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  • Nature Publishing Company
  • 1990-1994  (1,972)
  • 1980-1984  (562)
  • 1
    Electronic Resource
    Electronic Resource
    Comments (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 417-418 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The following offers a fuller description of fermentor and bioreactor product lines, including information on the equipment type (Equip.), sterilization options (Ster.), type of aeration (Aer), impeller selection (Impel.), and some information on computer interfaces and other options available ...
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    URL: http://dx.doi.org/10.1038/nbt0590-417
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  • 2
    Electronic Resource
    Electronic Resource
    Horses in Mid-Stream (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 269-269 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] I do not allow myself to suppose that [anyone has] concluded to decide that I am either the greatest or best man in America, but rather they have concluded that it is not best to swap horses while crossing the river, and have further concluded that I am not so poor a horse that they might not make ...
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    URL: http://dx.doi.org/10.1038/nbt0490-269
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  • 3
    Electronic Resource
    Electronic Resource
    Bovine Alpha S1 -Casein Gene Sequences Direct High Level Expression of Active Human Urokinase in Mouse Milk (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 443-446 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have produced a line of transgenic mice carrying a hybrid bovine αs1 casein/human urokinase gene. Bovine αs1-casein gene regulatory sequences specifically direct expression of the human urokinase gene in lactating mammary tissue from these mice. Urokinase is a 54 kD protein with 9 ...
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    URL: http://dx.doi.org/10.1038/nbt0590-443
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  • 4
    Electronic Resource
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    Wolffish Antifreeze Protein from Transgenic Drosophila (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 453-457 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have expressed two antifreeze protein genes from the Atlantic wolffish, Anarhichas lupus, in Drosophila melanogaster by placing them under the divergent transcriptional control of the host yolk poly-peptide (1 and 2) gene promoters. Both genes were joined to the central promoter region by fusion ...
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    URL: http://dx.doi.org/10.1038/nbt0590-453
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  • 5
    Electronic Resource
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    Blotting and Hybridization Tools (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 467-467 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Non-Radioactive RNA Labeling The Genius™ kit from Boehringer Mannheim Biochemicals (Indianapolis, IN) provides reagents for labeling RNA with the steroid hapten digoxigenin. RNA probes, labeled using SP6 or T7 polymerase-catalyzed in vitro transcription reactions, can be used in Northern, ...
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    URL: http://dx.doi.org/10.1038/nbt0590-467
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  • 6
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    Nucleic Acid and Protein Blotting (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 465-466 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Though PCR has stolen the limelight during the last few years, Southern blotting and its corollaries remain a universal tool for examining gene structure and expression. Techniques for assaying nucleic acid by solid-state hybridizations, developed by Ed Southern in the '70s, are firmly entrenched ...
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    URL: http://dx.doi.org/10.1038/nbt0590-465
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  • 7
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    Amplifying Genes: PCR and Its Alternatives (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 291-294 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Aptly nicknamed the “people's choice reaction, ” PCR has become one of the most enabling technologies around. The polymerase chain reaction, which glories in amplifying small amounts of DNA—and rapidly—has been put to use to identify criminals, study the population genetics ...
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    URL: http://dx.doi.org/10.1038/nbt0490-291
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  • 8
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    Announcements (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 581-581 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] July 1-5. Stability of Proteins—Theory & Practice. Cambridge, U.K. Info: S. Mathias, PafraLtd.,BiopreservationDiv., 150 Science Park, Milton Rd., Cambridge CB4 4GG, U.K. July 5-7. 3rd Int'l. Symp. on Delivery of Peptide Drugs. Amsterdam, The Netherlands. Info: H.A.H. Nauta, Centre for ...
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    URL: http://dx.doi.org/10.1038/nbt0691-581
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  • 9
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    COBIOTECH: ICSU's Focus on Biotechnology (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 480-480 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Curious or skeptical friends often ask, “What and why is COBIOTECH? What is it doing?” After serving as president during its formative years, I attempt here to describe this organization's emerging role in biotechnolo gy internationally. COBIOTECH is the acronym of the Committee for ...
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    URL: http://dx.doi.org/10.1038/nbt0590-480
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  • 10
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    Bio-Biz Quiz (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 401-401 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Minor poets imitate; Great poets steal,” said T. S. Eliot in his Essays in Criticism. In this case, though, the stolen items are not couplets but questions—a quiz constructed for the audience at the Paine Webber Bio/Technology Conference by PaineWebber pharmaceutical-industry analyst ...
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    URL: http://dx.doi.org/10.1038/nbt0591-401
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  • 11
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    Transgenic Sciences Making a Big Splash (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 279-279 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] FT. LAUDERDALE, Fla.—When a company goes public in May and nets $2 million, then makes a $7.5 million acquisition the following December, people take notice. People also take notice when a fledgling biotech company in one of the more exotic market segments says it anticipates ...
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    URL: http://dx.doi.org/10.1038/nbt0490-279a
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  • 12
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    New Products (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 351-355 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Perfusion Reactor With a range of working volumes from 3.5–1,000 liters, the Spinferm perfusion reactor from MBR Bioreactor AG (Wetzikon, Switzerland) provides conditions suitable for the culture of fragile mammalian and plant cells. The steam-sterilizable unit supports cultures to densities ...
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    URL: http://dx.doi.org/10.1038/nbt0490-351
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  • 13
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    Environmentalists Carp About Planned Test (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 286-286 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Plans by researchers at Auburn University (Auburn, AL) to test genetically engineered carp in outdoor ponds will have “no significant impact on the quality of the human environment,” according to a U.S. Department of Agriculture (USDA) review. Critics disagree ...
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    URL: http://dx.doi.org/10.1038/nbt0490-286a
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  • 14
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    Can These Corporate Cultures Coalesce? (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 286-286 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] BASEL, Switzerland—The headquarters buildings of Hoffmann-La Roche are nestled along the swiftly-running headwaters of the Rhine in prosperous-looking surroundings—a far cry from the rough-and-tumble warehouse and small-factory district of South San Francisco that Genentech calls home. ...
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    URL: http://dx.doi.org/10.1038/nbt0490-286b
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  • 15
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    The Realities and Challenges of Plant Biotechnology (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 296-301 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plant biotechnology has often been touted overzealously and prematurely as a cure-all for many agricultural problems, and a panacea for the genetic manipulation and improvement of plants2. There has been a great deal of hype and rhetoric, but little substance. This general lack of objectivity, ...
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    URL: http://dx.doi.org/10.1038/nbt0490-296
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  • 16
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    Antisense Start-Ups Surveyed (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 303-304 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Some of the hot new biotech start-ups just don't make any sense. In fact, they're de signed around making “anti-sense” compounds to block gene expression and ultimately, perhaps, provide a new wave of biotechnologi-cally derived therapeutics. The idea is relatively simple: Instead of ...
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    URL: http://dx.doi.org/10.1038/nbt0490-303
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  • 17
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    Quantitative Flow Measurements in Bioreactors by Nuclear Magnetic Resonance Imaging (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 327-330 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed nuclear magnetic resonance (NMR) flow imaging techniques to measure fluid flow in a cell-free hollow fiber bioreactor (HFBR). Using 1H NMR we track the motion of protons and obtain velocity distributions as a function of position and time. These measurements enable the ...
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    URL: http://dx.doi.org/10.1038/nbt0490-327
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  • 18
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    Gel Microdroplets and Flow Cytometry: Rapid Determination of Antibody Secretion by Individual Cells Within a Cell Population (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 333-337 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We report a new method capable of rapidly determining the secretion of biologically important macromolecules from each of many individual cells within a large population. This method combines flow cytometry with gel microdroplets (GMDs), which in this study were agarose particles ranging from about ...
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    URL: http://dx.doi.org/10.1038/nbt0490-333
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  • 19
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    Expression and Secretion of a Functional Scorpion Insecticidal Toxin in Cultured Mouse Cells (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 339-342 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have expressed a synthetic gene encoding the insecticidal neurotoxin of scorpion Androctonus australis (AaIT) in NIH/3T3 mouse fibroblast cells under the transcriptional control of a murine retro-viral long terminal repeat. The secretion of the toxin into the culture medium was directed by the ...
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    URL: http://dx.doi.org/10.1038/ng0490-339
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  • 20
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    Japan Roundup (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 188-188 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Chiba University (Chiba) Department of Pharmacy researchers I. Murakoshi and K. Saito have used Agrobacterium-mediated transformation to introduce heterogeneous genes into medicinal plants, including daylily, cardiotonic Digitalis, and belladonna. At this stage, the scientists have transferred ...
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    URL: http://dx.doi.org/10.1038/nbt0390-188
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  • 21
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    Bioseparations: Media and Modes (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 200-201 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Designers of protein pharmaceutical purification processes havenever been keen on being the first to implement a new method. Entrusted with extracting an injectable-grade product from a primordial soup of cell culture fluids, engineers want safety and reliability. Experimenting with new twists and ...
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    URL: http://dx.doi.org/10.1038/nbt0390-200
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  • 22
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    Production of Correctly Processed Human Serum Albumin in Transgenic Plants (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 217-221 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have used a modified CaMV 35S promoter to direct the expression of chimaeric genes encoding human serum albumin (HSA) in transgenic potato and tobacco plants. To secrete the protein, either the human prepro-sequence or the signal sequence from the extracellular tobacco protein PR-S was used. We ...
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    URL: http://dx.doi.org/10.1038/nbt0390-217
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  • 23
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    Pulsed-Field Separations: Continued Evolution (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 243-245 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It's been crucial to the Human Genome Project,” says Charles Cantor about pulsed-field elec-trophoresis. “[These methods] are still the only way we have to characterize large DNA. Pulsed-field separations have provided the bridge between classical genetics and molecular genetics and ...
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    URL: http://dx.doi.org/10.1038/nbt0390-243
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  • 24
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    Free Literature (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 253-253 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Automated Sample Prep. A new 18-page brochure from Waters Chromatography (Milford, MA) describes its MilliLab™ Workstation, which automates tasks including nitration, solid-phase extraction, liquid/liquid extraction, evaporation, dilution, mixing, and gas purging. Write in 702 on Reader ...
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    URL: http://dx.doi.org/10.1038/nbt0390-253
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  • 25
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    Consider the Source (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 255-255 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The author of “Biotechnology Falls Foul of the Environment in the USSR” (Bio/Technology 7:783, Aug. '89) is right: A powerful move ment of the public at large against the construction of plants for single cell protein production as well as other production facilities ...
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    URL: http://dx.doi.org/10.1038/nbt0390-255b
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  • 26
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    The Genome Information Privacy Act (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 264-264 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Breakthroughs in genetic diagnoses through restriction fragment length polymorphism (RFLP) or linkage analyses in many instances already far exceed our ability to use such information wisely. The legality of compiling an individual's “genetic dossier” has yetto be determined, but is an ...
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    URL: http://dx.doi.org/10.1038/nbt0390-264
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  • 27
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    Scope of U.K. Proposals Widened (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 100-100 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON, U.K.—Scientists proposing to release genetically engineered organisms into the environment soon will be obliged not only to safeguard human health but also to protect the environment from harm. Present arrangements under the Health and Safety at Work Act are designed to minimize ...
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    URL: http://dx.doi.org/10.1038/nbt0290-100
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  • 28
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    Non-Protein Engineering: Small Drug Design (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 105-107 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It only takes one hit to make billions from a drug–but that one hit can cost dearly. In 1989, pharmaceutical companies invested $14 billion in drug development, and came up with the modest reward of 22 new chemical entities. By one estimate, for each new compound that enters the ...
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  • 29
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    Rabbit β-Casein Promoter Directs Secretion of Human Interleukin-2 into the Milk of Transgenic Rabbits (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 140-143 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To test the potential usefulness of transgenic rabbits as production systems for human proteins of pharmaceutical value, we cloned the rabbit β-casein promoter and fused it to the genomic sequence of the human interleukin-2 (hIL2) gene. Four transgenic female rabbits were tested for expression ...
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  • 30
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    Automated Laser-Fluorescence Sequencing (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 147-148 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As sequencing projects get larger and the market for automated instruments continues to grow, more instrument makers are entering themarket, and existing players are up grading their wares. Automated DNA sequencers come with electrophoresis modules, detectors for fluorescent or radioactive labels, ...
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    New Products (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 151-153 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ion-Exchange Cartridges Kinetek Systems (St. Louis, MO) introduces Isonet™ ion-exchange cartridges for purifying proteins. Featuring radial flow geometry for high flow rates and capture efficiencies, the cartridges are an alternative to shallow-bed ion-exchange columns. Two cartridge types ...
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  • 32
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    Concepts in Question Regarding HIV Infection (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 160-160 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The development of therapeutics for human immunodeficiency virus (HIV) infection requires judgments concerning the target patient population under study and the outcome measures which are to be employed. In dealing with these considerations, we have had occasion to note that the collective thinking ...
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  • 33
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    Patenting EPO Analogs: Screening vs. Predictability (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 112-113 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On December 11, 1989, a federal magistrate in Boston issued a decision (Civil Action 87-2617-Y) in the erythropoietin (EPO) lawsuit between Amgen (Thousand Oaks, CA) and Genetics Institute (GI, Cambridge, MA). That decision upheld both U.S. Patent 4,703,008 (Amgen's) and U.S. Patent 4,677,195 ...
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  • 34
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    The Improving Prospects for Yield Increase by Genetic Engineering in Antibiotic-Producing Streptomycetes (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 115-121 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Molecular genetics has spawned a dramatic expansion of the biotechnology industry in the direction of the products of single genes. On the other hand, antibiotics—some of the classical products of biotechnology—result from the concerted action of many genes, and it is therefore less ...
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    ABC and IBA: Appropriate and Inevitable (1991)
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    Nature biotechnology 9 (1991), S. 492-492 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Members and staff of the Association of Biotechnology Companies (ABC) and the Industrial Biotechnology Association (IBA), the two Washington, D.C.-based U.S. biotechnology associations, are often asked “Why two trade groups?” Biotechnology is too small, new, or “product ...
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    Boosting Biocontrol Efforts (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 315-315 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We seldom look back with satisfaction and relief on past failures to develop exciting avenues of research. But those reactions do seem appropriate in the case of some excellent work on the biological control of crop diseases that was carried out at the Experimental Station of Cheshunt in the U.K. ...
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    Genotyping of Bovine Kappa-Casein Loci Following DNA Sequence Amplification (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 144-146 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Caseins are a family of milk proteins that exist in several molecular forms (alphas1, alphas2, beta and kappa) with variant alleles of each. Kappa-caseins (κ-CN) exist as A or B variants and are of particular importance to the quality of the milk. We report a rapid non-radioactive method for ...
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    Products for Sequencing and Synthesis (1990)
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    Nature biotechnology 8 (1990), S. 149-150 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Protein Sequencer The CI 4000 protein sequencer from Chelsea Instruments (London, U.K.) is designed with the inexperi enced user in mind. Fully software driven, it supports sensitive, accurate sequencing and displays program status on-screen during operation, including valve positions and tempera ...
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    Announcements (1990)
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    Nature biotechnology 8 (1990), S. 155-155 
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    Notes: [Auszug] FEBRUARY MEETINGS Feb. 15–20. 1990 AAAS Annual Meeting. New Orleans, LA. Info: AAAS Annual Meeting Registration, PO Box 23320, Alexandria, VA 22304-9330. Feb. 21–23. 1990 Biotechnology Conference for Financial Analysts. Fort Lauderdale, FL. Info: Susan Racca, Industrial Biotechnology ...
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    EPO, Factor VIII Shockers (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 327-327 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Two federal court rulings came down in early March and staggered the biotech community. The U.S. Court of Appeals for the Federal Circuit (CAFC) upheld Amgen's (Thousand Oaks, CA) patent claims to erythropoietin (EPO). But at the same time, the appellate court struck down Genetics ...
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    Freedom Has Its Price (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 87-87 
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    Notes: [Auszug] A few months ago, I was talking to a former Soviet dissident scientist who had left the U.S.S.R. before the era of glasnost to settle in Israel. We discussed Mr. Gorbachev, human rights, religious freedom, and the demise of the Cold War. Then I enquired what had been the major difficulty he had ...
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    Can Antibodies to IgE Act as Anti-Allergics? (1990)
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    Nature biotechnology 8 (1990), S. 96-96 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Immunoglobulin E (IgE)—an otherwise minor component of the immunoglobulin repertoire—mediates most forms of immediate-type hyper-sensitivity, including asthma, by binding to the Fcε receptors on the surfaces of basophils and mast cells. Cross-linking of this IgE by an allergen ...
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    Hoechst Decision Spurs Action (1990)
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    Nature biotechnology 8 (1990), S. 99-99 
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    Notes: [Auszug] LONDON, U.K.—The government of the Federal Republic of Germany has gotten itself into a sticky situation after the decision of the state court of Hessen to prevent Hoechst AG (Frankfurt, F.R.G.) from producing human insulin (Bio/Technology 7:1213, Dec.'89) until a legal framework is in ...
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    High-Level Direct Expression of Semi-Synthetic Human Interleukin-6 in Escherichia coli and Production of N-Terminus Met-Free Product (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 1036-1040 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a direct expression system for high-level production of recombinant human interleukin-6 (rhIL-6) in Escherichia coli. In this system, (i) the natural N-terminal coding region of the hIL-6 gene was replaced by a synthetic sequence containing A-T rich codons, (ii) dual ...
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    New Products (1990)
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    Nature biotechnology 8 (1990), S. 1051-1054 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Hall Fermentor Herzog-Hart (Boston, MA) offers the Hall Fermentor as an improved bioreactor for aerobic fermentations. It features higher oxygen transfer rates than conventional fermentors and lower power consumption. A pilot plant is available for customer trials and process scale-up studies. ...
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    Chilling Predictions (1990)
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    Nature biotechnology 8 (1990), S. 983-983 
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    Notes: [Auszug] In February 1977 New Scientist contributor Duncan Campbell was arrested along with two other people and charged under the U.K.'s Official Secrets Act. The following November all three were committed for trial under Section 1 of the Act—which carries penalties of up to 14 years imprisonment, ...
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    More Changes in U.S. Regulatory Bodies (1990)
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    Nature biotechnology 8 (1990), S. 996-996 
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    Notes: [Auszug] WASHINGTON, B.C.—Determining who's overseeing what in the landscape of U.S. biotechnology policy-makers is like sifting through alphabet soup: The characters seem to be constantly recombining. Officials in the President's Office of Science and Technology Policy (OSTP) recently replaced the ...
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    Researchers Pursue nod Genes' Trigger (1990)
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    Nature biotechnology 8 (1990), S. 897-897 
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    Notes: [Auszug] SWANSEA, U.K.—Discoveries are now beginning to link the genetics and biochemistry of nodulation of soybean, peanuts, and other legumes, Andy Johnston told the Annual Meeting of the British Association for the Advancement of Science. Johnston was speaking in a session on the environmental ...
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    U.S. Field Test Underway, Another Planned (1990)
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    Nature biotechnology 8 (1990), S. 897-897 
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    Notes: [Auszug] WASHINGTON, D.C.—Fighting late-summer heat, humidity, and swarms of insects, a research team coordinated by the Wistar Institute (Philadelphia, PA) recently distributed 3,000 rabies-vaccine-laden baits in rugged upland regions of Parramore Island, Virginia. The coastal island thus became the ...
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    The Year in Review (1990)
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    Nature biotechnology 8 (1990), S. 913-914 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] IS BIOTECHNOLOGY AN INDUSTRY, OR AN AG-gregate of tools and information that drug and chemical manufacturers are waiting to snatch up? Has there been a stratification or a shake-out among the U.S. biotech companies? As products continue to inch toward testing and approval, the business community ...
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    Are B.T.K. Plants Really Safe to Eat? (1990)
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    Nature biotechnology 8 (1990), S. 1011-1015 
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    Notes: [Auszug] Tomatoes were introduced to Europe from Mexico in 1523, and Europeans considered “love apples” ornamental plants for several centuries. Except in Italy, tomato fruit were regarded as poisonous—as in fact, the leaves are. It was not until the mid-1800s that the tomato's image ...
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    Products for Sequencing (1990)
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    Nature biotechnology 8 (1990), S. 1050-1050 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fast UV Crosslinker The Spectrolinker from Spectronics (Westbury, NY) covalently attaches DNA and/or RNA to nitrocellulose or nylon membranes using a precise dose of short-wave (254 nm) ultraviolet light. This can increase hybridization signal sensitivity by an order of magnitude over conventional ...
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    Tryptophan Production Questions Raised (1990)
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    Nature biotechnology 8 (1990), S. 992-992 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, B.C.—Researchers have tentatively traced the cause of eosinophilia-myalgia syndrome (EMS), a rare but sometimes deadly disease affecting blood cells and muscle tissues, to contaminants found in several lots of L-tryptophan. Some of the researchers as well as biotechnology critics, ...
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    Free Literature (1990)
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    Nature biotechnology 8 (1990), S. 1055-1055 
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    Notes: [Auszug] Stains and Indicators. The Sigma-Al-drich Handbook of Stains, Dyes and Indicators from Aldrich (Milwaukee, WI) describes over 500 compounds, including GAS registry and Colour Index numbers, molecular formulae and weight, melting and boiling points, appearance, λmax, solubilities, UV-VIS ...
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    Efficient KEX2-Like Processing of a Glucoamylase-Interleukin-6 Fusion Protein by Aspergillus Nidulans and Secretion of Mature Interleukin-6 (1991)
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    Nature biotechnology 9 (1991), S. 378-381 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have designed an expression vector for the secretion of human interleukin-6 (hIL-6) in which the mature protein is fused through a spacer peptide, contain-ing a KEX-2 like protein processing signal, to the entire Aspergillus niger glucoamylase (glaA) gene. Transformation of Aspergillus nidulans ...
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    Microscopy Products (1991)
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    Nature biotechnology 9 (1991), S. 382-382 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Modular Microscope The Microphot SA, a modularly constructed microscope from Nikon (Melville, NY), is designed for image analysis, photometry, and quantitative video. With dual photo/video ports, it accommodates two photo or video systems simultaneously, including closed-circuit television, ...
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    New Products (1991)
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    Nature biotechnology 9 (1991), S. 383-385 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Capillary Electrophoresis Three CElect™ capillary-electro-phoresis columns with bonded phases are available from Supelco (Belle-fonte, PA). The three phases include a moderately hydrophobic phase, a highly hydrophobic phase, and a hy-drophilic phase. The phases alter electroosmotic flow in ...
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    Free Literature (1991)
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    Nature biotechnology 9 (1991), S. 386-386 
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    Notes: [Auszug] SAF Consortium. Three major suppliers of laboratory chemicals and bio-chemicals have combined to create SAF Bulk Chemicals (Poole, U.K.). Sigma (Poole, U.K.), Alrich (Gillingham, U.K.) and Fluka (Buchs, Switzerland) are the members of the group and will supply gram to ton quantities of standard or ...
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    Who's the Competition in Biotech? (1990)
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    Nature biotechnology 8 (1990), S. 920-922 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Predictions of intense competition for U.S. biotechnology companies are prevalent as these firms plan the introduction of a swell of new products. The congressional Office of Technology Assessment (OTA) and other groups have warned of stiff challenges coming from Japan and Western Europe as ...
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    A Novel Screening System for Yeast Strains Capable of Secreting Tissue Plasminogen Activator (1990)
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    Nature biotechnology 8 (1990), S. 956-958 
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    Notes: [Auszug] We have developed a simple screening procedure that allowed us to identify Saccharomyces cerevisiae strains able to secrete human tissue plasminogen activator (tPA) into the culture medium. The screen can be used to isolate more efficient secre-tor strains and to look for novel tPA analogs. ...
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    Open Approach to Federal Coordination Urged (1990)
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    Nature biotechnology 8 (1990), S. 13-13 
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    Notes: [Auszug] WASHINGTON, D.C.—A high-level federal review committee is suggest ing changes in the way the U.S. gov ernment oversees biotechnology. In a draft report, the Committee on Regu lation of the Administrative Confer ence of the United States (ACUS) recommends that Congress and the President's ...
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    EPO Rights Still Unsettled, Eminase Emerges (1990)
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    Nature biotechnology 8 (1990), S. 8-9 
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    Notes: [Auszug] Embattled infringers. On December 11, Magistrate Patti Saris ruled in Federal District Court in Boston that Amgen (Thousand Oaks, CA) and Genetics Institute (GI, Cambridge, MA) each have infringed claims in the others' patents relating to eryth-ropoietin (EPO). While this may af fect Amgen's right ...
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    U.K. Targets Some Gene-Modified Foods (1991)
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    Nature biotechnology 9 (1991), S. 227-227 
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    Notes: [Auszug] LONDON — British manufacturers are now being asked to label certain foods as products of gene technology. No other European country has yet acted in this way, and labeling is not included in the novel foods directive now being finalized by the European Commission. The new requirements, which ...
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    Downstream Processing: Key To Slashing Production Costs 100 Fold (1991)
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    Nature biotechnology 9 (1991), S. 229-234 
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    Notes: [Auszug] A Herculean task confronted Genentech (So. San Francisco, CA) during development of its production process for tissue plasminogen activator (t-PA). When the company started the process in 1982, t-PA's expected dose was one milligram. But as the drug moved through clinical trials, the dose rose to ...
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    Companies Confront FDA and Demons Within (1991)
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    Nature biotechnology 9 (1991), S. 232-232 
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    Notes: [Auszug] Researchers lowering downstream-processing costs face several obstacles. The biggest is current technology's inability to fully characterize recom-binant proteins. Analytical techniques can completely define the chemical nature of such traditional, low-molecular-weight drugs as penicillin. But ...
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    Peptide Synthesis Gets Friendly (1991)
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    Nature biotechnology 9 (1991), S. 237-241 
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    Notes: [Auszug] Researchers depend on peptides. They are using them as enzyme inhibitors1, as immunogens2, and as potential vaccine candidates3. Peptides are also providing the outline designs for more manageable pharmacological morsels. According to Jean-Marie Sonet, of custom peptide synthesis specialists ...
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    What The U.S. Biopharmaceutical Industry Wants (1991)
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    Nature biotechnology 9 (1991), S. 244-246 
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    Notes: [Auszug] Developers of biopharmaceuticals have unique characteristics that lead to unique public-policy concerns. Firstly, cost-of-capital considerations often dictate strategic planning. Whereas the traditional pharmaceutical industry relies primarily on revenues from existing products to fund its R&D ...
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    FDA: Biotech Friend Or Foe? (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 248-250 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The primary goal of any company—biotechnology or otherwise—is to get a product on the market and start selling it as soon as possible. For U.S. biopharmaceutical companies, the gatekeeper in the approval process is the Food and Drug Administration (PDA, Bethesda, MD). The goals of the ...
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    A New Model For Enzymatic Hydrolysis of Cellulose Based on the Two-Domain Structure of Cellobiohydrolase I (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 286-290 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have studied the kinetics of adsorption to macrocrystalline cellulose (Avicel) and its hydrolysis by intact and isolated domains of Trichoderma reesei cellobiohydrolase I (CBH I). The catalytic domain (the core) shows lower adsorption and activity than the complete enzyme, the effect being more ...
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    It Looks Like Up to Me (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 113-113 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] That time of year…. When yellow leaves, or none, or few, do hang Upon those boughs which shake against the cold, Bare ruin 'd choirs, where late the sweet birds sang. The first weeks of January were full of post-hangover post-mortems. They blow down the streets and flutter in the gutters ...
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    When Past is Prologue (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 115-115 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This is a story of two anniversaries, one a good deal more meritorious than the other, and a nice piece of work by Monsanto which puts both into perspective. First, peer back 50 years to the paper by George Beadle and Edward Tatum in the Proceedings of the National Academy of Sciences (27:499, ...
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    Vector May Help Direct Oxford Virology (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 125-125 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON— A U.K. R&D company with only a dozen employees has established a potentially important product marketing deal with the major scientific center in Siberia. Tiny Oxford Virology (OV, London) has secured the exclusive right to market a large range of research biochemicals and ...
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    Japan Roundup (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 130-130 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Toyota Motor Corp. (Toyota) has budgeted 500 million yen for a new biotechnology research institute, to be headquartered at its technical center. In addition to the ongoing biotechnology research activities at Toyota Central Research and Development Laboratories, the new “Bio Lab” ...
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    The Unsensored Version (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 133-133 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biosensors: Applications in Medicine, Environmental Protection and Process Control. R.D. Schmid & F. Scheller, eds. ISBN 0-89573-955-0. DM128.00 (VCH Publishers, Heidelberg: 1989). Biosensors. Elizabeth A. H. Hall. ISBN 0-335-15894-3 £50.00 (cased) (Open University Press, Milton Keynes, ...
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    Despite the Best of Intentions (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 132-132 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Any author attempting to chronicle the (lack of) development of drugs to tame the scourge of acquired immunodeficiency syndrome risks falling prey to the sensational. The topic cries out for hyperbole: the federal medical and political bureaucracies' slow response to the spread of the syndrome, big ...
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    Artificial Organs From Culture (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 136-137 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Today it is becoming possible to culture organs outside the body—without ever coming from the body in the first place. Truly artificial organs—including liver, bone marrow, and skin—are being grown in Petri dishes and 3T3 flasks in several laboratories around the country. And a ...
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    Location and Design: Two Sides of a Coin (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 139-141 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Urban growth is a mystery. Vhy does one city sprout ip in one place and not mother? Why does one town grow into a metropolis while another remains Old Dimebox, Texas? Because of economics? history? geography? destiny? A similar mystery is the location of biotechnology facilities. Why do so many ...
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    Chromatography of Complex Carbohydrates (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 149-150 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] In essence, all of the chromatographic methods that have been applied so successfully in the analysis and preparation of polypeptides—gel filtration, ion exchange, HPLC, affinity chromatography, and absorption chromatography—are applicable to the separation of complex oligosaccharides. ...
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    Transferring In Vitro Technology to the Field (1991)
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    Nature biotechnology 9 (1991), S. 143-146 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plant tissue culture products could make significant impacts on agriculture. Tissue culture technologies already are yielding plants with improved, heritable variation1. For these products to be useful to the agricultural sector, however, it is necessary to identify and evaluate them under field ...
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    Metal-Affinity Separations: A New Dimension in Protein Processing (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 151-156 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Rapid growth in the preparative and high-resolution analytical applications of metal-affinity chromatography demonstrate the appeal of metal recognition as a basis for protein separations. Stable, inexpensive chelated metals effectively mimic bio-specific interactions, providing selective ligands ...
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    Biotechnology in the U.S.S.R. (1984)
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    Nature biotechnology 2 (1984), S. 788-788 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Several interesting developments in Soviet biotechnology have been published recently. The All Union Scientific Research Institute of Bioengineering in Moscow has developed an experimental computerized information system called “Ellips-Mikrobiologiiya.” A recent report1 claimed the ...
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    New Products (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 813-819 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ionics, Inc. (Watertown, MA) introduces a recirculating isoelectric focusing system called IsoPrep™. It separates proteins of differing pis on a preparative scale under applied electrical potential. The system's membranes permit convection but let proteins migrate freely until they reach a ...
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    Announcements (1984)
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    Nature biotechnology 2 (1984), S. 823-823 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] OCTOBER MEETINGS Oct. 10–11. Robert S. First Conference: The New Microbiology. Washington, B.C. Info: Robert S. First, 707 Westchester Avenue, White Plains, NY 10604 Oct. 11. Today's Profit Opportunities in Biotechnology. Philadelphia, PA. (Also Nov. 15 in Houston, TX.) Info: Consulting ...
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    Chemical and Bacterial Pretreatment of Lignocellulosic Material to Increase Ruminant Digestibility (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 805-807 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A variety of chemical treatments was examined for the ability to decrease the relative lignin content and increase the in vitro dry matter digestibility of peanut hulls. Of these chemical treatments, nitric acid was the most successful at removing lignin; however, none of the chemical treatments ...
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    Nitrogen Fixation in Context (1984)
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    Nature biotechnology 2 (1984), S. 821-821 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Fundamentals of Nitrogen Fixation. J. R. Postgate. Pp. 252. ISBN 0-521-24169-3. (Cambridge University Press, Cambridge, England: 1982) $37.50. This modestly-sized volume reminds me favorably of Harris' Nucleus and Cytoplasm, a small but influential book from my past. Like its ...
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    Chemicals from Algae and Plant Tissue (1984)
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    Nature biotechnology 2 (1984), S. 665-665 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “Single cell protein J polyhydroxybutyrate not the end of the story.” That forecast was made two years ago by Eric Howells from Id's Corporate Research and Technology Department. The real “end of the story”, he suggested, was the use of stable, safe, versatile microorganisms ...
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    Restriction Endonuclease Map of pTi Bo542, a Potential Ti Plasmid Vector for Genetic Engineering of Plants (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 702-709 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We report here a physical map of pTi Bo542, a wide-host-range tumor-inducing plasmid of Agrobacterium tumefaciens. Forty-two fragments generated by the restriction endonuclease Bam HI were arranged in a circular array using electrophoretic analysis of clones containing overlapping segments of pTi ...
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    Bioregulation of Lipid and Protein Synthesis in Soybean by 2-Diethylaminoethyl-3,4-Dichlorophenylether (1984)
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    Nature biotechnology 2 (1984), S. 712-714 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Application of the bioregulator 2-diethyla-minoethyl-3,4-dichlorophenylether (DCP-TA) causes significant increases in the lipid (triglyceride) and protein content of the soybean. At the same time, soybean yield is enhanced. No negative relationships among the constituents and yield are observed. ...
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    New Products (1984)
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    Nature biotechnology 2 (1984), S. 715-719 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] 1.5 ml micro centrifuge tubes made of high transparency polypropylene and compatible with most centrifuges are available from Tekmar Co. The tubes feature two writing surfaces and are marked at the 1.5, 1.0, 0.5, and 0.1 ml levels. Write in 301 on Reader Service Card. Bio-Rad Laboratories' ...
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    Agricultural Research and Policy (1984)
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    Nature biotechnology 2 (1984), S. 721-721 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Genetic Engineering of Plants. Edited by the Board on Agriculture of the National Research Council. Pp. 96. ISBN 0-309-03434-5. (National Academy Press, Washington, D.C.: 1984) $9.50 In Genetic Engineering of Plants, Leslie Roberts and the staffs of the Council for Research Planning in ...
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    ‘Gene Machines’ and a New Approach (1984)
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    Nature biotechnology 2 (1984), S. 694-695 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Many problems in biotechnology begin with the question “How do we get synthetic DNA in hand?” In the early days of DNA synthesis only a few talented chemists could copy nature in the lab, and no biologist dared request synthetic DNA from these specialists. Nowadays chemical synthesis of ...
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    Use of a specific Monoclonal Antibody for the Preparation of a Highly Active Immobilized Carboxypeptidase A (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 709-712 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A mouse monoclonal antibody (Ab 100) to carboxypeptidase A (CPA) which binds to the enzyme with a high affinity constant (∼109 M−1) without affecting its catalytic activity was prepared, purified and characterized. Covalent binding of the monoclonal antibody to Eupergit C, or noncovalent ...
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    Announcements (1984)
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    Nature biotechnology 2 (1984), S. 720-720 
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    Notes: [Auszug] SEPTEMBER MEETINGS Sept. 5–7. 6th Australian Biotechnology Conference. Brisbane, Australia. Info: H. W. Doelle, Dept. of Microbiology, University of Queensland, St. Lucia, Qld. 4067, Australia Sept. 9–13. Propogation of Higher Plants Through Tissue Culture III. Knoxville, TN. Info: ...
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    DNA Probe Rights: A Tangled Web (1984)
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    Nature biotechnology 2 (1984), S. 589-590 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] NEW YORK NY—At least three major companies in biotechnology are caught up in the web of patents covering DNA probes—and a complex conflict seems inevitable. Enzo Biochem's non-isotopic DNA probe system, which stains infected cells brown, is used here to detect Chlamydia trachomatis, a ...
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    Co-Immobilization Speeds Lactose Breakdown (1984)
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    Nature biotechnology 2 (1984), S. 594-594 
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    Notes: [Auszug] LONDON—Another novel approach to the exploitation of cheap and abundant lactose in whey and other wastes was described at Biotech 84 by W. Hartmeier from the Technische Hochschule Aachen in West Germany. Hartmeier reported that co-immobilization of yeast or bacterial cells with ...
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    Biotech Taking Root in Japanese Agriculture (1984)
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    Nature biotechnology 2 (1984), S. 603-603 
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    Notes: [Auszug] TOKYO—The Japanese Ministry of Agriculture, Forestry and Fisheries' new budget for biotechnology has jumped more than 90 percent, to 1.2 billion yen ($5.2 million). This contrasts with a planned 20 percent increase in overall government spending on biotechnology. The Ministry has ...
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    Formulating a Manufacturing Strategy (1984)
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    Nature biotechnology 2 (1984), S. 616-618 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A number of well financed, well managed biotechnology-oriented companies have survived the initial “shakeout” typical of embryonic high technology industries and are at the stage where they have a product or a group of products that are close to commercialization. In some cases, ...
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    Kidney Plasminogen Activator: A Precursor Form of Human Urokinase With High Fibrin Affinity (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 628-634 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A systematic screen of human kidney tissue samples has resulted in the establishment of a permanent cell line, TCL-598, which produces and secretes into the medium milligrams per liter quantities of a urokinase-like plasminogen activator. Analysis of the properties of this enzyme indicate that it ...
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    Improvement Of Oligonucleotide-Directed Site-Specific Mutagenesis Using Double-Stranded Plasmid DNA (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 636-639 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Conditions which gave a high yield of oligonucleotide-directed site specific mutagenesis were obtained with use of the lpp gene of Escherichia coli cloned in the versatile expression plasmid vector, pIN-II. This plasmid (5.6-kb) was digested by PstI followed by exonuclease (Klenow fragment of DNA ...
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    A Little Secrecy Goes a Long Way (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 494-494 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Extensive research and development in other product areas continues at a highly productive pace. Some of this you have heard about, but much you have not. For business and competitive reasons, we have chosen to delay discussing certain products until they are further along the development ...
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