- Tissue engineered heart valves -- New trends for valve replacement like the Ozaki procedure -- Post-operative management of valves: On-X valve in post anticoagulation management -- TESTING, REGULATORY and TRAINING ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Virtual Prototyping and 3D Printing For Simulation -- Computational Modeling, Validation, Verification and Uncertainty: Device simulation in Valvular Anatomies -- Procedural Training and Education: Mixed Realities.
    Abstract: This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.
    Type of Medium: Online Resource
    Pages: XVII, 615 p. 252 illus., 206 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031255410
    URL: https://doi.org/10.1007/978-3-031-25541-0
    DOI: 10.1007/978-3-031-25541-0
    DDC: 573.1
    Language: English
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    3D Printing of Sustainable Insect Materials (2023)
    Cham :Springer International Publishing :
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    Keywords: Food science. ; Food security. ; Food Analysis. ; Chemistry. ; Food Science. ; Food Security. ; Food Engineering. ; Food Studies. ; Food Chemistry.
    Description / Table of Contents: Entomophagy in 3D Food Printing -- Entomophagy and its Application through 3D Printing for Sustainable Food Development -- Crickets as a promising alternative edible insect: nutritional and technological aspects and 3D printing prospective -- Insects Nutrition And 3D Printing -- Entomophagy: Application of Edible Insects in 3D Printed Foods -- Edible Insects as Materials for Food Printing: Printability and Nutritional value -- Drosophila as a Potential Functional Food: An Edge over other Edible Insects -- 3D printing, insects and food: a bibliometric analysis -- Inkjet-based 3D food printing for sustainable insect materials: A state-of-the-art review and prospective materials -- Extrusion-based 3D printing concept in customized nutritional products -- A Review on Binder jetting and Selective Laser Sintering: a novel assessment of the processes for 3D Insect food printing materials -- Social, Economic, Scientific and Environment Aspects of Entomophagy in 3D Food Printing.
    Abstract: This book compiles a diverse and interdisciplinary range of scientific literature, laboratory developments, industrial implications and future prospects covering Entomophagy in 3D food printing to fight against hunger and nutritional deficiencies. Recent developments in Entomphagy in 3D printing of Drosophila based materials, and their nutritional, social, economic, scientific and environmental aspects. are comprehensively covered. Readers will also find shortcomings, guidelines, and industrial prospects for these materials, with emphasis on processing methods for the extraction of sustainable materials through 3D food printing. 3D Printing of Sustainable Insect Materials focuses on the methodology, technology and processing used for utilizing insects in 3D food printing applications, establishing technology-driven knowledge to fight against hunger. Chapters cover the principles for Entomophagy, insect processing methods, modern 3D food printing technologies, and the theoretical and practical aspects of Emtomophagy in 3D printing, with a special focus on future prospects and technologies. This ground-breaking book will serve knowledge to researchers and industry professionals across the food industry with broad coverage of emerging technologies, materials developed through Entomophagy, functional characterization and the technical details required to produce sustainable insect-based materials through 3D food printing. .
    Type of Medium: Online Resource
    Pages: VIII, 206 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031259944
    URL: https://doi.org/10.1007/978-3-031-25994-4
    DOI: 10.1007/978-3-031-25994-4
    DDC: 641.3
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    Data Monitoring Committees (DMCs) : Past, Present, and Future (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    URL: https://doi.org/10.1007/978-3-031-28760-2
    DOI: 10.1007/978-3-031-28760-2
    DDC: 615
    Language: English
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    Handbook of Bioethical Decisions. Volume I : Decisions at the Bench (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Medical sciences. ; Drug development. ; Clinical medicine Research. ; Environment. ; Bioethics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Preclinical Research. ; Clinical Research. ; Environmental Sciences.
    Description / Table of Contents: Foreword - Peter Singer -- Introduction: Biomedical Research in One World: Current and Future Challenges -- Part I - Biomedical Research -- Section One - Genetic and Cell Research -- Chap 1: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics -- Chap 2: Bioethical Decision Making and Genome Editing -- Chap 3: Therapeutic Genome Editing -- Chap 4: Bioethical Decision-Making about Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study -- Chap 5: Gene Therapy and Germline Cells Research -- Chap 6: Bioethical Quandaries in Preimplantation Genetic Diagnosis -- Chap 7: Rare Disease Research -- Chap 8: Limits of Debate: Governance of Human Embryo Research and the Making of the Fourteen-Day Rule -- Chap 9 Human/Non-Human Chimeras -- Chap 10: Human Cloning: Recent Advances and Bioethical Issues -- Section Two - Enhancement Research -- Chap 11: The Evolutionary Optimality Challenge -- Chap 12: Mood Enhancement -- Chap 13: Superior Sport Performance: Ethical and Legal Issues -- Chap 14: Arguments over Life Extension in Contemporary Bioethics -- Section Three - Research with Human Biological Samples and Health Data -- Chap 15: Research with Human Biological Samples. Systematization of the Phases and Affected Rights -- Chap 16: Biobanks for Biomedical Research: Evolution and Future -- Chap 17: Biobanking in Global Health & Research -- Chap 18: Ethical and Legal Considerations in Genomic Data Sharing: Evolution of the Discourse and the Road Ahead -- Section Four - Biomedical Challenges in Research -- Chap 19: Human Challenge Trials in Pandemics: Risks and Benefits -- Chap 20: Ethical Considerations for Vaccine Research -- Chap 21: Global Health Partnerships and Emerging Infectious Disease -- Chap 22: Precision Medicine -- Chap 23: The Development, Implementation, and Oversight of Artificial -- Intelligence in Health Care: Legal and Ethical Issues -- Part II - Animals, Food and Environment -- Section One - Using Animals in Scientific Research -- Chap 24: The Use of Animals in Basic Biological Research -- Chap 25: The Use of Animals in the Study of Human Disease: Key Roles of General Ethical Principles -- Chap 26: Ethical Issues Concerning Genetically Modified Animals for the Study of Human Diseases -- Chap 27: Of Mice-Rats and Pig-Men: Ethical Issues in the Development of Human/Nonhuman Chimeras -- Chap 28: Animals in Research in Pharmaceutical Industry -- Chap 29: Animal Use in Toxicity Studies -- Chap 30: Ethical Issues from the Use of Animals in the Cosmetics and Fashion Industries -- Chap 31: Is it Time to Phase Out the Use of all Nonhuman Primates in Invasive Research? -- Chap 32: Growing Human Organs Inside Animals -- Chap 33: Animal Cloning -- Section Two - Decision Making and Alternatives to Animal Use in Research -- Chap 34: Replacement, Reduction and Refinement -- Chap 35: Integrating Human and Nonhuman Research Ethics -- Chap 36: Regulation of Animal Research -- Section Three - GMOs for Global Challenges -- Chap 37: Ethical Issues in Genetically Modified Foods: From Transgenesis to CRISPR-Cas9 Genome Editing Technology -- Chap 38: GMOs and Human and Environmental Safety -- Chap 39: GMOs and Sustainable Agriculture.
    Abstract: The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this work seeks to engender dense ethical epistemology scientists can count on when conducting latest generation biomedical research. By bringing together an impressive array of contributions on the most important elements and categories for “at the bench” bioethical decisions as well as offering chapters by some of the most world renowned and prominent experts in bioethics, the Handbook, Vol. I, is a paradigmatic text in its area and a valuable resource for courses on bioethics, and biomedical research, as well as courses that discuss ethics and the biosciences at different professional levels, biomedical industry, pharmacological companies and the public sphere in general. .
    Type of Medium: Online Resource
    Pages: XX, 778 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294518
    Series Statement: Collaborative Bioethics, 2
    URL: https://doi.org/10.1007/978-3-031-29451-8
    DOI: 10.1007/978-3-031-29451-8
    DDC: 174.2
    Language: English
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    Senescence Back and Forth (2023)
    Cham :Springer International Publishing :
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    Keywords: Aging. ; Medicine Research. ; Biology Research. ; Public health. ; Biotechnology. ; Psychiatry. ; Ageing. ; Biomedical Research. ; Public Health. ; Chemical Bioengineering. ; Psychiatry.
    Description / Table of Contents: Senescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors.
    Abstract: This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
    Type of Medium: Online Resource
    Pages: XXIII, 132 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031322761
    URL: https://doi.org/10.1007/978-3-031-32276-1
    DOI: 10.1007/978-3-031-32276-1
    DDC: 571.878
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    Plant-Based Therapeutics, Volume 1 : Cannabis sativa (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Botany. ; Alternative medicine. ; Pharmacology. ; Medicinal chemistry. ; Physiology. ; Agriculture. ; Plant Science. ; Complementary and Alternative Medicine. ; Pharmacology. ; Medicinal Chemistry. ; Physiology. ; Agriculture.
    Description / Table of Contents: Chapter 1 The History of Cannabis -- Chapter 2 The Bioactive Components of Plants -- Chapter 3 Chemical Constituents of Cannabis -- Chapter 4 The Bioactive Components of Cannabis -- Chapter 5 Neurological Effects of Cannabis -- Chapter 6 Psychotropic Effects of Cannabis -- Chapter 7 The Analgesic effects of Cannabis -- Chapter 8 Cannabis and Perinatal Development -- Chapter 9 Cannabis and Multiple Sclerosis -- Chapter 10 Cannabis and Cancer -- Chapter 11 Cannabis and Parkinson’s disease -- Chapter 12 Cannabis and the Skin -- Chapter 13 Antiviral Activities of Cannabis -- Chapter 14 Alkaline Phosphatase Stimulation.
    Abstract: By examining historical applications of the compounds found in plants, this five-volume series serves as a reference for quality assurance, research, product development, and regulatory guidance of the compounds found in plant-based medicines. This work supports the growing consumers' interest in herbal medicine for wellness and health. Plant-Based Therapeutics, Volume 1: Cannabis sativa, the first in the series, covers a unique plant species and provides the framework to integrate its evidence-based scientific discoveries with healthcare therapies. Cannabis has been used in religious ceremonies and medical purposes for thousands of years. Cannabidiol (CBD), the main non-psychoactive component of Cannabis, was isolated in the 1940s, and its structure was established in the 1960s. In 1964 tetrahydrocannabinol (THC), the psychoactive component, was isolated. Cannabis has more than 500 components, of which 104 cannabinoids have been identified. Two of them, THC and CBD, have been the primary components of scientific investigations. They were approved by the FDA for chemotherapy-induced nausea and vomiting in 1985; for appetite stimulation in wasting conditions, such as AIDS, in 1992, and in 2018 for treating two forms of pediatric epilepsy, Dravet syndrome and Lennox-Gastaut syndrome. Beyond the indications for which cannabinoids are FDA-approved, the evidence reveals that cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system. When cannabinoid receptors are stimulated, a variety of physiologic processes ensue. Thus, other constituents of Cannabis are extremely promising either as individual compounds or their potential synergistic or entourage effects in the treatment of numerous medical conditions. .
    Type of Medium: Online Resource
    Pages: XXI, 657 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031351556
    URL: https://doi.org/10.1007/978-3-031-35155-6
    DOI: 10.1007/978-3-031-35155-6
    DDC: 580
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    Statistical Methods at the Forefront of Biomedical Advances (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biometry. ; Biomedical engineering. ; Bioinformatics. ; Biological models. ; Biostatistics. ; Biomedical Engineering and Bioengineering. ; Computational and Systems Biology. ; Biological Models.
    Description / Table of Contents: Forecasting of SARS-COV-2 dynamic: beyond the classical SIR model -- Derivation of OED methods for applications in cytogenetic biodosimetry -- Minimum Phi-divergence tests for ophthalmological data grouped in clusters -- Multimodality test for determining which genes distinguish oncological patients -- Exploring the relationship between different cancer sites using disease mapping models -- Advances in flow cytometry gating based on distances and divergences in probability spaces -- Application of quantile regression models for biomedical data -- Hippocampus shape analysis via skeletal models and kernel smoothing -- Methods for analysis of microbiome count data with applications -- The FMM model as a classifier of cardiovascular pathologies -- A novel statistical insight of the circadian markers that govern cardiac rhythms -- Sleep and circadian synchronization assessment from multivariate recordings. .
    Abstract: This book presents novel statistics methods and reproducible software that helps to solve challenging problems in biomedicine. Specifically, it consists of a collection of 11 chapters contributed by some of the leading experts in the mathematical and statistical field which address new challenges in very disparate biomedical areas, such as genomics, cancer, circadian biology, microbiome, mental disorders, and more. The mathematical rigor is written in a user-friendly way to serve a general biomedical audience ranging from trainees or students to doctors, as well as scientific researchers, university departments, and PhD students.
    Type of Medium: Online Resource
    Pages: XI, 276 p. 71 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031327292
    URL: https://doi.org/10.1007/978-3-031-32729-2
    DOI: 10.1007/978-3-031-32729-2
    DDC: 570.15195
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    Psammic Peinobiomes : Nutrient-Limited Ecosystems of the Upper Orinoco and Rio Negro Basins (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotic communities. ; Soil science. ; Plant ecology. ; Geomorphology. ; Ecophysiology. ; Conservation biology. ; Ecology . ; Ecosystems. ; Soil Science. ; Plant Ecology. ; Geomorphology. ; Ecophysiology. ; Conservation Biology.
    Description / Table of Contents: 1 Introduction -- Part I: Forest and woodland biomes -- 2 White sand ecosystems in the Amazon basin: geographic distribution, distinctive features, and ecology. An overview -- 3 The forests of the Rio Negro basin in the north-western Amazon: a phytosociological classification -- 4 Amazon caatinga complex: sclerophyllous vegetation on nutrient-poor white sand soils -- Part II: Meadow biomes -- 5 Mapping white-sand ecosystems by integrating Global PALSAR-2 and SENTINEL-1 with NDVI (LANDSAT data) -- 6 The study areas: landscapes and soils -- 7 Soil properties, formation, distribution, and classification -- 8 Origin and sources of sand: from highlands to lowlands -- 9 Sand dynamics and distribution: a geo-sedimentological approach -- 10 Features and trends of meadow landscape evolution -- 11 Meadow phytodiversity: flora, endemism, vegetation types, and geographic distribution patterns -- 12 Synthesis: white-sand and meadow-vegetation relationships.
    Abstract: The book represents a multidisciplinary approach to understanding soil–landscape–vegetation relationships and, specifically, the ecophysiology of plant communities developing on sandy soils of very low fertility that are subject to seasonal flooding. It provides an overview of the white sand ecosystems within the Amazon basin, and focuses on the forest and herbaceous (meadows) vegetation growing on the dystrophic sandy soils of the upper Negro and Orinoco river basins. Several chapters describe physiographic aspects of the study area using integrated remote sensing and in situ sampling. By doing so they attain a comprehensive description of the origin and evolution of soils and landscapes, an advanced classification of soils, and a mapping of the geographic distribution of psammophilous vegetation. This volume also provides a phytosociological classification of extensive forested areas, and a detailed description of the structure and diversity of little-known herbaceous formations. It targets professionals in the fields of ecology, ecophysiology, geomorphology, soils, vegetation, and the environmental sciences. The information it offers may be of significant use to researchers, protected area planners, and environmental policy makers.
    Type of Medium: Online Resource
    Pages: XIV, 541 p. 136 illus., 122 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031207990
    Series Statement: Ecological Studies, Analysis and Synthesis, 247
    URL: https://doi.org/10.1007/978-3-031-20799-0
    DOI: 10.1007/978-3-031-20799-0
    DDC: 577
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    The Almond Tree Genome (2023)
    Cham :Springer International Publishing :
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    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Almond genome analysis and breeding -- Labelling Almond Genome: SAM, QTLs and Association mapping -- Identification of natural variation in almond target genes -- Recent advances on almond bitterness expression at genomic and trascriptomic level -- Recent advances on flower self-incompatibility expression at genomic and transcriptomic level -- Molecular basis of abiotic and biotic stresses in almond -- Genomics for fruit quality traits in almond: QTLs vs Association mapping -- Transcriptional changes associated with flower bud dormancy in almond and other Prunus species: DNA sequence motifs, mRNA and miRNA expression, transcription factors, chromatin modifications and phytohormone signaling -- Almond transcriptome analysis using high-throughput sequencing technologies -- Almond miRNA expression and horticultural implications.
    Abstract: This book brings together the latest information on almond genomics and transcriptomics, with a particular focus on cutting-edge findings, tools, and strategies employed in genome sequencing and analysis with regard to the most important agronomic traits. Cultivated almond [(Prunus dulcis (Miller) D. A. Webb, syn. Prunus amygdalus Batsch., Amygdalus communis L., Amygdalus dulcis Mill.)] is a tree crop producing seeds of great economic interest, and adapted to hot and dry climates. Domesticated in Southeast Asia, its small diploid genome and phenotypic diversity make it an ideal model to complement genomics studies on peach, generally considered to be the reference Prunus species. Both represent consanguineous species that evolved in two distinct environments: warmer and more humid in the case of peach, and colder and xerophytic for almond. The advent of affordable whole-genome sequencing, in combination with existing Prunus functional genomics data, has now made it possible to leverage the novel diversity found in almond, providing an unmatched resource for the genetic improvement of this species.
    Type of Medium: Online Resource
    Pages: XVIII, 171 p. 33 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030303020
    Series Statement: Compendium of Plant Genomes,
    URL: https://doi.org/10.1007/978-3-030-30302-0
    DOI: 10.1007/978-3-030-30302-0
    DDC: 581.35
    Language: English
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    Computerized Systems for Diagnosis and Treatment of COVID-19 (2023)
    Cham :Springer International Publishing :
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    Keywords: Biomedical engineering. ; Therapeutics. ; Diagnosis. ; Diseases. ; Biophysics. ; Biomedical Engineering and Bioengineering. ; Therapeutics. ; Diagnosis. ; Diseases. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Clinical impact of automatic diagnostic systems -- Lung segmentation from XRay -- Lung segmentation from CT Scan -- Covid Automatic Diagnostic based on XRay -- Covid Automatic Diagnostic based on CTScan -- Cardiovascular analysis of covid patients based on ECG -- Cognitive analysis of covid patients based on EEG -- AI Controlled Mechanical Ventilator for COVID-19 patients.
    Abstract: This book describes the application of signal and image processing technologies, artificial intelligence, and machine learning techniques to support Covid-19 diagnosis and treatment. The book focuses on two main applications: critical diagnosis requiring high precision and speed, and treatment of symptoms, including those affecting the cardiovascular and neurological systems. The areas discussed in this book range from signal processing, time series analysis, and image segmentation to detection and classification. Technical approaches include deep learning, transfer learning, transformers, AutoML, and other machine learning techniques that can be considered not only for Covid-19 issues but also for different medical applications, with slight adjustments to the problem under study. The Covid-19 pandemic has impacted the entire world and changed how societies and individuals interact. Due to the high infection and mortality rates, and the multiple consequences of the virus infection in the human body, the challenges were vast and enormous. These necessitated the integration of different disciplines to address the problems. As a global response, researchers across academia and industry made several developments to provide computational solutions to support epidemiologic, managerial, and health/medical decisions. To that end, this book provides state-of-the-art information on the most advanced solutions.
    Type of Medium: Online Resource
    Pages: VI, 209 p. 91 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031307881
    URL: https://doi.org/10.1007/978-3-031-30788-1
    DOI: 10.1007/978-3-031-30788-1
    DDC: 610.28
    Language: English
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    Baobab : The Hadza of Tanzania and the Baobab as Humanity's Tree of Life (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Plant anatomy. ; Plant ecology. ; Plants Development. ; Plant physiology. ; Evolution (Biology). ; Anthropology. ; Plant Anatomy and Morphology. ; Plant Ecology. ; Plant Development. ; Plant Physiology. ; Evolutionary Biology. ; Anthropology.
    Description / Table of Contents: Part I: THE BAOBAB -- Chapter 1. The distinguishing features of the tree of life and the baobab -- Chapter. 2. The Hadza and studies that document their use of the baobab -- Part II: THEORETICAL FRAMEWORK -- Chapter. 3. Hominin adaptation as the development of a gendered forager division of labor -- Chapter. 4. Correlated handiness and bipedality as the outcome of the multidimensional selective pressures of the forager way of life -- Part III: MATERIAL CULTURE AND TECHNOLOGY -- Chapter. 5. Africa’s premier fiber tree -- Chapter. 6. The baobab and container -- Chapter. 7. The baobab and fire in hominin evolution -- Part IV: ENVIRONMENTAL CONSIDERATIONS -- Chapter. 8. The baobab and Hadza acquisition, management and use of water -- Chapter. 9. Baobab seasonality -- PART V: BAOBAB RESOURCES: FOOD, HEALTH, AND EXCHANGE BENEFITS -- Chapter. 10. The Hadza preeminent fruit tree -- Chapter. 11. Baobab beverages -- Chapter. 12. Africa’s honey tree -- Chapter. 13. The baobab and birds -- Chapter. 14. The Hadza diet and the baobab as a source of other animal foods -- Chapter. 15. The baobab as a hunger-time tree of life -- Chapter. 16. The baobab and health -- Chapter. 17. The baobab and exchange -- Part VI: THE INSPIRATIONAL VALUE OF THE BAOBAB -- Chapter. 18. The baobab in Hadza inspirational life -- Chapter. 19. The baobab as a fertility tree -- Chapter. 20. Other inspirational uses of the baobab -- Chapter. 21. The baobab and danger -- Chapter. 22. The baobab and death -- Part VII. THE HADZA AND BAOBAB REGENERATION -- Chapter. 23. The baobab and Hadza central-place residential camps -- Chapter. 24. Hadza influence on baobab regeneration -- Chapter. 25. The Hadza baobab retreat -- Literature cited -- Index. .
    Abstract: Modern humans, descendants of a founding population that separated from chimpanzees some five to eight million years ago, are today the only living representative of a branching group of African apes called hominins. Because of its extraordinary size and shape, the baobab (Adansonia digitata L.) has long been identified as the most striking tree of Africa’s mosaic savanna, the landscape generally regarded as the environment of hominin evolution. This book makes the case for identifying the baobab as the tree of life in the hunter-gatherer adaptation that was the economic foundation of hominin evolution. The argument is based on the significance of the baobab as a resource-rich environment for the Hadza of northeastern Tanzania, who continue to be successful hunter-gatherers of the African savanna.
    Type of Medium: Online Resource
    Pages: XXIX, 382 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031264702
    URL: https://doi.org/10.1007/978-3-031-26470-2
    DOI: 10.1007/978-3-031-26470-2
    DDC: 571.32
    Language: English
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    Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biochemical markers. ; Proteins. ; Metabolism. ; Genomics. ; Biomarkers. ; Proteins. ; Metabolism. ; Genomics.
    Description / Table of Contents: Chapter 1. The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology and Variants of Concern -- Chapter 2. Long-term Vaccination and Treatment Strategies for COVID-19 Disease and Future Coronavirus Pandemics -- Chapter 3. Consequences of the Lockdown - Domestic Violence during the COVID-19 Pandemic -- Chapter 4. Psychological distress impact of Coronavirus disease (COVID-19) outbreak on three continents: A systematic review and meta-analysis -- Chapter 5. A Molecular Biomarker-based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms -- Chapter 6. Genetic Associations with Coronavirus Susceptibility and Disease Severity -- Chapter 7. COVID Diagnostics: from Molecules to Omics -- Chapter 8. Assessing Biomarkers in Viral Infection -- Chapter 9. Proteomic Investigation of COVID-19 Severity During the Tsunamis Second Wave in Mumbai -- Chapter 10. NMR-Metabolomics in COVID-19 Research -- Chapter 11. Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection -- Chapter 12. Red Cell Distribution Width as a Prognostic Indicator for Mortality and ICU Admission in Patients with COVID-19 -- Chapter 13. Predicting the COVID-19 Patients Status using Chest CT Scan Findings: A Risk Assessment Model Based on Decision Tree Analysis -- Chapter 14. Inferring Recombination Events in SARS-CoV-2 Variants In Silico -- Chapter 15. Amplicon-based Nanopore Sequencing of Patients Infected by the SARS-CoV-2 Omicron (B.1.1.529) Variant in India -- Chapter 16. Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics -- Chapter 17. Machine Learning and COVID-19: Lessons from SARS-CoV-2 -- Chapter 18. The Relationship between Psoriasis, COVID-19 Infection and Vaccination during Treatment of Patients -- Chapter 19. Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study -- Chapter 20. Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective -- Chapter 21. Antiviral Mechanisms of Curcumin and its Derivatives in Prevention and Treatment of COVID-19: A review -- Chapter 22. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial -- Chapter 23. Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach -- Chapter 24. The Potential Effect of Royal Jelly on Biomarkers Related to COVID-19 Infection and Severe Progression -- Chapter 25. Statins: Beneficial Effects in Treatment of COVID-19 -- Chapter 26. Multiplex Immunoassay Approaches Using Luminex® xMAP® Technology for the Study of COVID-19 Disease -- Chapter 27. Rapid Detection of SARS-CoV-2 Variants of Concern by Genomic Surveillance Techniques.
    Abstract: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.
    Type of Medium: Online Resource
    Pages: XI, 513 p. 87 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031280122
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1412
    URL: https://doi.org/10.1007/978-3-031-28012-2
    DOI: 10.1007/978-3-031-28012-2
    DDC: 610.72
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    Handbook of Bioethical Decisions. Volume II : Scientific Integrity and Institutional Ethics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Science Moral and ethical aspects. ; Normativity (Ethics). ; Bioethics. ; Biomedical Research. ; Science Ethics. ; Normative Ethics.
    Description / Table of Contents: Foreword: On Handbooks -- Introduction -- Scientific Integrity and Institutional Ethics: Challenges and Perspectives -- Part I - Research Ethics -- Section One - Scientific Integrity and Research Misconduct -- Chap 1: Data Alteration -- Chap 2: Research Misconduct and Questionable Research Practices -- Chap 3: Ethics of Authorship -- Chap 4: Dissemination of Research Results -- Chap 5: Conflicts of Interest in Research -- Chap 6: A Priori Publication Agreements to Improve Adherence to Ethics in Research Publications -- Section Two - Conducting Ethical Research -- Chap 7: Freedom of Scientific Research and Primacy of Human Being: Practical and Epistemological Tensions -- Chap 8: Exploitation in Biomedical Research -- Chap 9: Selection of Research Subjects: Methodological and Ethical Issues -- Chap 10: Confidentiality and Privacy in Digital Clinical Trials -- Chap 11: Dematerialization and Intellectual Property in the Biosciences -- Part II - Institutional Ethics and Bioethics Committees -- Section One - Institutional Ethics -- Chap 12: Historical Development of Institutional Ethics and Bioethics -- Chap 13: Principles of Institutional Ethics -- Chap 14: Institutional Review Boards (IRB): US Perspectives -- Chap 15: Decision Making within Institutions -- Chap 16: Scientific Advances, Ethical Oversight and Legal Institutionality -- Section Two - Ethics and Bioethics Committees -- Chap 17: Members and Structure of Institutional Bioethics Committees -- Chap 18: Foundations of Bioethical Decision-Making in Bioethics and Biolaw -- Chap 19: Just Doing Bioethics': Policy, Principle, and Process -- Chap 20: Ethics Education and Institutional Ethics Committees -- Chap 21: Role of Ethics Committees in Emergency Use of Unproven Interventions Outside Research -- Chap 22: The Ethics of Resource Allocation in Pandemics: A Bayesian Model -- Section Three - Bioethical Issues in Institutional Ethics -- Chap 23: Scientific Knowledge and Social Responsibility -- Chap 24: Conscientious Objection -- Chap 25: Institutional Liability in Research -- Chap 26: Research Assessments Should Recognize Responsible Research Practices. Narrative Review of a Lively Debate and Promising Developments -- Chap 27: Coercion in Mental Health Treatment.
    Abstract: The Handbook of Bioethical Decisions Volume II addresses and analyzes the most important ethical concerns and moral quandaries related to scientific integrity and institutional ethics. It counts on two parts, Part One: Research Ethics, which addresses issues related to Scientific Integrity, Research Misconduct and Conducting Ethical Research, and Part Two: Institutional Ethics and Bioethics Committees, which explores Institutional Ethics issues, Ethics and Bioethics Committees’ roles and scopes, and Bioethical Issues in Institutional Ethics. Consequently, the Handbook, Vol. II, offers a remarkable collection of works by outstanding international experts on institutional and research ethics, in order for bioethics practitioners to obtain better elements to address key issues related to integrity in research as well as to decision-making processes. In this fashion, this volume is a valuable resource for professionals working on different bioethical and biomedical fields, such as, ethics and bioethics committees, health care institutions, biomedical and pharmacological companies, and academic settings, among others. Chapter 26 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 487 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294556
    Series Statement: Collaborative Bioethics, 3
    URL: https://doi.org/10.1007/978-3-031-29455-6
    DOI: 10.1007/978-3-031-29455-6
    DDC: 174.2
    Language: English
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    Trending Topics in Escherichia coli Research : The Latin American Perspective (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Bacteria. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Immunology. ; Food Safety measures. ; Therapeutics. ; Bacteria. ; Medical Microbiology. ; Biomedical Research. ; Immunology. ; Food Safety. ; Therapeutics.
    Description / Table of Contents: Chapter 1. WHO Critical Priority Escherichia coli in Latin America: A One Health Challenge for a PostPandemic World -- Chapter 2. Recent progress on enterotoxigenic E. coli (ETEC) and antibiotic resistance in pathogenic E. coli -- Chapter 3. New concepts on domestic and wild reservoirs, and transmission of E. coli and its environment -- Chapter 4. New molecular mechanisms of virulence and pathogenesis in E. coli.-Chapter 5. Bovine reservoir of STEC and EPEC: advances and new contributions -- Chapter 6. Phages and Escherichia coli -- Chapter 7. Insights into animal carriage and pathogen surveillance in Latin America: the case of STEC and APEC -- Chapter 8. Shiga Toxin and its effect on the Central Nervous System -- Chapter 9. Relevance of Escherichia coli in fresh produce safety -- Chapter 10. Quantitative Microbial Risk Assessment of Hemolytic Uremic Syndrome due to Beef Consumption: Impact of Interventions to Reduce the Presence of Shiga Toxin-Producing Escherichia coli -- Chapter 11. An Updated Overview on the Resistance and Virulence of UPEC -- Chapter 12. Interactions of pathogenic Escherichia coli with gut microbiota -- Chapter 13. Emergence of Hybrid Escherichia coli Strains -- Chapter 14. Genomic analysis of pathogenic E. coli strains in Latin America -- Chapter 15. Therapeutic options for diarrheagenic Escherichia coli.
    Abstract: Latin America has been at the forefront in combating infections caused by Escherichia coli strains in humans, animals, and the environment. The continuous emergence and evolution of pathogenic E. coli strains associated with human and animal infections have demonstrated that (i) groups of related pathogenic E. coli are responsible for most infections caused by this bacterial species; (ii) diverse virulence phenotypes expressed during infection defined each one of these pathogroups; (iii) the geographical distribution of pathogroups in Latin America and the evolution of new isolates was defined by the dominant pathogroup and presence of distinct virulence strains; (iv) acquisition of mobile elements or accumulation of point mutations accelerate the development of antibiotic resistance in some of these strains. The Latin American Coalition for Escherichia coli Research (LACER), a multidisciplinary network of over seventy research groups in eleven Latin American countries and the USA, was established in 2009 to apply One Health principles in defining and combating this pathogen. The previous edition of this text, Escherichia coli in the Americas was the culmination of the investigators' wisdom about E. coli, from its role as a commensal bacterium to its characteristics as a pathogen. This new edition introduces recent advances and contextualizes all aspects of E. coli in a One Health perspective, from the environment, to animals, to humans. It addresses E. coli interactions with host microbiota, CNS, and phages, and includes cutting edge insights on hybrid strains, molecular mechanisms of virulence and pathogenesis, domestic and wild reservoirs, disease surveillance in Latin America, food safety, and new therapies. Crucially, it also presents translations and analysis of key reports on Escherichia coli published in Spanish and Portuguese. This book serves as a critical resource for scientists in industry and academia, clinicians managing associated infections, and trainees and students studying basic and clinical aspects of E. coli pathogenesis. .
    Type of Medium: Online Resource
    Pages: XX, 363 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031298820
    URL: https://doi.org/10.1007/978-3-031-29882-0
    DOI: 10.1007/978-3-031-29882-0
    DDC: 579.3
    Language: English
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    Exogenous Enzymes as Feed Additives in Ruminants (2023)
    Cham :Springer International Publishing :
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    Keywords: Animal culture. ; Physiology. ; Veterinary medicine. ; Animal Science. ; Animal Physiology. ; Veterinary Science.
    Description / Table of Contents: Chapter. 1. Yeast as a source of exogenous enzymes in feeding ruminants -- Chapter. 2. Yeast culture and direct-fed microbes: Modes of action and beneficial applications in ruminants -- Chapter. 3. Effects of Exogenous Enzymes on the Nutritive value of some Fibrous Forage in Ruminants -- Chapter. 4. Exogenous fibrolytic enzymes: for the better utilization of Guinea grass and rice straw as ruminant feeds -- Chapter. 5. Role of Exogenous Enzymes in Feed Digestibility and Reducing the Emission Intensity of Enteric Methane Production in Ruminants -- Chapter. 6. Inclusion of exogenous fibrolytic enzymes in the diets of dairy cows and ewes: Effect on milk yield and milk composition -- Chapter. 7. Determining the Effect Enzyme Addition to Locally Available Forages in Mongolia Using In Vitro and In Vivo Techniques -- Chapter. 8. Fungi as a source of exogenous enzymes to feed ruminants -- Chapter. 9. Dietary inclusion of exogenous fibrolytic enzyme in southern China to enhance fibrous feed utilization by goats and cattle.
    Abstract: This book addresses a global issue of increasing high quality food from ruminant animals while reducing their impacts on the environment. However, one of the main constraints to livestock development and the underlying cause of the low productivity in many developing countries is inadequate nutrition associated with inefficient utilization of forages and fibrous feed resources. In many countries, fibrous feed makes up the bulk of available feed resource base, which is characterized by scarcity and fluctuating supply in the quantity and quality of feed resources, nutrient imbalance as seen in many native pastures, grasslands and crop residues-based feeding systems with limited use of commercial concentrate feeds such as soybean, cottonseed and groundnut meals, etc. Furthermore, the production of methane, an important greenhouse gas (GHG), from ruminants fed highly fibrous diets such as straws and stover is higher than those animals fed better quality forages or concentrate diets. Recent research shows that supplementing livestock diets with exogenous fibre degrading enzymes can improve feed utilization by enhancing intake, fibre degradation in the rumen and overall digestibility of fibrous feeds which in turn leads to improved animal performance, farmers’ income, and a reduction in GHG emissions. The book editors would like to acknowledge the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture for funding part of the studies that make up some of these chapters and were part of the final reports of a coordinated research project financed by IAEA.
    Type of Medium: Online Resource
    Pages: VIII, 195 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031279935
    URL: https://doi.org/10.1007/978-3-031-27993-5
    DOI: 10.1007/978-3-031-27993-5
    DDC: 636
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    Transforming Biocities : Designing Urban Spaces Inspired by Nature (2023)
    Cham :Springer International Publishing :
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    Keywords: Urban ecology (Biology). ; Sustainable architecture. ; Biodiversity. ; Forestry. ; Urban Ecology. ; Sustainable Architecture/Green Buildings. ; Biodiversity. ; Forestry.
    Description / Table of Contents: Towards the Development of a Conceptual Framework of BioCities -- Urban sustainable futures: concepts and policies leading to BioCities -- Biodiversity and Ecosystem Functions as Pillars of BioCities -- Green Infrastructure and Urban Forests for BioCities: Strategic and Adaptive Management -- Mitigation and Adaptation for Climate Change: The Role of BioCities and Nature Based Solutions -- BioCities as Promotors of Health and Wellbeing -- Forests, Forest Products and Services to Activate a Circular Bioeconomy for City Transformation -- Innovative Design, Materials, and Construction Models for BioCities -- The Social Environment of BioCities -- From BioCities to BioRegions and Back: Transforming Urban-Rural Relationships -- The Enabling Environment for BioCities -- Towards BioCities – The Pathway to Transition.
    Abstract: This edited volume centers around the concept of BioCities, which aim to unify nature and urban spaces in order to reverse the effects of global climate change and inequity. Following this principle, the authors propose multiple approaches for sustainable city growth. The discussed concepts are not only relevant for newly constructed cities, but offer transformative perspectives for existing settlements as well. Placing nature at the forefront of city planning is not an entirely new concept, so the authors build on established ideas like the garden city, green city, eco-city, or smart city. All chapters aim to highlight aspects to develop a city that is a resilient nature-based socio-ecological system. Many of these concepts were formed in an effort to copy the best traits of a forest ecosystem: a home for many different species that build complex communities. Much like many of our forests, urban areas are managed by humans for multifunctional purposes, using living and abiotic components. This viewpoint helps to understand the potential and limitations of sustainable growth. With these chapters, the authors want to inspire planners, ecologists, urban foresters and decision makers of the future.
    Type of Medium: Online Resource
    Pages: X, 304 p. 59 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294662
    Series Statement: Future City, 20
    URL: https://doi.org/10.1007/978-3-031-29466-2
    DOI: 10.1007/978-3-031-29466-2
    DDC: 577.56
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    Advances in Maternal-Fetal Biomedicine : Cellular and Molecular Mechanisms of Pregnancy Pathologies (2023)
    Cham :Springer International Publishing :
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    Keywords: Human physiology. ; Reproductive health. ; Reproduction. ; Physiology. ; Pharmacology. ; Cytology. ; Gynecology . ; Human Physiology. ; Reproductive Medicine. ; Reproductive Physiology. ; Pharmacology. ; Cell Biology. ; Gynecology.
    Description / Table of Contents: Feto-Placental Unit: from development to function -- Role of hormones during gestation and early development: pathways involved in developmental programming -- Physiological and pathophysiological role of large-conductance calcium-activated potassium channels (BKCa) in HUVECs and placenta -- Metabolic interaction between Folate, Vitamin B12 and Polyunsaturated Fatty Acids in pregnancy -- Evidence of nitric oxide impairment during hypertensive pregnancies -- Pathophysiology of preeclampsia and L-Arginine/L-citrulline supplementation as a potential strategy to improve birth outcomes -- Maternal and fetal expression of ATP-binding cassette and Solute Carrier transporters involved in the brain disposition of drugs -- Development of the placenta and brain are affected by selective serotonin reuptake inhibitors exposure during critical periods -- The endocannabinoid system in placenta and respiratory central nervous system development: effects of prenatal exposure to cannabinoids -- Impact of prenatal nicotine exposure on placental function and respiratory neural network development -- Language impairment in children of mothers with gestational diabetes, preeclampsia, and preterm delivery: current hypothesis and potential underlying mechanisms -- COVID-19 on pregnancy outcomes, mental health and placenta: focus in Latin America -- The placental function beyond pregnancy: Insights from Latin America.
    Abstract: This textbook aims to describe physiological and pathophysiological mechanisms that underlie human maternal-fetal interactions. The book emphasizes the structure and development of the fetoplacental unit, the endocrine and nutritional regulation of fetal development, nitric oxide signalling, solute carriers function and ion channels regulation in healthy pregnancies and diseases, like preeclampsia, gestational diabetes, and maternal obesity, among others. Also, we highlight novel mechanisms associated with language impairment in children, the use of serotonin inhibitors or cannabis during pregnancy, and maternal conditions' potential impact on cerebrovascular development in newborns and infants. The cellular and molecular understanding of maternal-fetal physiology and pathophysiology will allow the readers to understand the impact of diseases or conditions that are highly prevalent in pregnant women.
    Type of Medium: Online Resource
    Pages: XI, 310 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325540
    Series Statement: Advances in Experimental Medicine and Biology, 1428
    URL: https://doi.org/10.1007/978-3-031-32554-0
    DOI: 10.1007/978-3-031-32554-0
    DDC: 612
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    Imaging Inflammation (2023)
    Cham :Springer International Publishing :
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    Keywords: Radiology. ; Pathology. ; Immunology. ; Radiology. ; Pathology. ; Immunology.
    Description / Table of Contents: Chapter 1. Imaging Inflammation: A Historical Perspective -- Chapter 2. Nuclear Imaging of Inflammation -- Chapter 3. Magnetic Resonance Imaging of Inflammation -- Chapter 4. Ultrasound Imaging in Inflammation Research -- Chapter 5. Whole-body Chemiluminescence and Fluorescence Imaging of Inflammation -- Chapter 6. Photoacoustic Imaging in Inflammation Research -- Chapter 7. Imaging Inflammation by Intravital Microscopy -- Chapter 8. Spatial Transcriptomics in Inflammation: Dissecting the Immune Response in 3D in Complex Tissues.
    Abstract: Imaging Inflammation provides updates on cutting-edge imaging methods being applied to problems in inflammation research. From state-of-the-art research tools to diagnostic tests, and from single-cell to whole-body imaging, this volume offers a comprehensive overview of how imaging experts across a range of disciplines are expanding our understanding of inflammation and immunity.
    Type of Medium: Online Resource
    Pages: XV, 279 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031236617
    Series Statement: Progress in Inflammation Research, 91
    URL: https://doi.org/10.1007/978-3-031-23661-7
    DOI: 10.1007/978-3-031-23661-7
    DDC: 616.0757
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    Cancer Neuroscience (2023)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    URL: https://doi.org/10.1007/978-3-031-32429-1
    DOI: 10.1007/978-3-031-32429-1
    DDC: 571.978
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    Introduction to Mathematics for Computational Biology (2023)
    Cham :Springer International Publishing :
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    Keywords: Bioinformatics. ; Biomathematics. ; Biochemistry. ; Biology Technique. ; Biophysics. ; Computational and Systems Biology. ; Mathematical and Computational Biology. ; Bioinformatics. ; Biochemistry. ; Biophysical Methods.
    Description / Table of Contents: 1. Introduction to graph theory -- 2. Biological networks -- 3. Network inference for drug discovery- 4. Introduction to differential and integral calculus -- 5. Modelling chemical reactions -- 6. Reaction-diffusion systems -- 7. Linear algebra background -- 8. Regression -- 9. Cardiac electrophysiology -- .
    Abstract: This introductory guide provides a thorough explanation of the mathematics and algorithms used in standard data analysis techniques within systems biology, biochemistry, and biophysics. Each part of the book covers the mathematical background and practical applications of a given technique. Readers will gain an understanding of the mathematical and algorithmic steps needed to use these software tools appropriately and effectively, as well how to assess their specific circumstance and choose the optimal method and technology. Ideal for students planning for a career in research, early-career researchers, and established scientists undertaking interdiscplinary research. .
    Type of Medium: Online Resource
    Pages: X, 264 p. 40 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031365669
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-031-36566-9
    DOI: 10.1007/978-3-031-36566-9
    DDC: 570.285
    Language: English
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    Field Environmental Philosophy : Education for Biocultural Conservation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Conservation biology. ; Ecology . ; Environmental education. ; Cultural property. ; Philosophy. ; Conservation Biology. ; Environmental and Sustainability Education. ; Cultural Heritage. ; Ecology. ; Philosophy.
    Description / Table of Contents: Chapter 1. Introduction to Field Environmental Philosophy: A New Methodological Approach for Biocultural Education and Conservation -- Part I: FIELD ENVIRONMENTAL PHILOSOPHY: CONCEPTS AND CASE STUDIES -- Chapter 2. Introduction Part I. Field Environmental Philosophy: Concepts and Case Studies -- Chapter 3. The Multiple Lenses of Ecotourism with a Hand-Lens: Fundamental Concepts and Practices -- Chapter 4. Underwater with a Hand Lens: Ecological Sciences and Environmental Ethics to Value Freshwater Biodiversity -- Chapter 5. Sub-Antarctic High Andean “Gardeners:” Cultivating Caring Relationships -- Chapter 6. “Pay attention, dive with eyes wide open:” a Field Environmental Philosophy activity to foster reciprocity between people and nature -- Chapter 7. The Eyes of The Tree: Applying Field Environmental Philosophy to Tackle Conservation Problems at Long Term Socio-Ecological Research Sites -- Chapter 8. Starfishes and Sky Stars: Field Environmental Philosophy Education and Ecotourism Experiences in Baja California, México -- Chapter 9. Biocitizen’s Approach to Biotic Wonder, Citizenship, and Field Environmental Philosophy -- Chapter 10. Inter-species and Inter-cultural Encounters: The Education and Biocultural Ethics Program of the Omora Ethnobotanical Park -- Chapter 11. Beyond Field Environmental Philosophy: Integrating Science Education and Technology -- Part II: EDUCATION “ON THE RAZOR’S EDGE” -- Chapter 12. Introduction Part II. Education “On the Razor’s Edge” -- Chapter 13. Liberation Philosophy and Biocultural Education. A Latin American Journey -- Chapter 14. Collaborative Action Research for Biocultural Heritage Conservation -- Chapter 15. Education as a Driver of Extinction of Experience or Conservation of Biocultural Heritage -- Chapter 16. Aldo Leopold as Educator: His Legacy for Field Environmental Philosophy -- Chapter 17. Leopold’s Cultural Harvest, Biocultural Tourism and Field Environmental Philosophy -- Chapter 18. A Material Ecological Ethic for Biocultural Education: Relations Between Life on Earth and Humanity -- Chapter 19. Challenging the Dominant Grand Narrative in Global Education and Culture -- Part III: BIOCULTURAL RECONNECTION. RECOVERING THE SENSE OF COMMUNITY THROUGH EDUCATION -- Chapter 20. Introduction Part III. Biocultural Reconnection. Recovering the Sense of Community Through Education -- Chapter 21. Small, Silent and (In)Significant: Childhood as a Minoritarian Experience of Education -- Chapter 22. Communities of Philosophical Inquiry for the Empowerment of Ecological Agency -- Chapter 23. Biocultural Resilience Through Educational Tourism in Cholula, Mexico -- Chapter 24. Collaborative Action Research with the Jotï in Venezuela: Experiences in Autoethnography and TEK Vitality Assessment -- Chapter 25. Hand-Print CARE: Intergenerational and Plural Knowledge in Schools -- Chapter 26. The Enviro-Champs Movement: Co-Researching Transformation Through Training Processes in a Post COVID World -- Part IV: INTRODUCTION TO PLATFORMS FOR INTEGRATING THE SCIENCES, ARTS, AND HUMANITIES INTO PARTICIPATORY EDUCATION -- Chapter 27. Introduction Part IV. Introduction to Platforms for Integrating the Sciences, Arts, and Humanities into Participatory Education -- Chapter 28. Bridge the Channel, Enhance the Inclusivity: A Comparison Between Flagship Species-Centered and Moss-Centered Conservation in Chile and China -- Chapter 29. Biocultural Conservation in Biosphere Reserves in Temperate Regions of Chile, Estonia, Germany, and Sweden -- Chapter 30. Mindfulness and Reconnection with Freshwater Ecosystems at the Meadows Center Education Program -- Chapter 31. Nature, Humans, and Education: Ecohumanism as an Integrative Guiding Paradigm for Values Education and Teacher Training in Israel -- Chapter 32. The H.J. Andrews Experimental Forest Long-Term Ecological Research Program, Oregon, USA: A Historical Biocultural Perspective -- Chapter 33. Screens on Trails: Digital Environmental Science, Arts, And Humanities Learning for Biocultural Conservation -- Chapter 34. Reframing Sense of Place: A Goal for Environmental Education and an Indicator Supporting Social-Ecological Resilience.
    Abstract: This fifth volume in the Ecology and Ethics series integrates key concepts of the previous four volumes by addressing biocultural conservation through novel educational methods. In Field Environmental Philosophy (FEP), the authors undertake two complementary tasks. First, they address a problematic facet of education as an indirect driver of a global change and biocultural homogenization. Second, they contribute to solve the former problems by introducing the FEP method as well as other educational approaches from around the world that value and foster conservation of biological and cultural diversity. A particular emphasis is therefore on the integration of sciences, arts, humanities, and ethics into educational practices that involve the participation of local communities with their diverse forms of ecological knowledge and practices. The book is divided into four parts. Part I introduces FEP concepts and practices that involve a 4-step cycle of transdisciplinary research, poetic communication through composition of metaphors, design of field activities guided with an ecological and ethical orientation, and participation in biocultural conservation activities. Part II exposes problems as well as solutions in formal education (from preschool to higher education) and non-formal education to respect biocultural diversity. Parts III & IV provide case studies developed at long-term socio-ecological research (LTSER) sites, botanical gardens, and other platforms for non-formal education that contribute to biocultural conservation. This book supports a paradigm shift addressing still understudied indirect drivers of global change to foster the conservation of biological and cultural diversity. It is a valuable asset for scientists and practitioners in science and humanities education.
    Type of Medium: Online Resource
    Pages: XXI, 610 p. 123 illus., 102 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031233685
    Series Statement: Ecology and Ethics, 5
    URL: https://doi.org/10.1007/978-3-031-23368-5
    DOI: 10.1007/978-3-031-23368-5
    DDC: 333.9516
    Language: English
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    Precision Approaches to Heterogeneity in Asthma (2023)
    Cham :Springer International Publishing :
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    Keywords: Respiratory organs Diseases. ; Immunology. ; Immunogenetics. ; Human physiology. ; Pneumology. ; Immunology. ; Immunogenetics. ; Human Physiology.
    Description / Table of Contents: Introduction Part I -- The spectrum of asthma epidemiology -- Disease prevalence and burden -- Climate considerations in asthma and impacts of climate change -- Asthma across the ages: children, women, and the elderly -- Asthma as a systemic disease: neurologic, cardiac and metabolic changes in asthma -- Social determinants of health in asthma -- Part II. Mechanistic heterogeneity in asthma, -Phenotypes and endotypes -- Heterogeneity of treatment response to asthma (including mild-moderate asthma) -- Regional airway involvement: Imaging heterogeneity in ventilation, mucus and remodeling -- Biobehavioral determinants of asthma, including CNS influences and dietary/nutrition -- Integrative/ Systems levels studies -- Part III. Severe and difficult to treat asthma endotypes -- Definition, phenotyping of severe asthma, including cluster analysis -- Asthma exacerbations: patient features and potential long-term implications -- Innate inflammation driven remodeling -- Adaptive immunity and remodeling -- Part IV. Influence of heterogeneity on approaches to management -- Approaches to management of asthma -- Guidelines for stepped care and self-monitoring -- Global considerations in asthma treatment - management in low resource settings -- Update on biomarker-driven approaches and precision medicine- adaptive clinical trials e.g., PRECISE -- Conclusion and future directions.
    Abstract: Asthma has been challenging to treat due to its heterogeneous onset, environmental triggers, severity, and treatment response. To embrace the rapid advances in this field, Precision Approaches to Heterogeneity in Asthma follows its highly successful predecessor, Heterogeneity in Asthma. In this new volume, noted authorities Allan Brasier and Nizar Jarjour and a cadre of leaders in the field incorporate new work advancing our understanding of phenotypes (endotypes) of disease, regional variations in ventilation, systems approach to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials. This work will facilitate our current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions. .
    Type of Medium: Online Resource
    Pages: X, 418 p. 71 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031322594
    Series Statement: Advances in Experimental Medicine and Biology, 1426
    URL: https://doi.org/10.1007/978-3-031-32259-4
    DOI: 10.1007/978-3-031-32259-4
    DDC: 616.2
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    Neglected Plant Foods Of South Asia : Exploring and valorizing nature to feed hunger (2023)
    Cham :Springer International Publishing :
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    Keywords: Food science. ; Food security. ; Food Safety measures. ; Food Microbiology. ; Food Science. ; Food Security. ; Food Safety. ; Food Microbiology.
    Description / Table of Contents: Chapter 1: Agricultural biodiversity and food security: Opportunities and challenges -- Chapter 2: Role of neglected plant foods in achieving dietary diversity, zero hunger and good health -- Chapter 3: Exploring neglected and underutilized plant foods to fight malnutrition and hunger in South Asia -- Chapter 4: Inclusion criteria of underutilized food plants in household food security planning -- Chapter 5: Neglected plant foods of India -- Chapter 6: Neglected plant foods of Pakistan -- Chapter 7:Neglected plant foods of Bangladesh -- Chapter 8: Exploring social-ecological systems for mainstreaming neglected and underutilised plant foods: local solutions to food security challenges in Sri Lanka -- Chapter 9: Neglected plant foods of Nepal -- Chapter 10: Grain millet: Potential to fill nutrition gaps in the context of food security and climate change -- Chapter 11: Amaranth (Amaranthus spp.): Food properties and potential health benefits -- Chapter 12: Moringa (Moringa oleifera): Multi-functional role in management of malnutrition and health promotion -- Chapter 13: Date palm (Phoenix dactylifera): A review of economic potential, industrial valorization, nutritional and health significance -- Chapter 14: Quinoa (Chenopodium quinoa): Potential of the “golden grain” for food and nutritional security in South Asia -- Chapter 15: Sweet potato (Ipomoea batatats): An intervention food in management of food and nutritional security in South Asia -- Chapter 16: Taro (Colocasia spp.): Applications in food production and improving nutrition in South Asia -- Chapter 17: Jackfruit (Artocarpus heterophyllus): An overview of nutritional and functional food properties -- Chapter 18: Fenugreek (Trigonella foenum-graecum): An overview of food uses and health benefits.
    Abstract: According to the global hunger index, South Asia has worldwide highest rate of undernourished people. Such a burden of food insecurity and various forms of malnutrition are directly associated with the existing food production system that ignores biodiversity, food affordability, and sustainability. During the last five decades, food production system has witnessed a global shift from ethnic to mainstream staple cereals production and promotion. Such an approach has badly affected the regional genetic pool of a diverse range of nourishing, economical, and sustainable edible plant species which are now referred to as neglected or underutilized food crops. Neglected Plant Foods of South Asia collects and preserves existing knowledge of underutilized, minor, wild, neglected and traditional food plants of South Asia, and their utilization for the production of value-added food products. Aiming at introducing plant – based food solutions to address the increasing burden of food insecurity among marginalized communities of South Asia, this manuscript covers a plethora of nutrient-dense plant species including fruits, vegetables, roots, tubers, cereals, pseudo-cereals, and pulses. In addition to having an overview of each plant's origin, cultivation practices and production statistics, researchers will find comprehensive information on nutritional composition, food manufacturing properties, value-addition and traditional uses of neglected plant foods. Recent updates on strategies to combat toxicological risks associated with the consumption of neglected food plants have also been included. With this volume, researchers will have complete information on neglected, underutilized traditional edible plants of South Asia, and their potential to increase food security under the emerging challenges of climate change.
    Type of Medium: Online Resource
    Pages: XX, 476 p. 63 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031370779
    URL: https://doi.org/10.1007/978-3-031-37077-9
    DOI: 10.1007/978-3-031-37077-9
    DDC: 641.3
    Language: English
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    Infectious Diseases along the Silk Roads : The Spread of Parasitoses and Culture Past and Today (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Parasitology. ; Diseases. ; Paleoecology. ; Civilization History. ; Public health. ; Parasitology. ; Diseases. ; Paleoecology. ; Cultural History. ; Public Health.
    Description / Table of Contents: Part 1: The Silk Roads: Past and Future -- Chapter 1: Network expansion and disease spread along the former and present straits of the Silk Road(s) and other international straits -- Chapter 2: Belt and Road Initiative Revisited -- Chapter 3: Economic Development and Health Care Status in Silk Road Countries -- Chapter 4: Traditional medicines along the BRI countries -- Part 2: Parasite and Disease Spread along the Silk Roads: A Review to date -- Chapter 5: Infectious diseases in Belt and Road Initiative (BRI) countries -- Chapter 6: Disease details on plague (Black Death), cholera, brucellosis, and tick-borne encephalitis along the Silk Road(s) of former and recent times -- Chapter 7: Plague disease – from Asia to Europe and back along the Silk Road -- Chapter 8: Dengue along the silk road -- Chapter 9: Intestinal Parasites at the Xuanquanzhi relay station on the Silk Road 2,000 Years Ago -- Chapter 10: Dicrocoelium in Iran: From Bronze Age to the 21st century -- Chapter 11: Development of vaccines to stop endemic of hydatid diseases and promote connectivity of BRI.
    Abstract: The heart of this volume is exploring the links between human disease spread and the broad Silk Road trading networks which connect Eurasian civilizations past and today. Compiled by an international team of subject authors, this book includes two themed parts. Readers are first introduced into history naming, former, present and future routes of the Silk Road, representing the longest trade way and culture diffuser in the world. The second part contains the main book focus and addresses medical research as well as individual diseases and parasite groups from the region in detail. By drawing an arc between the past and present disease situation, the authors trace how parasites and vectors spread around the globe, and what impact infectious diseases had and will have upon human civilizations. Through its interdisciplinary character this book will be enjoyed by interested readers from the fields of parasitology and palaeoparasitology, medical sciences and public health, as well as cultural history.
    Type of Medium: Online Resource
    Pages: VI, 174 p. 25 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031352751
    Series Statement: Parasitology Research Monographs, 17
    URL: https://doi.org/10.1007/978-3-031-35275-1
    DOI: 10.1007/978-3-031-35275-1
    DDC: 571.999
    Language: English
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    Biomaterials and Biopolymers (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmaceutical chemistry. ; Biomaterials. ; Pharmacology. ; Drug delivery systems. ; Vaccines Biotechnology. ; Pharmaceutics. ; Biomaterials. ; Pharmacology. ; Drug Delivery. ; Biomaterials-Vaccines.
    Description / Table of Contents: Introduction to Biomaterials -- Biodegradable Polymers -- Natural and semi-natural polymers -- Fundamentals and Biomedical Applications of Smart Hydrogels -- Engineering biomaterials for nucleic acid-based therapies -- Mechanics of Biomaterials for Regenerative Medicine -- Biomaterials for controlled drug delivery applications -- BIOMATERIALS APPLICATION: IMPLANTS -- Living Biomaterials -- Therapeutic Polymer Conjugates and their Characterization -- Biocompatibility of Polymers -- Sterilization techniques of biomaterials (implants and medical devices).
    Abstract: This book intends to serve as textbook for faculty and students and thus contains a broad introduction and basic terms of biomterials and biopolymers followed by major developments over the years with some emphasis on recent developments and future prospects. The book provides a comprehensive overview in biomaterials and biopolymers. All relevant aspects of modern biomaterials, including: synthesis and characterization, biocompatibility and host respond, the implementation of novel manufacturing processes, and advanced medical and biotechnological applications. Each chapter provides an overview of a specific field, its importance, the chemistry of biomaterials and the relations between chemical structure and the applications. Each chapter ends with a future prospective/concepts and a friendly quiz/multiple answer questions with answers that serves as a resource to provide guided additional practice.
    Type of Medium: Online Resource
    Pages: XII, 272 p. 76 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031361357
    Series Statement: AAPS Introductions in the Pharmaceutical Sciences, 7
    URL: https://doi.org/10.1007/978-3-031-36135-7
    DOI: 10.1007/978-3-031-36135-7
    DDC: 615.19
    Language: English
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    Glycobiology of the Nervous System (2023)
    Cham :Springer International Publishing :
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    Keywords: Neurosciences. ; Zoology. ; Neurochemistry. ; Neuroscience. ; Zoology. ; Neurochemistry.
    Description / Table of Contents: 1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates. -- 2. Introduction to cells comprising the nervous system. -- 3. Synthesis -- processing -- and function of N-glycans in N-glycoproteins. -- 4. Synthesis of O-linked glycoconjugates in the nervous system. -- 5. Chemistry and function of glycosaminoglycans in the nervous system. -- 6. Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system. -- 7. Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics. -- 8. Structural analysis of oligosaccharides and glycoconjugates using NMR. -- 9. Glycolipid and glycoprotein expression during neural development. -- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide). -- 11. Role of myelin-associated glycoproteins in the peripheral nervous system. -- 12. Glycosignaling: a general review. -- 13. Glycosphingolipids in the regulation of the nervous system. -- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration. -- 15. Glycoconjugates in nuclear membranes. -- 16. N-glycosylation in regulation of the nervous system. -- 17. Role of carbohydrates in the interaction of pathogens with neural cells. -- 18. Glycoconjugate changes in aging and age-related diseases. -- 19. Gangliosides and glycolipids in neurodegenerative disorders. -- 20. Inborn errors of glycosphingolipid catabolism and potential treatment. -- 21. Neurological aspects of human glycosylation disorders. -- 22. Glycoconjugates and neural tumors. -- 23. Galectins and neuroinflammation . -- 24. Glycoconjugates and neuroimmunological diseases. -- 25. Targeting nanoparticle drug carriers to the brain. -- 26. Use of quantum dots to treat inherited lysosomal storage diseases. -- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates.
    Abstract: This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.
    Type of Medium: Online Resource
    Pages: XII, 501 p. 96 illus., 73 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031123900
    Series Statement: Advances in Neurobiology, 29
    URL: https://doi.org/10.1007/978-3-031-12390-0
    DOI: 10.1007/978-3-031-12390-0
    DDC: 612.8
    Language: English
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    Mastering Your Dissertation : The Answers to Your Questions on Bachelor´s, Master´s and Project Theses (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biology. ; Medical sciences. ; Dissertations, Academic. ; Penmanship. ; Research Methodology. ; Biological Sciences. ; Health Sciences. ; Thesis and Dissertation. ; Writing Skills. ; Research Skills.
    Description / Table of Contents: Chapter 1: What will this book cover? -- Chapter 2: How can I get organised? -- Chapter 3: How do I choose a project type and title? -- Chapter 4: What is the best way to work with my supervisor? -- Chapter 5: Do I need to complete an ethics form? -- Chapter 6: How do I write an Introduction? -- Chapter 7: How do I write the Methods chapter? -- Chapter 8: How should I present my Results? -- Chapter 9: How do I write the Discussion chapter? -- Chapter 10: How do I write the Conclusion? -- Chapter 11: How do I reference? -- Chapter 12: Does my dissertation need an abstract? -- Chapter 13: What else should I include in my dissertation? -- Chapter 14: How do I prepare and conduct a successful defense? -- Chapter 15: Other frequently asked questions.
    Abstract: This reader-friendly guide is specifically designed for any student who has ever had a question about theses as part of their university undergraduate degree course in a life- or health science-related subject. It covers the varied types of projects that exist, including experimental work, surveys, meta-analyses, audits and qualitative and quantitative studies - all in one place. Get support at planning, completing and writing of your research based thesis. By using examples and check lists, this book leads you through the entire process encompassing each chapter of the dissertation. Let the question and answer writing style encourage you and boost your confidence when embarking on what is probably your largest piece of work to date, solved in a step by step approach. The experienced authors have run an enormous number of web and face-to-face workshops to support students in life and health sciences and help them write their dissertations. It became clear that research theses are a considerable source of anxiety and that many essential questions need answering - this book is your solution.
    Type of Medium: Online Resource
    Pages: XVII, 165 p. 15 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031419119
    URL: https://doi.org/10.1007/978-3-031-41911-9
    DOI: 10.1007/978-3-031-41911-9
    DDC: 570
    Language: English
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    Oxygen Transport to Tissue XLIV (2023)
    Cham :Springer International Publishing :
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    Keywords: Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .
    Abstract: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 49th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2022). Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
    Type of Medium: Online Resource
    Pages: XIX, 240 p. 91 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031420030
    Series Statement: Advances in Experimental Medicine and Biology, 1438
    URL: https://doi.org/10.1007/978-3-031-42003-0
    DOI: 10.1007/978-3-031-42003-0
    DDC: 571.6
    Language: English
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    Mechanisms and Emerging Therapies in Tremor Disorders (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Neurosciences. ; Nervous system Diseases. ; Biomedical Research. ; Neurology. ; Neuroscience. ; Neurological Disorders.
    Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.
    Abstract: Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
    Type of Medium: Online Resource
    Pages: X, 558 p. 86 illus., 59 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031261282
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-26128-2
    DOI: 10.1007/978-3-031-26128-2
    DDC: 610.72
    Language: English
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    Olfactory Research in Dogs (2023)
    Cham :Springer International Publishing :
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    Keywords: Veterinary medicine. ; Physiology. ; Cognition in animals. ; Veterinary Science. ; Animal Physiology. ; Animal Cognition.
    Description / Table of Contents: Part I. Fundamentals of Olfaction -- Chapter 1. Peripheral olfactory pathway anatomy, physiology and genetics (Melissa Singletary) -- Chapter 2. Neuroanatomy and neurophysiology of the olfactory signal transduction pathway (Melissa Singletary) -- Chapter 3. Canine olfactory dysfunction (David Dorman) -- Part II. Methodological Considerations -- Chapter 4. Behavioral Characteristics Associated with Detection Dog Success (Lucia Lazarowski) -- Chapter 5. Canine Olfactometry: Tools, Techniques and Procedures (Lauryn DeGreeff) -- Chapter 6. Sources of Human Bias in Canine Olfactory Research (Sarah Krichbaum) -- Chapter 7. Human scent dynamics – combining theory and practice in locating people (G.A.A. Schoon) -- Part III. The role of olfaction in dog cognition and welfare, and for learning and training methods.
    Abstract: This book unites cutting-edge research related to various aspects of dog olfaction. It includes rich expertise about detection dogs with application perspectives, and expands beyond. In four clearly arranged sections, readers will discover specialist contributions on: the fundamentals of olfaction, anatomy, comparative olfactory neuroscience and dysfunction methodological reflections on canine olfactometry and essential implications for practice, comprising dog selection for scent detection, handler bias and signal detection concepts the connection with dog behavior, cognition, welfare, and learning and training methods diverse application examples of dog olfactory capabilities, such as disease detection for diagnostics, infectious disease surveillance, forensics and ecological conservation The unique and exciting link between science and practice makes this book a valuable read not only for researchers, but also for practicing veterinarians and professionals in the fields of canine detection, chemical sensing, working dog behavior and welfare.
    Type of Medium: Online Resource
    Pages: VI, 440 p. 28 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031393709
    URL: https://doi.org/10.1007/978-3-031-39370-9
    DOI: 10.1007/978-3-031-39370-9
    DDC: 636.089
    Language: English
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    Metabolomics : Recent Advances and Future Applications (2023)
    Cham :Springer International Publishing :
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    Keywords: Metabolism. ; Biochemical markers. ; Plant diseases. ; Cancer. ; Neurosciences. ; Drug delivery systems. ; Metabolism. ; Biomarkers. ; Plant Pathology. ; Cancer Metabolism. ; Neuroscience. ; Drug Delivery.
    Description / Table of Contents: Introduction of metabolomics -- Metabolomics Data Analysis and Tools -- Role of metabolomics in the development of new avenues in fundamental biology research -- Metabolomics in epidemiology -- Pharmacometabolomics: General use of metabolomics in pharmacy and drug development -- Metabolomics in microbiological research and applications -- Application and developments of metabolomics in physiological diseases -- Nutrimetabolomics: metabolomics in nutrition research -- Metabolomics in natural product discovery and their application -- Metabolomics approach in environmental studies -- Emerging metabolomics methodologies, and research in agriculture -- Metabolomics in fundamental plant research -- Integration of metabolomics with other omics: tools and general applications -- Future perspectives of metabolomics: gaps, recommendations, and planning.
    Abstract: This book Introduces the extensive applications of metabolomics from all possible areas of research and development so that not only an undergraduate can understand the advancement of metabolomics, but an entrepreneur can harness the knowledge to address possible problems to make a perfect tool to address their research question. Topics covered include the role of metabolomics in the development of agriculture, plant pathology, and their applications; the generalized application of the metabolomics and use of related technologies in various sectors of industries; and the future of metabolomics and upcoming related technologies that can fill the gap between different -omics and their applications for the betterment of humankind. This is an ideal book for university professors, researchers, and advanced-level scientists who are exploring different avenues in metabolomics. Availability of this concise information in one place will aid scientists by expanding their arsenal of techniques and can be helpful to bring more collaborations and to identify the expert at the global level.
    Type of Medium: Online Resource
    Pages: XIV, 517 p. 94 illus., 85 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390944
    URL: https://doi.org/10.1007/978-3-031-39094-4
    DOI: 10.1007/978-3-031-39094-4
    DDC: 572.4
    Language: English
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    Recent Advances in Citrus Fruits (2023)
    Cham :Springer International Publishing :
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    Keywords: Food science. ; Food Microbiology. ; Food Science. ; Food Engineering. ; Food Microbiology.
    Description / Table of Contents: Lemons and limes -- Grapefruit -- Mosambi -- Orange -- Pomelo -- Tangerine (Citrus reticulata) -- Etrog citron (Citrus medica var. ethrog Engl) -- Jabara (Citrus jabara) -- Kumquat -- Greek citron (Citrus medica) -- Kinnow -- Post Harvest Handling Of Citrus Fruits -- Citrus based food products and their shelf life -- Citrus waste: A treasure of promised phytochemicals and its nutritional-nutraceutical value in health promotion and Industrial applications -- Bioactive compounds in citrus fruits: Extraction and identification -- Potential benefits of bioactive functional components of Citrus fruits for health promotion and disease prevention -- Citrus Diseases And Management.
    Abstract: When compared to other major fruits, citrus fruits have resistance to pests and diseases, a short growing season and productivity even under harsh environmental conditions. Worldwide, citrus fruits are well known for their nutrients-rich juice and medicinal properties. Juice extracted from citrus fruits is rich source of vitamin C and various antioxidant compounds that are required to sustain a healthy life. Fruits are consumed in raw as well as processed forms, and the pharmacological importance of citrus fruits are not only limited to its edible parts, but also to non edible seeds and peel that are also a rich source of bioactive constituents with health benefiting properties. In current fruit processing techniques the peel is discarded as a byproduct after extraction of the juice. Researchers and food scientists are now focusing on utilization of fruit waste/byproducts to use them as a substrate in food processing, cosmetic and pharmaceutical industries. Whole fruits, seeds contain important antioxidant and antimicrobial properties. Recent Advances in Citrus Fruits provide in-depth knowledge on the nutritional profile, production details, processing, products and health benefits of citrus fruits. The most important citrus fruits, from lemons and limes to grapefruit and mosambi are covered in full, providing researchers with full breakdowns on each citrus fruit's nutritional makeup, processing specifics and agrarian importance, health benefits and use in various products across a wide range of industries. This text covers all of the latest research related to citrus fruits and provides researchers with a curated source on these valuable fruits.
    Type of Medium: Online Resource
    Pages: XIX, 529 p. 51 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031375347
    URL: https://doi.org/10.1007/978-3-031-37534-7
    DOI: 10.1007/978-3-031-37534-7
    DDC: 641.3
    Language: English
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    Scabies (2023)
    Cham :Springer International Publishing :
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    Keywords: Parasitology. ; Internal medicine. ; Medical microbiology. ; Parasitology. ; Internal Medicine. ; Medical Microbiology.
    Description / Table of Contents: Preface -- History of scabies -- Parasitology and Basic research -- Biology of scabies (systematics, morphology, life cycle) -- Genotyping and Host Specificity -- Host immune response to scabies -- Scabies Mite Biochemical Research – an overview -- Scabies multi-omics as a way to bring the basic science up to speed -- Scabies associated microbiota -- Experimental animal models -- Epidemiology and burden of scabies – Public health issues -- Epidemiology and risk factors -- Public health issues, Scabies surveillance and awareness -- Scabies and secondary infections -- Scabies, the 17th NTD in the WHO list - Role of IACS -- Clinical manifestations and management -- Clinic – classic scabies and special forms (except pediatric) -- Clinic – pediatric -- Diagnosis of Scabies -- Parasitological diagnosis -- Non-invasive diagnosis -- Potential for sensitive and simple molecular diagnostic tools -blood tests for scabies -- Animal scabies -- Treatment management (adults and children) and drug resistance -- Scabies mass treatment in poor-resource countries -- Management in health care facilities -- New treatment solutions.
    Abstract: This edited volume covers all aspects of the Neglected Tropical Disease Scabies. The contributions are organised into four themed parts. The first part reviews the history of the disease and its treatment and management, part two is dedicated to parasitology and basic research on the disease causing parasite, Sarcoptes scabei. Epidemiology and disease burden including public health issues are discussed in the third part in detail. The last section of the book is covering clinical manifestation and management. This volume is the first one of its kind, providing an insight into all aspects of the skin disease which is causing considerable morbidity and mortality. Chapters are all written by dedicated experts in their respective area of interest making the publication a must have for all scientists and clinicians as well as public health specialists dedicated to Scabies research in any aspect.
    Type of Medium: Online Resource
    Pages: IX, 482 p. 80 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031260704
    URL: https://doi.org/10.1007/978-3-031-26070-4
    DOI: 10.1007/978-3-031-26070-4
    DDC: 571.999
    Language: English
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    Cardiovascular Neuroendocrinology (2023)
    Cham :Springer International Publishing :
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    Keywords: Neurophysiology. ; Neurons. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Endocrinology. ; Cellular Neuroscience. ; Cardiovascular Physiology. ; Cardiology. ; Endocrinology.
    Description / Table of Contents: Part I. Neuroendocrine Systems and Cardiovascular Function -- Chapter 1. Neural Control of Cardiovascular Function: Role of Osmosensation -- Chapter 2. Central Neuroendocrine Control of the Cardiovascular System -- Chapter 3. Neuroendocrine Control of the Vascular System -- Chapter 4. Sex Differences in Vascular Function -- Part II. Neuroendocrinology of Cardiovascular Dysfunction and Aging -- Chapter 5. Cardiovascular Neuroendocrinology of Pregnancy -- Chapter 6. Cerebrovascular Function in Aging -- Chapter 7. Cardiovascular Responses to Exercise in Diabetes -- Chapter 8. Interactions of Stress, Psychology, and Cardiovascular Function -- Chapter 9. Neuroendocrinology Therapeutic Pathways for Cardiovascular Disease.
    Abstract: The cardiovascular system and the neuroendocrine system are integrated at multiple levels. This integration is key to normal physiological function. Further, it adapts to accommodate changes related to aging, the organism’s reproductive state, or physiological challenges. This type of adaptability, or plasticity, also can contribute to pathophysiology when these systems are stressed. This volume discusses how neuroendocrine systems influence cardiovascular function in health and disease. The first section provides detailed background information on neuronal and neuroendocrine control of cardiovascular function. This is followed by chapters highlighting the cardiovascular role of neuroendocrine hormones in regulating physiological states, such as pregnancy, and the effects of biological sex on vascular function. The influence of exercise, stress, psychology, and aging on cardiovascular function and dysfunction, and the possibility of therapeutically targeting the neuroendocrine axis for the treatment of cardiovascular disease are discussed in the final section of the book. This book is of relevance for students, trainees and established researchers alike who are seeking for an overview on the neuroendocrine control of cardiovascular function and disease. This is the fourteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
    Type of Medium: Online Resource
    Pages: IX, 238 p. 27 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031399954
    Series Statement: Masterclass in Neuroendocrinology, 14
    URL: https://doi.org/10.1007/978-3-031-39995-4
    DOI: 10.1007/978-3-031-39995-4
    DDC: 612.81046
    Language: English
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    Dendritic Spines : Structure, Function, and Plasticity (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurophysiology. ; Developmental neurobiology. ; Neuroscience. ; Neurophysiology. ; Development of the Nervous System.
    Description / Table of Contents: Chapter 1: Introduction: What are dendritic spines? -- Chapter 2: Techniques to render dendritic spines visible in the microscope -- Chapter 3: Electrophysiology of dendritic spines: information processing, dynamic compartmentalization and synaptic plasticity -- Chapter 4: Dendritic spines, synaptogenesis and synaptic pruning for the developmental organization of brain circuits -- Chapter 5: Neurotrophic factors and dendritic spines -- Chapter 6: Glial cell modulation of dendritic spine structure and synaptic function -- Chapter 7: Dendritic spines in learning and memory: from first discoveries to current insights -- Chapter 8: Steroid hormone interaction with dendritic spines: implications for neuropsychiatric disease -- Chapter 9: Morphological features of human dendritic spines.
    Abstract: This reference provides detailed coverage of dendritic spines, the fascinating neuronal components that modulate synaptic transmission, development, strength, and plasticity and are involved in the function of multiple areas of the nervous system. The density, shape, and function of spines may indicate the cellular connectivity and synaptic plasticity in normal and pathological conditions. This field has undergone dramatic advances in terms of techniques and experimental findings from in vitro to in vivo data, from animal models to human neurons, and computational models using artificial intelligence. To address these cutting-edge findings, the book provides state-of-the-art, comprehensive coverage with chapters written by the leading international researchers in the field. The authors consider the multiple implications for the study of dendritic spines with broad implications in the neurosciences and related areas.
    Type of Medium: Online Resource
    Pages: XV, 499 p. 123 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031361593
    Series Statement: Advances in Neurobiology, 34
    URL: https://doi.org/10.1007/978-3-031-36159-3
    DOI: 10.1007/978-3-031-36159-3
    DDC: 612.8
    Language: English
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    Human Parasites : Diagnosis, Treatment, Prevention (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Parasitology. ; Medical microbiology. ; Zoology. ; Public health. ; Veterinary microbiology. ; Tropical medicine. ; Parasitology. ; Medical Microbiology. ; Zoology. ; Public Health. ; Veterinary Microbiology. ; Tropical Medicine.
    Description / Table of Contents: Chapter 1: The Phenomenon Parasitism -- Chapter 2: Which Parasites Are Important for Humans? -- Chapter 3: Protozoans Attacking Humans -- Chapter 4: Worms of Humans -- Chapter 5: Arthropods.
    Abstract: The new edition of this textbook provides an up-to-date overview of the most important parasites in humans and their potential vectors. Climate change and globalization steadily favor the opportunities for parasites to thrive. These challenges call for the latest information on pathogen transmission routes and timely preventive measures. For each parasite, this book offers a concise summary in eleven sections: 1. Naming 2. Geographic distribution and epidemiology 3. Morphology, biology and life cycle 4. Disease symptoms 5. Diagnosis 6. Infection pathways 7. Prophylaxis 8. Incubation period 9. Prepatency 10. Patency 11. Therapeutic options Numerous tables, diagrams and over 200 colorful illustrations highlight the main aspects of parasitic infestations and present suitable control measures. Moreover, 60 questions help to test readers’ theoretical knowledge of the field. Readers can additionally download the free Springer Nature Flashcards App and benefit from the digital study questions. In short, this work is highly recommended for anyone looking to delve into the field of human parasitology. It is intended for students of biology and human medicine, medical doctors, pharmacists and laboratory staff alike. Furthermore, persons who plan to visit or live longer in endemic regions will find essential information on necessary preventive and control measurements.
    Type of Medium: Online Resource
    Pages: XVII, 430 p. 223 illus., 217 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031417054
    URL: https://doi.org/10.1007/978-3-031-41705-4
    DOI: 10.1007/978-3-031-41705-4
    DDC: 571.999
    Language: English
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    Fear Extinction : From Basic Neuroscience to Clinical Implications (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuropsychology. ; Clinical psychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Clinical Psychology. ; Psychiatry.
    Description / Table of Contents: Preface -- PART 1: To fear or not -- Disambiguating fear as an emotional state vs. threat detection. Molecular and Neural circuits of fear extinction. Psychological and theoretical elements on the concept of fear extinction. Neural circuit of fear extinction: psychophysiology -- PART 2: Individual differences in fear extinction -- The impact of sex differences and sex hormones on fear extinction. Impact of sleep on fear extinction. Impact of stress and exercise on fear extinction. Intersect between the intrinsic and extrinsic factors that modulate fear extinction -- PART 3: Psychopathology -- Fear extinction and its relevance to psychopathology. Developmental fear and its extinction imaging. Fear extinction and adult psychopathology -- Part 4: Therapeutics and neuromodulations of fear extinction -- Exposure therapy and other behavioral therapeutics targeting fear extinction circuits. Novel pharmacotherapeutics targeting fear extinction circuits. Reconsolidation and its link and impact on fear extinction. Technological advances in exposure therapy: virtual and augmented reality. Novel approaches using neurostimulation targeting fear extinction.
    Abstract: This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears. The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.
    Type of Medium: Online Resource
    Pages: VIII, 387 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031430053
    Series Statement: Current Topics in Behavioral Neurosciences, 64
    URL: https://doi.org/10.1007/978-3-031-43005-3
    DOI: 10.1007/978-3-031-43005-3
    DDC: 612.8
    Language: English
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    Biology of Women’s Heart Health (2023)
    Cham :Springer International Publishing :
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    Keywords: Cardiovascular system. ; Physiology. ; Cardiology. ; Medicine Research. ; Biology Research. ; Medical sciences. ; Health. ; Sex. ; Cardiovascular Physiology. ; Cardiology. ; Biomedical Research. ; Health Sciences. ; Gender and Health.
    Description / Table of Contents: Attenuation of Bnip3 Mediated Doxorubicin-Induced Cell Death in Cardiac Myocytes -- Sex Dependent Regulation of Circadian Rhythms in Health and Disease -- Circadian Pharmacological Approach to Treat Myocardial Infarct -- GPER Function as a Determinant of the Progression of Atherosclerotic Disease in Women -- Novel Therapeutic Approach to Treat Cardiac-Rheumatology in Females -- Correlation between Sex, Immigration Status, Ethnicity, and Long-term Outcomes of Ischemic Stroke -- Risk Assessment and Predictive Modelling for The Heart-Brain Interface in Women -- Insomnia Interventions for Female Cardiac Patients -- Aortic Stenosis Progression, Cardiac Damage, and Survival: Comparison Between Men and Women -- Treatment and Management of Valvular Heart Disease and Cost-Effectiveness Analysis -- Association of Mortality and Acute Aortic Events with Ascending Aortic Aneurysm -- Improving Diagnosis and Treatment for Patients Who Suffer Spontaneous Coronary Artery Dissection (SCAD) -- Preeclampsia and Future Cardiovascular Health -- Cardiovascular Disease in Women with a History of Pregnancy Complications -- Hormone Replacement Treatment for Cardiovascular Disease -- Cardiovascular Mortality Following Early-Stage Breast Cancer -- Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease in Women -- Sex Differences in Cardiac Rehabilitation Enrollment -- Promoting Exercise and Physical Activity in Female Patients with Heart Disease -- Sex and Gender Differences in the Diagnosis, Treatment, and Outcomes of Coronary Artery Disease -- Sex Differences in Arterial Aging and its Implications on Cardiovascular Diseases -- Impact of a Novel Community-Based Lifestyle Intervention Program on Type 2 Diabetes and Cardiovascular Risk -- Clinical Outcomes Related to Heart Failure and Pulmonary Hypertension -- Examination of Health-Related Quality of Life in Women with Coronary Artery Disease -- The Risks and Benefits of Implantable Cardioverter-Defibrillator Generator Replacement -- The Effects and Roles of Estrogen in Managing Hypertension in Menopausal Women -- The Effects of Menopausal Hormone Therapy on the Vascular System -- Influence of Sex Differences in Non-Obstructive Coronary Artery Disease -- Diet1 and Resistance to High Cholesterol Levels and Cardiovascular Disease -- Interventions to Improve Clinical Outcomes Following Hospitalization for Heart Failure -- Sex-Dependent Cardioprotective Effects of the Phytoestrogen Resveratrol -- Blood Pressure Across a Woman's Life Cycle -- Women’s Fitness Levels and Heart Rate Response to Exercise -- Supervised Exercise Therapy Through Cardiac Rehabilitation following Peripheral Arterial Disease -- Sex Differences in ANT2-Mediated ATP Import into Mitochondria for Protection Against Hypoxia Lethal Injury.
    Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women and men worldwide and represents a major financial burden to world health care systems. Importantly, CVD has eclipsed cancer as the leading cause of death for women globally. Through advancements in research and clinical testing, the symptoms and risk factors for CVD have been well established for men, but not for women. Consequently, there is an immediate need for new innovative research that will bridge this gap and allow for improved early diagnosis and treatment of CVD in women. This book will serve as a guide for health care providers to better understand the physiological, biochemical, and genetic differences in heart disease in women with the goal of providing improved education, awareness and treatment of cardiovascular disease in women. The book will cover topics such as: sex dependent clinical outcomes of cardiovascular disease, cardiac protection by estrogen, cardiac health during menopause, cardiac rehabilitation programs, fitness and exercise, cardio-oncology, shift work and the CVD risk, and pregnancy related CVD.
    Type of Medium: Online Resource
    Pages: VII, 446 p. 56 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031399282
    Series Statement: Advances in Biochemistry in Health and Disease, 26
    URL: https://doi.org/10.1007/978-3-031-39928-2
    DOI: 10.1007/978-3-031-39928-2
    DDC: 573.1
    Language: English
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    RNA Structure and Function (2023)
    Cham :Springer International Publishing :
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    Keywords: Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Biochemistry. ; Medical genetics. ; Cytology. ; Genetics. ; Structural Biology. ; Biochemistry. ; Medical Genetics. ; Cell Biology. ; Genetics and Genomics.
    Description / Table of Contents: 1. Computational Tools for Functional Analysis of Circular RNAs -- 2. The Hidden Layer of RNA Variants -- 3. Functional Role of Non-Coding RNAs in Prostate Cancer: From Biomarker to Therapeutic Targets -- 4. The structure, function, and modification of non-coding RNAs in cardiovascular system,- 5. Contribution of RNA Species in Sexually Transmitted Infections -- 6. Hypoxia and Epithelial-to-Mesenchymal Transition (EMT) in Cancer: A Non-Coding RNA Perspective -- 6. A Study on the Role of piRNAs in Cancer Epigenetics -- 7. Modified Nucleosides as RNA Components. Structure, Biological Role and Drug Design -- 8. Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death -- 9. Incorporation of Pseudouridine into RNA for Biochemical and Biophysical Studies -- 10. Molecular Dynamics Simulations of Chemically Modified Ribonucleotides.
    Abstract: This book focuses on the current status of our understanding of RNA, a key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA, noncoding RNAs, modified nucleosides, and RNA enzymes. The different chapters detail methods to investigate RNA structure and function, the chemistry of modified RNAs, and the latest advances in our understanding of the vast array of biological processes in which RNA is involved. RNA, in one form or another, touches almost everything in a cell. RNA has both structural and catalytic properties. RNA fulfills a broad range of functions. These molecules are no longer seen as passive elements transferring the genetic information from DNA into proteins but regulate the activity of genes during development, cellular differentiation, and changing environments. RNAs are involved in various aspects of cell physiology and disease development. Discoveries of RNA with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as both the source and countermeasure to cancer or severe viral infection, stimulate new trends, passion, and solutions for molecular medicine. In this book, fundamental questions about the biochemical and genetic importance of RNA, how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, how to determine RNA structure and how to apply RNA in treatment of diseases. This book is an essential resource for researches in academia and industry contributing to the development of new RNA therapeutics. The book is geared toward scientists from the graduate level on up and particularly appeals to active investigators in RNA biology, molecular biology, and biochemistry.
    Type of Medium: Online Resource
    Pages: XI, 666 p. 134 illus., 123 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031363900
    Series Statement: RNA Technologies, 14
    URL: https://doi.org/10.1007/978-3-031-36390-0
    DOI: 10.1007/978-3-031-36390-0
    DDC: 572.8
    Language: English
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    Cereal-Based Food Products (2023)
    Cham :Springer International Publishing :
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    Keywords: Food science. ; Food Analysis. ; Chemistry. ; Food Science. ; Food Engineering. ; Food Chemistry.
    Description / Table of Contents: Introduction to cereals -- Bread; Cookies and Biscuit -- Cakes and muffins -- Tortillas -- Crackers -- Popped and puffed products -- Flaked products -- Pasta -- Noodles -- Beverages -- Pastry -- Packaging of cereal products.
    Abstract: Cereal grains and their products are staples in the diet of almost every culture of the world and have made an important contribution to daily nutrient requirements. Cereal grains are high in carbohydrates, good sources of protein and provide varying amounts of fibre, vitamins and minerals. The nutritional composition of grains may vary depending on the variety and environmental growing conditions. A number of cereal products are prepared from all the regions of the world. Cereals are processed into many products such as bread, cookies, cakes and pasta and are consumed daily by the majority of the population and play an important place in human nutrition. Cereal Based Food Products is the first book of its kind, focusing on the preparation methodology of cereal products. The chapters focus on different types of cereal products, processing technology, quality aspects and packaging requirements. All of the important cereal-based foods are covered in full, including sections on bread, cookies, cakes and muffins, pasta and noodles and many more including their packaging, preparation methods and ingredients. With this text researchers will find a comprehensive single source for information on the processing of cereal-based food products. Covers different types of products prepared from cereal grains; Focuses on production technology for the development of cereal products; Presents information on packaging requirements of cereal products.
    Type of Medium: Online Resource
    Pages: VIII, 369 p. 75 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031403088
    URL: https://doi.org/10.1007/978-3-031-40308-8
    DOI: 10.1007/978-3-031-40308-8
    DDC: 641.3
    Language: English
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    In a Class of Their Own : A Detailed Examination of Avian Forms and Functions (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Physiology. ; Anatomy. ; Ecology . ; Zoology. ; Behavior genetics. ; Animal Physiology. ; Anatomy. ; Ecology. ; Zoology. ; Behavioral Genetics.
    Description / Table of Contents: Chapter 1. Origin and Evolution of Birds -- Chapter 2. Skeleton and Skeletal Muscles -- Chapter 3. Integument -- Chapter 4. Nervous System -- Chapter 5. Locating, Ingesting, and Digesting Food -- Chapter 6. Cardiovascular and Immune Systems -- Chapter 7. Respiration -- Chapter 8. Endocrine System -- Chapter 9. Urinary System, Salt Glands, and Osmoregulation -- Chapter 10. Energy Balance and Thermoregulation -- Chapter 11. Avian Locomotion: Flying, Running, Walking, Climbing, Swimming, and Diving -- Chapter 12. Sound and Vocal Production and Function -- Chapter 13. Migration -- Chapter 14. Navigation and Orientation -- Chapter 15. Mating Systems -- Chapter 16. Avian Reproduction: Timing, Anatomy, and Eggs -- Chapter 17. Avian Reproduction: Nests and Nest Sites -- Chapter 18. Avian Reproduction: Clutch Sizes, Incubation, and Hatching -- Chapter 19. Avian Reproduction: Post-hatching Parental Care and Blood Parasitism.
    Abstract: With more than 10,000 species that vary in size, use diverse habitats that extend across latitudes and altitudes, consume a wide variety of food items, differ in how they fly (or not), communicate, and reproduce, and have different life histories, birds exhibit remarkable variation in form (anatomy) and function (physiology). Our understanding of how natural selection has generated this variation as birds evolved and as different species adapted to their unique circumstances has grown considerably in recent years. In In a Class of Their Own: A Detailed Examination of Avian Forms and Functions, this variation is explained in great detail, beginning with an overview of avian evolution and continuing with information about the structure and function of the avian skeleton, muscles, and the various body systems. Other chapters focus on avian locomotion (including flight), migration, navigation, communication, energy balance and thermoregulation, and various aspects of avian reproduction, such as nests and nest building, clutch sizes, and parental care. In a Class of Their Own: A Detailed Examination of Avian Forms and Functions will be must reading for anyone, professional or non-professional, who needs or wants to learn more about birds.
    Type of Medium: Online Resource
    Pages: XVII, 2506 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031148521
    Series Statement: Fascinating Life Sciences,
    URL: https://doi.org/10.1007/978-3-031-14852-1
    DOI: 10.1007/978-3-031-14852-1
    DDC: 571.1
    Language: English
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    Legumes Biofortification (2023)
    Cham :Springer International Publishing :
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    Keywords: Plant physiology. ; Plant molecular biology. ; Plant biotechnology. ; Plant genetics. ; Agriculture Economic aspects. ; Agronomy. ; Plant Physiology. ; Plant Molecular Biology. ; Plant Biotechnology. ; Plant Genetics. ; Agricultural Economics. ; Agronomy.
    Description / Table of Contents: Chapter. 1. Introduction to biofortification and challenges for nutrition security -- Chapter. 2. Nutritional Security Approaches for Legumes Bio fortification-A major Challenge -- Chapter. 3. Micronutrients enrichments in legumes through agronomic and cultural practices -- Chapter. 4. General aspects of genetic improvement (traditional and transgenic methods) aiming at Food Biofortification -- Chapter. 5. Contribution of Conventional Breeding Approaches in Legumes Biofortification -- Chapter. 6. Contribution of Biotechnological Approaches for Micronutrients Improvements in Legumes -- Chapter. 7. Nutritional enrichment in legumes through OMICs approaches -- Chapter. 8. How Genome Editing can be helpful in the Biofortification of Legume -- Chapter. 9. Transgenic Strategies and genome editing Towards Nutritional Enrichment -- Chapter. 10. Biofortification of Legume Hybrids Obtained Through Intergeneric Hybridization -- Chapter. 11. The Importance of Plant Growth-Promoting Rhizobacteria in The Biofortification of Legumes -- Chapter. 12. Plant-microbe interaction for legume bio-fortification: Present status and future challenges -- Chapter. 13. Improving iron nutrition in legumes to overcome hidden hunger -- Chapter. 14. Bio-fortification of zinc in legumes to alleviate the zinc deficiency -- Chapter. 15. Organic approaches towards iron and zinc biofortification in legume Crops -- Chapter. 16. Legumes Biofortification for Selenium Contents -- Chapter. 17. Iodine biofortification of legumes -- Chapter. 18. Enriching Legumes Protein Contents and Essential Amino Acid -- Chapter. 19. Enriching legume protein contents -- Chapter. 20. Bio-molecular Aspects of Plant Nutrition Related to Food Biofortification -- Chapter. 21. Medicinal legumes in Turkey: a gift of nature for bios -- Chapter. 22. Variability in the biofortification properties of fenugreek (Trigonella foenum-graecum L.) -- Chapter. 23. Biofortification: Lesson from the Past and Strategies for Future Food Security.
    Abstract: Sustainable food production is vital to ensure food and nutritional security to growing human population. Recently, there has been a shift in agricultural production system, crop production is not only considering yield as primary interest to produce higher number of calories for reducing hunger, but also more nutrient-rich food to reduce malnutrition or “hidden hunger”. Micronutrient malnutrition is a continuing and serious public health problem in many countries, various Interventions to alleviate this problem have been implemented. Biofortification, the process of breeding nutrients into food crops, provides a comparatively cost effective, sustainable, and long-term means of delivering more micronutrients. Legumes have higher protein content than most plant foods approximately twice than cereals and are rich in the key micronutrients folate, niacin, thiamine, calcium, iron and zinc. This book summarizes the biofortification of legumes. Detailed information through contributed chapters shed light on legumes research relevant to human health, with key topics that include genomic and genetic resources for food security, conventional and modern breeding approaches for improving nutrition, agronomic traits and biotechnological interventions.
    Type of Medium: Online Resource
    Pages: XVI, 549 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031339578
    URL: https://doi.org/10.1007/978-3-031-33957-8
    DOI: 10.1007/978-3-031-33957-8
    DDC: 571.2
    Language: English
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    The Lymnaeidae : A Handbook on Their Natural History and Parasitological Significance (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Invertebrates. ; Parasitology. ; Veterinary medicine. ; Paleontology . ; Freshwater ecology. ; Marine ecology. ; Evolution (Biology). ; Invertebrate Zoology. ; Parasitology. ; Veterinary Science. ; Paleontology. ; Freshwater and Marine Ecology. ; Evolutionary Biology.
    Description / Table of Contents: Chapter 1. A Brief History of the Lymnaeid Research -- Chapter 2. General Characteristics of the Family Lymnaeidae -- Chapter 3. Phylogeny and Taxonomy of the Family Lymnaeidae -- Chapter 4. Conchological and Anatomical Identification of the Lymnaeid Snails -- Chapter 5. Molecular Techniques for the Study of Ecological and Evolutionary Processes in Lymnaeids -- Chapter 6. The Fossil Record of the Lymnaeidae – Revisiting a 200-myr-Long Story of Success -- Chapter 7. Biogeography of the Living Lymnaeidae -- Chapter 8. Patterns and Processes of Speciation in Lymnaeidae -- Chapter 9. Ecology of Lymnaeid Snails -- Chapter 10. Reproductive Strategies, Genetic Diversity, and Invasive Ability in Lymnaeidae -- Chapter 11. Biology of the Lymnaeidae–Parasite Interaction -- Chapter 12. Overview of Interactions Between Parasitic Digenea and Their Molluscan Hosts, with Special Emphasis on the Lymnaeidae -- Chapter 13. Lymnaeid Snails and the Transmission of Fasciolosis: Understanding the Differential Risks from Local to Global Scale -- Chapter 14. Laboratory Cultures of Lymnaeidae for Parasitological Experiments -- Chapter 15. Control of Fasciolosis-Transmitting Lymnaeids in the Field -- Chapter 16. Conservation of the Lymnaeidae -- Chapter 17. Perspectives: An Integrated Approach on Future Studies of the Lymnaeidae.
    Abstract: The Lymnaeidae (also known as ‘pond snails’) are a species-rich and globally distributed family of freshwater snails, many species of which are known to be hosts of parasitic trematodes (such as the liver fluke, Fasciola hepatica). Written by world-leading experts in the field, this book covers a wealth of topics ranging from the phylogeny and taxonomy of lymnaeid snails to their relationships with helminths and their impact on public and veterinary health. It provides an overview of the species richness, evolution, ecology, biogeography and fossil record of the family. A considerable number of chapters are devoted to the economic and medical importance of lymnaeids, their involvement in the transmission of fascioliasis and other zoonotic diseases. Special chapters deal with the molecular and morphological identification of the Lymnaeidae, their rearing in the laboratory and experimental approaches to their study. This contributed volume is aimed at experts and practitioners in various disciplines: Invertebrate zoology, evolutionary biology, biogeography, aquatic ecology, parasitology, epidemiology and public health. It is also useful for university lecturers, undergraduate and postgraduate students.
    Type of Medium: Online Resource
    Pages: XIII, 477 p. 73 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031302923
    Series Statement: Zoological Monographs, 7
    URL: https://doi.org/10.1007/978-3-031-30292-3
    DOI: 10.1007/978-3-031-30292-3
    DDC: 592
    Language: English
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    Cancer Epigenetics (2023)
    Cham :Springer International Publishing :
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    Keywords: Epigenetics. ; Cancer Genetic aspects. ; Medicinal chemistry. ; Epigenetics. ; Cancer Genetics and Genomics. ; Medicinal Chemistry.
    Description / Table of Contents: Part-1. Background -- Chapter 1. An Overview of Epigenetics Modifications in Normal and Cancer Cell -- Chapter 2. Epigenetic Enzymes and Mutation of Epigenetic Enzymes -- Chapter 3. Introduction to Cancer Epigenetics -- Part II. Cancer Specific Epigenetic Alterations -- Chapter 4. Epigenetics in the Diagnosis, Prognosis and Therapy of Cancer -- Chapter 5. The Clinical Studies and Epi-Drugs In Various Cancer Types -- Chapter 6. Epigenetic Regulation in Breast Cancer Tumor Microenvironment -- Chapter 7. The Epigenetics Of Brain Tumors: Fundamental Aspects Of Epigenetics In Glioma -- Chapter 8. Epigenetic Alterations in Pancreatic Cancer -- Chapter 9. Current Preclinical Applications of Pharmaco-Epigenetics in Cardiovascular Diseases -- Chapter 10. Epigenetic Alterations in Colorectal Cancer -- Chapter 11. Epigenetic Alterations in Hematopoietic Disorders.
    Abstract: Epigenetic alterations are heritable changes that play a key role in human development and tissue-specific gene expression patterns. These changes can lead to alterations involved in tumor formation, imprinting, and metabolic disorders. Recent advances can help us understand the importance of epigenetic changes in both cancer development and tumor progression. In addition, epigenetic alterations may also be useful diagnostic and prognostic markers for the analysis of tumor progression. Split into two parts, the book opens with a comprehensive overview of the identification and analysis of epigenetic changes in cancer and the consequences of such changes during tumor development. The second part focusses on cancer specific epigenetic alterations and discusses the potential use of epigenetic markers as biomarkers in diagnosis, early cancer progression, and prognosis. Moreover, it reviews the therapeutic potential of epigenetic drugs. Given its scope, Cancer Epigenetics is an indispensable resource not only for researchers working in the field of human epigenetics and cancer research but also for advanced students seeking for an introduction into epigenetic mechanisms. .
    Type of Medium: Online Resource
    Pages: XXII, 378 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031423659
    Series Statement: Epigenetics and Human Health, 11
    URL: https://doi.org/10.1007/978-3-031-42365-9
    DOI: 10.1007/978-3-031-42365-9
    DDC: 572.865
    Language: English
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    Coral Reefs of Cuba (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Ecology . ; Oceanography. ; Conservation biology. ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Biooceanography. ; Conservation Biology.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Insights from Cuban Coral Reefs -- Part II. History -- Chapter 2. Research History of Corals and Coral Reefs in Cuba -- Part III. Description -- Chapter 3. Physical-Geographic Characteristics of Cuban Reefs -- Chapter 4. Outline of the Geology, Geomorphology and Evolution of the Late Qua-ternary Shelf and Uplifted Marine Terraces of Cuba; Tectonic and Sea Level Control of Present Day Coral Reef Distribution -- Chapter 5. A Remote Sensing Appraisal of the Extent and Geomorphological Diversity of the Coral Reefs of Cuba -- Part IV. Biota -- Chapter 6. Macrophytes Associated with Cuban Coral Reefs -- Chapter 7. Sponges: Conspicuous Inhabitants of the Cuban Coral Reefs and Their Potential as Bioindicators of Contamination -- Chapter 8. Species List of Cuban Stony Corals: Class Anthozoa, Order Scleractinia; Class Hydrozoa, Suborders Capitata and Filifera -- Chapter 9. Octocoral Forests: Distribution, Abundance, and Species Richness in Cuban Coral Reefs -- Chapter 10. Current State of Knowledge of Reef Mollusks in Cuba -- Chapter 11. Herbivory on Cuban Coral Reefs -- Chapter 12. Chronology of the Lionfish Invasion in Cuba and Evaluation of Impacts on Native Reef Fishes -- Chapter 13. Sharks and Rays in Cuban Coral Reefs: Ecology, Fisheries, and Conservation -- Chapter 14. Mesophotic Coral Ecosystems of Cuba -- Part V. Ecology, Conservation and Management -- Chapter 15. Status of Cuban Coral Reefs -- Chapter 16. Population Genetics of Cuba’s Scleractinian Corals -- Chapter 17. Multiple Cumulative Effects on Coral Reefs of the Northwestern Cuban Region -- Chapter 18. Guanahacabibes National Park: Research, Monitoring and Man-Agement for the Conservation of Coral Reefs -- Chapter 19. Ciénaga de Zapata Biosphere Reserve: Integrating Science with the Management of Coral Reefs -- Chapter 20. Coral Reefs in Cuban Marine Protected Areas -- Part VI. Economic Valuation -- Chapter 21. Economic Valuation of the Coral Reefs of Jardines de la Reina and Punta Francés National Parks, Cuba -- Chapter 22. The Economic Value of Coral Reefs in the Context of Marine Protected Areas: Experiences of the South Cuban Archipelago Project -- Chapter 23. Fish Can Be More Valuable Alive Than Dead.
    Abstract: This comprehensive volume gathers foremost experts on the coral reefs of Cuba who represent a spectrum of disciplines, including biology, conservation ecology, economics and geology. The volume is organized along general themes including the Cuban Reef biota, reefs occurring in the Mesophotic and Eutrophic zones, ecology, conservation, management and the economic importance of the coral reefs of Cuba. The combination of case studies, new and previously published research, historical overview and examples of the ways in which research has contributed to the management and conservation of Cuban coastal resources provides a unique reference for graduate students and professionals holding a wide range of interests and expertise related to coral reef systems.
    Type of Medium: Online Resource
    Pages: XI, 438 p. 176 illus., 147 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031367199
    Series Statement: Coral Reefs of the World, 18
    URL: https://doi.org/10.1007/978-3-031-36719-9
    DOI: 10.1007/978-3-031-36719-9
    DDC: 577.6
    Language: English
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    Principles of Microbial Metabolism and Metabolic Ecology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Life sciences. ; Microbial ecology. ; Industrial microbiology. ; Microbial genetics. ; Microbiology. ; Life Sciences. ; Microbial Ecology. ; Industrial Microbiology. ; Microbial Genetics.
    Description / Table of Contents: Microbial Life on Earth, Metabolism, and Metabolic Diversity -- A Microbe’s Environment and Natural Selection -- Microbial Energetics -- Catabolism and Its Coupling to Anabolism -- Microbial Kinetics -- Mechanisms of Microbial Energy Conservation -- Prototypic Reactions of Prokaryotic Carbon Catabolism -- Metabolic Modules, Pathways, and Nodes of Intermediates -- Fermentative Metabolism -- Prototypic Reactions, Modules, and Pathways of C1 Catabolism.
    Abstract: This textbook examines the fundamental principles of microbial metabolism and how a microbe's ecology is intrinsically interwoven with and a consequence of its metabolism. Further, it answers many questions frequently asked by students, such as: What are the mechanistic connections between simple phenotypic traits, ecological patterns and microbial metabolism and diversity? In the process, readers will be introduced to essential topics like metabolism and metabolic pathways, flux of energy and nutrients, genome size and fitness, competition, selection and drift. Moreover, the book conveys fundamental principles that show students how to approach the field of microbiology from a different, more unifying angle, e.g., how microbes’ access to environmentally available energy resources and the specific metabolism involved lies at the root of every ecologically significant microbial speciation. This aspect, together with its special focus on metabolism and ecological implications, make the book a must-read for all students of microbiology.
    Type of Medium: Online Resource
    Pages: XVII, 338 p. 198 illus., 165 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031282188
    URL: https://doi.org/10.1007/978-3-031-28218-8
    DOI: 10.1007/978-3-031-28218-8
    DDC: 579
    Language: English
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  • 97
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    Cold-Water Coral Reefs of the World (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Ecology . ; Oceanography. ; Bioclimatology. ; Environmental management. ; Freshwater and Marine Ecology. ; Biodiversity. ; Biooceanography. ; Climate Change Ecology. ; Environmental Management. ; Ocean Sciences.
    Description / Table of Contents: Chapter 1. A Global View of the Cold-Water Coral Reefs of the World -- Chapter 2. Biology, Ecology and Threats to Cold-Water Corals on Brazil’s Deep-Sea Margin -- Chapter 3. Cold-Water Corals of the World: Gulf of Mexico -- Chapter 4. Cold-Water Coral Reefs of the Southeastern United States -- Chapter 5. Norwegian Coral Reefs -- Chapter 6. Waters of Ireland and the UK -- Chapter 7. Life and Death of Cold-Water Corals across the Mediterranean Sea -- Chapter 8. Cold-Water Coral Reefs in the Oxygen Minimum Zones off West Africa -- Chapter 9. New Zealand: South West Pacific Region -- Chapter 10. Deep-Sea Corals of the North and Central Pacific Seamounts.
    Abstract: Cold-water corals form reef structures in continental margin and seamount settings world-wide, making them more wide-spread and abundant than shallow-water reefs. Their role in these ecosystems is no less important than the influence that shallow-water coral reefs have on tropical systems. They create habitat structure, host endemic species, enhance elemental cycling, alter current flow, sequester carbon, and provide many other ecosystem services that we are just beginning to understand. The rapidly evolving state of knowledge of cold-water and deep-sea coral reefs has not been compiled in over 10 years. This volume synthesizes recent and historical information, reveals new findings from reefs that have been discovered only recently, and presents key avenues for future research. We are on the cusp of understanding the critical role that cold-water coral reefs play in the world’s oceans, and this book lays the foundation on which this knowledge will be built in the future.
    Type of Medium: Online Resource
    Pages: XVI, 293 p. 107 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031408977
    Series Statement: Coral Reefs of the World, 19
    URL: https://doi.org/10.1007/978-3-031-40897-7
    DOI: 10.1007/978-3-031-40897-7
    DDC: 577.6
    Language: English
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    Sustainable Use of Feed Additives in Livestock : Novel Ways for Animal Production (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Veterinary medicine. ; Physiology. ; Agriculture. ; Veterinary Science. ; Animal Physiology. ; Agriculture.
    Description / Table of Contents: Part I. Introductory Chapters and Historical Abstract -- Feed Additives to Ensure Sustainability -- Feed Additives, Their Role and Technological Properties -- Food Additives as Functional Ingredients in Food Products -- History of Feed Additives -- Part II. Sources and Types of Feed Additives -- Enzymes as Feed Additives -- Medicinal and Aromatic Plants as a Source of Potential Feed and Food Additives -- The Role of Insects in Novel Sustainable Animal Production Systems -- Probiotics, Prebiotics, Paraprobiotics, Postbiotics -- Novel Plant Extracts as Food Additives -- The Use of Feed and Food Additives in USA -- Part III: Biochemistry and General Effects -- The Effects of Feed Additives on Farm Animals under Heat Stress Conditions -- Feed Additives as Antiviral Agents -- Food and Feed Additives to Counteract Mycotoxin Toxicity in Human and Animals -- Part IV. Specific Applications in Livestock by Animal Groups -- Plant-Based Feed Additives for Livestock and Poultry in Southern Africa -- Plant-Based Feed Additives for Livestock and Poultry in Southern Africa -- Feed Additives to Combat Intestinal Diseases in Antibiotic Free Poultry Farming -- The Effects of Feed Additives on the Immune System of Poultry -- Application of Aromatic Plants and Their Extracts in Livestock -- Improving the Sustainability of Laying Hen Production Using Plant-Based Feed Additives -- Application of Feed Additives in the Diets of Turkeys -- Effect of Phytochemical Feed Additives on Health Status, Milk Yield and Quality Characteristics in Ruminants -- Feed Additives as Dietary Tools to Improve Welfare Status in Ruminants -- Application of Feed Additives to Improve Pork Meat Quality -- Feed additives, as Dietary Tools to Support Gut Health of Pigs -- Feed Additives as Immune Boosting Factors in Swine Health -- Probiotics as Feed Additives in Monogastric Animals -- Feed Additives for Insect Production -- Feed Additives in Aquaculture -- Certain Major Diseases Having Nutritional Disorders in Their Etiology and Economic Importance in Horses -- Feed Additives in Rabbit Nutrition to Ensure Sustainability -- Part V: Analytical Methods, Future Outlook and Perspectives -- Modern Applications in the Determination of Food and Feed Additives -- Antimicrobials as Feed and Food Additives, Their Technological Properties and Perspectives -- Feed Additives and Future Perspectives.
    Abstract: This book offers a comprehensive collection of cutting-edge research on feed additives for a sustainable animal production, including insects and aquaculture. In five clearly structured sections, the sources of feed additives, details on their biochemistry, feed security as well as specific applications for individual farm animal species, livestock health and product characteristics (meat, milk and eggs) find attention. International expert authors provide a full description on the use of aromatic plants, extracts and essential oils as feed additives alone or in combination with functional feeds of different categories. Readers will explore the potential of feed additives to tackle environmental issues. Practical examples include the use of local feedstuffs in combination with herbal additives and enzymes. Emphasis is placed on the consequences of using local feed sources versus imported feedstuffs on global warming potential, primary energy use, nutrient excretion and the feed additive influence on lessening the pollution from animal operations. The results presented will support realization of the Sustainable Development Goals, in particular SDG 12 which stands for Responsible Consumption and Production worldwide. The use of novel and different feed additives can be an important tool to enhance sustainability, support productivity, and match increased food demands around the globe. Animal production depends on feed efficiency to sustain growth and profitability. Along these lines, the present volume is an essential reading for all future-oriented veterinarians, animal nutritionists, agricultural scientists, and moreover the feed, food and plant industry. .
    Type of Medium: Online Resource
    Pages: XIV, 969 p. 60 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031428555
    URL: https://doi.org/10.1007/978-3-031-42855-5
    DOI: 10.1007/978-3-031-42855-5
    DDC: 636.089
    Language: English
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    Polystomatid Flatworms : State of Knowledge and Future Trends (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Parasitology. ; Veterinary medicine. ; Zoology. ; Ecology . ; Evolution (Biology). ; Parasitology. ; Veterinary Science. ; Zoology. ; Ecology. ; Evolutionary Biology.
    Description / Table of Contents: Chapter 1. Overview of the Polystomatidae: Systematics and Classification -- Chapter 2. Contributions to the History of Polystomatid Flatworm Discoveries and Research -- Chapter 3. Collecting and Processing Polystomatid Flatworms -- Chapter 4. Polystome Species of Amphibians -- Chapter 5. Polystome Species of the Australian Lungfish, Chelonians and the Common Hippopotamus -- Chapter 6. Polystomatidae: Life-History Strategies, the Key to Success -- Chapter 7. Insights into the Origin and Evolution of the Polystomatidae -- Chapter 8. Poystomatid Studies: Future Prospects.
    Abstract: This unique book offers a comprehensive guide to the fascinating world of polystomatid flatworms. It introduces the reader to the individual life histories of polystomes and the chronological advances in our knowledge, with descriptions of species discovered over the past centuries. It equips newcomers to the field with basic protocols and techniques for collecting, processing and interpreting material. It also presents the history of research on this group of parasites, provides information on the discovery of each polystome and acknowledges the authors that have made major contributions. For the established researcher in the field, it offers a reference book containing taxonomic data, measurements and drawings of all known polystomes. The authors have brought together all the available material, creating a resource that will stimulate research and revive the global focus on this unique group of parasites. Thus, this work provides an essential reference for both established researchers and newcomers to the field.
    Type of Medium: Online Resource
    Pages: XVII, 645 p. 250 illus., 246 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031358876
    Series Statement: Zoological Monographs, 9
    URL: https://doi.org/10.1007/978-3-031-35887-6
    DOI: 10.1007/978-3-031-35887-6
    DDC: 571.999
    Language: English
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    Virus Infected Cells (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Clinical biochemistry. ; Diseases Causes and theories of causation. ; Microbiology. ; Molecular biology. ; Biology Technique. ; Virology. ; Medical Biochemistry. ; Pathogenesis. ; Microbiology. ; Molecular Biology. ; Biological Techniques.
    Description / Table of Contents: Part 1: General / Technical Aspects -- Chapter 1: In Situ Imaging Of Virus Infected Cells By Cryo-Electron Tomography: An Overview -- Chapter 2: Approaches To Evaluating Necroptosis In Virus Infected Cells -- Chapter 3: Apoptosis And Phagocytosis As Antiviral Mechanisms -- Chapter 4: The Art Of Viral Membrane Fusion And Penetration -- Chapter 5: Single Particle Tracking Of Virus Entry In Live Cells -- Chapter 6: Correlative Cryo-Imaging Using Soft X-Ray Tomography For The Study Of Virus Biology In Cells And Tissues -- Chapter 7: The Virus-Induced Cytopathic Effect -- Part 2: Specific Viruses -- Chapter 8: Human Papilloma Virus-Infected Cells -- Chapter 9: Defining The Assembleome Of The Respiratory Syncytial Virus -- Chapter 10: Japanese Encephalitis Virus Infected Cells -- Chapter 11: African Swine Fever Virus Host-Pathogen Interactions -- Chapter 12: Coronavirus And The Cytoskeleton Of Virus-Infected Cells -- Chapter 13: Viral Rna Is A Hub For Critical Host-Virus Interactions -- Chapter 14: Influenza A Virus: Cellular Entry -- Chapter 15: Human Endogenous Retroviruses In Diseases -- Chapter 16: Cholesterol And M2 Rendezvous In Budding And Scission Of Influenza A Virus.
    Abstract: Virus-infected Cells is a comprehensive and technical exploration of the intricate interactions between viruses and host cells. This book delves into the molecular and cellular aspects of viral infections, providing a wealth of knowledge about various viruses and their effects on cellular mechanisms. The first part of the book covers general/technical aspects, introducing the reader to the field of virology and providing an overview of the techniques used to study virus-infected cells. It covers topics such as the visualisation of virus-infected cells by cryo-electron tomography and the assessment of necroptosis, a type of programmed cell death, in virus-infected cells. In addition, the book explores the role of apoptosis and phagocytosis as antiviral mechanisms, as well as the intricate process of viral membrane fusion and penetration. It also discusses the tracking of viral entry into living cells and the use of correlative cryo-imaging to study the biology of viruses in cells and tissues. Finally, the book examines the cytopathic effect induced by viruses, shedding light on the damage caused to infected cells. The second section of the book explores specific viruses and their interactions with host cells. Each chapter focuses on a specific virus and provides an in-depth look at its behaviour within infected cells. The book covers a wide range of viruses, including human papillomavirus, respiratory syncytial virus, Japanese encephalitis virus, African swine fever virus, coronavirus, influenza A virus and human endogenous retroviruses. Each chapter examines unique aspects of virus-host interactions, such as viral assembly, impact on the cytoskeleton, critical host-virus interactions mediated by viral RNA, mechanisms of cell entry, and the involvement of cholesterol in virus budding and scission. This volume in the Subcellular Biochemistry series is a valuable resource for researchers, virologists and students interested in understanding the complex dynamics between viruses and the cells they infect. With its detailed exploration of general and specific aspects of virus-host interactions, this book provides a comprehensive understanding of the molecular and cellular mechanisms involved in viral infections.
    Type of Medium: Online Resource
    Pages: VIII, 459 p. 70 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031400865
    Series Statement: Subcellular Biochemistry, 106
    URL: https://doi.org/10.1007/978-3-031-40086-5
    DOI: 10.1007/978-3-031-40086-5
    DDC: 579.2
    Language: English
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