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  • Biochemistry
  • Life and Medical Sciences
  • American Association for the Advancement of Science (AAAS)  (157)
  • De Gruyter  (1)
  • 1
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    Biochemistry Laboratory Manual For Undergraduates. An Inquiry-Based Approach (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-05
    Description: Biochemistry laboratory manual for undergraduates – an inquiry based approach by Gerczei and Pattison is the first textbook on the market that uses a highly relevant model, antibiotic resistance, to teach seminal topics of biochemistry and molecular biology while incorporating the blossoming field of bioinformatics. The novelty of this manual is the incorporation of a student-driven real real-life research project into the undergraduate curriculum. Since students test their own mutant design, even the most experienced students remain engaged with the process, while the less experienced ones get their first taste of biochemistry research. Inclusion of a research project does not entail a limitation: this manual includes all classic biochemistry techniques such as HPLC or enzyme kinetics and is complete with numerous problem sets relating to each topic.
    Keywords: QD415-436 ; Molecular Biology ; Biochemistry ; Laboratory Manual ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
    Language: English
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    E-BOOK
  • 2
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    [This Week in Science] Adaptors conduct the EGFR symphony (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-15
    Description: Author: Leslie K. Ferrarelli
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    [This Week in Science] Making error-free DNA from RNA (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-24
    Description: Author: Guy Riddihough
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    [Perspective] A metal shuttle keeps pathogens well fed (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-05-27
    Description: Staphylococcus aureus is a Gram-positive bacterium that is a leading cause of life-threatening infections in humans. Knowledge of how this pathogen colonizes the human host and causes disease is crucial for the development of strategies to prevent and treat S. aureus infections (see the image, next page). On page 1105 of this issue, Ghssein et al. report the discovery, isolation, and functional evaluation of staphylopine (see the figure), a compound biosynthesized by S. aureus that captures metal ions from the pathogen's surroundings and thereby enables it to grow (1). Author: Elizabeth M. Nolan
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    [This Week in Science] The fuel for fungal enzymes (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-05-27
    Description: Author: Nicolas S. Wigginton
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    [This Week in Science] A nuclear power source in the cell (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-03
    Description: Author: Guy Riddihough
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Breakthrough of the year. Peering into 2002 (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2001 Dec 21;294(5551):2444.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752539" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomical Phenomena ; Astronomy ; Biochemical Phenomena ; Biochemistry ; Computer Simulation ; Embryo, Mammalian/cytology ; Genetics, Medical ; Humans ; Microscopy, Electron ; Optics and Photonics ; Proteins/physiology ; Proteome ; *Research ; *Science ; Stem Cells
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Molecular biology. Creation's seventh day (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-05
    Description: Scientists at the Scripps Research Institute are attempting to find out what life would look like if DNA contained more than four nucleotide bases and proteins more than 20 amino acids. By reengineering DNA, RNA, and the proteins that interact with them, they hope to create synthetic organisms with a chemical makeup fundamentally different from all life that has existed on Earth for the last 3.8 billion years. If they succeed, their biochemical reengineering could have a profound effect on everything from basic molecular biology to industrial chemistry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):232-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10917842" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/chemistry ; Biochemical Phenomena ; Biochemistry ; Bioethics ; *Biology ; DNA/*chemistry ; Genetic Code ; Genetic Engineering ; Life ; Proteins/chemical synthesis/*chemistry/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Free-electron lasers. Status and applications (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-09
    Description: A free-electron laser consists of an electron beam propagating through a periodic magnetic field. Today such lasers are used for research in materials science, chemical technology, biophysical science, medical applications, surface studies, and solid-state physics. Free-electron lasers with higher average power and shorter wavelengths are under development. Future applications range from industrial processing of materials to light sources for soft and hard x-rays.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Shea, P G -- Freund, H P -- New York, N.Y. -- Science. 2001 Jun 8;292(5523):1853-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Electrical and Computer Engineering and Institute for Plasma Research, University of Maryland, College Park, MD 20742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11397938" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Biological Science Disciplines ; Electromagnetic Fields ; Electrons ; Laser Therapy ; *Lasers ; Physical Phenomena ; Physics ; *Research
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Evolution of a highly active and enantiospecific metalloenzyme from short peptides (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-12-14
    Description: Primordial sequence signatures in modern proteins imply ancestral origins tracing back to simple peptides. Although short peptides seldom adopt unique folds, metal ions might have templated their assembly into higher-order structures in early evolution and imparted useful chemical reactivity. Recapitulating such a biogenetic scenario, we have combined design and laboratory evolution to transform a zinc-binding peptide into a globular enzyme capable of accelerating ester cleavage with exacting enantiospecificity and high catalytic efficiency ( k cat / K M ~ 10 6 M –1 s –1 ). The simultaneous optimization of structure and function in a naïve peptide scaffold not only illustrates a plausible enzyme evolutionary pathway from the distant past to the present but also proffers exciting future opportunities for enzyme design and engineering.
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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