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  • Articles  (122,262)
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  • Articles  (122,262)
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  • 1
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    OR spectrum 11 (1989), S. 1-2 
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
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  • 2
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    OR spectrum 11 (1989), S. 42-42 
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  • 3
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    OR spectrum 11 (1989), S. 3-16 
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung In diesem Beitrag wird ein Überblick über heuristische, prioritätsregelgestützte Auftragsreihenfolgeplanung gegeben. Prioritätsregeln sind in den letzten 30 Jahren eingehend anhand von Simulations-Experimenten untersucht worden. Sie haben ebenso in Programmsysteme zur Produktionsplanung und-steuerung Eingang gefunden. Der Beitrag bemüht sich um eine Klassifizierung, Charakterisierung und Beurteilung von elementaren Prioritätsregeln. Abschließend werden einige prioritätsregelrelevante Modellerweiterungen angeschnitten.
    Notes: Summary In this paper, we survey the literature on heuristic priority rule-based job shop scheduling. Priority rules have been intensively investigated over the last 30 years by means of simulation experiments. They are also used in Shop Floor Control software systems. We present a classification, a characterization, and an evaluation of elementary priority rules. Some priority rule-related model extensions are discussed.
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  • 4
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    OR spectrum 11 (1989), S. 17-24 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Betrachtet wird das Problem der Fahrplangestaltung im öffentlichen (Personen-)Nahverkehr mit dem Ziel der Minimierung der Summe der Wartezeiten für Umsteiger. Es werden heuristische Lösungsverfahren (Regret-Methoden, Verbesserungsverfahren, Simulated Annealing) sowie ein Branch-and- Bound-Algorithmus beschrieben. Die Verfahren wurden u. a. anhand von Daten aus der Praxis getestet.
    Notes: Summary The problem of minimizing waiting times of passengers who want to change communication routes at transfer stations is considered. The paper contains heuristics (regret-methods, improvement algorithms, simulated annealing) as well as a branch and boundalgorithm and provides computational results, some of them gained with practical data.
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  • 5
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    OR spectrum 11 (1989), S. 48-48 
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  • 6
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    OR spectrum 11 (1989), S. 25-41 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary A model is set up to simulate commercial flights in 4-D-mode. Basic data are standard flight tracks of German domestic flights; altitudes included range up to flightlevel FL 300. For simulation runs, flight times profiles are derived both from real flights and departure times respectively fly-over times of the Berlin gates. Aircraft movements are simulated with respect to airways, departure and arrival routes, air traffic control areas, starts and landings. Conflicts arise in the case of too short distances to other aircraft. They are solved dependently on flight attitude, e.g. en route state by changing the flight level, or by holding procedures if an aircraft cannot be sequenced for final approach. The simulation is carried out for 465 domestic flights per day. Some results and an outlook on suitable applications are given.
    Notes: Zusammenfassung Grundlagen des symbolischen Modells zur Simulation der Flugbewegungen in Zeit und Raum sind Standardrouten sowie Flughöhen bis FL 300. Flugzeiten und Flugprofile werden aus realen Flugeinsätzen abgeleitet. Die Nachbildung erfolgt in Luftstraßen, An- und Abflugrouten, CTA- und FIR-Gebieten sowie für Starts und Landungen. Vor jedem LFZ wird in Flugrichtung ein Sicherheitsbereich eingerichtet, dessen Unterschreitung durch andere LFZ Konflikte verursacht. Konfliktlösungen erfolgen unterschiedlich nach Flugzuständen, z. B. durch Flugflächenwechsel (Reiseflug) oder Warterunden (Platzanflug), falls ein LFZ zum Endanflug nicht in eine Landekette eingereiht werden kann. Die Simulation erfolgt für 465 Flüge eines Tages im nationalen Verkehr. Es werden einige Ergebnisse angegeben, ferner ein Ausblick auf mögliche Anwendungen des Modells.
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  • 7
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    OR spectrum 11 (1989), S. 43-47 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Die Klasse von sogenannten lexicographisch monotonen Verhandlungslösungen für Verhandlungsprobleme mit zwei Spielem wird in mehreren Weisen charakterisiert. Diese Lösungen sind nichtsymmetrische Verallgemeinerungen der lexicographisch egalitaren Lösung. In dieser Charakterisierung wird Monotonie der Lösung erfordert nur wenn der Lösungspunkt nicht ein Endpunkt der Pareto optimalen Menge ist. Diese Kondition wird interpretiert als Natürlichkeit oder Zwangslosigkeit der Übereinstimmung zwischen den Spielern.
    Notes: Summary The family of 2-person bargaining solutions called Lexicographic monotone path solutions — which are nonsymmetric generalizations of the lexicographic egalitarian solution — is characterized in several ways. Central in these characterizations is an interiority condition first introduced in [1] in order to characterize then-person lexicographic egalitarian solution. This condition means that a monotonicity property is required to hold only if the agreement is an interior Pareto optimal point, the interpretation being that in that case the agreement is “natural” or “unforced”.
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  • 8
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    OR spectrum 11 (1989), S. 63-63 
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  • 9
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    OR spectrum 11 (1989), S. 64-64 
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  • 10
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    Description / Table of Contents: Summary The purpose of this article is twofold. In the first place it serves as an introduction the using of the simultaneous equations method as compare with step method of cost allocation in computer centre. The model is based on the principle that no expense any service department should be distributed unless all of its expenses, including services received from other service departments, are included. Using the simultaneous equations method, ratios for distributing expenses of service departments to production departments are established which take into consideration the interaction between and among the various service departments. In the second place, to illustrate the formulating a description of a problem in terms of mathematical equations and interpreting the results.
    Notes: Zusammenfassung Der Artikel verfolgt zwei Ziele. Zum einen wird der Gebrauch simultaner Gleichungsrechnungen in der innerbetrieblichen Leistungsverrechnung im Vergleich zur sukzessiven Kostenauflösung nach der Zuschlagmethode demonstriert. Es werden Leistungsaustauschvorgänge zwischen produzierenden und/oder verwaltenden Stellen aufgezeigt. Zum anderen wird die Lösung und die Interpretation der Ergebnisse gezeigt.
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  • 11
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    OR spectrum 11 (1989), S. 64-64 
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  • 12
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    OR spectrum 11 (1989), S. 65-66 
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  • 13
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    OR spectrum 11 (1989), S. 96-96 
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  • 14
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    OR spectrum 11 (1989), S. 83-88 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Eine Verallgemeinerung von Fluß-spielen, nämlich solchen mit Komitee-Kontrolle, wird in der vorliegenden Arbeit betrachtet, um eine Darstellung nicht-negativer ausgewogener Spiele zu erhalten. Die Komitee-Kontrolle wird mit Hilfe einfacher Spiele modelliert. Ebenso werden lineare Produktionsspiele mit Komitee-Kontrolle untersucht, und Ergebnisse zur Ausgewogenheit solcher Spiele werden hergeleitet.
    Notes: Summary A generalization of flow games, namely, flow games with committee control is considered, to obtain a representation of non-negative balanced games. The committee control is modeled with the aid of simple games. Linear production games with committee control are also studied and results on the balancedness of such games are obtained.
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  • 15
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    OR spectrum 11 (1989), S. 89-95 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Ein Fahrzeuggetriebe läßt sich als System modellieren, dessen Zustände (= Gänge) einen Markov-Prozeß darstellen. Jeder Gang benützt eine charakteristische Untermenge von Komponenten (= Zahnräder usw.). Die Ausfallrate jeder Komponente wächst linear mit der zurückgelegten Betriebszeit. Der erste Ausfall einer im Einsatz befindlichen Komponente führt zum Ausfall des Getriebes. Für die Überlebensfunktion werden Konvergenzresultate und Schranken angegeben. Mittelwert und Varianz der Systemlebensdauer streben mit fallenden Ausfallraten gegen die entsprechenden Werte einer Rayleighverteilung. Die bedingten Wahrscheinlichkeiten einer Komponente, einen Defekt nach Überleben der Zeitspanne τ zu verursachen, streben asymptotisch mit τ gegen die mittleren, stationären relativen Schadensakkumulationsraten. Ein Schätzverfahren für die Modellparameter bei gegebener stationärer Verteilung des Markov-Prozesses schließt die Untersuchung ab.
    Notes: Summary A vehicle transmission box is modeled as a system, whose operating states (= speeds) perform a Markov-process. Every speed uses its own subset of components (= gears etc.). The failure rate of a component increases linearly with its accumulated operating time. The first failure of a gear causes system failure. Asymptotic results and bounds are given for the system survival function. Mean value and variance of the system lifetime tend towards their counterparts in case of a Rayleigh distribution, as component failure rates converge towards 0. The conditional posterior culprit probabilities, i.e. the probabilities to cause a system failure, given survival of a time span τ, converge asymptotically towards the stationary expected relative damage accumulation rates as τ increases. Estimators for the model parameters are given for a known stationary distribution of the Markov-process.
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  • 16
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    OR spectrum 11 (1989), S. 101-110 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung In dieser Arbeit wird ein mathematisches Modell zur Optimierung der Entladestrategie für Schiffe vorgestellt, die Schuttgüter transportieren. Unter Verwendung der Ergebnisse einer vorherigen Arbeit, die sich mit Entladeoperationen einer einzelnen Luke befaßte, wird hier die Minimierung der gesamten Entladezeit angestrebt, wobei Ablaufplanungsalgorithmen benutzt werden, die auf einer simplen Prioritätsregel basieren. Zur Validierung dieses heuristischen Ansatzes wird ebenfalls ein gemischt-ganzzahliges Optimierungsmodell eingeführt, welches Untergrenzen für die Entladezeit liefert durch Lockerung einzelner Ganzzahligkeitsrestriktionen.
    Notes: Summary A mathematical model for the optimization of the unloading strategy for ships transporting bulk goods will be presented in this paper. Using the results of a previous paper concerning the unloading operation of a single hatch, the minimization of the overall unloading time is striven for by using scheduling algorithms based on a simple priority rule. For validation of this heuristic approach a mixed-integer optimization model will also be introduced, which delivers lower bounds for the unloading time by relaxing some of the integrality constraints.
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    OR spectrum 11 (1989), S. 113-113 
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  • 18
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    OR spectrum 11 (1989), S. 111-113 
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    OR spectrum 11 (1989), S. 142-142 
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    OR spectrum 11 (1989), S. 121-130 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary A system withn elements in sequence is called a consecutive-k-out-of-n:F system if it fails wheneverk consecutive elements are failed. Consecutive-k-out-of-n:F systems can be used to model belt conveyor systems, telecommunication systems, oil pipeline systems, street lightings and other more. This paper presents formulas and algorithms for the reliability of consecutive-k-out-of-n:F systems with identical and nonidentical elements.
    Notes: Zusammenfassung Ein konsekutives-k- aus-n:F System besteht aus einer Folge vonn Elementen. Das System ist genau dann ausgefallen, wennk aufeinanderfolgende Elemente ausgefallen sind. Konsekutive-k-aus-n:F Systeme können zur Modellierung von Gurtbandförderern, Telekommunikationssystemen, Ölpipelinesystemen, Straßenbeleuchtungsanlagen usw. herangezogen werden. Diese Arbeit faßt Formeln und Algorithmen für die Zuverlässigkeit von konsekutiven-k-aus-n:F Systemen mit identischen und nichtidentischen Elementen zusammen.
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  • 22
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    OR spectrum 11 (1989), S. 131-141 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Tabu Search ist eine heuristische Methode, die für globale Optimierung mit viel Erfolg in verschiedenen Umständen angewandt wurde. Die Grundideen der Methode werden erklärt und mit Beispielen illustriert. Eine Anwendung an ein Lernprozess im Gebiet der Neuronen Netzwerke wird beschrieben.
    Notes: Summary Tabu Search is a general heuristic procedure for global optimization. Based on simple ideas it has been extremely efficient in getting almost optimal solutions for many types of difficult combinatorial optimization problems. The principles of Tabu Search are discribed and illustrations are given. An example of problem type where the use of Tabu Search has drastically cut down the computational effort is presented; it consists of the learning process of an associative memory represented by a neural network.
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  • 23
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    OR spectrum 11 (1989), S. 143-149 
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Hastings [1] benutzt Reparaturgrenzen für Ersetzungsprobleme: wenn zu einem Zeitpunkt die Reparatur eines Fahrzeugs (z. B.) hinreichend teuer ist, dann ist es ökonomisch sinnvoll, das Fahrzeug durch ein neues zu ersetzen. Numerische Resultate zeigten, daß diese Reparaturgrenzen monoton fallend sind mit zunehmendem Alter. Außerdem wurde angenommen, daß die Fahrzeuge in einem gewissen Alter unabhängig von den Raparaturkosten ersetzt werden. Die vorliegende Arbeit befaßt sich mit der theoretischen Untersuchung dieser beiden Fragen.
    Notes: Summary Hastings [1] introduced the concept of repair limits for replacement problems, the basic idea being that if, at a given time, the repair of a vehicle, for example, is sufficiently expensive, then it will be economical to replace the vehicle with a new one. Numerical results also demonstrated that repair limits decreased with age. In addition, it was assumed that, at a certain age, vehicles should be replaced whatever the repair cost. This paper addresses theoretical issues surrounding these questions.
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    OR spectrum 11 (1989), S. 150-150 
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  • 25
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    OR spectrum 11 (1989), S. 169-171 
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    OR spectrum 11 (1989), S. 159-167 
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    Description / Table of Contents: Summary The COMO III program has been used by IABG since 1975 for a great number of OR studies on air defence problems. The program has proved to be very well qualified for this purpose. In particular, the user-friendly and flexible data input for simulation runs should be stressed as well as the modular structure of the program which allows an optionally refined or aggregated modelling of the systems to be studied. Besides this, COMO III provides a standardised user-oriented data output which is sufficient for most study purposes and needs no additional programming effort.
    Notes: Zusammenfassung Das Programm COMO III, das seit 1975 bei der IABG in zahlreichen OR-Untersuchungen auf den Gebieten der Luftverteidigung und Flugabwehr verwendet wird, hat sich für derartige Untersuchungen als sehr gut geeignet erwiesen. Hervorzuheben sind insbesondere die benutzerfreundliche und flexible Dateneingabe für die Simulationsläufe sowie der modulare Aufbau des Modells, der es ermöglicht, die Abbildung der zu untersuchenden Systeme beliebig zu verfeinern oder zu aggregieren. COMO III sieht außerdem standardmäßig eine benutzerorientierte Datenausgabe vor, die für die meisten Untersuchungszwecke ausreicht und keinen zusätzlichen Programmaufwand erfordert.
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    OR spectrum 11 (1989), S. 151-158 
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    Description / Table of Contents: Summary In the course of the present reduction of the extent of vertical production in the automotive and engineering industry, it can be observed that the entrepreneur working with productive facilities becomes more and more a customer. With the help of failure data evaluation, the ordering conditions of the supplier can be appraised. The information base consists of failure data supplied by the manufacturer or of own operating data generated during the production process. With regard to single components or to the equipment as a whole, the information can be pooled in a Weibull distribution. By this means, ordering conditions offered can be evaluated under consideration of the size of the order and an allowance for wear and tear of the productive facilities. Due to this, economically justifiable decisions on taking or rejecting orders become feasible.
    Notes: Zusammenfassung Ein Betreiber von Produktionsanlagen wird im Zuge der gegenwärtig auch in der Autoindustrie und im Anlagenbau zu beobachtenden Verringerung der Fertigungstiefe zunehmend zum Auftragnehmer. Er kann mit Hilfe einer Auswertung von Ausfalldaten die vom Auftraggeber gebotenen Auftragskonditionen beurteilen. Datengrundlage sind Ausfalldaten des Anlagenherstellers oder die Daten der eigenen Betriebsdatenerfassung, die komponentenbezogen oder unter Bezugnahme auf die zu betrachtende Gesamtanlage zu Weibuliverteilungen verdichtet werden. In Abhängigkeit von der Auftragsgröße können auf diese Weise unter Berücksichtigung von Verschleißzuständen der Produktionsanlage gebotene Auftragskonditionen in der Weise beurteilt werden, daß ökonomisch vertretbare Auftragsannahme- oder ablehnungsentscheidungen getroffen werden können.
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    OR spectrum 11 (1989), S. 168-168 
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    OR spectrum 11 (1989), S. 171-171 
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    OR spectrum 11 (1989), S. 172-174 
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    OR spectrum 11 (1989), S. 176-176 
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    OR spectrum 11 (1989), S. 190-190 
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    OR spectrum 11 (1989), S. 177-184 
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    Description / Table of Contents: Summary Although simulation is so wide-spread that it is difficult to find a definition in an essay where an application is described, it has not remained constant over the years. The reason for this is the fact that the limits of simulation models have shifted. This shift is due to new scientific discoveries and technical progress; examples for this are expert systems, the development of parallel processing and neural networks. This essay intends to demonstrate how such influences within the various phases of model creation can be taken into consideration and how these influences change the simulation model.
    Notes: Zusammenfassung Obwohl die Simulation so verbreitet ist, daß sie in kaum einem Aufsatz, in dem eine Anwendung beschrieben wird, noch definiert wird, ist sie dennoch nicht zeitlich konstant geblieben. Die Ursache hierfür liegt darin, daß die Grenzen von den Simulationsmodellen sich auf Grund der wissenschaftlichen Erkenntnisse und des technischen Fortschritts, wie z. B. durch die Expertensysteme, die Parallelrechnerentwicklung oder die neuronalen Netze, erheblich verändert haben. Wie solche Einflüsse in den Phasen der Modellbildung berücksichtigt werden können und wie dadurch das Simulationsmodell verändert wird, soll hergeleitet werden.
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    OR spectrum 11 (1989), S. 196-196 
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    OR spectrum 11 (1989), S. 191-195 
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    Description / Table of Contents: Summary The technique of designing and constructing simulation models is difficult and requires a lot of knowledge and experience. In general, users of simulation models don't have this expert knowledge. Up to now, it has not been possible to incorporate the expert knowledge necessary for the overall modelling within an expert system which would then in turn make the techniques accessible to the inexperienced user. In general, the close cooperation among experts in the fields of application and simulation techniques remains — for the time being — the only guarantee for successfully scrutinizing a model study. It is, however, possible to combine expert systems and simulation models when using carefully chosen, closely defined fields of application. It is here that an important area of interest and study lies. There are three conceivable alternatives: 1. To provide a simulation model with an intelligent environment which supports the user in constructing as well as evaluating the results made. 2. An expert system contains a simulation model as a possible component. If the expert system needs information that is not directly available, a simulation model is accessed which in turn sends the necessary data back to the expert system. 3. A simulation model contains an expert system as a component. In this case, the model has specific strategies at its disposal that are to be taken into consideration. If the model reaches a point where decisions have to be made, the simulation model turns to the expert system in order to receive information on relevant decisions. These relevant decisions are then used to determine the further course of the model. All three alternatives assume that the expert system as well as the simulation system have an open architecture. The open architecture is a prerequisite for the possibility of coupling the two. Up to now, this requirement has rarely been achieved.
    Notes: Zusammenfassung Der Entwurf und der Aufbau von Simulationsmodellen ist eine schwierige Technik, die sehr viel Wissen und Erfahrung voraussetzt. Die Anwender von Simulationsmodellen verfügen in der Regel über dieses Expertenwissen nicht. Bisher ist es nicht möglich, das für die Modellierung insgesamt erforderliche Expertenwissen in ein Expertensystem zu inkorporieren um es auf diese Weise dem in der Simulationstechnik unerfahrenen Anwender zugänglich zu machen. Im allgemeinen bleibt die enge Zusammenarbeit zwischen Fachleuten auf dem Anwendungsgebiet und der Simulationstechnik bis auf weiteres die einzige Garantie für eine erfolgreiche Modelluntersuchung. In ausgewählten, sehr engen abgegrenzten Anwendungsgebieten ist es jedoch möglich, Expertensysteme und Simulationsmodelle zu vereinen. Hier entwickelt sich ein bedeutendes Arbeits- und Aufgabenfeld. Es sind drei Alternativen vorstellbar: 1. Ein Simulationsmodell erhält eine intelligente Umgebung, die den Anwender beim Modellaufbau und bei der Ergebnisauswertung unterstützt. 2. Ein Expertensystem enthält als eine mögliche Komponente ein Simulationsmodell. Falls das Expertensystem Informationen benötigt, die nicht direkt verfügbar sind, wird ein Simulationsmodell angestoßen, das die erforderlichen Daten an das Expertensystem zurückliefert. 3. Ein Simulationsmodell enthält als Komponente ein Expertensystem. In diesem Fall enthält das Modell Strategien, die zu berücksichtigen sind. Falls das Modell an einen Punkt kommt, an dem Entscheidungen getroffen werden müssen, wendet sich das Simulationsmodell an das Expertensystem und läßt sich die maßgebenden, den weiteren Modellablauf bestimmenden Entscheidungen mitteilen. Alle drei Alternativen verlangen vom Expertensystem und dem Simulationssystem eine offene Architektur. Die offene Architektur ist Voraussetzung dafür, daß sich beide Systeme koppeln lassen. Diese Forderung ist bisher kaum erfüllt.
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    OR spectrum 11 (1989), S. 204-204 
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    OR spectrum 11 (1989), S. 197-203 
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    Description / Table of Contents: Summary In different areas of materials management (purchase, disposal, storage, transport, clearing of refuse) the costs can be influenced by the input of labour. The effects of this input are problems of uncertainty. In this paper some concepts of models for a stochastic simulation of the cost-effects are introduced for situations of various input of labour. The concepts of the models consider different types of organisation of the materials management. Various assumptions are made concerning the number of the uncertain input data, the differentiation of material-and refusegroups and the extent of the available labour.
    Notes: Zusammenfassung In den unterschiedlichen Bereichen der Materialwirtschaft (Einkauf, Materialdisposition, Lagerhaltung, Transport, Reststoffentsorgung) lassen sich die Kosten durch den Einsatz des Personals beeinflussen. Die Wirkungen der gestaltenden Tätigkeiten unterliegen der Unsicherheit. In diesem Beitrag werden Modellkonzeptionen für eine stochastische Simulation der Kosten beim Einsatz unterschiedlicher Personaleinsatzzeiten vorgestellt. Die Konzeptionen der Modelle berücksichtigen verschiedene Organisationsformen der Materialwirtschaft. Außerdem werden unterschiedliche Annahmen hinsichtlich der unsicheren Einflußgrößen, der Differenzierung von Material- und Reststoffgruppen sowie der Anzahl der verfügbaren Mitarbeiter getroffen.
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    Description / Table of Contents: Summary An essential problem in implementing simulation techniques is the accuracy of the model. With the help of visualization techniques, a complex simulation model from the area of chemical production can be represented.This model can be controlled and altered interactively.Simulation and visualization can be described within object-oriented systems in a very natural way.Simulation and visualization have been implemented with the help of the Smalltalk-80-system and the Hypermedia-System with the name “The Analyst” written in Smalltalk-80. This is used in the field of operations research at the Ciba-Geigy AG, Basel.
    Notes: Zusammenfassung Ein wesentliches Problem beim Einsatz von Simulationstechniken ist die Korrektheit des Modells. Mit Hilfe von Visualisierungstechniken wird ein komplexes Simulationsmodell aus dem Bereich der chemischen Produktion dargestellt. Dieses Modell kann interaktiv gesteuert und verändert werden. Simulation und Visualisierung lassen sich mit objektorientierten Systemen auf sehr natürliche Weise beschreiben.Implementiert wurde die Simulation und die Visualisierung mit Hilfe des Smalltalk-80-Systems und des in Smalltalk-80 geschriebenen Hypermedia-Systems The Analyst. Eingesetzt wird es im Bereich Operations Research bei der Ciba-Geigy AG, Basel.
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    OR spectrum 11 (1989), S. 205-216 
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    Description / Table of Contents: Summary Knowledge based systems can be helpful to give a wider group of users access to simulation. Classifications are given for systems according to their structure and their task-sharing approach. Among the latter are systems that enable automated model creation, support the interaction of user and expert system and others, that utilize simulation as a means of knowledge acquisition. Two examples are given: Simulation Craft and a system that will support rescheduling in production environments by combining expert systems, simulation and manufacturing systems.
    Notes: Zusammenfassung Wissensbasierte Systeme können helfen, die Simulation für eine breitere Anwenderschicht nutzbar zu machen. Dazu werden Klassifikationen nach der Architektur und nach der Aufgabenteilung vorgestellt. Letztere unterscheidet Programme zur automatischen Generierung von Modellen, Systeme, die den Benutzer bei der Interaktion unterstützen, und Expertensysteme, die Simulation zur Wissensakquisition nutzen. Als Beispiele werden Simulation Craft und ein System vorgestellt, das durch Koppelung von Expertensystemen, Simulation und einem PPS-System die Umdisposition in der Fertigungsplanung unterstützen soll.
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    OR spectrum 11 (1989), S. 230-230 
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    OR spectrum 11 (1989), S. 238-238 
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    Description / Table of Contents: Summary The high complexity of production planning models suggests their intractability to exact optimization. In practice, therefore, simulation is preferred. The paper reviews the state of standard software packages for mathematical programming and simulation and their characteristics. Then, modelling techniques for dynamic production systems are discussed. Both tools, a mathematical programming systems software and a simulation language, are used to solve selected problems from the area of job shop scheduling and serial production. The solutions are compared. They give the basis for a critical evaluation of the two approaches.
    Notes: Zusammenfassung Die hohe Komplexität von Modellen zur Produktions- und Ablaufplanung läßt sie einer exakten Optimierung nur schwer zugänglich erscheinen. In der Praxis wird deshalb häufig auf die Simulation ausgewichen. Der Beitrag diskutiert zunächst Entwicklungsstand und Merkmale von Standard-Softwaresystemen zur Mathematischen Optimierung und von Simulationssprachen. Nach Diskussion der Modellierungstechniken für dynamische Produktionssysteme werden anhand ausgewählter Probleme der Werkstatt- und der Fließfertigung die mit einem Planungssystem auf der Basis von MP-Software und der Simulation erhaltenen Lösungen verglichen. Der Beitrag schließt mit einer kritischen Würdigung der beiden methodischen Ansätze.
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    OR spectrum 11 (1989), S. 251-251 
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    OR spectrum 11 (1989), S. 250-250 
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    OR spectrum 11 (1989), S. 252-252 
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    OR spectrum 11 (1989), S. 254-254 
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    OR spectrum 11 (1989), S. 253-254 
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    OR spectrum 11 (1989), S. 239-249 
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    Description / Table of Contents: Zusammenfassung VISM (Visual Interactive Simulation Modelling) findet vermehrt Eingang in Ciba-Geigy. Die Anwendung dieses OR-Verfahrens hat erhebliches Nutzenpotential aufgezeigt und zur Einsparung in Millionenhöhe beigetragen. Zur Zeit kann die OR-Gruppe die Nachfrage für weitere Anwendungen nicht vollumfänglich erfüllen. Mit dem Ziel, den Modellierungsproeß zu straffen, wurde ProfiSEE, ein Werkzeug für VISM, entwickelt. ProfiSEE ist ein Werkzeug für „Profis“ und „Profit“, abgestimmt auf die Bedürfnisse der chemischpharmazeutischen Industrie, womit Einblick in Produktionsanlagen vermittelt werden kann. Das Sehen der simulierten Abläufe steht hierbei im Vordergrund. Die Erfahrungen mit einem Prototyp eines Modells zur Untersuchung einer Produktionsanlage eines Farbensynthese- und Standardisierbetriebes trugen wesentlich zur Entwicklung bei. ProfiSEE fördert eine enge Zusammenarbeit der OR-Gruppe und ihren Kunden, da es die Hauptelemente des VISM beinhaltet. Einige Schritte in die Richtung der graphischen Programmierung wurden unternommen. Die Realisierung mittels der Programmierumgebung Smalltalk-80 und eines umfangreichen Informationsverarbeitungs-Systems, The Analyst, benutzt die Vorteile des vielversprechenden objekt-orientierten Ansatzes. Dieser Artikel bewertet die Effizienz und Anwendung von VISM, faßt die Entstehung und Funktionalität von ProfiSEE zusammen, geht auf die eingesetzten Mittel ein, berichtet kurz über aktuelle Anwendungen und skizziert Weiterentwicklungen, die in Bearbeitung sind.
    Notes: Summary The use of Visual Interactive Simulation Modelling (VISM) as an Operations Research (OR) technique is gaining widespread popularity in CIBA-GEIGY. Currently, the demand for these applications, which are contributing millions of SFr. in savings and benefits, exceeds the available manpower in the OR group of CIBA-GEIGY. In an effort to streamline the modelling process the OR group developed a modeller's workbench for VISM called ProfiSEE. ProfiSEE, pronounced prophecy, is a tool forProfessionals andProfit in the chemical-pharmaceutical industry designed for gaining insight throughSEEing a plant or productive unit in operation — hence ProfiSEE. The system grew out of a specific application of VISM in dyestuff production, first presented in 1987 at the annual conferences of the British and German OR societies. ProfiSEE fosters close cooperation between the OR group and its clients through improved communication with VISM as a vehicle. It embodies the core principles of VISM and makes several concrete steps in the direction of graphical programming. ProfiSEE's implementation is at the forefront of software engineering technology. It exploits the advantages of the object-oriented programming environment provided by Smalltalk-802 to the full extent and is embedded in The Analyst, a comprehensive information management tool. This article assesses VISM and its effectiveness; reviews the initial use of VISM and the development of ProfiSEE at CIBA-GEIGY; introduces the implementation tools; summarizes the basic functionality of ProfiSEE; reviews some current applications at CIBA-GEIGY; and, in closing, sketches some developments currently in the pipeline.
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    OR spectrum 11 (1989), S. 231-237 
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    Description / Table of Contents: Summary The aim of this paper is to present the prototype of a computeraided simulation model. The model is able to simulate the behaviour of any hospitalization area. The subject of main interest is how to deal with large numbers of patients. The general model can be used for every hospitalization area simply by adapting parameters and internal organization. The user can choose between different szenarios with patients to fill up the hospital as well. If there is a given szenario and a selected hospitalization area the simulation model is able to show the process and the success of patients' treatment. By analyzing the results of the simulation one can find the bottlenecks, check the efficiency of additional activities and evaluate the limits of the given hospitalization area's capacities and resources. Furthermore the model serves as an educational tool for hospital managers.
    Notes: Zusammenfassung Vorgestellt wird der Prototyp eines computergestützten Simulationsmodells zur Abbildung der Infrastrukturen von Hospitalisationsregionen, bei der die Bewältigung von Ereignissen mit extremen Patientenanfällen im Vordergrund steht. Das allgemein formulierte Modell soll durch die Variation von Parameterwerten den Infrastrukturen (z. B. Führungsstruktur, Transportstruktur und Spitalstruktur) beliebiger Hospitalisationsregionen angepaßt werden können, wobei die Szenarien der Patientenanfälle frei gewählt werden können. Das Simulatiosmodell ist in der Lage, für ein vorgegebenes Szenario den Verlauf und den Erfolg der Patientenversorgung in der abgebildeten Hospitalisationsregion in Abhängigkeit von der frei gewählten Führungsstruktur aufzuzeigen. Die Analyse der Simulationsergebnisse zeigt allfällige Kapazitätsengpässe auf, erlaubt die Auswirkungen von Maßnahmen zur Effizienzsteigerung und zur Beseitigung von Engpässen modellmäßig zu überprüfen und die Grenzen der Versorgungsleistung nach Ausschöpfen aller Kapazitätsreserven abzuschätzen. Das Modell kann im weiteren zu Schulungszwecken verwendet werden.
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    OR spectrum 11 (1989), S. 255-256 
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    OR spectrum 11 (1989), S. 67-82 
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    Description / Table of Contents: Summary This paper reviews corporate investment decisions under risk. Various situations are discussed such as that of a single entrepreneur or that of several owners. In addition, tradable securities may or may not exist. If such trade exists, investment risks can be hedged. But securities can be purchased for investment purposes, too; thus trade in securities does not necessarily favor real corporate investments. Crowding out of such investment projects is possible. The number of owners of a firm does not matter for the allocation of hegdeable risks. A larger number of owners permits a wider distribution of non-hedgeable risks, however. If a manager decides on investments, then his decisions depend also on his income which may be a function of the firm's profits. He may display a strong interest in hedging corporate risks if corporate losses endanger his job. Whether or not he prefers forward to option contracts for hedging purposes, depends on his preferences. If he wants to preserve the chance of high profits, then he prefers options. This paper applies risk theory to investment decisions of firms. It is not intended to derive decision rules which can be easily implemented in the real world; the purpose of the paper is to demonstrate the application of the same concept for decision making in widely different situations.
    Notes: Zusammenfassung Der folgende Überblicksbeitrag untersucht betriebliche Investitionsentscheidungen bei Risiko. Dabei werden verschiedene Situationen zugrundegelegt, so die des Alleinunternehmers, als auch die einer Mehrheit von Gesellschaftern, wobei weiterhin danach unterschieden wird, ob die Gesellschafter auf dem Kapitalmarkt Wertpapiere handeln können oder nicht. Wenn Handel möglich ist, kann dieser zum Hedging von Investitionsrisiken eingesetzt werden. Da Wertpapiere auch zu Investitionszwecken gekauft werden können, begünstigt die Handelbarkeit von Wertpapieren nicht notwendig betriebliche Realinvestitionen. Ein Crowding out solcher Investitionsprojekte ist möglich. Bezüglich der Investitionsrisiken, die auf dem Kapitalmarkt gehedgt werden können, erweist sich die Zahl der Gesellschafter als irrelevant. Sie ist jedoch relevant bezüglich der nichthedgebaren Risiken. Eine Zunahme der Gesellschafter bewirkt eine Verteilung des nicht-hedgebaren Risikos auf mehrere Personen. Trifft ein Manager die Investitionsentscheidungen, dann hängt sein Entscheidungsverhalten auch von seiner Entlohnung ab. An einem betrieblichen Hedging kann er insbesondere dann interessiert sein, wenn Unternehmensverluste seinen Arbeitsplatz gefährden. Ob er Optionen oder Termingeschäfte für Hedgingzwecke vorzieht, hängt davon ab, ob er neben der Vermeidung von Verlusten auch die Chance hoher Gewinne wahren will. Wenn ja, dann zieht er Optionen vor. Der folgende Beitrag wendet das Instrumentarium der Risikotheorie auf die betriebliche Investitionsentscheidung an. Zweck ist dabei nicht die Ableitung von in der Praxis unmittelbar verwendbaren Entscheidungsregeln, sondern die einheitliche Anwendung eines Entscheidungskonzeptes in ganz unterschiedlichen Situationen.
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    OR spectrum 11 (1989), S. 97-100 
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    Description / Table of Contents: Zusammenfassung Es wird gezeigt, daß der Durchsatz eines geschlossenen exponentiellen Warteschlangen-Netzwerks hinsichtlich der Anzahl der Aufträge im System nicht fällt, wenn die Bedienungsrate in jeder Station hinsichtlich der Anzahl der Aufträge in dieser Warteschlange nicht fällt. Die Beweisführung scheint erweiterbar auf eine Vielzahl von Netzwerken ohne Produktionsgleichgewicht.
    Notes: Summary It is shown that the throughput of a closed exponential queueing network is nondecreasing in the number of jobs in the system if the service rate in each station is nondecreasing in the number of jobs in that queue. The line of proof seems to be extendable to a variety of networks without a product form equilibrium.
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    Notes: Summary A promising field of laser utilization is the modification of cell behaviour. Acting on cell biological functions it might be possible to use them to improve medical therapies. This possibility suggests investigation of dosimetry guidelines employing different wavelenghts, power and exposure durations for future potential use of lasers in medicine. In this line of investigation, structural organization and viability of fibroblast has been studied, thus observing that the cell number remains unaltered by low density laser irradiation. Nevertheless, results observed in metabolism variation suggest that, with appropiate irradiation-protocol an efficient modality for enhancement or modulation of cell activity can be found, and thereafter used for therapeutical pourposes.
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    Lasers in medical science 4 (1989), S. 95-103 
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    Notes: Summary Response of rabbit ear blood vessels and defects on the pig skin to Argon and CO2 lasers, (1 to 4 Watts and 0,1 to 0,2 sec pulses), were analysed. Examining lesion depth and its diameter, it was seen, using both lasers, that when power and time exposure increased, lesion depth increased as well, At the same time, when power was increased and the time of irradiation was constant, the diameter of the lesion remained approximately the same. Histologically, by using Argon laser at 1'5 W, there is no evidence of skin lesion but vessel coagulation occurs. On the other hand, more power (3 to 4 W) produces skin destruction. CO2 laser at 1'5 W causes skin destruction while 3 W penetrates deeper, cutting all tissues and producing vessel-wall fragmentation and haemorrhage. In contrast to CO2 laser, which definitly stops blood circulation by cutting the vessels, Argon laser entails many recurrences and vessels re-start circulation; a fact which is not desirable in cutaneous vascular disorders treatment.
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    Lasers in medical science 4 (1989), S. 213-213 
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    Lasers in medical science 4 (1989), S. 235-238 
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    Notes: Abstract Until now there are no national safety regulations for the medical use of lasers in the Netherlands. However, a committee of experts from hospitals, Health Council of the Netherlands, TNO Medical Technology Unit and industry is preparing recommendations. Their work is based on MPE values and special measurements that are performed to assess divergence and intensity distribution of laser beams, as well as optical and thermal properties of materials that are used in the clinical setting. The final intention of the committee is to advise government and hospitals on technical, environmental and administrative measures for the safety of the various medical laser applications.
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    Notes: Abstract Accident prevention regulations, e.g. VBG 93 “Laser Radiation”, are a national particularity in the FRG. The regulations issued by the injuries insurance institutes are binding upon employers and employees. The apparatus and equipment safety law makes the VBG 93 obligatory also for manufacturers and importers. National and international standards are referred to in relevant context in the VBG 93. The VBG 93 is also used by the governmental authorities for the protection of labour. The medical apparatus decree has to be observed also for medical application. Some important aspects of the VBG 93 will be described in detail.
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    Lasers in medical science 4 (1989), S. 329-340 
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    Notes: Abstract In general “Dose” by itself as an amount of energy is not a relevant parameter for the description of penetration by non-ionizing (laser) radiation. But dosimetry should not only include the measurements of relevant parameters and its relatioships to tissue effects but also include all possibilities of measurements and relationships which help to control the biological result on tissue by irraditation with non-ionizing laser radiation.
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    Lasers in medical science 4 (1989), S. 361-365 
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    Notes: Abstract In this paper the Author presents the guidelines of laser therapy in the Lisbon Institute of Ophthalmology, with spetial referance to the laser parameters, the ocular pathology imposing laser therapy and the necessary conditions for safety of the patient and of the doctor, operating with laser.
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    Lasers in medical science 4 (1989), S. 41-61 
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    Notes: Abstract A review is presented of Raman spectroscopic applications in the study of laser-tissue interactions. The basic definitions of Raman spectroscopy are given with emphasis to those concepts and techniques which are relevant to biomedical material characterization. Representative problems from current literature will be discussed, like atherosclerosis of human vessels, eye lens aging, formation and diagnosis of cataracts.
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    Notes: Abstract Three different lasers were compared under the same conditions for their effectiveness at producing photodynamic damage to normal colon following sensitization with aluminium sulphonated phthalocyanine (AlSPc). One laser was an argon ion pumped continuous wave (CW) dye laser and the other two were pulsed at 10 kHz (copper vapour laser pumped dye laser, and 5 Hz (flashlamp pumped dye laser). The CW and 10 kHz laser were equally effective at producing damage. The 5 Hz laser failed to produce a photodynamic effect, although occasionally caused a photomechanical effect when the laser fibre was placed touching the colonic mucosa. Quantitative analysis suggests that the high energy pulses of the flashlamp pumped dye laser saturate AlSPc, so very little of the available energy can be used to produce a photodynamic effect, in contrast to the two other lasers which do not produce saturation conditions.
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    ISSN: 1435-604X
    Keywords: YAG Laser/Electrodiathermy ; Pulmonary tissue
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    Notes: Abstract An anatomo-pathological study was undertaken to evaluate the early effects of high and low powered non-contact mode of YAG laser on pulmonary tissue and to compare these effects with those resulting from electro-diathermy. In 40 patients with bronchial carcinoma, thoracotomy was carried out using conventional surgical methods, the part of the lung destined to be excised was then exposed to: Non-contact YAG laser of high or low power (Group A, n=15); cutting/ or coagulation electro-diathermy (Group B,n=15); and mixed (blend) cutting and coagulation electro-diathermy (Group C,n=10). The results indicated that high power non-contact YAG laser is capable of incising the pulmonary parenchyma without bleeding or air leak, only the larger and sub-segmental vessels and bronchial branches needed suturing. This was not the case for electro-diathermy, either in its cutting or blend form. The low power laser was capable of sealing off the superficial bleeding vessels and contracting the alveolar sacs, thus preventing bleeding and air leak. Only the superficial bleeding could be stopped by coagulation diathermy which had no effect in preventing air leak from the parenchyma. Microscopically, apart from evaporation, laser produced charring and coagulative necrosis in the remaining exposed tissue. No evaporation of tissue occurred with electro-diathermy (either in its cutting, blend or coagulation mode). Only a very limited charring and coagulative necrosis was present in the remaining tissues exposed to coagulation electro-diathermy.
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    Lasers in medical science 4 (1989), S. 13-16 
    ISSN: 1435-604X
    Keywords: Nd-YAG laser ; Open lung surgery
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    Topics: Medicine , Physics , Technology
    Notes: Abstract We report on nineteen patients who successfully underwent open lung performance with a Nd-YAG laser in the period December 1987 to August 1988. Reasons for laser operations were lung metastases (twelve cases), lung fibrosis (five patients), one lung cyst and one tuberculoma. We used the Nd-YAG laser in non-contact mode, with focus hand-piece spot size of 1.5 mm, a continual 1064 nm wavelength and a power output 90 W. In these nineteen cases we performed 35 laser photoablations of lung tissue. All patients healed without any serious complications. The major advantage of Nd-YAG laser beam in open lung surgery is in the rapid sealing effect of small airways and of blood vessels up to 3 mm. The Nd-YAG laser seems to be very suitable for operations in lung periphery.
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    Lasers in medical science 4 (1989), S. 65-65 
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    Lasers in medical science 4 (1989), S. 71-72 
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  • 67
    ISSN: 1435-604X
    Keywords: Cholesteatoma ; Haematoporphyrin ; Photo-dynamic therapy
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    Topics: Medicine , Physics , Technology
    Notes: Abstract In a previous project on haematoporphyrin (HP) uptake by experimentally induced cholesteatoma of the rabbit, it was shown that HP concentration was remarkably high in the cholesteatoma, with a peak at three hours after intravenous administration of the drug. On the basis of these results an attempt was made to destroy the matrix of cholesteatoma by means of photodynamic therapy. Cholesteatomas were induced bilaterally in the ears of eight rabbits which were divided into two groups, according to the interval between HP administration (5 mg/kg body weight) and irradiation. The irradiation was carried out with light at 600–680 nm, filtered from the emission a quartz halogen lamp (dose rate 300 mW cm−2; total dose 120 J cm−2). The first group was submitted to photodynamic therapy after three hours and the second after twelve hours. In both groups half the rabbits were sacrificed at 24 h and half at 48 h post-irradiation. Histological studies showed significant vascular lesions, necrosis of the wall of the cholesteatoma, interstitial extravasation of blood, and oedema in a high percentage of the animals. The lesions were much greater in animals sacrificed at 48 h after photodynamic therapy.
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    Lasers in medical science 4 (1989), S. 137-138 
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    Lasers in medical science 4 (1989), S. 151-154 
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    Topics: Medicine , Physics , Technology
    Notes: Abstract The treatments of 250 patients with the CO2 laser is described. The procedures were performed under local anaesthesia with minimal instrumentation apart from the laser. Operations were rapid and relatively bloodless, and excellent cosmetic and functional results were obtained. In the post-operative period there was minimal oedema and no significant bleeding. Post-operative pain was also minimal allowing patients to resume their normal diet on the first post-operative day and to return to work. The experience gained with this first group of patients suggests that ideal cases for treatment by this modality include leukoplakia, haemangiomas, epulis and prosthesis fibromas. The CO2 laser is now being used to a lesser extent on in-patients and on those with malignant lesions.
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  • 70
    ISSN: 1435-604X
    Keywords: Autofluorescence ; Laser-induced fluorescence ; Laser-induced breakdown spectroscopy ; Atherosclerosis ; Tissue diagnostics
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    Notes: Abstract We have investigated laser-induced fluorescence frompost mortem human arteries in order to find spectroscopic properties allowing discrimination between normal and atherosclerotic vessel wall. A pulsed nitrogen laser emitting light at a wavelength of 337.1 nm was used as an excitation source. The fluorescence spectrum from 370 to 700 nm was captured and analysed by an optical multichannel analyser. Dimensionless contrast functions were formed by using characteristic spectral features at 390, 415, 480, 580 and 600 nm. All samples were investigated in scans across a region where normal as well as diseased vessel wall appeared. The types of plaque were histopathologically divided into four groups, of which three could be singled out using one or more of our spectroscopic criteria. We also investigated the different layers of the normal and diseased vessel wall in order to determine the various contributions to the fluorescence signal. Furthermore, plasma emission spectra were recorded while ablating the normal as well as the diseased vessel wall with an excimer laser, emitting radiation at 308 nm, thus detecting the change in spectral characteristics during the ablation process down into deeper layers.
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    Lasers in medical science 4 (1989), S. 203-204 
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    Lasers in medical science 4 (1989), S. 183-186 
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Gastrointestinal tumour ; Advanced lesions
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    Topics: Medicine , Physics , Technology
    Notes: Abstract In the study, 120 patients with advanced gastrointestinal tumours were treated by PDT; 5 mg/kg of HpD was intravenously given 48–72 h prior to PDT. The light source was an argon dye laser with an output beam of 630 nm. The irradiation time varied from 15–25 min with a power of 100–350 mW cm−2. The entire tumour was irradiated with a light dose of 100–250 J cm−2. Of the 120 patients, 20 had cancer of esophagus, 72 had cancer of the gastric cardia, 18 had cancer of the stomach and 10 had cancer of the rectum. Eighty-eight patients (73.3%) had a response to PDT. Twelve patients with CR were followed up for one to five years, two patients died during the two years after PDT.
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  • 73
    ISSN: 1435-604X
    Keywords: Brain tumour ; Rat ; Detection ; Fluorescence ; Laser ; Haematoporphyrin derivative
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    Notes: Abstract Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with normal brain tissue, and at the same time the characteristic red-drug signal increased. The contrast between tumour and normal tissue was strongly enhanced by forming the ratio between the two signals. Implications for possible improvement of tumour delineation in brain tumour surgery are discussed.
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    Lasers in medical science 4 (1989), S. 285-287 
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  • 75
    ISSN: 1435-604X
    Keywords: Low-level laser irradiation ; Peripheral nerve injury ; Single effect of 632.8, 660, 830, 880 and 950 nm wavelengths
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    Topics: Medicine , Physics , Technology
    Notes: Abstract Twenty rats underwent a crush injury to their sciatic nerve, followed immediately by a single low-power coherent or non-coherent irradiation administered transcutaneously on the projection of an injured peripheral nerve. Five wavelengths were tested: 632.8, 660, 830, 880 and 950 nm. The electrical activities of the crushed nerve, immediately after irradiation and on the following first, third and seventh day post-crush, were compared to the precrush activity. The results indicate that energy at the wavelength of 632.8 nm (CW He-Ne laser), delivered transcutaneously (10 J cm−2 at each point) along the projections of the nerve, prevents the drop in the functional nerve activity as measured by the combined action potential (AP) after crush injury. Other wavelengths were either less effective (660 nm) or totally ineffective under the same conditions. The beneficial effects were temporary and lasted only one day after injury and the single irradiation session.
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    Lasers in medical science 4 (1989), S. 199-202 
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    Lasers in medical science 4 (1989), S. 211-220 
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  • 78
    ISSN: 1435-604X
    Keywords: Argon laser ; Port-wine stains ; Transcutaneous microscopy
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    Topics: Medicine , Physics , Technology
    Notes: Abstract Sixty-two consecutive patients presenting with facial port-wine stains were examined by transcutaneous microscopy prior to argon laser treatment. The capillary morphology was classified and the late outcome was independently examined and scored. It was found that capillary appearances do have some value in predicting a favourable response and in predicting scarring.
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    ISSN: 1435-604X
    Keywords: Argon laser, Photodynamic therapy ; Cancer
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    Topics: Medicine , Physics , Technology
    Notes: Abstract The effect of continuous-wave argon laser radiation on the growth of solid Ehrlich carcinoma was studied in mice. To enhance the tumour sensitivity to laser radiation, compounds of a porphyrin series were given to animals prior to the laser treatment. Out of 14 substances tested, tetraphenylporphyn-sulphonate and its palladium complex had the most pronounced photosensitizing activity comparable with that of haematoporphyrin derivative (HPD). Metallic complexes of tetraphenylporphyn and protoporphyrin were less active. It is concluded that porphyrins are promising sensitizers for photodynamic therapy (PDT).
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    Lasers in medical science 4 (1989), S. 289-290 
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  • 81
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Haematoporphyrin ; Argon dye laser ; Early stage esophageal cancer ; Head and neck cancer ; Squamous cell carcinoma ; Adenocarcinoma
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    Topics: Medicine , Physics , Technology
    Notes: Abstract This is the report of a pilot study in which the technique of photodynamic therapy (PDT)—in which malignant tissues are destroyed by light after being previously photosensitized by haematoporphyrin or its derivative—was performed using a high power argon-dye laser system which operated at 630±5 nm and optical fibres with either a microlens or a diffusing tip. A total of thirty-seven patients were utilized for this study, including twenty-five patients affected by esophageal carcinoma, five by recurrences of head and neck cancer, four by gastric cancer and three by lung cancer. Among the sixteen cases with superficial or localized cancer of the esophagus, complete and partial responses were observed in seven and six patients, respectively. In advanced and recurring cancers less satisfactory results were obtained. Thus, PDT seems to be useful in cases of small superficial cancers, either primary or recurrent after previous treatments.
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    Empirical economics 14 (1989), S. 1-19 
    ISSN: 1435-8921
    Keywords: Input-output-model ; “make”- and “use”-matrices ; disaggregated econometric model
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    Topics: Economics
    Notes: Abstract The author presents a neoclassical input-output-model for the Federal Republic of Germany, which is based on “make”- and “use”-tables instead of input-output-tables. The advantage of this approach is, that the model is able to discriminate volumes and prices for industries and commodities. The analytical frame-work gives economic hypotheses to explain the coefficients of “make”- and “use”-matrices. So a blended functional/institutional input-output-model can be constructed, which offers the opportunity to use different schemes for the disaggregation of final demand and primary inputs. The article describes the theoretical model and the numerical specification of an econometric model, which is based on it. At the end the results of an ex-post-projection with this econometric model are discussed.
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    Empirical economics 14 (1989), S. 21-42 
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    Topics: Economics
    Notes: Abstract The paper analyzes the commodity structure of exports and imports of nine industrialized countries, using a dynamic version of the Linear Expenditure System. The hypothesis implied by this approach is that the structure of commodity trade can be explained by a combination of habit persistence and constant marginal expenditure shares. Application of the model to the trade composition of nine countries shows that there are considerable differences in the strength of habit persistence across countries and across commodity groups as well as between exports and imports. These are crucial for the explanation of the associated expenditure and price elasticities.
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    Empirical economics 14 (1989), S. 77-92 
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    Topics: Economics
    Notes: Summary It is remarkably easy to test for structural change, of the type that the classicFor “Chow” test is designed to detect, in a manner that is robust to heteroskedasticity of possibly unknown form. This paper first discusses how to test for structural change in nonlinear regression models by using a variant of the Gauss-Newton regression. It then shows how to make these tests robust to heteroskedasticity of unknown form, and discusses several related procedures for doing so. Finally, it presents the results of a number of Monte Carlo experiments designed to see how well the new tests perform in finite samples.
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    Empirical economics 14 (1989), S. 105-112 
    ISSN: 1435-8921
    Keywords: Brownian Motion ; Brownian Bridge ; Invariance ; Locally Best Invariant Test ; Mixing ; Random Walk ; Weak Convergence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Summary This article is concerned with Locally Best Invariant tests for coefficient stability in a univariate random walk coefficient regression model. In particular, we explore the effects that different assumptions about the initial value of the random walk process have on the form and asymptotic distribution of the resulting test statistics. When this initial value is allowed to be random, it is shown that the test statistics are either exactly the same, or possess the same asymptotic distributions, as when the initial value is fixed.
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    Empirical economics 14 (1989), S. 139-150 
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    Topics: Economics
    Notes: Abstract This note argues that structural stability is an important condition for tests of Grangercausality. Despite this fact the standard causality tests are sometimes applied to data for which structural stability cannot be assumed a priori. Therefore the stability of GNP/M1 systems of the U.S., Canada, and West Germany in the aftermath of the 1973/74 oil crisis is analyzed using formal statistical tests. Prediction tests are particularly useful for that purpose. The stability of the model for Canadian data is rejected whereas stability is not rejected for the U.S. and West Germany.
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    Empirical economics 14 (1989), S. 151-165 
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    Topics: Economics
    Notes: Summary The paper shows that the sequential approach to testing econometric models, particularly testing for structural change, is both feasible and potentially very useful. In fact, this paper makes clear the possibility of using the sequential approach as suggested by Dhrymes et al. (1972) and shows that the statistical dependence between successive tests can be overcome in some cases.
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    Empirical economics 14 (1989), S. 215-227 
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  • 89
    ISSN: 1435-8921
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    Topics: Economics
    Notes: Summary The paper formulates and estimates for India for the period 1950–1980 an aggregate production function wherein the supply of real money balances in the economy appears as a limitational factor of production. The rationale for the formulation is argued from the importance of working capital funds in organising production, and how the supply of money, or the lack thereof, may constrain its availability in a financially underdeveloped economy characterized by imperfect capital markets.
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    Empirical economics 14 (1989), S. 257-271 
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    Topics: Economics
    Notes: Abstract The necessary and sufficient conditions for determining Granger causality with a bivariate ARMA model have been presented by Granger (1969), Haugh and Pierce (1977) and Eberts and Steece (1984). However the literature fails to address the question as to which classical test criterion likelihood ratio, Lagrange multiplier, Rao efficient scoring or Wald should be employed. This study addresses this question via a simulation study.
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    Empirical economics 14 (1989), S. 291-305 
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    Topics: Economics
    Notes: Abstract A structural model of demand and supply of money for the U.S. economy is estimated by the relatively new Simultaneous Transfer Function Method. This approach is motivated by (1) a need to impose valid identifying restrictions on the model and (ii) to facilitate a systematic specification search process. The endogeneity of monetary stock is effectively dealt with at two levels. Policy-wise endogeneity is handled by defining the money supply variable as a ratio of observed and exogenous monetary stock (based on reserves supplied by the Fed). Statistical endogeneity is captured in a Simultaneous Equations System. Empirical results show that commercial banks are able to alter observed monetary stock behavior when the profitability of creating new loans (deposits) increases. This accommodation is, expectedly, fairly small and instantaneous.
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    Empirical economics 14 (1989), S. 123-137 
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    Topics: Economics
    Notes: Summary Robust Bayesian analyses in a conjugate normal framework have been developed by Learner (1978) and Polasek and Pötzelberger (1987). Fixing the prior mean and varying the prior covariance Matrix yields a so-called feasible ellipsoid for the posterior mean and robust HPD regions, also called HiFi-regions. This paper considers the application of this approach to gain robust Bayesian inference in case of a parameter change in regression models.
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    Empirical economics 14 (1989), S. 167-192 
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    Empirical economics 14 (1989), S. 193-213 
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    Topics: Economics
    Notes: Summary This paper describes a theoretical and empirical study of the Japanese macroeconomy that focuses on the role of predetermined nominal wages in the relation between monetary policy and aggregate output. The main features of the model are that nominal wage rates set at Shunto are equal to rational expectations of the nominal wage rates that would be consistent with target levels of real output and that firms determine employment and output by equating marginal productivities to real wage rates. The essential implication of the model is that the current deviation of aggregate output from its target level depends only on innovations in inflation and productivity since the last Shunto. The equation derived to implement the model empirically relates current aggregate output growth in a precise way to Past values of output growth and inflation since the last Shunto and includes an explicit specification of a white noise error term. The results of econometric analysis of this restricted model equation are consistent with the hypothesis that nominal wages, predetermined according to Shunto with rational expectations, are important for the determination of real aggregates.
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    Empirical economics 14 (1989), S. 241-256 
    ISSN: 1435-8921
    Keywords: Testing Calendar Effects ; Structural Models ; Generalized Regression Model ; Kalman Filter ; Minimum Mean Square Estimator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Calendar effects are analysed in the class of structural time series models one of the two main model based approaches in time series decomposition. While Bell and Hillmer (1983) modeled calendar variation in the ARIMA model based approach, we represent structural models in the generalized regression form which allows to apply classical estimation and test procedures. It turns out that the expected high computaional complexity 0(T 3) in the generalized regression model can be reduced to 0(T). As all parameters are estimated by maximizing the likelihood the Likelihood Ratio statistics can be used to test effects of the calendar composition.
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    Empirical economics 14 (1989), S. 273-289 
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    Topics: Economics
    Notes: Abstract This paper makes use of the fact that the stock of medical manpower in Canada is institutionally and exogenously determined in order to develop a model predicting physician average net income. An econometric evaluation of this model on a sample involving Canada's ten provinces during 1968–1982 suggests that a one per cent increase in physician fees increases physician average net income by 0.70 per cent, and a one per cent increase in the physician to population ratio reduces average net income by 0.62 per cent. In both cases, the elasticities are less than unity because the supply function for an individual physician is backward bending — on average, a Canadian physician reduces his hours worked by an amount between 0.17 and 0.50 per cent (95 per cent confidence interval) if his real wage rate is increased by one per cent.
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    Empirical economics 14 (1989), S. 307-328 
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    Topics: Economics
    Notes: Summary A four-variable, a five-variable and a six-variable vector autoregression (VAR) is used in the study to test empirically the linkages among changes in money, outstanding public bonds, interest rates, output, real asset prices, and real investment expenditures in West Germany. After estimating Sims-type and Hsiao-type vector autoregressions the VAR models are the converted to their moving-average representations and the innovation accounting technique is used to examine the impact of changes in asset prices and output on investment behaviour.
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    Empirical economics 14 (1989), S. 329-342 
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    Topics: Economics
    Notes: Abstract The wellknown Wallace-Hussain estimator is applied in pooled models with random individual effects, and the magnitude of the bias caused by the estimator is estimated by bootstrap methods. Furthermore, the significance of the bias is tested using an asymptotic test based on the bootstrap results.
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    Polymer bulletin 21 (1989), S. 221-228 
    ISSN: 1436-2449
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    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Proton NMR spectra and spin-lattice relaxation time (T1) for polyaniline doped with HCl were measured at 90MHz over a temperature range of 110–430K. A narrow line with a width of about 1–2KHz superimposed on broad NMR peak was observed above 210K, and it was tentatively assigned to the protons in dopant and absorbed water. The analysis of linewidths and second moments for the broad lines reveal two distinct relaxation processes with activation energies of 1.9 and 7.8Kcal./mole,respectively. The former may be associated with the motion of the dopant and water absorbed and the latter with the rotation of benzoid ring about C-N bond axis. The second moment data suggest that the twist angle between the adjacent rings decreases with rising the doping ratio. Proton NMR relaxation rate was fitted with a theoretical equation containing the contributions from nuclear dipolar interaction and from electron-proton interaction, Rd and Rp, respectively.Rd is negligible below room temperature and Rp has little change above 100K. The total relaxation rate is dominated by Rp near room temperature.
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    Polymer bulletin 21 (1989), S. 259-263 
    ISSN: 1436-2449
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    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Acrylonitrile was polymerized by an insertion process on being added to solutions containing the adduct of the reaction of tetrakis(dimethylamino) titanium (T4) and azobisisobutyronitrile (AIBN). The obtained azo-linked polyacrylonitrile has appropriate initiating functionality for a subsequent vinyl polymerization.
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