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  • 1
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    Human sleep: its duration and organization depend on its circadian phase (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleep episodes was highly correlated with the circadian phase of the body temperature rhythm at bedtime and not with the length of prior wakefulness. Furthermore, the rate of REM (rapid eye movement) sleep accumulation , REM latency, bedtime selection, and self-rated alertness assessments were also correlated with the body temperature rhythm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Weitzman, E d -- Moore-Ede, M C -- Zimmerman, J C -- Knauer, R S -- AG-00792/AG/NIA NIH HHS/ -- GM-07365/GM/NIGMS NIH HHS/ -- MH-28460/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1264-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434029" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Body Temperature ; *Circadian Rhythm ; Humans ; Male ; Middle Aged ; Sleep/*physiology ; Sleep, REM/physiology ; Wakefulness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Amino acid acylation: a mechanism of nitrogen excretion in inborn errors of urea synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Treatment of a patient deficient in carbamyl phosphate synthetase with benzoate or phenylacetic acid resulted in an increase in urinary nitrogen, which could be accounted for by the respective amino acid acylation product, hippurate or phenylacetylgultamine. Benzoate treatment of four hyperammonemic comatose patients led to clinical improvement and a return of plasma ammonium levels toward normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brusilow, S -- Tinker, J -- Batshaw, M L -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243418" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Amino Acid Metabolism, Inborn Errors/*drug therapy ; Amino Acids/blood ; Ammonia/blood ; Benzoates/*therapeutic use ; Carbamoyl-Phosphate Synthase (Ammonia)/*deficiency ; Child ; Female ; Glutamine/metabolism ; Glycine/metabolism ; Hippurates/urine ; Humans ; Infant ; Male ; Nitrogen/blood ; *Ornithine Carbamoyltransferase Deficiency Disease ; Phenylacetates/*therapeutic use ; Phosphotransferases/*deficiency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Whale meat in the Japanese diet (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownell, R L Jr -- Omura, H -- New York, N.Y. -- Science. 1980 May 30;208(4447):976.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189604" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Japan ; Meat/*analysis ; Organomercury Compounds/*analysis ; Whales
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Attentional factors in the inhibition of a reflex by a visual stimulus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: A brief stimulus presented to various regions of the visual field inhibited the eyeblink elicited by a subsequent tap to the skin between the eyebrows. Subjects were able to switch their attention toward or away from the target area without moving their eyes. In doing so they changed the amount of inhibition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DelPezzo, E M -- Hoffman, H S -- HD 10511-07/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):673-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433993" target="_blank"〉PubMed〈/a〉
    Keywords: *Attention ; Humans ; Reflex/*physiology ; Visual Fields ; Visual Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    N-acetylglucosamine-6-sulfate sulfatase deficiency reconsidered (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Di Ferrante, N -- New York, N.Y. -- Science. 1980 Oct;210(4468):448.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6776626" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Mucopolysaccharidoses/*enzymology ; Sulfatases/*deficiency/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: Newborn infants, chronically exposed in utero to low doses of methadone with or without concomitant heroin, display more rapid eye movement sleep and less quiet sleep than control infants, while babies fetally exposed to both opiates and nonopiates have less organization of sleep states. Other perinatal factors, such as birth weight and gestational age, are related more to the amount of fetal drug exposure than to the type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dinges, D F -- Davis, M M -- Glass, P -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):619-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190326" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Weight ; Female ; Heroin/*adverse effects ; Heroin Dependence/drug therapy ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/*chemically induced ; Maternal-Fetal Exchange ; Methadone/*adverse effects/therapeutic use ; Nervous System Diseases/*chemically induced ; Pregnancy ; Sleep/*drug effects ; Substance-Related Disorders
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Collagen: molecular diversity in the body's protein scaffold (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: Intensive research in the last decade has revealed a wealth of detail on the mechanism of biosynthesis, molecular structure, and covalent cross-linking of collagen. Tissues of higher animals express a family of at least five genetically distinct types of collagen molecule, each apparently tailored for different construction work outside the cell. Within each genetic type of collagen, further chemical heterogeneity is also evident; the variations in hydroxylation, glycosylation, and cross-linking are dependent, for example, on tissue type, age, and hormonal status. The functional significance of collagen's molecular diversity and its control by different cells and tissues are not yet well understood but abnormalities of collagen in many human diseases keep this protein a focal molecule of medical research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eyre, D R -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1315-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355290" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Calcification, Physiologic ; Cartilage/ultrastructure ; *Collagen/genetics/metabolism ; Epithelium/ultrastructure ; Extracellular Space/ultrastructure ; Humans ; Hydrogen Bonding ; Polymorphism, Genetic ; Protein Biosynthesis ; Protein Conformation ; Vertebrates
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Three-dimensional molecular modeling and drug design (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: A discussion of drug-receptor theory is used to show that the three-dimensional structure, or shape, of molecules is important for biological activity. The computer-assisted molecular modeling system at Merck is described, and it is shown that this system is useful for generating and storing molecular structures, determining preferred conformation, comparing molecular shapes, and computing molecular properties. Applications of the system to the study of anti-inflammatory drugs, somatostatin-like compounds, and dihydrofolate reductase inhibitors are summarized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gund, P -- Andose, J D -- Rhodes, J B -- Smith, G M -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1425-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6104357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids ; Binding Sites ; Computers ; Cyclooxygenase Inhibitors ; Humans ; Indomethacin ; *Models, Molecular ; *Models, Structural ; *Molecular Conformation ; *Pharmaceutical Preparations ; Receptors, Drug/metabolism ; Somatostatin/analogs & derivatives ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-14
    Description: Infrequent, attended, auditory and visual stimuli evoke large potentials in the human limbic system in tasks that usually evoke endogenous potentials at the scalp. The limbic potentials reverse polarity over small distances and correlate with unit discharges recorded by the same electrodes, indicating that they are locally generated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halgren, E -- Squires, N K -- Wilson, C L -- Rohrbaugh, J W -- Babb, T L -- Crandall, P H -- NS02808/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 14;210(4471):803-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434000" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*physiology ; Auditory Perception/physiology ; Cognition/physiology ; Evoked Potentials ; Hippocampus/*physiology ; Humans ; Membrane Potentials ; Visual Perception/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Holographic assessment of microwave hearing (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou, C K -- Guy, A W -- Foster, K R -- Galambos, R -- Justesen, D R -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1143-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403877" target="_blank"〉PubMed〈/a〉
    Keywords: *Hearing ; *Holography ; Humans ; *Microwaves
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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