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  • Elasticity
  • Fracture
  • American Association for the Advancement of Science (AAAS)  (59)
  • Nature Publishing Group (NPG)  (13)
  • Am. Soc. Mech. Eng.
  • Institute of Physics
  • 1
    Publication Date: 2016-04-23
    Description: The microtubule (MT) cytoskeleton can transmit mechanical signals and resist compression in contracting cardiomyocytes. How MTs perform these roles remains unclear because of difficulties in observing MTs during the rapid contractile cycle. Here, we used high spatial and temporal resolution imaging to characterize MT behavior in beating mouse myocytes. MTs deformed under contractile load into sinusoidal buckles, a behavior dependent on posttranslational "detyrosination" of alpha-tubulin. Detyrosinated MTs associated with desmin at force-generating sarcomeres. When detyrosination was reduced, MTs uncoupled from sarcomeres and buckled less during contraction, which allowed sarcomeres to shorten and stretch with less resistance. Conversely, increased detyrosination promoted MT buckling, stiffened the myocyte, and correlated with impaired function in cardiomyopathy. Thus, detyrosinated MTs represent tunable, compression-resistant elements that may impair cardiac function in disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robison, Patrick -- Caporizzo, Matthew A -- Ahmadzadeh, Hossein -- Bogush, Alexey I -- Chen, Christina Yingxian -- Margulies, Kenneth B -- Shenoy, Vivek B -- Prosser, Benjamin L -- HL089847/HL/NHLBI NIH HHS/ -- HL105993/HL/NHLBI NIH HHS/ -- R00-HL114879/HL/NHLBI NIH HHS/ -- R01EB017753/EB/NIBIB NIH HHS/ -- T32AR053461-09/AR/NIAMS NIH HHS/ -- T32HL007954/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2016 Apr 22;352(6284):aaf0659. doi: 10.1126/science.aaf0659.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. ; Department of Materials Science and Engineering, University of Pennsylvania School of Engineering and Applied Science, Philadelphia, PA 19104, USA. ; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. ; Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. bpros@mail.med.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27102488" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Desmin/metabolism ; Elasticity ; Heart Failure/metabolism/physiopathology ; Humans ; Male ; Mice ; Microtubules/*metabolism ; Models, Biological ; *Myocardial Contraction ; Myocytes, Cardiac/metabolism/*physiology ; Peptide Synthases/genetics/metabolism ; *Protein Processing, Post-Translational ; RNA, Small Interfering/genetics ; Rats ; Rats, Sprague-Dawley ; Sarcomeres/metabolism ; Tubulin/*metabolism ; Tyrosine/*metabolism
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  • 2
    Publication Date: 2015-07-25
    Description: Superelastic conducting fibers with improved properties and functionalities are needed for diverse applications. Here we report the fabrication of highly stretchable (up to 1320%) sheath-core conducting fibers created by wrapping carbon nanotube sheets oriented in the fiber direction on stretched rubber fiber cores. The resulting structure exhibited distinct short- and long-period sheath buckling that occurred reversibly out of phase in the axial and belt directions, enabling a resistance change of less than 5% for a 1000% stretch. By including other rubber and carbon nanotube sheath layers, we demonstrated strain sensors generating an 860% capacitance change and electrically powered torsional muscles operating reversibly by a coupled tension-to-torsion actuation mechanism. Using theory, we quantitatively explain the complementary effects of an increase in muscle length and a large positive Poisson's ratio on torsional actuation and electronic properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Z F -- Fang, S -- Moura, F A -- Ding, J N -- Jiang, N -- Di, J -- Zhang, M -- Lepro, X -- Galvao, D S -- Haines, C S -- Yuan, N Y -- Yin, S G -- Lee, D W -- Wang, R -- Wang, H Y -- Lv, W -- Dong, C -- Zhang, R C -- Chen, M J -- Yin, Q -- Chong, Y T -- Zhang, R -- Wang, X -- Lima, M D -- Ovalle-Robles, R -- Qian, D -- Lu, H -- Baughman, R H -- New York, N.Y. -- Science. 2015 Jul 24;349(6246):400-4. doi: 10.1126/science.aaa7952.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, TX 75080, USA. Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China. Jiangnan Graphene Research Institute, Changzhou 213149, China. ; Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, TX 75080, USA. Jiangnan Graphene Research Institute, Changzhou 213149, China. ; Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, TX 75080, USA. Applied Physics Department, State University of Campinas, Campinas, SP 13081-970, Brazil. ; Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China. Micro/Nano Science and Technology Center, Jiangsu University, Zhenjiang 212013, China. ; Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, TX 75080, USA. ; High-Performance Materials Institute, Florida State University, Tallahassee, FL 32310, USA. ; Applied Physics Department, State University of Campinas, Campinas, SP 13081-970, Brazil. ; Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China. Jiangnan Graphene Research Institute, Changzhou 213149, China. ; Jiangnan Graphene Research Institute, Changzhou 213149, China. Institute of Materials Physics, Tianjin University of Technology, Tianjin 300384, China. ; Jiangnan Graphene Research Institute, Changzhou 213149, China. ; School of Astronautics, Northwestern Polytechnical University, Xi'an 710072, China. Department of Mechanical Engineering, University of Texas at Dallas, Richardson, TX 75080, USA. ; Department of Mechanical Engineering, University of Texas at Dallas, Richardson, TX 75080, USA. ; Lintec of America, Nano-Science and Technology Center, Richardson, TX 75081, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26206929" target="_blank"〉PubMed〈/a〉
    Keywords: *Elastic Tissue ; Elasticity ; Electric Capacitance ; *Electronics ; *Muscle, Skeletal ; *Nanotubes, Carbon ; Torsion, Mechanical
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  • 3
    Publication Date: 2015-01-13
    Description: The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minev, Ivan R -- Musienko, Pavel -- Hirsch, Arthur -- Barraud, Quentin -- Wenger, Nikolaus -- Moraud, Eduardo Martin -- Gandar, Jerome -- Capogrosso, Marco -- Milekovic, Tomislav -- Asboth, Leonie -- Torres, Rafael Fajardo -- Vachicouras, Nicolas -- Liu, Qihan -- Pavlova, Natalia -- Duis, Simone -- Larmagnac, Alexandre -- Voros, Janos -- Micera, Silvestro -- Suo, Zhigang -- Courtine, Gregoire -- Lacour, Stephanie P -- New York, N.Y. -- Science. 2015 Jan 9;347(6218):159-63. doi: 10.1126/science.1260318.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronic Interfaces, Centre for Neuroprosthetics, Institute of Microengineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland. ; International Paraplegic Foundation Chair in Spinal Cord Repair, Centre for Neuroprosthetics and Brain Mind Institute, EPFL, Switzerland. Pavlov Institute of Physiology, St. Petersburg, Russia. ; International Paraplegic Foundation Chair in Spinal Cord Repair, Centre for Neuroprosthetics and Brain Mind Institute, EPFL, Switzerland. ; Translational Neural Engineering Laboratory, Center for Neuroprosthetics and Institute of Bioengineering, EPFL, Lausanne, Switzerland. ; Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronic Interfaces, Centre for Neuroprosthetics, Institute of Microengineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland. International Paraplegic Foundation Chair in Spinal Cord Repair, Centre for Neuroprosthetics and Brain Mind Institute, EPFL, Switzerland. ; School of Engineering and Applied Sciences, Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA, USA. ; Laboratory for Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Switzerland. ; Translational Neural Engineering Laboratory, Center for Neuroprosthetics and Institute of Bioengineering, EPFL, Lausanne, Switzerland. The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa 56025, Italy. ; International Paraplegic Foundation Chair in Spinal Cord Repair, Centre for Neuroprosthetics and Brain Mind Institute, EPFL, Switzerland. gregoire.courtine@epfl.ch stephanie.lacour@epfl.ch. ; Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronic Interfaces, Centre for Neuroprosthetics, Institute of Microengineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland. gregoire.courtine@epfl.ch stephanie.lacour@epfl.ch.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25574019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biocompatible Materials/therapeutic use ; Brain-Computer Interfaces ; Drug Delivery Systems/*methods ; *Dura Mater ; Elasticity ; Electric Stimulation/*methods ; Electrochemotherapy/*methods ; *Electrodes, Implanted ; Locomotion ; Mice ; Mice, Inbred Strains ; Motor Cortex/physiopathology ; Multimodal Imaging ; Neurons/physiology ; Paralysis/etiology/physiopathology/*therapy ; Platinum ; *Prostheses and Implants ; Silicon ; Spinal Cord/physiopathology ; Spinal Cord Injuries/complications/physiopathology/*therapy
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  • 4
    Publication Date: 2014-05-16
    Description: Groundwater use in California's San Joaquin Valley exceeds replenishment of the aquifer, leading to substantial diminution of this resource and rapid subsidence of the valley floor. The volume of groundwater lost over the past century and a half also represents a substantial reduction in mass and a large-scale unburdening of the lithosphere, with significant but unexplored potential impacts on crustal deformation and seismicity. Here we use vertical global positioning system measurements to show that a broad zone of rock uplift of up to 1-3 mm per year surrounds the southern San Joaquin Valley. The observed uplift matches well with predicted flexure from a simple elastic model of current rates of water-storage loss, most of which is caused by groundwater depletion. The height of the adjacent central Coast Ranges and the Sierra Nevada is strongly seasonal and peaks during the dry late summer and autumn, out of phase with uplift of the valley floor during wetter months. Our results suggest that long-term and late-summer flexural uplift of the Coast Ranges reduce the effective normal stress resolved on the San Andreas Fault. This process brings the fault closer to failure, thereby providing a viable mechanism for observed seasonality in microseismicity at Parkfield and potentially affecting long-term seismicity rates for fault systems adjacent to the valley. We also infer that the observed contemporary uplift of the southern Sierra Nevada previously attributed to tectonic or mantle-derived forces is partly a consequence of human-caused groundwater depletion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amos, Colin B -- Audet, Pascal -- Hammond, William C -- Burgmann, Roland -- Johanson, Ingrid A -- Blewitt, Geoffrey -- England -- Nature. 2014 May 22;509(7501):483-6. doi: 10.1038/nature13275. Epub 2014 May 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geology Department, Western Washington University, Bellingham, Washington 98225-9080, USA. ; Department of Earth Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. ; Nevada Geodetic Laboratory, Nevada Bureau of Mines and Geology and Nevada Seismological Laboratory, University of Nevada, Reno, Nevada 89557, USA. ; 1] Berkeley Seismological Laboratory, University of California, Berkeley, California 94720-4760, USA [2] Department of Earth and Planetary Science, University of California, Berkeley, California 97720-4767, USA. ; Berkeley Seismological Laboratory, University of California, Berkeley, California 94720-4760, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24828048" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; California ; Earthquakes/*statistics & numerical data ; Elasticity ; Environmental Monitoring ; Geographic Information Systems ; Groundwater/*analysis ; *Models, Theoretical ; Seasons ; Water Supply/analysis/*statistics & numerical data
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  • 5
    Publication Date: 2014-04-05
    Description: When mounted on the skin, modern sensors, circuits, radios, and power supply systems have the potential to provide clinical-quality health monitoring capabilities for continuous use, beyond the confines of traditional hospital or laboratory facilities. The most well-developed component technologies are, however, broadly available only in hard, planar formats. As a result, existing options in system design are unable to effectively accommodate integration with the soft, textured, curvilinear, and time-dynamic surfaces of the skin. Here, we describe experimental and theoretical approaches for using ideas in soft microfluidics, structured adhesive surfaces, and controlled mechanical buckling to achieve ultralow modulus, highly stretchable systems that incorporate assemblies of high-modulus, rigid, state-of-the-art functional elements. The outcome is a thin, conformable device technology that can softly laminate onto the surface of the skin to enable advanced, multifunctional operation for physiological monitoring in a wireless mode.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Sheng -- Zhang, Yihui -- Jia, Lin -- Mathewson, Kyle E -- Jang, Kyung-In -- Kim, Jeonghyun -- Fu, Haoran -- Huang, Xian -- Chava, Pranav -- Wang, Renhan -- Bhole, Sanat -- Wang, Lizhe -- Na, Yoon Joo -- Guan, Yue -- Flavin, Matthew -- Han, Zheshen -- Huang, Yonggang -- Rogers, John A -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):70-4. doi: 10.1126/science.1250169.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700852" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Elasticity ; Electrocardiography/instrumentation/methods ; Electrocardiography, Ambulatory/instrumentation/methods ; Electroencephalography/instrumentation/methods ; Electromyography/instrumentation/methods ; Electrooculography ; Equipment Design ; Humans ; Male ; Microfluidics/*instrumentation ; Monitoring, Ambulatory/*instrumentation/methods ; Monitoring, Physiologic/*instrumentation/methods ; Remote Sensing Technology ; Silicone Elastomers ; *Skin ; Wireless Technology ; Young Adult
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  • 6
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    Nature Publishing Group (NPG)
    Publication Date: 2013-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonietz, Erika -- England -- Nature. 2012 Nov 22;491(7425):S56-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23320288" target="_blank"〉PubMed〈/a〉
    Keywords: Biomechanical Phenomena ; Biophysics/methods ; Cell Communication ; *Cell Physiological Processes ; Drug Resistance, Neoplasm ; Elasticity ; Hardness ; Humans ; Medical Oncology ; *Models, Biological ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms/diagnosis/drug therapy/genetics/*pathology ; Rheology ; Tumor Microenvironment ; Viscosity
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  • 7
    Publication Date: 2012-09-08
    Description: Hydrogels are used as scaffolds for tissue engineering, vehicles for drug delivery, actuators for optics and fluidics, and model extracellular matrices for biological studies. The scope of hydrogel applications, however, is often severely limited by their mechanical behaviour. Most hydrogels do not exhibit high stretchability; for example, an alginate hydrogel ruptures when stretched to about 1.2 times its original length. Some synthetic elastic hydrogels have achieved stretches in the range 10-20, but these values are markedly reduced in samples containing notches. Most hydrogels are brittle, with fracture energies of about 10 J m(-2) (ref. 8), as compared with approximately 1,000 J m(-2) for cartilage and approximately 10,000 J m(-2) for natural rubbers. Intense efforts are devoted to synthesizing hydrogels with improved mechanical properties; certain synthetic gels have reached fracture energies of 100-1,000 J m(-2) (refs 11, 14, 17). Here we report the synthesis of hydrogels from polymers forming ionically and covalently crosslinked networks. Although such gels contain approximately 90% water, they can be stretched beyond 20 times their initial length, and have fracture energies of approximately 9,000 J m(-2). Even for samples containing notches, a stretch of 17 is demonstrated. We attribute the gels' toughness to the synergy of two mechanisms: crack bridging by the network of covalent crosslinks, and hysteresis by unzipping the network of ionic crosslinks. Furthermore, the network of covalent crosslinks preserves the memory of the initial state, so that much of the large deformation is removed on unloading. The unzipped ionic crosslinks cause internal damage, which heals by re-zipping. These gels may serve as model systems to explore mechanisms of deformation and energy dissipation, and expand the scope of hydrogel applications.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642868/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642868/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Jeong-Yun -- Zhao, Xuanhe -- Illeperuma, Widusha R K -- Chaudhuri, Ovijit -- Oh, Kyu Hwan -- Mooney, David J -- Vlassak, Joost J -- Suo, Zhigang -- R01 DE013033/DE/NIDCR NIH HHS/ -- R37 DE013033/DE/NIDCR NIH HHS/ -- England -- Nature. 2012 Sep 6;489(7414):133-6. doi: 10.1038/nature11409.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22955625" target="_blank"〉PubMed〈/a〉
    Keywords: Acrylic Resins/chemistry ; Alginates/chemistry ; Carbohydrate Sequence ; Elasticity ; Glucuronic Acid/chemistry ; Hexuronic Acids/chemistry ; Hydrogels/chemical synthesis/*chemistry ; Materials Testing ; Molecular Sequence Data ; Polymers/chemical synthesis/chemistry
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  • 8
    Publication Date: 2012-03-17
    Description: Various plants and fungi have evolved ingenious devices to disperse their spores. One such mechanism is the cavitation-triggered catapult of fern sporangia. The spherical sporangia enclosing the spores are equipped with a row of 12 to 13 specialized cells, the annulus. When dehydrating, these cells induce a dramatic change of curvature in the sporangium, which is released abruptly after the cavitation of the annulus cells. The entire ejection process is reminiscent of human-made catapults with one notable exception: The sporangia lack the crossbar that arrests the catapult arm in its returning motion. We show that much of the sophistication and efficiency of the ejection mechanism lies in the two very different time scales associated with the annulus closure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noblin, X -- Rojas, N O -- Westbrook, J -- Llorens, C -- Argentina, M -- Dumais, J -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1322. doi: 10.1126/science.1215985.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universite de Nice Sophia Antipolis (UNS), Laboratoire de Physique de la Matiere Condensee, CNRS UMR 7336, Nice, France. xavier.noblin@unice.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22422975" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Shape ; Elasticity ; Polypodium/cytology/*physiology ; Sporangia/cytology/*physiology ; Spores/*physiology ; Water
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  • 9
    Publication Date: 2012-03-03
    Description: Although genetic control of morphogenesis is well established, elaboration of complex shapes requires changes in the mechanical properties of cells. In plants, the first visible sign of leaf formation is a bulge on the flank of the shoot apical meristem. Bulging results from local relaxation of cell walls, which causes them to yield to internal hydrostatic pressure. By manipulation of tissue tension in combination with quantitative live imaging and finite-element modeling, we found that the slow-growing area at the shoot tip is substantially strain-stiffened compared with surrounding fast-growing tissue. We propose that strain stiffening limits growth, restricts organ bulging, and contributes to the meristem's functional zonation. Thus, mechanical signals are not just passive readouts of gene action but feed back on morphogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kierzkowski, Daniel -- Nakayama, Naomi -- Routier-Kierzkowska, Anne-Lise -- Weber, Alain -- Bayer, Emmanuelle -- Schorderet, Martine -- Reinhardt, Didier -- Kuhlemeier, Cris -- Smith, Richard S -- New York, N.Y. -- Science. 2012 Mar 2;335(6072):1096-9. doi: 10.1126/science.1213100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Plant Sciences, University of Bern, Bern, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383847" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Wall/physiology/ultrastructure ; Elasticity ; Hydrostatic Pressure ; Lycopersicon esculentum/cytology/*growth & development ; Meristem/cytology/*growth & development ; Models, Biological ; *Morphogenesis ; Osmolar Concentration ; Osmotic Pressure ; Plant Shoots/cytology/*growth & development
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  • 10
    Publication Date: 2012-02-03
    Description: Natural materials are renowned for exquisite designs that optimize function, as illustrated by the elasticity of blood vessels, the toughness of bone and the protection offered by nacre. Particularly intriguing are spider silks, with studies having explored properties ranging from their protein sequence to the geometry of a web. This material system, highly adapted to meet a spider's many needs, has superior mechanical properties. In spite of much research into the molecular design underpinning the outstanding performance of silk fibres, and into the mechanical characteristics of web-like structures, it remains unknown how the mechanical characteristics of spider silk contribute to the integrity and performance of a spider web. Here we report web deformation experiments and simulations that identify the nonlinear response of silk threads to stress--involving softening at a yield point and substantial stiffening at large strain until failure--as being crucial to localize load-induced deformation and resulting in mechanically robust spider webs. Control simulations confirmed that a nonlinear stress response results in superior resistance to structural defects in the web compared to linear elastic or elastic-plastic (softening) material behaviour. We also show that under distributed loads, such as those exerted by wind, the stiff behaviour of silk under small deformation, before the yield point, is essential in maintaining the web's structural integrity. The superior performance of silk in webs is therefore not due merely to its exceptional ultimate strength and strain, but arises from the nonlinear response of silk threads to strain and their geometrical arrangement in a web.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cranford, Steven W -- Tarakanova, Anna -- Pugno, Nicola M -- Buehler, Markus J -- England -- Nature. 2012 Feb 1;482(7383):72-6. doi: 10.1038/nature10739.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22297972" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Elasticity ; Hardness ; Models, Biological ; Silk/*chemistry ; *Spiders/physiology ; *Tensile Strength ; Wind
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  • 11
    Publication Date: 2011-09-24
    Description: We studied the mechanical process of seed pods opening in Bauhinia variegate and found a chirality-creating mechanism, which turns an initially flat pod valve into a helix. We studied con fi gurations of strips cut from pod valve tissue and from composite elastic materials that mimic its structure. The experiments reveal various helical con fi gurations with sharp morphological transitions between them. Using the mathematical framework of "incompatible elasticity," we modeled the pod as a thin strip with a flat intrinsic metric and a saddle-like intrinsic curvature. Our theoretical analysis quantitatively predicts all observed con fi gurations, thus linking the pod's microscopic structure and macroscopic conformation. We suggest that this type of incompatible strip is likely to play a role in the self-assembly of chiral macromolecules and could be used for the engineering of synthetic self-shaping devices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armon, Shahaf -- Efrati, Efi -- Kupferman, Raz -- Sharon, Eran -- New York, N.Y. -- Science. 2011 Sep 23;333(6050):1726-30. doi: 10.1126/science.1203874.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Racah Institute of Physics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940888" target="_blank"〉PubMed〈/a〉
    Keywords: Bauhinia/*anatomy & histology/physiology ; Biomimetic Materials ; Elasticity ; *Latex ; Mathematical Concepts ; Models, Biological ; Physical Phenomena ; Seeds/*anatomy & histology/*physiology
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forterre, Yoel -- Dumais, Jacques -- New York, N.Y. -- Science. 2011 Sep 23;333(6050):1715-6. doi: 10.1126/science.1210734.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IUSTI, CNRS, Aix-Marseille Universite, 13453 Marseille Cedex 13, France. yoel.forterre@polytech.univ-mrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940886" target="_blank"〉PubMed〈/a〉
    Keywords: Bauhinia/*anatomy & histology ; Biomimetic Materials ; Elasticity ; Seeds/*anatomy & histology
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  • 13
    Publication Date: 2011-08-05
    Description: The developing vertebrate gut tube forms a reproducible looped pattern as it grows into the body cavity. Here we use developmental experiments to eliminate alternative models and show that gut looping morphogenesis is driven by the homogeneous and isotropic forces that arise from the relative growth between the gut tube and the anchoring dorsal mesenteric sheet, tissues that grow at different rates. A simple physical mimic, using a differentially strained composite of a pliable rubber tube and a soft latex sheet is consistent with this mechanism and produces similar patterns. We devise a mathematical theory and a computational model for the number, size and shape of intestinal loops based solely on the measurable geometry, elasticity and relative growth of the tissues. The predictions of our theory are quantitatively consistent with observations of intestinal loops at different stages of development in the chick embryo. Our model also accounts for the qualitative and quantitative variation in the distinct gut looping patterns seen in a variety of species including quail, finch and mouse, illuminating how the simple macroscopic mechanics of differential growth drives the morphology of the developing gut.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335276/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335276/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savin, Thierry -- Kurpios, Natasza A -- Shyer, Amy E -- Florescu, Patricia -- Liang, Haiyi -- Mahadevan, L -- Tabin, Clifford J -- R01 HD047360/HD/NICHD NIH HHS/ -- R01 HD047360-07/HD/NICHD NIH HHS/ -- England -- Nature. 2011 Aug 3;476(7358):57-62. doi: 10.1038/nature10277.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21814276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Chick Embryo ; Computer Simulation ; Elasticity ; Female ; Finches/embryology ; Intestines/*anatomy & histology/*embryology ; Mesentery/anatomy & histology/embryology ; Mice ; *Models, Anatomic ; *Models, Biological ; Quail/embryology ; Rotation ; Rubber
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  • 14
    Publication Date: 2011-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huck, Wilhelm T S -- England -- Nature. 2011 Apr 28;472(7344):425-6. doi: 10.1038/472425a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21525922" target="_blank"〉PubMed〈/a〉
    Keywords: Biosensing Techniques ; Drug Delivery Systems ; Elasticity ; Elastomers/chemistry ; Molecular Conformation/radiation effects ; Pliability ; Polymers/*chemistry/*radiation effects ; Tissue Engineering
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  • 15
    Publication Date: 2011-03-18
    Description: Inelastic light scattering spectroscopy has, since its first discovery, been an indispensable tool in physical science for probing elementary excitations, such as phonons, magnons and plasmons in both bulk and nanoscale materials. In the quantum mechanical picture of inelastic light scattering, incident photons first excite a set of intermediate electronic states, which then generate crystal elementary excitations and radiate energy-shifted photons. The intermediate electronic excitations therefore have a crucial role as quantum pathways in inelastic light scattering, and this is exemplified by resonant Raman scattering and Raman interference. The ability to control these excitation pathways can open up new opportunities to probe, manipulate and utilize inelastic light scattering. Here we achieve excitation pathway control in graphene with electrostatic doping. Our study reveals quantum interference between different Raman pathways in graphene: when some of the pathways are blocked, the one-phonon Raman intensity does not diminish, as commonly expected, but increases dramatically. This discovery sheds new light on the understanding of resonance Raman scattering in graphene. In addition, we demonstrate hot-electron luminescence in graphene as the Fermi energy approaches half the laser excitation energy. This hot luminescence, which is another form of inelastic light scattering, results from excited-state relaxation channels that become available only in heavily doped graphene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Chi-Fan -- Park, Cheol-Hwan -- Boudouris, Bryan W -- Horng, Jason -- Geng, Baisong -- Girit, Caglar -- Zettl, Alex -- Crommie, Michael F -- Segalman, Rachel A -- Louie, Steven G -- Wang, Feng -- England -- Nature. 2011 Mar 31;471(7340):617-20. doi: 10.1038/nature09866. Epub 2011 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of California at Berkeley, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21412234" target="_blank"〉PubMed〈/a〉
    Keywords: Elasticity ; Electrons ; Graphite/*chemistry ; *Light ; Luminescence ; Photons ; *Quantum Theory ; *Scattering, Radiation ; Spectrum Analysis, Raman ; Static Electricity
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  • 16
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    Nature Publishing Group (NPG)
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hersen, Pascal -- Ladoux, Benoit -- England -- Nature. 2011 Feb 17;470(7334):340-1. doi: 10.1038/470340a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21331032" target="_blank"〉PubMed〈/a〉
    Keywords: Biomechanical Phenomena ; Cell Adhesion/physiology ; Cell Movement/*physiology ; Dictyostelium/*cytology ; Elasticity ; Single-Cell Analysis/*methods
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2010-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhatia, Mickie -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1024-5. doi: 10.1126/science.1194919.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. mbhatia@mcmaster.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798306" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Culture Techniques/*methods ; Cell Differentiation ; Cell Division ; Cells, Cultured ; Elasticity ; Humans ; Hydrogels ; Mice ; Muscle Fibers, Skeletal/*cytology/physiology ; Myoblasts, Skeletal/cytology/physiology ; Regeneration ; Stem Cell Niche/*physiology ; Stem Cell Transplantation ; Stem Cells/*physiology
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  • 18
    Publication Date: 2010-08-07
    Description: Using optical trapping and fluorescence imaging techniques, we measured the step size and stiffness of single skeletal myosins interacting with actin filaments and arranged on myosin-rod cofilaments that approximate myosin mechanics during muscle contraction. Stiffness is dramatically lower for negatively compared to positively strained myosins, consistent with buckling of myosin's subfragment 2 rod domain. Low stiffness minimizes drag of negatively strained myosins during contraction at loaded conditions. Myosin's elastic portion is stretched during active force generation, reducing apparent step size with increasing load, even though the working stroke is approximately constant at about 8 nanometers. Taking account of the nonlinear nature of myosin elasticity is essential to relate myosin's internal structural changes to physiological force generation and filament sliding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaya, Motoshi -- Higuchi, Hideo -- New York, N.Y. -- Science. 2010 Aug 6;329(5992):686-9. doi: 10.1126/science.1191484.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyou-ku, Tokyo, 113-0033 Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20689017" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*physiology ; Actomyosin/chemistry/physiology ; Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Compliance ; Elasticity ; Models, Biological ; *Muscle Contraction ; Muscle Fibers, Skeletal/chemistry/physiology ; Muscle, Skeletal ; Myosin Subfragments/physiology ; Myosins/chemistry/*physiology ; Quantum Dots ; Rabbits
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  • 19
    Publication Date: 2010-05-07
    Description: The passive elasticity of muscle is largely governed by the I-band part of the giant muscle protein titin, a complex molecular spring composed of a series of individually folded immunoglobulin-like domains as well as largely unstructured unique sequences. These mechanical elements have distinct mechanical properties, and when combined, they provide the desired passive elastic properties of muscle, which are a unique combination of strength, extensibility and resilience. Single-molecule atomic force microscopy (AFM) studies demonstrated that the macroscopic behaviour of titin in intact myofibrils can be reconstituted by combining the mechanical properties of these mechanical elements measured at the single-molecule level. Here we report artificial elastomeric proteins that mimic the molecular architecture of titin through the combination of well-characterized protein domains GB1 and resilin. We show that these artificial elastomeric proteins can be photochemically crosslinked and cast into solid biomaterials. These biomaterials behave as rubber-like materials showing high resilience at low strain and as shock-absorber-like materials at high strain by effectively dissipating energy. These properties are comparable to the passive elastic properties of muscles within the physiological range of sarcomere length and so these materials represent a new muscle-mimetic biomaterial. The mechanical properties of these biomaterials can be fine-tuned by adjusting the composition of the elastomeric proteins, providing the opportunity to develop biomaterials that are mimetic of different types of muscles. We anticipate that these biomaterials will find applications in tissue engineering as scaffold and matrix for artificial muscles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lv, Shanshan -- Dudek, Daniel M -- Cao, Yi -- Balamurali, M M -- Gosline, John -- Li, Hongbin -- Canadian Institutes of Health Research/Canada -- England -- Nature. 2010 May 6;465(7294):69-73. doi: 10.1038/nature09024.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20445626" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biocompatible Materials/chemical synthesis/*chemistry ; Biomechanical Phenomena ; Biomimetics/methods ; Biopolymers/*chemistry ; Connectin ; Drosophila melanogaster/genetics ; Elasticity ; Muscle Proteins/*chemistry ; Polyproteins/chemistry ; Protein Kinases/*chemistry ; Stress, Mechanical
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  • 20
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    Nature Publishing Group (NPG)
    Publication Date: 2010-05-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chaikof, Elliot L -- England -- Nature. 2010 May 6;465(7294):44-5. doi: 10.1038/465044a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20445620" target="_blank"〉PubMed〈/a〉
    Keywords: Biomimetic Materials/*chemistry ; Connectin ; Elasticity ; Muscle Proteins/chemistry ; Polymers/*chemistry ; Protein Kinases/chemistry
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2010-03-27
    Description: Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with the ability to be stretched, compressed, twisted, bent, and deformed into arbitrary shapes. Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated with elastomeric substrates, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments. Here, we review these strategies and describe applications of them in systems ranging from electronic eyeball cameras to deformable light-emitting displays. We conclude with some perspectives on routes to commercialization, new device opportunities, and remaining challenges for research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rogers, John A -- Someya, Takao -- Huang, Yonggang -- New York, N.Y. -- Science. 2010 Mar 26;327(5973):1603-7. doi: 10.1126/science.1182383.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL 61801, USA. jrogers@illinois.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20339064" target="_blank"〉PubMed〈/a〉
    Keywords: Biocompatible Materials ; Diagnostic Equipment ; Elasticity ; Elastomers ; *Electrical Equipment and Supplies ; Equipment Design ; Humans ; Mechanical Phenomena ; Nanostructures ; *Semiconductors ; Therapeutics/instrumentation
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-01
    Description: Mathew-Fenn et al. (Reports, 17 October 2008, p. 446) reported unexpected distance fluctuations in short end-labeled DNA constructs and interpreted them as evidence for cooperative DNA stretching modes. We show that when accounting for a subtle linker leverage effect, their data can be understood within standard noncooperative DNA elasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, Nils B -- Everaers, Ralf -- New York, N.Y. -- Science. 2009 Jul 31;325(5940):538; author reply 538. doi: 10.1126/science.1168786.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre Blaise Pascal et Laboratoire de Physique, CNRS UMR 5672, Ecole Normale Superieure, Universite de Lyon, 46 Allee d'Italie, 69007 Lyon, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19644093" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/*chemistry ; Elasticity ; Gold ; Metal Nanoparticles ; Models, Molecular ; Monte Carlo Method ; *Nucleic Acid Conformation ; Oligodeoxyribonucleotides/chemistry
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  • 23
    Publication Date: 2009-05-22
    Description: Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169427/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169427/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phillips, Rob -- Ursell, Tristan -- Wiggins, Paul -- Sens, Pierre -- DP1 OD000217/OD/NIH HHS/ -- DP1 OD000217-05/OD/NIH HHS/ -- R01 GM084211/GM/NIGMS NIH HHS/ -- R01 GM084211-04/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 May 21;459(7245):379-85. doi: 10.1038/nature08147.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA. phillips@pboc.caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19458714" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Membrane/*chemistry/*metabolism ; Elasticity ; Ion Channels/metabolism ; Membrane Lipids/*metabolism ; Membrane Proteins/*metabolism ; Thermodynamics
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  • 24
    Publication Date: 2009-03-21
    Description: Improved electrically powered artificial muscles are needed for generating force, moving objects, and accomplishing work. Carbon nanotube aerogel sheets are the sole component of new artificial muscles that provide giant elongations and elongation rates of 220% and (3.7 x 10(4))% per second, respectively, at operating temperatures from 80 to 1900 kelvin. These solid-state-fabricated sheets are enthalpic rubbers having gaslike density and specific strength in one direction higher than those of steel plate. Actuation decreases nanotube aerogel density and can be permanently frozen for such device applications as transparent electrodes. Poisson's ratios reach 15, a factor of 30 higher than for conventional rubbers. These giant Poisson's ratios explain the observed opposite sign of width and length actuation and result in rare properties: negative linear compressibility and stretch densification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aliev, Ali E -- Oh, Jiyoung -- Kozlov, Mikhail E -- Kuznetsov, Alexander A -- Fang, Shaoli -- Fonseca, Alexandre F -- Ovalle, Raquel -- Lima, Marcio D -- Haque, Mohammad H -- Gartstein, Yuri N -- Zhang, Mei -- Zakhidov, Anvar A -- Baughman, Ray H -- New York, N.Y. -- Science. 2009 Mar 20;323(5921):1575-8. doi: 10.1126/science.1168312.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alan G. MacDiarmid NanoTech Institute, University of Texas at Dallas, Richardson, TX 75083, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19299612" target="_blank"〉PubMed〈/a〉
    Keywords: Biomimetic Materials/chemistry ; Elasticity ; Muscle, Skeletal ; *Nanotubes, Carbon/chemistry ; Static Electricity ; Temperature ; Tensile Strength
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-12-17
    Description: Cells sense the environment's mechanical stiffness to control their own shape, migration, and fate. To better understand stiffness sensing, we constructed a stochastic model of the "motor-clutch" force transmission system, where molecular clutches link F-actin to the substrate and mechanically resist myosin-driven F-actin retrograde flow. The model predicts two distinct regimes: (i) "frictional slippage," with fast retrograde flow and low traction forces on stiff substrates and (ii) oscillatory "load-and-fail" dynamics, with slower retrograde flow and higher traction forces on soft substrates. We experimentally confirmed these model predictions in embryonic chick forebrain neurons by measuring the nanoscale dynamics of single-growth-cone filopodia. Furthermore, we experimentally observed a model-predicted switch in F-actin dynamics around an elastic modulus of 1 kilopascal. Thus, a motor-clutch system inherently senses and responds to the mechanical stiffness of the local environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, Clarence E -- Odde, David J -- R01-GM-76177/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Dec 12;322(5908):1687-91. doi: 10.1126/science.1163595.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19074349" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*physiology ; Actins/*physiology ; Animals ; Biomechanical Phenomena ; Cell Adhesion ; Cells, Cultured ; Chick Embryo ; Compliance ; Computer Simulation ; Elastic Modulus ; Elasticity ; Growth Cones/*physiology/ultrastructure ; Models, Biological ; Myosin Type II/physiology ; Neurons/physiology ; Pseudopodia/*physiology ; Surface Tension
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  • 26
    Publication Date: 2008-12-06
    Description: The notion of mimicking natural structures in the synthesis of new structural materials has generated enormous interest but has yielded few practical advances. Natural composites achieve strength and toughness through complex hierarchical designs that are extremely difficult to replicate synthetically. We emulate nature's toughening mechanisms by combining two ordinary compounds, aluminum oxide and polymethyl methacrylate, into ice-templated structures whose toughness can be more than 300 times (in energy terms) that of their constituents. The final product is a bulk hybrid ceramic-based material whose high yield strength and fracture toughness [ approximately 200 megapascals (MPa) and approximately 30 MPa.m(1/2)] represent specific properties comparable to those of aluminum alloys. These model materials can be used to identify the key microstructural features that should guide the synthesis of bio-inspired ceramic-based composites with unique strength and toughness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Munch, E -- Launey, M E -- Alsem, D H -- Saiz, E -- Tomsia, A P -- Ritchie, R O -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1516-20. doi: 10.1126/science.1164865.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056979" target="_blank"〉PubMed〈/a〉
    Keywords: Aluminum Oxide/*chemistry ; Animals ; Calcium Carbonate/chemistry ; Ceramics/*chemistry ; Elasticity ; Freezing ; Gastropoda/chemistry ; Materials Testing ; Mechanical Phenomena ; Polymethyl Methacrylate/*chemistry
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  • 27
    Publication Date: 2008-05-20
    Description: Thin elastic membranes supported on a much softer elastic solid or a fluid deviate from their flat geometries upon compression. We demonstrate that periodic wrinkling is only one possible solution for such strained membranes. Folds, which involve highly localized curvature, appear whenever the membrane is compressed beyond a third of its initial wrinkle wavelength. Eventually the surface transforms into a symmetry-broken state with flat regions of membrane coexisting with locally folded points, reminiscent of a crumpled, unsupported membrane. We provide general scaling laws for the wrinkled and folded states and proved the transition with numerical and experimental supported membranes. Our work provides insight into the interfacial stability of such diverse systems as biological membranes such as lung surfactant and nanoparticle thin films.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pocivavsek, Luka -- Dellsy, Robert -- Kern, Andrew -- Johnson, Sebastian -- Lin, Binhua -- Lee, Ka Yee C -- Cerda, Enrique -- New York, N.Y. -- Science. 2008 May 16;320(5878):912-6. doi: 10.1126/science.1154069.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and James Franck Institute (JFI), University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18487188" target="_blank"〉PubMed〈/a〉
    Keywords: Elasticity ; Gels ; Lipids/chemistry ; Mathematics ; *Membranes/chemistry ; *Membranes, Artificial ; Metal Nanoparticles/chemistry ; *Polyesters/chemistry ; Pulmonary Surfactants/chemistry ; Stress, Mechanical ; Thermodynamics ; Water
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  • 28
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisel, John W -- New York, N.Y. -- Science. 2008 Apr 25;320(5875):456-7. doi: 10.1126/science.1154210.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. weisel@mail.med.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18436761" target="_blank"〉PubMed〈/a〉
    Keywords: Biophysical Phenomena ; Biophysics ; Blood Coagulation/*physiology ; Computer Simulation ; Elasticity ; Fibrin/*chemistry ; Fibrinogen/*chemistry ; Humans ; Protein Folding ; Protein Structure, Tertiary
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  • 29
    Publication Date: 2008-03-29
    Description: We report here the self-assembly of macroscopic sacs and membranes at the interface between two aqueous solutions, one containing a megadalton polymer and the other, small self-assembling molecules bearing opposite charge. The resulting structures have a highly ordered architecture in which nanofiber bundles align and reorient by nearly 90 degrees as the membrane grows. The formation of a diffusion barrier upon contact between the two liquids prevents their chaotic mixing. We hypothesize that growth of the membrane is then driven by a dynamic synergy between osmotic pressure of ions and static self-assembly. These robust, self-sealing macroscopic structures offer opportunities in many areas, including the formation of privileged environments for cells, immune barriers, new biological assays, and self-assembly of ordered thick membranes for diverse applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capito, Ramille M -- Azevedo, Helena S -- Velichko, Yuri S -- Mata, Alvaro -- Stupp, Samuel I -- 5-P50-NS054287/NS/NINDS NIH HHS/ -- 5-R01-DE015920/DE/NIDCR NIH HHS/ -- 5-R01-EB003806/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 28;319(5871):1812-6. doi: 10.1126/science.1154586.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18369143" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Survival ; Chondrocytes/cytology ; Diffusion ; Elasticity ; Humans ; Hyaluronic Acid/*chemistry ; *Membranes, Artificial ; Mesenchymal Stromal Cells/cytology/physiology ; Microscopy, Electron ; Nanostructures/chemistry ; Osmotic Pressure ; Peptides/*chemistry ; Permeability ; Polymers/*chemistry ; Static Electricity ; Transforming Growth Factor beta1/chemistry
    Print ISSN: 0036-8075
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  • 30
    Publication Date: 2008-03-08
    Description: Sea cucumbers, like other echinoderms, have the ability to rapidly and reversibly alter the stiffness of their inner dermis. It has been proposed that the modulus of this tissue is controlled by regulating the interactions among collagen fibrils, which reinforce a low-modulus matrix. We report on a family of polymer nanocomposites, which mimic this architecture and display similar chemoresponsive mechanic adaptability. Materials based on a rubbery host polymer and rigid cellulose nanofibers exhibit a reversible reduction by a factor of 40 of the tensile modulus, for example, from 800 to 20 megapascals (MPa), upon exposure to a chemical regulator that mediates nanofiber interactions. Using a host polymer with a thermal transition in the regime of interest, we demonstrated even larger modulus changes (4200 to 1.6 MPa) upon exposure to emulated physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capadona, Jeffrey R -- Shanmuganathan, Kadhiravan -- Tyler, Dustin J -- Rowan, Stuart J -- Weder, Christoph -- R21 NS053798/NS/NINDS NIH HHS/ -- R21 NS053798-02/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 7;319(5868):1370-4. doi: 10.1126/science.1153307.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18323449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomimetic Materials/chemistry ; *Cellulose/chemistry ; Cerebrospinal Fluid ; Dermis ; Elasticity ; Epichlorohydrin/chemistry ; Ethylene Oxide/chemistry ; Hydrogen Bonding ; Microelectrodes ; *Nanocomposites/chemistry ; Phase Transition ; *Polymers/chemistry ; *Sea Cucumbers ; Solvents ; Stress, Mechanical ; Temperature ; Tensile Strength ; Urochordata
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  • 31
    Publication Date: 2008-02-22
    Description: Rubbers exhibit enormous extensibility up to several hundred per cent, compared with a few per cent for ordinary solids, and have the ability to recover their original shape and dimensions on release of stress. Rubber elasticity is a property of macromolecules that are either covalently cross-linked or connected in a network by physical associations such as small glassy or crystalline domains, ionic aggregates or multiple hydrogen bonds. Covalent cross-links or strong physical associations prevent flow and creep. Here we design and synthesize molecules that associate together to form both chains and cross-links via hydrogen bonds. The system shows recoverable extensibility up to several hundred per cent and little creep under load. In striking contrast to conventional cross-linked or thermoreversible rubbers made of macromolecules, these systems, when broken or cut, can be simply repaired by bringing together fractured surfaces to self-heal at room temperature. Repaired samples recuperate their enormous extensibility. The process of breaking and healing can be repeated many times. These materials can be easily processed, re-used and recycled. Their unique self-repairing properties, the simplicity of their synthesis, their availability from renewable resources and the low cost of raw ingredients (fatty acids and urea) bode well for future applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cordier, Philippe -- Tournilhac, Francois -- Soulie-Ziakovic, Corinne -- Leibler, Ludwik -- England -- Nature. 2008 Feb 21;451(7181):977-80. doi: 10.1038/nature06669.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Matiere Molle et Chimie, UMR 7167 CNRS-ESPCI, Ecole Superieure de Physique et Chimie Industrielles, 10 rue Vauquelin, 75005 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18288191" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallization ; Elasticity ; Fatty Acids/chemistry ; Hydrogen Bonding ; Mechanics ; Rheology ; Rubber/*chemistry ; Temperature ; Urea/chemistry
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 32
    Publication Date: 2008-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mynar, Justin L -- Aida, Takuzo -- England -- Nature. 2008 Feb 21;451(7181):895-6. doi: 10.1038/451895a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18288172" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Conservation of Natural Resources ; Elasticity ; Hydrogen Bonding ; Mechanics ; Rubber/*chemistry ; Temperature
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
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  • 33
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaia, Richard -- Baur, Jeffery -- New York, N.Y. -- Science. 2008 Jan 25;319(5862):420-1. doi: 10.1126/science.1152931.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, OH 45433, USA. richard.vaia@wpafb.af.mil〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18218885" target="_blank"〉PubMed〈/a〉
    Keywords: Biomimetic Materials ; Elasticity ; Elastomers ; *Nanostructures ; *Polymers ; Temperature
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  • 34
    Publication Date: 2007-12-22
    Description: Protein molecules have the ability to form a rich variety of natural and artificial structures and materials. We show that amyloid fibrils, ordered supramolecular nanostructures that are self-assembled from a wide range of polypeptide molecules, have rigidities varying over four orders of magnitude, and constitute a class of high-performance biomaterials. We elucidate the molecular origin of fibril material properties and show that the major contribution to their rigidity stems from a generic interbackbone hydrogen-bonding network that is modulated by variable side-chain interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knowles, Tuomas P -- Fitzpatrick, Anthony W -- Meehan, Sarah -- Mott, Helen R -- Vendruscolo, Michele -- Dobson, Christopher M -- Welland, Mark E -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Dec 21;318(5858):1900-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nanoscience Centre, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0FF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18096801" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/*chemistry ; Amyloid beta-Peptides/chemistry ; Chemistry, Physical ; Elasticity ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Insulin/chemistry ; Lactalbumin/chemistry ; Lactoglobulins/chemistry ; Microscopy, Atomic Force ; Models, Molecular ; Muramidase/chemistry ; Nanostructures/*chemistry ; Peptide Termination Factors ; Peptides/*chemistry ; Physicochemical Phenomena ; Prealbumin/chemistry ; Prions/chemistry ; Protein Conformation ; Protein Structure, Tertiary ; Saccharomyces cerevisiae Proteins/chemistry ; Surface Tension ; alpha-Crystallin B Chain/chemistry
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  • 35
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-05-26
    Description: Single-molecule force experiments in vitro enable the characterization of the mechanical response of biological matter at the nanometer scale. However, they do not reveal the molecular mechanisms underlying mechanical function. These can only be readily studied through molecular dynamics simulations of atomic structural models: "in silico" (by computer analysis) single-molecule experiments. Steered molecular dynamics simulations, in which external forces are used to explore the response and function of macromolecules, have become a powerful tool complementing and guiding in vitro single-molecule experiments. The insights provided by in silico experiments are illustrated here through a review of recent research in three areas of protein mechanics: elasticity of the muscle protein titin and the extracellular matrix protein fibronectin; linker-mediated elasticity of the cytoskeleton protein spectrin; and elasticity of ankyrin repeats, a protein module found ubiquitously in cells but with an as-yet unclear function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sotomayor, Marcos -- Schulten, Klaus -- 1 R01 GM073655/GM/NIGMS NIH HHS/ -- P41 RR05969/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2007 May 25;316(5828):1144-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Illinois at Urbana-Champaign, and Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17525328" target="_blank"〉PubMed〈/a〉
    Keywords: Ankyrin Repeat/*physiology ; Computer Simulation ; Connectin ; Elasticity ; Fibronectins/*physiology ; Humans ; Models, Biological ; Muscle Proteins/*physiology ; Protein Kinases/*physiology ; Spectrin/*physiology ; Spectrum Analysis/*methods
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  • 36
    Publication Date: 2007-01-20
    Description: Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate-dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mizuno, Daisuke -- Tardin, Catherine -- Schmidt, C F -- Mackintosh, F C -- New York, N.Y. -- Science. 2007 Jan 19;315(5810):370-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, Vrije Universiteit, 1081HV Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17234946" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*physiology ; Actins/*physiology ; Adenosine Triphosphate/*metabolism ; Biomechanical Phenomena ; Cytoskeleton/*physiology ; Elasticity ; Mathematics ; *Models, Biological ; Molecular Motor Proteins/*physiology ; Myosin Type II/*physiology ; Rheology ; Stress, Mechanical ; Viscosity
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  • 37
    Publication Date: 2006-08-05
    Description: Blood clots perform an essential mechanical task, yet the mechanical behavior of fibrin fibers, which form the structural framework of a clot, is largely unknown. By using combined atomic force-fluorescence microscopy, we determined the elastic limit and extensibility of individual fibers. Fibrin fibers can be strained 180% (2.8-fold extension) without sustaining permanent lengthening, and they can be strained up to 525% (average 330%) before rupturing. This is the largest extensibility observed for protein fibers. The data imply that fibrin monomers must be able to undergo sizeable, reversible structural changes and that deformations in clots can be accommodated by individual fiber stretching.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950267/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950267/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, W -- Jawerth, L M -- Sparks, E A -- Falvo, M R -- Hantgan, R R -- Superfine, R -- Lord, S T -- Guthold, M -- P41 EB002025/EB/NIBIB NIH HHS/ -- R01 HL31048/HL/NHLBI NIH HHS/ -- R41 CA10312/CA/NCI NIH HHS/ -- R41 CA103120/CA/NCI NIH HHS/ -- R41 CA103120-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2006 Aug 4;313(5787):634.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16888133" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Coagulation ; Elasticity ; Factor XIII/chemistry ; Fibrin/*chemistry ; Microscopy, Atomic Force ; Stress, Mechanical
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  • 38
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-06-24
    Description: The orb web is a spectacular evolutionary innovation that enables spiders to catch flying prey. This elegant, geometric structure is woven with silk fibers that are renowned for their superior mechanical properties. We used silk gland expression libraries to address a long-standing controversy concerning the evolution of the orb-web architecture. Contrary to the view that the orb-web design evolved multiple times, we found that the distribution and phylogeny of silk proteins support a single, ancient origin of the orb web at least 136 million years ago. Furthermore, we substantially expanded the repository of silk sequences that can be used for the synthesis of high-performance biomaterials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Penalver, Enrique -- Grimaldi, David A -- Delclos, Xavier -- New York, N.Y. -- Science. 2006 Jun 23;312(5781):1761.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, American Museum of Natural History, New York, NY 10024, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16794072" target="_blank"〉PubMed〈/a〉
    Keywords: *Amber ; Animals ; Biological Evolution ; Elasticity ; *Fossils ; Insects ; Mites ; Selection, Genetic ; *Silk ; *Spiders/classification/genetics
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  • 39
    Publication Date: 2006-03-11
    Description: A biosynthetic approach was developed to control and probe cooperativity in multiunit biomotor assemblies by linking molecular motors to artificial protein scaffolds. This approach provides precise control over spatial and elastic coupling between motors. Cooperative interactions between monomeric kinesin-1 motors attached to protein scaffolds enhance hydrolysis activity and microtubule gliding velocity. However, these interactions are not influenced by changes in the elastic properties of the scaffold, distinguishing multimotor transport from that powered by unorganized monomeric motors. These results highlight the role of supramolecular architecture in determining mechanisms of collective transport.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diehl, Michael R -- Zhang, Kechun -- Lee, Heun Jin -- Tirrell, David A -- New York, N.Y. -- Science. 2006 Mar 10;311(5766):1468-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. diehl@rice.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16527982" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/chemistry ; Amino Acid Sequence ; Elasticity ; Elastin/chemistry ; Hydrolysis ; Kinesin/chemistry ; Microtubules/physiology ; Models, Biological ; Molecular Motor Proteins/*physiology ; Molecular Sequence Data ; Protein Engineering ; Protein Structure, Tertiary ; Proteins/chemistry/*physiology ; Recombinant Proteins/chemistry ; Structure-Activity Relationship
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  • 40
    Publication Date: 2005-12-13
    Description: Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R P -- Schaap, I A T -- Tardin, C F -- Erben, C M -- Berry, R M -- Schmidt, C F -- Turberfield, A J -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1661-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford OX1 3PU, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339440" target="_blank"〉PubMed〈/a〉
    Keywords: Base Pairing ; Base Sequence ; Chemistry, Physical ; DNA/*chemistry ; Dimerization ; Elasticity ; Microscopy, Atomic Force ; Models, Molecular ; Molecular Structure ; *Nanostructures ; *Nanotechnology ; Nucleic Acid Conformation ; Nucleic Acid Hybridization ; Oligodeoxyribonucleotides/chemistry ; Physicochemical Phenomena ; Stereoisomerism
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  • 41
    Publication Date: 2005-11-19
    Description: Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby's skin. The behavior of some cells on soft materials is characteristic of important phenotypes; for example, cell growth on soft agar gels is used to identify cancer cells. However, an understanding of how tissue cells-including fibroblasts, myocytes, neurons, and other cell types-sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels (or to other cells) with which elasticity can be tuned to approximate that of tissues. Key roles in molecular pathways are played by adhesion complexes and the actinmyosin cytoskeleton, whose contractile forces are transmitted through transcellular structures. The feedback of local matrix stiffness on cell state likely has important implications for development, differentiation, disease, and regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Discher, Dennis E -- Janmey, Paul -- Wang, Yu-Li -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1139-43.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104-6315, USA. discher@seas.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293750" target="_blank"〉PubMed〈/a〉
    Keywords: Biomechanical Phenomena ; Cell Adhesion ; Cell Communication ; *Cell Physiological Phenomena ; Cytoskeleton/physiology ; Elasticity ; Humans ; Muscle Contraction/physiology ; Organogenesis/physiology
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  • 42
    Publication Date: 2005-05-28
    Description: The typical scales for plant and fungal movements vary over many orders of magnitude in time and length, but they are ultimately based on hydraulics and mechanics. We show that quantification of the length and time scales involved in plant and fungal motions leads to a natural classification, whose physical basis can be understood through an analysis of the mechanics of water transport through an elastic tissue. Our study also suggests a design principle for nonmuscular hydraulically actuated structures: Rapid actuation requires either small size or the enhancement of motion on large scales via elastic instabilities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skotheim, Jan M -- Mahadevan, L -- New York, N.Y. -- Science. 2005 May 27;308(5726):1308-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge CB3 0WA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15919993" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Wall/physiology ; Droseraceae/anatomy & histology/physiology ; Elasticity ; Euphorbiaceae/anatomy & histology/physiology ; Fungi/cytology/*physiology ; Mathematics ; Movement ; Mucorales/cytology/physiology ; Physical Phenomena ; Physics ; Plant Leaves/*physiology ; *Plant Physiological Phenomena ; Plants/anatomy & histology ; Pressure ; Time Factors ; Viscosity ; Water/*physiology
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  • 43
    Publication Date: 2005-03-26
    Description: Soft tissues are preserved within hindlimb elements of Tyrannosaurus rex (Museum of the Rockies specimen 1125). Removal of the mineral phase reveals transparent, flexible, hollow blood vessels containing small round microstructures that can be expressed from the vessels into solution. Some regions of the demineralized bone matrix are highly fibrous, and the matrix possesses elasticity and resilience. Three populations of microstructures have cell-like morphology. Thus, some dinosaurian soft tissues may retain some of their original flexibility, elasticity, and resilience.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schweitzer, Mary H -- Wittmeyer, Jennifer L -- Horner, John R -- Toporski, Jan K -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1952-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Marine, Earth, Atmospheric Sciences, North Carolina State University, Raleigh, NC 27695, USA. schweitzer@ncsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790853" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Vessels/*anatomy & histology/cytology ; Bone Demineralization Technique ; Bone Matrix ; Bone and Bones/anatomy & histology/*blood supply/*cytology ; Cell Separation ; DNA/analysis ; Dinosaurs/*anatomy & histology ; Elasticity ; Femur/anatomy & histology/blood supply ; *Fossils ; Microscopy, Electron, Scanning ; Montana ; Osteocytes/*cytology/ultrastructure ; Time
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 44
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-19
    Description: In origami, form follows the sequential spatial organization of folds. This requires continuous intervention and raises a natural question: Can origami arise through self-organization? We answer this affirmatively by examining the possible physical origin for the Miura-ori leaf-folding patterns that arise naturally in insect wings, leaves, and other laminae-like organelles. In particular, we point out examples where biaxial compression of an elastically supported thin film, such as that due to differential growth, shrinkage, desiccation, or thermal expansion, spontaneously generates these patterns, and we provide a simple theoretical explanation for their occurrence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mahadevan, L -- Rica, S -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1740.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Engineering and Applied Sciences and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. lm@deas.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774751" target="_blank"〉PubMed〈/a〉
    Keywords: Betulaceae/anatomy & histology/physiology ; Elasticity ; Mathematics ; Plant Leaves/anatomy & histology/*physiology ; Stress, Mechanical
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  • 45
    Publication Date: 2004-05-29
    Description: Networks of cross-linked and bundled actin filaments are ubiquitous in the cellular cytoskeleton, but their elasticity remains poorly understood. We show that these networks exhibit exceptional elastic behavior that reflects the mechanical properties of individual filaments. There are two distinct regimes of elasticity, one reflecting bending of single filaments and a second reflecting stretching of entropic fluctuations of filament length. The mechanical stiffness can vary by several decades with small changes in cross-link concentration, and can increase markedly upon application of external stress. We parameterize the full range of behavior in a state diagram and elucidate its origin with a robust model.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gardel, M L -- Shin, J H -- MacKintosh, F C -- Mahadevan, L -- Matsudaira, P -- Weitz, D A -- GM52703/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 May 28;304(5675):1301-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166374" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*chemistry/metabolism ; Actins/*chemistry/metabolism ; Biopolymers/chemistry/metabolism ; Elasticity ; Entropy ; Mathematics ; Microfilament Proteins/chemistry/metabolism ; Models, Biological ; Stress, Mechanical
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  • 46
    Publication Date: 2002-11-02
    Description: We present an approach to fabricate solid capsules with precise control of size, permeability, mechanical strength, and compatibility. The capsules are fabricated by the self-assembly of colloidal particles onto the interface of emulsion droplets. After the particles are locked together to form elastic shells, the emulsion droplets are transferred to a fresh continuous-phase fluid that is the same as that inside the droplets. The resultant structures, which we call "colloidosomes," are hollow, elastic shells whose permeability and elasticity can be precisely controlled. The generality and robustness of these structures and their potential for cellular immunoisolation are demonstrated by the use of a variety of solvents, particles, and contents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dinsmore, A D -- Hsu, Ming F -- Nikolaides, M G -- Marquez, Manuel -- Bausch, A R -- Weitz, D A -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1006-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA. dinsmore@physics.umass.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411700" target="_blank"〉PubMed〈/a〉
    Keywords: Adsorption ; *Capsules ; Cell Physiological Phenomena ; Cell Survival ; Cells, Cultured ; Chemistry, Physical ; *Colloids ; Diffusion ; Elasticity ; Emulsions ; Fibroblasts/physiology ; Microscopy, Confocal ; Microscopy, Electron, Scanning ; Permeability ; Physicochemical Phenomena ; Polylysine ; Polymethyl Methacrylate ; Surface Properties ; Water
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 47
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alper, Joe -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130765" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Chemistry, Physical ; Collagen/chemistry ; Elasticity ; Elastin/chemistry ; *Fibroins ; Insect Proteins/chemistry ; Microfilament Proteins/chemistry ; Physicochemical Phenomena ; Polymers/*chemistry ; *Protein Conformation ; *Protein Engineering ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteins/*chemistry ; Recombinant Proteins/chemistry ; Repetitive Sequences, Amino Acid ; Stress, Mechanical
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  • 48
    Publication Date: 2002-04-27
    Description: The introduction of biodegradable implant materials as well as minimally invasive surgical procedures in medicine has substantially improved health care within the past few decades. This report describes a group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature. Their shape-memory capability enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically. A smart degradable suture was created to illustrate the potential of these shape-memory thermoplastics in biomedical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lendlein, Andreas -- Langer, Robert -- New York, N.Y. -- Science. 2002 May 31;296(5573):1673-6. Epub 2002 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉mnemoScience GmbH, Pauwelsstrabetae 19, D-52074 Aachen, Germany. a.lendlein@mnemoscience.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976407" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biocompatible Materials/chemical synthesis/chemistry ; Chemistry, Physical ; Dioxanes/chemistry ; Elasticity ; Elastomers ; Isocyanates/chemistry ; Mechanics ; Physicochemical Phenomena ; Polyesters/chemistry ; *Polymers/chemical synthesis/chemistry ; *Prostheses and Implants ; Rats ; Stress, Mechanical ; *Sutures ; Temperature ; Thermodynamics
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  • 49
    Publication Date: 2002-01-19
    Description: Spider silks are protein-based "biopolymer" filaments or threads secreted by specialized epithelial cells as concentrated soluble precursors of highly repetitive primary sequences. Spider dragline silk is a flexible, lightweight fiber of extraordinary strength and toughness comparable to that of synthetic high-performance fibers. We sought to "biomimic" the process of spider silk production by expressing in mammalian cells the dragline silk genes (ADF-3/MaSpII and MaSpI) of two spider species. We produced soluble recombinant (rc)-dragline silk proteins with molecular masses of 60 to 140 kilodaltons. We demonstrated the wet spinning of silk monofilaments spun from a concentrated aqueous solution of soluble rc-spider silk protein (ADF-3; 60 kilodaltons) under modest shear and coagulation conditions. The spun fibers were water insoluble with a fine diameter (10 to 40 micrometers) and exhibited toughness and modulus values comparable to those of native dragline silks but with lower tenacity. Dope solutions with rc-silk protein concentrations 〉20% and postspinning draw were necessary to achieve improved mechanical properties of the spun fibers. Fiber properties correlated with finer fiber diameter and increased birefringence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazaris, Anthoula -- Arcidiacono, Steven -- Huang, Yue -- Zhou, Jiang-Feng -- Duguay, Francois -- Chretien, Nathalie -- Welsh, Elizabeth A -- Soares, Jason W -- Karatzas, Costas N -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):472-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nexia Biotechnologies, Vaudreuil-Dorion, Quebec J7V 8P5, Canada. alazaris@nexiabiotech.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799236" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Biopolymers ; Birefringence ; Cattle ; Cell Line ; Cloning, Molecular ; Cricetinae ; Culture Media, Conditioned ; DNA, Complementary ; Elasticity ; Epithelial Cells/metabolism ; *Fibroins ; Materials Testing ; Mechanics ; Molecular Sequence Data ; Molecular Weight ; *Protein Biosynthesis ; Protein Structure, Secondary ; Proteins/chemistry/*genetics/isolation & purification ; Recombinant Proteins/biosynthesis/chemistry/isolation & purification ; Solubility ; Spiders/*genetics/metabolism ; Stress, Mechanical ; Tensile Strength ; Water
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-09-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, G -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546850" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cooking ; Elasticity ; Fats/metabolism ; *Food ; Food Analysis ; *Food Preferences/physiology/psychology ; Hot Temperature ; Humans ; Perception ; *Research ; *Sensation ; Smell ; Taste ; Viscosity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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