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  • Mice  (5,503)
  • Mutation  (2,975)
  • Cells, Cultured  (1,353)
  • American Association for the Advancement of Science (AAAS)  (8,384)
  • Springer  (206)
Collection
Keywords
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  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms of tetracycline and rifampicin resistance inBacteroides fragilis mutants obtained by ionizing radiation (1988)
    Springer
    Journal of industrial microbiology and biotechnology 3 (1988), S. 299-304 
    Details
    ISSN: 1476-5535
    Keywords: Anaerobe ; Antibiotic resistance ; Irradiation ; Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Based on a dose-survival curve, a radiation dose of 3.99 C/kg was used to induce antibiotic-resistant mutants inBacteroides fragilis. Escherichia coli B/r membrane fragments were employed as a reducing agent. Antibiotic-resistant mutants ofB. fragilis were utilized to study the mechanism by which these organisms become resistant to selected chemotherapeutic agents. Decreased accumulation of tetracycline by resistant mutants ofB. fragilis suggests that the resistance to this antibiotic is associated with the outer membrane permeability. There is a marked difference in the inhibitory action of rifampicin on RNA polymerase activity in rifampicin-sensitive and-resistant strains ofB. fragilis. This enzyme is, therefore, the likely target for inhibition of bacterial growth in this anaerobe by rifampicin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569530
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  • 2
    Electronic Resource
    Electronic Resource
    Beijerinckia indica var.penicillanicum penicillin V acylase: enhanced enzyme production by catabolite repression-resistant mutant and effect of solvents on enzyme activity (1991)
    Springer
    Journal of industrial microbiology and biotechnology 7 (1991), S. 209-214 
    Details
    ISSN: 1476-5535
    Keywords: Penicillin V acylase ; Beijerinckia indica var.penicillanicum ; Mutation ; Solvent effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Beijerinckia indica var.penicillanicum mutant UREMS-5, producing 168% more penicillin V acylase, was obtained by successive treatment with UV, γ-irradiation and ethylmethane sulfonate. Penicillin V acylase production by the mutant strain was resistant to catabolite repression by glucose. Incorporation of glucose, sodium glutamate and vegetable oils in the medium enhanced enzyme production. The maximum specific production of penicillin V acylase was 244 IU/g dry weight of cells. Effect of solvents on hydrolysis of penicillin V by soluble penicillin V acylase and whole cells was studied. Methylene chloride, chloroform and carbon tetrachloride significantly stimulated the rate of penicillin V hydrolysis by whole cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575885
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  • 3
    Electronic Resource
    Electronic Resource
    Use of continuous-flow UV-induced mutation technique to enhance chlorinated organic biodegradation (1991)
    Springer
    Journal of industrial microbiology and biotechnology 8 (1991), S. 99-106 
    Details
    ISSN: 1476-5535
    Keywords: Mutation ; UV ; Biodegradation ; Chlorinated organic compound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary In this study, a continuous-flow UV-induced mutation (CUM) device and the CUM device coupled to a selector (CUMS) reactor were fabricated and tested for their ability to enhance the probability of obtaining populations capable of chlorinated organic biodegradation. A mixed culture of bacteria were used as the starting strain for both the CUM and CUMS processes. Populations were obtained from the CUM and CUMS systems capable of 4-chlorobenzoic acid, 2,4-dichlorobenzoic acid and chlorendic acid biodegradation. Non-UV irradiated population served as controls for the experiments and did not demonstrate chlorinated organic biodegradation over the test duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578760
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  • 4
    Electronic Resource
    Electronic Resource
    Circling behavior induced by phencyclidine in mice and its inhibition by naloxone (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 73-74 
    Details
    ISSN: 1420-9071
    Keywords: Mice ; circling behavior ; phencyclidine ; naloxone ; hyperactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Phencyclidine (PCP), when given to mice, induces general hyperactivity and rapid circling, similar to that caused by morphine. These effects are partially antagonized by naloxone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02005882
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  • 5
    Electronic Resource
    Electronic Resource
    Antagonistic effect of progesterone towards estradiol dipropionate-induced changes in glycogen content in uterus and vagina of P-mice (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1455-1456 
    Details
    ISSN: 1420-9071
    Keywords: Mice ; uterus ; vagina ; sex steroids ; glycogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Estradiol dipropionate induces an increase (3-fold) in the uterine glycogen content and a decrease (4-fold) in the vaginal glycogen content of Parkes (P) mice. Progesterone antagonizes this estradiol dipropionate-induced response in both the uterine and vaginal tissue. The degree of this antagonism is more pronounced in the uterus than in the vagina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01950032
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  • 6
    Electronic Resource
    Electronic Resource
    Incorporation of32P into renal phospholipids of mice during postnatal growth (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1184-1186 
    Details
    ISSN: 1420-9071
    Keywords: Mice ; phospholipids ; kidney growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary During the first 40 days of life the rate of incorporation of32P into total phospholipids and into phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, diphosphatidylglycerol, phosphatidic acid and phosphatidylinositol of mouse kidney was by some 25–35% higher than in older animals. Results suggest a different involvement of cellular membranes during of normal and compensatory renal growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951720
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  • 7
    Electronic Resource
    Electronic Resource
    Growth ofZymomonas on lactose: Gene cloning in combination with mutagenesis (1989)
    Springer
    Journal of industrial microbiology and biotechnology 4 (1989), S. 19-27 
    Details
    ISSN: 1476-5535
    Keywords: Zymomonas mobilis ; Growth on lactose ; Cloning ; Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Wild-type strains ofZymomonas mobilis have a limited substrate range of glucose, fructose and sucrose. In order to expand this substrate range, transconjugants ofZ. mobilis containing Lac+ plasmids have been constructed. Although β-galactosidase is expressed in such strains, they lack the ability to grow on lactose. We now report the development ofZ. mobilis strains capable of growth on lactose. This was achieved in two stages. First, a broad host range plasmid was constructed (pRUT102) which contained the lactose operon under the control of aZ. mobilis promoter plus genes for galactose utilization.Z. mobilis CP4.45 containing pRUT102 was then subjected to mutagenesis combined with continued selection pressure for growth on lactose. One strain,Z. mobilis SB6, produced a turbid culture that yielded 0.25% ethanol from 5% lactose (plus 2% yeast extract) in 15 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569689
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison of symbiotic effectiveness of Rhizobium sp. with positive hydrogen-uptake activity compared with negative mutants in relation to nitrogen fixation in mungbean (Vigna radiata L.) (1995)
    Springer
    Biology and fertility of soils 20 (1995), S. 270-274 
    Details
    ISSN: 1432-0789
    Keywords: Mungbean ; Vigna radiata ; Nitrogen fixation ; Hydrogen uptake ; Mutation ; Nitrosoguanidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract H2 uptake activity was well distributed in Rhizobium sp. strains isolated from nodules of mung-bean (Vigna radiata L.). Two effective strains, RMP1 und RMP2, exhibiting significantly higher H2 uptake activity were subjected to mutagenesis with nitrosoguanidine. The respective mutation frequencies were 0.18 and 0.19%. Three Hup- mutants each of RMP1 und RMP2 were compared with the wild-type parent strains under pot culture experiments to evaluate the significance of the H2 uptake system in biological N2 fixation. Nodulation capabilities, plant growth characteristics, and the chlorophyll content of the leaves were significantly reduced in the plants treated with Hup- mutants. Nitrogenase activity in Hup- nodules was reduced by 8–41%. Similarly, N accumulation was also reduced singificantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336089
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  • 9
    Electronic Resource
    Electronic Resource
    Mutational analysis of the upstream activation site of yeast ribosomal protein genes (1989)
    Springer
    Current genetics 15 (1989), S. 247-251 
    Details
    ISSN: 1432-0983
    Keywords: Yeast ; Ribosomal protein gene ; Transcription activation ; Mutation ; Methylation interference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Most ribosomal protein (rp-)genes in yeast are preceded by conserved sequence motifs that act as upstream transcription-activating sites (RPG box). These sequence elements have previously been shown to represent specific binding sites for a protein factor, TUF. Comparison of the various nucleotide elements identified so far indicates a remarkably high degree of variation in the respective sequences. On the other hand, a methylation interference study performed with one RPG box revealed close contact points with the TUF protein along the entire sequence. To investigate the sequence requirements of the RPG box, we inserted synthetic oligonucleotides that differed from the general consensus sequence ACACCCATACATTT at single positions into a deletion mutant of the L25 promoter that lacked its natural RPG elements. Transcription activity was estimated by Northern analyses of the cellular level of L25-galK hybrid transcripts. The results show that in the 3′ part of this sequence element single substitutions are allowed at all positions, in the 5′ part, however, the nucleotide requirements appear to be more stringent. In particular, the invariant C at position 5 of the consensus sequence is absolutely necessary for its enhancer function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447039
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  • 10
    Electronic Resource
    Electronic Resource
    Generation of new functional mutant alleles by premeiotic disruption of the Neurospora crassa am gene (1990)
    Springer
    Current genetics 18 (1990), S. 441-445 
    Details
    ISSN: 1432-0983
    Keywords: Neurospora crassa ; Mutation ; RIP phenomenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In the further analysis of a cross in which the mis-sense allele, am 3, of the Neurospora crassa am (glutamate dehydrogenase) gene was present in one parent together with two ectopic wild-type gene copies, one ascus was identified in which the two ectopic copies had been inactivated by the RIP process whereas the am 3 allele continued to produce its characteristic enzyme variety in active, but heat-sensitive, form. The am 3 allele had also acquired a new HindIII restriction site. It had no detectable methylation. The mutations responsible respectively for the new restriction site and the modified enzyme properties were separated from each other, and from the original am 3 mutation, by selecting for intragenic recombination on either side of the am 3 site. In this way two new effectively wild-type alleles were generated, one characterised by its heat-sensitive and kinetically modified enzyme product and the other by a new HindIII site. These results demonstrate that the RIP phenomenon can be a source of new functional alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309914
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