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  • Biochemistry and Biotechnology  (2.788)
  • Engineering General  (2.473)
  • Biochemistry  (522)
  • Wiley-Blackwell  (5.780)
  • Springer  (3)
  • Nature Publishing Group
  • 1985-1989  (5.783)
Sammlung
Verlag/Herausgeber
  • Wiley-Blackwell  (5.780)
  • Springer  (3)
  • Nature Publishing Group
Erscheinungszeitraum
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Pharmacy world & science 11 (1989), S. 146-150 
    ISSN: 1573-739X
    Schlagwort(e): Agonists ; Antagonists ; Biochemistry ; Central nervous system ; Ligands ; Pharmacology ; Receptors, histamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions, as well as on specific ligands, both agonists and antagonists. It is concluded that several aspects of the pharmacology of histamine in the central nervous system are still a matter of empirism and speculations. The recent publications on the brain-penetrating H2 antagonist zolantidine and the selective H3 agonists and antagonists are expected to contribute to the knowledge of the histaminergic pathways in the brain. Therapeutical areas within the central nervous system are related to behaviour (including wake-sleep), neuroendocrinal processes, the control of muscle activity and cerebral circulation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Pharmacy world & science 11 (1989), S. 3-8 
    ISSN: 1573-739X
    Schlagwort(e): Biochemistry ; Clofazimine ; Dapsone ; Ethionamide ; Isoniazide ; Mechanism of action ; Mycobacterium leprae ; Prothionamide ; Quinolones ; Ribonucleotide reductase inhibitors ; Rifampicin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract From a pharmacochemical point of view the existing anti-leprotics as well as possible innovations in the chemotherapy of leprosy are discussed. Of the main anti-leprotics, which are used nowadays — dapsone, rifampicin, clofazimine, isoniazide, ethionamide and prothionamide — the mechanism of action, the main problems in their application and possibilities to develop improved variants are reviewed. Based on the chemistry ofMycobacterium leprae, the target systems for new anti-leprotics are identified. These systems include the cell wall, the catabolism of reactive oxygen species, the metabolisms of carbon sources, the amino acid metabolism and the uptake of iron. Two possible new lead structures from other fields, 4-quinolones and mycobacterial ribonucleotide reductase inhibitors are presented.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Pharmacy world & science 8 (1986), S. 209-222 
    ISSN: 1573-739X
    Schlagwort(e): Biochemistry ; Pharmacology ; Receptors, adrenergic, beta ; Review
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 285-299 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper presents a finite element analysis of laminated bimodulus composite thin shells of revolution using a 48 d.o.f. doubly curved quadrilateral finite element. All the three displacements of the shell element reference surface are expressed as products of one-dimensional first-order Hermite interpolation polynomials. The constitutive relationship for a bimodulus composite is assumed to depend on the fibre-direction strain experienced by each orthotropic layer. Consequently the true state of strain and the corresponding constitutive relationship in a bimodulus composite structure are to be determined iteratively. The true state of stress/strain is obtained by specifying a maximum error in the locations of the two neutral surfaces (one along each of the orthogonal reference axes) in the shell. The use of the quadrilateral shell finite element is validated by solving the problem of (i) a freely supported single layer (0°) bimodulus composite square plate and (ii) a freely supported single layer (0°) cylindrical panel, which are subjected to sinusoidal transverse loading and for which analytical solutions are available. Next, the problems of a single layer (90°) pinched cylindrical shell and a single layer (0°) open crown hemispherical shell are solved to show the ability of the present program.
    Zusätzliches Material: 14 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 329-347 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Recently developed solid modelling systems for the design of complex physical solids using interactive computer graphics offer the exciting possibility of an integrated design/analysis system. Called geometric modellers, these systems build complex solids from primitive solids (cubes, cylinders, spheres, solid patches, etc.) and macro solids (combination of primitives)3, 4, 8, 16, 18, 25, 38. To provide an effective structural analysis capability for these systems, methods must be devised to ease the burden of discretizing the solid geometry into a user controlled (usually locally graded) finite element mesh. The purpose of this paper is to describe an interactive solid mesh generation system capable of generating valid meshes of well-proportional tetrahedral finite elements for the decomposition of multiply connected solid structures. The system uses a semi-automatic node insertion procedure to locate element node points within and on the surface of a structure. An independent automatic three-dimensional triangulator then accepts these nodes as input and connects them to form a valid finite element mesh oftetrahedral elements. Although this report makes use of a modeller based on a constructive solid geometry representation (a so-called CSG modeller), the mesh generation strategy elaborated herein is completely general and makes no particular use of the CSG representation.
    Zusätzliches Material: 20 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 465-479 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: A matrix derivation of the method of partial decomposition for substructure equilibrium equations is given and algorithms and subroutines necessary for implementing a multi-level substructuring scheme are presented. The algorithms are based upon partial decomposition of skyline matrices by the Cholesky method. Transformation of co-ordinates and prediction of the skyline for higher level substructures are also discussed.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 509-528 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The use of a complete and nonsingular set of Trefftz functions in the solution of quasi-harmonic equations is demonstrated and shown to be often superior to the more conventional singularity distribution in boundary-type approximation. Procedures for coupling separate domains of such solution and indeed of deriving equivalent finite elements are demonstrated.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 579-582 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 9
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 601-616 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The displacement of a slightly compressible liquid by another in a porous medium has been modelled. This problem, which involves a moving boundary, has been numerically solved for the one-dimensional case by using the Galerkin method. State and parameter estimation have been carried out using the extended Kalman filter.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 853-881 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Two methods are compared for integrating the strains that can arise in finite element solutions for Eulerian velocity fields associated with large strain material forming processes. With the Galerkin formulation, partial differential equations for the deformation gradient are solved over the entire domain based on a weighted residual; with the streamline integrated technique, the corresponding ordinary differential equations are integrated along characteristic lines. Both methods have yielded accurate integrations for the radial flow and planar rolling problems studied. A finite element technique is also presented for ensuring that the free surfaces of the fluid flow are streamlines. This technique has been used for ensuring proper boundary conditions in the rolling analysis.
    Zusätzliches Material: 16 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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