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  • 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous  (8)
  • 04. Solid Earth::04.08. Volcanology::04.08.04. Thermodynamics
  • Computational biology and bioinformatics
  • Nature Publishing Group  (4)
  • Elsevier Ltd.  (3)
  • The Geological Society of America  (3)
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  • 1
    facet.materialart.
    Unbekannt
    Lava flow hazard at Mount Etna (Italy): new data from a GIS-based study (2008)
    The Geological Society of America
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Invasion of inhabited areas and destruction of human property by lava flows represents the greatest volcanic hazard at Mount Etna (Italy) in the short term, based on the character of the historically documented eruptions of the volcano. Virtually all eruptions of Etna produce lava flows, which are more likely to cause damage when emitted from flank vents. Since 1600, more than sixty eruptions have occurred on the flanks of Etna. About half of these caused damage to, or destruction of, human property, dwellings and infrastructures, and at least two destroyed entire population centers. We present a quantitative analysis and evaluation of a new database containing numerical volcanological parameters of each post-1600 eruption, which allows us to quantify the hazard from future eruptions and to create a preliminary hazard zonation map divided into six zones. A total area of nearly 1400 km2 is considered vulnerable, which is home to 〉900,000 people. The greatest hazard is from voluminous and/or low-altitude flank eruptions, which during the historical period have occurred at irregular intervals of 120-400 years, the most recent in 1669. In the future, eruptions at higher elevations will occur much more frequently, at intervals of a few months to several decades, and many will cause damage in relatively limited areas. A recent increase in the intensity and frequency of eruptions indicate that the Etna volcanic system is presently more dynamic than during the past 330 years, and low-altitude flank eruptions have to be considered a realistic possibility for the near future.
    Beschreibung: Published
    Beschreibung: 189-208
    Beschreibung: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Beschreibung: 3.5. Geologia e storia dei sistemi vulcanici
    Beschreibung: 3.6. Fisica del vulcanismo
    Beschreibung: reserved
    Schlagwort(e): Mount Etna ; lava flows ; volcanic hazard ; GIS software ; hazard zonation ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    ARTIKEL (OA)
  • 2
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    Unbekannt
    Simultaneous magma and gas eruptions at three volcanoes in southern Italy: An earthquake trigger? (2009)
    The Geological Society of America
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: In September 2002, a series of tectonic earthquakes occurred north of Sicily, Italy, followed by three events of volcanic unrest within 150 km. On 28 October 2002, Mount Etna erupted; on 3 November 2002, submarine degassing occurred near Panarea Island; and on 28 December 2002, Stromboli Island erupted. All of these events were considered unusual: the Mount Etna northeast-rift eruption was the largest in 55 yr; the Panarea degassing was one of the strongest ever detected there; and the Stromboli eruption, which produced a landslide and tsunami, was the largest effusive eruption in 17 yr. Here we investigate the synchronous occurrence of these clustered events, and develop a possible explanatory model. We compute short-term earthquake-induced dynamic strain changes and compare them to long-term tectonic effects. Results suggest that the earthquake-induced strain changes exceeded annual tectonic strains by at least an order of magnitude. This agitation occurred in seconds, and may have induced fluid and gas pressure migration within the already active hydrothermal and magmatic systems.
    Beschreibung: This study was partly funded by the Deutsche Forschungsgemeinschaft (WA 1642/1-4), and Protezione Civile, project INGV-DPC-V2.
    Beschreibung: Published
    Beschreibung: 251-254
    Beschreibung: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Beschreibung: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Beschreibung: 3.1. Fisica dei terremoti
    Beschreibung: 3.2. Tettonica attiva
    Beschreibung: 3.6. Fisica del vulcanismo
    Beschreibung: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Beschreibung: 4.3. TTC - Scenari di pericolosità vulcanica
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): simultaneous magma eruptions ; earthquake trigger ; 04. Solid Earth::04.01. Earth Interior::04.01.99. General or miscellaneous ; 04. Solid Earth::04.01. Earth Interior::04.01.02. Geological and geophysical evidences of deep processes ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.07. Tectonophysics::04.07.99. General or miscellaneous ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.05. Stress ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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    ARTIKEL (OA)
  • 3
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    Unbekannt
    Comparison between different methodologies for detecting Radon in soil along an active fault: the case of the Pernicana fault system, Mt. Etna (Italy) (2009)
    Elsevier Ltd.
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Three different methodologies were used to measure Radon (222Rn) in soil, based on both passive and active detection system. The first technique consisted of Solid State Nuclear Track Detectors (SSNTD), CR-39 type, and allowed integrated measurements. The second one consisted of a portable device for short time measurements. The last consisted of a continuous measurement device for extended monitoring, placed in selected sites. Soil 222Rn activity was measured together with soil Thoron (220Rn) and soil carbon dioxide (CO2) efflux, and it was compared with the content of radionuclides in the rocks. Two different soil gas horizontal transects were investigated across the Pernicana fault system (NE flank of Mount Etna), from November 2006 to April 2007. The results obtained with the three methodologies are in a general agreement with each other and reflect the tectonic settings of the investigated study area. The lowest 222Rn values were recorded just on the fault plane, and relatively higher values were recorded a few tens of meters from the fault axis on both of its sides. This pattern could be explained as a dilution effect resulting from high rates of soil CO2 efflux. Time variations of 222Rn activity were mostly linked to atmospheric influences, whereas no significant correlation with the volcanic activity was observed. In order to further investigate regional radon distributions, spot measurements were made to identify sites having high Rn emissions that could subsequently be monitored for temporal radon variations.. SSNTD measurements allow for extended-duration monitoring of a relatively large number of sites, although with some loss of temporal resolution due to their long integration time. Continuous monitoring probes are optimal for detailed time monitoring, but because of their expense, they can best be used to complement the information acquired with SSNTD in a network of monitored sites..
    Beschreibung: Work founded by Istututo Nazionale di Geofisica e Vulcanologia and Dipartimento Protezione Civile, Italy
    Beschreibung: Published
    Beschreibung: 178-185
    Beschreibung: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Beschreibung: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Beschreibung: 3.2. Tettonica attiva
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Soil Radon and Thoron activity ; soil CO2 efflux ; Pernicana fault system ; volcano-tectonic monitoring ; Mount Etna ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.07. Radioactivity and isotopes ; 03. Hydrosphere::03.04. Chemical and biological::03.04.08. Instruments and techniques ; 04. Solid Earth::04.02. Exploration geophysics::04.02.01. Geochemical exploration ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.02. Exploration geophysics::04.02.07. Instruments and techniques ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.06. Rheology, friction, and structure of fault zones ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.04. Geology::04.04.11. Instruments and techniques ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.07. Tectonophysics::04.07.99. General or miscellaneous ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.08. Risk::05.08.99. General or miscellaneous ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    Spatial distribution of soil radon as a tool to recognize active faulting on an active volcano: the example of Mt. Etna (Italy) (2011)
    Elsevier Ltd.
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: This study concerns measurements of radon and thoron emissions from soil carried out in 2004 on the eastern flank of Mt. Etna, in a zone characterized by the presence of numerous seismogenic and aseismic faults. The statistical treatment of the geochemical data allowed recognizing anomaly thresholds for both parameters and producing distribution maps that highlighted a significant spatial correlation between soil gas anomalies and tectonic lineaments. The seismic activity occurring in and around the study area during 2004 was analyzed, producing maps of hypocentral depth and released seismic energy. Both radon and thoron anomalies were located in areas affected by relatively deep (5e10 km depth) seismic activity, while less evident correlation was found between soil gas anomalies and the released seismic energy. This study confirms that mapping the distribution of radon and thoron in soil gas can reveal hidden faults buried by recent soil cover or faults that are not clearly visible at the surface. The correlation between soil gas data and earthquakes depth and intensity can give some hints on the source of gas and/or on fault dynamics.
    Beschreibung: Published
    Beschreibung: 863-870
    Beschreibung: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Beschreibung: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Beschreibung: 3.1. Fisica dei terremoti
    Beschreibung: 4.5. Studi sul degassamento naturale e sui gas petroliferi
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): radon ; fault ; seismic hazard ; Etna ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.07. Radioactivity and isotopes ; 03. Hydrosphere::03.04. Chemical and biological::03.04.08. Instruments and techniques ; 04. Solid Earth::04.01. Earth Interior::04.01.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.07. Tectonophysics::04.07.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 05. General::05.08. Risk::05.08.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Unbekannt
    Dynamic feeder dyke systems in basaltic volcanoes: the exceptional example o fthe 1809 Etna eruption (Italy) (2015)
    Nature Publishing Group
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: In this paper, we describe the 1809 eruption of Mt. Etna, Italy, which represents one historical rare case in which it is possible to observe details of the internal structure of the feeder system. This is possible thanks to the presence of two large pit craters located in the middle of the eruptive fracture field that allow studying a section of the shallow feeder system. Along the walls of one of these craters, we analysed well-exposed cross sections of the uppermost 15–20 m of the feeder system and related volcanic products. Here, we describe the structure, morphology and lithology of this portion of the 1809 feeder system, including the host rock which conditioned the propagation of the dyke, and compare the results with other recent eruptions. Finally, we propose the dynamic model of the magma behaviour inside a laterally-propagating feeder dyke, demonstrating how this dynamic triggered important changes in the eruptive style (from effusive/Strombolian to phreatomagmatic) during the same eruption. Our results are also useful for hazard assessment related to the development of flank eruptions, potentially the most hazardous type of eruption from basaltic volcanoes in densely urbanized areas, such as Mt. Etna.
    Beschreibung: Published
    Beschreibung: 1-11
    Beschreibung: 2T. Tettonica attiva
    Beschreibung: 2V. Dinamiche di unrest e scenari pre-eruttivi
    Beschreibung: 3V. Dinamiche e scenari eruttivi
    Beschreibung: 4V. Vulcani e ambiente
    Beschreibung: 6A. Monitoraggio ambientale, sicurezza e territorio
    Beschreibung: N/A or not JCR
    Beschreibung: open
    Schlagwort(e): feeder dyke ; basaltic volcanoes ; flank eruptions ; Etna ; volcanic hazards ; sill ; volcanic rift ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.04. Thermodynamics ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    ARTIKEL (OA)
  • 6
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    Unbekannt
    Volcanological and structural evolution of the Ischia resurgent caldera (Italy) over the past 10 k.y. (2010)
    The Geological Society of America
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Volcanic activity on the island of Ischia in the past 10 k.y. has included both effusive and explosive eruptions, mainly in the eastern sector of the island. Vent location, eruption dynamics, transport mechanisms, and depositional processes have been reconstructed for each recognized lithostratigraphic unit. Periods of quiescence have alternated with periods of very intense volcanism, mainly concentrated at ca. 5.5 ka and over the past 2.9 k.y. Volcanism has not been continuous, but it has been strongly infl uenced by the mechanism of a resurgence phenomenon that has affected the island since ca. 33 ka. Therefore, it has been hypothesized that magma intrusion and uplift events have occurred intermittently. In the past 5.5 k.y., volcanic activity has been invariably accompanied by the emplacement of slope instability–related deposits, illustrating that the slope instability was also induced by reactivation of vertical movements, likely related to resurgence.
    Beschreibung: Published
    Beschreibung: 193-239
    Beschreibung: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Beschreibung: reserved
    Schlagwort(e): volcanological ; Ischia resurgent ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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  • 7
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    Unbekannt
    Lava flow hazards at Mount Etna: constraints imposed by eruptive history and numerical simulations (2014)
    Nature Publishing Group
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Improving lava flow hazard assessment is one of the most important and challenging fields of volcanology, and has an immediate and practical impact on society. Here, we present a methodology for the quantitative assessment of lava flow hazards based on a combination of field data, numerical simulations and probability analyses. With the extensive data available on historic eruptions of Mt. Etna, going back over 2000 years, it has been possible to construct two hazard maps, one for flank and the other for summit eruptions, allowing a quantitative analysis of the most likely future courses of lava flows. The effective use of hazard maps of Etna may help in minimizing the damage from volcanic eruptions through correct land use in densely urbanized area with a population of almost one million people. Although this study was conducted on Mt. Etna, the approach used is designed to be applicable to other volcanic areas.
    Beschreibung: This work was developed within the framework of TecnoLab, the Laboratory for Technological Advance in Volcano Geophysics organized by INGV-CT, DIEES-UNICT, and DMI-UNICT.
    Beschreibung: Published
    Beschreibung: 3493
    Beschreibung: 1V. Storia e struttura dei sistemi vulcanici
    Beschreibung: 2V. Dinamiche di unrest e scenari pre-eruttivi
    Beschreibung: 3V. Dinamiche e scenari eruttivi
    Beschreibung: 4V. Vulcani e ambiente
    Beschreibung: 6A. Monitoraggio ambientale, sicurezza e territorio
    Beschreibung: 3IT. Calcolo scientifico e sistemi informatici
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): Lava flow hazard ; Etna ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 05. General::05.01. Computational geophysics::05.01.99. General or miscellaneous ; 05. General::05.02. Data dissemination::05.02.99. General or miscellaneous ; 05. General::05.08. Risk::05.08.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    A tool for evaluating geothermal power exploitability and its application to Ischia, Southern Italy (2015)
    Elsevier Ltd.
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: The paper proposes a method to evaluate the potential for electric power production at any site of possible geothermal interest. Accounting for geological data of the reservoirs, the method allows the computation of the available electrical power of the investigated site. Electrical energy production from geothermal sources is realized through different techniques, such as single flash and double flash, dry steam, and binary ORC plants. The technique chosen to be the most productive is determined by analyzing a specific range of geofluid properties, mainly temperature and pressure. Moreover, each plant typology has a global efficiency that may be correlated to geofluid enthalpy by empiric relations available in literature. The proposed evaluation method brings together all these correlations, yielding the power availability from a geosource, once its temperature and pressure are known. The method takes as input the geofluid available flow rate, its pressure, temperature and non-condensable gas content. It defines the best plant option from these parameters, calculates its global efficiency and finally returns the actual available power. For sites of geothermic interest, such as the volcanic island of Ischia in Southern Italy, the results of the application of this new method clearly highlight the most suitable zones for power plants installations.
    Beschreibung: Published
    Beschreibung: 303-312
    Beschreibung: 4V. Vulcani e ambiente
    Beschreibung: 5A. Energia e georisorse
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): Geothermal power plants Geothermal exergy Ischia volcanic island ; 03. Hydrosphere::03.04. Chemical and biological::03.04.03. Chemistry of waters ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.02. Exploration geophysics::04.02.01. Geochemical exploration ; 04. Solid Earth::04.02. Exploration geophysics::04.02.03. Heat flow ; 04. Solid Earth::04.08. Volcanology::04.08.04. Thermodynamics
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    A novel approach to estimate the eruptive potential and probability in open conduit volcanoes (2016)
    Nature Publishing Group
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: In open conduit volcanoes, volatile-rich magma continuously enters into the feeding system nevertheless the eruptive activity occurs intermittently. From a practical perspective, the continuous steady input of magma in the feeding system is not able to produce eruptive events alone, but rather surplus of magma inputs are required to trigger the eruptive activity. The greater the amount of surplus of magma within the feeding system, the higher is the eruptive probability.Despite this observation, eruptive potential evaluations are commonly based on the regular magma supply, and in eruptive probability evaluations, generally any magma input has the same weight. Conversely, herein we present a novel approach based on the quantification of surplus of magma progressively intruded in the feeding system. To quantify the surplus of magma, we suggest to process temporal series of measurable parameters linked to the magma supply. We successfully performed a practical application on Mt Etna using the soil CO2 flux recorded over ten years.
    Beschreibung: Published
    Beschreibung: 30471
    Beschreibung: 2V. Dinamiche di unrest e scenari pre-eruttivi
    Beschreibung: 5V. Sorveglianza vulcanica ed emergenze
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): eruptive potential ; eruptive probability ; open conduit volcanoes ; Etna ; Soil CO2 flux ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.08. Risk::05.08.01. Environmental risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 10
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    Highly conserved molecular pathways, including Wnt signaling, promote functional recovery from spinal cord injury in lampreys (2018)
    Nature Publishing Group
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: © The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 742, doi:10.1038/s41598-017-18757-1.
    Beschreibung: In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic connections, and consequently function. Unlike mammals, lampreys are vertebrates that undergo spontaneous regeneration and achieve functional recovery after SCI. Therefore our goal was to determine the complete transcriptional responses that occur after SCI in lampreys and to identify deeply conserved pathways that promote regeneration. We performed RNA-Seq on lamprey spinal cord and brain throughout the course of functional recovery. We describe complex transcriptional responses in the injured spinal cord, and somewhat surprisingly, also in the brain. Transcriptional responses to SCI in lampreys included transcription factor networks that promote peripheral nerve regeneration in mammals such as Atf3 and Jun. Furthermore, a number of highly conserved axon guidance, extracellular matrix, and proliferation genes were also differentially expressed after SCI in lampreys. Strikingly, ~3% of differentially expressed transcripts belonged to the Wnt pathways. These included members of the Wnt and Frizzled gene families, and genes involved in downstream signaling. Pharmacological inhibition of Wnt signaling inhibited functional recovery, confirming a critical role for this pathway. These data indicate that molecular signals present in mammals are also involved in regeneration in lampreys, supporting translational relevance of the model.
    Beschreibung: We gratefully acknowledge support from the National Institutes of Health (R03NS078519 to OB; R01GM104123 to JJS; R01NS078165 to JRM), The Feinstein Institute for Medical Research and The Marine Biological Laboratory, including the Charles Evans Foundation Research Award, the Albert and Ellen Grass Foundation Faculty Research Award, and The Eugene and Millicent Bell Fellowship Fund in Tissue Engineering.
    Schlagwort(e): Computational biology and bioinformatics ; Gene expression ; Spinal cord injury
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Standort Signatur Erwartet Verfügbarkeit
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    ARTIKEL (OA)
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