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  • Rats  (224)
  • Haplorhini  (40)
  • American Association for the Advancement of Science (AAAS)  (262)
  • American Institute of Physics (AIP)
  • Elsevier
  • Periodicals Archive Online (PAO)
  • 1975-1979  (262)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (262)
  • American Institute of Physics (AIP)
  • Elsevier
  • Periodicals Archive Online (PAO)
  • Springer  (8)
Years
Year
  • 1
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    Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-24
    Description: Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chopra, I J -- New York, N.Y. -- Science. 1978 Feb 24;199(4331):904-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dithiothreitol/pharmacology ; Female ; Fetus/*metabolism ; Liver/embryology/*metabolism ; Pregnancy ; Rats ; Sheep ; Sulfhydryl Compounds/*metabolism ; Sulfhydryl Reagents/pharmacology ; Thyroxine/*metabolism ; Triiodothyronine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montigny, C -- Aghajanian, G K -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725608" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Decerebrate State ; Drug Synergism ; Geniculate Bodies/*drug effects ; Hippocampus/*drug effects ; Male ; Neural Inhibition/drug effects ; Norepinephrine/pharmacology ; Pyramidal Tracts/drug effects ; Rats ; Receptors, Serotonin/*drug effects ; Serotonin/*pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The stomach signals satiety (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Inflatable pyloric cuffs and stomach tubes were implanted in rats. With the cuff inflated and a valve to limit intragastric pressure to that accompanying normal satiety, they drank only as much when they had been deprived of food for 12 hours as without inflation of the cuff. However, they overdrank with the cuff inflated when they had been water deprived for 12 hours. When 10 ml of milk was withdrawn from the stomach with the cuff inflated, compensatory drinking occurred. Further, compensatory drinking also occurred when milk escaped from the stomach into the duodenum. Satiety signals thus arise from the stomach.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deutsch, J A -- Young, W G -- Kalogeris, T J -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):165-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drinking Behavior/physiology ; Duodenum/physiology ; Food Deprivation ; Male ; Rats ; Satiation/*physiology ; Satiety Response/*physiology ; Stomach/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Functional plasticity in the immature striate cortex of the monkey shown by the [14C]deoxyglucose method (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of the ocular dominance columns in the striate cortex of the monkey in the first day of life. In contrast to the stability of these columns in more mature brain, monocular deprivation for 3 months from the first day of life results in their complete disappearance and a reversion of the autoradiographic pattern to that seen in animals with normal binocular vision. These results are consistent with a reorganization of the representation of the visual fields of the two eyes in the striate cortex and provide additional evidence of the plasticity of the striate cortex of the monkey in early life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Des Rosiers, M H -- Sakurada, O -- Jehle, J -- Shinohara, M -- Kennedy, C -- Sokoloff, L -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):447-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/physiology ; Brain Mapping ; Cell Differentiation ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Female ; Haplorhini ; Male ; Vision, Ocular ; Visual Cortex/*cytology/physiology ; Visual Pathways/*cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Nucleosome arcs and helices (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Crystals and other regular arrangements of nucleosome cores have been obtained and analyzed in the electron microscope. Two types of regular structures have been studied in detail, the nucleosome arcs and cylinders. The latter are composed of concentric cylindrical layers of intertwined right-handed helices of nucleosome cores. These studies lead to the following conclusions and concepts. The overall structure of the nucleosome core is a short, wedge-shaped cylinder measuring about 110 by 110 by 60 angstroms. Nucleosome cores interact primarily between top and bottom planes. Nucleosome cores exhibit large conformational variability. A pivot allowing two degrees of rotational freedom is postulated in the region of the 70th base pair to account for this property of the nucleosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dubochet, J -- Noll, M -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):280-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatin/*ultrastructure ; Crystallography ; Macromolecular Substances ; Micrococcal Nuclease/metabolism ; Microscopy, Electron/methods ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Thermoregulation is impaired in an environment without circadian time cues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Squirrel monkeys synchronized to a 24-hour light-dark cycle show a prominent circadian rhythm in body temperature which is regulated against mild environmental cold exposures throughout the 24-hour day. However, cold exposures produce significant decreases in core body temperature when the circadian rhythms of the animal are free-running in the absence of environmental time cues. Effective thermoregulation appears to require the precise internal synchronization of the circadian timekeeping system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuller, C A -- Sulzman, F M -- Moore-Ede, M C -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):794-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414356" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Temperature Regulation ; *Circadian Rhythm ; Cold Temperature ; Cues ; *Environment ; Environmental Exposure ; Haplorhini ; Homeostasis ; Male ; Saimiri ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, P S -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):768-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Brain/embryology/growth & development ; Brain Mapping ; Cell Differentiation ; Cerebral Cortex/*cytology ; Haplorhini ; Macaca mulatta ; Neural Pathways/*cytology ; Synapses/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    beta-Adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The density but not the affinity of beta-adrenergic receptors declined significantly with age in rat pineal gland, corpus striatum, and cerebellum, as determined by the binding of tritiated dihydroalprenolol. Exposing rats to light for 12 hours increased the binding of this radioligand in 3-month-old but not in 24-month-old rats. The reduced responsiveness to catecholamines seen in aging may be due to a decrease in the number of beta-adrenergic receptors which, in turn, may be caused by an impaired capacity of receptors in aged animals to adapt to changes in adrenergic neuronal input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenberg, L H -- Weiss, B -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208145" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Alprenolol/analogs & derivatives/metabolism ; Animals ; Brain/*metabolism ; Cerebellum/metabolism ; Circadian Rhythm ; Corpus Striatum/metabolism ; Kinetics ; Light ; Male ; Neuroglia/metabolism ; Pineal Gland/*metabolism ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Subsynaptic plate perforations: changes with age and experience in the rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: The relative frequency of appearance of discontinuities in the postsynaptic thickening, or perforations in the subsynaptic plate, increased with age and experience. Rats reared from weaning in complex or social environments had a significantly higher proportion of occipital cortical synapses with perforations than did rats reared in isolation. In addition, the relative frequency of these perforations more than tripled between 10 and 60 days of age. Shifts in the frequency of perforations can occur independently of changes in the size of synpases. This result suggests a new potential mechanism of synaptic plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenough, W T -- West, R W -- DeVoogd, T J -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1096-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715459" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cerebral Cortex/ultrastructure ; Environment ; Male ; Occipital Lobe/*ultrastructure ; Rats ; Synapses/ultrastructure ; Synaptic Membranes/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Early maternal separation increases gastric ulcer risk in rats by producing a latent thermoregulatory disturbance (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: Rat pups that are separated early from their mothers, at postnatal day 15, become hypothermic when subjected to physical restraint on postnatal day 30. Restraint of separated pups also elicits an unusually high incidence of gastric erosions, as well as insomnia and an increase in quiet wakefulness. If hypothermia during restraint is prevented, neither the erosions nor the behavioral responses occur. Rat pups separated at the customary age (postnatal day 22) do not become hypothermic during restraint, and the restraint of such pups is not associated with either gastric erosion or insomnia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ackerman, S H -- Hofer, M A -- Weiner, H -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):373-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566471" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/physiology ; Arousal/physiology ; Behavior, Animal/physiology ; *Body Temperature Regulation ; Food Deprivation ; Humans ; *Maternal Deprivation ; Rats ; Restraint, Physical ; Sleep/physiology ; Stomach Ulcer/*etiology ; *Stress, Psychological/physiology ; Wakefulness/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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