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  • 04. Solid Earth::04.04. Geology::04.04.03. Geomorphology
  • Genetics
  • Palaeoclimate
  • Frontiers Media SA  (17)
  • Routledge  (5)
  • Nature Publishing Group  (4)
  • American Chemical Society
  • Public Library of Science (PLoS)
Collection
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Years
  • 1
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    New treatment perspectives in autism spectrum disorders (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.
    Keywords: R5-920 ; RJ1-570 ; Clinical Trial ; mouse model ; neurodevelopmental disorder ; Genetics ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Chapter 3 Anticipating Prevention (2021)
    Taylor & Francis | Anthropologies of Cancer in Transnational Worlds | Routledge
    Details
    Publication Date: 2023-09-12
    Description: Cancer is a transnational condition involving the unprecedented flow of health information, technologies, and people across national borders. Such movement raises questions about the nature of therapeutic citizenship, how and where structurally vulnerable populations obtain care, and the political geography of blame associated with this disease. This volume brings together cutting-edge anthropological research carried out across North and South America, Europe, Africa and Asia, representing low-, middle- and high-resource countries with a diversity of national health care systems. Contributors ethnographically map the varied nature of cancer experiences and articulate the multiplicity of meanings that survivorship, risk, charity and care entail. They explore institutional frameworks shaping local responses to cancer and underlying political forces and structural variables that frame individual experiences. Of particular concern is the need to interrogate underlying assumptions of research designs that may lead to the naturalizing of hidden agendas or intentions. Running throughout the chapters, moreover, are considerations of moral and ethical issues related to cancer treatment and research. Thematic emphases include the importance of local biologies in the framing of cancer diagnosis and treatment protocols, uncertainty and ambiguity in definitions of biosociality, shifting definitions of patienthood, and the sociality of care and support.
    Keywords: cancer ; anthropological research ; health ; anthropology ; cancer ; anthropological research ; health ; anthropology ; Brazil ; Breast cancer ; Genetic testing ; Genetics ; Oncogenomics ; Public health ; São Paulo ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBS Medical sociology ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSX Human biology::PSXM Medical anthropology
    Language: English
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  • 3
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    Host Genetics in Viral Pathogenesis and Controls (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords:  Viruses ; Genetics ; Host-virus interaction ; Epidemiology ; Immunity ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 4
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    The Routledge History of Disease (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-02
    Description: The Routledge History of Disease draws on innovative scholarship in the history of medicine to explore the challenges involved in writing about health and disease throughout the past and across the globe, presenting a varied range of case studies and perspectives on the patterns, technologies and narratives of disease that can be identified in the past and that continue to influence our present. Organized thematically, chapters examine particular forms and conceptualizations of disease, covering subjects from leprosy in medieval Europe and cancer screening practices in twentieth-century USA to the ayurvedic tradition in ancient India and the pioneering studies of mental illness that took place in nineteenth-century Paris, as well as discussing the various sources and methods that can be used to understand the social and cultural contexts of disease. Chapter 24 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9781315543420.ch24
    Keywords: Abigail Woods ; Akihito Suzuki ; Alannah Tomkins ; Arthur W. Frank ; Brian Hurwitz ; Catherine Rider ; Christoph Gradmann ; contagion ; David Cantor ; David M. Turner ; Dominik Wujastyk ; disability ; Elena Carrera ; Elma Brenner ; Fay Bound Alberti ; Genetics ; Havi Carel ; Helen Bynum ; Jana Funke ; Julie Anderson ; Katherine Foxhall ; Katrina Ford ; Leprosy ; Mark Harrison ; Martin D. Moore ; Michael Worboys ; Mnica García ; Pandemic ; plague ; Richard A. McKay ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
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  • 5
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    Neuroscience of Human Attachment (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: Attachment is a biologically emotion regulation based system guiding cognitive and emotional processes with respect to intimate and significant relationships. Secure relationships promote infants’ exploration of the world and expand their mastery of the environment. Adverse attachment experiences like, maltreatment, loss, and separation have long been known to have enduring unfavorable effects on human mental health. Research on the neurobiological basis of attachment started with animal studies focusing on emotional deprivation and its behavioral, molecular and endocrine consequences. The present book presents an interdisciplinary synthesis of existing knowledge and new perspectives on the human neuroscience of attachment, showing the tremendous development of this field. The following chapters include innovative studies that are representative of the broad spectrum of current approaches. These involve both differing neurobiological types of substrates using measures like fMRI, EEG, psychophysiology, endocrine parameters, and genetic polymorphisms, as well as psychometric approaches to classify attachment patterns in individuals. The findings we have acquired in the meanwhile on the neural substrates of attachment in healthy subjects lay the foundation of studies with clinical groups. The final section of the book addresses evidence on changes in the functioning of these neural substrates in psychopathology.
    Keywords: RC321-571 ; Q1-390 ; fMRI ; Neuroscience ; social cognition ; Brain activity ; EEG ; Genetics ; Attachment ; Attachment representation ; Psychopathology ; Neurophysiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 6
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    The Parallel March of Asthma and Allergy in Childhood: A Multi-Perspective Approach (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It has not been yet clarified whether allergy and asthma are part of the same condition or they follow a parallel path. This Research Topic aims to try and put some light in this parallel march going through crucial topics: from prenatal events to later risk factors such as obesity; and from basic immunology to immunotherapy, both subcutaneous and sublingual. We hope the readers can infer their own conclusions as what is first: egg or chicken.
    Keywords: R5-920 ; RJ1-570 ; Allergy ; Obesity ; Food allergy ; Oxidative stress ; Mediterranean diet ; Immunotherapy ; Genetics ; Epidemiology ; Asthma ; Atopy ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    Translational Research for Cucurbit Molecular Breeding: Traits, Markers, and Genes (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Cucurbits ; Molecular Breeding ; Marker-Trait Association ; Genetics ; Translational Genomics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 8
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    Why vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Despite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens.
    Keywords: R5-920 ; RC581-607 ; QR1-502 ; Q1-390 ; influenza ; HIV ; Malaria ; Infectious Disease ; Genetics ; Vaccine ; HCV ; immunology ; bic Book Industry Communication::M Medicine
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  • 9
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    Machine Learning Techniques on Gene Function Prediction (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Machine learning ; Genetics ; Bioinformatics ; Feature selection ; Deep learning ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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  • 10
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    Refining Prevention: Genetic and Epigenetic Contributions (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-03-29
    Description: Currently, most prevention efforts are framed as universal interventions. However, despite the demonstrated efficacy of many prevention programs, variability in response is the rule with some participants responding very little and others accounting for the bulk of the positive impact of the program. Better understanding the processes associated with better and worse response to prevention is a critical first step in refining and adapting existing programs, or alternatively designing new prevention programs with enhanced outcomes. Because vulnerabilities to substance use, emotional problems, risky sexual behavior and other behavioral problems are influenced by a combination of environmental, genetic, and epigenetic factors, mediated in part through psychological processes (Kreek et al., 2005; Rutter et al., 2006), the study of genetic and epigenetic vulnerability and susceptibility factors provides an important starting point for efforts to address this critical need. A growing body of research on differential genetic susceptibility indicates that efforts to enhance prevention impact may benefit from consideration of the contribution of individualgenetic differences to treatment response (Brody et al., 2013). In addition, the recent expansion of genetic research to include a focus on epigenetic change provides considerable promise for the development of indicated prevention and individually tailored prevention efforts. However, before this promise can be realized, a number of theoretical and practical challenges remain. Thus, through this special section, we provide a foundation for a new era of prevention research in which the principles of prevention science are combined with genomic science. In the current special section we bring together authors to deal with genetic and epigenetically driven processes relevant to depression, substance abuse, and sexual risk taking. Together they comment on, and provide data relevant to, assessment, research and statistical methods, The papers help to inform the development of a new generation of prevention programs that go beyond universal programs and sensitively target key processes while providing greater precision regarding prediction of population-level impact.
    Keywords: BF1-990 ; Q1-390 ; substance use ; translation ; Genetics ; Mental Health ; prevention ; epigenetics ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 11
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    The Genetic and Environmental Basis for Diseases in Understudied Populations (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Genetics ; Disease ; Population Genetics ; Indigenous populations ; GWAS ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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  • 12
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    Genetics and Genomics of Polyploid Plants (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: polyploid ; Genetics ; Genomics ; evolution ; Genotype by environment (G × E) ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 13
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    Vascular Inflammation in Systemic Autoimmunity (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: Plasticity and dynamism characterize the immune system as a tissue-integrating network with defensive functions. Blood and lymphatic vessel trees constitute the most evident and intuitive physical platform for the development of the net of interactions between immune cells, body tissues and foreign agents. Moreover vessel repair and immune patrolling are intimately linked physiological functions with common evolutionary roots. Not surprisingly variable degrees of vascular inflammation are often detectable in the setting of systemic inflammation and autoimmunity, whereas research in the field of cardiovascular pathology is progressively converging towards the identification of a common inflammatory background. The definition of the role of vascular inflammation in causing, sustaining and/or predicting the development of systemic autoimmunity constitute a challenging, unexplored frontier towards the development of a new generation of treatments and a better patient care.
    Keywords: R5-920 ; RC581-607 ; Autoimmunity ; remodeling ; Vasculitis ; T-Lymphocytes ; Pathogenesis ; Neutrophils ; vascular inflammation ; Genetics ; platelets ; Endothelium ; bic Book Industry Communication::M Medicine
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  • 14
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    Collaborative Efforts for Understanding the Human Brain (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brain ; Neuroscience ; collaboration ; brain imaging ; MRI ; fMRI ; EEG ; Genetics ; imaging genetics ; Software ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 15
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    Improving Animal Welfare through Genetic Selection (2021)
    Frontiers Media SA
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    Publication Date: 2024-04-05
    Description: In livestock species, breeding goals are aimed primarily at improvement of production traits. However, there are a number of examples where selection for high production efficiency has resulted in reduced welfare through unfavorable outcomes in health and fitness characteristics. These effects raise questions about what is ethically acceptable in animal breeding. Welfare problems may be experienced when physiological balance is disturbed by genetic selection for high production alone, by a mismatch between the environmental challenges and the range of coping responses available to an animal, or from a mismatch between the animal’s needs and their degree of satisfaction. This may be resolved by either improving the environment to support the animal, but also by providing the animal, through genetic selection, with means to adapt to the production environment. The Standing Committee of the European Convention for the Protection of Animals kept for Farming Purposes emphasizes that breeding goals should include health and welfare. The Farm Animal Welfare Council pleas for a greater emphasis in breeding programs on traits associated with good welfare. However, although breeding goals in most farm animal species have been broadened beyond production traits to include functional traits, behavioral traits are rarely included despite their potential to improve animal production and welfare. It is the goal of the present Research Topic to bring together experimental and theoretical research focusing on the genetics of welfare traits and the possibility to improve animal welfare through selection. This topic presents an overview of the relationship between selection for high production and livestock robustness, examples of improving robustness through the introduction of novel traits in livestock breeding, and a discussion on selection methods to address welfare issues. The discussion on sustainability of breeding practices is very alive today and will remain to be an important part of the debate in the future.
    Keywords: QH426-470 ; Q1-390 ; animal breeding ; livestock improvement ; selection ; livestock production ; Genetics ; welfare ; sustainable agriculture ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 16
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    The Neurobiology and Genetics of Gilles de la Tourette Syndrome: New Avenues through Large-Scale Collaborative Projects (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-03-30
    Description: Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as histamine and glutamate. For a very long time, efforts to elucidate the etiology and pathophysiology of TS have been fragmented and hampered by low statistical power. Finally, after more than two decades of active research aiming to identify the etiology and pathophysiology of TS, we are on the verge of a new era, promising exciting and rapid discoveries in the field. Investigators from around the world, representing multiple disciplines and scientific approaches, are joining their efforts in large-scale initiatives supported both by European Union and US National funding agencies, such as the European-funded EMTICS, TACTICS, and TSGeneSEE consortia, the Marie Curie Initial Training Network TS-EUROTRAIN and the European Society for the Study of TS joining forces with the NIH-funded TSAICG, GGRI, and Tic Genetics consortia. Importantly, all these initiatives are supported by TS patient support and advocacy groups. Multiple resources are being consolidated and coming together to serve the study of TS, including large well-characterized patient cohorts, and specialized epidemiological databases, such as the unique resource of the Netherlands Twin Register. This research topic showcases current large-scale collaborative efforts aiming to elucidate the genetic and neurobiological background of TS, through diverse approaches; from genomewide association studies aiming to identify common variants associated to the disorder to neuroimaging studies and animal models. Furthermore, current approaches on the clinical assessment and management of the disorder are presented. Propelled by the gradual availability of large scale TS cohorts, novel methodologies, and importantly, sheer enthusiasm by multiple researchers working together across different countries, the new era of the neurobiology of TS holds the promise to identify novel targets for improved therapies.
    Keywords: R5-920 ; RC321-571 ; RC435-571 ; RJ1-570 ; Q1-390 ; Treatment ; clinical research ; Neurobiology ; Collaborative studies ; Gilles de la Tourette syndrome ; Genetics
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  • 17
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    Society, Organizations and the Brain: building towards a unified cognitive neuroscience perspective (2021)
    Frontiers Media SA
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    Publication Date: 2024-04-05
    Description: This e-book brings together scholars in both the neurosciences and organizational sciences who have adopted various approaches to study the cognitive mechanisms mediating the social behavior that we see within organizations. Such an approach has been termed by ourselves, and others, as ‘organisational cognitive neuroscience’. In recent years there has been a veritable increase in studies that have explored the cognitive mechanisms driving such behaviors, and much progress has been made in understanding the neural underpinnings of processes such as financial exchange, risk awareness and even leadership. However, while these studies are informative and add to our understanding of human cognition they fall short of providing evidence-based recommendations for practice. Specifically, we address the broader issue of how the neuroscientific study of such core social behaviors can be used to improve the very way that we work. To address these gaps in our understanding the chapters in this book serve as a platform that allows scholars in both the neurosciences and the organizational sciences to highlight the work that spans across these two fields. The consolidation of these two fields also serves to highlight the utility of a singular organizational cognitive neuroscience. This is a fundamentally important outcome of the book as the application of neuroscience to address economically relevant behaviors has seen a variety of fields evolve in their own right, such as neuromarketing, neuroeconomics and so forth. The use of neuro-scientific technologies,in particular fMRI, has indeed led to a bewildering (and somewhat suffocating) proliferation of new approaches, however, the speed of such developments demands that we must proceed carefully with such ventures or risk some fundamental mistakes. The book that you now hold will consolidates these new neuroscience based approaches and in doing so highlight the importance of this approach in helping us to understand human social behavior in general. Taken together the chapters provide a framework for scholars within the neurosciences who wish to explore the further the opportunities that the study of organisational behavior may provide.
    Keywords: RC321-571 ; Q1-390 ; Brain ; Neuroscience ; organisations ; Functional Brain imaging ; Genetics ; neuroeconomics ; neuromarketing ; MEG ; Organisational Cognitive Neuroscience society ; Marketing ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 18
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    Chapter 28 Genomics in emerging and developing economies (2021)
    Taylor & Francis | Routledge Handbook of Genomics, Health and Society | Routledge
    Details
    Publication Date: 2022-05-03
    Description: Low and middle-income countries have become a site of increasing research interest and investment with the transnational expansion and spread of genomic knowledge and technologies (Kumar 2012, Seguin et al. 2008). This reflects a dynamic terrain in which genomics is being harnessed to address a range of healthcare challenges.
    Keywords: genomics ; developing economies ; Africa ; Brazil ; Genetics ; Haplotype ; Public health ; Senegal ; Sickle cell disease ; bic Book Industry Communication::J Society & social sciences
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  • 19
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    Chapter 13 The value of the imagined biological in policy and society (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-07
    Description: Attending the World Economic Forum this past week, I was struck by two trends. The first was that brain research has emerged as a hot topic. Not only was brain science or brain health a new theme at the meeting, research on the brain emerged in discussions about next generation computing, global cooperation, and even models of economic development as well as being linked to mental health or mindfulness. In a meeting frequented largely by economists and business leaders, I was surprised by the number of non-scientists who have become enchanted by brain science. Clearly this is the era of the brain, with mental health now part of a much broader discussion.
    Keywords: policy ; society ; mental health ; Biology ; Epigenetics ; Genetics ; Genome ; Neuroscience ; Plastic ; Social policy ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::M Medicine and Nursing
    Language: English
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  • 20
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    Chapter 24 Before HIV (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-02
    Description: The Routledge History of Disease draws on innovative scholarship in the history of medicine to explore the challenges involved in writing about health and disease throughout the past and across the globe, presenting a varied range of case studies and perspectives on the patterns, technologies and narratives of disease that can be identified in the past and that continue to influence our present. Organized thematically, chapters examine particular forms and conceptualizations of disease, covering subjects from leprosy in medieval Europe and cancer screening practices in twentieth-century USA to the ayurvedic tradition in ancient India and the pioneering studies of mental illness that took place in nineteenth-century Paris, as well as discussing the various sources and methods that can be used to understand the social and cultural contexts of disease. Chapter 24 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9781315543420.ch24
    Keywords: Abigail Woods ; Akihito Suzuki ; Alannah Tomkins ; Arthur W. Frank ; Brian Hurwitz ; Catherine Rider ; Christoph Gradmann ; contagion ; David Cantor ; David M. Turner ; Dominik Wujastyk ; disability ; Elena Carrera ; Elma Brenner ; Fay Bound Alberti ; Genetics ; Havi Carel ; Helen Bynum ; Jana Funke ; Julie Anderson ; Katherine Foxhall ; Katrina Ford ; Leprosy ; Mark Harrison ; Martin D. Moore ; Michael Worboys ; Mnica García ; Pandemic ; plague ; Richard A. McKay ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
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  • 21
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    Papers of the Conference on Genetics of Aging and Longevity 2012 (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: The 2nd International Conference "Genetics of aging and longevity" took place 22-25 April, 2012 in the main building of Russian Academy of Sciences, Moscow, Russia. Top gerontologists and geneticists from 25 countries around the world discussed the current problems in many areas related to the genetics of longevity and mechanisms of aging. This Research Topic is aimed to provide a collection of articles based on the talks, reports and experimental outcomes related to the topics of the conference: "Epigenetic Changes Associated with Longevity", "Hormones and Aging", "Proximal and Cellular Mechanisms of Aging", "Nutrient Signaling, Stress Resistance and Longevity", "Identifying Longevity Genes by Mutational, QTL and Association Mapping", "Fundamental Biological Processes Central to Aging", "Interventions to Extend Lifespan and Promote Healthy Aging", "Longevity: Meta-Analysis and Informatics Approaches". Participants of the Conference submitted 20 papers belonging to Original Research Papers, Review Articles (Including Mini Reviews), Opinion and Perspective Papers. All of the submitted manuscripts were peer-reviewed by excellent Frontiers Review Editors and prepared for publication by highly efficient Frontiers team, and it is a pleasure to thank them all for their work and dedication.
    Keywords: QH426-470 ; Q1-390 ; Aging ; Genetics ; geroprotectors ; evolution ; epigenetics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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    Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to Overcome (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017
    Keywords: QR1-502 ; Q1-390 ; Microbiology ; antimicrobial resistance ; Antibiotic surveillance ; Proteomics ; Genetics ; Infections ; Animal pathogens ; antibiotics ; Epidemiology ; One Health ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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    Ups and downs in western Crete (Hellenic subduction zone) (2014)
    Nature Publishing Group
    Details
    Publication Date: 2017-04-04
    Description: Studies of past sea-level markers are commonly used to unveil the tectonic history and seismic behavior of subduction zones. We present new evidence on vertical motions of the Hellenic subduction zone as resulting from a suite of Late Pleistocene - Holocene shorelines in western Crete (Greece). Shoreline ages obtained by AMS radiocarbon dating of seashells, together with the reappraisal of shoreline ages from previous works, testify a long-term uplift rate of 2.5-2.7 mm/y. This average value, however, includes periods in which the vertical motions vary significantly: 2.6-3.2 mm/y subsidence rate from 42 ka to 23 ka, followed by ~7.7 mm/y sustained uplift rate from 23 ka to present. The last ~5 ky shows a relatively slower uplift rate of 3.0-3.3 mm/y, yet slightly higher than the long-term average. A preliminary tectonic model attempts at explaining these up and down motions by across-strike partitioning of fault activity in the subduction zone.
    Description: Published
    Description: 5677
    Description: 2T. Tettonica attiva
    Description: JCR Journal
    Description: restricted
    Keywords: coastal geomorphology ; tectonic rates ; paleoshorelines ; subduction ; Crete ; 04. Solid Earth::04.04. Geology::04.04.03. Geomorphology ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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    First biological measurements of deep-sea corals from the Red Sea (2013)
    Nature Publishing Group
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 3 (2013): 2802, doi:10.1038/srep02802.
    Description: It is usually assumed that metabolic constraints restrict deep-sea corals to cold-water habitats, with ‘deep-sea’ and ‘cold-water’ corals often used as synonymous. Here we report on the first measurements of biological characters of deep-sea corals from the central Red Sea, where they occur at temperatures exceeding 20°C in highly oligotrophic and oxygen-limited waters. Low respiration rates, low calcification rates, and minimized tissue cover indicate that a reduced metabolism is one of the key adaptations to prevailing environmental conditions. We investigated four sites and encountered six species of which at least two appear to be undescribed. One species is previously reported from the Red Sea but occurs in deep cold waters outside the Red Sea raising interesting questions about presumed environmental constraints for other deep-sea corals. Our findings suggest that the present understanding of deep-sea coral persistence and resilience needs to be revisited.
    Keywords: Ecosystem ecology ; Biodiversity ; Genetics ; Metabolism
    Repository Name: Woods Hole Open Access Server
    Type: Article
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    Format: application/msword
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    The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin (2016)
    Nature Publishing Group
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 6 (2016): 21728, doi:10.1038/srep21728
    Description: Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.
    Description: This research was supported by NSF Awards: OCE-1519578, OCE-1356708, BCS-1118340.
    Keywords: Climate-change impacts ; Forest ecology ; Ocean sciences ; Palaeoclimate
    Repository Name: Woods Hole Open Access Server
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    Production of two highly abundant 2-methyl-branched fatty acids by blooms of the globally significant marine cyanobacteria Trichodesmium erythraeum (2021)
    American Chemical Society
    Details
    Publication Date: 2022-05-27
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Gosselin, K. M., Nelson, R. K., Spivak, A. C., Sylva, S. P., Van Mooy, B. A. S., Aeppli, C., Sharpless, C. M., O’Neil, G. W., Arrington, E. C., Reddy, C. M., & Valentine, D. L. Production of two highly abundant 2-methyl-branched fatty acids by blooms of the globally significant marine cyanobacteria Trichodesmium erythraeum. ACS Omega, 6(35), (2021): 22803–22810, https://doi.org/10.1021/acsomega.1c03196.
    Description: The bloom-forming cyanobacteria Trichodesmium contribute up to 30% to the total fixed nitrogen in the global oceans and thereby drive substantial productivity. On an expedition in the Gulf of Mexico, we observed and sampled surface slicks, some of which included dense blooms of Trichodesmium erythraeum. These bloom samples contained abundant and atypical free fatty acids, identified here as 2-methyldecanoic acid and 2-methyldodecanoic acid. The high abundance and unusual branching pattern of these compounds suggest that they may play a specific role in this globally important organism.
    Description: This work was funded with grants from the National Science Foundation grants OCE-1333148, OCE-1333162, and OCE-1756254 and the Woods Hole Oceanographic Institution (IR&D). GCxGC analysis made possible by WHOI’s Investment in Science Fund.
    Keywords: Lipids ; Alkyls ; Bacteria ; Genetics ; Chromatography
    Repository Name: Woods Hole Open Access Server
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    CO2 and fire influence tropical ecosystem stability in response to climate change (2016)
    Nature Publishing Group
    Details
    Publication Date: 2022-05-26
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 6 (2016): 29587, doi:10.1038/srep29587.
    Description: Interactions between climate, fire and CO2 are believed to play a crucial role in controlling the distributions of tropical woodlands and savannas, but our understanding of these processes is limited by the paucity of data from undisturbed tropical ecosystems. Here we use a 28,000-year integrated record of vegetation, climate and fire from West Africa to examine the role of these interactions on tropical ecosystem stability. We find that increased aridity between 28–15 kyr B.P. led to the widespread expansion of tropical grasslands, but that frequent fires and low CO2 played a crucial role in stabilizing these ecosystems, even as humidity changed. This resulted in an unstable ecosystem state, which transitioned abruptly from grassland to woodlands as gradual changes in CO2 and fire shifted the balance in favor of woody plants. Since then, high atmospheric CO2 has stabilized tropical forests by promoting woody plant growth, despite increased aridity. Our results indicate that the interactions between climate, CO2 and fire can make tropical ecosystems more resilient to change, but that these systems are dynamically unstable and potentially susceptible to abrupt shifts between woodland and grassland dominated states in the future.
    Description: This work was supported by NSF grants EAR0601998, EAR0602355, AGS0402010, ATM0401908, ATM0214525, ATM0096232 and AGS1243125 and a Chevron Centennial Fellowship at the University of Texas at Austin awarded to T.M.S.
    Keywords: Climate-change ecology ; Palaeoclimate
    Repository Name: Woods Hole Open Access Server
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