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  • Books  (189)
  • Medical genetics  (93)
  • thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences  (75)
  • Cell & Developmental Biology
  • Chemical Engineering
  • Humans
  • Inorganic Chemistry
  • Software Engineering
  • IntechOpen  (168)
  • Springer  (21)
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  • 1
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    Old Protein, New Medicine (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: As a member of the protein family known as neurotrophins, brain-derived neurotrophic factor (BDNF) plays a crucial role in supporting healthy brain function, which includes synaptic plasticity, cellular differentiation, learning, and the survival of nerve cells. Neuronal plasticity refers to the nervous system’s ability to adapt and respond to environmental conditions, involving various structural and functional mechanisms that can lead to changes in neural circuits, the formation of new synapses, and the generation of fresh neurons. BDNF has emerged as a significant regulator of neuronal plasticity. It is worth noting that the pathophysiological processes underlying central nervous system disorders and neuropsychiatric conditions such as depression, anxiety, autism, and schizophrenia, as well as neurodegenerative diseases like Parkinson’s and Alzheimer’s, are influenced by BDNF. Due to its robust neuroprotective properties and recently discovered anti-inflammatory and anti-apoptotic characteristics, BDNF has long been considered a potential candidate for preventing neurodegeneration. In the context of autism spectrum disorder, BDNF holds great promise as a central focus for therapeutic efforts. Its significance extends to the field of spinal cord injury, where it assumes a multifaceted role in the intricate pathophysiological processes at play. BDNF functions as a catalyst for the growth of axons, a crucial step in the restoration of the nervous system following damage. In the context of sepsis, research into the potential of BDNF’s anti-inflammatory properties to mitigate organ damage is quite noteworthy. Additionally, current findings suggest that combining exercise with vitamin D may offer a promising approach to increase BDNF levels and improve brain health. This book presents comprehensive information on BDNF and its role in promoting neuroprotection. The chapters offer insights into recent developments, molecular principles, and innovative therapeutic approaches for neurodegenerative disorders and brain health.
    Keywords: bdnf ; inflammation ; oxidative stress ; biomarker ; sepsis ; ketamine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 2
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    Topics in Autonomic Nervous System (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The nervous system is an essential component of the human body and is divided into two main systems: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord and acts as the command center of the organism. The PNS is a network of nerves that extends from the spinal cord throughout the body and regulates both voluntary and involuntary movements, such as digestion, heart rate, breathing, and body temperature. Within the PNS, there are two subdivisions: the somatic nervous system and the autonomic nervous system. The somatic system controls voluntary movements, while the autonomic system operates automatically and regulates essential involuntary functions like heart rate and digestion. It is further divided into two branches, the sympathetic and parasympathetic systems, which work together to maintain homeostasis. Alterations in the autonomic nervous system can lead to various diseases, as these two branches play a crucial role in regulating the organs and systems of the body. For example, an imbalance in the sympathetic system can result in excessive heart rate and blood pressure, while a dysfunction in the parasympathetic system can lead to digestive problems. Therefore, understanding its divisions and functions is essential for the diagnosis and treatment of diseases caused by autonomic nervous system dysfunction. This book provides a comprehensive overview of this system and its functions.
    Keywords: physiology ; pain ; cancer ; diabetes mellitus ; melatonin ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 3
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    Acetylcholine (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Acetylcholine - Recent Advances and New Perspectives describes research related to the neurotransmitter acetylcholine. Acetylcholine was discovered as a neurotransmitter about 100 years ago. Still, researchers around the world study this important signaling molecule in terms of its chemistry, biochemistry, function in the central and peripheral nervous system, and relevance for neurological disorders and diseases. This book focuses on the role of acetylcholine in individual nerve cells, neural circuits, and specific brain regions. In addition, the book illustrates acetylcholine from historical perspectives to technological advances, as well as the use of novel tools in health and disease, in various animal models and organisms. As an added benefit, chapters in the book describe acetylcholine in its relation to paraoxonase enzymes, acetylcholine esterase, neurotoxins, and organophosphorus compounds. Furthermore, this book provides an overview of the work that is being done on acetylcholine and highlights any gaps and areas that would benefit from further exploration. It is a useful resource for students and researchers in biological, chemical, medical, and history disciplines.
    Keywords: alzheimer’s disease ; neuroinflammation ; chronic diseases ; nervous system ; prefrontal cortex ; homology modeling ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 4
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    Autonomic Nervous System (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The autonomic nervous system is one of the most important involuntary control mechanisms that primarily controls and modulates the functions of the visceral organs. The book discusses some of the specificities of the autonomic nervous system in terms of dendritic development in the sympathetic compartment, as well as a detailed description of noradrenergic groups and their key role in the modulation of all antinociceptive and autonomic responses elicited by painful or threatening situations. In the book, only those cases are mentioned that are closely related to disorders or changes of function of the autonomic nervous system. This book can evoke interest in many researchers who want to use the information for the advancement of their research towards a better understanding of the autonomic regulatory mechanisms.
    Keywords: inflammation, sepsis, heart rate variability, analgesia, ischemia, arrhythmias ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 5
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    Serotonin (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.
    Keywords: oocyte, sperm, nervous system, inflammation, biomarkers, obesity ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 6
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    Huntington's Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, "Huntington's Disease - Core Concepts and Current Advances", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 7
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    Circadian Rhythm (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.
    Keywords: melatonin, chronobiology, circadian rhythms, stroke, cardiomyopathy, chagas disease ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 8
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    Proprioception (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Proprioception is the sense of body position and movement, with conscious and unconscious components, that determines and conditions the human body’s relationship with the environment. This quality of mechanosensitivity deteriorates in some pathologies and is responsible for some alterations of the locomotor system that appear in elderly persons. In those situations, the failure of proprioception reduces the quality of life of the subjects. The widespread use in developed countries of substitute joint prostheses makes it necessary to rethink the concepts of movement detection and perception. As such, this book examines the basics of proprioception as well as its function in the lower extremities, the head, in children with disabilities, and its connection with virtual reality.
    Keywords: virtual reality, neuroplasticity, ion channels, neurology, electromyography, orthopedics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 9
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    Autonomic Nervous System (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The autonomic nervous system (ANS) is a subsystem of the nervous system that possesses several levels (groups) for receiving, transmitting, generating, and processing information. This book presents a comprehensive overview of the ANS, including chapters on the role of the ANS in a healthy lifestyle, the ANS–stress relationship, general anesthesia and the ANS, signaling pathways, and more.
    Keywords: Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 10
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    Recent Advances in Cannabinoid Research (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Scientific interest in cannabinoid research is currently experiencing a significant increase because of changing attitudes toward Cannabis and the evolving awareness of its pharmaceutical benefits. Coincidently, numerous jurisdictions are moving toward legalizing Cannabis and Cannabis-derived products, which reflects a larger global movement to understand Cannabis and its bioactive chemicals for their potential biomedical uses, harms, and economic value. Research activities are surging to fill important knowledge gaps in the field of cannabinoids as they continue to be identified. The purpose of this book is to summarize some leading areas of research in the cannabinoid field where knowledge gaps are actively being addressed. The research described herein spans basic biological and clinical research.
    Keywords: epilepsy, pain, addiction, terpenes, cannabinoids, cannabis ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 11
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    Cognitive and Computational Neuroscience (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The book "Cognitive and Computational Neuroscience - Principles, Algorithms and Applications" will answer the following question and statements: System-level neural modeling: what and why? We know a lot about the brain! Need to integrate data: molecular/cellular/system levels. Complexity: need to abstract away higher-order principles. Models are tools to develop explicit theories, constrained by multiple levels (neural and behavioral). Key: models (should) make novel testable predictions on both neural and behavioral levels. Models are useful tools for guiding experiments. The hope is that the information provided in this book will trigger new researches that will help to connect basic neuroscience to clinical medicine.
    Keywords: surveillance, inverse model, reverse engineering, behavior, forward model ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 12
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    Genetic Diversity in Microorganisms (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Genetic Diversity in Microorganisms presents chapters revealing the magnitude of genetic diversity of microorganisms living in different environmental conditions. The complexity and diversity of microbial populations is by far the highest among all living organisms. The diversity of microbial communities and their ecologic roles are being explored in soil, water, on plants and in animals, and in extreme environments such as the arctic deep-sea vents or high saline lakes. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in microorganisms. The purpose of the book is to provide a glimpse into the dynamic process of genetic diversity of microorganisms by presenting the thoughts of scientists who are engaged in the generation of new ideas and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of microbial phylogeny, genetic diversity, and molecular biology.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 13
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    Child and Adolescent Mental Health (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: In the present volume, we collected state-of-the-art chapters on diagnosis, treatment, and social implications. The first section describes diagnostic processes. It describes a reevaluation of projective techniques, a new clinical tool in psychotraumatology, the foundations of the framing technique, and an overview on integrative approaches. The second section focuses on new developments in the field with special emphasis on culture-specific contexts. From parenting of adolescents in India to the influence of poverty on mental health issues in Mexico, as well as the use of marijuana and Internet addiction, some of the most important fields are highlighted. The third section concentrates on therapy. It shows how to react to bullying and reviews the use of antidepressants in children and adolescents.
    Keywords: adolescents, epidemiology, trauma, poverty, earthquake, mindfulness ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 14
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    New Developments in Anxiety Disorders (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book collects the contribution of a selected number of clinical psychiatrists, interested in the clinical application of some aspects of neurobiology of anxiety. The seven chapters of the book address some issues related to the latest acquisitions of neurobiology, in particular those aspects that are related to responses to treatment - both psychological and pharmacological. Some chapters are also dedicated to the comorbidities, a rule rather than an exception when it comes to anxiety. Each author summarized the clinical importance of his work, underlining the clinical pitfalls of this new book on anxiety.
    Keywords: comorbidity, genetics, pharmacology, social media, gaba, psychotherapy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 15
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    DNA Replication (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 16
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    Gene Duplication (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The book Gene Duplication consists of 21 chapters divided in 3 parts: General Aspects, A Look at Some Gene Families and Examining Bundles of Genes. The importance of the study of Gene Duplication stems from the realization that the dynamic process of duplication is the “sine qua non” underlying the evolution of all living matter. Genes may be altered before or after the duplication process thereby undergoing neofunctionalization, thus creating in time new organisms which populate the Earth.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 17
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    Synaptic Plasticity (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Nerve cells form thousands of contact points, the synapses, to communicate information with other neurons and target cells. Synapses are sites for changes in brain function through modification of synaptic transmission termed synaptic plasticity. The study of synaptic plasticity has flourished over the years with the advancement of technical breakthroughs and is a timely scientific endeavor today just like it was several decades ago. This book contributes to our understanding of synaptic plasticity at the molecular, biochemical, and cellular systems and behavioral level and informs the reader about its clinical relevance. The book contains ten chapters in three sections: (1) "Mechanisms of Synaptic Plasticity," (2) "Neural Plasticity," and (3) "Plasticity and Neurological Diseases." The book provides detailed and current reviews in these different areas written by experts in their respective fields. The mechanisms of synaptic plasticity and its relation to neurological diseases are featured prominently as a recurring theme throughout most chapters. This book will be most useful for neuroscientists and other scientists alike and will contribute to the training of current and future students who find the plastic nervous system as fascinating as many generations before them.
    Keywords: cognition, creb, epilepsy, microrna, neuroprotection, stem cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 18
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    Gut Microbiota (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The gut-brain axis has gained considerable attention from different branches of the scientific community in recent years. In this book, scientists from different disciplines present current scientific knowledge on the topic. The interaction between the prokaryote and eukaryote cells stimulates the evolutionary processes, and results in various systemic illnesses such as neuropsychiatric disorders and may help the continuity of health. Nature has provided us with healthy food that builds our pharmacy. This natural pharmacy store may help the body's healing processes through its effects on gut microbiota and the immune system. This book aims to provide the reader with detailed analyses of the current scientific knowledge on the gut-brain axis and its relation with health and disease. We hope that the reader benefits from the presented material.
    Keywords: nutrition, probiotics, microbiome, gut-brain axis, inflammation, alzheimer’s disease ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 19
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    Genetic Transformation (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Genetic transformation of plants has revolutionized both basic and applied plant research. Plant molecular biology and physiology benefit from this power fool, as well as biotechnology. This book is a review of some of the most significant achievements that plant transformation has brought to the fields of Agrobacterium biology, crop improvement and, flower, fruit and tree amelioration. Also, it examines their impact on molecular farming, phytoremediation and RNAi tools.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 20
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    Event-Related Potentials and Evoked Potentials (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This edited volume Event-Related Potentials and Evoked Potentials is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of medicine and health sciences. The book comprises single chapters authored by various researchers and edited by an expert active in the field of event-related potential (ERP). An event-related potential (ERP) is the measured brain response that is the direct result of a specific sensory, cognitive, or motor event. Each chapter is complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in noninvasive means of evaluating brain functioning and opens new possible research paths for further novel developments.
    Keywords: multiple sclerosis, cognition, pathology, electroencephalogram, topography, brain-computer interface ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 21
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    Peripheral Nerve Regeneration (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
    Keywords: apoptosis, migration, injury, proliferation, carpal tunnel syndrome, adult neurogenesis ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Mechanisms of Neuroinflammation (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
    Keywords: alzheimer’s disease, cytokines, neurodegeneration, traumatic brain injury, psychiatric disorders, stroke ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 23
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    The Hippocampus (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
    Keywords: neurogenesis, spatial memory, cytokines, stress, gene expression, complexity ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Non-Viral Gene Therapy (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Autism Spectrum Disorder (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    The Amygdala (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Among the components of the limbic system, the amygdala is a fascinating structure that is involved in the processes of liking and disliking and in the ways our emotions drive our actions and affect the strength of our memories. Combined with new conceptual breakthroughs, the very latest data obtained by leading world experts in amygdala function that are reviewed in this book have helped to understand how the amygdala contribute to these processes and also to a variety of neurological and neuropsychiatric pathologies. Of course, due to the rate of research advancement, all the chapters presented here correspond to precise questions addressed by experts using highly specific techniques. Therefore, each chapter should be viewed as pieces of a puzzle that represent all the different research areas that have to be taken into consideration in discussing the role of the amygdala in emotion and memory. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in mechanisms underlying emotional learning and memory, we hope it will also help to stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Electroencephalography (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This edited volume Electroencephalography is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of medicine and health sciences. The book comprises single chapters authored by various researchers and edited by an expert active in the electrophysiological monitoring method research area. Each chapter is complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on electrophysiological monitoring method and opens new possible research paths for further novel developments.
    Keywords: eeg, motor learning, regression, hypothermia, inverse problem, ldpc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Update on Dementia (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    GABA And Glutamate (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.
    Keywords: mri, calcium, glioma, signal transduction, cns, neurological disorders ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Neurons (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The brain is the most complex structure that exists in the universe, consisting of neurons whose function is to receive information through dendrites and transmit information through the axon. In neurosciences one of the main problems that exists are neurodegenerative diseases for which until now there has been no cure. This book is mainly focused on updating the information on the signaling process carried out in the development of axons. Topics such as axon guidance and its interaction with the extracellular matrix are discussed. Other important topics are semaphorins and their relationship with neurodegenerative diseases, and the neurobiology of the gap junction in the dorsal root ganglion. Finally, the topic of bioelectrical interfaces destined to regenerate damaged nerves is covered. The information in this book will be very important both for researchers who work with these issues and doctoral students who are involved in neuroscience.
    Keywords: neurodegeneration, extracellular matrix, pain, neurodegenerative diseases, interface, stem cell ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Prefrontal Cortex (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The prefrontal cortex reaches its greatest development in the human brain, making up nearly one third of the neocortex. Due to its remarkable evolution, the prefrontal cortex plays an important role in higher integrative functions such as information processing, thinking, understanding, attention, behavior, motivation, emotions, working memory, and analysis. This book brings together theoretical and technical research advances on the prefrontal cortex, from the basic explanations of the neuronal architecture of the prefrontal cortex and its anatomy, presenting it as a morphological substrate for many psychological conditions, through normal and altered connectivity and its manifestation in different behavior and identification of organizational levels inside the prefrontal cortex through different neuroimaging methods. It also provides an interdisciplinary view of the prefrontal cortex and its issues and discovers the main role of this part of brain in psychosocial, economic, and cultural adaptation.
    Keywords: rehabilitation, neuroimaging, metacognition, schizophrenia, childhood, pragmatics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Advances in DNA Repair (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Physical Disabilities (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book, Physical Disabilities - Therapeutic Implications, presents reports on a wide range of areas in the field of neurobiological disabilities, including movement disorders (Uner Tan syndrome, genetic and environmental influences, chronic brain damage, stroke, and pediatric disabilities) related to physical and stem cell therapy. Studies are presented from researchers around the world, looking at aspects as wide-ranging as the genetics, wheelchair, and robotics behind the conditions to new and innovative therapeutic approaches.
    Keywords: rehabilitation, stroke, cerebral palsy, environment, autism, stem cell therapy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    High-Resolution Neuroimaging (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Dr. Ahmet Mesrur Halefoğlu mostly deals with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. He has served as postdoctoral research fellow at Johns Hopkins Hospital. Currently, he is working as an associate professor of radiology in Istanbul, Turkey. He has more than 50 high-impact-factor publications and has written 3 book chapters. He is a member of Turkish Society of Radiology and European Society of Radiology. During the recent years, there have been major breakthroughs in MRI due to developments in scanner technology and pulse sequencing. These important achievements have led to remarkable improvements in neuroimaging and advanced techniques, including diffusion imaging, diffusion tensor imaging, perfusion imaging, magnetic resonance spectroscopy, and functional MRI. These advanced neuroimaging techniques have enabled us to achieve invaluable insights into tissue microstructure, microvasculature, metabolism, and brain connectivity.
    Keywords: magnetic resonance imaging, mri, autism, tumor, prostate cancer, segmentation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Optic Nerve (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The optic nerve is a primary reference for those ophthalmologists and researchers interested in its anatomy and physiology, in the most recent diagnostic techniques, as well as in the clinical management of optic nerve disorders. The book provides a detailed description of the structure and functioning of the optic nerve and attempts at clarifying how anomalies in its development are related with tumor development. The book surveys the most recent diagnostic techniques, such as spectral domain optical coherence tomography, and highlights how these techniques can be employed to evaluate optic nerve layers as well as lesions compressing the visual pathway. Practical references to optic nerve drusen and the changes in the optic nerve due to diabetic retinopathy are also presented. The book is written in a concise fashion and aims at being a major reference to a broad audience, including students, ophthalmologist consultants, neurologists, researchers, and surgeons concerned with optic nerve diseases.
    Keywords: optical coherence tomography, diabetes mellitus, diabetic retinopathy, glioma, glaucoma, meningioma ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Neuroplasticity (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book provides comprehensive and up-to-date insights into emerging research trends on neuroplasticity with current or future treatments for neurodevelopment and neurodegenerative diseases. The authors discuss structural and functional changes associated with cortical remapping, sensory substitution, synaptic and non-synaptic compensatory plasticity due to brain damage, brain training, chronic pain, meditation, music, exercise and related states. Key features include pathogenesis, and existing and new therapies together with a pharmacological and non-pharmacological approach in clinical treatment and management. The authors are established experts that contributed significantly to a better understanding of the etiology of neuroplasticity. This book is recommended to healthcare providers, clinical scientists, students and patients.
    Keywords: multiple sclerosis, neurorehabilitation, parkinson’s disease, stem cells, transplantation, fatigue ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Evolving BCI Therapy (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: As a strategic response to cognitive and CNS impairments, BCI is a theoretical outgrowth of several generations of endogenous devices for peripheral nerves, which have as a prime goal the direct replacement of lost neural function. In these earlier applications therapeutic intervention has been premised only on the restoration of signal generating capacity where nerve transmission is largely unidirectional and temporally sequenced. It is increasingly apparent, however, that the brain not only employs a very different type of syntax from that of peripheral nerves but also structures the semantic content of motor activity, fundamentally altering the conception of BCI as a therapeutic medium. The book presented here documents this change, proposing a multi-faceted strategy in which BCI therapy can restore the loss of multi-tiered, brain based motor function.
    Keywords: eeg, motor imagery, neurorehabilitation, signal processing, autonomic nervous system, f-wave ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Alzheimer's Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.
    Keywords: inflammation, alzheimer’s disease, dementia, microglia, mild cognitive impairment, oxidative stress ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Hippocampus (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Ever since side effects from bilateral hippocampectomy were identified in Henry Molaison (patient “HM”) during the 1950s, a critical role of the hippocampus has been recognized in the formation of declarative episodic memories. Other cognitive functions have since been proposed, such as a role in navigation, but memory has often been suggested to explain hippocampal involvement. Proving a distinct functional role in cognition is difficult, as memory can be implicated in most cognitive activities. Even when a behavior relies on memory, however, the functionality of the hippocampus extends far beyond, especially evident during activities requiring interactions between cognitive systems. Relational memory is supported by hippocampal connections with widespread regions of the cortex; these interconnections also play a fundamental role in children’s writing abilities and expertise in musical performance. Besides enhancing individual lives, such activities can play a vital role in sustaining cultural values across generations. Interactions with the environment that do not directly depend on mnemonic activity can affect plasticity in hippocampal connections, modified through natural chemicals, pharmacological drugs, and non-pharmacological behaviors. Navigational properties of the hippocampal system are not limited to memory, containing the same navigational elements as our Global Positional System (GPS). Even cognitive deficits arising from hippocampal lesions in “HM” were not limited to memory, as they included deficits in understanding cognitive relationships available in visual scenes, novel sentence contexts, and humorous situations. This book shows an expansive role of the hippocampus in cognition that goes beyond its recognized role in generating new episodic memories.
    Keywords: alzheimer’s disease ; plasticity ; robotics ; neuroplasticity ; working memory ; acetylcholine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Viral Genomes (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Viruses are small infectious agents that can replicate only inside the living cells of susceptible organisms. The understanding of the molecular events underlying the infectious process has been of central interest to improve strategies aimed at combating viral diseases of medical, veterinary and agricultural importance. Some of the viruses cause dreadful diseases, while others are also of interest as tools for gene transduction and expression and in non-poluting insect pest management strategies. The contributions in this book provide the reader with a perspective on the wide spectrum of virus-host systems. They are organized in sections based on the major topics covered: viral genomes organization, regulation of replication and gene expression, genome diversity and evolution, virus-host interactions, including clinically relevant features. The chapters also cover a wide range of technical approaches, including high throughput methods to assess genome variation or stability. This book should appeal to all those interested in fundamental and applied aspects of virology.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Anal Incontinence (2022)
    Springer Nature | Springer
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    Publication Date: 2024-04-01
    Description: This open access book describes the latest advances in the anal incontinence diagnostic and therapeutic processes. Anal incontinence is a devastating condition heavily impacting on the patients’ lives. Those suffering from this disorder are generally very embarrassed and reluctant to undergo an appropriate clinical evaluation, thus becoming more isolated and worsening the quality of their life. Luckily, nowadays a wide range of treatments is available to improve this oppressive condition; however, the recognition of the related pathophysiological alterations is mandatory to grant its successful management. This volume will help the surgeons community to keep abreast of developments in diagnostics and treatment of this impairing condition. and will provide all health professionals with the appropriate tools to face this impairing condition.
    Keywords: Continence mechanism ; Fecal incontinence ; Pelviperineal disorders ; Anal sphincter ; Continence Surgery ; thema EDItEUR::M Medicine and Nursing::MN Surgery ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJH Gastroenterology ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJS Urology and urogenital medicine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology
    Language: English
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    Social and Affective Neuroscience of Everyday Human Interaction (2022)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-07
    Description: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Keywords: Social Cognition ; Clinical Neuroscience ; Moral Emotions ; Embodiment ; Social bonding ; Interpersonal Neuroscience ; Rapid Emotional Responses ; Mirror Neurons ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::J Society and Social Sciences
    Language: English
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    Mutagenesis and Mitochondrial-Associated Pathologies (2022)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Reactive oxygen species (ROS) and DNA double-strand breaks can result from mitochondrial defects and external sources, such as ionizing radiation. If not repaired properly, pathogenic mutations are generated. Human diseases resulting from inherited mitochondrial defects manifest in organs that physiologically require a high level of ATP synthesis. These diseases are clinically challenging, but new experimental clinical therapies include gene editing and mitochondrial transplants. Pathogenic ROS-associated cellular damage includes DNA double-strand breaks, and mouse models are now available to study multiple repair pathways. This book discusses the clinical manifestations of mitochondrial diseases in both the eye and the kidney, and presents new insights into double-strand break repair pathways and developmental phenotypes of g-ray-associated ontogenic mutations of Drosophila melanogaste.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Ernst Denert Award for Software Engineering 2020 (2022)
    Springer Nature | Springer
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    Publication Date: 2024-04-14
    Description: This open access book provides an overview of the dissertations of the eleven nominees for the Ernst Denert Award for Software Engineering in 2020. The prize, kindly sponsored by the Gerlind & Ernst Denert Stiftung, is awarded for excellent work within the discipline of Software Engineering, which includes methods, tools and procedures for better and efficient development of high quality software. An essential requirement for the nominated work is its applicability and usability in industrial practice. The book contains eleven papers that describe the works by Jonathan Brachthäuser (EPFL Lausanne) entitled What You See Is What You Get: Practical Effect Handlers in Capability-Passing Style, Mojdeh Golagha’s (Fortiss, Munich) thesis How to Effectively Reduce Failure Analysis Time?, Nikolay Harutyunyan’s (FAU Erlangen-Nürnberg) work on Open Source Software Governance, Dominic Henze’s (TU Munich) research about Dynamically Scalable Fog Architectures, Anne Hess’s (Fraunhofer IESE, Kaiserslautern) work on Crossing Disciplinary Borders to Improve Requirements Communication, Istvan Koren’s (RWTH Aachen U) thesis DevOpsUse: A Community-Oriented Methodology for Societal Software Engineering, Yannic Noller’s (NU Singapore) work on Hybrid Differential Software Testing, Dominic Steinhofel’s (TU Darmstadt) thesis entitled Ever Change a Running System: Structured Software Reengineering Using Automatically Proven-Correct Transformation Rules, Peter Wägemann’s (FAU Erlangen-Nürnberg) work Static Worst-Case Analyses and Their Validation Techniques for Safety-Critical Systems, Michael von Wenckstern’s (RWTH Aachen U) research on Improving the Model-Based Systems Engineering Process, and Franz Zieris’s (FU Berlin) thesis on Understanding How Pair Programming Actually Works in Industry: Mechanisms, Patterns, and Dynamics – which actually won the award. The chapters describe key findings of the respective works, show their relevance and applicability to practice and industrial software engineering projects, and provide additional information and findings that have only been discovered afterwards, e.g. when applying the results in industry. This way, the book is not only interesting to other researchers, but also to industrial software professionals who would like to learn about the application of state-of-the-art methods in their daily work.
    Keywords: Software Engineering ; Software Development ; Requirements Engineering ; Software Modeling ; Software Research ; Ernst Denert Award ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJQ Business mathematics and systems ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYZ Human–computer interaction::UYZM Information architecture
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    Serotonin and the CNS (2022)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Serotonin is an ancient neurotransmitter system involved in various systems and functions in the body and plays an important role in health and disease. The present volume illustrates the broadness of the involvement of serotonergic activity in many processes, focusing particularly on disorders of the brain, including depression, stress and fear, Alzheimer’s disease, aggression, sexual behavior, and neuro-immune disorders. Chapters illustrate techniques and methods used to study the complex role of the serotonergic system in all kinds of processes, present new hypotheses for several brain disorders like sleep and depression, and use mathematical modeling as a tool to advance knowledge of the extremely complex brain and body processes.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Genetic Polymorphisms (2022)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book provides a glimpse into the dynamic process of genetic polymorphism by presenting studies carried out on different kinds of organisms at the DNA level or gene expression level. Chapters address such topics as genetic polymorphism in animals, gametocyte biomarkers, thrombotic disorders, prostate cancer, and more.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Synthetic Genomics (2022)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Down Syndrome and Other Chromosome Abnormalities (2022)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book provides a concise yet comprehensive source of current information on Down syndrome and other chromosomal abnormalities. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. Key features of this book are as follows: • Mechanisms of aneuploidy. • Effect of sociodemographic factors on different congenital disorders. • Haematological malignancies and congenital heart disease in Down syndrome. • Prenatal screening, management and counselling to detect Down syndrome and other chromosomal abnormalities. While aimed primarily at research workers on Down syndrome and different types of chromosomal disorders, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially the parents and relatives of children suffering from Down syndrome and other chromosomal abnormality syndromes.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Brain-Computer Interface (2022)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Brain-computer interfacing (BCI) with the use of advanced artificial intelligence identification is a rapidly growing new technology that allows a silently commanding brain to manipulate devices ranging from smartphones to advanced articulated robotic arms when physical control is not possible. BCI can be viewed as a collaboration between the brain and a device via the direct passage of electrical signals from neurons to an external system. The book provides a comprehensive summary of conventional and novel methods for processing brain signals. The chapters cover a range of topics including noninvasive and invasive signal acquisition, signal processing methods, deep learning approaches, and implementation of BCI in experimental problems.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Gene Therapy (2021)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-03-31
    Description: The aim of this book is to cover key aspects of existing problems in the field of development and future perspectives in gene therapy. Contributions consist of basic and translational research, as well as clinical experiences, and they outline functional mechanisms, predictive approaches, patient-related studies and upcoming challenges in this stimulating but also controversial field of gene therapy research. This source will make our doctors become comfortable with the common problems of gene therapy and inspire others to delve a bit more deeply into a topic of interest.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Mutations in Human Genetic Disease (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Different types of mutation can vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture. The genomes of higher organisms are now known to contain "pervasive architectural flaws" in that certain DNA sequences are inherently mutation prone by virtue of their base composition, sequence repetitivity and/or epigenetic modification. In this volume, a number of different authors from diverse backgrounds describe how the nature, location and frequency of different types of mutation causing inherited disease are shaped in large part, and often in remarkably predictable ways, by the local DNA sequence environment.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Tools and Algorithms for the Construction and Analysis of Systems (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This open access two-volume set constitutes the proceedings of the 26th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2020, which took place in Dublin, Ireland, in April 2020, and was held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2020. The total of 60 regular papers presented in these volumes was carefully reviewed and selected from 155 submissions. The papers are organized in topical sections as follows: Part I: Program verification; SAT and SMT; Timed and Dynamical Systems; Verifying Concurrent Systems; Probabilistic Systems; Model Checking and Reachability; and Timed and Probabilistic Systems. Part II: Bisimulation; Verification and Efficiency; Logic and Proof; Tools and Case Studies; Games and Automata; and SV-COMP 2020.
    Keywords: Software Engineering/Programming and Operating Systems ; Special Purpose and Application-Based Systems ; Computer System Implementation ; Control Structures and Microprogramming ; Mathematics of Computing ; open access ; specification and verification techniques ; software and hardware verification ; SAT and SMT solving ; theorem proving ; model checking ; static and dynamic program analysis ; testing ; system construction and transformation techniques ; tool environments and tool architectures ; abstraction techniques for modeling and verification ; compositional and refinement-based methodologies ; mathematics ; software engineering ; software design ; architecting ; software architecture ; embedded systems ; automata theory ; linguistics ; Software Engineering ; Operating systems ; Expert systems / knowledge-based systems ; Systems analysis & design ; Algorithms & data structures ; Mathematical theory of computation ; Maths for computer scientists ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQE Expert systems / knowledge-based systems ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYD Systems analysis and design ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMB Algorithms and data structures ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYA Mathematical theory of computation
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    Flow Cytometry (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: "Flow Cytometry - Recent Perspectives" is a compendium of comprehensive reviews and original scientific papers. The contents illustrate the constantly evolving application of flow cytometry to a multitude of scientific fields and technologies as well as its broad use as demonstrated by the international composition of the contributing author group. The book focuses on the utilization of the technology in basic sciences and covers such diverse areas as marine and plant biology, microbiology, immunology, and biotechnology. It is hoped that it will give novices a valuable introduction to the field, but will also provide experienced flow cytometrists with novel insights and a better understanding of the subject.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Bipolar Disorder (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Bipolar Disorder: Portrait of a Complex Mood Disorder is a step towards integrating many diverse perspectives on BD. As we shall see, such diversity makes it difficult to clearly define the boundaries of BD. It is helpful to view BD from this perspective, as a final common pathway arises from multiple frames of reference. The integration of epigenetics, molecular pharmacology, and neurophysiology is essential. One solution involves using this diverse data to search for endophenotypes to aid researchers, even though most clinicians prefer broader groupings of symptoms and clinical variables. Our challenge is to consolidate this new information with existing clinical practice in a usable fashion. This need for convergent thinkers who can integrate the findings in this book remains a critical need. This book is a small step in that direction and hopefully guides researchers and clinicians towards a new synthesis of basic neurosciences and clinical psychiatry
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    When Things Go Wrong (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: In this book we have experts writing on various neuroscience topics ranging from mental illness, syndromes, compulsive disorders, brain cancer and advances in therapies and imaging techniques. Although diverse, the topics provide an overview of an array of diseases and their underlying causes, as well as advances in the treatment of these ailments. This book includes three chapters dedicated to neurodegenerative diseases, undoubtedly a group of diseases of huge socio-economic importance due to the number of people currently suffering from this type of disease but also the prediction of a huge increase in the number of people becoming afflicted. The book also includes a chapter on the molecular and cellular aspects of brain cancer, a disease which is still amongst the least treatable of cancers.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Autism Spectrum Disorders (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients†themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Advances in the Treatment of Ischemic Stroke (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: In recent years research on ischemic stroke has developed powerful therapeutic tools. The novel frontiers of stem cells therapy and of hypothermia have been explored, and novel brain repair mechanisms have been discovered. Limits to intravenous thrombolysis have been advanced and powerful endovascular tools have been put at the clinicians' disposal. Surgical decompression in malignant stroke has significantly improved the prognosis of this often fatal condition. This book includes contributions from scientists active in this innovative research. Stroke physicians, students, nurses and technicians will hopefully use it as a tool of continuing medical education to update their knowledge in this rapidly changing field.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Neurodegenerative Diseases (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Chromosomal Abnormalities (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Chromosomes are vital components of genetic material, and, as such, distruption or changes to the structure of chromosomes can result in different health problems and deficits. This book explains chromosomal abnomalities and their effects on living organisms, including humans and plants. Classical and molecular cytogenetics techniques have a considerable number of potential applications, especially in clinical trials and biomedical diagnosis, making them a strong and insightful complement to other molecular and genomic approaches. Chapters cover topics including Down syndrome, fetal ultrasounds, acute myeloid leukemia, and Phelan-McDermid syndrome, among others.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Point Mutation (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Reversible Computation: Extending Horizons of Computing (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This open access State-of-the-Art Survey presents the main recent scientific outcomes in the area of reversible computation, focusing on those that have emerged during COST Action IC1405 "Reversible Computation - Extending Horizons of Computing", a European research network that operated from May 2015 to April 2019. Reversible computation is a new paradigm that extends the traditional forwards-only mode of computation with the ability to execute in reverse, so that computation can run backwards as easily and naturally as forwards. It aims to deliver novel computing devices and software, and to enhance existing systems by equipping them with reversibility. There are many potential applications of reversible computation, including languages and software tools for reliable and recovery-oriented distributed systems and revolutionary reversible logic gates and circuits, but they can only be realized and have lasting effect if conceptual and firm theoretical foundations are established first.
    Keywords: Logic Design ; Computer System Implementation ; Computer Communication Networks ; Special Purpose and Application-Based Systems ; Software Engineering ; Operating Systems ; open access ; reversible computation ; semantics of reversible computation ; formal methods ; models of computation ; circuit design ; simulation ; robotics ; debugging ; quantum computing ; wireless communications ; programming languages ; dependability ; modelling of biochemical systems ; computer networks ; engineering ; software engineering ; parallel processing systems ; theoretical computer science ; Computer architecture & logic design ; Systems analysis & design ; Network hardware ; Expert systems / knowledge-based systems ; Operating systems ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYF Computer architecture and logic design ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYD Systems analysis and design ; thema EDItEUR::U Computing and Information Technology::UK Computer hardware::UKN Network hardware ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQE Expert systems / knowledge-based systems ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::U Computing and Information Technology::UL Operating systems
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    Reviews on Selected Topics of Telomere Biology (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Telomeres, located at the ends of linear chromosomes, are essential for genome stability and integrity. Advances in telomere researches have linked telomere dysfunction with cellular aging and a number of age-related human diseases. Recent studies further expanded our knowledge of telomere functions - telomeres are shown to be important for microbial pathogen virulence and telomere proteins have important non-telomeric cellular functions. This book includes current opinions on selected aspects of telomere research and their implication, in hope to help us focus better on future studies and enhance our research progress.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Molecular Mechanisms of the Aging Process and Rejuvenation (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Viral Gene Therapy (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The development of technologies that allow targeting of specific cells has progressed substantially in recent years for several types of vectors, particularly viral vectors, which have been used in 70% of gene therapy clinical trials. Particular viruses have been selected as gene delivery vehicles because of their capacities to carry foreign genes and their ability to efficiently deliver these genes associated with efficient gene expression. This book is designed to present the most recent advances in viral gene therapy
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Software Product Line (2021)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-04-14
    Description: The Software Product Line (SPL) is an emerging methodology for developing software products. Currently, there are two hot issues in the SPL: modelling and the analysis of the SPL. Variability modelling techniques have been developed to assist engineers in dealing with the complications of variability management. The principal goal of modelling variability techniques is to configure a successful software product by managing variability in domain-engineering. In other words, a good method for modelling variability is a prerequisite for a successful SPL. On the other hand, analysis of the SPL aids the extraction of useful information from the SPL and provides a control and planning strategy mechanism for engineers or experts. In addition, the analysis of the SPL provides a clear view for users. Moreover, it ensures the accuracy of the SPL. This book presents new techniques for modelling and new methods for SPL analysis.
    Keywords: Software Engineering ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering
    Language: English
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    Antisense Therapy (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer. Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book summarizes and presents the best updates, therapeutic principles, methods, and applications in the field and offers meaningful information to move treatment discovery forward.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Model-Based Engineering of Collaborative Embedded Systems (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This Open Access book presents the results of the "Collaborative Embedded Systems" (CrESt) project, aimed at adapting and complementing the methodology underlying modeling techniques developed to cope with the challenges of the dynamic structures of collaborative embedded systems (CESs) based on the SPES development methodology. In order to manage the high complexity of the individual systems and the dynamically formed interaction structures at runtime, advanced and powerful development methods are required that extend the current state of the art in the development of embedded systems and cyber-physical systems. The methodological contributions of the project support the effective and efficient development of CESs in dynamic and uncertain contexts, with special emphasis on the reliability and variability of individual systems and the creation of networks of such systems at runtime. The project was funded by the German Federal Ministry of Education and Research (BMBF), and the case studies are therefore selected from areas that are highly relevant for Germany’s economy (automotive, industrial production, power generation, and robotics). It also supports the digitalization of complex and transformable industrial plants in the context of the German government's "Industry 4.0" initiative, and the project results provide a solid foundation for implementing the German government's high-tech strategy "Innovations for Germany" in the coming years.
    Keywords: Software Engineering ; Software Management ; Automotive Engineering ; Special Purpose and Application-Based Systems ; IT in Business ; Model-Driven Software Development ; Requirements Engineering ; Automotive Software Engineering ; Embedded Systems ; Open Access ; SPES Methodology ; Simulation ; Co-Design of Systems ; Business mathematics & systems ; Business applications ; Automotive technology & trades ; Automotive (motor mechanic) skills ; Expert systems / knowledge-based systems ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJQ Business mathematics and systems ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TR Transport technology and trades::TRC Automotive technology and trades ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQE Expert systems / knowledge-based systems
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    Genotoxicity and Mutagenicity (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This edited book, “Genotoxicity and Mutagenicity - Mechanisms and Test Methods”, aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Programming Languages and Systems (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This open access book constitutes the proceedings of the 30th European Symposium on Programming, ESOP 2021, which was held during March 27 until April 1, 2021, as part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2021. The conference was planned to take place in Luxembourg and changed to an online format due to the COVID-19 pandemic. The 24 papers included in this volume were carefully reviewed and selected from 79 submissions. They deal with fundamental issues in the specification, design, analysis, and implementation of programming languages and systems.
    Keywords: Programming Languages, Compilers, Interpreters ; Natural Language Processing (NLP) ; Software Engineering ; Logics and Meanings of Programs ; Computer Systems Organization and Communication Networks ; Compilers and Interpreters ; Computer Science Logic and Foundations of Programming ; Computer Engineering and Networks ; computer programming ; concurrency theory ; distributed computer systems ; formal logic ; lamdba calculi ; linguistics ; logic ; object-oriented programming ; parallel processing systems ; probabilistic programming ; process calculi ; program compilers ; semantics ; software design ; software quality ; theory ; types ; verification and validation ; Programming & scripting languages: general ; Compilers & interpreters ; Natural language & machine translation ; Computer programming / software engineering ; Computer architecture & logic design ; Computer networking & communications ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMX Programming and scripting languages: general ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications
    Language: English
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    Recent Advances in Autism Spectrum Disorders (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The pace of research on Autism Spectrum Disorders (ASD) can only be described as extraordinary as this volume shows. It is extremely difficult for any single professional to keep abreast of all the developments in this area. This volume gathers together leading researchers and expert clinicians from many different parts of the world to produce this "up-to-the-minute" volume. It gives an in depth view of many areas of research which may be unfamiliar to the clinician and indeed researcher focused on their own area of interest. The volume gives an in depth overview of the field of Autism Spectrum Disorders.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Next Generation Sequencing (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Synucleins (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There are three main types of synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Synucleins are small, naturally unfolded proteins prone to aggregate and form intracellular inclusions, which impair normal cellular functions. This book presents new data on synuclein aggregation and its effect on cholesterol transport. It also discusses the role of genetic contribution to these diseases and approaches to inhibition of synuclein aggregation.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Fundamental Aspects of DNA Replication (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed. We hope that readers will find this book interesting, helpful and inspiring.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    DNA Methylation (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Epigenetics is one of the most exciting and rapidly developing areas of modern genetics with applications in many disciplines from medicine to agriculture. The most common form of epigenetic modification is DNA methylation, which plays a key role in fundamental developmental processes such as embryogenesis and also in the response of organisms to a wide range of environmental stimuli. Indeed, epigenetics is increasing regarded as one of the major mechanisms used by animals and plants to modulate their genome and its expression to adapt to a wide range of environmental factors. This book brings together a group of experts at the cutting edge of research into DNA methylation and highlights recent advances in methodology and knowledge of underlying mechanisms of this most important of genetic processes. The reader will gain an understanding of the impact, significance and recent advances within the field of epigenetics with a focus on DNA methylation.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Gene Therapy (2021)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-03-31
    Description: Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Tools and Algorithms for the Construction and Analysis of Systems (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This open access two-volume set constitutes the proceedings of the 27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2021, which was held during March 27 – April 1, 2021, as part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2021. The conference was planned to take place in Luxembourg and changed to an online format due to the COVID-19 pandemic. The total of 41 full papers presented in the proceedings was carefully reviewed and selected from 141 submissions. The volume also contains 7 tool papers; 6 Tool Demo papers, 9 SV-Comp Competition Papers. The papers are organized in topical sections as follows: Part I: Game Theory; SMT Verification; Probabilities; Timed Systems; Neural Networks; Analysis of Network Communication. Part II: Verification Techniques (not SMT); Case Studies; Proof Generation/Validation; Tool Papers; Tool Demo Papers; SV-Comp Tool Competition Papers.
    Keywords: Theory of Computation ; Computer Systems Organization and Communication Networks ; Control Structures and Microprogramming ; Software Engineering ; Computer Engineering and Networks ; architecture verification and validation ; automata theory ; computer systems ; distributed computer systems ; embedded systems ; formal logic ; mathematics ; model checking ; model-checking ; parallel processing systems ; SAT and SMT solving ; software architecture ; static and dynamic program analysis ; theorem-proving ; verification and validation ; Computer science ; Mathematical theory of computation ; Computer networking & communications ; Algorithms & data structures ; thema EDItEUR::U Computing and Information Technology::UY Computer science ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering
    Language: English
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    Osteogenesis (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book provides an in-depth overview of current knowledge about Osteogenesis, including molecular mechanisms, transcriptional regulators, scaffolds, cell biology, mechanical stimuli, vascularization and osteogenesis related diseases. Hopefully, the publication of this book will help researchers in this field to decide where to focus their future efforts, and provide an overview for surgeons and clinicians who wish to be directed in the developments related to this fascinating subject.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Gene Therapy (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The Gene Therapy field is living exciting times after more than 20 years of poor results. Scientist and clinicians working in the gene therapy field have encountered many problems in the past that are now starting to be solved. The development of safer and more efficient gene transfer vectors and the advances on the cell therapy field have open new opportunities to tackle different diseases. The aim of this book is to bring together information about the different gene therapy tools, the clinical successes of gene therapy and the future applications.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Apoptosis and Medicine (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book looks at the latest research studies on apoptosis in medicine. It is divided into three sections for convenient and easy reading. The first section which comprises two chapters is an introduction of the subject of apoptosis to the uninitiated. The second section which comprises a single solitary chapter looks at apoptosis in normal physiology during bone resorption under mechanical stress. The third and the final section reviews apoptosis in a number of pathological conditions with an emphasis on cancer.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Molecular Cloning (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The development of molecular cloning technology in the early 1970s created a revolution in the biological and biomedical sciences that extends to this day. The contributions in this book provide the reader with a perspective on how pervasive the applications of molecular cloning have become. The contributions are organized in sections based on application, and range from cancer biology and immunology to plant and evolutionary biology. The chapters also cover a wide range of technical approaches, such as positional cloning and cutting edge tools for recombinant protein expression. This book should appeal to many researchers, who should find its information useful for advancing their fields.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Health Problems in Down Syndrome (2021)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-03-31
    Description: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on diseases associated with Down syndrome. Inside, you will find state-of-the-art information on diseases associated with Down syndrome; improvement of cognitive skills in Down syndrome; and research approaches on Down syndrome. Although aimed primarily at research workers on Down syndrome, we hope that the appeal of this book extends beyond the narrow confines of academic interest and reaches a wider audience, especially parents, relatives, and health care providers who work with infants and children with Down syndrome.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Neuroimaging (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: In vivo brain neuroimaging with cutting-edge technologies has achieved great success with high spatial and temporal resolutions. Several distinct medical imaging perspectives such as disease neurobiology, multimodal imaging techniques and applications, large-size clinical trials of neuro-oncology, and bioinformatics with illustrative examples and comprehensive summaries could expand our knowledge of neuroimaging mechanism, methodologies, and applications. This book highlights the possibility and achievement of early detection and multiple neuroimaging biomarkers based on various features for pathophysiological probing and therapeutic prevention. It examines the use of neuroimaging techniques such as magnetic resonance imaging (MRI), electroencephalography (EEG), and near-infrared resonance spectroscopy (NIRS) with specific and innovative biomedical applications. It provides thorough reviews, accurate descriptions, and confirmative evidences of many related important research topics together with up-to-date imaging network management.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Feed Your Mind (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Nutrition is an environmental factor modulating physiology throughout life and especially brain function. Nutrients in the brain can either fuel brain cells, contribute to tissue architecture, or initiate signaling pathways through their derivatives. Nutrients ultimately participate in brain development, cognitive and emotional behaviors, and can influence the susceptibility to develop brain pathologies. This book is a selection of current research on the impact of diet on brain function. Chapters include the role of lipids and glucose on the brain, nutrition and autophagy, and consequences of enteral feeding on brain-gut interactions. Taken together, this book targets all scientists, clinicians, teachers, and students eager to learn more about the impact of nutrition on brain function.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    DNA Replication and Related Cellular Processes (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Since the discovery of the DNA structure researchers have been highly interested in the molecular basis of genome inheritance. This book covers a wide range of aspects and issues related to the field of DNA replication. The association between genome replication, repair and recombination is also addressed, as well as summaries of recent work of the replication cycles of prokaryotic and eukaryotic viruses. The reader will gain an overview of our current understanding of DNA replication and related cellular processes, and useful resources for further reading.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Good Research Practice in Non-Clinical Pharmacology and Biomedicine (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-01
    Description: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
    Keywords: Pharmacology/Toxicology ; Neurosciences ; Cardiology ; Oncology ; Pharmacology ; Neuroscience ; Internal Medicine ; reproducibility ; study design ; data analysis ; data reporting ; data integrity ; quality management ; open access ; Cardiovascular medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
    Language: English
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    Genetics and Etiology of Down Syndrome (2021)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-03-31
    Description: This book provides a concise yet comprehensive source of current information on Down syndrome. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. This book has been divided into four sections, beginning with the Genetics and Etiology and ending with Prenatal Diagnosis and Screening. Inside, you will find state-of-the-art information on: 1. Genetics and Etiology 2. Down syndrome Model 3. Neurologic, Urologic, Dental & Allergic disorders 4. Prenatal Diagnosis and Screening Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents and relatives of Down syndrome patients.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Targets in Gene Therapy (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Building Better Interfaces for Remote Autonomous Systems (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This 'Open Access' SpringerBrief provides foundational knowledge for designing autonomous, asynchronous systems and explains aspects of users relevant to designing for these systems, introduces principles for user-centered design, and prepares readers for more advanced and specific readings. It provides context and the implications for design choices made during the design and development of the complex systems that are part of operation centers. As such, each chapter includes principles to summarize the design implication that engineers can use to inform their own design of interfaces for operation centers and similar systems. It includes example materials for the design of a fictitious system, which are referenced in the book and can be duplicated and extended for real systems. The design materials include a system overview, the system architecture, an example scenario, a stakeholder analysis, a task analysis, a description of the system and interface technology, and contextualized design guidelines. The guidelines can be specified because the user, the task, and the technology are well specified as an example. Building Better Interfaces for Remote Autonomous Systems is for working system engineers who are designing interfaces used in high throughput, high stake, operation centers (op centers) or control rooms, such as network operation centers (NOCs). Intended users will have a technical undergraduate degree (e.g., computer science) with little or no training in design, human sciences, or with human-centered iterative design methods and practices. Background research for the book was supplemented by interaction with the intended audience through a related project with L3Harris Technologies (formerly Harris Corporation).
    Keywords: User Interfaces and Human Computer Interaction ; Software Engineering ; Autonomous Systems ; User-Centered Design ; Operation Centres ; Interface Technology ; Human-Centered Design ; Open Access ; User interface design & usability ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYZ Human–computer interaction::UYZG User interface design and usability ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering
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    Gene Editing (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Paresthesia (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Paresthesias are spontaneous or evoked abnormal sensations of tingling, burning, pricking, or numbness of a person's skin with no apparent long-term physical effect. Patients generally describe a lancinating or burning pain, often associated with allodynia and hyperalgesia. The manifestation of paresthesia can be transient or chronic. Transient paresthesia can be a symptom of hyperventilation syndrome or a panic attack, and chronic paresthesia can be a result of poor circulation, nerve irritation, neuropathy, or many other conditions and causes. This book is written by authors that are respected in their countries as well as worldwide. Each chapter is written so that everyone can understand, treat and improve the lives of each patient.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Visual Cortex (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The neurosciences have experienced tremendous and wonderful progress in many areas, and the spectrum encompassing the neurosciences is expansive. Suffice it to mention a few classical fields: electrophysiology, genetics, physics, computer sciences, and more recently, social and marketing neurosciences. Of course, this large growth resulted in the production of many books. Perhaps the visual system and the visual cortex were in the vanguard because most animals do not produce their own light and offer thus the invaluable advantage of allowing investigators to conduct experiments in full control of the stimulus. In addition, the fascinating evolution of scientific techniques, the immense productivity of recent research, and the ensuing literature make it virtually impossible to publish in a single volume all worthwhile work accomplished throughout the scientific world. The days when a single individual, as Diderot, could undertake the production of an encyclopedia are gone forever. Indeed most approaches to studying the nervous system are valid and neuroscientists produce an almost astronomical number of interesting data accompanied by extremely worthy hypotheses which in turn generate new ventures in search of brain functions. Yet, it is fully justified to make an encore and to publish a book dedicated to visual cortex and beyond. Many reasons validate a book assembling chapters written by active researchers. Each has the opportunity to bind together data and explore original ideas whose fate will not fall into the hands of uncompromising reviewers of traditional journals. This book focuses on the cerebral cortex with a large emphasis on vision. Yet it offers the reader diverse approaches employed to investigate the brain, for instance, computer simulation, cellular responses, or rivalry between various targets and goal directed actions. This volume thus covers a large spectrum of research even though it is impossible to include all topics in the extremely diverse field of neurosciences.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Clinical Flow Cytometry (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: "Clinical Flow Cytometry - Emerging Applications" contains a collection of reviews and original papers that illustrate the relevance of flow cytometry for the study of specific diseases and clinical evaluations. The chapters have been contributed by authors from a wide variety of countries showing the broad application and importance of this technology in medicine. Examples include chapters on autoimmune disease, cancer, and the evaluation of new drugs. The book is intended to give newcomers a helpful introduction, but also to provide experienced flow cytometrists with novel insights and a better understanding of clinical cytometry.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Advances in the Study of Genetic Disorders (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The studies on genetic disorders have been rapidly advancing in recent years as to be able to understand the reasons why genetic disorders are caused. The first Section of this volume provides readers with background and several methodologies for understanding genetic disorders. Genetic defects, diagnoses and treatments of the respective unifactorial and multifactorial genetic disorders are reviewed in the second and third Sections. Certainly, it is quite difficult or almost impossible to cure a genetic disorder fundamentally at the present time. However, our knowledge of genetic functions has rapidly accumulated since the double-stranded structure of DNA was discovered by Watson and Crick in 1956. Therefore, nowadays it is possible to understand the reasons why genetic disorders are caused. It is probable that the knowledge of genetic disorders described in this book will lead to the discovery of an epoch of new medical treatment and relieve human beings from the genetic disorders of the future.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    The Pangenome (2021)
    Springer Nature | Springer
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    Publication Date: 2024-04-05
    Description: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
    Keywords: Microbial Genetics and Genomics ; Evolutionary Biology ; Genetics and Population Dynamics ; Microbial Ecology ; Human Genetics ; Genetics and Genomics ; Comparative genomics ; Metagenomics ; Microbial Population Analysis ; Pangenome Profile ; Supra-Genome Analysis ; Adaptive Evolution ; Computational Tools ; Bioinformatic Genomics ; Core Dispensable Genome ; Selection, Recombination, Composition ; Acquired Resistance ; Bacterial Species Concept ; Genomic Diversity ; Bacterial Ecology, Microevolution ; Open Access ; Pan-metagenomics ; Pan-microbiomics ; Pan-epigenome ; Gene Transfer ; Pan-phenomes ; Microbiology (non-medical) ; Genetics (non-medical) ; Evolution ; Applied mathematics ; Ecological science, the Biosphere ; Medical genetics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAJ Evolution ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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    Protein Phosphorylation in Human Health (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: 15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Post Traumatic Stress Disorders in a Global Context (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: If, as a health care or social service provider, one was called upon to help someone who has experienced terror in the hands of a hostage taker, an irate and chronically abusive spouse or parent, or a has survived a motor vehicle accident, landslide, earthquake, hurricane or even a massive flood, what would be one's priority response? What would be considered as the most pressing need of the individual requiring care? Whatever the answer to each of these questions, people who have experienced terror, suffer considerable psychological injury. Post-Traumatic Stress Disorder in a Global Context offers some answers to meet the needs of health care and socials service providers in all settings, whether in a hospital emergency room, at the war front, or natural disaster site. The take home message is, after providing emergency care, there is always a pressing need to provide mental health care to all victims of traumatic stress.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Chromatin Remodelling (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The term "chromatin remodelling" is widely used to describe changes in chromatin structure which is controlled by histone-modifying enzymes, chromatin remodelling complexes, non-histone DNA-binding proteins and noncoding RNAs. Many human diseases such as cancer, various genetic syndromes, autism and infectious disease have been linked to the disruption of these control processes by genetic, environmental or microbial factors. Therefore, to unravel the mechanisms by which they operate is one of the most exciting and rapid developing fields of modern biology and will contribute to new ways in treatment of these diseases. The chapters in this book will focus on recent advances in our understanding of the mechanisms that govern the dynamic structural of chromatin, thereby providing important insights into gene regulation, DNA repair, and human diseases.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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    Foundations of Multi-Paradigm Modelling for Cyber-Physical Systems (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-04-14
    Description: This open access book coherently gathers well-founded information on the fundamentals of and formalisms for modelling cyber-physical systems (CPS). Highlighting the cross-disciplinary nature of CPS modelling, it also serves as a bridge for anyone entering CPS from related areas of computer science or engineering. Truly complex, engineered systems—known as cyber-physical systems—that integrate physical, software, and network aspects are now on the rise. However, there is no unifying theory nor systematic design methods, techniques or tools for these systems. Individual (mechanical, electrical, network or software) engineering disciplines only offer partial solutions. A technique known as Multi-Paradigm Modelling has recently emerged suggesting to model every part and aspect of a system explicitly, at the most appropriate level(s) of abstraction, using the most appropriate modelling formalism(s), and then weaving the results together to form a representation of the system. If properly applied, it enables, among other global aspects, performance analysis, exhaustive simulation, and verification. This book is the first systematic attempt to bring together these formalisms for anyone starting in the field of CPS who seeks solid modelling foundations and a comprehensive introduction to the distinct existing techniques that are multi-paradigmatic. Though chiefly intended for master and post-graduate level students in computer science and engineering, it can also be used as a reference text for practitioners.
    Keywords: Software Engineering ; Cyber-physical systems, IoT ; Special Purpose and Application-Based Systems ; Computer Applications ; Computer-Aided Engineering (CAD, CAE) and Design ; Open Access ; Embedded and cyber-physical systems ; Software design engineering ; Model-driven software engineering ; Modelica ; Performance Analysis ; Design Languages ; System Description Languages ; System and Modeling ; DEVS ; Statecharts ; Petri Nets ; Multi-Paradigm Modeling ; AADL ; Concurrency Modeling ; Electrical engineering ; Cybernetics & systems theory ; Expert systems / knowledge-based systems ; Information technology: general issues ; Computer-aided design (CAD) ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THR Electrical engineering ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQE Expert systems / knowledge-based systems ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::U Computing and Information Technology::UG Graphical and digital media applications::UGC Computer-aided design (CAD)
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    Basal Ganglia (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The function of the Basal Ganglia is a subject of increasing prominence, not only among neuroanatomists, neurobiologists, cognitive-scientists and psychiatrists, but also among clinical ergonomists, rehabilitation, internal medicine and public health medics. This volume is the first of its kind. Scientists of diverse backgrounds join to explore issues about the Basal Ganglia from multiple angles. Basal Ganglia - An Integrative View explores the Basal Ganglia from diverse perspectives, sometimes as starting point others as end of diverse pathologies. It reaches from basic neuroanatomical explanations to higher-order integrative processes. It will be essential reading for both frontier neuroscientists and public health actors interested in the nature of Basal Ganglia and will offer a valuable example for the integration of leading research.
    Keywords: Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    RNA Processing (2021)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: RNA functions broadly as informational molecule, genome, enzyme and machinery for RNA processing. While these functions reflect ancient activities, they also remain vital components of contemporary biochemical pathways. In eukaryotic cells RNA processing impacts the biogenesis of RNA molecules of essentially every shape and function. The collection of articles in this volume describes the current state of understanding of the broad array of RNA processing events in animal and plant cells, key unanswered questions, and cutting edge approaches available to address these questions. Some questions discussed in this volume include, how viruses subvert the RNA processing machinery of the host cell, how the coordination of co-transcriptional RNA processing is regulated at the level of chromatin, the status of RNA processing in plant organelles, and how micro RNA machinery is biosynthesized and regulated.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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