ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Animals  (7,118)
  • 42.75
  • AERODYNAMICS
  • 2010-2014  (7,167)
  • 1925-1929  (1)
  • 1
    facet.materialart.
    Unknown
    Twee nieuwe tweestaarten in Nederland (Diplura) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.5
    Details
    Publication Date: 2017-03-16
    Description: Tweestaarten Diplura behoren met de springstaarten Collembola en beentasters Protura tot de Entognatha. Dat zijn kleine ongevleugelde bodemdieren met zes poten, die zich onderscheiden van de insecten door hun verzonken monddelen. Tot nu toe waren twee soorten voor Nederland gemeld, maar voor België 13. Tijdens een onderzoek naar in mierennesten levende organismen werden twee soorten gevonden die nog niet uit Nederland bekend waren. Verder onderzoek zal zeker nog meer nieuwe tweestaarten kunnen opleveren.
    Keywords: Diplura ; Nederland ; Campodea lubbocki ; Campodea plusiochaeta ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 2
    facet.materialart.
    Unknown
    De kriebelmuggen van Nederland en Vlaanderen (Diptera: Simuliidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.67
    Details
    Publication Date: 2017-03-16
    Description: Larven van kriebelmuggen komen uitsluitend voor in stromend water, waar ze met hun waaiervormige monddelen deeltjes filteren uit het voorbij stromende water. Het zijn goede indicatoren voor zuurstofrijk water. Tot nu toe was niet duidelijk welke soorten precies voorkomen in Nederland en België en de determinatie van kriebelmuggen wordt vaak als lastig beschouwd. Om dit te verhelpen, presenteren we hier determinatietabellen voor alle in Nederland en België voorkomende soorten, zowel voor larven van het laatste stadium als voor poppen.
    Keywords: Diptera ; Simuliidae ; Nederland ; België ; herkenning ; verspreiding ; ecologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 3
    facet.materialart.
    Unknown
    Recente aanvullingen op de Nederlandse loopkevercatalogus (Coleoptera: Carabidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.17
    Details
    Publication Date: 2017-03-16
    Description: De catalogus van de Nederlandse kevers uit 2010 geeft het meest recente overzicht van de Nederlandse kevers. Er staan 372 soorten loopkevers op deze lijst. Per soort wordt een overzicht gegeven van de provincies waaruit waarnemingen bekend zijn. Voor elk zogenaamd provincierecord is een collectie-exemplaar aangeduid als bewijsexemplaar. Sinds 2010 is er veel nieuwe informatie over loopkevers bekend geworden. In dit artikel worden de wijzigingen in de lijst toegelicht.
    Keywords: Coleoptera ; Carabidae ; Nederland ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 4
    facet.materialart.
    Unknown
    De reuzenertswesp Leucospis dorsigera nieuw voor Nederland (Hymenoptera: Chalcidoidea) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.1
    Details
    Publication Date: 2017-03-16
    Description: Hoe een leek op het gebied van wespen en bijen toch een leuke vondst kan doen. Op zonnige dagen gaat de auteur regelmatig op ‘tuinsafari’. Een tuin waarin rekening wordt gehouden met vogels en insecten, door keuze van beplanting en het ophangen van insectenhotels. De inspanningen leverden op 23 juli 2014 een opvallende wesp op. In een bijna automatische reactie werden snel foto’s gemaakt, in de hoop ze later te kunnen determineren. De wesp vloog daarna weg en werd niet meer gezien. Na determinatie blijkt het reuzenertswesp Leucospis dorsigera te zijn, een nieuwe soort bronswesp voor Nederland.
    Keywords: Hymenoptera ; Chalcidoidea ; Leucospis dorsigera ; Nederland ; herkenning ; biologie ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 5
    facet.materialart.
    Unknown
    Twee nieuwe citroenzweefvliegen voor Nederland: Xanthogramma dives en X. stackelbergi (Diptera: Syrphidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.27
    Details
    Publication Date: 2017-03-16
    Description: De gewone citroenzweefvlieg Xanthogramma pedissequum is een eenvoudig te herkennen zweefvlieg. Tenminste, dat dachten we tot voor kort. Nu blijkt dat de bijna identieke X. dives en X. stackelbergi ook in Nederland rondvliegen. Gelukkig zijn er enkele kenmerken waarmee deze drie soorten citroenzweefvlieg in het veld redelijk herkenbaar blijken. In dit artikel bespreken we deze kenmerken en geven we informatie over verspreiding en vliegtijden van de drie soorten.
    Keywords: Diptera ; Syrphidae ; Xanthogramma dives ; Xanthogramma stackelbergi ; Nederland ; herkenning ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 6
    facet.materialart.
    Unknown
    Blaaskopvliegen van het genus Leopoldius in de Benelux (Diptera: Conopidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.55
    Details
    Publication Date: 2017-03-16
    Description: Wespblaaskoppen Leopoldius worden ondanks hun opvallende uiterlijk maar weinig waargenomen. De soorten zijn lastig van elkaar te onderscheiden en bovendien werden tot voor kort variabele kenmerken gebruikt, wat tot veel verwarring heeft geleid. Nu blijkt dat alleen vrouwtjes met zekerheid te herkennen zijn aan de vorm van het klampje. Dit is een lepelvormig uitsteeksel onder het vijfde achterlijfsegment. Het wordt gebruikt bij het afzetten van eieren op een gastheer. Waarschijnlijk zijn limonadewespen de belangrijkste gastheer van Leopoldius. In dit artikel wordt een nieuwe soort voor België en een nieuwe soort voor Luxemburg gemeld. Daarnaast wordt een overzicht geboden van waarnemingen in Nederland, België en Luxemburg en een sleutel tot de Noordwest-Europese soorten.
    Keywords: Diptera ; Conopidae ; Leopoldius ; Nederland ; België ; Luxemburg ; herkenning ; biologie ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 7
    facet.materialart.
    Unknown
    Eerste larvenvondst van de kokerjuffer Molanna albicans buiten Drenthe (Trichoptera: Molannidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.93
    Details
    Publication Date: 2017-03-16
    Description: Ondanks de fors toegenomen aandacht voor watermacrofauna sinds begin jaren 1980 is de schietmot Molanna albicans maar sporadisch aangetroffen. In dit artikel wordt de eerste larvenvondst van M. albicans buiten Drenthe beschreven. Samen met de vindplaatsen in Drenthe is de soort nu van vijf vennen in Nederland bekend. Aanvullend worden de determinatiekenmerken aan de hand van foto’s geïllustreerd.
    Keywords: Trichoptera ; Molannidae ; Molanna albicans ; Nederland ; verspreiding ; biologie ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 8
    facet.materialart.
    Unknown
    Spatial and temporal distribution of caddisfly larvae in two lowland streams in The Netherlands (Trichoptera) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.81
    Details
    Publication Date: 2017-03-16
    Description: Caddisflies are a species rich insect order. The adults are moth-like, but their wings bear hairs instead of scales. The larvae are aquatic and live in self-constructed cases, made of plant material, sand or debris. The species are used as indicators of water quality, but much is still not known about their biology and ecology. In this paper the preferred substrates and phenology of the larvae of 13 species are described, using the data of a survey of two lowland streams in the east of the Netherlands.
    Keywords: Trichoptera ; ecology ; phenology ; Netherlands ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 9
    facet.materialart.
    Unknown
    Slakkendodende vliegen van het genus Psacadina in Nederland en België (Diptera: Sciomyzidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.37
    Details
    Publication Date: 2017-03-16
    Description: Slakkendodende vliegen danken hun naam aan hun roofzuchtige, parasitaire larven, die het op slakken gemunt hebben. Uit België en Nederland zijn circa 60 soorten uit deze familie bekend, maar er zijn er zeker meer te ontdekken. Dit artikel meldt een nieuwe soort voor de Nederlandse fauna uit het genus Psacadina, dat in beide landen drie soorten telt. De herkenning en het voorkomen van de drie soorten wordt uitgebreid besproken.
    Keywords: Diptera ; Sciomyzidae ; Psacadina ; Nederland ; België ; biologie ; herkenning ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 10
    facet.materialart.
    Unknown
    De zwarte vlieg Bibio venosus nieuw voor de Nederlandse fauna (Diptera: Bibionidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.33
    Details
    Publication Date: 2017-03-16
    Description: Zwarte vliegen behoren tot de muggen, maar door hun korte antennen doen ze oppervlakkig aan vliegen denken. De mannetjes zien er met hun grote kop en grote ogen heel anders uit dan de vrouwtjes, die een kleine kop met kleine ogen hebben. In het voorjaar vormen sommige soorten opvallend grote zwermen op windluwe plekken. Aan de 17 soorten die reeds uit Nederland bekend waren, kan er nu één worden toegevoegd: Bibio venosus.
    Keywords: Diptera ; Bibionidae ; Bibio venosus ; herkenning ; biologie ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 11
    facet.materialart.
    Unknown
    Uitbreiding van de hooiwagen Astrobunus leavipes (Opiliones) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.11
    Details
    Publication Date: 2017-03-16
    Description: Astrobunus laevipes is een hooiwagen die via het Rijnbekken recentelijk ons land is binnengekomen. Er waren al vondsten langs de Waal en Nederrijn in Gelderland en het meest oostelijke puntje van de provincie Utrecht. Door gerichte inventarisaties kunnen wij de hooiwagen nu nieuw voor de provincies Zuid-Holland en Noord-Brabant melden. Daarnaast is er van A. laevipes nu ook een waarneming langs de IJssel en enkele westelijker in de provincie Utrecht. Allerlei rivierbegeleidende biotopen langs (uitlopers van) de Nederrijn en Waal worden al door deze opmerkelijke hooiwagen bevolkt, maar de noordelijke uitbreiding via de IJsselvallei lijkt veel trager te verlopen. De Maas lijkt nog niet bereikt.
    Keywords: Opiliones ; Astrobunus leavipes ; Nederland ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 12
    facet.materialart.
    Unknown
    Sensitivities of marine macrozoobenthos to environmental pressures in the Netherlands (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.79
    Details
    Publication Date: 2015-12-09
    Description: The relative sensitivities of 309 common invertebrate species in Dutch marine waters are presented for environmental and anthropogenic pressures like organic enrichment, sedimentation and fisheries. The species were furthermore appointed to trophic groups like suspension and deposit feeders. The Dutch Ministry of Infrastructure and the Environment uses these data when calculating the Benthic Ecosystem Quality Index 2 and the Infaunal Trophic Index. These metrics aid in the mandatory monitoring of ecological quality for example for the European Water Framework Directive. The common Dutch species were selected based on their abundance according to, 1. the mwtl dataset including results of on-going monitoring programs issued by the Ministry, 2. the monitoring by volunteer scuba-divers for the anemoon Foundation and 3. the monitoring of fouling plates for the project setl.
    Keywords: macrozoobenthos ; marine ; Netherlands ; environment ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 13
    facet.materialart.
    Unknown
    De zeepissebed Uromunna spec, de eerste waarneming van de familie Munnidae in Nederland (Isopoda) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.43
    Details
    Publication Date: 2015-12-09
    Description: Onze fauna verandert en de mariene fauna is daarop geen uitzondering. Zuidelijke soorten koloniseren onze kustwateren en exotische soorten worden door de mens aangevoerd. Voor sommige soorten is niet duidelijk waarom ze hier opduiken. De sterk veranderende kustbiotopen spelen ongetwijfeld eveneens een rol. Een niet-aflatende stroom onverwachte soorten, soms zelfs behorend tot nieuwe genera en zelfs families maken faunistisch onderzoek in de kustwateren verrassend en boeiend. In het kader van een inventarisatie van kreeftachtigen in het Deltagebied werden in de Oosterschelde bij Zierikzee verscheidene kleine monsters genomen van diverse substraten. De monsters van roodwieren bevatten een aantal opmerkelijke soorten. Dit artikel behandelt Uromunna spec., een zeepissebeddensoort van een familie die in ons land nog niet was aangetroffen.
    Keywords: Isopoda ; Munnidae ; Nederland ; Uromunna ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 14
    facet.materialart.
    Unknown
    First record of a settled stomatopod Platysquilla eusebia in the North Sea (Malacostraca: Stomatopoda) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.31
    Details
    Publication Date: 2015-12-09
    Description: This paper describes the discovery of a settled juvenile specimen of the stomatopod Platysquilla eusebia on the Dutch part of the Dogger Bank in the central North Sea. This is the northernmost record in Europe. The species is native to the Mediterranean and to the Atlantic coast from Portugal up to France. Further investigations have to show if the species already forms populations this far north. As the planktonic stages of P. eusebia have already been recorded in prior years, the establishment of the species should not be a problem, providing the circumstances are favourable.
    Keywords: Malacostraca ; Stomatopoda ; Platysquilla eusebia ; distribution ; Netherlands ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 15
    facet.materialart.
    Unknown
    De springstaart Fasciosminthurus quinquefasciatus nieuw voor de Nederlandse fauna (Collembola: Bourletiellidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.1
    Details
    Publication Date: 2015-12-09
    Description: Met enige regelmaat duiken nieuwe springstaartsoorten op in ons land. Het vinden van een nieuwe soort is soms op toeval gebaseerd. Op een foto van een sprinkhaan was naast de linker voorpoot een klein, donker vlekje te zien. Uitvergroot bleek het om een klein springstaartje te gaan. Het zwart-wit gestreepte patroon liet geen ruimte voor twijfel over de determinatie: Fasciosminthurus quinquefasciatus, een nieuwe springstaart voor de Nederlandse fauna. In dit artikel wordt het genus en de soort voorgesteld, beschrijven we de habitat en geven we informatie over de verspreiding in de rest van Europa.
    Keywords: Collembola ; Bourletiellidae ; Fasciosminthurus quinquefasciatus ; Nederland ; verspreiding ; herkenning ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 16
    facet.materialart.
    Unknown
    Duistere heiderouwzwever Exoprosopa cleomene duikt op in Nederlandse wolzwevercollectie (Diptera: Bombyliidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.49
    Details
    Publication Date: 2015-12-09
    Description: De roodbruine heiderouwzwever Exoprosopa capucina is een fraaie en karakteristieke koffiebruine verschijning op de Nederlandse heideterreinen. Zoals veel wolzwevers is deze te herkennen aan de vleugeltekening en de kleur van de lichaamsbeharing. Echter naarmate de dieren ouder worden verliezen ze deze beharing en wordt de determinatie lastiger. Vermoedelijk heeft het verfomfaaide uiterlijk van een vrouwtje Exoprosopa cleomene er voor gezorgd dat deze ruim 50 jaar onopgemerkt tussen de exemplaren van E. capucina heeft gestaan.
    Keywords: Diptera ; Bombyliidae ; Exoprosopa cleomene ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 17
    facet.materialart.
    Unknown
    Sulcacis bidentulus, een nieuwe houtzwamkever voor de Nederlandse fauna (Coleoptera: Ciidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.7
    Details
    Publication Date: 2015-12-09
    Description: In de afgelopen jaren werd op verschillende plekken in Nederland een houtzwamkever gevonden die tot nu toe niet officieel gemeld werd: Sulcacis bidentulus. Deze soort valt binnen de zeer eenvormige familie Ciidae op door de kleur van de dekschilden, die duidelijk iets lichter bruin zijn dan de rest van het lichaam. De soort zou zich ontwikkelen in de bleke borstelkurkzwam, die voornamelijk op populieren groeit. Oudere vondsten ontbreken en de ontdekking van deze soort op meerdere locaties duidt op een recente vestiging in ons land. Dit sluit aan bij de geconstateerde uitbreiding in Midden-Europa.
    Keywords: Coleoptera ; Ciidae ; Sulcacis bidentulus ; Nederland ; verspreiding ; biologie ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 18
    facet.materialart.
    Unknown
    Vierde aanvulling op de naamlijst van Nederlandse sluipvliegen (Diptera: Tachinidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.43
    Details
    Publication Date: 2017-03-16
    Description: De familie der sluipvliegen is één der soortenrijkste vliegenfamilies in ons land. De larven ontwikkelen zich inwendig in ongewervelden, veelal vlinderrupsen. De familie is in ons land relatief goed bestudeerd. In dit artikel wordt wederom een soort voor het eerst uit ons land vermeld. Hiermee komt het totaal aantal soorten dat in Nederland ooit vastgesteld is op 334.
    Keywords: Diptera ; Tachinidae ; Pexopsis aprica ; Nederland ; verspreiding ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 19
    facet.materialart.
    Unknown
    Bamboewormen in Nederland, met Micromaldane ornithochaeta nieuw voor Nederland (Polychaeta: Maldanidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.111
    Details
    Publication Date: 2017-03-16
    Description: Mariene borstelwormen vormen een ecologisch belangrijke, soortenrijke groep. Van diverse families is niet veel bekend over het voorkomen in Nederland en de bamboewormen (familie Maldanidae) behoren tot de slechtst bekende groepen. Bamboewormen danken hun naam aan de lange en aan het uiteinde verdikte segmenten. In dit artikel wordt een nieuwe bamboeworm voor Nederland besproken en een opsomming gegeven van de nu bekende inheemse soorten.
    Keywords: Polychaeta ; Maldanidae ; Micromaldane ornithochaeta ; Nederland ; herkenning ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 20
    facet.materialart.
    Unknown
    Slakkendodende vliegen van het genus Anticheta in Nederland, met twee soorten nieuw voor de fauna (Diptera: Sciomyzidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.47
    Details
    Publication Date: 2017-03-16
    Description: Slakkendodende vliegen zijn nog relatief slecht onderzocht in ons land, zeker de kleine soorten. De vertegenwoordigers van het genus Anticheta zijn kleine vliegjes, waarvan slechts twee soorten uit ons land bekend waren. Uitgebreider onderzoek, zowel in collecties als in het veld, heeft twee nieuwe soorten voor de fauna aan het licht gebracht: Anticheta nigra en A. obliviosa. Van de eerste soort waren wereldwijd slechts acht exemplaren bekend.
    Keywords: Diptera ; Sciomyzidae ; Anticheta ; Nederland ; herkenning ; biologie ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 21
    facet.materialart.
    Unknown
    Het dotterbloemgitje Cheilosia frontalis nieuw voor Nederland (Diptera: Syrphidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.37
    Details
    Publication Date: 2017-03-16
    Description: Zelfs in een goed onderzochte insectengroep als de zweefvliegen zijn nog altijd nieuwe soorten voor de Nederlandse fauna te ontdekken. Ook in 2014 was het weer raak, dit keer in het fraaie natuurgebied rond de Drentsche Aa. Het lijkt niet toevallig dat deze aanvulling op de Nederlandse fauna juist hier werd gevonden. Deze vindplaats vult ecologische informatie uit het buitenland aan, waardoor langzamerhand een beeld begint te ontstaan van de levenswijze van deze zeldzame zweefvlieg, waarover tot voor kort weinig bekend was.
    Keywords: Diptera ; Syrphidae ; Cheilosia frontalis ; Nederland ; herkenning ; biologie ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 22
    facet.materialart.
    Unknown
    Nieuwe vondsten van de doornkaakzandbij Andrena trimmerana in Nederland (Hymenoptera: Apoidea: Andrenidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.75
    Details
    Publication Date: 2017-03-16
    Description: De doornkaakzandbij ziet er in het voorjaar een beetje anders uit dan in de zomer. Daarom worden de voorjaarsdieren door sommigen tot een andere soort beschouwd dan de zomerdieren. Uit Nederland zijn slechts drie exemplaren bekend: twee uit het voorjaar en één uit de zomer. Toevallig komen alle exemplaren uit hetzelfde gebied. Of is dit geen toeval?
    Keywords: Hymenoptera ; Apoidea ; Andrenidae ; Andrena trimmerana ; Nederland ; herkenning ; verspreiding ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 23
    facet.materialart.
    Unknown
    Vestiging van de boomkrekel Oecanthus pellucens in het rivierengebied (Orthoptera) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.35
    Details
    Publication Date: 2015-12-09
    Description: De boomkrekel is een slanke geelbruine krekel, die vooral opvalt door zijn melodieuze zang. Vroeger moest je naar Frankrijk om dit geluid te horen, maar tegenwoordig heerst ook in het rivierengebied bij Nijmegen een mediterrane sfeer. De boomkrekel is in 2004 voor het eerst langs de Waal gevonden en heeft zich daarna uitgebreid. In 2010 en 2011 heeft de Flora- en faunawerkgroep Gelderse Poort met vele vrijwilligers onderzoek gedaan naar de precieze verspreiding. In totaal werd de boomkrekel in 57 kilometerhokken gevonden en de verwachting is dat de soort zich de komende jaren verder zal uitbreiden.
    Keywords: Orthoptera ; Oecanthus pellucens ; Nederland ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 24
    facet.materialart.
    Unknown
    De Nederlandse hongerwespen (Hymenoptera: Evanioidea: Gasteruptiidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.55
    Details
    Publication Date: 2015-12-09
    Description: Hongerwespen behoren tot de grote groep van de sluipwespen. Het zijn slanke wespjes die typisch met hangende pootjes vliegen, waarbij de verbrede achterschenen opvallen. Ze parasiteren bijen en mogelijk ook bepaalde angeldragende wespen en worden daarom vaak bij bijenhotels waargenomen. In het kader van dit artikel zijn de meldingen van Nederlandse hongerwespen kritisch beschouwd. In totaal zijn nu negen soorten uit ons land bekend, waarvan er hier maar liefst zes voor het eerst worden gemeld.
    Keywords: Hymenoptera ; Evanioidea ; Gasteruptiidae ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 25
    facet.materialart.
    Unknown
    Marine fauna of hard substrata of the Cleaver bank and Dogger bank (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.69
    Details
    Publication Date: 2015-12-09
    Description: As most of the sea bottom in the Dutch part of the North Sea consists of sand, marine fauna that live in association with hard substrates are rarely monitored. We report here on the results of a species inventory in June 2011 done by scuba-diving while focusing on a wreck on the Dogger Bank and on rocky bottoms on the Cleaver Bank. This resulted in various new records of species for the Dutch part of the North Sea. This result appeared for a large part linked to the added value of monitoring with scuba-divers. It is therefore concluded that scuba-divers should be used in addition to the more traditional monitoring methods in which dredges and grabs are used, if one aims at getting an accurate view of the biodiversity present in marine regions like the North Sea.
    Keywords: biodiversity ; hard substrata ; Netherlands ; marine ; scuba-diving ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 26
    facet.materialart.
    Unknown
    Benthic communities on hard substrates within the first Dutch offshore wind farm (OWEZ) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.59
    Details
    Publication Date: 2015-12-09
    Description: Five years after the commissioning of the offshore wind farm Egmond aan Zee, the monopiles and the rocks of the scour protection layers were covered by a wide variety of marine organisms. This paper describes the results of qualitative and quantitative assessments carried out in 2008 and 2011. The assessments were based on video footage, pictures and samples collected by divers at three different wind turbines. The ecological relevance of identified taxa is also discussed.
    Keywords: offshore wind farms ; Netherlands ; biodiversity ; benthic zone ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 27
    facet.materialart.
    Unknown
    De gouden kegelbij Coelioxys aurolimbata teruggevonden in het rivierengebied (Hymenoptera: Apoidea: Megachilidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.39
    Details
    Publication Date: 2015-12-09
    Description: De gouden kegelbij Coelioxys aurolimbata is uit ons land recent alleen bekend uit de zuidelijke helft van Limburg. Vóór 1960 kwam deze parasiet van de lathyrusbij Chalicodoma ericetorum ook in het rivierengebied voor. In juli van dit jaar werd de gouden kegelbij gevangen in Duiven. Mogelijk is dit de voorbode van een herovering van het rivierengebied door deze bedreigde soort.
    Keywords: Hymenoptera ; Apoidea ; Megachilidae ; Nederland ; Coelioxys aurolimbata ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 28
    facet.materialart.
    Unknown
    The juwel anemone Corynactis viridis, a new order for the Netherlands (Cnidaria: Corallimorpharia) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.35
    Details
    Publication Date: 2015-12-09
    Description: During an expedition with scuba-divers to the Dutch part of the Brown Ridge in the central North Sea in June 2013, two colonies of the jewel anemone Corynactis viridis were found on the wreck Anna Graebe. With the jewel anemone both a new species and a new animal order, the Corallimorpharia, are added to the autochthonous fauna of the Netherlands. This species typically occurs in the Mediterranean and along the Atlantic coast from Portugal and the west British Isles up to Shetland. As other records of settled colonies of C. viridis in the North Sea were recently reported from Belgian, German and English waters, it is concluded that the jewel anemone, which used to be known as an occasional visitor, should now be considered autochthonous in the North Sea.
    Keywords: Cnidaria ; Corallimorpharia ; Netherlands ; Corynactis viridis ; distribution ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 29
    facet.materialart.
    Unknown
    Het Sachalin-elfje Melangyna pavlovskyi nieuw voor Nederland (Diptera: Syrphidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.29
    Details
    Publication Date: 2017-03-16
    Description: Elfjes behoren tot de vroegste zweefvliegen die in het voorjaar uit de pop kruipen. Rond bloeiende wilgen wemelt het vaak van wilgenelfjes Melangyna lasiophthalma, waardoor het zoeken naar de zeldzamere soorten soms lastig is. Toch zijn de meeste soorten relatief makkelijk van elkaar te onderscheiden. Met de vondst van het Sachalinelfje M. pavlovskyi wordt het echter weer iets lastiger.
    Keywords: Diptera ; Syrphidae ; Melangyna pavlovskyi ; Nederland ; herkenning ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 30
    facet.materialart.
    Unknown
    Drie steltmuggen nieuw voor Nederland (Diptera: Limoniidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.19
    Details
    Publication Date: 2017-03-16
    Description: Steltmuggen lijken op langpootmuggen en zijn daar nauw aan verwant. Veel soorten zijn groot en karakteristiek gekleurd, maar toch zijn ze in Nederland nog weinig bestudeerd. Dit artikel bewijst dat er nog veel te ontdekken valt: in één jaar tijd zijn drie soorten gevonden die nog niet uit ons land bekend waren: Atypophthalmus inustus, Molophilus niger en Arctoconopa melampodia. Hiermee komt het totaal aantal soorten voor Nederland op 149. De nieuwe meldingen sluiten goed aan op het bekende verspreidingsgebied.
    Keywords: Diptera ; Limoniidae ; Nederland ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 31
    facet.materialart.
    Unknown
    De wants Jalla dumosa na 45 jaar weer in Nederland waargenomen (Heteroptera: Pentatomidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.9
    Details
    Publication Date: 2017-03-16
    Description: Jalla dumosa is een in Nederland zeer zeldzame pentatomide, die in 1969 voor het laatst was waargenomen op Terschelling. Na 45 jaren zonder waarnemingen werd ze in 2014 weer in klein aantal waargenomen in de Kooiduinen op Ameland. Rupsen van onder andere de duinparelmoervlinder en de sint-jansvlinder stonden daar op het menu. In deze bijdrage wordt informatie samengevat over de vondsten in Nederland, de biologie en de verspreiding van de soort.
    Keywords: Heteroptera ; Pentatomidae ; Jalla dumosa ; Nederland ; verspreiding ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 32
    facet.materialart.
    Unknown
    The exotic jellyfish Blackfordia virginica introduced into the Netherlands (Cnidaria: Hydrozoa) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.103
    Details
    Publication Date: 2017-03-16
    Description: In August 2014 the exotic jellyfish Blackfordia virginica was captured in the harbour of Amsterdam. This is the first confirmed record of this species in the Netherlands, although in October 2013 a possible specimen was filmed and released. This indicates that the species might be established in the Amsterdam area, although repeated introduction with ballast water cannot be ruled out. In September 2014 hydrozoan polyp colonies closely resembling those of B. virginica were collected near IJmuiden in the Noordzeekanaal, a canal connecting Amsterdam with the North Sea at IJmuiden.
    Keywords: Cnidaria ; Hydrozoa ; Blackfordia virginica ; Netherlands ; exotic species ; distribution ; identification ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 33
    facet.materialart.
    Unknown
    Het hooiwagengenus Trogulus in Nederland (Opiliones: Trogulidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.1
    Details
    Publication Date: 2017-03-16
    Description: Wie een steen of boomstronk omkeert en voor het eerst een Trogulus opmerkt, zal dit bizarre beest niet direct associëren met een hooiwagen. Met de korte, stevige poten, het afgeplatte achterlijf dat overdekt is met strooisel en zand, en een trage manier van voortbewegen is het een ongewone verschijning. De soorten van dit geslacht zijn bodembewoners die zich voornamelijk voeden met kleine huisjesslakken. Uit ons land waren tot nu toe twee soorten bekend. De identiteit van een van die twee was lang onzeker, maar door nieuwe inzichten is nu duidelijk om welke soort het werkelijk gaat. In Nederland blijkt bovendien nog een derde soort voor te komen, die hier voor het eerst gemeld wordt.
    Keywords: Opiliones ; Trogulidae ; Trogulus ; Nederland ; herkenning ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 34
    facet.materialart.
    Unknown
    De molkreeften Upogebia deltaura en U. stellata en geassocieerde soorten in de Noordzee (Decapoda: Upogebiidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.15
    Details
    Publication Date: 2015-12-09
    Description: In de bodem van de Noordzee leeft een bijzondere groep van kreeften. Zij brengen hun leven door in een ondergronds gangenstelsel: de molkreeften. Het zijn algemene bewoners van het Friese Front, de Oestergronden en de Klaverbank. In, op en bij deze kreeften leven verschillende andere diersoorten: parasitaire pissebedden, een mosdiertje en twee soorten tweekleppigen. Deze bijdrage gaat in op de ecologie van de molkreeften en hun symbionten.
    Keywords: Decapoda ; Upogebiidae ; Upogebia ; Nederland ; biology ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 35
    facet.materialart.
    Unknown
    Moss animals of the Dutch part of the North Sea and coastal waters of the Netherlands (Bryozoa) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.1
    Details
    Publication Date: 2015-12-09
    Description: Bryozoa or moss animals constitute a conspicuous and species-rich component of hardsubstrate benthic communities in marine and estuarine habitats. To gain insight into the biodiversity of these habitats, knowledge of bryozoan species is indispensable. Since the last comprehensive publication on Dutch species in 2004 much new information has become available. Particularly from the Dutch part of the Continental Flat of the North Sea, the largest natural area of the Netherlands, many new records have been collected. Other reasons to present an updated review are changes in nomenclature, the arrival of some exotic species and identification issues.
    Keywords: Bryozoa ; Netherlands ; checklist ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 36
    facet.materialart.
    Unknown
    Tephrochlaena oraria, een nieuwe afvalvlieg voor de Nederlandse fauna (Diptera: Heleomyzidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.35
    Details
    Publication Date: 2015-12-09
    Description: Heleomyzidae zijn kleine tot middelgrote vliegen. Ze krijgen niet veel aandacht, omdat de meeste soorten een nogal verborgen leven leiden en bovendien niet opvallend gekleurd of getekend zijn. De Nederlandse familienaam, afvalvliegen, is voor de meeste soorten niet echt passend, maar veel soorten van de subfamilie Heteromyzinae, waartoe Tephrochlaena oraria behoort, worden dan wel weer vaker rond afval aangetroffen. Tephrochlaena oraria is echter in meerdere opzichten een buitenbeentje. Met deze soort komt de lijst van Nederlandse Heleomyzidae op 49.
    Keywords: Diptera ; Heleomyzidae ; Tephrochlaena oraria ; Nederland ; verspreiding ; herkenning ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 37
    facet.materialart.
    Unknown
    Komt de vermiljoenkever Cucujus cinnaberinus in azijnzuurvallen (Coleoptera: Cucujidae)? (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.9
    Details
    Publication Date: 2015-12-09
    Description: Cucujus cinnaberinus is een recent voor Nederland ontdekte soort. De kever staat op de Habitatrichtlijn, wat onder meer betekent dat hij beschermd is en dat de populatie gemonitord dient te worden. Inventarisatie en monitoring gebeurt in het algemeen door het weghalen van schors van recent gestorven bomen. Hierdoor wordt het leefgebied van de kever echter flink aangetast. Wij voerden een klein onderzoek uit naar de mogelijkheden om C. cinnaberinus te vangen in azijnzuurvallen, zodat de habitat intact gelaten kan worden en de soort toch geïnventariseerd kan worden. Tijdens het voorjaar van 2013 werden vier vallen opgehangen op een locatie waar zich een populatie van deze soort bevindt. Er werden slechts twee individuen verzameld; de vangmethode lijkt dus niet bijzonder geschikt.
    Keywords: Coleoptera ; Cucujidae ; Cucujus cinnaberinus ; methode ; inventarisatie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 38
    facet.materialart.
    Unknown
    Northward dispersal of the tanaid Zeuxo holdichi to the Netherlands (Crustacea: Tanaidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.95
    Details
    Publication Date: 2015-12-09
    Description: The tanaid Zeuxo holdichi, described in 1990 from Arcachon Bay in southwest France, has since then been recorded from west Portugal to northern Brittany and southwest England. The species is recorded here from the Netherlands, a further northward expansion of the range. It is hypothesised that Z. holdichi may be non-native to Europe.
    Keywords: Crustacea ; Tanaidae ; Zeuxo holdichi ; Netherlands ; distribution ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 39
    facet.materialart.
    Unknown
    Ecological relevance of shipwrecks in the North Sea (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.49
    Details
    Publication Date: 2015-12-09
    Description: This paper reports on observations made during wreck dive expeditions in 2010-2012, in order to investigate the ecological relevance of shipwrecks on the Dutch Continental Shelf (dcs). Shipwrecks are biodiversity hotspots. The number of species recorded on shipwrecks is similar to the number of species found in soft bottoms of the entire dcs. The soft substrates, however, represent a vastly larger habitat on the dcs than the shipwrecks. Amongst many other taxa, juvenile and large Atlantic cod, linear skeleton shrimp, goldsinny wrasses and leopard spotted gobies were found in the shipwreck habitats. The presence of these important species and their absence from many other habitats, illustrate that shipwrecks function as key habitats, nurseries, and refugia that are rare or absent anywhere else in the Netherlands.
    Keywords: shipwrecks ; Netherlands ; biodiversity ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 40
    facet.materialart.
    Unknown
    De hottentottenvilla Villa hottentotta toch op de Nederlandse lijst (Diptera: Bombyliidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.23
    Details
    Publication Date: 2015-12-09
    Description: Wolzwevers zijn vliegen waarvan de larven parasitair leven bij andere insecten. Wolzwevers van het genus Villa veroorzaken vaak determinatieproblemen. Deze problemen lijken verleden tijd met recent gepubliceerde taxonomische inzichten. Eindelijk konden nu ook de Nederlandse exemplaren van dit genus op naam gebracht worden. Deze bleken te behoren tot vier soorten, waarvan er twee vermoedelijk reeds zijn verdwenen.
    Keywords: Diptera ; Bombyliidae ; Villa hottentotta ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 41
    facet.materialart.
    Unknown
    De bijzondere levensloop van de sluipwesp Acrodactyla quadrisculpta op de schaduwstrekspin Tetragnatha montana (Hymenoptera: Ichneumonidae, Araneae: Tetragnathidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.1
    Details
    Publication Date: 2015-12-09
    Description: Sluipwespen van de groep van de Polysphinctini hebben een bijzondere levenswijze. Het vrouwtje van wesp legt een eitje op het achterlijf van een spin. Wanneer het eitje is uitgekomen brengt de larve haar hele leven op het achterlijf van de spin door. Ze maakt kleine wondjes in de huid en voedt zich met lichaamsvloeistof van de spin. Na verloop van tijd ontwikkelt de larve bulten op de rug, een teken dat ze bijna volgroeid is. Ze zuigt dan de spin leeg, de ‘grote slurp’ genaamd, en verpopt zich in het web. In dit artikel wordt de levenswijze van één van deze soorten, Acrodactyla quadrisculpta, voor het eerst beschreven en geïllustreerd.
    Keywords: Hymenoptera ; Ichneumonidae ; Araneae ; Tetragnathidae ; biologie ; Nederland ; Acrodactyla quadrisculpta ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 42
    facet.materialart.
    Unknown
    Galvormende bladwespen op wilg in Nederland (Hymenoptera: Tenthredinidae: Nematinae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.15
    Details
    Publication Date: 2015-12-09
    Description: De bladwespgenera Phyllocolpa, Tubpontania, Pontania en Euura hebben gemeenschappelijk dat ze gallen vormen op wilg. Recentelijk is er veel vernieuwend taxonomisch werk verricht aan deze groepen. In dit artikel wordt de Nederlandse situatie samengevat. Uit oudere literatuur waren 18 soorten bekend en in het recent gepubliceerde gallenboek worden nog eens 11 soorten voor het eerst voor ons land vermeld. In dit artikel worden nog acht soorten aan de lijst toegevoegd en twee soorten worden van de lijst afgevoerd. In totaal zijn nu 35 soorten galvormende bladwespen van wilg uit Nederland bekend.
    Keywords: Hymenoptera ; Tenthredinidae ; Nematinae ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 43
    facet.materialart.
    Unknown
    De gouden stamjager Choerades igneus nieuw voor Nederland (Diptera: Asilidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.47
    Details
    Publication Date: 2017-03-16
    Description: Roofvliegen zijn met 40 Nederlandse soorten een vrij kleine groep, die behoorlijk goed is onderzocht. Het gebeurt dan ook niet vaak dat er een nieuwe soort voor de Nederlandse fauna kan worden opgetekend. De meeste roofvliegen zijn grijze vliegen, zo niet de stamjagers van het genus Choerades. Dit zijn juist vrij opvallend gekleurde vliegen. Zo heeft de rode dennenstamjager Choerades gilvus een rood gekleurd achterlijf. Opmerkelijk genoeg blijkt dat in Nederland juist onder deze opvallende verschijning twee soorten schuilgaan.
    Keywords: Diptera ; Asilidae ; Choerades igneus ; Nederland ; verspreiding ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 44
    facet.materialart.
    Unknown
    Bruchus brachialis, een zaadkever nieuw voor de Nederlandse fauna (Coleoptera: Chrysomelidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.43 (2014) p.23
    Details
    Publication Date: 2017-03-16
    Description: Onlangs werd op een braakliggend terrein in Roermond de zaadkever Bruchus brachialis verzameld. Dit is de eerste Nederlandse vondst van deze zuidelijke soort. Een reeks recente waarnemingen uit de ons omringende landen laat zien dat deze soort al enige jaren in een noordwaartse areaaluitbreiding verwikkeld is. Met deze ontdekking komt het aantal Nederlandse Bruchus-soorten op zeven.
    Keywords: Coleoptera ; Chrysomelidae ; Nederland ; herkenning ; biologie ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 45
    facet.materialart.
    Unknown
    De springstaart Entomobrya unostrigata nieuw voor noordwest Europa (Hexapoda: Collembola: Entomobryidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.63
    Details
    Publication Date: 2017-03-16
    Description: Nieuw gevormd landschap, zoals jonge duinvalleien, opgespoten polders en bedrijventerreinen in ontwikkeling vormen de habitat van gespecialiseerde soorten. Je moet tegen een stootje kunnen om in een dergelijke zandige, schaars begroeide omgeving te overleven. Vooral langdurig warme, droge perioden vormen een probleem voor vochtminnende bodemdieren. De springstaartsoorten die hier overleven zijn warmteminnend en droogteresistent, een bijzondere combinatie voor bodemdieren. Dit geldt ook voor Entomobrya unostrigata, een nieuwe aanwinst voor de fauna van Noordwest-Europa. Er is een aantal populaties van deze soort op de Tweede Maasvlakte gevonden. De dieren zaten hier onder stenen en hout op opgespoten zand.
    Keywords: Collembola ; Entomobryidae ; Entomobrya unostrigata ; Nederland ; herkenning ; verspreiding ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 46
    facet.materialart.
    Unknown
    Sigalionide zeerupsen in Nederland, met Fimbriosthenelais minor nieuw voor Nederland (Polychaeta: Sigalionidae) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.71
    Details
    Publication Date: 2017-03-16
    Description: De Polychaeta vormen een groep van vrijwel uitsluitend mariene wormen, gekenmerkt door een geleed lichaam met aan de meeste leden een tamelijk groot aantal borstels. Het is een soortenrijke groep; ze spelen een belangrijke rol in de ecologie en diversiteit van vooral zachte, maar ook harde zeebodems. In vergelijking met de kreeftachtigen en weekdieren, eveneens soortenrijke groepen in dezelfde biotoop, zijn borstelwormen minder goed onderzocht. In dit artikel wordt de zeerups Fimbriosthenelais minor nieuw voor ons land gemeld. Met name op stenige en schelprijke bodems zijn nog meer nieuwe borstelwormen voor ons land te verwachten.
    Keywords: Polychaeta ; Sigalionidae ; Fimbriosthenelais minor ; Nederland ; herkenning ; verspreiding ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 47
    facet.materialart.
    Unknown
    Verspreiding en biotoop van het kalkdoorntje Tetrix tenuicornis in de Gelderse Poort (Orthoptera) (2014)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.42 (2014) p.55
    Details
    Publication Date: 2017-03-16
    Description: Het kalkdoorntje is een zeldzame sprinkhanensoort, die vooral bekend is uit Zuid-Limburg en van enkele locaties in het rivierengebied. Over het voorkomen van dit kleine sprinkhaantje binnen de Gelderse Poort was lange tijd weinig bekend. Pas vanaf 2007 worden regelmatig waarnemingen gedaan. Toevallige waarnemingen op, voor de auteur, onverwachte locaties vormden de aanleiding voor een grondige inventarisatie in de jaren 2011-2013. Hieruit komt naar voren dat het kalkdoorntje een ruime verspreiding heeft binnen de Gelderse Poort en een meer diverse biotoopkeuze heeft dan voorheen bekend was.
    Keywords: Orthoptera ; Tetrigidae ; Tetrix tenuicornis ; verspreiding ; biologie ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 48
    facet.materialart.
    Unknown
    De rode snuitvlieg Rhingia rostrata terug in Nederland (Diptera: Syrphidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.15
    Details
    Publication Date: 2015-12-09
    Description: Snuitvliegen zijn rare snuiters onder de zweefvliegen. Ze hebben een verlengd gezicht en een lange tong. Hiermee kunnen ze foerageren op bloemen met diepliggende nectar, in tegenstelling tot de meeste andere zweefvliegen. Als genus zijn de vliegen makkelijk herkenbaar, maar de zeer zeldzame soorten tussen de zeer algemene gewone snuitvlieg uithalen was niet altijd even makkelijk. In dit artikel wordt de herontdekking van de rode snuitvlieg beschreven en een tabel gegeven voor de drie Noordwest-Europese soorten.
    Keywords: Diptera ; Syrphidae ; Rhingia rostrata ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 49
    facet.materialart.
    Unknown
    Eerste waarneming van de schietmot Ecclisopteryx dalecarlica in Nederland en nieuwe vondsten in België (Trichoptera: Limnephilidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.89
    Details
    Publication Date: 2015-12-09
    Description: De larven van Trichoptera heten kokerjuffers en leven in het water. Veel soorten bouwen een kokertje van zand, takjes of ander materiaal, vandaar de Nederlandse naam. De volwassen dieren lijken wel wat op nachtvlinders en worden schietmotten genoemd. De laatste jaren heeft het onderzoek naar deze dieren een grote vlucht genomen. Enerzijds spelen ze een rol als indicator voor de waterkwaliteit. De larven worden dan ook veel verzameld tijdens macrofaunabemonsteringen door waterschappen. Anderzijds is er een groeiende groep entomologen die schietmotten bestudeert. In dit artikel wordt Ecclisopteryx dalecarlica voorgesteld, een nieuwe soort voor Nederland.
    Keywords: Trichoptera ; Limnephilidae ; Ecclisopteryx dalecarlica ; Nederland ; Belgie ; verspreiding ; herkenning ; 42.75
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 50
    facet.materialart.
    Unknown
    Sex bias blights drug studies (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2010 Mar 18;464(7287):332-3. doi: 10.1038/464332b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20237530" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bias (Epidemiology) ; Biomedical Research/*methods ; Clinical Trials as Topic/methods ; Drug Evaluation/*methods ; Female ; Humans ; Male ; Patient Selection ; Prejudice ; *Sex Characteristics ; Sex Distribution
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 51
    facet.materialart.
    Unknown
    Human genome at ten: Life is complicated (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2010 Apr 1;464(7289):664-7. doi: 10.1038/464664a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Data Mining ; Gene Expression Regulation ; Genes/genetics ; Genome, Human/*genetics ; Genomics/history/trends ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Humans ; *Models, Biological ; Molecular Biology/*history ; Neoplasms/genetics/therapy ; RNA, Untranslated/genetics/metabolism ; Sea Urchins/embryology/genetics ; Systems Biology/*trends ; Tumor Suppressor Protein p53/chemistry/genetics/metabolism ; *Uncertainty
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 52
    facet.materialart.
    Unknown
    Can conservation cut poverty? (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, Natasha -- England -- Nature. 2010 Sep 16;467(7313):264-5. doi: 10.1038/467264a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844511" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Child ; Conservation of Natural Resources/*statistics & numerical data/trends ; Hominidae ; Humans ; Malnutrition/epidemiology ; Poverty/prevention & control/*statistics & numerical data/trends ; Rivers/chemistry ; United Nations ; Water Supply/statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 53
    facet.materialart.
    Unknown
    A full accounting (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Jun 24;465(7301):985-6. doi: 10.1038/465985b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20577163" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disasters/*economics ; *Ecosystem ; Federal Government ; Industry/*economics ; Insurance/economics/*trends/utilization ; Petroleum/*adverse effects ; Risk ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 54
    facet.materialart.
    Unknown
    River chief resigns (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pincock, Stephen -- England -- Nature. 2010 Dec 9;468(7325):744. doi: 10.1038/468744a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21150966" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/methods ; Animals ; Australia ; *Conservation of Natural Resources/economics ; *Ecosystem ; Endangered Species ; Environmental Policy ; *Leadership ; *Rivers/chemistry ; *Water Supply/analysis/economics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 55
    facet.materialart.
    Unknown
    Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-07-27
    Description: Electrical gradients are critical for many biological processes, including the normal function of excitable tissues, left-right patterning, organogenesis and wound healing. The fundamental mechanisms that regulate the establishment and maintenance of such electrical polarities are poorly understood. Here we identify a gradient of electrical coupling across the developing ventricular myocardium using high-speed optical mapping of transmembrane potentials and calcium concentrations in the zebrafish heart. We excluded a role for differences in cellular excitability, connexin localization, tissue geometry and mechanical inputs, but in contrast we were able to demonstrate that non-canonical Wnt11 signals are required for the genesis of this myocardial electrical gradient. Although the traditional planar cell polarity pathway is not involved, we obtained evidence that Wnt11 acts to set up this gradient of electrical coupling through effects on transmembrane Ca(2+) conductance mediated by the L-type calcium channel. These data reveal a previously unrecognized role for Wnt/Ca(2+) signalling in establishing an electrical gradient in the plane of the developing cardiac epithelium through modulation of ion-channel function. The regulation of cellular coupling through such mechanisms may be a general property of non-canonical Wnt signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921013/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921013/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Panakova, Daniela -- Werdich, Andreas A -- Macrae, Calum A -- K08 HL068711/HL/NHLBI NIH HHS/ -- R21 GM075946/GM/NIGMS NIH HHS/ -- R21 GM075946-01/GM/NIGMS NIH HHS/ -- R21 GM075946-02/GM/NIGMS NIH HHS/ -- R21 GM075946-03/GM/NIGMS NIH HHS/ -- R21 GM075946-04/GM/NIGMS NIH HHS/ -- R21 HL098938/HL/NHLBI NIH HHS/ -- R21 HL098938-01/HL/NHLBI NIH HHS/ -- England -- Nature. 2010 Aug 12;466(7308):874-8. doi: 10.1038/nature09249. Epub 2010 Jul 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brigham and Women's Hospital/Harvard Medical School, Cardiovascular Division, 75 Francis Street, Thorn 11, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20657579" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels, L-Type/*metabolism ; Calcium Signaling ; *Electric Conductivity ; Heart/embryology ; Ion Channel Gating/*physiology ; Myocardium/cytology/*metabolism ; Myocytes, Cardiac/metabolism ; *Signal Transduction ; Wnt Proteins/deficiency/genetics/*metabolism ; Zebrafish/*embryology/metabolism ; Zebrafish Proteins/deficiency/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 56
    facet.materialart.
    Unknown
    Palaeontology: Muddy tetrapod origins (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janvier, Philippe -- Clement, Gael -- England -- Nature. 2010 Jan 7;463(7277):40-1. doi: 10.1038/463040a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20054387" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chordata/anatomy & histology/classification/*physiology ; Extremities/anatomy & histology/physiology ; Fishes/anatomy & histology/physiology ; *Fossils ; Gait/physiology ; History, Ancient ; Models, Biological ; Phylogeny ; Poland
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 57
    facet.materialart.
    Unknown
    The real holes in climate science (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiermeier, Quirin -- England -- Nature. 2010 Jan 21;463(7279):284-7. doi: 10.1038/463284a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090725" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols/analysis ; Animals ; Atmosphere/chemistry ; *Ecology/methods/standards ; Electronic Mail ; Geography ; *Global Warming ; Great Britain ; Human Activities ; Models, Theoretical ; Rain ; Snow ; Trees/anatomy & histology/growth & development ; *Uncertainty
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 58
    facet.materialart.
    Unknown
    The primate connection (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trivedi, Bijal -- England -- Nature. 2010 Jul 15;466(7304):S5. doi: 10.1038/nature09236.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20631704" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/immunology ; Animals ; Chronic Disease ; Disease Models, Animal ; Disease Progression ; Female ; Genome, Viral/genetics ; HIV Infections/*immunology/physiopathology/virology ; HIV-1/genetics/growth & development/immunology ; Host-Pathogen Interactions/immunology ; Immunity, Innate/immunology ; Inflammation/immunology/pathology ; Interleukin-17/immunology ; Macaca/immunology/virology ; Male ; Physiology, Comparative/methods ; Primates/*immunology/metabolism/*virology ; Receptors, HIV/metabolism ; Simian Acquired Immunodeficiency Syndrome/*immunology/metabolism/virology ; Simian Immunodeficiency Virus/classification/genetics/pathogenicity/*physiology ; T-Lymphocytes, Helper-Inducer/immunology/pathology ; Viral Load
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 59
    facet.materialart.
    Unknown
    Males still dominate animal studies (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zucker, Irving -- Beery, Annaliese K -- England -- Nature. 2010 Jun 10;465(7299):690. doi: 10.1038/465690a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departmentsof Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA. irvzuck@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bias (Epidemiology) ; Biomedical Research/ethics/*methods/trends ; *Disease Models, Animal ; Female ; Humans ; Male ; Prevalence ; *Sex Characteristics ; Sex Distribution ; Sex Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 60
    facet.materialart.
    Unknown
    IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-13
    Description: Interleukin (IL)-17-producing helper T (T(H)17) cells are a distinct T-cell subset characterized by its pathological role in autoimmune diseases. IL-6 and transforming growth factor-beta (TGF-beta) induce T(H)17 development, in which the orphan nuclear receptors, RORgammat and RORalpha, have an indispensable role. However, in the absence of IL-6 and TGF-beta, the ectopic expression of RORgammat or RORalpha leads to only a modest IL-17 production. Here we identify a nuclear IkappaB family member, IkappaBzeta (encoded by the Nfkbiz gene), as a transcription factor required for T(H)17 development in mice. The ectopic expression of IkappaBzeta in naive CD4(+) T cells together with RORgammat or RORalpha potently induces T(H)17 development, even in the absence of IL-6 and TGF-beta. Notably, Nfkbiz(-/-) mice have a defect in T(H)17 development and a resistance to experimental autoimmune encephalomyelitis (EAE). The T-cell-intrinsic function of IkappaBzeta was clearly demonstrated by the resistance to EAE of the Rag2(-/-) mice into which Nfkbiz(-/-) CD4(+) T cells were transferred. In cooperation with RORgammat and RORalpha, IkappaBzeta enhances Il17a expression by binding directly to the regulatory region of the Il17a gene. This study provides evidence for the transcriptional mechanisms underlying T(H)17 development and points to a molecular basis for a novel therapeutic strategy against autoimmune disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okamoto, Kazuo -- Iwai, Yoshiko -- Oh-Hora, Masatsugu -- Yamamoto, Masahiro -- Morio, Tomohiro -- Aoki, Kazuhiro -- Ohya, Keiichi -- Jetten, Anton M -- Akira, Shizuo -- Muta, Tatsushi -- Takayanagi, Hiroshi -- Z01-ES-101586/ES/NIEHS NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2010 Apr 29;464(7293):1381-5. doi: 10.1038/nature08922. Epub 2010 Apr 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20383124" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Animals ; Coculture Techniques ; Dendritic Cells/cytology/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; *Gene Expression Regulation ; Interleukin-17/biosynthesis/genetics/*metabolism ; Mice ; NF-kappa B p50 Subunit/metabolism ; Nuclear Proteins/deficiency/genetics/*metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics/*metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics/*metabolism ; Promoter Regions, Genetic/genetics ; T-Lymphocytes, Helper-Inducer/*cytology/*metabolism ; Transcription, Genetic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 61
    facet.materialart.
    Unknown
    Stem cells: Troublesome memories (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zwaka, Thomas P -- England -- Nature. 2010 Sep 16;467(7313):280-1. doi: 10.1038/467280a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844526" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/*genetics ; Cell Lineage/*genetics ; Cellular Reprogramming/genetics ; *DNA Methylation/genetics ; Embryonic Stem Cells/cytology/metabolism ; *Epigenesis, Genetic ; Humans ; Induced Pluripotent Stem Cells/*cytology/*metabolism ; Nuclear Transfer Techniques ; Organ Specificity/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 62
    facet.materialart.
    Unknown
    Amygdalar and hippocampal substrates of anxious temperament differ in their heritability (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-08-13
    Description: Anxious temperament (AT) in human and non-human primates is a trait-like phenotype evident early in life that is characterized by increased behavioural and physiological reactivity to mildly threatening stimuli. Studies in children demonstrate that AT is an important risk factor for the later development of anxiety disorders, depression and comorbid substance abuse. Despite its importance as an early predictor of psychopathology, little is known about the factors that predispose vulnerable children to develop AT and the brain systems that underlie its expression. To characterize the neural circuitry associated with AT and the extent to which the function of this circuit is heritable, we studied a large sample of rhesus monkeys phenotyped for AT. Using 238 young monkeys from a multigenerational single-family pedigree, we simultaneously assessed brain metabolic activity and AT while monkeys were exposed to the relevant ethological condition that elicits the phenotype. High-resolution (18)F-labelled deoxyglucose positron-emission tomography (FDG-PET) was selected as the imaging modality because it provides semi-quantitative indices of absolute glucose metabolic rate, allows for simultaneous measurement of behaviour and brain activity, and has a time course suited for assessing temperament-associated sustained brain responses. Here we demonstrate that the central nucleus region of the amygdala and the anterior hippocampus are key components of the neural circuit predictive of AT. We also show significant heritability of the AT phenotype by using quantitative genetic analysis. Additionally, using voxelwise analyses, we reveal significant heritability of metabolic activity in AT-associated hippocampal regions. However, activity in the amygdala region predictive of AT is not significantly heritable. Furthermore, the heritabilities of the hippocampal and amygdala regions significantly differ from each other. Even though these structures are closely linked, the results suggest differential influences of genes and environment on how these brain regions mediate AT and the ongoing risk of developing anxiety and depression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998538/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998538/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oler, Jonathan A -- Fox, Andrew S -- Shelton, Steven E -- Rogers, Jeffrey -- Dyer, Thomas D -- Davidson, Richard J -- Shelledy, Wendy -- Oakes, Terrence R -- Blangero, John -- Kalin, Ned H -- MH018931/MH/NIMH NIH HHS/ -- MH046729/MH/NIMH NIH HHS/ -- MH059490/MH/NIMH NIH HHS/ -- MH081884/MH/NIMH NIH HHS/ -- MH084051/MH/NIMH NIH HHS/ -- P50 MH084051/MH/NIMH NIH HHS/ -- P50 MH084051-030001/MH/NIMH NIH HHS/ -- R01 MH046729/MH/NIMH NIH HHS/ -- R01 MH046729-17/MH/NIMH NIH HHS/ -- R01 MH081884/MH/NIMH NIH HHS/ -- R01 MH081884-04/MH/NIMH NIH HHS/ -- R37 MH059490/MH/NIMH NIH HHS/ -- R37 MH059490-13/MH/NIMH NIH HHS/ -- England -- Nature. 2010 Aug 12;466(7308):864-8. doi: 10.1038/nature09282.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20703306" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*metabolism ; Animals ; Anxiety/*genetics/*physiopathology ; Depression/genetics ; Female ; Freezing Reaction, Cataleptic ; Genetic Predisposition to Disease/*genetics ; Glucose/metabolism ; *Heredity ; Hippocampus/*metabolism ; Macaca mulatta/genetics/physiology ; Male ; Models, Animal ; Neural Pathways/physiology ; Pedigree ; Phenotype ; Positron-Emission Tomography ; Stress, Psychological ; Temperament/*physiology ; Temporal Lobe/metabolism ; Vocalization, Animal
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 63
    facet.materialart.
    Unknown
    Scientists wanted (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Nov 18;468(7322):346. doi: 10.1038/468346a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Emigration and Immigration/*legislation & jurisprudence/*statistics & numerical ; data ; Employment/statistics & numerical data ; Great Britain ; Internationality ; Research Personnel/*legislation & jurisprudence/standards/*statistics & numerical ; data ; Science/*manpower/standards
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 64
    facet.materialart.
    Unknown
    Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-04
    Description: Polycomb group (PcG) proteins are transcriptional repressors that control processes ranging from the maintenance of cell fate decisions and stem cell pluripotency in animals to the control of flowering time in plants. In Drosophila, genetic studies identified more than 15 different PcG proteins that are required to repress homeotic (HOX) and other developmental regulator genes in cells where they must stay inactive. Biochemical analyses established that these PcG proteins exist in distinct multiprotein complexes that bind to and modify chromatin of target genes. Among those, Polycomb repressive complex 1 (PRC1) and the related dRing-associated factors (dRAF) complex contain an E3 ligase activity for monoubiquitination of histone H2A (refs 1-4). Here we show that the uncharacterized Drosophila PcG gene calypso encodes the ubiquitin carboxy-terminal hydrolase BAP1. Biochemically purified Calypso exists in a complex with the PcG protein ASX, and this complex, named Polycomb repressive deubiquitinase (PR-DUB), is bound at PcG target genes in Drosophila. Reconstituted recombinant Drosophila and human PR-DUB complexes remove monoubiquitin from H2A but not from H2B in nucleosomes. Drosophila mutants lacking PR-DUB show a strong increase in the levels of monoubiquitinated H2A. A mutation that disrupts the catalytic activity of Calypso, or absence of the ASX subunit abolishes H2A deubiquitination in vitro and HOX gene repression in vivo. Polycomb gene silencing may thus entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H2A deubiquitination by PR-DUB.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182123/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182123/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheuermann, Johanna C -- de Ayala Alonso, Andres Gaytan -- Oktaba, Katarzyna -- Ly-Hartig, Nga -- McGinty, Robert K -- Fraterman, Sven -- Wilm, Matthias -- Muir, Tom W -- Muller, Jurg -- R01 GM086868/GM/NIGMS NIH HHS/ -- R01 GM086868-13/GM/NIGMS NIH HHS/ -- RC2 CA148354/CA/NCI NIH HHS/ -- RC2 CA148354-02/CA/NCI NIH HHS/ -- RC2CA148354/CA/NCI NIH HHS/ -- England -- Nature. 2010 May 13;465(7295):243-7. doi: 10.1038/nature08966. Epub 2010 May 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20436459" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Biocatalysis ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/embryology/*enzymology/genetics/metabolism ; Gene Silencing ; Genes, Homeobox/genetics ; Genes, Insect/genetics ; Genetic Complementation Test ; Histones/*metabolism ; Humans ; Multiprotein Complexes/chemistry/isolation & purification/*metabolism ; Nucleosomes/chemistry/metabolism ; Polycomb Repressive Complex 1 ; Repressor Proteins/genetics/isolation & purification/*metabolism ; Ubiquitin/metabolism ; Ubiquitin Thiolesterase/chemistry/genetics/*metabolism ; Ubiquitination/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 65
    facet.materialart.
    Unknown
    Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-07-20
    Description: DNA methylation is one of the best-characterized epigenetic modifications. Although the enzymes that catalyse DNA methylation have been characterized, enzymes responsible for demethylation have been elusive. A recent study indicates that the human TET1 protein could catalyse the conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC), raising the possibility that DNA demethylation may be a Tet1-mediated process. Here we extend this study by demonstrating that all three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse a similar reaction. Tet1 has an important role in mouse embryonic stem (ES) cell maintenance through maintaining the expression of Nanog in ES cells. Downregulation of Nanog via Tet1 knockdown correlates with methylation of the Nanog promoter, supporting a role for Tet1 in regulating DNA methylation status. Furthermore, knockdown of Tet1 in pre-implantation embryos results in a bias towards trophectoderm differentiation. Thus, our studies not only uncover the enzymatic activity of the Tet proteins, but also demonstrate a role for Tet1 in ES cell maintenance and inner cell mass cell specification.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491567/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491567/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Shinsuke -- D'Alessio, Ana C -- Taranova, Olena V -- Hong, Kwonho -- Sowers, Lawrence C -- Zhang, Yi -- CA084487/CA/NCI NIH HHS/ -- GM68804/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Aug 26;466(7310):1129-33. doi: 10.1038/nature09303.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20639862" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/*metabolism ; Alkaline Phosphatase/metabolism ; Animals ; Blastocyst Inner Cell Mass/*metabolism ; Cell Proliferation ; Cytosine/*analogs & derivatives/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Embryonic Stem Cells/*cytology ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Homeodomain Proteins/metabolism ; Mice ; Proto-Oncogene Proteins/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 66
    facet.materialart.
    Unknown
    Competition drives cooperation among closely related sperm of deer mice (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-22
    Description: Among the extraordinary adaptations driven by sperm competition is the cooperative behaviour of spermatozoa. By forming cooperative groups, sperm can increase their swimming velocity and thereby gain an advantage in intermale sperm competition. Accordingly, selection should favour cooperation of the most closely related sperm to maximize fitness. Here we show that sperm of deer mice (genus Peromyscus) form motile aggregations, then we use this system to test predictions of sperm cooperation. We find that sperm aggregate more often with conspecific than heterospecific sperm, suggesting that individual sperm can discriminate on the basis of genetic relatedness. Next, we provide evidence that the cooperative behaviour of closely related sperm is driven by sperm competition. In a monogamous species lacking sperm competition, Peromyscus polionotus, sperm indiscriminately group with unrelated conspecific sperm. In contrast, in the highly promiscuous deer mouse, Peromyscus maniculatus, sperm are significantly more likely to aggregate with those obtained from the same male than with sperm from an unrelated conspecific donor. Even when we test sperm from sibling males, we continue to see preferential aggregations of related sperm in P. maniculatus. These results suggest that sperm from promiscuous deer mice discriminate among relatives and thereby cooperate with the most closely related sperm, an adaptation likely to have been driven by sperm competition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824558/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824558/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, Heidi S -- Hoekstra, Hopi E -- F32 GM084719/GM/NIGMS NIH HHS/ -- F32 GM084719-02/GM/NIGMS NIH HHS/ -- England -- Nature. 2010 Feb 11;463(7282):801-3. doi: 10.1038/nature08736. Epub 2010 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Cambridge, Massachusetts 02138, USA. hfisher@oeb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20090679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Aggregation ; Competitive Behavior/*physiology ; *Cooperative Behavior ; Copulation/physiology ; Female ; Male ; Peromyscus/*classification/*physiology ; Sexual Behavior, Animal/*physiology ; Species Specificity ; Sperm Motility/physiology ; Spermatozoa/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 67
    facet.materialart.
    Unknown
    Vision: Fisheye views (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lincoln, Tim -- England -- Nature. 2010 Apr 15;464(7291):990. doi: 10.1038/464990a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393551" target="_blank"〉PubMed〈/a〉
    Keywords: Air ; Animals ; Perciformes/anatomy & histology/*physiology ; Predatory Behavior/physiology ; Retina/anatomy & histology/*physiology ; Rivers ; Vision, Ocular/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 68
    facet.materialart.
    Unknown
    Regulation of myeloid leukaemia by the cell-fate determinant Musashi (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-07-20
    Description: Chronic myelogenous leukaemia (CML) can progress from a slow growing chronic phase to an aggressive blast crisis phase, but the molecular basis of this transition remains poorly understood. Here we have used mouse models of CML to show that disease progression is regulated by the Musashi-Numb signalling axis. Specifically, we find that the chronic phase is marked by high levels of Numb expression whereas the blast crisis phase has low levels of Numb expression, and that ectopic expression of Numb promotes differentiation and impairs advanced-phase disease in vivo. As a possible explanation for the decreased levels of Numb in the blast crisis phase, we show that NUP98-HOXA9, an oncogene associated with blast crisis CML, can trigger expression of the RNA-binding protein Musashi2 (Msi2), which in turn represses Numb. Notably, loss of Msi2 restores Numb expression and significantly impairs the development and propagation of blast crisis CML in vitro and in vivo. Finally we show that Msi2 expression is not only highly upregulated during human CML progression but is also an early indicator of poorer prognosis. These data show that the Musashi-Numb pathway can control the differentiation of CML cells, and raise the possibility that targeting this pathway may provide a new strategy for the therapy of aggressive leukaemias.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918284/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918284/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Takahiro -- Kwon, Hyog Young -- Zimdahl, Bryan -- Congdon, Kendra L -- Blum, Jordan -- Lento, William E -- Zhao, Chen -- Lagoo, Anand -- Gerrard, Gareth -- Foroni, Letizia -- Goldman, John -- Goh, Harriet -- Kim, Soo-Hyun -- Kim, Dong-Wook -- Chuah, Charles -- Oehler, Vivian G -- Radich, Jerald P -- Jordan, Craig T -- Reya, Tannishtha -- AI067798/AI/NIAID NIH HHS/ -- CA122206/CA/NCI NIH HHS/ -- CA140371/CA/NCI NIH HHS/ -- CA18029/CA/NCI NIH HHS/ -- DK072234/DK/NIDDK NIH HHS/ -- DK63031/DK/NIDDK NIH HHS/ -- DP1 CA174422/CA/NCI NIH HHS/ -- DP1 OD006430/OD/NIH HHS/ -- DP1 OD006430-01/OD/NIH HHS/ -- DP1 OD006430-02/OD/NIH HHS/ -- DP1OD006430/OD/NIH HHS/ -- HL097767/HL/NHLBI NIH HHS/ -- P01 CA018029/CA/NCI NIH HHS/ -- R01 CA140371/CA/NCI NIH HHS/ -- R01 DK063031/DK/NIDDK NIH HHS/ -- R01 DK063031-01/DK/NIDDK NIH HHS/ -- R01 DK063031-01S1/DK/NIDDK NIH HHS/ -- R01 DK063031-02/DK/NIDDK NIH HHS/ -- R01 DK063031-03/DK/NIDDK NIH HHS/ -- R01 DK063031-04/DK/NIDDK NIH HHS/ -- R01 DK063031-05/DK/NIDDK NIH HHS/ -- R01 DK063031-06/DK/NIDDK NIH HHS/ -- R01 DK063031-07/DK/NIDDK NIH HHS/ -- R01 DK063031-07S1/DK/NIDDK NIH HHS/ -- R01 DK063031-08/DK/NIDDK NIH HHS/ -- R01 DK072234/DK/NIDDK NIH HHS/ -- R01 DK072234-01A1/DK/NIDDK NIH HHS/ -- R01 DK072234-02/DK/NIDDK NIH HHS/ -- R01 DK072234-03/DK/NIDDK NIH HHS/ -- R01 DK072234-04/DK/NIDDK NIH HHS/ -- R01 HL097767/HL/NHLBI NIH HHS/ -- R01 HL097767-01/HL/NHLBI NIH HHS/ -- R01 HL097767-02/HL/NHLBI NIH HHS/ -- T32 GM007184-33/GM/NIGMS NIH HHS/ -- U19 AI067798/AI/NIAID NIH HHS/ -- U19 AI067798-010006/AI/NIAID NIH HHS/ -- U19 AI067798-020006/AI/NIAID NIH HHS/ -- U19 AI067798-030006/AI/NIAID NIH HHS/ -- U19 AI067798-040006/AI/NIAID NIH HHS/ -- U19 AI067798-050006/AI/NIAID NIH HHS/ -- England -- Nature. 2010 Aug 5;466(7307):765-8. doi: 10.1038/nature09171. Epub 2010 Jul 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20639863" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blast Crisis/genetics/metabolism/pathology ; *Cell Differentiation/genetics ; Disease Progression ; Fusion Proteins, bcr-abl/genetics/metabolism ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics/metabolism ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/*metabolism/*pathology ; Membrane Proteins/biosynthesis/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/biosynthesis/genetics/metabolism ; Nuclear Pore Complex Proteins/genetics/metabolism ; Oncogene Proteins, Fusion/genetics/metabolism ; Prognosis ; RNA-Binding Proteins/biosynthesis/genetics/*metabolism ; Receptor, Notch1/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 69
    facet.materialart.
    Unknown
    The sequencers (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chi, Kelly Rae -- England -- Nature. 2010 May 13;465(7295):256-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20549837" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Genome/genetics ; Genomics/economics/instrumentation/*manpower/*trends ; Humans ; Sequence Analysis, DNA/economics/instrumentation/statistics & numerical ; data/trends ; Software ; Viruses/genetics/isolation & purification
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 70
    facet.materialart.
    Unknown
    Thousands of chemical starting points for antimalarial lead identification (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-21
    Description: Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline's chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 microM concentration. More than 8,000 also showed potent activity against the multidrug resistant strain Dd2. Most (82%) compounds originate from internal company projects and are new to the malaria community. Analyses using historic assay data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host-pathogen interaction related targets. Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gamo, Francisco-Javier -- Sanz, Laura M -- Vidal, Jaume -- de Cozar, Cristina -- Alvarez, Emilio -- Lavandera, Jose-Luis -- Vanderwall, Dana E -- Green, Darren V S -- Kumar, Vinod -- Hasan, Samiul -- Brown, James R -- Peishoff, Catherine E -- Cardon, Lon R -- Garcia-Bustos, Jose F -- England -- Nature. 2010 May 20;465(7296):305-10. doi: 10.1038/nature09107.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485427" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*analysis/chemistry/*pharmacology/toxicity ; Cell Line, Tumor ; *Drug Discovery ; Drug Resistance, Multiple/drug effects ; Humans ; Malaria, Falciparum/*drug therapy/parasitology ; Models, Biological ; Phylogeny ; Plasmodium falciparum/*drug effects/enzymology/genetics/growth & development ; Small Molecule Libraries/*analysis/chemistry/*pharmacology/toxicity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 71
    facet.materialart.
    Unknown
    Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-14
    Description: The main reason why tumours are not controlled by the immune system is that, unlike pathogens, they do not express potent tumour rejection antigens (TRAs). Tumour vaccination aims at stimulating a systemic immune response targeted to, mostly weak, antigens expressed in the disseminated tumour lesions. Main challenges in developing effective vaccination protocols are the identification of potent and broadly expressed TRAs and effective adjuvants to stimulate a robust and durable immune response. Here we describe an alternative approach in which the expression of new, and thereby potent, antigens are induced in tumour cells by inhibiting nonsense-mediated messenger RNA decay (NMD). Small interfering RNA (siRNA)-mediated inhibition of NMD in tumour cells led to the expression of new antigenic determinants and their immune-mediated rejection. In subcutaneous and metastatic tumour models, tumour-targeted delivery of NMD factor-specific siRNAs conjugated to oligonucleotide aptamer ligands led to significant inhibition of tumour growth that was superior to that of vaccination with granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing irradiated tumour cells, and could be further enhanced by co-stimulation. Tumour-targeted NMD inhibition forms the basis of a simple, broadly useful, and clinically feasible approach to enhance the antigenicity of disseminated tumours leading to their immune recognition and rejection. The cell-free chemically synthesized oligonucleotide backbone of aptamer-siRNAs reduces the risk of immunogenicity and enhances the feasibility of generating reagents suitable for clinical use.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107067/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107067/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pastor, Fernando -- Kolonias, Despina -- Giangrande, Paloma H -- Gilboa, Eli -- R01 CA138503/CA/NCI NIH HHS/ -- R01 CA151857-02/CA/NCI NIH HHS/ -- England -- Nature. 2010 May 13;465(7295):227-30. doi: 10.1038/nature08999.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology & Immunology, Dodson Interdisciplinary Immunotherapy Institute, University of Miami Miller School of Medicine Miami, Florida 33134, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20463739" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/*genetics/*immunology ; Aptamers, Nucleotide/genetics ; Cancer Vaccines/genetics/immunology/metabolism ; Carrier Proteins/genetics ; Cell Line, Tumor ; Chickens/genetics ; Colonic Neoplasms/*genetics/*immunology/pathology ; Gene Expression Regulation, Neoplastic ; Granulocyte-Macrophage Colony-Stimulating Factor/genetics/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Neoplasm Transplantation ; RNA Interference ; RNA Stability/*genetics ; RNA, Small Interfering/*genetics/therapeutic use ; Xenograft Model Antitumor Assays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 72
    facet.materialart.
    Unknown
    Neuroscience: Sexy circuits (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benton, Richard -- England -- Nature. 2010 Dec 2;468(7324):638-40. doi: 10.1038/468638a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21124442" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates/pharmacology ; Animals ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/anatomy & histology/*cytology/*drug effects/physiology ; Female ; Gene Expression Regulation ; Male ; Nerve Tissue Proteins/genetics/metabolism ; Neuroanatomical Tract-Tracing Techniques/methods ; Oleic Acids/pharmacology ; Olfactory Pathways/anatomy & histology/cytology/*drug effects ; Olfactory Perception/drug effects/physiology ; Pheromones/*pharmacology ; Sensory Receptor Cells/drug effects/physiology ; *Sex Characteristics ; Sexual Behavior, Animal/physiology ; Transcription Factors/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 73
    facet.materialart.
    Unknown
    Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-12-03
    Description: The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance and regeneration is central to normal development and ageing, and to organismal survival during periods of acute stress. How energy metabolism and stem-cell homeostatic processes are coordinated is not well understood. Lkb1 acts as an evolutionarily conserved regulator of cellular energy metabolism in eukaryotic cells and functions as the major upstream kinase to phosphorylate AMP-activated protein kinase (AMPK) and 12 other AMPK-related kinases. Whether Lkb1 regulates stem-cell maintenance remains unknown. Here we show that Lkb1 has an essential role in haematopoietic stem cell (HSC) homeostasis. We demonstrate that ablation of Lkb1 in adult mice results in severe pancytopenia and subsequent lethality. Loss of Lkb1 leads to impaired survival and escape from quiescence of HSCs, resulting in exhaustion of the HSC pool and a marked reduction of HSC repopulating potential in vivo. Lkb1 deletion has an impact on cell proliferation in HSCs, but not on more committed compartments, pointing to context-specific functions for Lkb1 in haematopoiesis. The adverse impact of Lkb1 deletion on haematopoiesis was predominantly cell-autonomous and mTOR complex 1 (mTORC1)-independent, and involves multiple mechanisms converging on mitochondrial apoptosis and possibly downregulation of PGC-1 coactivators and their transcriptional network, which have critical roles in mitochondrial biogenesis and function. Thus, Lkb1 serves as an essential regulator of HSCs and haematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem-cell homeostasis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058342/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058342/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gan, Boyi -- Hu, Jian -- Jiang, Shan -- Liu, Yingchun -- Sahin, Ergun -- Zhuang, Li -- Fletcher-Sananikone, Eliot -- Colla, Simona -- Wang, Y Alan -- Chin, Lynda -- Depinho, Ronald A -- 01CA141508/CA/NCI NIH HHS/ -- R21 CA135057/CA/NCI NIH HHS/ -- R21 CA135057-01/CA/NCI NIH HHS/ -- R21CA135057/CA/NCI NIH HHS/ -- U01 CA141508/CA/NCI NIH HHS/ -- U01 CA141508-01/CA/NCI NIH HHS/ -- England -- Nature. 2010 Dec 2;468(7324):701-4. doi: 10.1038/nature09595.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21124456" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Cell Cycle/*physiology ; Cell Proliferation ; Cell Survival ; *Energy Metabolism ; Female ; Gene Deletion ; Hematopoiesis ; Hematopoietic Stem Cells/*cytology/*metabolism/pathology ; *Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism/pathology ; Multiprotein Complexes ; Pancytopenia/genetics ; Phenotype ; Protein-Serine-Threonine Kinases/deficiency/genetics/*metabolism ; Proteins/metabolism ; Survival Analysis ; TOR Serine-Threonine Kinases ; Transcription Factors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 74
    facet.materialart.
    Unknown
    Blood-vessel formation: Bridges that guide and unite (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, Thomas -- Carmeliet, Peter -- England -- Nature. 2010 Jun 10;465(7299):697-9. doi: 10.1038/465697a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Vessels/*cytology/*growth & development ; Cell Fusion ; Endothelial Cells/*cytology/physiology ; Macrophages/*cytology/*physiology ; Neovascularization, Pathologic/pathology/physiopathology ; Neovascularization, Physiologic/*physiology ; Pseudopodia/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 75
    facet.materialart.
    Unknown
    The killing fields (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 Sep 23;467(7314):368. doi: 10.1038/467368a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864950" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*methods ; Animals ; Cattle ; Disease Reservoirs/microbiology/*statistics & numerical data/*veterinary ; *Federal Government ; Great Britain/epidemiology ; *Mustelidae/microbiology ; Reproducibility of Results ; Tuberculosis Vaccines ; Tuberculosis, Bovine/epidemiology/*prevention & control/transmission ; Vaccination/veterinary
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 76
    facet.materialart.
    Unknown
    Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-19
    Description: Influenza A virus, being responsible for seasonal epidemics and reoccurring pandemics, represents a worldwide threat to public health. High mutation rates facilitate the generation of viral escape mutants, rendering vaccines and drugs directed against virus-encoded targets potentially ineffective. In contrast, targeting host cell determinants temporarily dispensable for the host but crucial for virus replication could prevent viral escape. Here we report the discovery of 287 human host cell genes influencing influenza A virus replication in a genome-wide RNA interference (RNAi) screen. Using an independent assay we confirmed 168 hits (59%) inhibiting either the endemic H1N1 (119 hits) or the current pandemic swine-origin (121 hits) influenza A virus strains, with an overlap of 60%. Notably, a subset of these common hits was also essential for replication of a highly pathogenic avian H5N1 strain. In-depth analyses of several factors provided insights into their infection stage relevance. Notably, SON DNA binding protein (SON) was found to be important for normal trafficking of influenza virions to late endosomes early in infection. We also show that a small molecule inhibitor of CDC-like kinase 1 (CLK1) reduces influenza virus replication by more than two orders of magnitude, an effect connected with impaired splicing of the viral M2 messenger RNA. Furthermore, influenza-virus-infected p27(-/-) (cyclin-dependent kinase inhibitor 1B; Cdkn1b) mice accumulated significantly lower viral titres in the lung, providing in vivo evidence for the importance of this gene. Thus, our results highlight the potency of genome-wide RNAi screening for the dissection of virus-host interactions and the identification of drug targets for a broad range of influenza viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karlas, Alexander -- Machuy, Nikolaus -- Shin, Yujin -- Pleissner, Klaus-Peter -- Artarini, Anita -- Heuer, Dagmar -- Becker, Daniel -- Khalil, Hany -- Ogilvie, Lesley A -- Hess, Simone -- Maurer, Andre P -- Muller, Elke -- Wolff, Thorsten -- Rudel, Thomas -- Meyer, Thomas F -- England -- Nature. 2010 Feb 11;463(7282):818-22. doi: 10.1038/nature08760. Epub 2010 Jan 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biology Department, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20081832" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Factors/genetics/metabolism ; Cell Line ; Cells, Cultured ; Chick Embryo ; Cyclin-Dependent Kinase Inhibitor p27/deficiency/genetics/metabolism ; Epithelial Cells/virology ; Genome, Human/genetics ; *Host-Pathogen Interactions/genetics/physiology ; Humans ; Influenza A Virus, H1N1 Subtype/classification/*growth & development ; Influenza, Human/*genetics/*virology ; Lung/cytology ; Mice ; Mice, Inbred C57BL ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; *RNA Interference ; Virus Replication/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 77
    facet.materialart.
    Unknown
    Origin of the human malaria parasite Plasmodium falciparum in gorillas (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-25
    Description: Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting humans, yet the origin and evolutionary history of this important pathogen remain controversial. Here we develop a single-genome amplification strategy to identify and characterize Plasmodium spp. DNA sequences in faecal samples from wild-living apes. Among nearly 3,000 specimens collected from field sites throughout central Africa, we found Plasmodium infection in chimpanzees (Pan troglodytes) and western gorillas (Gorilla gorilla), but not in eastern gorillas (Gorilla beringei) or bonobos (Pan paniscus). Ape plasmodial infections were highly prevalent, widely distributed and almost always made up of mixed parasite species. Analysis of more than 1,100 mitochondrial, apicoplast and nuclear gene sequences from chimpanzees and gorillas revealed that 99% grouped within one of six host-specific lineages representing distinct Plasmodium species within the subgenus Laverania. One of these from western gorillas comprised parasites that were nearly identical to P. falciparum. In phylogenetic analyses of full-length mitochondrial sequences, human P. falciparum formed a monophyletic lineage within the gorilla parasite radiation. These findings indicate that P. falciparum is of gorilla origin and not of chimpanzee, bonobo or ancient human origin.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997044/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997044/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Weimin -- Li, Yingying -- Learn, Gerald H -- Rudicell, Rebecca S -- Robertson, Joel D -- Keele, Brandon F -- Ndjango, Jean-Bosco N -- Sanz, Crickette M -- Morgan, David B -- Locatelli, Sabrina -- Gonder, Mary K -- Kranzusch, Philip J -- Walsh, Peter D -- Delaporte, Eric -- Mpoudi-Ngole, Eitel -- Georgiev, Alexander V -- Muller, Martin N -- Shaw, George M -- Peeters, Martine -- Sharp, Paul M -- Rayner, Julian C -- Hahn, Beatrice H -- P30 AI 7767/AI/NIAID NIH HHS/ -- P30 AI027767/AI/NIAID NIH HHS/ -- P30 AI027767-21A1/AI/NIAID NIH HHS/ -- R01 AI058715/AI/NIAID NIH HHS/ -- R01 AI058715-06A1/AI/NIAID NIH HHS/ -- R01 AI058715-07/AI/NIAID NIH HHS/ -- R01 AI50529/AI/NIAID NIH HHS/ -- R01 I58715/PHS HHS/ -- R03 AI074778/AI/NIAID NIH HHS/ -- R03 AI074778-02/AI/NIAID NIH HHS/ -- R37 AI050529/AI/NIAID NIH HHS/ -- R37 AI050529-07/AI/NIAID NIH HHS/ -- R37 AI050529-08/AI/NIAID NIH HHS/ -- T32 AI007245/AI/NIAID NIH HHS/ -- T32 AI007245-26/AI/NIAID NIH HHS/ -- T32 GM008111/GM/NIGMS NIH HHS/ -- T32 GM008111-13/GM/NIGMS NIH HHS/ -- U19 AI 067854/AI/NIAID NIH HHS/ -- U19 AI067854/AI/NIAID NIH HHS/ -- U19 AI067854-06/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 Sep 23;467(7314):420-5. doi: 10.1038/nature09442.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864995" target="_blank"〉PubMed〈/a〉
    Keywords: Africa/epidemiology ; Animals ; Animals, Wild/classification/parasitology ; Ape Diseases/epidemiology/*parasitology/transmission ; DNA, Mitochondrial/analysis/genetics ; Evolution, Molecular ; Feces/parasitology ; Genes, Mitochondrial/genetics ; Genetic Variation/genetics ; Genome, Protozoan/genetics ; Gorilla gorilla/classification/*parasitology ; Humans ; Malaria, Falciparum/epidemiology/*parasitology/transmission/*veterinary ; Molecular Sequence Data ; Pan paniscus/parasitology ; Pan troglodytes/parasitology ; Phylogeny ; Plasmodium/classification/genetics/isolation & purification ; Plasmodium falciparum/genetics/*isolation & purification ; Prevalence ; Zoonoses/parasitology/transmission
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 78
    facet.materialart.
    Unknown
    Biopiracy rules should not block biological control (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cock, Matthew -- England -- Nature. 2010 Sep 23;467(7314):369. doi: 10.1038/467369a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CABI, Delemont, Switzerland. m.cock@cabi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864952" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; International Cooperation/*legislation & jurisprudence ; Manihot ; Pest Control, Biological/economics/*legislation & jurisprudence ; South America ; Theft/*legislation & jurisprudence ; United States ; Wasps
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 79
    facet.materialart.
    Unknown
    A bony connection signals laryngeal echolocation in bats (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-26
    Description: Echolocation is an active form of orientation in which animals emit sounds and then listen to reflected echoes of those sounds to form images of their surroundings in their brains. Although echolocation is usually associated with bats, it is not characteristic of all bats. Most echolocating bats produce signals in the larynx, but within one family of mainly non-echolocating species (Pteropodidae), a few species use echolocation sounds produced by tongue clicks. Here we demonstrate, using data obtained from micro-computed tomography scans of 26 species (n = 35 fluid-preserved bats), that proximal articulation of the stylohyal bone (part of the mammalian hyoid apparatus) with the tympanic bone always distinguishes laryngeally echolocating bats from all other bats (that is, non-echolocating pteropodids and those that echolocate with tongue clicks). In laryngeally echolocating bats, the proximal end of the stylohyal bone directly articulates with the tympanic bone and is often fused with it. Previous research on the morphology of the stylohyal bone in the oldest known fossil bat (Onychonycteris finneyi) suggested that it did not echolocate, but our findings suggest that O. finneyi may have used laryngeal echolocation because its stylohyal bones may have articulated with its tympanic bones. The present findings reopen basic questions about the timing and the origin of flight and echolocation in the early evolution of bats. Our data also provide an independent anatomical character by which to distinguish laryngeally echolocating bats from other bats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veselka, Nina -- McErlain, David D -- Holdsworth, David W -- Eger, Judith L -- Chhem, Rethy K -- Mason, Matthew J -- Brain, Kirsty L -- Faure, Paul A -- Fenton, M Brock -- MOP-89852/Canadian Institutes of Health Research/Canada -- England -- Nature. 2010 Feb 18;463(7283):939-42. doi: 10.1038/nature08737. Epub 2010 Jan 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Robarts Research Institute.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20098413" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Bone Conduction/*physiology ; Bone and Bones/anatomy & histology/*physiology ; Chiroptera/*anatomy & histology/classification/*physiology ; Ear/anatomy & histology/physiology ; Echolocation/*physiology ; Flight, Animal/physiology ; Fossils ; Larynx/*physiology ; Orientation/physiology ; Skull/anatomy & histology/physiology ; Tongue/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 80
    facet.materialart.
    Unknown
    Enzyme-inhibitor-like tuning of Ca(2+) channel connectivity with calmodulin (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-02-09
    Description: Ca(2+) channels and calmodulin (CaM) are two prominent signalling hubs that synergistically affect functions as diverse as cardiac excitability, synaptic plasticity and gene transcription. It is therefore fitting that these hubs are in some sense coordinated, as the opening of Ca(V)1-2 Ca(2+) channels are regulated by a single CaM constitutively complexed with channels. The Ca(2+)-free form of CaM (apoCaM) is already pre-associated with the isoleucine-glutamine (IQ) domain on the channel carboxy terminus, and subsequent Ca(2+) binding to this 'resident' CaM drives conformational changes that then trigger regulation of channel opening. Another potential avenue for channel-CaM coordination could arise from the absence of Ca(2+) regulation in channels lacking a pre-associated CaM. Natural fluctuations in CaM concentrations might then influence the fraction of regulable channels and, thereby, the overall strength of Ca(2+) feedback. However, the prevailing view has been that the ultrastrong affinity of channels for apoCaM ensures their saturation with CaM, yielding a significant form of concentration independence between Ca(2+) channels and CaM. Here we show that significant exceptions to this autonomy exist, by combining electrophysiology (to characterize channel regulation) with optical fluorescence resonance energy transfer (FRET) sensor determination of free-apoCaM concentration in live cells. This approach translates quantitative CaM biochemistry from the traditional test-tube context into the realm of functioning holochannels within intact cells. From this perspective, we find that long splice forms of Ca(V)1.3 and Ca(V)1.4 channels include a distal carboxy tail that resembles an enzyme competitive inhibitor that retunes channel affinity for apoCaM such that natural CaM variations affect the strength of Ca(2+) feedback modulation. Given the ubiquity of these channels, the connection between ambient CaM levels and Ca(2+) entry through channels is broadly significant for Ca(2+) homeostasis. Strategies such as ours promise key advances for the in situ analysis of signalling molecules resistant to in vitro reconstitution, such as Ca(2+) channels.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553577/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553577/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Xiaodong -- Yang, Philemon S -- Yang, Wanjun -- Yue, David T -- P30 DC005211/DC/NIDCD NIH HHS/ -- R01 DC000276/DC/NIDCD NIH HHS/ -- England -- Nature. 2010 Feb 18;463(7283):968-72. doi: 10.1038/nature08766. Epub 2010 Feb 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20139964" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Apoproteins/analysis/metabolism ; Binding, Competitive/drug effects ; Calcium/analysis/metabolism/pharmacology ; Calcium Channel Blockers/*chemistry/*metabolism ; Calcium Channels/*chemistry/genetics/*metabolism ; Calmodulin/analysis/*metabolism ; Cell Line ; Cell Survival ; Electrophysiology ; *Feedback, Physiological ; Fluorescence Resonance Energy Transfer ; Humans ; Protein Structure, Tertiary ; Rats ; Recombinant Fusion Proteins/chemistry/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 81
    facet.materialart.
    Unknown
    Sister chromosome pairing maintains heterozygosity in parthenogenetic lizards (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-02-23
    Description: Although bisexual reproduction has proven to be highly successful, parthenogenetic all-female populations occur frequently in certain taxa, including the whiptail lizards of the genus Aspidoscelis. Allozyme analysis revealed a high degree of fixed heterozygosity in these parthenogenetic species, supporting the view that they originated from hybridization events between related sexual species. It has remained unclear how the meiotic program is altered to produce diploid eggs while maintaining heterozygosity. Here we show that meiosis commences with twice the number of chromosomes in parthenogenetic versus sexual species, a mechanism that provides the basis for generating gametes with unreduced chromosome content without fundamental deviation from the classic meiotic program. Our observation of synaptonemal complexes and chiasmata demonstrate that a typical meiotic program occurs and that heterozygosity is not maintained by bypassing recombination. Instead, fluorescent in situ hybridization probes that distinguish between homologues reveal that bivalents form between sister chromosomes, the genetically identical products of the first of two premeiotic replication cycles. Sister chromosome pairing provides a mechanism for the maintenance of heterozygosity, which is critical for offsetting the reduced fitness associated with the lack of genetic diversity in parthenogenetic species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840635/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840635/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lutes, Aracely A -- Neaves, William B -- Baumann, Diana P -- Wiegraebe, Winfried -- Baumann, Peter -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Mar 11;464(7286):283-6. doi: 10.1038/nature08818. Epub 2010 Feb 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20173738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Pairing/*genetics ; Chromosomes/*genetics ; Crossing Over, Genetic/genetics ; Female ; *Heterozygote ; Lizards/*genetics ; Meiosis/genetics ; Microscopy, Electron, Transmission ; Oocytes/cytology/physiology/ultrastructure ; Telomere/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 82
    facet.materialart.
    Unknown
    Biological imaging: Beyond fluorescence (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Bruce E -- England -- Nature. 2010 Sep 23;467(7314):407-8. doi: 10.1038/467407a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20864989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fluorescence ; Fluorescent Dyes/analysis/chemistry ; Infrared Rays ; Light ; Microscopy/*methods ; Molecular Imaging/*methods ; Nanoparticles/*analysis/*chemistry ; Particle Size ; Photobleaching ; Photons ; Quantum Dots
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 83
    facet.materialart.
    Unknown
    Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-23
    Description: The worldwide prevalence of chronic hepatitis C virus (HCV) infection is estimated to be approaching 200 million people. Current therapy relies upon a combination of pegylated interferon-alpha and ribavirin, a poorly tolerated regimen typically associated with less than 50% sustained virological response rate in those infected with genotype 1 virus. The development of direct-acting antiviral agents to treat HCV has focused predominantly on inhibitors of the viral enzymes NS3 protease and the RNA-dependent RNA polymerase NS5B. Here we describe the profile of BMS-790052, a small molecule inhibitor of the HCV NS5A protein that exhibits picomolar half-maximum effective concentrations (EC(50)) towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture. In a phase I clinical trial in patients chronically infected with HCV, administration of a single 100-mg dose of BMS-790052 was associated with a 3.3 log(10) reduction in mean viral load measured 24 h post-dose that was sustained for an additional 120 h in two patients infected with genotype 1b virus. Genotypic analysis of samples taken at baseline, 24 and 144 h post-dose revealed that the major HCV variants observed had substitutions at amino-acid positions identified using the in vitro replicon system. These results provide the first clinical validation of an inhibitor of HCV NS5A, a protein with no known enzymatic function, as an approach to the suppression of virus replication that offers potential as part of a therapeutic regimen based on combinations of HCV inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gao, Min -- Nettles, Richard E -- Belema, Makonen -- Snyder, Lawrence B -- Nguyen, Van N -- Fridell, Robert A -- Serrano-Wu, Michael H -- Langley, David R -- Sun, Jin-Hua -- O'Boyle, Donald R 2nd -- Lemm, Julie A -- Wang, Chunfu -- Knipe, Jay O -- Chien, Caly -- Colonno, Richard J -- Grasela, Dennis M -- Meanwell, Nicholas A -- Hamann, Lawrence G -- England -- Nature. 2010 May 6;465(7294):96-100. doi: 10.1038/nature08960. Epub 2010 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Virology, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20410884" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Antiviral Agents/blood/chemistry/*pharmacology/therapeutic use ; Cell Line ; Cercopithecus aethiops ; Drug Resistance, Viral ; Female ; Genotype ; HeLa Cells ; Hepacivirus/*drug effects ; Hepatitis C/drug therapy/virology ; Humans ; Imidazoles/blood/chemistry/*pharmacology ; Inhibitory Concentration 50 ; Male ; Middle Aged ; Time Factors ; Vero Cells ; Viral Load/drug effects ; Viral Nonstructural Proteins/*antagonists & inhibitors ; Young Adult
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 84
    facet.materialart.
    Unknown
    Evolutionary biology: Oh sibling, who art thou? (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cockburn, Andrew -- England -- Nature. 2010 Aug 19;466(7309):930-1. doi: 10.1038/466930a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20725030" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Birds/classification/genetics/*physiology ; *Cooperative Behavior ; Fathers ; Female ; Male ; Models, Biological ; Mothers ; Phylogeny ; Reproduction/genetics/physiology ; Sexual Behavior, Animal/*physiology ; *Siblings
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 85
    facet.materialart.
    Unknown
    Stem cells: Cues from steroid hormones (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lydon, John P -- England -- Nature. 2010 Jun 10;465(7299):695-6. doi: 10.1038/465695a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535190" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/pathology ; Cell Division ; Estrogens/*metabolism ; Estrous Cycle/physiology ; Female ; Humans ; Lactation/physiology ; Mammary Glands, Animal/*cytology ; Mice ; Paracrine Communication ; Pregnancy ; Pregnancy, Animal/physiology ; Progesterone/*metabolism ; RANK Ligand/metabolism ; Receptors, Estrogen/deficiency ; Receptors, Progesterone/deficiency ; Stem Cell Niche/cytology/metabolism ; Stem Cells/*cytology/drug effects/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 86
    facet.materialart.
    Unknown
    RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-02-25
    Description: Tumours with mutant BRAF are dependent on the RAF-MEK-ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells with mutant BRAF, but unexpectedly enhance signalling in cells with wild-type BRAF. Here we demonstrate the mechanistic basis for these findings. We used chemical genetic methods to show that drug-mediated transactivation of RAF dimers is responsible for paradoxical activation of the enzyme by inhibitors. Induction of ERK signalling requires direct binding of the drug to the ATP-binding site of one kinase of the dimer and is dependent on RAS activity. Drug binding to one member of RAF homodimers (CRAF-CRAF) or heterodimers (CRAF-BRAF) inhibits one protomer, but results in transactivation of the drug-free protomer. In BRAF(V600E) tumours, RAS is not activated, thus transactivation is minimal and ERK signalling is inhibited in cells exposed to RAF inhibitors. These results indicate that RAF inhibitors will be effective in tumours in which BRAF is mutated. Furthermore, because RAF inhibitors do not inhibit ERK signalling in other cells, the model predicts that they would have a higher therapeutic index and greater antitumour activity than mitogen-activated protein kinase (MEK) inhibitors, but could also cause toxicity due to MEK/ERK activation. These predictions have been borne out in a recent clinical trial of the RAF inhibitor PLX4032 (refs 4, 5). The model indicates that promotion of RAF dimerization by elevation of wild-type RAF expression or RAS activity could lead to drug resistance in mutant BRAF tumours. In agreement with this prediction, RAF inhibitors do not inhibit ERK signalling in cells that coexpress BRAF(V600E) and mutant RAS.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178447/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178447/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poulikakos, Poulikos I -- Zhang, Chao -- Bollag, Gideon -- Shokat, Kevan M -- Rosen, Neal -- 1P01CA129243-02/CA/NCI NIH HHS/ -- 2R01EB001987/EB/NIBIB NIH HHS/ -- P01 CA129243-010002/CA/NCI NIH HHS/ -- R01 EB001987/EB/NIBIB NIH HHS/ -- U01 CA091178/CA/NCI NIH HHS/ -- U01 CA091178-01/CA/NCI NIH HHS/ -- England -- Nature. 2010 Mar 18;464(7287):427-30. doi: 10.1038/nature08902.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20179705" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Catalytic Domain ; Cell Line ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Extracellular Signal-Regulated MAP Kinases/*metabolism ; Humans ; Indoles/pharmacology ; MAP Kinase Signaling System/*drug effects ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Models, Biological ; Neoplasms/drug therapy/enzymology/genetics/metabolism ; Phosphorylation ; Protein Binding ; Protein Kinase Inhibitors/metabolism/*pharmacology/therapeutic use ; Protein Multimerization ; Proto-Oncogene Proteins B-raf/antagonists & ; inhibitors/chemistry/genetics/*metabolism ; Sulfonamides/pharmacology ; Transcriptional Activation/*drug effects ; raf Kinases/*antagonists & inhibitors/chemistry/genetics/*metabolism ; ras Proteins/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 87
    facet.materialart.
    Unknown
    Environmental science: new life for the Dead Sea? (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glausiusz, Josie -- England -- Nature. 2010 Apr 22;464(7292):1118-20. doi: 10.1038/4641118a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20414284" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; Animals ; Desert Climate ; *Ecosystem ; Eutrophication ; Fresh Water/*analysis/chemistry/microbiology ; Indian Ocean ; International Cooperation ; Middle East ; Salinity ; Volatilization ; *Water Supply/analysis/economics/statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 88
    facet.materialart.
    Unknown
    Still prime time for primates (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2010 May 20;465(7296):267. doi: 10.1038/465267a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485389" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Rights/trends ; Animals ; Animals, Laboratory/anatomy & histology/physiology ; Cognition/*physiology ; Empathy/physiology ; Humans ; Mice ; *Models, Animal ; Neurosciences/*methods/trends ; Prefrontal Cortex/anatomy & histology/physiology ; Primates/*anatomy & histology/*physiology ; Rats
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 89
    facet.materialart.
    Unknown
    Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-22
    Description: The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and night. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis, and although rhythmic control of insulin release is recognized to be dysregulated in humans with diabetes, it is not known how the circadian clock may affect this process. Here we show that pancreatic islets possess self-sustained circadian gene and protein oscillations of the transcription factors CLOCK and BMAL1. The phase of oscillation of islet genes involved in growth, glucose metabolism and insulin signalling is delayed in circadian mutant mice, and both Clock and Bmal1 (also called Arntl) mutants show impaired glucose tolerance, reduced insulin secretion and defects in size and proliferation of pancreatic islets that worsen with age. Clock disruption leads to transcriptome-wide alterations in the expression of islet genes involved in growth, survival and synaptic vesicle assembly. Notably, conditional ablation of the pancreatic clock causes diabetes mellitus due to defective beta-cell function at the very latest stage of stimulus-secretion coupling. These results demonstrate a role for the beta-cell clock in coordinating insulin secretion with the sleep-wake cycle, and reveal that ablation of the pancreatic clock can trigger the onset of diabetes mellitus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920067/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920067/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcheva, Biliana -- Ramsey, Kathryn Moynihan -- Buhr, Ethan D -- Kobayashi, Yumiko -- Su, Hong -- Ko, Caroline H -- Ivanova, Ganka -- Omura, Chiaki -- Mo, Shelley -- Vitaterna, Martha H -- Lopez, James P -- Philipson, Louis H -- Bradfield, Christopher A -- Crosby, Seth D -- JeBailey, Lellean -- Wang, Xiaozhong -- Takahashi, Joseph S -- Bass, Joseph -- P01 AG011412/AG/NIA NIH HHS/ -- P01 AG011412-080011/AG/NIA NIH HHS/ -- R01 HL097817/HL/NHLBI NIH HHS/ -- R01 HL097817-01/HL/NHLBI NIH HHS/ -- R37 ES005703/ES/NIEHS NIH HHS/ -- R37-ES-005703/ES/NIEHS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Jul 29;466(7306):627-31. doi: 10.1038/nature09253.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20562852" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/deficiency/*genetics/metabolism ; Aging/genetics/pathology ; Animals ; Blood Glucose/analysis/metabolism ; CLOCK Proteins/deficiency/*genetics/metabolism ; Cell Proliferation ; Cell Size ; Cell Survival ; Circadian Rhythm/genetics/*physiology ; Diabetes Mellitus/genetics/*metabolism ; Gene Expression Profiling ; Glucose Intolerance/genetics ; Glucose Tolerance Test ; In Vitro Techniques ; Insulin/*blood/metabolism/secretion ; Islets of Langerhans/*metabolism/pathology/secretion ; Mice ; Period Circadian Proteins/genetics/metabolism ; Phenotype ; Sleep/genetics/physiology ; Synaptic Vesicles/metabolism ; Wakefulness/genetics/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 90
    facet.materialart.
    Unknown
    Direct conversion of fibroblasts to functional neurons by defined factors (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-29
    Description: Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829121/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829121/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vierbuchen, Thomas -- Ostermeier, Austin -- Pang, Zhiping P -- Kokubu, Yuko -- Sudhof, Thomas C -- Wernig, Marius -- 1018438-142-PABCA/PHS HHS/ -- 5T32NS007280/NS/NINDS NIH HHS/ -- T32 CA009302/CA/NCI NIH HHS/ -- U01 HL100397/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Feb 25;463(7284):1035-41. doi: 10.1038/nature08797. Epub 2010 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, California 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20107439" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism ; Biomarkers/analysis ; Cell Line ; *Cell Lineage ; *Cell Transdifferentiation ; Cells, Cultured ; Embryo, Mammalian/cytology ; Fibroblasts/*cytology ; Mice ; Nerve Tissue Proteins/genetics/metabolism ; Neurons/*cytology/metabolism/*physiology ; POU Domain Factors/genetics/metabolism ; Regenerative Medicine ; Synapses/metabolism ; Tail/cytology ; Time Factors ; Transcription Factors/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 91
    facet.materialart.
    Unknown
    High-performance genetically targetable optical neural silencing by light-driven proton pumps (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-08
    Description: The ability to silence the activity of genetically specified neurons in a temporally precise fashion would provide the opportunity to investigate the causal role of specific cell classes in neural computations, behaviours and pathologies. Here we show that members of the class of light-driven outward proton pumps can mediate powerful, safe, multiple-colour silencing of neural activity. The gene archaerhodopsin-3 (Arch) from Halorubrum sodomense enables near-100% silencing of neurons in the awake brain when virally expressed in the mouse cortex and illuminated with yellow light. Arch mediates currents of several hundred picoamps at low light powers, and supports neural silencing currents approaching 900 pA at light powers easily achievable in vivo. Furthermore, Arch spontaneously recovers from light-dependent inactivation, unlike light-driven chloride pumps that enter long-lasting inactive states in response to light. These properties of Arch are appropriate to mediate the optical silencing of significant brain volumes over behaviourally relevant timescales. Arch function in neurons is well tolerated because pH excursions created by Arch illumination are minimized by self-limiting mechanisms to levels comparable to those mediated by channelrhodopsins or natural spike firing. To highlight how proton pump ecological and genomic diversity may support new innovation, we show that the blue-green light-drivable proton pump from the fungus Leptosphaeria maculans (Mac) can, when expressed in neurons, enable neural silencing by blue light, thus enabling alongside other developed reagents the potential for independent silencing of two neural populations by blue versus red light. Light-driven proton pumps thus represent a high-performance and extremely versatile class of 'optogenetic' voltage and ion modulator, which will broadly enable new neuroscientific, biological, neurological and psychiatric investigations.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939492/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939492/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chow, Brian Y -- Han, Xue -- Dobry, Allison S -- Qian, Xiaofeng -- Chuong, Amy S -- Li, Mingjie -- Henninger, Michael A -- Belfort, Gabriel M -- Lin, Yingxi -- Monahan, Patrick E -- Boyden, Edward S -- 1K99MH085944/MH/NIMH NIH HHS/ -- DP2 OD002002/OD/NIH HHS/ -- DP2 OD002002-01/OD/NIH HHS/ -- K99 MH085944/MH/NIMH NIH HHS/ -- K99 MH085944-01/MH/NIMH NIH HHS/ -- England -- Nature. 2010 Jan 7;463(7277):98-102. doi: 10.1038/nature08652.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The MIT Media Laboratory, Synthetic Neurobiology Group, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20054397" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/radiation effects ; Animals ; Ascomycota/metabolism/radiation effects ; Color ; Electric Conductivity ; Euryarchaeota/metabolism/radiation effects ; Genetic Engineering/*methods ; Hydrogen-Ion Concentration ; Mice ; Molecular Sequence Data ; Neocortex/cytology/physiology/radiation effects ; Neurons/*metabolism/*radiation effects ; Proton Pumps/classification/genetics/*metabolism/*radiation effects ; Rhodopsins, Microbial/antagonists & inhibitors/genetics/metabolism/radiation ; effects ; Wakefulness
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 92
    facet.materialart.
    Unknown
    Literature mining: Speed reading (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lok, Corie -- England -- Nature. 2010 Jan 28;463(7280):416-8. doi: 10.1038/463416a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20110962" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bibliometrics ; Biomedical Research/*statistics & numerical data ; Data Mining/*methods ; Humans ; Online Systems ; *Periodicals as Topic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 93
    facet.materialart.
    Unknown
    Islands champion tuna ban (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pala, Christopher -- England -- Nature. 2010 Dec 9;468(7325):739-40. doi: 10.1038/468739a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21150962" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; Conservation of Natural Resources/*legislation & jurisprudence/methods ; Ecology/legislation & jurisprudence/methods ; Fisheries/*legislation & jurisprudence/*methods ; *Geography ; Hawaii ; *International Cooperation ; Pacific Ocean ; Population Density ; *Tuna/physiology ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 94
    facet.materialart.
    Unknown
    Higher rates of sex evolve in spatially heterogeneous environments (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-15
    Description: The evolution and maintenance of sexual reproduction has puzzled biologists for decades. Although this field is rich in hypotheses, experimental evidence is scarce. Some important experiments have demonstrated differences in evolutionary rates between sexual and asexual populations; other experiments have documented evolutionary changes in phenomena related to genetic mixing, such as recombination and selfing. However, direct experiments of the evolution of sex within populations are extremely rare (but see ref. 12). Here we use the rotifer, Brachionus calyciflorus, which is capable of both sexual and asexual reproduction, to test recent theory predicting that there is more opportunity for sex to evolve in spatially heterogeneous environments. Replicated experimental populations of rotifers were maintained in homogeneous environments, composed of either high- or low-quality food habitats, or in heterogeneous environments that consisted of a mix of the two habitats. For populations maintained in either type of homogeneous environment, the rate of sex evolves rapidly towards zero. In contrast, higher rates of sex evolve in populations experiencing spatially heterogeneous environments. The data indicate that the higher level of sex observed under heterogeneity is not due to sex being less costly or selection against sex being less efficient; rather sex is sufficiently advantageous in heterogeneous environments to overwhelm its inherent costs. Counter to some alternative theories for the evolution of sex, there is no evidence that genetic drift plays any part in the evolution of sex in these populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becks, Lutz -- Agrawal, Aneil F -- England -- Nature. 2010 Nov 4;468(7320):89-92. doi: 10.1038/nature09449. Epub 2010 Oct 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology & Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada. lutz.becks@utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944628" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration/physiology ; Animals ; *Biological Evolution ; Diet/veterinary ; *Ecosystem ; Female ; *Food ; Genetic Drift ; Male ; Meiosis/genetics ; Models, Biological ; Ovum/physiology ; Population Density ; Reproduction/physiology ; Reproduction, Asexual/physiology ; Rotifera/cytology/genetics/*physiology ; Selection, Genetic ; *Sex
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 95
    facet.materialart.
    Unknown
    Immunology and the elusive AIDS vaccine (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-12
    Description: Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this goal is achievable. Natural immunity is not protective, and despite immunogenicity of HIV vaccine candidates, human trials have exclusively yielded disappointing results. Nevertheless, there is an indication that success may be possible, but this will be dependent on understanding the antiviral immune response in unprecedented depth to identify and engineer the types of immunity required. Here we outline fundamental immunological questions that need to be answered to develop a protective HIV vaccine, and the immediate need to harness a much broader scientific community to achieve this goal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Virgin, Herbert W -- Walker, Bruce D -- England -- Nature. 2010 Mar 11;464(7286):224-31. doi: 10.1038/nature08898.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. virgin@wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20220841" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Acquired Immunodeficiency Syndrome/*immunology/prevention & control ; Animals ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; HIV/*immunology ; HIV Antibodies/immunology ; Humans ; Mucous Membrane/immunology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 96
    facet.materialart.
    Unknown
    Extrinsic regulation of pluripotent stem cells (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-11
    Description: During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show that cultured stem-cell lines derived from different stages of mouse development can mimic these transition states. They further reveal that there is a high degree of heterogeneity and plasticity in pluripotent populations in vitro and that these properties are modulated by extrinsic signalling. Understanding the extrinsic control of plasticity will guide efforts to use human pluripotent stem cells in research and therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pera, Martin F -- Tam, Patrick P L -- England -- Nature. 2010 Jun 10;465(7299):713-20. doi: 10.1038/nature09228.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. pera@usc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20535200" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryonic Stem Cells/cytology/metabolism ; Humans ; Leukemia Inhibitory Factor/metabolism ; Pluripotent Stem Cells/*cytology/*physiology ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Wnt Proteins/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 97
    facet.materialart.
    Unknown
    Food: A taste of things to come? (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Nicola -- England -- Nature. 2010 Dec 9;468(7325):752-3. doi: 10.1038/468752a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21150970" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioreactors ; Biotechnology/economics/*methods/*trends ; Chitosan/metabolism ; Conservation of Natural Resources/economics/methods/trends ; Culture Media/chemistry/economics/pharmacology ; Embryonic Stem Cells/cytology ; *Food Supply/economics ; Humans ; Meat/*supply & distribution ; *Muscles/cytology/drug effects ; Organ Culture Techniques/economics/methods/*utilization
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 98
    facet.materialart.
    Unknown
    Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-08-06
    Description: Long interspersed element-1 (LINE-1 or L1) retrotransposition continues to affect human genome evolution. L1s can retrotranspose in the germline, during early development and in select somatic cells; however, the host response to L1 retrotransposition remains largely unexplored. Here we show that reporter genes introduced into the genome of various human embryonic carcinoma-derived cell lines (ECs) by L1 retrotransposition are rapidly and efficiently silenced either during or immediately after their integration. Treating ECs with histone deacetylase inhibitors rapidly reverses this silencing, and chromatin immunoprecipitation experiments revealed that reactivation of the reporter gene was correlated with changes in chromatin status at the L1 integration site. Under our assay conditions, rapid silencing was also observed when reporter genes were delivered into ECs by mouse L1s and a zebrafish LINE-2 element, but not when similar reporter genes were delivered into ECs by Moloney murine leukaemia virus or human immunodeficiency virus, suggesting that these integration events are silenced by distinct mechanisms. Finally, we demonstrate that subjecting ECs to culture conditions that promote differentiation attenuates the silencing of reporter genes delivered by L1 retrotransposition, but that differentiation, in itself, is not sufficient to reactivate previously silenced reporter genes. Thus, our data indicate that ECs differ from many differentiated cells in their ability to silence reporter genes delivered by L1 retrotransposition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034402/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034402/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia-Perez, Jose L -- Morell, Maria -- Scheys, Joshua O -- Kulpa, Deanna A -- Morell, Santiago -- Carter, Christoph C -- Hammer, Gary D -- Collins, Kathleen L -- O'Shea, K Sue -- Menendez, Pablo -- Moran, John V -- 5 P30 CA46592/CA/NCI NIH HHS/ -- GM-069985/GM/NIGMS NIH HHS/ -- GM060518/GM/NIGMS NIH HHS/ -- GM082970/GM/NIGMS NIH HHS/ -- NS-048187/NS/NINDS NIH HHS/ -- R01 DK62027/DK/NIDDK NIH HHS/ -- R01 GM060518/GM/NIGMS NIH HHS/ -- R01 GM060518-12/GM/NIGMS NIH HHS/ -- R01 GM082970/GM/NIGMS NIH HHS/ -- R01 GM082970-04/GM/NIGMS NIH HHS/ -- R01AI051198/AI/NIAID NIH HHS/ -- T32-GM08322/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Aug 5;466(7307):769-73. doi: 10.1038/nature09209.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, 1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA. josel.garcia.perez@juntadeandalucia.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/genetics/physiology ; Cell Line, Tumor ; Chromatin/drug effects/genetics/metabolism ; Chromatin Immunoprecipitation ; Embryonal Carcinoma Stem Cells/*metabolism/pathology ; Epigenesis, Genetic/drug effects/*genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; *Gene Silencing/drug effects ; Genes, Reporter/genetics ; Genetic Engineering ; Genetic Vectors/genetics ; Genome, Human/genetics ; HIV/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Long Interspersed Nucleotide Elements/genetics ; Male ; Mice ; Models, Genetic ; Moloney murine leukemia virus/genetics ; Retroelements/*genetics ; Zebrafish/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 99
    facet.materialart.
    Unknown
    Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-01
    Description: Breast cancer is one of the most common cancers in humans and will on average affect up to one in eight women in their lifetime in the United States and Europe. The Women's Health Initiative and the Million Women Study have shown that hormone replacement therapy is associated with an increased risk of incident and fatal breast cancer. In particular, synthetic progesterone derivatives (progestins) such as medroxyprogesterone acetate (MPA), used in millions of women for hormone replacement therapy and contraceptives, markedly increase the risk of developing breast cancer. Here we show that the in vivo administration of MPA triggers massive induction of the key osteoclast differentiation factor RANKL (receptor activator of NF-kappaB ligand) in mammary-gland epithelial cells. Genetic inactivation of the RANKL receptor RANK in mammary-gland epithelial cells prevents MPA-induced epithelial proliferation, impairs expansion of the CD49f(hi) stem-cell-enriched population, and sensitizes these cells to DNA-damage-induced cell death. Deletion of RANK from the mammary epithelium results in a markedly decreased incidence and delayed onset of MPA-driven mammary cancer. These data show that the RANKL/RANK system controls the incidence and onset of progestin-driven breast cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084017/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084017/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schramek, Daniel -- Leibbrandt, Andreas -- Sigl, Verena -- Kenner, Lukas -- Pospisilik, John A -- Lee, Heather J -- Hanada, Reiko -- Joshi, Purna A -- Aliprantis, Antonios -- Glimcher, Laurie -- Pasparakis, Manolis -- Khokha, Rama -- Ormandy, Christopher J -- Widschwendter, Martin -- Schett, Georg -- Penninger, Josef M -- HD055601/HD/NICHD NIH HHS/ -- R01 HD055601/HD/NICHD NIH HHS/ -- R01 HD055601-04/HD/NICHD NIH HHS/ -- England -- Nature. 2010 Nov 4;468(7320):98-102. doi: 10.1038/nature09387. Epub 2010 Sep 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20881962" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/radiation effects ; Cell Differentiation ; Cell Proliferation/drug effects ; DNA Damage ; Epithelial Cells/cytology/drug effects/metabolism/radiation effects ; Female ; Gamma Rays ; Integrin alpha6/metabolism ; Mammary Neoplasms, Experimental/*chemically ; induced/genetics/metabolism/*pathology ; Medroxyprogesterone Acetate/administration & dosage/adverse effects ; Mice ; NF-kappa B/metabolism ; Osteoclasts/cytology ; Phosphoproteins/analysis/immunology ; Progestins/administration & dosage/*adverse effects ; RANK Ligand/deficiency/genetics/*metabolism ; Receptor Activator of Nuclear Factor-kappa B/deficiency/genetics/metabolism ; Signal Transduction ; Stem Cells/cytology/drug effects/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 100
    facet.materialart.
    Unknown
    Oceanography: Death and rebirth in the deep (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Qiu, Jane -- England -- Nature. 2010 May 20;465(7296):284-6. doi: 10.1038/465284a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485410" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; *Biodiversity ; *Biological Evolution ; Geography ; Hot Springs/microbiology ; Larva/genetics/physiology ; *Marine Biology ; Mexico ; Oceanography ; Oceans and Seas ; Population Dynamics ; *Volcanic Eruptions/adverse effects ; Water Movements
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...