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  • pharmacokinetics  (2,026)
  • Column liquid chromatography  (1,216)
  • Immunocytochemistry  (856)
  • growth  (686)
  • phosphorus  (682)
  • Springer  (5,449)
  • Frontiers Media SA  (4)
  • Taylor & Francis  (4)
  • Firenze University Press  (2)
  • 1
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    Physiological Adaptations to Swimming in Fish (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-03-31
    Description: Swimming is an integral part of the life history of many fish species as is intimately linked with their ability to express feeding and predator avoidance behaviors, habitat selection and environmental preferences, social and reproductive behaviors as well as migratory behaviors. Therefore, swimming is an important determinant factor of fitness in a true Darwinian sense and, not surprisingly, swimming performance has been often used as a measure of physiological fitness in fish. The main aim of this Research Topic is to showcase some of the current studies designed to improve our understanding of the physiological energetic and metabolic requirements of swimming and of the adaptive responses to swimming in fish.
    Keywords: QP1-981 ; GC1-1581 ; Q1-390 ; swimming economy ; performance ; fish ; swimming exercise ; growth ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 2
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    Tropical Forest Ecosystem Responses to Increasing Nutrient Availability (2021)
    Frontiers Media SA
    Details
    Publication Date: 2022-01-31
    Description: Deforestation and land use change have led to a strong reduction of tropical forest cover during the last decades. Climate change will amplify the pressure to the remaining refuges in the next years. In addition, tropical regions are facing increasing atmospheric inputs of nutrients, which will have unknown consequences for the structure and functioning of these systems, no matter if they are within protected areas or not. Even remote areas are expected to receive rising amounts of nutrients. The effects of higher rates of atmospheric nutrient deposition on the biological diversity and ecosystem functioning of tropical ecosystems are poorly understood and our knowledge of nutrient fluxes and nutrient limitation in tropical forest ecosystems is still limited. Yet, it will be of paramount importance to know the effects of increased nutrient availability to conserve these ecosystems with their biological and functional diversity. During the last years, research efforts have more and more focused on the understanding of the role of nutrients in tropical ecosystems and several coordinated projects have been established that study the effects of experimental nutrient addition. This Research Topic combines results from experiments and from observational studies with the aim to review and conclude on our current knowledge on the role of additional nutrients in ecosystems.
    Keywords: GB3-5030 ; Q1-390 ; experimental nutrient manipulation ; global change ; nitrogen ; CO2 ; nutrient limitation ; foliar nutrients ; biogeochemical cycles ; wood anatomy ; phosphorus
    Language: English
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  • 3
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    Implications of the Euro (2021)
    Taylor & Francis
    Details
    Publication Date: 2024-03-29
    Description: To date, critical analysis of the EMU project has largely been advanced from the centre-right spectrum of British politics. Comparable questions from the centre-left have failed to find a coherent voice. Although, the European fault-line cannot be characterized as a neat Left-Right issue there are noticeable divisions in opinion across British business, the trade union movement and within the Labour Party. Offering a unique insight into this key debate from the ‘centre-left’, eurosceptic view point, this book provides a rigorous analysis of all the salient economic and political issues of concern, such as: * the economics of a single currency * employment and social implications * sovereignty * political determination. The arguments presented in this volume highlight the emergence of a coherent alternative to deepening economic integration as a platform to build a just and equitable society. Contributions are drawn from leading academics, trade union leaders and prominent politicians, both from the Labour Party and the wider progressive Left in British politics. This informative and thought provoking book will be indispensable reading for students and practitioners in economics, politics and international relations, as well as those interested in this highly contentious topic.
    Keywords: single ; currency ; european ; union ; central ; bank ; exchange ; rate ; growth ; stability ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCB Macroeconomics::KCBM Monetary economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCL International economics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCB Macroeconomics::KCBM Monetary economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCL International economics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management
    Language: English
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  • 4
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    Energy, Wealth and Governance in the Caucasus and Central Asia (2021)
    Taylor & Francis
    Details
    Publication Date: 2024-03-28
    Description: Drawing upon recent progress in development economics and political science, the book provides fresh analysis of the Caucasus and Central Asia (CCA) countries transition to a market economy by tracing the impact of natural resource endowment. The book examines the synergies between energy-rich and energy-poor states and highlights the practical consequences of both well-managed and poorly-managed deployment of energy. Featuring contributions from prominent specialists on resource-driven economies, the book argues that unless CCA elites change the way in which they deploy natural resource, revenues regional development will fall short of its potential with possible disastrous consequences. The contributors apply the experience of the developing market economies to demonstrate that the region still holds considerable potential to become an important, stable supplier of raw materials and a source of industrial demand to the global economy. However, the CCA is equally likely to become a threat to the global economy as a consequence of the misuse of energy revenues to promote the interests of predatory political elites.
    Keywords: cca ; region ; resource ; poor ; countries ; growth ; collapse ; rent ; caspian ; sea ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 5
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    The Emerging Discipline of Quantitative Systems Pharmacology (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-01
    Description: In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.
    Keywords: RM1-950 ; Q1-390 ; Pharmacodynamics ; In-silico ; pharmacometrics ; Pharmaceutical R&D ; Computational Biology ; pharmacokinetics ; Quantitative Systems Pharmacology ; Modeling & Simulation ; Multi-scale modeling ; Systems Biology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 6
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    Novel Aspects of Nucleolar Functions in Plant Growth and Development (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: The nucleolus is a prominent nuclear domain that is common to eukaryotes. Since the nucleolus was first described in the 1830s, its identity had remained a mystery for longer than 100 years. Major advances in understanding of the nucleolus were achieved through electron microscopic and biochemical studies in the 1960s to 1970s followed by molecular biological studies. These studies finally established the view of the nucleolus that it is a large aggregate of RNA-protein complexes associated with the rRNA gene region of chromosome DNA, serving mainly as a site of ribosome biogenesis, where pre-rRNA transcription, pre-rRNA processing, and ribosome assembly occur. This function of the nucleolus appears to indicate that the nucleolus plays a constitutive and essential role in fundamental cellular activities by producing ribosomes. Recent research has shown, however, that the nucleolus is more dynamic and can have more specific and wider functions. In plants, nucleolar functions have been implicated in developmental regulations and environmental responses by accumulating pieces of evidence obtained mostly from genetic studies of nucleolar factor-related mutants. Comprehensive analysis of nucleolar proteins and molecular cytological characterization of sub-nucleolar and peri-nucelolar bodies have also provided new insights into behaviors and functions of the plant nucleolus.〈/p〉In this Research Topic, we would like to collect physiological and molecular links between the nucleolus to plant growth and development, shed light on novel aspects of nucleolar functions beyond its classical view, and stimulate research activities focusing on the nucleolus across various fields of plant science, including molecular biology, cell biology, genetics, developmental biology, physiology, and evolutionary biology.
    Keywords: QK1-989 ; Q1-390 ; environmental response ; development ; plant ; nucleolus ; growth ; ribosome biogenesis ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 7
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    Chapter The origins of the putting-out or domestic system of industrial production in England (2023)
    Firenze University Press | L’economia della conoscenza: innovazione, produttività e crescita economica nei secoli XIII-XVIII / The knowledge economy: innovation, productivity and economic growth, 13th to 18th century
    Details
    Publication Date: 2024-03-29
    Description: The putting-out system of production was a key feature of England’s woollen cloth industry and is regarded by many historians as a step along the road to capitalism. This paper considers the evolution of the industry in the late Middle Ages, the emergence of clothiers and their dependent out-workers and the nature of the relationship between the two groups. A detailed analysis follows of the growth, between 1475 and 1510, in the value of textile related debt litigation in the Court of Common Pleas, and revised estimates are given for the scale of the industry and the size of the workforce in the early-sixteenth century. Thus an assessment can be made of the importance of the putting-out system and its contribution to the success of the textile industry at that time.
    Keywords: clothier ; growth ; industry ; putting-out ; woollen cloth ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: English
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  • 8
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    Chapter Bookkeeping as a ‘key technology’ of pre-modern commerce. Its relevance for the eco-nomic development in Europe (2023)
    Firenze University Press
    Details
    Publication Date: 2024-03-29
    Description: It is the aim of this paper to analyse the importance of (double-entry) bookkeeping for the economic development in Europe and its possible indirect influence on economic growth. Being one of the most important commercial techniques of the European merchants double-entry bookkeeping stayed in close relationship to the expansion of trade. So, the distribution of different bookkeeping techniques all over Western and Central Europe, took place, on one hand, through the extensive commercial contacts of Italian merchant-bankers with merchants of regions north of the Alps and because of the need of many non-Italian merchants to consolidate their commercial knowledge in Italy through specific studies and/or through acquiring practical knowledge. On the other, treaties on (double-entry) bookkeeping supported its diffusion. The study analyses examples of ledgers as ‘mirrors’ of their enterprises’ activities, and it will be shown how such ledgers served as instruments for reducing various risks of entrepreneurial engagement. As a result it will become clear that the knowledge of the technique of double-entry bookkeeping was one of the preconditions of the commercial and, later on, the industrial expansion of the Europeans, which made a significant difference to other merchant cultures in the world.
    Keywords: Accounting ; (double-entry) bookkeeping ; commerce ; economic development ; entrepreneurial risk ; growth ; merchants’ treatises ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: English
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  • 9
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    Economic and Social Transformation in China (2021)
    Taylor & Francis
    Details
    Publication Date: 2023-09-12
    Description: The Center for China Studies is among China’s most influential think-tanks, and its China Studies Reports are read at the highest levels of government. Now for the first time, the most important of these reports is collected in book form in Eng, providing a fascinating insight into the challenges and opportunities for Chinese development and the government’s thinking on economic and social issues. Including comparative studies with developed and developing nations, analysis of past economic performance and future trends, and effects of demographic shifts such as population ageing and urbanization, this book is an essential collection of research and includes notes made by central party leaders. Compiled by the founder of the Center for China Studies, one of the country’s leading economists, this book is key to understanding Chinese development and the likely future path of government policy.
    Keywords: guojia ; tongjiju ; zhongguo ; tongji ; chubanshe ; chinas ; growth ; statistics ; press ; deng ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy
    Language: English
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  • 10
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    Urban Design Futures (2021)
    Taylor & Francis
    Details
    Publication Date: 2024-04-11
    Description: The last decade has seen the rise of urban design which has taken a central position in the new agendas for urban regeneration and renaissance. Urban design has moved from marginality to mainstream. The principles espoused by urban designers over the past thirty years are now accepted as key to a better urban environment and as we move towards greater sustainability, different ideas are emerging that are challenging some of the accepted urban design norms; urban design is at a watershed. Urban Design Futures presents essays from an international cast of authors to review progress and explore emerging ideas: should urban design reflect the future rather than recreate the past? What are the new driving forces that will shape urban living and hence urban design in the future? This book explores new concepts and points the way towards a series of urban design paradigms for the twenty-first century.
    Keywords: public ; realm ; space ; lan ; kwai ; fong ; corbusier ; smart ; growth ; renaissance ; thema EDItEUR::A The Arts::AM Architecture ; thema EDItEUR::A The Arts::AM Architecture::AMV Landscape architecture and design ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSD Urban communities
    Language: English
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