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  • pharmacokinetics  (2,025)
  • Lepidoptera  (1,054)
  • evolution  (720)
  • Springer  (3,765)
  • Royal Society  (22)
  • Goldsmiths Press  (5)
  • 1
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    Phone & Spear (2023)
    Goldsmiths Press | Goldsmiths Press
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    Publication Date: 2024-04-03
    Description: A visually striking intercultural exploration of the use of mobile phones in Aboriginal communities in Australia. Yuta is the Yolngu word for new. Phone & Spear: A Yuta Anthropology is a project inspired by the gloriously cheeky and deeply meaningful audiovisual media made with and circulated by mobile phones by an extended Aboriginal family in northern Australia. Building on a ten-year collaboration by the community-based arts collective Miyarrka Media, the project is an experiment in the anthropology of co-creation. It is a multivoiced portrait of an Indigenous society using mobile phones inventively to affirm connections to kin and country amid the difficult and often devastating circumstances of contemporary remote Aboriginal life. But this is not simply a book about Aboriginal art, mobile phones, and social renewal. If old anthropology understood its task as revealing one world to another, yuta anthropology is concerned with bringing different worlds into relationship. Following Yolngu social aesthetics—or what Miyarrka Media translate as “the law of feeling”—the book is a relational technology in its own right: an object that combines color, pattern, and story to bring once distant worlds into new sensuously mediated connections.
    Keywords: anthropology ; sociology ; cultural anthropology ; evolution ; sociology books ; historical nonfiction ; human evolution ; science books ; anthropology books ; history ; history books ; science ; social engineering ; homosapiens ; human evolution books ; culture ; language ; linguistics ; 21st century ; eastern europe ; how to ; food ; society ; philosophy ; psychology ; england ; race ; design ; cultural studies ; school ; education ; happiness ; social science ; reference ; music ; world history ; languages ; pop culture ; nature ; essays ; identity ; geography ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFV Ethical issues and debates ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 2
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    The Presence Project (2023)
    Goldsmiths Press | Goldsmiths Press
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    Publication Date: 2024-03-23
    Description: The influential Presence Project brought together an international group of collaborators in 2001 to investigate how technology can be used to increase the presence of older people in their local communities. This became a groundbreaking project for practice-based design research, exploring approaches and methods that have resonated since. The design team rejected a problem-solving approach, focusing instead on creating new and unusual situations for communication and insight. They introduced cutting-edge methods and developed challenging designs that they tested in the communities themselves. This book documents the Presence Project's development of key concepts in contemporary technology design, including cultural probes, design workbooks, and speculative design. Original Presence Project participants may have been surprised that the methods they invented became standard practice; the theme of the project was to break out of conventional approaches and try something radically new. With a new preface by Bill Gaver and an introduction by Phoebe Sengers, this reissue of The Presence Project gives readers a glimpse into the thinking behind this influential project and ideas about how to bring it to bear on today's design problems.
    Keywords: design ; coffee table book ; coffee table books ; art book ; color ; design books ; design book ; gifts for artists ; artist gifts ; gifts for artist ; business ; architecture ; innovation ; engineering ; mathematics ; education ; art ; philosophy ; creativity ; technology ; evolution ; psychology ; math ; programming ; chemistry ; marketing ; physics ; self help ; computers ; strategy ; problem solving ; work ; mba ; drawing ; economics ; career ; craft ; leadership ; business books ; management ; art history ; neuroscience ; how to ; nature ; culture ; creative ; geography ; sociology ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBC Engineering: general ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies
    Language: English
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  • 3
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    Stuart Hall (2023)
    Goldsmiths Press | Goldsmiths Press
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    Publication Date: 2024-04-07
    Description: Stuart Hall: Conversations, Projects and Legacies examines the career of the cultural studies pioneer, interrogating his influence and revealing lesser-known facets of his work. This collection of essays and photographs evaluates the legacies of his particular brand of cultural studies and demonstrates how other scholars and activists have utilised his thinking in their own research.
    Keywords: sociology ; anthropology ; political science ; evolution ; political philosophy ; government ; geopolitics ; human evolution ; world politics ; sociology books ; science books ; cultural anthropology ; political science books ; anthropology books ; history ; history books ; science ; political books ; politics ; social engineering ; homosapiens ; historical nonfiction ; international politics ; human evolution books ; philosophy ; marxism ; economics ; essays ; socialism ; technology ; biography ; classic ; law ; psychology ; death ; political theory ; education ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: English
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  • 4
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    Can Markets Solve Problems? (2023)
    Goldsmiths Press | Goldsmiths Press
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    Publication Date: 2024-03-29
    Description: A provocative analysis of market-based interventions into public problems and the consequences.Market-based interventions have been used in attempts to solve numerous public problems, from education to healthcare and from climate change to privacy. Scholars have responded persuasively through critiques of neoliberalism. In Can Markets Solve Problems? Daniel Neyland, Véra Ehrenstein, and Sveta Milyaeva propose a different route forward. There is no single entity knowable as “the market,” the authors argue. Instead, they examine in detail the devices, relations, and practices that underpin these market-based interventions. Drawing on recent work in science and technology studies (STS), each chapter focuses on a different intervention and critically explores the market sensibility around which it is organized. Trade and exchange, competition, property and ownership, and investment and return all become the focus of a thorough exploration of what it means to intervene in public problems, how problems are composed, and how solutions are continually reworked. Can Markets Solve Problems? offers the first book-length STS enquiry into markets and public problems. Weaving together rich empirical descriptions and conceptual discussions, the book provides in-depth insights into the workings of these markets, their continuous evolution, and the consequences. The result is a new avenue of critical inquiry that moves between the details of specific policies and the always-emerging, collective features of this landscape of intervention.
    Keywords: economics ; business ; philosophy ; economy ; political science ; political philosophy ; money ; government ; public policy ; strategy ; geopolitics ; business books ; behavioral economics ; economics books ; political science books ; political books ; politics ; world politics ; economic history ; economic development ; international politics ; finance ; ecology ; environment ; nature ; energy ; capitalism ; sociology ; marxism ; culture ; evolution ; society ; technology ; social ; investing ; psychology ; essays ; gardening ; biology ; health ; social science ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPF Political ideologies and movements ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPP Public administration
    Language: English
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  • 5
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    Futilitarianism (2023)
    Goldsmiths Press | Goldsmiths Press
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    Publication Date: 2024-03-29
    Description: A proposal for countering the futility of neoliberal existence to build an egalitarian, sustainable, and hopeful future.
    Keywords: philosophy ; capitalism ; political science ; political philosophy ; capital ; geopolitics ; philosophy books ; political science books ; political books ; politics ; economics books ; economic development ; economic history ; world politics ; international politics ; government ; economics ; sociology ; marxism ; socialism ; ecology ; finance ; culture ; business ; psychology ; economy ; social justice ; anthropology ; environment ; society ; globalization ; energy ; food ; essays ; social science ; money ; social ; evolution ; critical theory ; revolution ; feminism ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 6
    Electronic Resource
    Electronic Resource
    Human Interindividual Variability in Parameters Related to Health Risks (1999)
    Springer
    Risk analysis 19 (1999), S. 711-726 
    Details
    ISSN: 1539-6924
    Keywords: variability ; exposure ; susceptibility ; risk assessment ; pharmacokinetics ; pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This paper reviews existing data on the variability in parameters relevant for health risk analyses. We cover both exposure-related parameters and parameters related to individual susceptibility to toxicity. The toxicity/susceptibility data base under construction is part of a longer term research effort to lay the groundwork for quantitative distributional analyses of non-cancer toxic risks. These data are broken down into a variety of parameter types that encompass different portions of the pathway from external exposure to the production of biological responses. The discrete steps in this pathway, as we now conceive them, are: •Contact Rate (Breathing rates per body weight; fish consumption per body weight) •Uptake or Absorption as a Fraction of Intake or Contact Rate •General Systemic Availability Net of First Pass Elimination and Dilution via Distribution Volume (e.g., initial blood concentration per mg/kg of uptake) •Systemic Elimination (half life or clearance) •Active Site Concentration per Systemic Blood or Plasma Concentration •Physiological Parameter Change per Active Site Concentration (expressed as the dose required to make a given percentage change in different people, or the dose required to achieve some proportion of an individual's maximum response to the drug or toxicant) •Functional Reserve Capacity–Change in Baseline Physiological Parameter Needed to Produce a Biological Response or Pass a Criterion of Abnormal Function Comparison of the amounts of variability observed for the different parameter types suggests that appreciable variability is associated with the final step in the process–differences among people in “functional reserve capacity.” This has the implication that relevant information for estimating effective toxic susceptibility distributions may be gleaned by direct studies of the population distributions of key physiological parameters in people that are not exposed to the environmental and occupational toxicants that are thought to perturb those parameters. This is illustrated with some recent observations of the population distributions of Low Density Lipoprotein Cholesterol from the second and third National Health and Nutrition Examination Surveys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007045922532
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of the Uncertainty in an Oral Reference Dose for Methylmercury Due to Interindividual Variability in Pharmacokinetics (1999)
    Springer
    Risk analysis 19 (1999), S. 547-558 
    Details
    ISSN: 1539-6924
    Keywords: MeHg ; pharmacokinetics ; PBPK model ; variability ; risk assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract An analysis of the uncertainty in guidelines for the ingestion of methylmercury (MeHg) due to human pharmacokinetic variability was conducted using a physiologically based pharmacokinetic (PBPK) model that describes MeHg kinetics in the pregnant human and fetus. Two alternative derivations of an ingestion guideline for MeHg were considered: the U.S. Environmental Protection Agency reference dose (RfD) of 0.1 μg/kg/day derived from studies of an Iraqi grain poisoning episode, and the Agency for Toxic Substances and Disease Registry chronic oral minimal risk level (MRL) of 0.5 μg/kg/day based on studies of a fish-eating population in the Seychelles Islands. Calculation of an ingestion guideline for MeHg from either of these epidemiological studies requires calculation of a dose conversion factor (DCF) relating a hair mercury concentration to a chronic MeHg ingestion rate. To evaluate the uncertainty in this DCF across the population of U.S. women of child-bearing age, Monte Carlo analyses were performed in which distributions for each of the parameters in the PBPK model were randomly sampled 1000 times. The 1st and 5th percentiles of the resulting distribution of DCFs were a factor of 1.8 and 1.5 below the median, respectively. This estimate of variability is consistent with, but somewhat less than, previous analyses performed with empirical, one-compartment pharmacokinetic models. The use of a consistent factor in both guidelines of 1.5 for pharmacokinetic variability in the DCF, and keeping all other aspects of the derivations unchanged, would result in an RfD of 0.2 μg/kg/day and an MRL of 0.3 μg/kg/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007017116171
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  • 8
    Electronic Resource
    Electronic Resource
    Das Rückstandsverhalten von Chloramphenicol nach intramuskulärer Applikation beim Schwein (1985)
    Springer
    European journal of nutrition 24 (1985), S. 113-119 
    Details
    ISSN: 1436-6215
    Keywords: Chloramphenicol ; pharmacokinetics ; residue ; pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Residues of Chloramphenicol (CAP) were examined in 24 pigs after intramuscular injection of 30 mg CAP/kg body weight. Two pigs were slaughtered after 3, 6, 12,18, 24, 36 hours, 2, 3, 6, 10, 21 and 30 days, respectively. CAP-concentrations were determined in muscle, blood, urine, liver, kidney, bile, and fat. Methods used were gas-liquid chromatography and radioimmunoassay. Detection limits reached were 1−5 ppb. The concentration-time curves obtained reflected a long elimination phase and allowed only calculation of this half-life. Elimination half-life was estimated to be for muscle, blood and urine 160–170 hours, for kidney 310 and for bile 250 hours. Significant correlations were found to exist between CAP-concentrations in plasma and muscle. It appears that blood would be a good body fluid for monitoring CAP-residues in tissue.
    Notes: Zusammenfassung Zur Untersuchung des Rückstandsverhaltens von Chloramphenicol (CAP) wurden 24 Mastschweine, 24–28 Wochen alt, intramuskulär mit 30 mg CAP/kg Körpergewicht behandelt und je 2 Tiere nach 3, 6, 12, 18, 24, 36 Stunden, 2, 3, 6, 10, 21 und 30 Tagen geschlachtet. Die CAP-Gehalte in Muskulatur, Blut, Urin, Leber, Niere, Galle und Fett wurden gaschromatographisch und radioimmunologisch bestimmt. Die Nachweisgrenze beider Methoden liegt in Abhängigkeit von der Matrix zwischen 1 und 5 ppb. Die erhaltenen Kinetiken weisen eine terminale Elimination auf, deren Halbwertszeiten für Muskulatur, Blut und Urin ca. 160–170 Stunden, für Niere 310 Stunden und für Galle 250 Stunden betragen. Die CAP-Konzentration in Muskulatur und Blut weisen eine signifikante, lineare Korrelation auf. Blutuntersuchungen könnten deshalb als Screening-Methode bei umfangreichen Rückstandskontrollen eingesetzt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020458
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  • 9
    Electronic Resource
    Electronic Resource
    Enzymatic and pharmacokinetic studies on the metabolism of branched chain α-keto acids in the rat (1983)
    Springer
    European journal of nutrition 22 (1983), S. 14-26 
    Details
    ISSN: 1436-6215
    Keywords: branched chain α-keto acids ; 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate ; 3-methyl-2-oxobutyrate ; dehydrogenation ; transamination ; pharmacokinetics ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Michaelis-Konstanten und Aktivitäten von Dehydrogenasen und Transaminasen der drei verzweigten α-Ketosäuren Keto-Valin, Keto-Leucin und Keto-Isoleucin in Leber, Niere, Skeletmuskel und Gehirn von Ratten werden mitgeteilt. Nach oraler Zufuhr passieren nur 11–22% der Ketosäuren unverändert die Leber. Aus pharmakokinetischen und Resorptions-Untersuchungen erhaltene Blutspiegel an Ketosäuren werden zu den Michaelis-Konstanten in Beziehung gesetzt. Bei den geringen Konzentrationen an Ketosäuren nach oraler Zufuhr kann angenommen werden, daß die oxidativen Prozesse in den nichthepatischen Geweben über die Transaminierung überwiegen. Daten über die Wachstumseffizienz von verzweigtkettigen α-Ketosäuren im Vergleich zu den entsprechenden Aminosäuren stimmen mit dieser Vorstellung überein. Bei intravenöser Verabreichung müßten die Voraussetzungen für Transaminierung besser sein als nach oraler Zufuhr. Auf der Basis von Daten aus der Literatur werden die Übertragbarkeit unserer Befunde auf den Menschen und die verschiedenen Faktoren, welche die Effizienz der verzweigten α-Ketosäuren durch Einwirkung auf ihren Stoffwechsel beeinflussen können, diskutiert.
    Notes: Summary Miehaelis-constants and enzyme activities for dehydrogenation and transamination of the three branched chainα-keto acids in liver, kidney, skeletal muscle, and brain of rats are reported. After oral load only 11–22 % of the keto acids pass the liver unchanged. Blood levels in pharmacokinetic and absorption studies are related to the Michaelis-constants. At the low keto-acid concentrations after oral application, dehydrogenation in the non-hepatic tissues is supposed to prevail over transamination. Data on feed efficiency of branched chain α-keto acids reported in the literature support this view. The chance for transamination is better after intravenous administration. The transferability of our data to humans, and various factors influencing the efficiency of branched chain α-keto acids are discussed in connection with data reported in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020781
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  • 10
    Electronic Resource
    Electronic Resource
    Die Lage der Vogelsystematik (2000)
    Springer
    Journal of ornithology 141 (2000), S. 263-274 
    Details
    ISSN: 1439-0361
    Keywords: Systematics ; evolution ; anagenesis ; genealogy ; reference system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Verglichen mit anderen Tiergruppen, scheint die artliche Bestandsaufnahme der rezenten Vögel nahezu abgeschlossen zu sein. Doch ist das System der Vögel weiterhin umstritten und mit vielen Neuerungen konfrontiert. Die Gründe dafür liegen hauptsächlich in neuen, vor allem molekularbiologischen Methoden und in den unerwartet reichen Fossilfunden der jüngsten Zeit. Als Beispiele werden Altgaumenvögel, Kranichvögel, Ibisse, Flamingos, Mausvögel, Hopfe und Sperlingsvögel kurz behandelt. Die hier erzielten Fortschritte lassen die Befürchtung Stresemanns, die Großsystematik der Vögel sei mit den vorhandenen Methoden phylogenetisch nicht interpretierbar, zunächst als unbergründet erscheinen. Doch erwachsen einer solchen Interpretation andere Hindernisse, deren Bedeutung bisher zu wenig beachtet wurde, nämlich Parallelentwicklungen, die viel verbreiteter sind als gemeinhin angenommen. Ihre Häufigkeit lässt sich sogar mit evolutionsbiologischen Argumenten begründen. Es ist deshalb nicht zu erwarten, dass die Diskussionen um das „richtige“ System bald verstummen. Um dennoch die Eindeutigkeit der Information in nicht-systematischen Veröffentlichungen zu wahren, wird empfohlen ein etabliertes Referenzsystem auf Zeit zu wählen.
    Notes: Summary Unlike in most animal classes the inventory of extant species of the class Aves seems to be almost complete. Nevertheless avian systematics is challenged by many novelties and seems far from being settled. This is caused mainly by the application of novel methods of molecular analysis to phylogenetic problems and by the unexpectedly rich fossil record collected within the last 10–20 years. Examples from the Palaeognathae, Gruiformes, Threskiornithidae, Phoenicopteridae, Coliiformes, Upupiformes and Passeriformes are briefly treated. The progress in the field seems to disprove Stresemann's pessimistic view that the phylogeny of higher categories (orders) cannot be reconstructed by the available methods. However, phylogenetic interpretations are impeded by obstacles not considered by Stresemann and highly underestimated in most cases, namely by multiple independent developments leading to identical features. Frequent parallel developments are to be expected for theoretical evolutionary reasons. The diagnosis of such homoplasies can be extremely difficult or even impossible. Therefore we cannot expect the discussion about the “best” system of birds to end in the near future. Considering this dynamic situation in systematics, it is recommended to maintain unambiguousness of information in not strictly systematic publications by refering to a well established system as a temporally limited reference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02462236
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