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  • Springer  (211,911)
  • PANGAEA
  • 1975-1979  (212,558)
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Years
Year
  • 1
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2016-07-08
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 2
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2016-08-15
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 3
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2016-08-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 4
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    PANGAEA
    In:  EPIC3Berichte aus dem Institut für Meereskunde, Kiel., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 5
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    PANGAEA
    In:  EPIC3Berichte aus dem Institut für Meereskunde an der Christian-Albrechts-Universität Kiel., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 6
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    PANGAEA
    In:  EPIC3Berichte aus dem Institut für Meereskunde, Kiel, Bremerhaven, PANGAEA, 66, 38 p.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 7
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-12-01
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 8
    Publication Date: 2016-06-20
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 9
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-11-18
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 10
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-11-23
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 11
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-11-23
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 12
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-02-09
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 13
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    PANGAEA
    In:  EPIC3Berichte aus dem Institut für Meereskunde an der Christian-Albrechts-Universität Kiel., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 14
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    PANGAEA
    In:  EPIC3Neue Ausgarbungen und Forschungen in Niedersachsen, Bremerhaven, PANGAEA, 10, pp. 197-224
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 15
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    PANGAEA
    In:  EPIC3Jahrbuch der Geologische Bundesanstalt, Bremerhaven, PANGAEA, 120(1), pp. 131-163
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 16
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    PANGAEA
    In:  EPIC3Nauka, Moscow, Bremerhaven, PANGAEA, 296 p.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 17
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    PANGAEA
    In:  EPIC3Berichte aus dem Institut für Meereskunde, Kiel., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 18
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 19
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 20
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 21
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2014-05-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 22
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-07-15
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 23
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2016-02-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 24
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    PANGAEA
    In:  EPIC3Offa, Berichte und Mitteilungen zur Urgeschichte, Frühgeschichte und Mittelalterarchäologie, Bremerhaven, PANGAEA, 35, pp. 11-35
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 25
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 26
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 27
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 28
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 29
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 30
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 31
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 32
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 33
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 34
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 35
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 36
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 37
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    PANGAEA
    In:  EPIC3Geologisch-Paläontologisches Institut, Christian-Albrechts-Universität, Kiel., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 38
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    PANGAEA
    In:  EPIC3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72(1-2), 248-254, doi:10.1016/0003-2697(76), Bremerhaven, PANGAEA, pp. 90527-3
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 39
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 40
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 41
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Hamburg, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 42
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    PANGAEA
    In:  EPIC3Deutsches Hydrographisches Institut, Deutsche Forschungsgemeinschaft; Harald Boldt Verlag, Boppard, Bremerhaven, PANGAEA, 180 p.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 43
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    PANGAEA
    In:  EPIC3Umschau, Bremerhaven, PANGAEA, 12, pp. 390-39
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 44
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    PANGAEA
    In:  EPIC3Probleme der Küstenforschung im südlichen Nordseegebiet, Bremerhaven, PANGAEA, 11, pp. 101-118
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 45
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    PANGAEA
    In:  EPIC3Berichte aus dem Institut für Meereskunde, Kiel., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 46
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 41 (1979), S. 893-898 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Biological tree-like structures, such as mammalian tracheobronchial airways, are complicated branching systems. One problem in modeling such systems is the reassignment of the number of segments at a given generation in the model being constructed. A hypothesis is proposed which has successfully been used in modeling mammalian lung airways.
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  • 47
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    Springer
    Bulletin of mathematical biology 37 (1975), S. 37-49 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The chromosomal theory of inbreeding based on a gametic interaction system lead us to define a depression coefficientD. Comparison of random, sib and half-sib matings (with inbreeding coefficientF=0, 1/4 and 1/8) shows thatD depends on the structure of the starting population and on values of the model parameters. This result accounts for responses of lines whose depression does not depend directly on the inbreeding coefficient and which theories of inbreeding based on increasing homozygosity fail to explain.
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  • 48
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    Springer
    Bulletin of mathematical biology 37 (1975), S. 59-69 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract An idealization of chemical combination is formulated as a model of computability, and it is shown that this model has universal computational power just in case assembly has at least two-dimensional space in which to occur. It is also shown that this model, under reinterpretation, corresponds to a cellular automaton in which growth occurs by differentiation only (i.e., the state into which any cell is born is thereadfter fixed). Hence this latter model of growth is also computationally universal.
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  • 49
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Kinetics of biological light emission processes do not mean what they seem to mean, because measured light intensity is not proportional to reactant concentration but to reaction rate. Therefore, the differential equation for light decay is usually different from that of concentration decay, so that mass action interpretations cannot be applied directly to light intensity decay. An observed second order light decay for Chlorella at 6.5°C, implies Elovich solid state reaction kinetics, which agrees with other evidence for solid state processes in photosynthesis. An observed 1.5 order light decay for Cholorella at 28°C implies second order liquid or solid state reaction kinetics. First ordere light decay implies first order reaction kinetics.
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  • 50
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    Springer
    Bulletin of mathematical biology 37 (1975), S. 71-78 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Analysis based on the integration of differential inequalities is employed to derive upper and lower bounds on the total populationN(t) = ∫ R θ(x 1,x 2,t) dx 1 dx 2 of a biological species with an area-density distribution function θ=θ(x 1,x 2,t) (≥0) governed by a reaction-diffusion equation of the form ∂θ/∂t =D∇2θ +fθ −gθ n+1 whereD (〉0),n (〉0),f andg are constant parameters, θ=0 at all points on the boundary ∂R of an (arbitrary) two-dimensional regionR, and the initial distribution (θ(x 1,x 2, 0) is such thatN(0) is finite. Forg≥0 withR the entire two-dimensional Euclidean space, a lower bound onN(t) is obtained, showing in particular thatN(∞) is bounded below by a finite positive quantity forf≥0 andn〉1. An upper bound onN(t) is obtained for arbitrary bounded or unbounded)R withn=1,f andg negative, and ∫ R θ(x 1,x 2, 0)2 dx 1 dx 2 sufficiently small in magnitude, implying that the population goes to extinction with increasing values of the time,N(∞)=0. Forg≥0 andR of finite area, the analysis yields upper bounds onN(t), predicting eventual extinction of the population if eitherf≤0 or if the area ofR is less than a certain grouping of the parameters in cases for whichf is positive. These results are directly applicable to biological species with distributions satisfying the Fisher equation in two spatial dimensions and to species governed by certain specialized population models.
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  • 51
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    Bulletin of mathematical biology 37 (1975), S. 127-138 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The equilibrium probability distribution of the process level is studied for a general class of reversible stochastic reactions. A calculationally convenient approximation for equilibrium probabilities is derived and its accuracy is investigated over a range of values of the equilibrium constant. A method of approximating the equilibrium means and variance is developed and illustrated forQ th-order processes.
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  • 52
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    Bulletin of mathematical biology 37 (1975), S. 565-572 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Beside the concept of material inputs and outputs of components of the representation of biological systems given to us by Rosen, the concept of energy is incorporated. The interaction of material and energy is represented by a cartesian product; and separate material and energetical mappings are considered as the new representation of components. These developments generate aMα category, and it is shown thatMα is isomorphic to theM category of previous developments.
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  • 53
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    Bulletin of mathematical biology 37 (1975), S. 555-564 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract This paper discusses the solution of a generaln-compartment system with time dependent transition probabilities utilizing the technique described by Cardenas and Matis (1975) (hereafter abbreviated (CM)). In addition, the cumulant generating function is derived for a special class of reversiblen-compartment systems where the time-dependent intensity coefficients corresponding to the migration and death rates are some multiple of each other. The immigration rates can be any integrable function of time. The moments are also obtained and the solution to the two-compartment system is presented explicitly. The solution is illustrated with a linear and a periodic function which forms have been widely reported in the literature.
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  • 54
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    Bulletin of mathematical biology 37 (1975), S. 573-588 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The relations (inflow) = (dose)/(area under indicator curve), and (volume of distribution) = (throughflow) × (mean transit time) are derived by a matrix method for a system of interconnected subsystems, within which spatial indicator activity gradients may exist, and for compartments, within which the indicator activity is spatially uniform. The inflow theorem, is different from the outflow theorem. Equivalent labeling of multi-input systems reduces them formally to single input systems. Foreign indicator flow-volume kinetics are more general than, and include as a special case, tracer flux-mass (metabolic) kinetics. Volume of distribution in the indicator steady state may be different from the equilibrium volume of distribution.
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  • 55
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    Bulletin of mathematical biology 37 (1975), S. 219-219 
    ISSN: 1522-9602
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  • 56
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    Bulletin of mathematical biology 37 (1975), S. 291-299 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Perturbation methods are applied to a differential equation predator-prey model to find the approximate amplitudes and period of limit cycle solutions. In the model the feeding rate per unit predator per unit prey decreases as the prey become scare. The rigorous applicability of the perturbation technique depends on the assumptions that the limit cycle amplitude is relatively small and that near the equilibrium point the growth rate of each species is most sensitive to changes in the density of the other species. The second assumption is usually roughly satisfied in practice and examples are considered which suggest that the first assumption can be greatly relaxed.
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  • 57
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    Bulletin of mathematical biology 37 (1975), S. 367-387 
    ISSN: 1522-9602
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    Topics: Biology , Mathematics
    Notes: Abstract Signal Detection Theory can be used to provide a mathematical model describing the choice of a predator trying to distinguish between a model and a Batesian mimic. The mathematical model yields a number of a deductions, in particular that it may or may not assist the mimic population if mimics more closely resemble their models. The assumptions underlying the analysis are discussed in some detail.
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    Bulletin of mathematical biology 37 (1975), S. 419-425 
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    Notes: Abstract A new type of physical transition, denotedS→S *, has been detected in irradiated organic molecules (λ=546 nm) through their interaction with specific biological macromolecules. In a specific enzyme-substrate interaction, a clear enhancement of the reaction rate is observed, when the substrate is irradiated with sharply well defined times. These “efficient irradiation times” are always of the 5k sec type (k=1, 2, 3, …). They have been consistently revealed in a great number of specific biological interactions. The present note demonstrates an important property, i.e. that forevery irradiation time aS→S * transition is induced in organic molecules. It is shown that for any irradiation times different from the 5k sec type (k=1, 2, 3, …) states of theS * type may occur, but the biological macromolecules may “detect” only theS * states induced by irradiations of the 5k sec type.
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    Bulletin of mathematical biology 37 (1975), S. 459-470 
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    Notes: Abstract A semi-empirical model applicable to the flow of blood and other particulate suspensions through narrow tubes has been developed. It envisages a central core of blood surrounded by a wall layer of reduced hematocrit. With the help of this model the wall layer thickness and extent of plug flow may be calculated using pressure drop, flow rate and hematocrit reduction data. It has been found from the available data in the literature that for a given sample of blood the extent of plug flow increases with decreasing tube diameter. Also for a flow through a given tube it increases with hematocrit. The wall layer thickness is found to decrease with increase in blood hematocrit. A comparison between the results of rigid particulate suspensions and blood reveals that the thicker wall layer and smaller plug flow radius in the case of blood may be attributed to the deformability of the erythrocytes.
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    Bulletin of mathematical biology 37 (1975), S. 489-504 
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    Notes: Abstract Three dimensional laminar, viscid flow is developed for Newtonian fluids which provides absolute values for axial, radial and tangential velocity fields everywhere if the dimensions of the vessel are known and two simultaneous axial velocities e.g. on and off the central axis in the same plane, and the central axis axial velocity gradient are measured. In addition, normal and shear stresses are determinable. The equation set satisfies geometric and other known flow limiting conditions such as no slip at surfaces etc. and are amenable for inclusion in general, dynamic flow expressions. Alternatively they may be used alone for certain problems involving gradients and secondary flows. A range of illustrations are shown for a distorting vessel with elliptic cross-section and small axial taper (analogous to the pulmonary trunk during ejection).
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    Bulletin of mathematical biology 37 (1975), S. 521-553 
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    Notes: Abstract A regulated left ventricular dynamics model is presented which involves interaction of the dynamics of the left ventricular and circulatory systems and their regulation by the central nervous system. On-line human parametric simulation (parameter estimation) and consequential prognostic implications (based on parametric values) are demonstrated. Model responses to simulated physiologic stresses help delineate tolerances of subjects. In order to have an estimate of the reliability of the model, the sensitivity of the model's responses to changes in the values of its intrinsic parameters is assessed. Also determined is the extent to which errors in measuring the pressure affect the calculated values of the model's simulation parameters and subsequently influence the values of other diagnostically useful variables (such as contractility, oxygen consumption rate, heart rate), when the model is used to determine the limiting physiological stress sustainable by the subject. A comparison of the model's composition with those of other similar cardio-circulatory models is included.
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    Bulletin of mathematical biology 37 (1975), S. 659-673 
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    Notes: Abstract Then-stage harvesting strategy of Elizarov and Svirezhev is examined. As a result, some important new features appear. A discussion is presented on whether or not one should harvest a species at one time stage or wait until a later time. The paper is concerned with contributions which are primarily mathematical formulations and results for continuous, as well as discrete time, logistic growth of a single species being harvested. Age class structure is ignored.
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    Bulletin of mathematical biology 38 (1976), S. 205-207 
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    Bulletin of mathematical biology 38 (1976), S. 161-192 
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    Notes: Abstract In order to evaluate the effect of anatomic asymmetries on the gas concentration distribution in the pulmonary airways, a Monte Carlo simulation of combined bulk flow and molecular diffusion was carried out in a realistic distal airway model (Parkeret al., 1971). This airway model, composed of branches distal to the 0.5-ram diameter airways, contained an upper symmetric segment consisting of four generations of conducting airways and a lower asymmetric segment of alveolar ducts and sacs arranged in five transport paths of varying lengths. In accounting for the volume increases of these ducts and sacs occurring during normal respiration, uniform alveolar filling rates and a fixed length-to-diameter ratio of all airways were assumed. For a pulse injection of inert tracer gas, the simulation was employed to determine the longitudinal concentration profiles in the conducting airways. In the alveolated airways, not only were the longitudinal profiles determined along each path, but radial transport from the core to the periphery of the airways was considered. The results of the simulations indicate that geometric asymmetries alone contribute substantially to regional concentration variations in the distal airways. For example, when a gas bolus is injected at mid*inspiration, there are concentration differences as great as 40% between two points along different transport paths located equi-distant from the proximal end of the model. As viewed from the terminal end of the model (acinus), average concentration differences as large as 6-to-1 exist between the longest and shortest transport paths respectively for gas boli introduced near the end of inspiration. The results further indicate because of large radial diffusion rates, no significant concentration differences exist between the periphery a-ld the central core of alveolated airways. Simulation of the expired concentration profiles indicate that boll injected very late during inspiration exhibit a sloping tail, unlike the earlier injected boll whose tails are virtually horizontal. Through the use of superposition teehniqnes, it was found that these sloping tails correspond to an alveolar slope of 1.5 vol% between 750 and 1250 ml expired for a continuous washing of tracer. This result is in disagreement with other transport analyses which did not directly account for the effect of geometric asymmetries.
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    Notes: Abstract Assuming a spherical geometry for the left ventricle, passive elastic stiffness-stress relations have been obtained on the basis of linear elasticity theory and large deformation theory. Employing pressure-volume aata taken from rat hearts of various age groups, it is shown that young rat heart muscle (1 month) is stiffer than either adult (7 months) or old rat heart muscle (17 months). Although the qualitative results are similar for both elasticity theories, the large deformation theory gave results in closer agreement with those obtained from papillary muscle studies. These results imply that stiffness of muscleper se can be assessed from left ventricular pressure-volume data.
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    Bulletin of mathematical biology 38 (1976), S. 277-293 
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    Notes: Abstract Deliberate evaluation of the quantum theory of nerve excitation is made by comparing it with Hill's theory in fitting the experimental data on threshold-frequency relation, optimum frequency (v0) for nerve excitation and strength-duration relation. Decrease of v0 and increase of all the time constants (Hill's λ andk, Wei'sT 2 and spike durationw) with decreasing temperature are interpreted on the basis of the dipole relaxation timeT 2 but inexplicable from Hill's theory or any other existing theory. The closeness ofk,T 2 andw values is explained. A variety of experimental results obtained by others is discussed. Finally, a comparison is made between the Hodgkin-Huxley equations and the quantum theory. Most of the facts (electrical and non-electrical) tend to support the thesis that nerve excitation is a macroscopic expression of quantum transitions of dipoles between energy states.
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    Bulletin of mathematical biology 38 (1976), S. 317-319 
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    Notes: Abstract In the periodic Leslie model the asymptotic period of total population is a divisor of the asymptotic period of the population vector. Under reasonable circumstances these periods are identical.
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    Bulletin of mathematical biology 38 (1976), S. 305-315 
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    Notes: Abstract A number of biological branching systems, such as the bronchial and pulmonary arterial trees, are being investigated in an ongoing study in order to define their physiological properties. The technique involves the description of branching trees by the use of hierarchical systems of ordering, especially those described by Horsfield and by Strahler. During this work some mathematical properties of branching trees were demonstrated and these are described in this paper.
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    Bulletin of mathematical biology 38 (1976), S. 323-324 
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    Bulletin of mathematical biology 38 (1976), S. 209-217 
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    Bulletin of mathematical biology 38 (1976), S. 387-400 
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    Notes: Abstract Luteinizing hormone (LH) is secreted continuously from the anterior pituitary gland. The concentration in the blood of this gonadotropic hormone plays a regulatory role in the development of puberty in both sexes, in the induction of ovulation in females, and in the production of testosterone in males. The secretion of LH is in turn controlled by luteinizing hormone releasing hormone (LHRH) secreted by the hypothalamus. LH and LHRH are removed from the blood by degradation and excretion. This hormonal system is modelled by a system of ordinary differential equations based upon specific physiological and biochemical assumptions current among experimentalists in this field. The one exception is the assumption that LHRH may bind reversibly to a serum protein; an analysis of the data shows that this or a similar mechanism is a crucial specification. Data on the serum levels of LH and LHRH in two human subjects were fitted using the model. The data consist of the transients and subsequent decays created by a bolus intravenous injection of LHRH.
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    Bulletin of mathematical biology 38 (1976), S. 401-413 
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    Notes: Abstract A thick-wall incompressible, elastic sphere was used as a model for the diastolic rat left ventricle. A model for myocardial nonhomogeneity was derived assuming that fiber (circumferential) stress was independent of position in the ventricular wall. The theoretical implications of the resulting constitutive relations together with the spherical model were analyzed in the context of large deformation elasticity theory. It was found that muscle stiffness at a given level of uniaxial stress increased monotonically from the endocardium to the epicardium. In addition, fiber stress was found to be essentially a linear function of transmural pressure above a pressure of 6 g/cm2. It was also shown theoretically that neglecting the nonhomogeneity of the myocardium resulted in a state of stress which differed significantly from that predicted by the nonhomogeneous model. For example, at a transmural pressure of 14 g/cm2, fiber stress in the nonhomogenous model was equal to 17 g/cm2 while fiber stress in the homogeneous model varied between 100 g/cm2 at the endocardial surface and 2 g/cm2 at the epicardial surface. The change in muscle stiffness with position which characterized the nonhomogeneous model also tended to linearize the highly curvilinear radial stress distribution predicted by the homogeneous model at a given transmural pressure.
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    Bulletin of mathematical biology 38 (1976), S. 435-444 
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    Notes: Abstract The phenomenon of axonal transport has been well documented (Ochs, 971; Lasek, 1970; and Grafstein, 1967). In a previous paper, we showed how diffusion alone could not account for this process. In this report we show that convection or convection with diffusion can account for the observed build-up of material. By including a first-order catabolic sequestration term, we are able to offer an understanding of the several apparent rates of transport with the same underlying velocity and variable sequestration.
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    Bulletin of mathematical biology 38 (1976), S. 459-465 
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    Notes: Abstract It is known that the Lotka-Volterra coupled nonlinear differential equations for a two-species prey-predator ecosystem possess a periodic solution, although its exact form is not yet obtained analytically. The conventional linearization approximation for solving these nonlinear equations leads to a harmonic oscillator whose frequency depends only on the intraspecific coefficients. We propose here a prescription for obtaining nonlinear correction to the linear frequency by using the Hamilton-Jacobi canonical formalism of classical mechanics. It is found that the first-order correction, which also involves interspecific parameters, exhibits the basic qualitative features of the nonlinearity.
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    Bulletin of mathematical biology 38 (1976), S. 467-478 
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    Notes: Abstract Environmental safety testing typically requires procedures for extrapolating from the relatively high experimental to the very low use doses of potentially harmful substances. In the present paper, a stochastic mammillary compartmental model for environmental safety testing is proposed and extrapolation procedures based on its dose-response relationship are developed. The proposed model is a direct generalization of one of the basic safety models, the one-hit model, in that a harmful reaction is assumed to occur if at any time any of the peripheral compartments attains a specified threshold of particles. Consideration of a closed model yields an upper bound on the probability of attaining a certain threshold level, thus providing a conservative procedure for extrapolating to a low dose, while a lower bound obtained from a related open model provides a useful monitoring device as to the sharpness of the upper, bound. The extrapolation procedure is illustrated with simulated data and approximations for initial values are developed.
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    Bulletin of mathematical biology 38 (1976), S. 505-516 
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    Notes: Abstract By using chromosome images as a framework, algorithms for finding most dissimilar images are presented and illustrated by examples. In terms of angles, a chromosome image consists of two exterior biangles and two interior biangles. Biangles are defined and classified into 180° biangles, 〉180° biangles and 〈180° biangles. The dissimilarity of biangles and its geometric interpretation together with various properties of biangles are also presented. The results may have useful applications in pattern recognition, scene analysis, information storage and retrieval, artificial intelligence and fuzzy set theory.
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    Bulletin of mathematical biology 38 (1976), S. 517-526 
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    Notes: Abstract The Volterra equations which represent competitions between two species are utilized to examine the phenomenon of boundary formation between two species of plants. The set of stable stationary points for these equations is determined and is illustrated in a product space of parameters and dynamical variables. The stages of boundary appearance and succession are visualized by considering slow changes of the parameters as functions of time and space.
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    Bulletin of mathematical biology 40 (1978), S. 45-58 
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    Notes: Abstract For certain environments, the Darwinian model allows unique prediction of a function that any surviving system adapted to such an environment has to perform. This is the case for those environments that determine a “survival functional” of position in space-time of known shape. Purely temporal survival functionals can be distinguished from spatial and mixed ones. In each case, there exists an optimum path in combined physical and (reduced) metabolic space. Dependent on the admissible error, approximate solutions of different complexity are sufficient. All solutions possess an afferent, a central, and an efferent part. Within this general frame, specific, “probably simplest”, solutions are proposed for adaptive chemotaxis, insect locomotion, lower vertebrates locomotion, higher vertebrates locomotion, chronobiological systems, and immune systems, respectively—or rather, for the underlying functionals.
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    Bulletin of mathematical biology 40 (1978), S. 59-77 
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    Notes: Abstract Mathematical models afford a procedure of unifying concepts and hypotheses by expressing quantitative relationships between observables. The model presented indicates the roles of both insulin and glucagon as regulators of blood glucose, albeit in different ranges of the blood glucose concentrations. Insulin secretion is induced during hyperglycemia, while glucagon secretion results during hypoglycemia. These are demonstrated by simulations of a mathematical model conformed to data from the oral glucose tolerance test and the insulin infusion test in normal control subjects and stable and unstable diabetic patients. The model studies suggest the parameters could prove of value in quantifying the diabetic condition by indicating the degree of instability.
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    Bulletin of mathematical biology 40 (1978), S. 123-131 
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    Notes: Abstract A model for the dynamics of a single-species population whose birth rate depends on densities of previous generations is introduced. A difference equation formulation is proposed and the solutions classified for the various parameter values. Data from an experimental population of mice growing in limited space is cited and compared with the model predictions.
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    Bulletin of mathematical biology 40 (1978), S. 161-182 
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    Notes: Abstract All soft tissues are modeled as either one-dimensionalstrings, two-dimensionalmembranes, or three-dimensionalsolids. Attention is restricted to tissues in which one of the principal stress components is large and positive in comparison with the other negligible components. Results indicate the following: (1) If a deformed string isconstrained to lie on a surface and is free of tangential pressure, the tension is carried by rays which are geodesics of the surface. If a string or membrane isfree to deform in space without normal pressure, the tension rays are straight lines. If a membrane deforms without tangential surface loads, the tension rays are always geodesics on the deformed surface. If a solid deforms without body forces, the tension rays are straight lines. (2) The stress in a string is a constant if the string is free of tangential pressure and has constant cross-sectional area. The stress in flat tension fields free of tangential surface loads decays inversely with distance along a tension ray from the edge of regression. The stress in a spherically symmetric tension field free of body forces decays inversely with the square of the distance from the center of the sphere. (3) Stress singularities can occur in soft tissues, such as at the corners of a closed rectangular hole in a flat membrane strip. (4) The tension rays in the torsion of soft annular membranes are more steeply inclined from the radial direction than the tension rays for hard metals equally displaced.
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    The Geneva risk and insurance review 10 (1978), S. 50-66 
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    Topics: Economics
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    The Geneva risk and insurance review 10 (1978), S. 44-49 
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    Notes: Conclusion For all these reasons, the rediscovery of the equivalence theorem, first stated by David Ricardo in 1817, must be rejected as an adequate basis for policy, just as Ricardo had denied its applicability to the real world. Correspondingly, the concern with the adverse consequences of unfunded social insurance wealth for the supply of national saving, capital intensity, and living standards remains well founded. p ]If, as a practical matter, public pension and social security programs will never be funded actuarially in the United States and most other postindustrial countries, then government-supervised substitution of private for public retirement plans is the only way to achieve at least partial funding. If such substitution follows the British model of allowing employers to contract out of the earnings-related part of the state scheme if equivalent pensions are provided by the company plan, payroll taxes and social security wealth decline so as to reduce their adverse impact on capital formation.
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    The Geneva risk and insurance review 10 (1978), S. 73-84 
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    The Geneva risk and insurance review 10 (1978), S. 85-95 
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    The Geneva risk and insurance review 10 (1978), S. 96-98 
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    The Geneva risk and insurance review 11 (1979), S. 5-13 
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    The Geneva risk and insurance review 10 (1978), S. 67-72 
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    Notes: Summary: Social Policy in the Italian Economy Favourable social and economic conditions constitute the essential framework for a stable development of savings. Saving in the form of insurance becomes advantageous for the individual, and private insurance can thus extend its activity, when social attitudes and the economic situation favour the propensity to save. If conditions change, the State can take over the coverage of risks through social insurance. By means of this institutions, an anti-cyclical policy can be pursued: the amount of social security contributions, for instance, can be increased during the expansion of the cycle and the amounts thus accumulated can be used to grant benefits during the recession period, when contributions can be fixed at a lower percentage of wages. Another type of policy can be pursued by government authorities: that of adjusting social security contributions to industrial profits, thereby directing the subsequent effects on economic growth. Inflation cab cause instability in decisional policies taken by private insurance companies. A solution to the unbalanced increase of costs can be found in index-linking. Life policies of this kind, for instance, cab be closely related to investments in houses, to be bought by the insured themselves in price-linked instalments. After a reference to present developments regarding risk instability and to possibilities of new forms of insurance, this paper considers the competition resulting from the opening of the EEC insurance markets as an opportunity for the Italian market to strengthen its structures.
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    Bulletin of mathematical biology 39 (1977), S. 663-678 
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    Notes: Abstract A number of apparently different lines of inquiry into fundamental biological processes point to the central role played by the notion of observation in the theory of biological systems. Not only do we use the results of our own observations to obtain the system descriptions which are the starting-points for an understanding of biological processes, but it is a basic postulate of physics that the interactions between biological systems themselves can be regarded as observations. On this basis, it is clear that we cannot properly understand biological interactions unless the observables we employ for system description are the same as those involved in the interactions we are describing. To do this requires a general theory of observables and system description, establishing the relationship between different modes of description. A sketch of such a theory is developed in the present paper, using only two postulates: (a) that all interactions are determined by the values of observables of a system evaluated on specific states, and (b) that real-valued observables suffice. As an application, a specific test is proposed whereby it can be determined whether the observables employed to describe interacting systems are sufficient to specify the observables involved in the interaction itself.
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    Bulletin of mathematical biology 39 (1977), S. 679-691 
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    Notes: Abstract Differential equations are derived whose solution gives the cross-sectional shape of a flexible tube as a function of the transmural pressure. These equations are solved digitally to produce a series of closed curves, each curve representing the shape of a cross section for a particular set of conditions. These are then applied to the case of systemic arteries, pulmonary arteries, and large veins. The results predict that systemic arteries must always be circular, even when the internal and external pressures are equal. In veins, a small positive internal pressure causes them to become circular, regardless of their initial state, with negligible stretching. Further increases in internal pressure cause the area of the cross section to increase due only to stretching, the shape remaining essentially circular. With pulmonary arteries, known to be noncircular, changes in the cross-sectional area result from a combination of stretching and changes of shape.
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    Bulletin of mathematical biology 39 (1977), S. 693-704 
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    Notes: Abstract Stochastic models of human reproduction are beginning to play significant roles in the evaluation of family planning programs. A class of stochastic processes called absorbing, agedependent, semi-Markov processes frequently arises in the construction of such models. The paper begins with a discussion of some technicalities regarding absorbing, age-dependent, semi-Markov processes. Then, an algorithm due to Littman, which makes possible the computerization of this class of stochastic processes, is presented. Briefly, Littman’s algorithm provides an efficient method for numerically solving systems of renewal type integral equations, provided the system does not contain a large number of equations. After setting down a concrete model for a large clinical trial of intrauterine devices conducted in Taiwan, the paper concludes with a discussion of a method for validating the model based on the data collected in the clinical trial.
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    Bulletin of mathematical biology 39 (1977), S. 743-743 
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    Bulletin of mathematical biology 39 (1977), S. 705-719 
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    Notes: Abstract Some theoretical requirements for the valid use of hemolytic plaque inhibition as a method for studying cellular selection and recognition in an immune response are reviewed. Aside from providing a rational basis for the use of this technique, the theory resolves a growing body of apparently conflicting results on the affinity regulation of IgM secreting cells and can also be used to deduce structural (in particular, morphological) features of the IgM molecule. The diverse predictions of the theory are examined in light of experimental results and find support in a wide data base. Additional specific experiments are proposed which can be used in conjunction with the theory to help clarify the relation between cellular proliferation and maturation.
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    Bulletin of mathematical biology 39 (1977), S. 721-741 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A theory of the cell volume is presented with emphasis on the swelling effect of high concentrations of KCl and other chloride salts. In this theory a particular cell volume represents a state of balance between the tendency of the cell water to build deeper layers of polarized water and the restraining forces exerted by the salt linkages and H-bonds. Taking into account also the different structure-breaking effects of different salts, theoretical curves can be constructed which describe the complex multiple peak-plateau of swelling curve observed in frog muscle in response to increasing concentrations of different chloride salts.
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  • 95
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    Bulletin of mathematical biology 40 (1978), S. 211-221 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Non-steady-state equations for kidney models are stated. General conservation relations for these equations are derived. Transient equations for the central core model of the renal medulla are developed. Solution of the equations by Laplace transform methods for time invariant volume flows is discussed. The general theory of solving models with time dependent flows by finite difference methods is developed.
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  • 96
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    Bulletin of mathematical biology 40 (1978), S. 513-524 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The behavior of large systems of randomly-interacting variables is examined using an intentionally simplified model. The stable positive solutions are found to exhibit to a significant degree some well-known properties of ecological systems. This resemblance (including for example the predominance of “predator-prey” interactions) is all the more striking in view of the lack of biological “data” at the input end. The findings suggest it advisable to distinguish two kinds of properties in ecosystems. One kind would depend on specifically biological mechanisms; the other would characterize a wide class of persistent systems, and arise from the need for a dynamic balance between positive and negative feedback.
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  • 97
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    Bulletin of mathematical biology 40 (1978), S. 499-512 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract For the tumor model of Skipper and Zubrod, which has been analyzed previously for the theoretical FLM function and the effect of chemotherapy against tumors of known or assumed kinetic characteristics, the theoretical continuous labeling (CL) function is derived by considering an equivalent tumor (in terms of unlabeled cell populations) in which the density function of phase duration of cells inS-phasef 2(a 2)=δ(a 2−∞) and the loss functionL 2(t)=0. This mathematical concept of blocking is applied to the analysis of synchronization in tumor growth and blocking effects in cancer chemotherapy. These effects of chemical agents on the cell cycle progression are being incorporated into a previously written computer simulation program for cancer chemotherapy. Whereas, a program is written and used to simulate the CL functions for L1210 leukemia, and primary and metastatic Lewis lung carcinoma.
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  • 98
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    Bulletin of mathematical biology 40 (1978), S. 525-533 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Global stability is established in a class of prey-predator models. This includes a prey-predator model in which the predator has Type 2 functional response and no intraspecific interactions. Two simple examples demonstrate that Kolmogoroff’s theorem does not apply to some members of this class of models.
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  • 99
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    Bulletin of mathematical biology 40 (1978), S. 535-540 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The skeletal muscle is regarded as a periodically deformed plate. An equation of energy for the biological tissue in the system is used in the Lagrange variables. With the heat exchange through the above tissues to the exterior media and also with account of some relations between the physiological factors the approximate analytical solution for this equation is obtained and compared with the physiological data.
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  • 100
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    Bulletin of mathematical biology 40 (1978), S. 541-545 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract One of Bobisud's (1976) models for the evolution, of cannibalism is discussed. His analysis is criticised for not being based on the principle of individual selection. Assuming the operation of that principle, we show by simulating his model that cannibals may establish themselves in a noncannibal population. This will happen both in cases where Bobisud concluded cannibalism to be optimal and in cases where he concluded cannibalism not to be optimal.
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