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  • XFELP-type ATPasesligand screeningserial femtosecond crystallography  (2)
  • 05. General::05.07. Space and Planetary sciences::05.07.02. Space weather  (1)
  • International Union of Crystallography (IUCr)  (2)
  • American Institute of Physics  (1)
  • Cell Press
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  • 1
    Publikationsdatum: 2015-06-13
    Beschreibung: Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently, membrane proteins are targeted by a large number of currently approved drugs. Understanding their functions and molecular mechanisms is greatly dependent on structural information, not least on complexes with functionally or medically important ligands. Structure determination, however, is hampered by the difficulty of obtaining well diffracting, macroscopic crystals. Here, the feasibility of X-ray free-electron-laser-based serial femtosecond crystallography (SFX) for the structure determination of membrane protein–ligand complexes using microcrystals of various native-source and recombinant P-type ATPase complexes is demonstrated. The data reveal the binding sites of a variety of ligands, including lipids and inhibitors such as the hallmark P-type ATPase inhibitor orthovanadate. By analyzing the resolution dependence of ligand densities and overall model qualities, SFX data quality metrics as well as suitable refinement procedures are discussed. Even at relatively low resolution and multiplicity, the identification of ligands can be demonstrated. This makes SFX a useful tool for ligand screening and thus for unravelling the molecular mechanisms of biologically active proteins.
    Schlagwort(e): XFELP-type ATPasesligand screeningserial femtosecond crystallography
    Digitale ISSN: 2052-2525
    Thema: Geologie und Paläontologie , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    International Union of Crystallography (IUCr)
    In: IUCrJ
    Publikationsdatum: 2015-07-01
    Schlagwort(e): XFELP-type ATPasesligand screeningserial femtosecond crystallography
    Digitale ISSN: 2052-2525
    Thema: Geologie und Paläontologie , Physik
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Publikationsdatum: 2017-04-04
    Beschreibung: COST (Co-operation in the field of Scientific and Technical Research) is an important instrument supporting co-operation among scientists and researchers across Europe now joining 35 member countries. Scientific projects in the COST framework are called COST Actions and have the objectives embodied in their respective Memorandum of Understanding (MoU). The main objectives of the COST Actions within the European ionospheric and radio propagation community have been: to study the influence of upper atmospheric conditions on terrestrial and Earthspace communications, to develop methods and techniques to improve existing and generate new ionospheric and propagation models over Europe for telecommunication and navigation applications and to transfer the results to the appropriate national and international organizations, institutions and industry dealing with the modern communication systems. This paper summarises in brief the background and historical context of four ionospheric COST Actions and outlines their main objectives and results. In addition, the paper discusses the dissemination of the results and the collaboration among the participating institutions and researchers.
    Beschreibung: DRS Codem Systems Ball Aerospace Corporation University of Massachusetts Lowell
    Beschreibung: Published
    Beschreibung: Lowell, Massachusetts, U.S.A., April 29, 2007
    Beschreibung: 3.9. Fisica della magnetosfera, ionosfera e meteorologia spaziale
    Beschreibung: open
    Schlagwort(e): Physics of the Ionosphere ; 01. Atmosphere::01.02. Ionosphere::01.02.99. General or miscellaneous ; 05. General::05.07. Space and Planetary sciences::05.07.02. Space weather
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: Conference paper
    Standort Signatur Erwartet Verfügbarkeit
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