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  • Books  (319)
  • inflammation  (319)
  • MDPI - Multidisciplinary Digital Publishing Institute  (298)
  • IntechOpen  (21)
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  • Books  (319)
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  • 1
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    Potential Anti-SARS-CoV-2 Molecular Strategies (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: Herein we describe some molecular aspects of the recent anti-COVID-19 research, including some approaches making use of natural remedies, especially from medicinal plants, in silico methods, and different experimental procedures that led to the discovery of novel targets of SARS-CoV-2 and consequently novel potential COVID-19 therapeutics. COVID-19 vaccines also find mention in this book with also a description of some adverse effects reported in some cases. Considering that the different beta coronaviruses present certain conserved biomolecular mechanisms and, thus, some common therapeutic targets, finding effective therapies for a specific member of their family (such as SARS-CoV, SARS-CoV-2, and MERS-CoV) even in a scenario of a reduced impact at the time of the related disease on humankind is still relevant as it could offer or inspire efficacious therapeutic strategies not only in the context of novel pathogenic mutations of the already known beta coronaviruses, but also when future zoonoses caused by other beta coronaviruses will emergence, which is not unlikely to occur in the current world where the interactions between humans and wildlife are made more and more frequent due to the growing loss of intact ecosystems worldwide.
    Keywords: coronavirus infections ; pandemics ; natural compounds ; clove ; Syzygium aromaticum ; eugenol ; eugeniin ; SARS-CoV-2 ; COVID-19 ; phytochemicals ; herbal medicine ; catechin ; polyphenol ; tea leaf extract ; theaflavin ; virucidal activity ; MERS-CoV ; S1-NTD ; pharmacophore modeling ; ADME ; quantum mechanical calculation ; DFT ; FMO ; MM/GBSA ; molecular docking ; Molecular Dynamics Simulation ; HOMO ; LUMO ; COVID-19 vaccine ; disseminated intravascular coagulation ; heparin induced thrombocytopenia ; platelet factor 4 ; thrombosis ; thrombotic thrombo-cytopenic purpura ; vaccine induced thrombocytopenia and thrombosis ; disinfectants ; ethanol ; hand hygiene ; ozonated water ; slightly acidic electrolyzed water ; virucidal mechanism ; coronavirus ; renal disease ; nephrotoxicity ; reno-protective effect ; green tea ; epigallocatechin-3-gallate (EGCG) ; flavonoids ; natural products ; medicinal plant ; SARS-Cov-2 nsp10 ; structural similarity ; fingerprint ; ADMET ; toxicity ; main protease ; triazole ; docking ; MD simulation ; drug ; proteomic ; vaccine ; immunology ; biomarker ; cheminformatics ; phytocompounds ; systems pharmacology ; anti-COVID-19 ; drug repositioning ; molecular dynamic simulations ; binding free energy ; signal peptide ; RBD protein ; secretion ; mutant ; nucleocapsid or nucleoprotein ; structure-based drug discovery ; alphafold model and molecular dynamics ; neuroinflammation ; brain fog ; neuropeptides ; neurotransmission ; metabolism ; NSAIDs ; inflammation ; ketoprofen ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Language: English
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  • 2
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    Integrated Role of Nutrition and Physical Activity for Lifelong Health (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: As computer and space technologies have been developed, geoscience information systems (GIS) and remote sensing (RS) technologies, which deal with the geospatial information, have been rapidly maturing. Moreover, over the last few decades, machine learning techniques including artificial neural network (ANN), deep learning, decision tree, and support vector machine (SVM) have been successfully applied to geospatial science and engineering research fields. The machine learning techniques have been widely applied to GIS and RS research fields and have recently produced valuable results in the areas of geoscience, environment, natural hazards, and natural resources. This book is a collection representing novel contributions detailing machine learning techniques as applied to geoscience information systems and remote sensing.
    Keywords: TA1-2040 ; T1-995 ; n/a ; sport games ; compensatory eating ; breath test ; exercise-induced anorexia ; Fitbit ; nutrition education ; senescence ; body weight ; sport nutrition ; fitness ; long-term follow-up ; self-efficacy ; protein ; food consumption ; cytokines ; physical exercise ; cardiometabolic health ; mediation analyses ; obesity ; food choice ; telomere length ; sporting events ; carbohydrates ; free radicals ; marathon ; adolescents ; movement skills ; naturally enriched 13C-milk proteins ; behavioral intervention ; acute exercise ; skeletal muscle damage ; Protein ; TERRA ; nutrition ; telemonitoring ; Latino ; adolescent ; macronutrients ; metabolism ; mechanisms of impact ; anabolic competence ; endurance exercise ; food healthiness ; exercise ; health promotion ; behavioral economics ; immunity ; stunting ; lifestyle intervention ; running ; telomerase ; dietary intake ; inflammation ; vegetarian ; recreational athlete ; physical performance ; out-of-home eating ; diet ; overweight ; dietary restriction ; soccer ; dual burden of malnutrition ; protein shake ; childhood memories ; chronic diseases ; music events ; oxidation ; added sugar ; lifestyle change ; vegan ; nudges ; food ; physical activity ; half-marathon ; health conscious ; free or reduced lunch ; low-income ; diet quality ; National School Lunch Program ; older adults ; aging ; sport spectators ; chronic low-grade systemic inflammation ; sport ; food intake ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 3
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    Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host–immune reactions near tumor environments.
    Keywords: endothelial cells ; oxidative stress ; inflammageing ; endothelial dysfunction ; aldehyde dehydrogenase-2 ; cardiovascular disease ; neurovascular disease ; vascular inflammation ; APE1/Ref-1 ; cardiovascular diseases ; subcellular localization ; serological biomarkers ; atherosclerosis ; aerobic exercise ; PCSK9 ; LOX-1 ; insulin resistance ; macrophage polarity ; serum γ-glutamyltransferase ; essential hypertension ; cardiovascular risk factors ; angiogenesis ; nargenicin A1 ; compound 9 ; VEGF ; VEGFR2 ; HIF-1α ; electronegative low-density lipoprotein ; LDL(–) ; L5 LDL ; oxidized LDL ; oxLDL ; ADMA ; arginine ; arginine paradox ; BH4 ; blood pressure ; COVID-19 ; dietary supplements ; endothelium ; eNOS uncoupling ; heart failure ; hypertension ; L-arginine ; myocardial infarction ; NADPH ; nitric oxide ; peripheral artery disease ; ApoE knockout mouse ; atorvastatin ; VCAM-1 ; galectin-3 ; neutrophil/lymphocyte ratio ; electronegative LDL ; LDL(−) ; lectin-like oxLDL receptor-1 ; dyslipidemia ; chronic venous insufficiency ; prolyl oligopeptidase (POP) ; inflammation ; endothelial disfunction ; lung disease ; endothelial to mesenchymal transition ; pulmonary hypertension ; pulmonary fibrosis ; metformin ; diabetes ; CV risk ; hyperglycemia ; glycated lipoproteins ; glycated LDL ; glycated HDL ; endothelial cell dysfunction ; molecular mechanisms ; epigenetic factors ; therapeutic approaches ; vasoactive factors ; EndoMT ; TGF-β ; epigenetics ; endothelial cell ; glycolysis ; metabolism ; pathological angiogenesis ; tumor microenvironment ; MRI (magnetic resonance imaging) ; high-fat diets ; plaque burden ; low-level laser therapy ; phototherapy ; vascular disease ; healing ; ischemia ; vascular calcification ; chronic kidney disease ; CKD ; uremic toxins ; hyperphosphatemia ; vascular smooth muscle cells ; VSMCs ; macrophages ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Language: English
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  • 4
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    Intervertebral Disc Regeneration (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.
    Keywords: hyaluronic acid ; disc repair ; annulus fibrosus repair ; biomaterials ; inflammatory biomarkers and signalling pathways ; nasal chondrocytes ; disc degeneration ; inflammation ; microenvironment ; nucleus pulposus ; cell ; spine ; intervertebral disc ; renin–angiotensin system ; degeneration ; regeneration ; intervertebral disc (IVD) ; stem cell ; scaffolds ; tissue engineering ; test method ; dynamic testing ; in vitro ; (lumbar) disc herniation ; physiological activities ; regenerative approaches ; nucleus pulposus progenitor cells ; cryopreservation ; Tie2 ; spheroid colony ; EZSPHERE ; CryoStor 10 ; growth factors ; differentiation ; mesenchymal stromal cell ; growth factor ; Wnt ; differentiation factor ; chondrogenesis ; cell therapy ; progenitor cells ; biomechanics ; lumbar disc herniation ; GDF5 ; GDF6 ; TGFβ ; nucleus pulposus progenitor cells (NPPC) ; losartanon ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 5
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    Bioassays and Biosensors for Rapid Detection and Analysis (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: The fast development of biosensors with high sensitivity through new functional materials introduced, or simplified the procedure in measurements, which is definitely important. However, more attentions should be paid for real applications, increasing tolerances against various matrix that potentially influence the performance of biosensors. This reprint focuses on the biosensors which were widely used in various fields after some problems were circumstanced, analytical methods development for containments in environments and foods, and biomarkers/hazardous substances in cells based on nanozyme or other nanoparticles, combined with antibodies, nucleic acids, aptamers or nanobodies, including enough sensitivity and satisfactory accuracy, maintaining enzyme activity at varied harsh environments.
    Keywords: autoinducer ; co-cultivation bioassay ; food safety ; foodborne pathogens ; N-acyl homoserine lactones ; plasmid-based biosensor ; Yersinia enterocolitica ; immunoassay ; antibody ; dibutyl phthalate ; scopoletin ; amplex red ; silver nanoparticles ; extracellular vesicles ; Fe3O4@TiO2 ; PD-L1 ; aptasensor ; chemiluminescence ; lung cancer ; non-invasive diagnosis ; bound-free phase ; micro/nanoparticles ; point-of-care ; centrifugal microfluidics ; inflammation ; reagent storage ; DNA ; biosensor ; electrochemiluminescence ; sensitivity ; amplification strategy ; COVID-19 ; SARS-CoV-2 ; spike glycoprotein ; peptide ; all-dielectric metasurface ; fluorescence sensor ; sandwich assay ; rapid antigen test ; omicron variant ; deoxynivalenol ; gold nanoparticles ; PAMAM ; multi-enzyme probes ; aptamer ; MnO2 ; sulfadiazine ; ALI/ARDS ; biosensors ; PR3 ; human NE ; MMP-2 ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
    Language: English
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  • 6
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    Virus-Based Nanomaterials and Nanostructures (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: A virus is considered a nanoscale organic material that can infect and replicate only inside the living cells of other organisms, ranging from animals and plants to microorganisms, including bacteria and archaea. The structure of viruses consists of two main parts: the genetic material from either DNA or RNA that carries genetic information, and a protein coat, called the capsid, which surrounds and protects the genetic material. By inserting the gene encoding functional proteins into the viral genome, the functional proteins can be genetically displayed on the protein coat to form bioengineered viruses. Therefore, viruses can be considered biological nanoparticles with genetically tunable surface chemistry and can serve as models for developing virus-like nanoparticles and even nanostructures. Via this process of viral display, bioengineered viruses can be mass-produced with lower cost and potentially used for energy and biomedical applications. This book highlights the recent developments and future directions of virus-based nanomaterials and nanostructures. The virus-based biomimetic materials formulated using innovative ideas were characterized for the applications of biosensors and nanocarriers. The research contributions and trends on virus-based materials covering energy harvesting devices to tissue regeneration in the last two decades are discussed.
    Keywords: virus-like particles ; glioblastoma ; convection-enhanced delivery ; tobacco mosaic virus ; bioconjugation ; doxorubicin ; drug delivery ; protein-based nanomaterials ; viral capsid ; VLPs ; hepatitis B virus capsid protein ; HBc ; viral self-assembly ; magnetic core ; HBcAg ; BmNPV bacmid ; nanobiomaterials ; Neospora caninum ; Neospora caninum profilin ; neosporosis ; silkworm expression system ; ZnS ; bio/inorganic hybrid materials ; hydrophobization ; polymer coupling ; virus ; tissue regeneration ; biomimetic nanocomposites ; phage display ; nano-vaccines ; HIV-1 Env trimers ; B-cell targeting ; intrastructural help ; VNPs ; Hsp60 ; IBD ; autoantibody ; inflammation ; diagnosis ; biosensor ; M13 bacteriophage ; color sensor ; energy generator ; piezoelectric ; self-assembly ; genetic engineering ; multi-array sensors ; hierarchical cluster analysis ; high selectivity ; piezoelectric materials ; organic materials ; biomaterials ; energy applications ; biomedical applications ; virus-based nanomaterials ; energy devices ; piezoelectric biomaterials ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 7
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    Therapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: The importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development.
    Keywords: Cannabis sativa (Cannabis) ; cannabinoids ; tetrahydrocannabinol (THC) ; cannabidiol (CBD) ; cannabinoid receptors (CB1 and CB2) ; Papaver somniferum (opium poppy) ; secondary metabolites ; ursolic acid ; NSCLC ; tumorsphere ; EGFR ; STAT3 ; MMP2 ; PD-L1 ; MAFLD ; tanshinone IIA ; phytochemical ; lipogenesis ; lipid accumulation ; LXRα ; malaria ; quinine ; chloroquine ; artemisinin ; onchocerciasis ; ivermectin ; moxidectin ; cancer ; vincristine ; vinblastine ; anabolic ; diabetes ; Duchenne muscular dystrophy ; β-ecdysone ; ecdysteroid ; ecdysterone ; Mas1 ; osteoporosis ; sarcopenia ; COVID-19 ; cardiometabolic diseases ; respiratory diseases ; natural product ; SARS-CoV-2 ; lung cancer ; United States Food and Drug Administration-approved drug ; natural remedy ; triterpenoid ; molecular ribbon ; Huisgen 1,3-dipolar cycloaddition ; amide bond ; multifunctional PEG3 derivative ; antimicrobial activity ; anti-HIV activity ; cytotoxicity ; supramolecular self-assembly ; phytocannabinoids ; cannabichromene ; thermos-TRPs ; TRPA1 ; α,α-dimethylheptyl effect ; betulinic acid ; BODIPY ; bevirimat ; cell-cycle ; fluorescent microscopy ; maturation inhibitor ; capsaicinoids ; endocannabinoidome ; microbiota ; overweight ; obesity ; food intake ; lipidomics ; metabolism ; alkaloids ; membrane fusion ; viral fusion inhibitor ; antiviral therapy ; curcumin ; cancer cells ; bioavailability ; curcumin derivatives ; curcumin analogues ; curcumin delivery systems ; natural product synthesis ; lignans ; inflammation ; NF-κB inhibition ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering
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  • 8
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    Bioactive Compounds from Natural Products: Separation, Characterization and Applications (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: Dear colleagues, This Special Issue aims to publish new and innovative research that could demonstrate the therapeutic potential of natural health products, through relevant in vitro and/or in vivo biological activities, to prevent or alleviate degenerative diseases. The interaction of natural health products with human microbiota represents an essential aspect, because it could modulate the microbial pattern and alleviate more of a chronic disease’s effects in the case of type 2 diabetes, cardiovascular dysfunctions, neurodegenerative diseases, and inflammatory colon pathologies. Additionally, you are invited to send research based on the effect of different extracts or functional foods used in degenerative pathologies and interactions with human microbiota. We aim to identify new data on in vitro/in vivo research that could demonstrate the bioavailability of natural compounds and the relationship with antioxidant/antimicrobial capacity. Modulated microbiota aspects are expected to be published based on the interaction with natural compounds, natural sweeteners, or other molecules that influence the colon health status.
    Keywords: in vitro callus ; cell suspension and root cultures ; biologically active substances ; ecdysteroids ; HPLC ; 1H NMR spectra ; Rhaponticum carthamoides ; Chaga ; medicinal fungi ; biomass yield ; mathematical modeling ; response surface methodology ; bioreactor culture ; mycelium ; antioxidant activity ; gamma irradiation ; Fomes fomentarius ; mushroom ; DPPH ; flavonoids ; polyphenols ; urinary infection ; in vitro ; Escherichia coli ; antimicrobial ; yellow onion skins ; extraction ; multifunctional ingredients ; Ficus carica L. ; ultrasonic enzyme co-assisted ; aqueous two-phase extraction ; UPLC-QTOF-MS/MS ; identification ; lactic acid fermentation ; betalain ; carotenoids ; red pepper ; beetroot ; carrot ; drying ; heat treatment ; seaweeds ; bioactive compounds ; food safety ; consumer health ; Cannabis sativa L. ; cannabinoids ; hemp oil ; UHPLC–PDA ; validation ; Cnidoscolus aconitifolius ; inflammation ; croton oil ; HL-60 ; phenols ; differentiation ; apoptosis ; transcriptome ; natural products ; bacteria ; downstream processing ; antibiotics ; isolation ; secondary metabolites ; pharmacognosy ; bioprospecting ; U. lactuca ; non-toxic solvents ; phenolics ; uropathogenic ; herbal medicines ; plant extract ; bioactive molecules ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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  • 9
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    Cosmetic Products and Industry (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-11
    Description: In Cosmetic Products and Industry - New Advances and Applications, we embark on a journey through the heart of cosmetic science, guided by the expertise of global luminaries in the field. This edited book is a collection of scholarly articles that traverse the scientific landscape of cosmetic innovation. From unraveling the mysteries of cosmetic ingredients to unveiling the fundamental technologies and research that breathe life into cosmetics, and from conjuring innovative concepts applied to formulations to ensure the safety of every ingredient, this volume includes contributions that push the boundaries of knowledge in cosmetic science.
    Keywords: cosmetics ; inflammation ; wound healing ; nanotechnology ; quality control ; tio2 ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering
    Language: English
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  • 10
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    Celebrating Applied Sciences Reaches 20,000 Articles Milestone (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: To celebrate the publication of 20,000 articles in Applied Sciences, we launched this Special Issue “Celebrating Applied Sciences Reaching Its 20,000 Article Milestone: Feature Papers of the Applied Biosciences and Bioengineering Section”. We have invited well-known experts in different areas of interest covered in “Applied Biosciences and Bioengineering” to submit their original research papers and review articles of the highest quality in celebrating together with our readers on this special occasion. This Special Issue has collected more than 10 papers featuring important and recent developments or achievements in biosciences and bioengineering, with a special emphasis on recently discovered techniques or applications.
    Keywords: biothiols ; blood plasma ; gold nanoparticles ; colorimetric probes ; chaperone system ; Hsp60 ; gastritis ; gastric dysplasia ; gastric carcinogenesis ; intestinal metaplasia ; LAMP ; Salmonella ; ISO 16140:2016 ; food-borne ; validation ; specificity ; sensitivity ; accuracy ; kit ; elderberry ; Sambucus nigra L. ; juice concentrate ; storage effect ; phenolic compounds ; berries ; anthocyanins’ stability ; polymeric color ; ABTS•+ antioxidant capacity ; endothelial glycocalyx ; inflammatory response ; fluid loading ; surgery ; post-operative ; albumin extravasation ; serum HSP90 ; gamma-delta T cells ; acute lymphoblastic leukaemia ; halophyte ; sea purslane ; minerals ; antioxidant activity ; novel ingredient ; epilepsy ; systems biology ; protein–protein interactions ; CNS ; Gibbs homology ; drug targets ; anti-epileptic drugs ; periodontitis ; inflammation ; oils ; volatile ; heart disease risk factors ; asthma ; chronic obstructive pulmonary disease ; COPD ; epithelial–mesenchymal trophic unit ; muco-microbiotic layer ; nanovesicles ; exosomes ; outer membrane vesicles ; microbiota ; spheroid ; organoid ; van der Waals force ; fluoropolymers ; adhesion ; microstamp ; extracellular vesicles ; liquid biopsy ; biomarkers ; tumor progression ; metastasis ; drug delivery ; halloysite ; nanoclay ; regenerative medicine ; tissue engineering ; wound healing ; stroke ; yoga ; balance disability ; depression ; levetiracetam ; critically ill patients ; population pharmacokinetic modeling ; simulated dosage schemes ; intensive care unit ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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