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  • American Association for the Advancement of Science (AAAS)  (24,137)
  • Annual Reviews
  • 1990-1994  (18,406)
  • 1980-1984  (15,028)
  • 1945-1949  (614)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1993-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, J -- New York, N.Y. -- Science. 1993 Dec 10;262(5140):1646.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8259508" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Toxins/*chemistry/genetics/metabolism ; Cell Membrane/metabolism ; Hemolysin Proteins/*chemistry/genetics/metabolism ; Mutagenesis ; *Protein Engineering
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1993-07-02
    Description: The photographs accompanying the Research News article "New Altzheimer's therapy suggested" by Jim Schnabel (18 June, p. 1719) were printed incorrectly so that their order was reversed. Joe Rogers appeared at the top, and Patrick McGeer below.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1993 Jul 2;261(5117):15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17750527" target="_blank"〉PubMed〈/a〉
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  • 3
    Publication Date: 1994-02-25
    Description: Activation of the serine-threonine kinase p34cdc2 at an inappropriate time during the cell cycle leads to cell death that resembles apoptosis. Premature activation of p34cdc2 was shown to be required for apoptosis induced by a lymphocyte granule protease. The kinase was rapidly activated and tyrosine dephosphorylated at the initiation of apoptosis. DNA fragmentation and nuclear collapse could be prevented by blocking p34cdc2 activity with excess peptide substrate, or by inactivating p34cdc2 in a temperature-sensitive mutant. Premature p34cdc2 activation may be a general mechanism by which cells induced to undergo apoptosis initiate the disruption of the nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shi, L -- Nishioka, W K -- Th'ng, J -- Bradbury, E M -- Litchfield, D W -- Greenberg, A H -- New York, N.Y. -- Science. 1994 Feb 25;263(5150):1143-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8108732" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Apoptosis ; CDC2 Protein Kinase/*metabolism ; DNA Damage ; Deoxyribonucleases/pharmacology ; Enzyme Activation ; Enzyme Induction ; Membrane Glycoproteins/pharmacology ; Mice ; Mitosis ; Molecular Sequence Data ; Perforin ; Phosphorylation ; Pore Forming Cytotoxic Proteins ; Serine Endopeptidases/pharmacology ; Tumor Cells, Cultured
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1994-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Apr 15;264(5157):342.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836890" target="_blank"〉PubMed〈/a〉
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1990 Jan 26;247(4941):408-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2405484" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*drug therapy/metabolism ; Amyloid/metabolism ; Amyloid beta-Peptides ; Animals ; Clinical Trials as Topic ; Humans ; Nerve Growth Factors/adverse effects/*therapeutic use ; Recombinant Proteins
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Sep 7;249(4973):1101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2204112" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; *National Institutes of Health (U.S.) ; United States
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 30;247(4950):1539.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11642762" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; *Animal Welfare ; Animals ; Humans ; Literature ; *Primates ; *Statistics as Topic ; Substance-Related Disorders ; United States
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, S -- New York, N.Y. -- Science. 1990 Mar 9;247(4947):1179.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17809262" target="_blank"〉PubMed〈/a〉
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 23;247(4949):1489.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17791215" target="_blank"〉PubMed〈/a〉
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  • 10
    Publication Date: 1990-08-10
    Description: The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To delineate alpha chain regulatory regions responsible for control of phospholipase A2, chimeric cDNAs were constructed in which different lengths of the alpha subunit of Gs (alpha s) were replaced with the corresponding sequence of the Gi alpha subunit (alpha i2). When a carboxyl-terminal chimera alpha s-i(38), which has the last 38 amino acids of alpha s substituted with the last 36 residues of alpha i2, was expressed in Chinese hamster ovary cells, the receptor-stimulated phospholipase A2 activity was inhibited, although the chimera could still activate adenylyl cyclase. Thus, alpha s-i(38) is an active alpha s, but also a dominant negative alpha i molecule, indicating that the last 36 amino acids of alpha i2 are a critical domain for G protein regulation of phospholipase A2 activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, S K -- Diez, E -- Heasley, L E -- Osawa, S -- Johnson, G L -- DK37871/DK/NIDDK NIH HHS/ -- GM30324/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):662-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2166341" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/pharmacology ; Animals ; Arachidonic Acid ; Arachidonic Acids/metabolism ; Cell Line ; Chlorides/pharmacology ; Enzyme Activation ; GTP-Binding Proteins/*genetics/metabolism ; Inositol Phosphates/metabolism ; Kinetics ; Lithium/pharmacology ; Lithium Chloride ; Macromolecular Substances ; *Mutation ; Phospholipases/*metabolism ; Phospholipases A/*metabolism ; Phospholipases A2 ; Receptors, Purinergic/drug effects/*physiology ; Restriction Mapping ; Thrombin/antagonists & inhibitors/*pharmacology ; Transfection
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  • 11
    Publication Date: 1990-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pisano, G P -- New York, N.Y. -- Science. 1990 Mar 9;247(4947):1241-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17809279" target="_blank"〉PubMed〈/a〉
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Jul 20;249(4966):240-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2374923" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Editorial Policies ; Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; Periodicals as Topic ; Politics ; Scientific Misconduct/*legislation & jurisprudence ; United States ; Universities
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  • 13
    Publication Date: 1990-08-17
    Description: The transcription factor C/EBP uses a bipartite structural motif to bind DNA. Two protein chains dimerize through a set of amphipathic alpha helices termed the leucine zipper. Highly basic polypeptide regions emerge from the zipper to form a linked set of DNA contact surfaces. In the recently proposed a "scissors grip" model, the paired set of basic regions begin DNA contact at a central point and track in opposite directions along the major groove, forming a molecular clamp around DNA. This model predicts that C/EBP must undertake significant changes in protein conformation as it binds and releases DNA. The basic region of ligand-free C/EBP is highly sensitive to protease digestion. Pronounced resistance to proteolysis occurred when C/EBP associated with its specific DNA substrate. Sequencing of discrete proteolytic fragments showed that prominent sites for proteolysis occur at two junction points predicted by the "scissors grip" model. One junction corresponds to the cleft where the basic regions emerge from the leucine zipper. The other corresponds to a localized nonhelical segment that has been hypothesized to contain an N-cap and facilitate the sharp angulation necessary for the basic region to track continuously in the major groove of DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shuman, J D -- Vinson, C R -- McKnight, S L -- New York, N.Y. -- Science. 1990 Aug 17;249(4970):771-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Research Laboratories, Department of Embryology, Baltimore, MD 21210.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2202050" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; CCAAT-Enhancer-Binding Proteins ; Chromatography, High Pressure Liquid ; DNA/*metabolism ; DNA-Binding Proteins/metabolism ; Kinetics ; Leucine ; Macromolecular Substances ; Models, Molecular ; Molecular Sequence Data ; Nuclear Proteins/*metabolism ; Peptide Fragments/metabolism ; Peptide Hydrolases/*metabolism ; Protein Conformation ; Transcription Factors/*metabolism ; Trypsin/metabolism
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  • 14
    Publication Date: 1990-10-12
    Description: The mechanism by which phytohormones, like abscisic acid (ABA), regulate gene expression is unknown. An activity in nuclear extracts that interacts with the ABA response element (ABRE) from the 5' regulatory region of the wheat Em gene was identified. A complementary DNA clone was isolated whose product is a DNA binding protein (EmBP-1) that interacts specifically with an 8-base pair (bp) sequence (CACGTGGC) in the ABRE. A 2-bp mutation in this sequence prevented binding of EmBP-1. The same mutation reduced the ability of the ABRE to confer ABA responsiveness on a viral promoter in a transient assay. The 8-bp EmBP-1 target sequence was found to be conserved in several other ABA-responsive promoters and in promoters from plants that respond to signals other than ABA. Similar sequences are found in promoters from mammals, yeast, and in the major late promoter of adenovirus. The deduced amino acid sequence of EmBP-1 contains conserved basic and leucine zipper domains found in transcription factors in plants, yeast, and mammals. EmBP-1 may be a member of a highly conserved family of proteins that recognize a core sequence found in the regulatory regions of various genes that are integrated into a number of different response pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guiltinan, M J -- Marcotte, W R Jr -- Quatrano, R S -- New York, N.Y. -- Science. 1990 Oct 12;250(4978):267-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of North Carolina, Chapel Hill 27599-3280.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2145628" target="_blank"〉PubMed〈/a〉
    Keywords: Abscisic Acid/*metabolism ; Amino Acid Sequence ; Base Sequence ; Cell Nucleus/metabolism ; DNA/*genetics ; DNA-Binding Proteins/genetics/metabolism ; *Gene Expression Regulation ; *Leucine Zippers/genetics ; Molecular Sequence Data ; Oligonucleotide Probes ; Plants/*genetics ; Sequence Homology, Nucleic Acid ; Triticum/*genetics/metabolism
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-02
    Description: The RNA moiety of the ribonucleoprotein enzyme telomerase from the ciliate Euplotes crassus was identified and its gene was sequenced. Functional analysis, in which oligonucleotides complementary to portions of the telomerase RNA were tested for their ability to prime telomerase in vitro, showed that the sequence 5' CAAAACCCCAAA 3' in this RNA is the template for synthesis of telomeric TTTTGGGG repeats by the Euplotes telomerase. The data provide a direct demonstration of a template function for a telomerase RNA and demarcate the outer boundaries of the telomeric template. Telomerase can now be defined as a specialized reverse transcriptase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shippen-Lentz, D -- Blackburn, E H -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):546-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1689074" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Ciliophora/enzymology/*genetics ; DNA Nucleotidylexotransferase/*genetics ; Genes ; Molecular Sequence Data ; Oligonucleotide Probes ; RNA/*genetics ; Sequence Homology, Nucleic Acid ; *Templates, Genetic
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  • 16
    Publication Date: 1990-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, B A -- Blanke, S R -- Murphy, J R -- Pappenheimer, A M Jr -- Collier, R J -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):834-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759975" target="_blank"〉PubMed〈/a〉
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Jun 29;248(4963):1599.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2363045" target="_blank"〉PubMed〈/a〉
    Keywords: Great Britain ; *National Institutes of Health (U.S.) ; Periodicals as Topic ; Politics ; Publishing ; *Scientific Misconduct ; United States ; United States Dept. of Health and Human Services
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  • 18
    Publication Date: 1990-10-19
    Description: Nitrogen and methane ices on the surface of Triton, Neptune's largest satellite, are exchanged between the summer and winter hemispheres on a seasonal time scale. Images of the satellite's sky obtained by the Voyager 2 spacecraft show the presence of several types of scattering materials that provide insights into this seasonal cycle of volatiles. Discrete clouds, probably composed of N(2) ice particles, arise in regions of active sublimation. They are found chiefly poleward of 30 degrees S in the southern, summer hemisphere. Haze particles, probably made of hydrocarbon ices, are present above most, but not all places. Recent snowfall may have occurred at low southern latitudes in places where they are absent. The latent heat released in the formation of the discrete clouds may have a major impact on the thermal balance of the lower atmosphere. Triton may have been less red at the time of the Voyager flyby than 12 years earlier due to recent N(2) snowfall at a wide range of latitudes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollack, J B -- Schwartz, J M -- Rages, K -- New York, N.Y. -- Science. 1990 Oct 19;250(4979):440-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17793024" target="_blank"〉PubMed〈/a〉
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1990 Apr 27;248(4954):445.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17815587" target="_blank"〉PubMed〈/a〉
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  • 20
    Publication Date: 1990-06-15
    Description: The Mojave block of southern California has undergone significant late Cenozoic north-south contraction. This previously unappreciated deformation may account for part of the discrepancy between neotectonic and plate-tectonic estimates of Pacific-North American plate motion, and for part of the Big Bend in the San Andreas fault. In the eastern Mojave block, contraction is superimposed on early Miocene crustal extension. In the western Mojave block, contractional folds and reverse faults have been mistaken for extensional structures. The three-dimensional complexity of the contractional structures may mean that rigid-block tectonic models of the region based primarily on paleomagnetic data are unreliable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartley, J M -- Glazner, A F -- Schermer, E R -- New York, N.Y. -- Science. 1990 Jun 15;248(4961):1398-401.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17747526" target="_blank"〉PubMed〈/a〉
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 14;249(4974):1243.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835532" target="_blank"〉PubMed〈/a〉
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1990 Dec 21;250(4988):1655-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2270476" target="_blank"〉PubMed〈/a〉
    Keywords: *Blood Substitutes/adverse effects ; Hemoglobins/*therapeutic use ; Humans ; National Institutes of Health (U.S.) ; United States ; United States Food and Drug Administration
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-12-21
    Description: Within the framework of neo-Darwinism, with its focus on fitness, it has been hard to account for altruism behavior that reduces the fitness of the altruist but increases average fitness in society. Many population biologists argue that, except for altruism to close relatives, human behavior that appears to be altruistic amounts to reciprocal altruism, behavior undertaken with an expectation of reciprocation, hence incurring no net cost to fitness. Herein is proposed a simple and robust mechanism, based on human docility and bounded rationality that can account for the evolutionary success of genuinely altruistic behavior. Because docility-receptivity to social influence-contributes greatly to fitness in the human species, it will be positively selected. As a consequence, society can impose a "tax" on the gross benefits gained by individuals from docility by inducing docile individuals to engage in altruistic behaviors. Limits on rationality in the face of environmental complexity prevent the individual from avoiding this "tax." An upper bound is imposed on altruism by the condition that there must remain a net fitness advantage for docile behavior after the cost to the individual of altruism has been deducted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon, H A -- New York, N.Y. -- Science. 1990 Dec 21;250(4988):1665-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Carnegie-Mellon University, Pittsburgh, PA 15213.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2270480" target="_blank"〉PubMed〈/a〉
    Keywords: *Altruism ; Economics ; Humans ; Learning ; Models, Psychological ; Politics ; Selection, Genetic ; *Social Behavior
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 14;249(4974):1243.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835531" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guyer, R L -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):731.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759954" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 21;249(4975):1375.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812161" target="_blank"〉PubMed〈/a〉
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  • 27
    Publication Date: 1990-02-23
    Description: Learning an input-output mapping from a set of examples, of the type that many neural networks have been constructed to perform, can be regarded as synthesizing an approximation of a multidimensional function (that is, solving the problem of hypersurface reconstruction). From this point of view, this form of learning is closely related to classical approximation techniques, such as generalized splines and regularization theory. A theory is reported that shows the equivalence between regularization and a class of three-layer networks called regularization networks or hyper basis functions. These networks are not only equivalent to generalized splines but are also closely related to the classical radial basis functions used for interpolation tasks and to several pattern recognition and neural network algorithms. They also have an interesting interpretation in terms of prototypes that are synthesized and optimally combined during the learning stage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poggio, T -- Girosi, F -- New York, N.Y. -- Science. 1990 Feb 23;247(4945):978-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17776454" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sietmann, R -- New York, N.Y. -- Science. 1990 Apr 6;248(4951):23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843305" target="_blank"〉PubMed〈/a〉
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  • 29
    Publication Date: 1990-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1990 May 11;248(4956):684-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812071" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woese, C R -- New York, N.Y. -- Science. 1990 Feb 16;247(4944):789.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2305249" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Enzymes/genetics ; Nucleic Acids/genetics ; Proteins/genetics
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  • 31
    Publication Date: 1990-06-29
    Description: In Rous sarcoma virus (RSV)-infected chickens, wounding leads to tumor formation with nearly 100% frequency in tissues that would otherwise remain tumor-free. Identifying molecular mediators of this phenomenon should yield important clues to the mechanisms involved in RSV tumorigenesis. Immunohistochemical staining showed that TGF-beta is present locally shortly after wounding, but not unwounded controls. In addition, subcutaneous administration of recombinant transforming growth factor-beta 1 (TGF-beta 1) could substitute completely for wounding in tumor induction. A treatment protocol of four doses of 800 nanograms of TGF-beta resulted in v-src-expressing tumors with 100% frequency; four doses of only 10 nanograms still led to tumor formation in 80% of the animals. This effect was specific, as other growth factors with suggested roles in wound healing did not elicit the same response. Epidermal growth factor (EGF) or TGF-alpha had no effect, and platelet-derived growth factor (PDGF) or insulin-like growth factor-1 (IGF-1) yielded only occasional tumors after longer latency. TGF-beta release during the wound-healing response may thus be a critical event that creates a conducive environment for RSV tumorigenesis and may act as a cofactor for transformation in this system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sieweke, M H -- Thompson, N L -- Sporn, M B -- Bissell, M J -- New York, N.Y. -- Science. 1990 Jun 29;248(4963):1656-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2163544" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Chickens ; Epidermal Growth Factor/pharmacology ; Humans ; Immunoenzyme Techniques ; Insulin-Like Growth Factor I/pharmacology ; Platelet-Derived Growth Factor/pharmacology ; Recombinant Proteins/pharmacology ; Sarcoma, Avian/complications/*pathology ; Swine ; Transforming Growth Factors/analysis/*pharmacology ; Wound Healing ; Wounds and Injuries/complications/*pathology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 14;249(4974):1243.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835533" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Apr 27;248(4954):436.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17815580" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silvera, I F -- New York, N.Y. -- Science. 1990 Feb 16;247(4944):863.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17746079" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonald, J C -- McDonald, A D -- New York, N.Y. -- Science. 1990 Aug 24;249(4971):844.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2168090" target="_blank"〉PubMed〈/a〉
    Keywords: Asbestos/*adverse effects ; Asbestos, Serpentine ; Cohort Studies ; Humans ; Mesothelioma/*etiology ; Mining ; Occupational Diseases/*etiology
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  • 36
    Publication Date: 1990-05-18
    Description: The 70-kilodalton family of heat shock proteins (Hsp 70) has been implicated in posttranslational protein assembly and translocation. Binding of cytosolic forms of Hsp 70 (Hsp 72,73) with nascent proteins in the normal cell was investigated and found to be transient and adenosine triphosphate (ATP)-dependent. Interaction of Hsp 72,73 with newly synthesized proteins appeared to occur cotranslationally, because nascent polypeptides released prematurely from polysomes in vivo can be isolated in a complex with Hsp 72,73. Moreover, isolation of polysomes from short-term [35S]Met-labeled cells (pulsed) revealed that Hsp 72,73 associated with nascent polypeptide chains. In cells experiencing stress, newly synthesized proteins coimmunoprecipitated with Hsp 72,73; however, in contrast to normal cells, interaction with Hsp 72,73 was not transient. A model consistent with these data suggests that under normal growth conditions, cytosolic Hsp 72,73 interact transiently with nascent polypeptides to facilitate proper folding, and that metabolic stress interferes with these events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beckmann, R P -- Mizzen, L E -- Welch, W J -- GM 33551/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 May 18;248(4957):850-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2188360" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Azetidinecarboxylic Acid/pharmacology ; Cycloheximide/pharmacology ; HeLa Cells/metabolism ; Heat-Shock Proteins/*metabolism ; Humans ; Immunosorbent Techniques ; Macromolecular Substances ; Molecular Weight ; *Protein Biosynthesis ; Protein Conformation ; Protein Processing, Post-Translational ; Proteins/metabolism ; Puromycin/pharmacology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 16;247(4948):1298.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843790" target="_blank"〉PubMed〈/a〉
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  • 38
    Publication Date: 1990-09-21
    Description: Real-time synchrotron diffraction has been used to monitor the phase transformations of highly exothermic, fast self-propagating solid combustion reactions on a subsecond time scale down to 100 milliseconds and in some instances to 10 milliseconds. Three systems were investigated: Ti + C --〉 TiC; Ti + C + xNi --〉 TiC + Ni-Ti alloy; and Al + Ni --〉 AlNi. In all three reactions, the first step was the melting of the metal reactants. Formation of TiC in the first two reactions was completed within 400 milliseconds of the melting of the Ti metal, indicating that the formation of TiC took place during the passage of the combustion wave front. In the Al + Ni reaction, however, passage of the wave front was followed by the appearance and disappearance of at least one intermediate in the afterburn region. The final AlNi was formed some 5 seconds later and exhibited a delayed appearance of the (210) reflection, which tends to support a phase transformation from a disordered AlNi phase at high temperature to an ordered CsCl structure some 20 seconds later. This new experimental approach can be used to study the chemical dynamics of high-temperature solid-state phenomena and to provide the needed database to test various models for solid combustion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, J -- Larson, E M -- Holt, J B -- Waide, P A -- Rupp, B -- Frahm, R -- New York, N.Y. -- Science. 1990 Sep 21;249(4975):1406-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812168" target="_blank"〉PubMed〈/a〉
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  • 39
    Publication Date: 1990-04-27
    Description: Shell-encrusting species of the coral Aulopora and the bryozoan Leioclema changed ecological pgilds and escaped limits imposed by substrate size through mutstic intergrowth during the Early Devonian. Where colonies of these species intergew, they produced upright, arborescent masses consisting of sparsely branched uniserial Aulopora sp. entirely covered, except for calyx openings, by a thin encrustation of Leioclema sp. These interrowts appear to constitute a mutualistic association with benefits induding escape from limited space on the substratum into a higher tier of suspension feeders, as well as more modules per colony. Such mutualism between benthic modular competitors may have developed more readily than assocations between solitary competitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinney, F K -- Broadhead, T W -- Gibson, M A -- New York, N.Y. -- Science. 1990 Apr 27;248(4954):466-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17815596" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singer, M F -- New York, N.Y. -- Science. 1990 May 18;248(4957):795.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2343298" target="_blank"〉PubMed〈/a〉
    Keywords: *Administrative Personnel ; Budgets ; National Institutes of Health (U.S.)/*organization & administration ; Politics ; Salaries and Fringe Benefits ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guyer, R L -- New York, N.Y. -- Science. 1990 Sep 21;249(4975):1355.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812149" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 16;247(4948):1298.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843789" target="_blank"〉PubMed〈/a〉
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  • 43
    Publication Date: 1990-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1990 Mar 9;247(4947):1177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17809260" target="_blank"〉PubMed〈/a〉
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  • 44
    Publication Date: 1990-04-20
    Description: The earth's mantle is degassed along mid-ocean ridges, while rehydration and possibly recarbonaton occurs at subduction zones. These processes and the speciation of C-H-O fluids in the mantle are related to the oxidation state of mantle peridotite. Peridotite xenoliths from continental localities exhibit an oxygen fugacity (fo(2)) range from -1.5 to +1.5 log units relative to the FMQ (fayalite-magnetite-quartz) buffer. The lowest values are from zones of continental extension. Highly oxidized xenoliths (fo(2) greater than FMQ) come from regions of recent or acive subduction (for example, Ichinomegata, Japan), are commonly amphibole-bearing, and show trace element and isotopic evidence of fluid-rock interaction. Peridotites from ocean ridges are reduced and have an averae fo(2) of about -0.9 log units relative to FMQ, virtually coincident with values obtained from mid-ocean ridge basalt (MORB) glasses. These data are further evidence of the genetic link between MORB liquids and residual peridotite and indicate that the asthenosphere, although reducing, has CO(2) and H(2)O as its major fluid species. Incorporation of oxidized material from subduction zones into the continental lithosphere produces xenoliths that have both asthenospheric and subduction signatures. Fluids in the lithosphere are also dominated by CO(2) and H(2)O, and native C is generally unstable. Although the occurrence of native C (diamond) in deep-seated garnetiferous xenoliths and kimberlites does not require reducing conditions, calculations indicate that high Fe(3+) contents are stabilized in the garnet structure and that fo(2) deareases with increasing depth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wood, B J -- Bryndzia, L T -- Johnson, K E -- New York, N.Y. -- Science. 1990 Apr 20;248(4953):337-45.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17784487" target="_blank"〉PubMed〈/a〉
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-04-06
    Description: The rate of release of guanine nucleotides from the ras proteins (Ras) is extremely slow in the presence of Mg2+. It seemed likely, therefore that a factor might exist to accelerate the release of guanosine diphosphate (GDP), and hence the exchange of GDP for guanosine triphosphate (GTP). Such a factor has now been discovered in rat brain cytosol. Brain cytosol was found to catalyze, by orders of magnitude, the release of guanine nucleotides from recombinant v-H-Ras protein bound with [alpha-32P]GDP. This effect occurred even in the presence of a large excess of Mg2+, but was destroyed by heat or by incubation of the cytosol for an hour at 37 degrees C in the absence of phosphatase inhibitors. The effect was observed with either v-H-Ras or c-H-Ras, but not with p25rab3A, a small G protein with about 30% similarity to Ras. The effect could not be mimicked by addition of recombinant Ras-GAP or purified GEF, a guanine nucleotide exchange factor involved in the regulation of eukaryotic protein synthesis. By gel filtration chromatography, the factor appears to possess a molecular size between 100,000 and 160,000 daltons. This protein (Ras-guanine nucleotide-releasing factor, or Ras-GRF) may be involved in the activation of p21ras.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfman, A -- Macara, I G -- CA 43551/CA/NCI NIH HHS/ -- ES 01247/ES/NIEHS NIH HHS/ -- GM 41220/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Apr 6;248(4951):67-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biophysics, University of Rochester Medical Center, NY 14642.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2181667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Brain/metabolism ; Cholic Acids ; Cytosol/*metabolism ; Guanine Nucleotides/*metabolism ; Guanosine 5'-O-(3-Thiotriphosphate) ; Guanosine Diphosphate/*metabolism ; Guanosine Triphosphate/analogs & derivatives/metabolism ; Hot Temperature ; Immunosorbent Techniques ; Kinetics ; Magnesium Chloride/pharmacology ; Molecular Weight ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins p21(ras) ; Rats ; Thionucleotides/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCauley, C -- New York, N.Y. -- Science. 1990 Apr 27;248(4954):423.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17815573" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 23;247(4949):1414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17791200" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 23;247(4949):1410.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17791197" target="_blank"〉PubMed〈/a〉
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  • 49
    Publication Date: 1990-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1990 Feb 23;247(4945):916.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17776438" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Mar 9;247(4947):1176.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2315692" target="_blank"〉PubMed〈/a〉
    Keywords: *Administrative Personnel ; National Institutes of Health (U.S.)/*organization & administration ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guyer, R L -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):603.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831933" target="_blank"〉PubMed〈/a〉
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  • 52
    Publication Date: 1990-12-07
    Description: The western equatorial Pacific warm pool (sea-surface temperatures 〉29 degrees C) was observed to migrate eastward across the date line during the 1986-1987 El Nino-Southern Oscillation event. Direct velocity measurements made in the upper ocean from 1986 to 1988 indicate that this migration was associated with a prolonged reversal in the South Equatorial Current forced by a large-scale relaxation ofthe trade winds. The data suggest that wind-forced zonal advection plays an important role in the thermodynamics of the western Pacific warm pool on interannual time scales.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McPhaden, M J -- Picaut, J -- New York, N.Y. -- Science. 1990 Dec 7;250(4986):1385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17754983" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beering, S C -- Rosenzweig, R M -- New York, N.Y. -- Science. 1990 Jul 6;249(4964):10-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17787601" target="_blank"〉PubMed〈/a〉
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  • 54
    Publication Date: 1990-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinney, M L -- New York, N.Y. -- Science. 1990 Jan 26;247(4941):475-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17788615" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 7;249(4973):1171-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831994" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Worledge, D H -- New York, N.Y. -- Science. 1990 Aug 3;249(4968):463-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17735266" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skerrett, P J -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1248.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2119053" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus, Experimental/*surgery ; Graft Enhancement, Immunologic ; Immune Tolerance ; *Islets of Langerhans Transplantation ; Rats ; T-Lymphocytes/immunology ; Thymus Gland/surgery ; Transplantation, Heterotopic
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  • 58
    Publication Date: 1990-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1990 Nov 30;250(4985):1207-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17829205" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Mar 23;247(4949):1410-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17791196" target="_blank"〉PubMed〈/a〉
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  • 60
    Publication Date: 1990-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):754-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759966" target="_blank"〉PubMed〈/a〉
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  • 61
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-01-12
    Description: Ideas about quantized energy levels originated in atomic physics, but research in superconductivity has led to unparalleled precision in the measurement of energy levels. A comparison of levels produced by two Josephson junctions shows that they differ by no more than 3 parts in 10(19) at an energy of 0.0003 electron volt. The fact that the myriad of interactions of 10(12) particles in a macroscopic body, a Josephson junction, can produce sharply defined energy levels suggests a dynamical state effectively divorced from the complexities of its environment. The existence of this state, the macroscopic quantum state of superconductors, is well established, but its isolation from intrinsic perturbations has recently been shown to be extraordinary. These new results, with an improved precision of about ten orders of magnitude, are discussed in the context of highly accurate results from quantum electrodynamics, atomic spectroscopy, and the standards of metrology. Further refinements in precision may be achievable at higher energy levels, about 12 electron volts, as they become available from a new series array of 18,992 Josephson junctions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonald, D G -- New York, N.Y. -- Science. 1990 Jan 12;247(4939):177-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17813283" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Mar 23;247(4949 Pt 1):1405.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2321005" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Hospitals ; Hospitals, Proprietary/*economics ; Hospitals, Psychiatric/*economics ; Hospitals, Teaching/*economics ; Hospitals, University/*economics ; Organizational Affiliation/*economics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, K -- New York, N.Y. -- Science. 1990 May 11;248(4956):682-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2333519" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Animals ; HIV/isolation & purification/pathogenicity ; Humans ; Liver/microbiology ; Mycoplasma/*isolation & purification/pathogenicity ; National Institutes of Health (U.S.) ; Research/standards ; Research Design ; United States
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  • 64
    Publication Date: 1990-09-21
    Description: Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-alpha (TNF-alpha). Excess secretion of TNF-alpha causes endotoxic shock, an often fatal complication of infection. LPS in the bloodstream rapidly binds to the serum protein, lipopolysaccharide binding protein (LBP), and cellular responses to physiological levels of LPS are dependent on LBP. CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS. Thus, LPS may induce responses by interacting with a soluble binding protein in serum that then binds the cell surface protein CD14.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, S D -- Ramos, R A -- Tobias, P S -- Ulevitch, R J -- Mathison, J C -- AI 15136/AI/NIAID NIH HHS/ -- AI 22003/AI/NIAID NIH HHS/ -- AI 24775/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1990 Sep 21;249(4975):1431-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1698311" target="_blank"〉PubMed〈/a〉
    Keywords: *Acute-Phase Proteins ; Animals ; Antibodies, Monoclonal/immunology ; Antigens, CD/*immunology ; Antigens, CD14 ; Antigens, CD18 ; Antigens, Differentiation, Myelomonocytic/*immunology ; Carrier Proteins/*immunology ; Erythrocytes/immunology ; Leukocytes/immunology ; Lipopolysaccharides/*immunology ; Macrophages/immunology ; *Membrane Glycoproteins ; Receptors, Leukocyte-Adhesion/immunology ; Sheep ; Tumor Necrosis Factor-alpha/biosynthesis
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 7;249(4973):1103.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831976" target="_blank"〉PubMed〈/a〉
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  • 66
    Publication Date: 1990-06-01
    Description: Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kestler, H -- Kodama, T -- Ringler, D -- Marthas, M -- Pedersen, N -- Lackner, A -- Regier, D -- Sehgal, P -- Daniel, M -- King, N -- AI25328/AI/NIAID NIH HHS/ -- RR00168/RR/NCRR NIH HHS/ -- RR00169/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Jun 1;248(4959):1109-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2160735" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Animals ; Antibodies, Viral/biosynthesis ; Cloning, Molecular ; *Disease Models, Animal ; Leukocytes, Mononuclear/microbiology ; Macaca mulatta ; Macrophages/microbiology ; Opportunistic Infections/etiology ; *Retroviridae Infections/complications/immunology ; *Simian Immunodeficiency Virus/genetics/immunology/isolation & ; purification/pathogenicity ; Transfection ; Virus Replication
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 7;249(4973):1184.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831999" target="_blank"〉PubMed〈/a〉
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  • 68
    Publication Date: 1990-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1990 Oct 26;250(4980):510-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17751478" target="_blank"〉PubMed〈/a〉
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  • 69
    Publication Date: 1990-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woodruff, D P -- New York, N.Y. -- Science. 1990 Jun 1;248(4959):1131.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17733379" target="_blank"〉PubMed〈/a〉
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  • 70
    Publication Date: 1990-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):527-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17743982" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Mar 2;247(4946):1027.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17800050" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wortman, P M -- New York, N.Y. -- Science. 1990 Oct 26;250(4980):493-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17751465" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sinsheimer, R L -- New York, N.Y. -- Science. 1990 Sep 21;249(4975):1359.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2402630" target="_blank"〉PubMed〈/a〉
    Keywords: *Human Genome Project ; Humans ; National Institutes of Health (U.S.) ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Sep 7;249(4973):1170.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831993" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1990 Jan 19;247(4940):282.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17735832" target="_blank"〉PubMed〈/a〉
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1990 Oct 5;250(4977):23-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2218509" target="_blank"〉PubMed〈/a〉
    Keywords: *Electromagnetic Phenomena ; *Environmental Exposure ; Humans ; National Institutes of Health (U.S.) ; Neoplasms/*etiology ; United States ; United States Environmental Protection Agency
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1990 Mar 2;247(4946):1026.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17800047" target="_blank"〉PubMed〈/a〉
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, K -- New York, N.Y. -- Science. 1990 Dec 21;250(4988):1659.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2270478" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/diagnosis/*genetics/prevention & control ; Female ; Humans ; Risk Factors
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  • 79
    Publication Date: 1990-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1990 Jul 6;249(4964):27-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17787621" target="_blank"〉PubMed〈/a〉
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guyer, R L -- New York, N.Y. -- Science. 1990 Jun 15;248(4961):1271.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17747505" target="_blank"〉PubMed〈/a〉
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  • 81
    Publication Date: 1990-07-06
    Description: Oligonucleotides equipped with EDTA-Fe can bind specifically to duplex DNA by triple-helix formation and produce double-strand cleavage at binding sites greater than 12 base pairs in size. To demonstrate that oligonucleotide-directed triple-helix formation is a viable chemical approach for the site-specific cleavage of large genomic DNA, an oligonucleotide with EDTA-Fe at the 5' and 3' ends was targeted to a 20-base pair sequence in the 340-kilobase pair chromosome III of Saccharomyces cerevisiae. Double-strand cleavage products of the correct size and location were observed, indicating that the oligonucleotide bound and cleaved the target site among almost 14 megabase pairs of DNA. Because oligonucleotide-directed triple-helix formation has the potential to be a general solution for DNA recognition, this result has implications for physical mapping of chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strobel, S A -- Dervan, P B -- GM 42966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Jul 6;249(4964):73-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2195655" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Binding Sites ; Chromosomes, Fungal/*metabolism ; DNA, Fungal/*genetics/metabolism ; Densitometry ; Hydrogen-Ion Concentration ; Molecular Sequence Data ; Nucleic Acid Conformation ; Nucleic Acid Hybridization ; Oligonucleotides/*genetics/metabolism ; Saccharomyces cerevisiae/*genetics
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  • 82
    Publication Date: 1990-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Douglas, B C -- Cheney, R E -- Miller, L -- Agreen, R W -- Carter, W E -- Robertson, D S -- New York, N.Y. -- Science. 1990 Apr 20;248(4953):288.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17784470" target="_blank"〉PubMed〈/a〉
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamilton, D P -- New York, N.Y. -- Science. 1990 Nov 2;250(4981):618.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17810851" target="_blank"〉PubMed〈/a〉
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉R, L -- New York, N.Y. -- Science. 1990 Jul 20;249(4966):237.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17750094" target="_blank"〉PubMed〈/a〉
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-30
    Description: The emerging technology of soft x-ray lasers has novel applications to microscopy, lithography, and other fields. This article describes the status of soft x-ray laser research with the aim of bringing the rapid developments in this field to the attention of potential users in other disciplines. The different techniques for generating a population inversion and producing a soft x-ray laser are reviewed. The status of current research in the field and the near-term prospects are described. It is expected that the range of potential applications of soft x-ray lasers will increase as their performance improves. Work aimed at increasing the output power and progressing to shorter wavelengths with these devices is also reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suckewer, S -- Skinner, C H -- New York, N.Y. -- Science. 1990 Mar 30;247(4950):1553-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Princeton University Plasma Physics Laboratory, NJ 08543.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2321016" target="_blank"〉PubMed〈/a〉
    Keywords: HeLa Cells/ultrastructure ; Humans ; *Lasers ; Microscopy/*instrumentation ; Microscopy, Electron, Scanning ; X-Rays
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  • 86
    Publication Date: 1990-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, T E -- New York, N.Y. -- Science. 1990 Apr 6;248(4951):89-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843325" target="_blank"〉PubMed〈/a〉
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  • 87
    Publication Date: 1990-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krauss, L M -- New York, N.Y. -- Science. 1990 Jan 5;247(4938):92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17749496" target="_blank"〉PubMed〈/a〉
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Feb 16;247(4944):810.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17746069" target="_blank"〉PubMed〈/a〉
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-10-19
    Description: Impact craters on Triton are scarce owing to the relatively recent resurfacing by icy melts. The most heavily cratered surface has a crater density about the same as the lunar maria. The transition diameter from simple to complex craters occurs at a diameter of about 11 kilometers, and the depth-diameter relationship is similar to that of other icy satellites when gravity is taken into account. The crater size-frequency distribution has a differential -3 slope (cumulative -2 slope) and is the same as that for the fresh crater population on Miranda. The most heavily cratered region is on the leading hemisphere in Triton's orbit. Triton may have a leading-trailing asymmetry in its crater population. Based primarily on the similarity of size distributions on Triton and Miranda and the relatively young surface on Triton, the source of Triton's craters is probably comets. The very peculiar size distribution of sharp craters on the "cantaloupe" terrain and other evidence suggests they are volcanic explosion craters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strom, R G -- Croft, S K -- Boyce, J M -- New York, N.Y. -- Science. 1990 Oct 19;250(4979):437-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17793023" target="_blank"〉PubMed〈/a〉
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moffat, A S -- New York, N.Y. -- Science. 1990 Jun 22;248(4962):1480.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17818295" target="_blank"〉PubMed〈/a〉
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  • 91
    Publication Date: 1990-05-18
    Description: Monochromatic images of Mercury at the sodium D(2) emission line showed excess sodium emission in localized regions at high northern and southern latitudes and day-to-day global variations in the distribution of sodium emission. These phenomena support the suggestion that magnetospheric effects could be the cause. Sputtering of surface minerals could produce sodium vapor in polar regions during magnetic substorms, when magnetospheric ions directly impact the surface. Another important process may be the transport of sodium ions along magnetic field lines toward polar regions, where they impact directly on the surface of Mercury and are neutralized to regenerate neutral sodium atoms. Day-to-day variations in planetary sodium distributions could result from changing solar activity, which can change the magnetosphere in time scales of a few hours. Observations of the sodium exosphere may provide a tool for remote monitoring of the magnetosphere of Mercury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Potter, A E -- Morgan, T H -- New York, N.Y. -- Science. 1990 May 18;248(4957):835-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17811832" target="_blank"〉PubMed〈/a〉
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamilton, D P -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1249.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835537" target="_blank"〉PubMed〈/a〉
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1990 Aug 3;249(4968):468-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2382125" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Delivery of Health Care/economics/*organization & administration ; Health Services/economics ; *Health Services Administration ; Humans ; Oregon ; United States
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Feb 9;247(4943):633.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17771874" target="_blank"〉PubMed〈/a〉
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  • 95
    Publication Date: 1990-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rainger, R -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):840-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759978" target="_blank"〉PubMed〈/a〉
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-05-18
    Description: Personal injury law is staggeringly inefficient as a system of victim compensation. There is little reason to assume that it importantly curtails unreasonably dangerous conduct, yet there is good reason to conclude that it promotes socially undesirable behavior. Moreover, the tort law system ill serves the goal of individual justice, in part because it assumes that lay juries can correctly decide complex scientific issues. Several methods of replacing tort law with other compensation systems are surveyed and a specific, balanced reform package is proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sugarman, S D -- New York, N.Y. -- Science. 1990 May 18;248(4957):823-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2343303" target="_blank"〉PubMed〈/a〉
    Keywords: Accidents/economics/*legislation & jurisprudence ; Behavior ; Consumer Product Safety/legislation & jurisprudence ; Expert Testimony ; Humans ; Insurance, Liability/economics ; Malpractice/legislation & jurisprudence ; United States
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  • 97
    Publication Date: 1990-01-05
    Description: Radiometric measurements during the past decade from the Solar Maximum Mission and Nimbus 7 satellites have shown that the total solar irradiance varies in step with the sun's 11-year magnetic activity cycle. Stellar observations from the Lowell and Mount Wilson observatories now confirm and elaborate this discovery. These measurements show that older stars similar to the sun tend to become brighter as their magnetic activity level increases, just as the sun does during its 11-year activity cycle. Younger stars, however, tend to become fainter as their magnetic activity level increases. This contrasting behavior suggests that the balance between the competing phenomena that influence solar brightness variability has shifted during the sun's lifetime.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Radick, R R -- Lockwood, G W -- Baliunas, S L -- New York, N.Y. -- Science. 1990 Jan 5;247(4938):39-44.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17749490" target="_blank"〉PubMed〈/a〉
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1990 Feb 9;247(4943):633.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17771876" target="_blank"〉PubMed〈/a〉
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  • 99
    Publication Date: 1990-11-02
    Description: Voltage-gated sodium channels are transmembrane proteins of approximately 2000 amino acids and consist of four homologous domains (I through IV). In current topographical models, domains III and IV are linked by a highly conserved cytoplasmic sequence of amino acids. Disruptions of the III-IV linker by cleavage or antibody binding slow inactivation, the depolarization-induced closed state characteristic of sodium channels. This linker might be the positively charged "ball" that is thought to cause inactivation by occluding the open channel. Therefore, groups of two or three contiguous lysines were neutralized or a glutamate was substituted for an arginine in the III-IV linker of type III rat brain sodium channels. In all cases, inactivation occurred more rapidly rather than more slowly, contrary to predictions. Furthermore, activation was delayed in the arginine to glutamate mutation. Hence, the III-IV linker does not simply act as a charged blocker of the channel but instead influences all aspects of sodium channel gating.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moorman, J R -- Kirsch, G E -- Brown, A M -- Joho, R H -- HL-36930/HL/NHLBI NIH HHS/ -- KL-01858/PHS HHS/ -- NS-23877/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1990 Nov 2;250(4981):688-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Texas Medical Branch, Galveston 77550.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2173138" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Cytoplasm/physiology ; Molecular Sequence Data ; *Mutation ; RNA, Messenger/analysis ; Sodium Channels/chemistry/genetics/*physiology ; Structure-Activity Relationship
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  • 100
    Publication Date: 1990-11-09
    Description: The regulation of DNA replication during the eukaryotic cell cycle was studied in a system where cell free replication of simian virus 40 (SV40) DNA was used as a model for chromosome replication. A factor, RF-S, was partially purified from human S phase cells based on its ability to activate DNA replication in extracts from G1 cells. RF-S contained a human homologue of the Schizosaccharomyces pombe p34cdc2 kinase, and this kinase was necessary for RF-S activity. The limiting step in activation of the p34 kinase at the G1 to S transition may be its association with a cyclin since addition of cyclin A to a G1 extract was sufficient to start DNA replication. These observations suggest that the role of p34cdc2 in controlling the start of DNA synthesis has been conserved in evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉D'Urso, G -- Marraccino, R L -- Marshak, D R -- Roberts, J M -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):786-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2173140" target="_blank"〉PubMed〈/a〉
    Keywords: Burkitt Lymphoma ; CDC2 Protein Kinase/genetics/*physiology ; *Cell Cycle ; Cyclins/pharmacology ; *DNA Replication ; Humans ; Interphase ; Phosphorylation ; Schizosaccharomyces/enzymology ; Simian virus 40/*genetics/physiology ; Tumor Cells, Cultured ; *Virus Replication
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